| 1. |
- Loikas, Desirée, et al.
(författare)
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Does patient's sex influence treatment in primary care? Experiences and expressed knowledge among physicians : a qualitative study
- 2015
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Ingår i: BMC Family Practice. - London, UK : BioMed Central. - 1471-2296. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Biological and sociocultural differences between men and women may play an important role in medical treatment. Little is known about the awareness of these differences among general practitioners (GPs) and if they consider such differences in their medical practice. The aim of this study was to explore GPs' perception of sex and gender aspects in medical treatment.METHODS: We conducted five focus group discussions (FGDs) with 29 physicians (mainly GPs) in Sweden. A discussion guide with semi-structured questions was used. All FGDs were audio-recorded and transcribed word-by-word. Data were analysed through inductive thematic analysis with no predetermined categories.RESULTS: Three main categories emerged from the data. The first category emphasised GPs' experiences of sex and gender differences in diagnosing and assessment of clinical findings. Medical treatment in men and women was central in the second category. The third category emphasised GPs' knowledge of sex differences in drug therapy.CONCLUSIONS: The GPs stated they had little knowledge of sex and gender differences in drug treatment, but gave multiple examples of how the patient's sex affects the choice of treatment. Sex and gender aspects were considered in diagnosing and in the treatment decision. However, once the decision to treat was made the choice of drug followed recommendations by local Drug and Therapeutics Committee, which were perceived to be evidence-based. In the analysis we found a gap between perceived and expressed knowledge of sex and gender differences in drug treatment indicating a need of education about this to be included in the curriculum in medical school and in basic and specialist training for physicians. Education could also be a tool to avoid stereotypical thinking about male and female patients.
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| 2. |
- Nyblom, Anna Maria, 1975, et al.
(författare)
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Exceptional overproduction of a functional human membrane protein
- 2007
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Ingår i: Protein Expression and Purification. - : Elsevier BV. - 1046-5928 .- 1096-0279. ; 56:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Eukaryotic-especially human-membrane protein overproduction remains a major challenge in biochemistry. Heterologously overproduced and purified proteins provide a starting point for further biochemical, biophysical and structural studies, and the lack of sufficient quantities of functional membrane proteins is frequently a bottleneck hindering this. Here, we report exceptionally high production levels of a correctly folded and crystallisable recombinant human integral membrane protein in its active form; human aquaporin 1 (hAQP1) has been heterologously produced in the membranes of the methylotrophic yeast Pichia pastoris. After solubilisation and a two step purification procedure, at least 90 mg hAQP1 per liter of culture is obtained. Water channel activity of this purified hAQP was verified by reconstitution into proteoliposomes and performing stopped-flow vesicle shrinkage measurements. Mass spectrometry confirmed the identity of hAQPI in crude membrane preparations, and also from purified protein reconstituted into proteoliposomes. Furthermore, crystallisation screens yielded diffraction quality crystals of untagged recombinant hAQP1. This study illustrates the power of the yeast P. pastoris as a host to produce exceptionally high yields of a functionally active, human integral membrane protein for subsequent functional and structural characterization. (c) 2007 Elsevier Inc. All rights reserved.
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| 3. |
- Albrecht, Inka, et al.
(författare)
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Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies
- 2015
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Ingår i: Journal of Clinical Investigation. - : AMER SOC CLINICAL INVESTIGATION INC. - 0021-9738 .- 1558-8238. ; 125:12, s. 4612-4624
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Tidskriftsartikel (refereegranskat)abstract
- Mutations of the gene encoding four-and-a-half LIM domain 1 (FHL1) are the causative factor of several X-linked hereditary myopathies that are collectively termed FHL1-related myopathies. These disorders are characterized by severe muscle dysfunction and damage. Here, we have shown that patients with idiopathic inflammatory myopathies (IIMs) develop autoimmunity to FHL1, which is a muscle-specific protein. Anti-FHL1 autoantibodies were detected in 25% of IIM patients, while patients with other autoimmune diseases or muscular dystrophies were largely anti-FHL1 negative. Anti-FHL1 reactivity was predictive for muscle atrophy, dysphagia, pronounced muscle fiber damage, and vasculitis. FHL1 showed an altered expression pattern, with focal accumulation in the muscle fibers of autoantibody-positive patients compared with a homogeneous expression in anti-FHL1-negative patients and healthy controls. We determined that FHL1 is a target of the cytotoxic protease granzyme B, indicating that the generation of FHL1 fragments may initiate FHL1 autoimmunity. Moreover, immunization of myositis-prone mice with FHL1 aggravated muscle weakness and increased mortality, suggesting a direct link between anti-FHL1 responses and muscle damage. Together, our findings provide evidence that FHL1 may be involved in the pathogenesis not only of genetic FHL1-related myopathies but also of autoimmune IIM. Importantly, these results indicate that anti-FHL1 autoantibodies in peripheral blood have promising potential as a biomarker to identify a subset of severe IIM.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Andersson Sjöland, Annika, et al.
