| 1. |
- Alimohammadi, Mohammad, et al.
(författare)
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Pulmonary Autoimmunity as a Feature of Autoimmune Polyendocrine Syndrome Type 1 and Identification of KCNRG as a Bronchial Autoantigen
- 2009
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:11, s. 4396-4401
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Tidskriftsartikel (refereegranskat)abstract
- Patients with autoimmune polyendocrine syndrome type 1 (APS-1) suffer from multiple organ-specific autoimmunity with autoantibodies against target tissue-specific autoantigens. Endocrine and nonendocrine organs such as skin, hair follicles, and liver are targeted by the immune system. Despite sporadic observations of pulmonary symptoms among APS-1 patients, an autoimmune mechanism for pulmonary involvement has not been elucidated. We report here on a subset of APS-1 patients with respiratory symptoms. Eight patients with pulmonary involvement were identified. Severe airway obstruction was found in 4 patients, leading to death in 2. Immunoscreening of a cDNA library using serum samples from a patient with APS-1 and obstructive respiratory symptoms identified a putative potassium channel regulator (KCNRG) as a pulmonary autoantigen. Reactivity to recombinant KCNRG was assessed in 110 APS-1 patients by using immunoprecipitation. Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms, but in only 1 of 102 APS-1 patients without respiratory symptoms. Expression of KCNRG messenger RNA and protein was found to be predominantly restricted to the epithelial cells of terminal bronchioles. Autoantibodies to KCNRG, a protein mainly expressed in bronchial epithelium, are strongly associated with pulmonary involvement in APS-1. These findings may facilitate the recognition, diagnosis, characterization, and understanding of the pulmonary manifestations of APS-1.
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| 2. |
- Bergman, Jonas, et al.
(författare)
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When the River Began—The Formation of River Motala Ström and Human Presence in the Early Holocene, Sweden
- 2020
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Ingår i: Quaternary. - : MDPI AG. - 2571-550X. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- In conjunction with the extensive archaeological projects conducted at the current outlet of Sweden’s second largest lake, Lake Vättern, macrofossil, pollen and diatom records have been studied from 14C-dated lake and river sediments from River Motala Ström in Motala and Lake Boren. These investigations have revealed sedimentary evidence of the Yoldia Sea regression, the Ancient Lake Vättern transgression, and the following stepwise river formation process. Around 9000 cal BC, two small kettlehole basins at Strandvägen and Kanaljorden became isolated from the Baltic basin. As the ice sheet retreated further north, the isostatic uplift isolated the Vättern basin from the Baltic basin. Due to the uneven isostatic uplift, the basin tilted toward the south, and the Ancient Lake Vättern transgression started in Motala. The threshold in Motala at 92.5 m a.s.l. was reached around 7200 cal BC, and River Motala Ström was formed. 14C-dated diatom records from Lake Boren, and shoreline deposits in Motala, confirm this event. The water level in Lake Vättern initially fell around 1.5 m, and around 5800 cal BC, a second erosional event cut down the threshold to modern day level. At this time, the Late Mesolithic settlements in Motala were established and expanded.
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| 3. |
- Eriksson, Gunilla, et al.
(författare)
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Diet and mobility among Mesolithic hunter-gatherers in Motala (Sweden) - The isotope perspective
- 2018
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 2352-409X .- 2352-4103. ; 17, s. 904-918
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Tidskriftsartikel (refereegranskat)abstract
- Recent excavations at the sites of Strandvägen and Kanaljorden in Motala, Eastern Central Sweden, have unearthed complex and varied funerary remains from the Mesolithic. The two sites are situated on opposite banks of the river Motala Ström. While geographically close and roughly covering the same time span (c. 8000–7000 cal. BP), the funerary remains reveal differences and similarities in the treatment of the dead between the two localities. While at Strandvägen human bones were mostly found either scattered along the river bed or in inhumation graves, Kanaljorden contains wetland depositions of disarticulated skulls. We have conducted multi-isotope analyses of δ13C, δ15N, δ34S and 87Sr/86Sr of human and animal remains with the aim of reconstructing the dietary patterns, geographic provenance and mobility of the interred. A series of faunal reference samples and, in the case of 87Sr/86Sr, soil samples have been analysed in order to establish relevant isotopic baselines. The results show a protein intake dominated by aquatic resources, probably consisting of both freshwater and marine fish in varied proportions. The strontium isotope data indicate an interesting distinction between the individuals buried on either side of the river Motala Ström. Five out of six sampled individuals from Strandvägen have isotope ratios consistent with a local provenance, whereas ratios from seven out of eight Kanaljorden individuals indicate a non-local origin. The δ34S analysis proved problematic as a majority of the samples appear to be affected by diagenesis. This is probably the result of contamination by exogenous sulphur from surrounding fluvial and lacustrine sediments, as has previously been reported from other waterlogged sites.
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| 4. |
- Abdallah, J., et al.
(författare)
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A measurement of the tau hadronic branching ratios
- 2006
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 46:1, s. 1-26
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Tidskriftsartikel (refereegranskat)abstract
- The exclusive and semi-exclusive branching ratios of the tau lepton hadronic decay modes (h(-)upsilon(tau), h(-)pi(0)upsilon(tau), h(-)pi(0)pi(0)upsilon(tau), h(-) >= 2 pi(0)nu(tau), 2h(-)h(+)upsilon(tau), 2h(-)h(+)>= 2 pi(0)upsilon(tau), 3h(-)2h(+)upsilon(tau) and 3h(-)2h(+) >= 1 pi(0)upsilon(tau)) were measured with data from the DELPHI detector at LEP.