(författare)
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Versican in inflammation and tissue remodelling: the impact on lung disorders.
- 2015
-
Ingår i: Glycobiology. - : Oxford University Press (OUP). - 1460-2423 .- 0959-6658. ; 25:3, s. 243-251
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Forskningsöversikt (refereegranskat)abstract
- Versican is a proteoglycan that has many different roles in tissue homeostasis and inflammation. The biochemical structure is comprised of four different types of the core protein with attached glycosaminoglycans that can be sulphated to various extents and has the capacity to regulate differentiation of different cell types, migration, cell adhesion, proliferation, tissue stabilization and inflammation. Versican's regulatory properties are of importance during both homeostasis and changes that lead to disease progression. The glycosaminoglycans that are attached to the core protein are of the chondroitin sulfate/dermatan sulfate type and are known to be important in inflammation through interactions with cytokines and growth factors. For a more complex understanding of versican it is of importance to study the tissue niche, where the wound healing process in both healthy and diseased conditions take place. In previous studies our group has identified changes in the amount of the multifaceted versican in chronic lung disorders such as asthma, chronic obstructive pulmonary disease and bronchiolitis obliterans syndrome, which could be a result of pathologic, transforming growth factor β driven, on-going remodelling processes. Reversely, the context of versican in its niche is of great importance since versican has been reported to have a beneficial role in other contexts e.g. emphysema. Here we explore the vast mechanisms of versican in healthy lung and in lung disorders.
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| 8. |
- Axelsson, Karin, et al.
(författare)
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Pain among persons living at a nursing home
- 2000
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Ingår i: Vård i Norden. - : SAGE Publications. - 0107-4083 .- 1890-4238. ; 20:2, s. 20-23
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Tidskriftsartikel (refereegranskat)abstract
- Pain is common among elderly. Very sick elderly persons living in nursing homes often have communication problems because of dementia or stroke, which causes problem to judge pain and evaluate effects of pain treatment. The aim of this study was to describe the prevalence, localisation and expressions of pain and to evaluate the usefulness of some pain assessment methods for nursing home residents. The study included 66 elderly living in a nursing home of which 49% had dementia as main medical diagnosis. A specially trained registered nurse (RN) performed pain assessment by * presenting a set of pain assessment tools * interpreting the nursing home residents' reactions during activity and * interviewing the resident about perceived pain. Two physiotherapists (PTs) performed physical examination including assessment of joint motion and palpation of joints and muscles. Contractures and ambulating status were noted. Cognitive Performance Scale (CPS) assessed cognitive capacity. When assisted by the RN 61% of the residents used independent or by assistance a verbal rating scale. The RN made an estimation of pain in all the nursing home residents and the PTs examined 92% of the residents. Pain was identified in 88% of the residents, 42% of the residents were treated with analgesics and pain it-as documented in the nurses' daily notes in 27% of the patient records. All residents with contractures had pain in the engaged joint. This study indicates that it is possible to assess pain by combining interview and interpretation of the residents' reactions during activity. Detection of pain by physical examination is a valuable complement especially for persons with decreased ability to communicate.
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| 9. |
- Aybay, Erdem, et al.