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| 5. |
- Abdallah, J., et al.
(författare)
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A study of the b-quark fragmentation function with the DELPHI detector at LEP I and an averaged distribution obtained at the Z Pole
- 2011
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:2, s. 1557-
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Tidskriftsartikel (refereegranskat)abstract
- The nature of b-quark jet hadronisation has been investigated using data taken at the Z peak by the DELPHI detector at LEP. Two complementary methods are used to reconstruct the energy of weakly decaying b-hadrons, E-B(weak). The average value of x(B)(weak) = E-B(weak)/E-beam is measured to be 0.699 +/- 0.011. The resulting x(B)(weak) distribution is then analysed in the framework of two choices for the perturbative contribution (parton shower and Next to Leading Log QCD calculation) in order to extract measurements of the non-perturbative contribution to be used in studies of b-hadron production in other experimental environments than LEP. In the parton shower framework, data favour the Lund model ansatz and corresponding values of its parameters have been determined within PYTHIA 6.156 from DELPHI data: a = 1.84(-0.21)(+0.23) and b = 0.642(-0.063)(+0.073) GeV-2, with a correlation factor rho = 92.2%. Combining the data on the b-quark fragmentation distributions with those obtained at the Z peak by ALEPH, OPAL and SLD, the average value of x(B)(weak) is found to be 0.7092 +/- 0.0025 and the non-perturbative fragmentation component is extracted. Using the combined distribution, a better determination of the Lund parameters is also obtained: a = 1.48(-0.10)(+0.11) and b = 0.509(-0.023)(+0.024) GeV-2, with a correlation factor rho = 92.6%.
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| 6. |
- Abdallah, J., et al.
(författare)
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Investigation of colour reconnection in WW events with the DELPHI detector at LEP-2
- 2007
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 51:2, s. 249-269
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Tidskriftsartikel (refereegranskat)abstract
- In the reaction e(+)e(-) -> WW -> (q(1) (q) over bar (2))(q(3)(q) over bar (4)) the usual hadronization models treat the colour singlets q(1)(q) over bar (2) and q(3)(q) over bar (4) coming from two W bosons independently. However, since the. nal state partons may coexist in space and time, cross-talk between the two evolving hadronic systems may be possible during fragmentation through soft gluon exchange. This e. ect is known as colour reconnection. In this article the results of the investigation of colour reconnection e. ects in fully hadronic decays of W pairs in DELPHI at LEP are presented. Two complementary analyses were performed, studying the particle. ow between jets and W mass estimators, with negligible correlation between them, and the results were combined and compared to models. In the framework of the SK-I model, the value for its. parameter most compatible with the data was found to be: (SK)-S-kappa-I = 2.2(-1.3) (+2.5) corresponding to the probability of reconnection P-reco to be in the range 0.31 < P-reco < 0.68 at 68% confidence level with its best value at 0.52.
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| 7. |
- Abdallah, J., et al.
(författare)
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Masses, lifetimes and production rates of Xi(-) and Xi(+) at LEP 1
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 639:3-4, s. 179-191
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the Xi(-) and (Xi) over bar (+) masses, mass differences, lifetimes and lifetime differences are presented. The (Xi) over bar (+) sample used is much larger than those used previously for such measurements. In addition, the S production rates in Z -> b (b) over bar and Z -> q (q) over bar events are compared and the position xi* of the maximum of the distribution in Z -> q (q) over bar events is measured.
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| 8. |
- Abdallah, J., et al.
(författare)
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Measurement of the electron structure function F-2(e) at LEP energies
- 2014
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 737, s. 39-47
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Tidskriftsartikel (refereegranskat)abstract
- The hadronic part of the electron structure function F-2(e) has been measured for the first time, using e(+)e(-) data collected by the DELPHI experiment at LEP, at centre-of-mass energies of root s = 91.2-209.5 GeV. The data analysis is simpler than that of the measurement of the photon structure function. The electron structure function F-2(e) data are compared to predictions of phenomenological models based on the photon structure function. It is shown that the contribution of large target photon virtualities is significant. The data presented can serve as a cross-check of the photon structure function F-2(gamma) analyses and help in refining existing parameterisations.
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| 9. |
- Abdallah, J., et al.
(författare)
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Search for a fourth generation b '-quark at LEP-II at root s=196-209GeV
- 2007
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 50:3, s. 507-518
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Tidskriftsartikel (refereegranskat)abstract
- A search for the pair production of fourth generation b'-quarks was performed using data taken by the DELPHI detector at LEP-II. The analysed data were collected at centre-of-mass energies ranging from 196 to 209 GeV, corresponding to an integrated luminosity of 420 pb(-1). No evidence for a signal was found. Upper limits on BR(b'-> bZ) and BR(b'-> bZ) were obtained for b' masses ranging from 96 to 103 GeV/c(2) stop. These limits, together with the theoretical branching ratios predicted by a sequential four generations model, were used to constrain the value of R-CKM=vertical bar V-cb(') /V-tb'V-tb vertical bar there V-cb', V-tb' and V-tb are elements of the extended CKM matrix.