(författare)
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Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
- 2023
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types. Gzms A and K are found in all jawed vertebrates and are the most well conserved of all hematopoietic serine proteases. Their potential functions have been studied extensively for many years, however, without clear conclusions. Gzm A was for many years thought to serve as a key component in the defense against viral infection by the induction of apoptosis in virus-infected cells, similar to gzm B. However, later studies have questioned this role and instead indicated that gzm A may act as a potent inducer of inflammatory cytokines and chemokines. Gzms A and K form clearly separate branches in a phylogenetic tree indicating separate functions. Transcriptional analyses presented here demonstrate the presence of gzm A and K transcripts in both CD4+ and CD8+ T cells. To enable screening for their primary biological targets we have made a detailed analysis of their extended cleavage specificities. Phage display analysis of the cleavage specificity of the recombinant enzymes showed that both gzms A and K are strict tryptases with high selectivity for Arg over Lys in the P1 position. The major differences in the specificities of these two enzymes are located N-terminally of the cleavage site, where gzm A prefers small amino acids such as Gly in the P3 position and shows a relatively relaxed selectivity in the P2 position. In contrast, gzm K prefers large amino acids such as Phe, Tyr, and Trp in both the P2 and P3 positions and does not tolerate negatively charged residues in the P2 position. This major distinction in extended specificities is likely reflected also in preferred in vivo targets of these two enzymes. This information can now be utilized for high-precision screening of primary targets for gzms A and K in search of their highly conserved but still poorly defined functions in vertebrate immunity.
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| 10. |
- Bagher, Mariam, et al.
(författare)
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Crosstalk between mast cells and lung fibroblasts is modified by alveolar extracellular matrix and influences epithelial migration
- 2021
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 22:2
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Tidskriftsartikel (refereegranskat)abstract
- Mast cells play an important role in asthma, however, the interactions between mast cells, fibroblasts and epithelial cells in idiopathic pulmonary fibrosis (IPF) are less known. The objectives were to investigate the effect of mast cells on fibroblast activity and migration of epithelial cells. Lung fibroblasts from IPF patients and healthy individuals were co-cultured with LAD2 mast cells or stimulated with the proteases tryptase and chymase. Human lung fibroblasts and mast cells were cultured on cell culture plastic plates or decellularized human lung tissue (scaffolds) to create a more physiological milieu by providing an alveolar extracellular matrix. Released mediators were analyzed and evaluated for effects on epithelial cell migration. Tryptase increased vascular endothelial growth factor (VEGF) release from fibroblasts, whereas co-culture with mast cells increased IL-6 and hepatocyte growth factor (HGF). Culture in scaffolds increased the release of VEGF compared to culture on plastic. Migration of epithelial cells was reduced by IL-6, while HGF and conditioned media from scaffold cultures promoted migration. In conclusion, mast cells and tryptase increased fibroblast release of mediators that influenced epithelial migration. These data indicate a role of mast cells and tryptase in the interplay between fibroblasts, epithelial cells and the alveolar extracellular matrix in health and lung disease.
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| 11. |
- Bagher, Mariam, et al.
(författare)
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Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
- 2018
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Ingår i: Cell Communication and Signaling. - : Springer Science and Business Media LLC. - 1478-811X. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-going remodeling processes. Protease activated receptor 2 (PAR2) expressed by fibroblasts may be activated by serine proteases, such as the mast cell mediator tryptase. The objective in this study was to investigate the effects of mast cells and specifically mast cell tryptase on fibroblast migration and the role of PAR2 activation. Methods: Human lung fibroblasts (HFL-1) were cultured together with human peripheral blood-derived mast cells or LAD2 mast cells and stimulated with either conditioned medium from LAD2 cells or tryptase. Analyses of immunological stimulation of mast cells by IgE/anti IgE in the co-culture system were also performed. The importance of PAR2 activation by mast cells and mast cell tryptase for the migratory effects of fibroblasts was investigated by pre-treatment with the PAR2 antagonist P2pal-18S. The expression of PAR2 was analyzed on fibroblasts and mast cells. Results: The migratory capacity of HFL-1 cells was enhanced by blood-derived mast cells (p < 0.02), LAD2 cells (p < 0.001), conditioned medium (p < 0.05) and tryptase (p < 0.006). P2pal-18S decreased the induced migration caused by mast cells (p < 0.001) and tryptase (p < 0.001) and the expression of PAR2 was verified in HFL-1 cells. Mast cells immunologically stimulated with IgE/Anti IgE had no further effects on fibroblast migration. Conclusions: Mast cells and the mast cell mediator tryptase may have crucial roles in inducing lung fibroblast migration via PAR-2 activation, which may contribute to remodeling processes in chronic lung diseases.
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| 12. |
- Beijer, Karin, et al.
(författare)
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Översättning av experimentella data till reella förhållanden.
- 1982
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I rapporten görs en litteraturgenomgång där resultat av olika effekt och upptagsförsök på kadmium jämförs. Spridningen i publicerade försöksresultat är mycket stor. Försöksbetingelserna är ofta bristfälligt angivna, vilket försvårar tydningen av resultaten. Såväl upptag som effekt är mycket kraftigt beroende av yttre faktorer (pH, hårdhet, etc). Ca 2+ förefaller vara den viktigaste yttre faktorn.
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| 13. |
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| 14. |
- Dalin, Frida, 1984-, et al.
(författare)
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Clinical and immunological characteristics of Autoimmune Addison's disease : a nationwide Swedish multicenter study
- 2017
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 102:2, s. 379-389
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Studies on clinical and immunological features of Autoimmune Addison's disease (AAD) are needed to understand the disease burden and increased mortality.OBJECTIVE: To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles and cardiovascular risk factors.DESIGN, SETTING AND PARTICIPANTS: Cross sectional, population-based study. 660 AAD patients were included utilizing the Swedish Addison Registry (SAR) 2008-2014. When analyzing cardiovascular risk factors, 3,594 individuals from the population-based survey in Northern Sweden, MONICA (MONItoring of Trends and Determinants of CArdiovascular Disease), served as controls.MAIN OUTCOME MEASURE: Prevalence of autoimmune comorbidities and cardiovascular risk factors. Autoantibodies against 13 autoantigens were determined.RESULTS: Sixty percent of the SAR cohort consisted of females. Mean age at diagnosis was significantly higher for females than for males (36.8 vs. 31.1 years). The proportion of 21-hydroxylase autoantibody positive patients was 83% and 62% of patients had one or more associated autoimmune diseases, more frequently coexisting in females (p<0.0001). AAD patients had lower BMI (p<0.0001) and prevalence of hypertension (p=0.027) compared with controls. Conventional hydrocortisone tablets were used by 89% of patients; with the mean dose 28.1±8.5 mg/day. The mean hydrocortisone equivalent dose normalized to body surface was 14.8±4.4 mg/m(2)/day. Higher hydrocortisone equivalent dose was associated with higher incidence of hypertension (p=0.046).CONCLUSIONS: Careful monitoring of AAD patients is warranted to detect associated autoimmune diseases. Contemporary Swedish AAD patients do not have increased prevalence of overweight, hypertension, T2DM or hyperlipidemia. However, high glucocorticoid replacement doses may be a risk factor for hypertension.
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| 15. |
- Eriksson, Gunilla, et al.
(författare)
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Diet and mobility among Mesolithic hunter-gatherers in Motala (Sweden) - The isotope perspective
- 2018
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 2352-409X .- 2352-4103. ; 17, s. 904-918
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Tidskriftsartikel (refereegranskat)abstract
- Recent excavations at the sites of Strandvägen and Kanaljorden in Motala, Eastern Central Sweden, have unearthed complex and varied funerary remains from the Mesolithic. The two sites are situated on opposite banks of the river Motala Ström. While geographically close and roughly covering the same time span (c. 8000–7000 cal. BP), the funerary remains reveal differences and similarities in the treatment of the dead between the two localities. While at Strandvägen human bones were mostly found either scattered along the river bed or in inhumation graves, Kanaljorden contains wetland depositions of disarticulated skulls. We have conducted multi-isotope analyses of δ13C, δ15N, δ34S and 87Sr/86Sr of human and animal remains with the aim of reconstructing the dietary patterns, geographic provenance and mobility of the interred. A series of faunal reference samples and, in the case of 87Sr/86Sr, soil samples have been analysed in order to establish relevant isotopic baselines. The results show a protein intake dominated by aquatic resources, probably consisting of both freshwater and marine fish in varied proportions. The strontium isotope data indicate an interesting distinction between the individuals buried on either side of the river Motala Ström. Five out of six sampled individuals from Strandvägen have isotope ratios consistent with a local provenance, whereas ratios from seven out of eight Kanaljorden individuals indicate a non-local origin. The δ34S analysis proved problematic as a majority of the samples appear to be affected by diagenesis. This is probably the result of contamination by exogenous sulphur from surrounding fluvial and lacustrine sediments, as has previously been reported from other waterlogged sites.
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| 16. |
- Eriksson, Ola, et al.