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| 10. |
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| 11. |
- Abdallah, J., et al.
(författare)
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Search for excited leptons in e(+)e(-) collisions at root s=189-209 GeV
- 2006
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 46:2, s. 277-293
-
Tidskriftsartikel (refereegranskat)abstract
- A search for excited lepton production in e(+)e(-) collisions was performed using the data collected by the DELPHI detector at LEP at centre-of-mass energies ranging from 189 GeV to 209 GeV, corresponding to an integrated luminosity of approximately 600 pb(-1). No evidence for excited lepton production was found. In searches for pair-produced excited leptons, lower mass limits were established in the range 94-103 GeV/c(2), depending on the channel and model assumptions. In searches for singly-produced excited leptons, upper limits on the parameter f/Lambda were established as a function of the mass.
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| 12. |
- Abdallah, J., et al.
(författare)
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Search for pentaquarks in the hadronic decays of the Z boson with the DELPHI detector at LEP
- 2007
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 653:2-4, s. 151-160
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Tidskriftsartikel (refereegranskat)abstract
- The quark model does not exclude states composed of more than three quarks, like pentaquark systems. Controversial evidence for such states has been published in the last years, in particular: for a strange pentaquark Theta(1540)(+); for a double-strange state, the Xi(1862)(--), subsequently called Phi(1860)--; and for a charmed state, the Theta(c)(3100)(0). If confirmed, a full pentaquark family might exist; such pentaquark states could be produced in e(+)e(-) annihilations near the Z energy. In this Letter a search for pentaquarks is described using the DELPHI detector at LEP, characterized by powerful particle identification sub-systems crucial in the separation of the signal from the background for these states. At 95% CL, upper limits are set on the production rates N of such particles and their charge-conjugate state per Z decay: N-Theta+ x Br(Theta(+) -> pK(S)(0)) < 5.1 x 10(-4), N Theta++ < 1.6 x 10(-3), N Phi(1860)-- x Br((P(1860)-- -> Xi(-)pi(-)) < 2.9 x 10(-4), N-Theta c(3100)0 x Br(Theta(c)(3100)(0) -> D*(+)p) < 8.8 x 10(-4).
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| 13. |
- Abdallah, J., et al.
(författare)
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Search for single top quark production via contact interactions at LEP2
- 2011
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:2, s. 1555-
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Tidskriftsartikel (refereegranskat)abstract
- Single top quark production via four-fermion contact interactions associated to flavour-changing neutral currents was searched for in data taken by the DELPHI detector at LEP2. The data were accumulated at centre-of-mass energies ranging from 189 to 209 GeV, with an integrated luminosity of 598.1 pb(-1). No evidence for a signal was found. Limits on the energy scale Lambda, were set for scalar-, vector- and tensor-like coupling scenarios.
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| 14. |
- Abdallah, J., et al.
(författare)
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Study of leading hadrons in gluon and quark fragmentation
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 643:3-4, s. 147-157
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Tidskriftsartikel (refereegranskat)abstract
- The study of quark jets in e(+)e(-) reactions at LEP has demonstrated that the hadronisation process is reproduced well by the Lund string model. However. our understanding of gluon fragmentation is less complete. In this study enriched quark and gluon jet samples of different purities are selected in three-jet events from hadronic decays of the Z collected by the DELPHI experiment in the LEP runs during 1994 and 1995. The leading systems of the two kinds of jets are defined by requiring a rapidity gap and their sum of charges is studied. An excess of leading systems with total charge zero is found for gluon jets in all cases, when compared to Monte Carlo simulations with JETSET (with and without Bose-Einstein correlations included) and ARIADNE. The corresponding leading systems of quark jets do not exhibit such an excess. The influence of the gap size and of the gluon purity on the effect is studied and a concentration of the excess of neutral leading systems at low invariant masses (less than or similar to 2 GeV/c(2)) is observed, indicating that gluon jets might have an additional hitherto undetected fragmentation mode via a two-gluon system. This could be an indication of a possible production of gluonic states as predicted by QCD.
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| 15. |
- Abdallah, J., et al.
(författare)
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Study of triple-gauge-boson couplings ZZZ, ZZ gamma and Z gamma gamma at LEP
- 2007
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 51:3, s. 525-542
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Tidskriftsartikel (refereegranskat)abstract
- Neutral triple-gauge-boson couplings ZZZ, ZZγ and Zγγ have been studied with the DELPHI detector using data at energies between 183 and 208 GeV. Limits are derived on these couplings from an analysis of the reactions e+e-→Zγ, using data from the final states γff̄, with f=q or ν, from e+e-→ZZ, using data from the four-fermion final states qq̄qq̄, qq̄μ+μ-, qq̄e+e-, qq̄νν̄, μ+μ-νν̄ and e+e-νν̄, and from e+e-→Zγ*, in which the final state γ is off mass-shell, using data from the four-fermion final states qq̄e+e- and qq̄μ+μ-. No evidence for the presence of such couplings is observed, in agreement with the predictions of the Standard Model.
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| 16. |
- Ahlgren, Kerstin M., et al.