(författare)
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Krav på beslutsstöd för deltagande och konflikthantering vid skoglig planering
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport avser att, utifrån erfarenheter kring skogliga konflikter och intressemotsättningar, belysa vad ett beslutsstödssystem kan behöva ha för egenskaper. Erfarenheterna bygger i allt väsentligt på arbete som utförts inom ramen för projektet ”Konflikthantering i skogar med hög nyttjandetäthet” som finansierats av Skogssällskapet. Umeå juni 2010 Författarna
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| 17. |
- Evertsson, Maria
(författare)
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”Så vittna du om min mandom!” : Wilhelm Peterson-Bergers konstfilosofi och könsuppfattning, med särskild hänsyn till åren 1896-1913
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall purpose of this study is to elucidate Wilhelm Peterson-Berger’s perception of gender and how it is manifested in his philosophy of art. His perception of gender also incorporates conceptions of history, music and nationality. The research question is analysed primarily by reviewing Peterson-Berger’s writings from 1896 to 1913. The research is intended to shed new light on a previously overlooked area of research, using gender theory and discourse analysis. Peterson-Berger and his work have not been examined previously from a gender theory perspective. The research shows that Peterson-Berger was influenced in large measure by the prevailing ideals of his time, although he was in some ways more innovative than many of his contemporaries. Around the turn of the 20th century there was a great deal of focus on biology, with a clear distinction drawn between femininity and masculinity[1] . Masculinity was held up as an ideal, in contrast to femininity and effeminacy. Peterson-Berger advocated this distinction, and emphasized the biological distinction between [2] masculinity and femininity. However, a man need not always have all the characteristics that were considered typically masculine for his time, nor was it necessary for a woman to possess all the feminine characteristics typical of the female gender. According to Peterson-Berger, a woman could have a masculine soul, and vice versa. And although he often took a negative view of women, he granted musical recognition to singers who realized music in what was, to him, a masculine way. Moreover, the majority of Peterson-Berger’s close friends were women, and he dedicated many of his works to women.Theories of race and human evolution were circulating at the turn of the century, and clearly influenced Peterson-Berger. This study has shown that he pursued the writings of [3] Chamberlain[4] and Nietzsche. Incorporating elements of old Gothicist theories with ideas from the two aforementioned thinkers, Peterson-Berger constructed his own racial theory. He asserted that all peoples originated from the Nordic region, which he believed to be the birthplace of the entire human race. According to his theory, southern peoples were inferior[5] , with one exception, the Greeks, towards whom he was very positively disposed. This had to do with the ancient music drama, which Peterson-Berger believed had been created by inhabitants from the north who had migrated to Greece.Peterson-Berger’s notions about peoples from the north versus peoples from the south were interwoven with theories of sexuality. He believed that Germanic peoples were more sexually abstemious than southern Europeans, and that peoples who lived in the south were sexually dissolute. To indulge one’s sexuality was, in his view, a character flaw. Conversely, Peterson-Berger viewed asexuality as a masculine ideal, and believed it to be more common in the north. A number of contradictions have emerged in his perceptions of race and sexuality. A number of his perceptions with respect to gender roles, sexuality, nationalism and philosophy[6] are portrayed in his opera Arnljot, as are the contradictions inherent in them. For instance, the character Arnljot has many of the typical masculine characteristics held up as ideal, but nevertheless exhibits both weaknesses and deficiencies. This is reflected in both the music and the opera libretto.
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| 18. |
- Gil-Ramirez, Alicia, et al.
(författare)
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Efficient methodology for the extraction and analysis of lipids from porcine pulmonary artery by supercritical fluid chromatography coupled to mass spectrometry
- 2019
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Ingår i: Journal of Chromatography A. - : Elsevier BV. - 0021-9673. ; 1592, s. 173-182
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Tidskriftsartikel (refereegranskat)abstract
- Pulmonary artery grafts are needed as cardiovascular bioprosthetics. For successful tissue recellularization after transplantation, lipids have to be removed from the donor artery. Developing a selective process to remove lipids without damaging the extracellular matrix greatly depends on knowing the amount and type of lipid compounds in the specific tissue. Here we present an efficient methodology for the study of lipids present in porcine pulmonary arteries. The performance of six extraction methods to recover lipids from artery was evaluated. For this purpose, a supercritical fluid chromatography method coupled to quadrupole time-of-flight mass spectrometry detection (UHPSFC/QTOF-MS) was adapted. The method enabled separation of lipids of a wide range of polarity according to lipid class in less than 7 min. One dichloromethane-based extraction method was shown to be the most efficient one for the recovery of lipids from pulmonary artery. However, one MTBE-based extraction method was able to show the highest fatty acid extraction yields (to the expense of longer extraction times). Lipids were relative quantified according to class, and the major species within each class were identified. Triacylglycerols and glycerophospholipids were the most abundant classes, followed by sphingomyelins, monoacylglycerols and fatty acyls. The matrix effect exerted no interference on the analytical method, except for some few combinations of extraction method and lipid class. These results are of relevance for lipidomic studies from solid tissue, in particular for studies on pulmonary and cardiovascular diseases. Finally, our work sets the basis for the further development of a selective processes to remove lipids from pulmonary artery without damaging the tissue prior to transplantation.