(författare)
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Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model
- 2011
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 41:1, s. 235-245
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Tidskriftsartikel (refereegranskat)abstract
- Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal failure are hallmarks of the disease. The critical mechanisms causing chronic mucocutaneous candidiasis in APS-1 patients have not been identified although autoantibodies to cytokines are implicated in the pathogenesis. To investigate whether the Th reactivity to Candida albicans (C. albicans) and other stimuli was altered, we isolated PBMC from APS-1 patients and matched healthy controls. The Th17 pathway was upregulated in response to C. albicans in APS-1 patients, whereas the IL-22 secretion was reduced. Autoantibodies against IL-22, IL-17A and IL-17F were detected in sera from APS-1 patients by immunoprecipitation. In addition, Aire-deficient (Aire(0/0) ) mice were much more susceptible than Aire(+/+) mice to mucosal candidiasis and C. albicans-induced Th17- and Th1-cell responses were increased in Aire(0/0) mice. Thus an excessive IL-17A reactivity towards C. albicans was observed in APS-1 patients and Aire(0/0) mice.
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| 17. |
- Ahumada, Sofía, et al.
(författare)
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Calibration of SO2 and NO2 Electrochemical Sensors via a Training and Testing Method in an Industrial Coastal Environment
- 2022
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Ingår i: Sensors. - : IVL Svenska Miljöinstitutet. - 1424-8220. ; 22:19, s. 7281-7281
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Tidskriftsartikel (refereegranskat)abstract
- Low-cost sensors can provide inaccurate data as temperature and humidity affect sensoraccuracy. Therefore, calibration and data correction are essential to obtain reliable measurements.This article presents a training and testing method used to calibrate a sensor module assembledfrom SO2 and NO2 electrochemical sensors (Alphasense B4 and B43F) alongside air temperature (T)and humidity (RH) sensors.Field training and testing were conducted in the industrialized coastalarea of Quintero Bay, Chile. The raw responses of the electrochemical (mV) and T-RH sensors weresubjected to multiple linear regression (MLR) using three data segments, based on either voltage(SO2 sensor) or temperature (NO2). The resulting MLR equations were used to estimate the referenceconcentration. In the field test, calibration improved the performance of the sensors after addingT and RH in a linear model.The most robust models for NO2 were associated with data collectedat T < 10 C (R2 = 0.85), while SO2 robust models (R2 = 0.97) were associated with data segmentscontaining higher voltages. Overall, this training and testing method reduced the bias due to T andHR in the evaluated sensors and could be replicated in similar environments to correct raw data fromlow-cost electrochemical sensors. A calibration method based on training and sensor testing afterrelocation is presented. The results show that the SO2 sensor performed better when modeled fordifferent segments of voltage data, and the NO2 sensor model performed better when calibrated fordifferent temperature data segments.
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| 18. |
- Alimohammadi, Mohammad, et al.
(författare)
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Autoimmune Polyendocrine Syndrome Type 1 : NALP5 in Autoimmune Polyendocrine Syndrome Type 1
- 2006
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Ingår i: The New England Journal of Medicine. ; 358:10, s. 1018-28
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Tidskriftsartikel (refereegranskat)abstract
- Background Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disorder caused by mutations in AIRE, the autoimmune regulator gene. Though recent studies concerning AIRE deficiency have begun to elucidate the molecular pathogenesis of organ-specific autoimmunity in patients with APS-1, the autoantigen responsible for hypoparathyroidism, a hallmark of APS-1 and its most common autoimmune endocrinopathy, has not yet been identified. Methods We performed immunoscreening of a human parathyroid complementary DNA library, using serum samples from patients with APS-1 and hypoparathyroidism, to identify patients with reactivity to the NACHT leucine-rich-repeat protein 5 (NALP5). Subsequently, serum samples from 87 patients with APS-1 and 293 controls, including patients with other autoimmune disorders, were used to determine the frequency and specificity of autoantibodies against NALP5. In addition, the expression of NALP5 was investigated in various tissues. Results NALP5-specific autoantibodies were detected in 49% of the patients with APS-1 and hypoparathyroidism but were absent in all patients with APS-1 but without hypoparathyroidism, in all patients with other autoimmune endocrine disorders, and in all healthy controls. NALP5 was predominantly expressed in the cytoplasm of parathyroid chief cells. Conclusions NALP5 appears to be a tissue-specific autoantigen involved in hypoparathyroidism in patients with APS-1. Autoantibodies against NALP5 appear to be highly specific and may be diagnostic for this prominent component of APS-1.
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| 19. |
- Alimohammadi, Mohammad, et al.
(författare)
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Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen
- 2008
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 358:10, s. 1018-1028
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disorder caused by mutations in AIRE, the autoimmune regulator gene. Though recent studies concerning AIRE deficiency have begun to elucidate the molecular pathogenesis of organ-specific autoimmunity in patients with APS-1, the autoantigen responsible for hypoparathyroidism, a hallmark of APS-1 and its most common autoimmune endocrinopathy, has not yet been identified. METHODS: We performed immunoscreening of a human parathyroid complementary DNA library, using serum samples from patients with APS-1 and hypoparathyroidism, to identify patients with reactivity to the NACHT leucine-rich-repeat protein 5 (NALP5). Subsequently, serum samples from 87 patients with APS-1 and 293 controls, including patients with other autoimmune disorders, were used to determine the frequency and specificity of autoantibodies against NALP5. In addition, the expression of NALP5 was investigated in various tissues. RESULTS: NALP5-specific autoantibodies were detected in 49% of the patients with APS-1 and hypoparathyroidism but were absent in all patients with APS-1 but without hypoparathyroidism, in all patients with other autoimmune endocrine disorders, and in all healthy controls. NALP5 was predominantly expressed in the cytoplasm of parathyroid chief cells. CONCLUSIONS: NALP5 appears to be a tissue-specific autoantigen involved in hypoparathyroidism in patients with APS-1. Autoantibodies against NALP5 appear to be highly specific and may be diagnostic for this prominent component of APS-1.