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| 19. |
- Hallgren, Jenny, 1978-, et al.
(författare)
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Implementing a person centred collaborative health care model : A qualitative study on patient experiences
- 2021
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Ingår i: International Emergency Nursing. - : Elsevier. - 1755-599X .- 1878-013X. ; 59
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Tidskriftsartikel (refereegranskat)abstract
- Background: Collaborative Health Care (CHC) is a unique model in which ambulance services, home health care, hospital care and the national telephone helpline for healthcare in Sweden – Swedish health care direct (SHD1177) collaborate to provide the fastest possible health care for inhabitants living in eleven municipalities in western region of Sweden. Aim: To explore how patients experience and perceive health care received in the CHC. Method: Qualitative descriptive study using open-ended individual telephone interviews with fifteen community dwelling persons with experiences of care throughthe model CHC were conducted. Results: Two main categories and six subcategories were identified. The category “Thoughts of time in regard to acute health care” include “CHC leads to shorter waiting time for health care”, “Knowledge about the staff working hours” and “To alert or not alert”. The category “Thoughts on unplanned health care from CHC” involved “Receiving health care in my home”, ”Coordination from SHD1177 surprises” and “Accessibility of health care values higher than continuity”. Conclusion: Integrated health care models such as CHC are time saving and highly appreciated by community dwelling persons. The benefits of provision of coherent health care like in CHC, addresses the need to implement innovative integrated healthcare models in today's health care.
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| 20. |
- Hallgren, Karin, 1957-
(författare)
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Adolph Mecklin (1761-1803) : Biografi
- 2016
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Johan Adolph Mecklin föddes 22 maj 1761 i Linköping och dog 21 november 1803 i Norrköping. Han var domkyrkoorganist och director musices i Linköping från 1789 till sin död och rektor vid Trivialskolan i Norrköping från 1802. Han invaldes som ledamot i Kungl. Musikaliska akademien 1800.
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| 21. |
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| 22. |
- Hallgren, Karin, 1957-
(författare)
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Att förhålla sig till normen : kvinnor i Stockholms musikliv under 1800-talet
- 2019
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Ingår i: Tidig musik. - Stockholm : Föreningen för tidig musik. - 1400-5123. ; 39:1, s. 8-10
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- I 1800-talets borgerliga samhälle fördes en livlig debatt kring frågor som ”Vad passar sig för en kvinna att göra?” och ”Vilka rättigheter är det rimligt att en kvinna har?”
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| 23. |
- Hallgren, Karin, 1957-
(författare)
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August Berwald (1798−1869)
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- August Berwald föddes 24 augusti 1798 i Stockholm och avled 13 november 1869 i samma stad. Han var bror till tonsättaren Franz Berwald och kusin till Johan Fredrik Berwald. Som skicklig violinist var han anställd i Kungl. Hovkapellet 1815−60, från 1832 som konsertmästare. Han verkade också som konsertarrangör i Stockholm samt som chef för Kungl. Musikaliska akademiens undervisningsverk 1864−66.
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| 24. |
- Hallgren, Karin, 1957-
(författare)
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August Säfström (1813-1888) : Biografi / Biography
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- August Säfström was born in Uppsala on 1 October 1813 and died on 12 April 1888 in Stockholm. He worked for a time as a writer in a government agency and later on he entirely devoted himself to theatre productions in Stockholm. Säfström wrote and translated almost one hundred plays. Apart from composing the music to several plays, he also wrote songs with piano accompaniment.