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| 20. |
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| 21. |
- Apel, Jan, 1965-, et al.
(författare)
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Fågelbacken och trattbägarsamhället : samhällsorganisation och rituella samlingsplatser vid övergången till en bofats tillvaro i östra Mellansverige
- 1995
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Ingår i: Tor. - Uppsala : Tor. - 0495-8772. ; 27, s. 47-132
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- A discussion of the TRB cultural landscape and form of society is attempted on the basis of the excavation of an Early Neolithic Funnel-beaker settlement site at Fågelbacken in eastern central Sweden. The site, situated on top of an esker, is characterized by finds of TRB pottery, quartz and flint debitage, pits with charred human bones, a cultbuilding and D-shaped huts. As a result of intra-site spatial analysis, ceramic analysis and a discussion of the site features, it is suggested that Fågelbacken should be interpreted not only as a coastal hunting site but also as a repeatedly visited, communal ritual site. A spatial analysis of thin-butted axes in the area surrounding the site, suggests that it is probably one of a whole series of similar, evenly spaced, ritual sites in the area. A sociocultural interpretation of Funnel-beaker huts and houses, together with an analysis of the distribution of stray finds of TRB type in the research area, further suggests that coastal sites like Fågelbacken are structurally related to groups of swidden-agriculture farmsteads and hunting stations in the interior.
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| 22. |
- Armerin, Fredrik, 1971-, et al.
(författare)
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Forecasting Ranking in Harness Racing Using Probabilities Induced by Expected Positions
- 2019
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Ingår i: Applied Artificial Intelligence. - : TAYLOR & FRANCIS INC. - 0883-9514 .- 1087-6545. ; 33:2, s. 171-189
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Tidskriftsartikel (refereegranskat)abstract
- Ranked events are pivotal in many important AI-applications such as Question Answering and recommendations systems. This paper studies ranked events in the setting of harness racing. For each horse there exists a probability distribution over its possible rankings. In the paper, it is shown that a set of expected positions (and more generally, higher moments) for the horses induces this probability distribution. The main contribution of the paper is a method, which extracts this induced probability distribution from a set of expected positions. An algorithm is proposed where the extraction of the induced distribution is given by the estimated expectations. MATLAB code is provided for the methodology. This approach gives freedom to model the horses in many different ways without the restrictions imposed by for instance logistic regression. To illustrate this point, we employ a neural network and ordinary ridge regression. The method is applied to predicting the distribution of the finishing positions for horses in harness racing. It outperforms both multinomial logistic regression and the market odds. The ease of use combined with fine results from the suggested approach constitutes a relevant addition to the increasingly important field of ranked events.
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| 23. |
- Bergfors, Linus, et al.
(författare)
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Datadriven diagnostik av avloppsledningsnät
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Det finns stor potential i att effektivare övervaka och styra pumpstationer i vatten- och avloppsledningsnät i de allra flesta städer och samhällen. Kan man tidigt upptäcka fel i pumpstationer eller onormala förhållanden i ledningsnätet kan man förbättra reningen samt undvika bräddning med vattenmängder som annars går ut orenade i miljön. Projektets mål är att utveckla metodik och verktyg för övervakning av pumpstationer för att säkerställa att driften är normal och ge tidiga varningar när en pumpstation får problem samt att ta fram en prioritering av var insatser för att minska tillskottsvattnet har störst effekt. Metodiken bygger på att jämföra drifttillståndet från historiska data under normala förhållanden med driftsförhållandet nu och se om man hittar avvikelser. Ett annat sätt att hitta avikelser på är att jämföra pumpstationens driftdata med närliggande pumpar eller pumpstationer för att se om förhållandet förändrats över tid vilket kan bero på slitage eller ökad mängd tillskottsvatten. Projektet har resulterat i konkreta verktyg som kan ha stor nytta vid kommunernas arbete med att förebygga problem i avloppledningsnätet. Vi kan nu göra en automatisk diagnosticering av ett pumpnätverk där användaren får ut vilka stationer som är särskilt drabbade av tillskottsvatten och där mycket kan vinnas på att sätta in åtgärder. Resultaten kan användas för att prioritera de områden där insatser kan göra störst skillnad både ekonomiskt och för miljön. I samband med detta får användaren dessutom ut en enkel uppskattning av hur mycket av det som pumpas som kommer från den faktiska förbrukningen på nätet. Vi har påvisat att drifttiderna i pumpstationerna är korrelerade med regnmängden i området och förhållandet kan anses vara kausalt. Tillsammans med korrelationerna mellan stationerna i avloppsnätet ger det viktig information om tidsförskjutningarna i systemet, vilket i sin tur är viktig för att kunna vidta preventiva åtgärder vid stora regnmängder. Uppföljning på trenden för pumpkvoten, som beräknas genom att ta kvoten mellan pumparna i samma pumpgrop vilka används växelvis, ger en indikation på drift av enskilda pumpar. Metodiken och verktygen kan göra det möjligt för användarna att övergå till behovsstyrt underhåll istället för att arbeta utifrån underhållsscheman. Det kan dessutom möjliggöra ett mer preventivt arbete med färre nödavledningar som följd och minskat antal nödutryckningar. Det krävs dock vidare utveckling för att få ut den fulla potentialen i tekniken. För att ta resultaten vidare behöver samarbetet med Borås Energi och Miljö fortsätta med regelbundna diagnostiseringar. I dagsläget finns det inget enkelt sätt för driftspersonalen att få ut resultaten från verktygen för diagnostisering. Nästa steg blir därför att utveckla ett användargränssnitt för att tillgängliggöra verktygen för användare i Sverige.
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| 24. |
- Blaesild, Paulina, 1994, et al.
(författare)
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Early Holocene vegetation development at Mesolithic fen dwelling sites in Dagsmosse, south-central Sweden, and its implications for understanding environment–human dynamics at various scales
- 2024
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - 0031-0182. ; 641
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Tidskriftsartikel (refereegranskat)abstract
- Recent discoveries of several Mesolithic sites within the Dagsmosse Basin, south-central Sweden, offer an opportunity to study the lifestyle and skillsets of Mesolithic hunter-gatherer-fishers operating in wetland environments. In this paper, we present a combined archaeological and palaeoecological analysis of a Mesolithic fenland environment using Repetitive-Proxy Pollen Analysis (RPPA) of early Holocene sequences. Based on comparison of stratigraphic profiles from two cores within the basin, we infer that the variance in pollen composition and anthropogenic signals reflect variability in human/vegetation interactions in the fenland, at different distances to the main human dwelling at Jussberg (9.0–8.2 ka cal BP). Our study describes the socio-environmental relations within the wetland and adjacent terrestrial areas, providing a basis for tracking changes in forager interactions with their surroundings during the Mesolithic. Pollen analysis is consistent with the previously established sequence of settlement phases and extent as well as providing new data concerning the anthropogenic impacts on plant communities within the wetland including the use, reuse, and management of vegetation taxa. Correlations between palaeoecological and archaeological data demonstrate that forager communities (i) prevailed in the open fenland landscape between 9.3 and 8.2 ka cal BP, (ii) actively altered taxa composition through small-scale clearings of pine (Pinus), birch (Betula) and sedges (Cyperaceae) and (iii) reduced canopy cover, possibly to intentionally encourage the growth of taxa such as hazel (Corylus), but that also promoted the establishment of pioneer plants such as mugwort (Artemisia) and bracken (Pteridium).
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| 25. |
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| 26. |
- Botner, Olga, et al.
(författare)
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Rapidity-Alignment and p_T Compensation of Particle Pairs in Hadronic Z^0 Decays
- 2002
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Ingår i: Phys. Lett.. - : Elsevier Science B.V.. - 0370-2693. ; B:533, s. 243-252
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Tidskriftsartikel (refereegranskat)abstract
- Observation is made of rapidity-alignment of K+K- and ppbar pairs which results from their asymmetric orientation in rapidity, with respect to the direction from primary quark to antiquark. The K+K- and ppbar data are consistent with predictions from the
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| 27. |
- Botner, Olga, et al.
(författare)
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Search for Charged Higgs Bosons in e+e- Collisions at sqrt(s) =189-202 GeV
- 2002
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Ingår i: Phys. Lett.. - : Elsevier Science B.V.. - 0370-2693. ; B:525, s. 17-28
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Tidskriftsartikel (refereegranskat)abstract
- A search for pair-produced charged Higgs bosons was performed in the high energy data collected by the DELPHI detector at LEP II at centre-of-mass energies from 189 GeV to 202 GeV. The three different final states taunutaunu, cscs and cstaunu were conside
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| 28. |
- Botner, Olga, et al.
(författare)
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Search for neutral MSSM Higgs bosons at LEP
- 2006
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Ingår i: Eur. Phys. J.. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 47, s. 547-
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Tidskriftsartikel (refereegranskat)
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| 29. |
- Botner, Olga, et al.
(författare)
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Searches for neutral Higgs bosons in e^+ e^- collisions from sqrt(s) = 191.6 to 201.7 GeV
- 2002
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Ingår i: Eur. Phys. J.. - : Springer-Verlag. - 1434-6044 .- 1434-6052. ; C:23, s. 409-435
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Tidskriftsartikel (refereegranskat)abstract
- Neutral Higgs bosons of the Standard Model (SM) and the Minimal Supersymmetric Standard Model (MSSM) were searched for in the data collected in 1999 by the DELPHI experiment at centre-of-mass energies between 191.6 and 201.7 GeV with a total integrated lu
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| 30. |
- Gummesson, Sara, et al.