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| 25. |
- Hallgren, Karin, 1957-
(författare)
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August Söderman (1832−1876)
- 2013
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Johan August Söderman föddes i Stockholm 17 juli 1832. Som tonåring fick han utbildning i harmonilära och piano vid Kungl. Musikaliska akademien. Praktisk erfarenhet erhöll han som kapellmästare vid resande teatersällskap under 1850-talet och senare som kormästare och biträdande kapellmästare vid Kungliga Teatern från 1860 fram till sin död, 10 februari 1876. Som kapellmästare vid teatern komponerade han en mängd stycken för teaterpjäser, men han skrev också vokala verk som solo- och körballader samt sånger. Dessa blev mycket uppskattade och inte minst kopplingen till det som uppfattades som folkton framhölls. Söderman var en uppskattad tonsättare i Stockholm vid 1800-talets mitt. Trots den korta levnadstiden är hans produktion omfattande och många verk framförs än idag. August Söderman invaldes den 24 februari 1865 i Kungl. Musikaliska akademien som ledamot nr 405.
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| 26. |
- Hallgren, Karin, 1957-
(författare)
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Berwald's Cantatas from the 1840's
- 2001
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Ingår i: Berwaldstudien. - Stockholm : Kungl. Musikaliska Akademien. ; , s. 121-125
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Konferensbidrag (refereegranskat)
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| 27. |
- Hallgren, Karin, 1957-
(författare)
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Borgerlighetens teater. Om verksamhet, musiker och repertoar på Mindre Teatern i Stockholm 1842-63.
- 2000
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The years around the middle of the nineteenth century were a time of change in Swedish politics, commerce and industry. The press became very influential in the debate, including the issue of the theatre and its role in society.With the theories on public opinion and a public sphere, formulated by Jürgen Habermas, as a starting point, three different aspects of the operations of the Mindre Teatern (the Minor Theatre) are discussed in this thesis.The first part deals with the theater and its role in society. Liberal demands for freedom of trade, also in the case of the theatre, caused strong criticism against the prevailing royal theatre monopoly. After several years of struggle the monopoly was broken by the establishment of the Mindre Teatern in 1842.The second part focuses on the musicians who were active at the theatre, and on the audience. The role of the professional musician in the middle of the nineteenth-century is discussed, and it is pointed out that most of the musicians at this time had to have several jobs of different kinds to earn their living. The relation between the audiences at the Mindre Teatern and the Kungliga Teatern (the Royal Theatre/Royal Opera House) is discussed, and it is noted that there were great similarities between the two audiences.Part three deals with the repertoire. Most of the almost 500 performed plays were of foreign origin, above all French. The majority of plays were comedies. The serious plays often had historical plots, and were set in national surroundings. The foreign plays were adapted to suit a Swedish audience. The interest in recognizable settings is noticeable in connection with the productions. The repertoire can be said to have contributed to defining the new middle class identity, an identity which also contained an element of national feeling. Even the music could be used for this purpose. The main part of the music pieces were arrangements, but new compositions, especially instrumental ones, occured to a lesser degree. What kind of play music could be used, was decided according to the customs of different genres. Instrumental pieces, for example, were mostly used in serious plays, whereas songs were much more commonly used in comic ones. The music is analysed with respect to both structural function and its role in creating atmosphere and character.
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| 28. |
- Hallgren, Karin, 1957-
(författare)
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Carl Stenborg (1752−1813) : Biografi / Biography
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Opera singer and theatre director Carl Stenborg was born in Stockholm on 8 September 1752, and died there on 1 August 1813. He joined his father's acting troupe while still in his teens, and in 1780 took over his theatre, which he went on to direct until 1799. Carl Stenborg was employed as a singer at the Royal Swedish Opera between 1773 and 1806, and was one of its most important lyrical actors. The majority of Stenborg's own compositions are comic operas or songs for such operas. He became a member of the Royal Swedish Academy of Music in 1782.
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| 29. |
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| 30. |
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| 31. |
- Hallgren, Karin, 1957-
(författare)
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Edouard Du Puy (ca 1770−1822)
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Jean Baptiste Edouard Louis Camille Du Puy föddes ca 1770 i Neuchâtel i Schweiz och avled 3 april 1822 i Stockholm. Han var där anställd i Kungl. Hovkapellet som konsertmästare 1793−99 och som hovkapellmästare 1812−22, mycket uppskattad som violinist, kapellmästare och även som sångare i ett flertal roller på scenen. Edouard Du Puy komponerade verk inom de flesta genrer från sällskapsvisor till scenisk musik i en franskinfluerad stil.