(författare)
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Keep your head high : skulls on stakes and cranial trauma in Mesolithic Sweden
- 2018
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Ingår i: Antiquity. - : Antiquity Publications. - 0003-598X .- 1745-1744. ; 92:361, s. 74-90
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Tidskriftsartikel (refereegranskat)abstract
- The socio-cultural behaviour of Scandina-vian Mesolithic hunter-gatherers has been difficult to understand due to the dearth of sites thus far investigated. Recent excavations at Kanaljorden in Sweden, however, have revealed disarticulated human crania intentionally placed at the bottom of a former lake. The adult crania exhibited antemortem blunt force trauma patterns differentiated by sex that were probably the result of interpersonal violence; the remains of wooden stakes were recovered inside two crania, indicating that they had been mounted. Taphonomic factors suggest that the human bodies were manipulated prior to deposition. This unique site challenges our understanding of the handling of the dead during the European Mesolithic.
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| 31. |
- Haak, Wolfgang, et al.
(författare)
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Massive migration from the steppe was a source for Indo-European languages in Europe
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 522:7555, s. 207-
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Tidskriftsartikel (refereegranskat)abstract
- We generated genome-wide data from 69 Europeans who lived between 8,000-3,000 years ago by enriching ancient DNA libraries for a target set of almost 400,000 polymorphisms. Enrichment of these positions decreases the sequencing required for genome-wide ancient DNA analysis by a median of around 250-fold, allowing us to study an order of magnitude more individuals than previous studies(1-8) and to obtain new insights about the past. We show that the populations of Western and Far Eastern Europe followed opposite trajectories between 8,000-5,000 years ago. At the beginning of the Neolithic period in Europe, similar to 8,000-7,000 years ago, closely related groups of early farmers appeared in Germany, Hungary and Spain, different from indigenous hunter-gatherers, whereas Russia was inhabited by a distinctive population of hunter-gatherers with high affinity to a similar to 24,000-year-old Siberian(6). By similar to 6,000-5,000 years ago, farmers throughout much of Europe had more hunter-gatherer ancestry than their predecessors, but in Russia, the Yamnaya steppe herders of this time were descended not only from the preceding eastern European hunter-gatherers, but also from a population of Near Eastern ancestry. Western and Eastern Europe came into contact similar to 4,500 years ago, as the Late Neolithic Corded Ware people from Germany traced similar to 75% of their ancestry to the Yamnaya, documenting a massive migration into the heartland of Europe from its eastern periphery. This steppe ancestry persisted in all sampled central Europeans until at least similar to 3,000 years ago, and is ubiquitous in present-day Europeans. These results provide support for a steppe origin(9) of at least some of the Indo-European languages of Europe.
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| 32. |
- Hadrévi, Jenny, et al.
(författare)
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Systemic differences in serum metabolome : a cross sectional comparison of women with localised and widespread pain and controls
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal pain that started with chronic localised pain. The mechanism by which the transition from localised pain to widespread occurs is not clear, although many studies suggest it to be an altered metabolism. In this study, systemic metabolic differences between women with chronic localised neck-shoulder pain (NP), women with chronic widespread pain (CWP) and women who were healthy (CON) were assessed. Blood samples were analysed taking a metabolomics approach using gas chromatography mass spectrometry (GC-MS) and orthogonal partial least square discriminant analysis (OPLS-DA). The metabolomics analysis showed a clear systematic difference in the metabolic profiles between the subjects with NP and the CON but only a weak systematic difference between the subjects with CWP and the CON. This most likely reflects a difference in the portion of the metabolome influenced by the two pain conditions. In the NP group, the overall metabolic profile suggests that processes related to energy utilisation and lipid metabolism could be central aspects of mechanisms maintaining disorder.
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| 33. |
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| 34. |
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| 35. |
- Hallgren, Fredrik, 1968-
(författare)
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Early pottery among hunter-horticulturalists and hunter-gatherers in central Fenno-Scandinavia
- 2009
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Ingår i: Early Farmers, Late Foragers, and Ceramic Traditions. - Newcastle : Cambridge Scholars. - 9781443801591 ; , s. 215-238
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The hunter-gatherers of Mälardalen (eastern central Sweden) adopted ceramic technology at the same time as they adopted aspects of farming around 3900 cal. BC. The region thus appears to be a classic case of “Neolithisation”, with hunter-gatherers turning hunter-horticulturalists, adopting cereal cultivation and cattle herding along with the characteristic pottery of the Funnel Beaker Culture (albeit with local and regional peculiarities). Immediately to the north of the Funnel Beaker Culture (TRB) of Mälardalen, there lived hunter-gatherers of the northern Scandinavian Slate Culture that did not adopt either agriculture or pottery during the period in question. Thus, in central Scandinavia, there was formed a border between part-time farmers with pottery to the south, and hunter-gatherers without pottery to the north. However, while pottery was absent in Mälardalen before 3900 cal. BC, ceramics appeared already 5000 cal. BC immediately to the east, on Åland, a group of islands in the middle of the Baltic Sea. The oldest pottery along the eastern shores of the Baltic Sea, including the Åland archipelago, appeared in hunter-gatherer contexts, the centuries before 5000 cal. BC. During this time we have a contrast between hunter-gatherers with pottery to the east, and hunter-gatherers without pottery to the west. The Early Neolithic funnel-beaker pottery of Mälardalen display several peculiarities reminiscent of Comb Ware designs. Around 3300 cal. BC the eastern traits are accentuated with the introduction of pointed bottomed vessels and pits arranged in “chessmanner”, a pottery that is known as the Pitted Ware tradition. Parallel to these changes in the design of pottery, the settlement pattern was rearranged with a larger focus on aquatic resources and a diminishing role for agricultural practices.
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| 36. |
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| 37. |
- Hallgren, Fredrik, 1968-
(författare)
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Identitet i praktik : Lokala, regionala och överregionala sociala sammanhang inom nordlig trattbägarkultur
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis discusses the introduction of cultural practices such as cultivation, cattle herding, pottery craft and specific lithic traditions in the region around the Baltic Sea during the Stone Age. The main focus is on the Early Neolithic (4000-3300 cal. BC) Funnel Beaker Culture of Mälardalen and Bergslagen in eastern Central Sweden. Archaeological material from neighbouring parts of Scandinavia, Finland, Estonia, Latvia, Lithuania, northern Poland and northern Germany are also included in the discussion. The thesis does not attempt to explain why practices like agriculture and ceramic production were introduced, rather it discusses when and how they took place. The archaeological material is discussed as remains of activities like living, crafting, cultivating, herding – cultural practices that were created through participation and performance. It is argued that participation in these activities shaped aspects of the participants' identity.
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| 38. |
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| 39. |
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| 40. |
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| 41. |
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| 42. |
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| 43. |
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| 44. |
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| 45. |
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| 46. |
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| 47. |
- Henningsson, Frida, et al.
(författare)
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IgE-Mediated Enhancement of CD4(+) T Cell Responses in Mice Requires Antigen Presentation by CD11c(+) Cells and Not by B Cells
- 2011
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:7, s. e21760-
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Tidskriftsartikel (refereegranskat)abstract
- IgE antibodies, administered to mice together with their specific antigen, enhance antibody and CD4(+) T cell responses to this antigen. The effect is dependent on the low affinity receptor for IgE, CD23, and the receptor must be expressed on B cells. In vitro, IgE-antigen complexes are endocytosed via CD23 on B cells, which subsequently present the antigen to CD4(+) T cells. This mechanism has been suggested to explain also IgE-mediated enhancement of immune responses in vivo. We recently found that CD23(+) B cells capture IgE-antigen complexes in peripheral blood and rapidly transport them to B cell follicles in the spleen. This provides an alternative explanation for the requirement for CD23(+) B cells. The aim of the present study was to determine whether B-cell mediated antigen presentation of IgE-antigen complexes explains the enhancing effect of IgE on immune responses in vivo. The ability of spleen cells, taken from mice 1-4 h after immunization with IgE-antigen, to present antigen to specific CD4(+) T cells was analyzed. Antigen presentation was intact when spleens were depleted of CD19(+) cells (i.e., primarily B cells) but was severely impaired after depletion of CD11c(+) cells (i.e., primarily dendritic cells). In agreement with this, the ability of IgE to enhance proliferation of CD4(+) T cells was abolished in CD11c-DTR mice conditionally depleted of CD11c(+) cells. Finally, the lack of IgE-mediated enhancemen of CD4(+) T cell responses in CD23(-/-) mice could be rescued by transfer of MHC-II-compatible as well as by MHC-II-incompatible CD23(+) B cells. These findings argue against the idea that IgE-mediated enhancement of specific CD4(+) T cell responses in vivo is caused by increased antigen presentation by B cells. A model where CD23(+) B cells act as antigen transporting cells, delivering antigen to CD11c(+) cells for presentation to T cells is consistent with available experimental data.
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| 48. |
- Isaksson, Sven, et al.
(författare)
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Lipid residue analyses of Early Neolithic funnel-beaker pottery from Skogsmossen, eastern Central Sweden, and the earliest evidence of dairying in Sweden
- 2012
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 0305-4403 .- 1095-9238. ; 39:12, s. 3600-3609
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Tidskriftsartikel (refereegranskat)abstract
- This study address the question of the use and function of Early Neolithic (4000-3000 cal. BC) funnel-beaker pots from Malardalen in eastern Central Sweden. The material studied is pottery from a wetland offering at the site Skogsmossen in the province of Vastmanland. While deposited under ritual circumstances in a fen, the pots were likely used in a domestic domain on the settlement adjacent to the offering fen, prior to final deposition. The lipid analysis indicate a varied vessel use, there are traces of aquatic resources, plants, terrestrial animals and milk. The identification of milk residue is the oldest so far from Sweden.
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| 49. |
- Knutsson, Kjel, 1951-, et al.
(författare)
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The Mesolithic in Eastern Central Sweden
- 1999
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Ingår i: Universitetets Oldsakssamlings Skrifter. Ny rekke: The mesolithic of Central Scandinavia. ; 22
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Forskningsöversikt (populärvet., debatt m.m.)
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| 50. |
- Knutsson, Kjel, 1951-, et al.
(författare)
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The mesolithic in Eastern Central Sweden
- 1999
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Ingår i: Universitetets Oldsaksamlings Skrifter. - Oslo : Institut for arkeologi, kunsthistorie og numismatikk. - 0806-3907. ; 22:-, s. 87-125
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A survey of all Mesolithic sites in Eastern middle Sweden with a discussion of recent debates and new publications on c-14 datings, faunal assemblages, social networks, intra site analysis, lithic analysis.
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