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| 32. |
- Hallgren, Karin, 1957-
(författare)
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Edvard Stjernström’s music theatre in Stockholm and Finland in the 1850s
- 2016
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- During the 19th century private theatres were established in Stockholm. They put on a popular repertoire and competed with the Royal theatre for a growing audience. An important theatre director in the middle of the 1800s was Edvard Stjernström. He owned a theatre in Stockholm and also made many tours to other cities in Sweden and Finland. Stjernström and his activities are the focus of this study. What was his role in deploying a repertoire to cities in Sweden and Finland? How did he choose the repertoire and the music? What relation did the plays and the music have to the debate about national identity? These questions will be discussed from a perspective of “public sphere” (Habermas) and national identity, but also from theories of distribution of a common European repertoire. Despite the national connection, the repertoire was to a great extent international. It is an interesting question how the repertoire was spread and a hypothesis is that individuals were of great importance in this respect. Stjernström is an example of such a person.For the study it is important to problematize the concept of “opera” and to show the great variety in music dramatic genres and performances, due to different interests and possibilities at different theatres. Light opera, with spoken dialogue was very popular and possible to perform with a smaller orchestra. This kind of repertoire was performed not only at the Royal theatre but also at several theatres in cities around Sweden and by travelling theatre companies.The theatre activities of Stjernström will in this article be compared to relevant theatres from other European countries. Not least will his tours to Finland be compared with his activities in Stockholm. The main sources for the study are play texts, music, posters from performances, accounts, and reviews and articles from contemporary papers.
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| 33. |
- Hallgren, Karin, 1957-
(författare)
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Emil Sjögren och legenden om Tannhäuser
- 2022
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Ingår i: Emil Sjögren - en vägvisare. - Möklinta : Gidlunds förlag. - 9789178445028 ; , s. 151-169
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 34. |
- Hallgren, Karin
(författare)
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En kåhltäppa eij at räkna : köksväxtodlingen i 1700-talets jordbrukssystem
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Bönders köksväxtodling är en del av 1700-talets svenska jordbrukssystem som inte har studerats i någon större utsträckning. Det råder därför en osäkerhet kring flera grundläggande frågor, som hur vanligt det var att bönder odlade köksväxter vid den här tiden, hur stora odlingslanden var, var de var belägna, vad som odlades, hur odlingen gick till och vilken inställningen var till odlingen under samtiden. De här frågorna behandlas i avhandlingen genom en omfattande källmaterialgenomgång av främst lantmäterikartor och trädgårds- och lantbrukslitteratur. Värderingen av de använda källorna utgör en viktig del av avhandlingen. I avhandlingen görs en systematisk genomgång av lantmäterikartor från större delen av Götaland och Svealand, vilken visar att kålgårdar eller kryddgårdar är redovisade för omkring 60 procent av de cirka 2 000 bebyggelseenheter som ingår i studien. Kartorna ger betydligt färre belägg för köksväxtland i den östra delen av området. Studien visar att förekomsten av det regelbundna tegskiftet solskifte bidrog till att köksväxtland inte blev karterade i lika stor utsträckning i öst, där lantmätarna prioriterade att mäta in byns åker- och äng och utelämnade de bebyggelsenära landskapselementen till förmån för de rektangulära tomternas gränser. De flesta köksväxtlanden var lokaliserade i närheten av bebyggelsen, men det förekom också att odlingslanden låg flera hundra meter från tomten. Större avstånd kunde motiveras av tillgången till vatten och av att skadedjurstrycket minskade. Köksväxt¬landens storlek var omkring 500 kvadratmeter i genomsnitt, men det var stora skillnader mellan och inom bebyggelseenheter. En regional studie i Västergötland visade att köksväxtlanden hade en i stort sett oförändrad storlek per gårdsbruk under 1700-talet. Delar av köksväxtlanden kunde ha andra funktioner än köksväxtodling, som frukt-, humle- eller hampaodling, eller vara bevuxna med gräs; hampan och gräset kan ha ingått i en cirkulation med köksväxterna. Avhandlingen visar att köksväxtodlingen var mycket spridd bland 1700-talets bönder och att den spelade en viktig roll i jordbrukssystemet bland annat genom att sprida gårdarnas risker i tid och rum.
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| 35. |
- Hallgren, Karin, 1957-
(författare)
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Eric Arrhén von Kapfelman (1790-1851)
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Eric Jacob Arrhén von Kapfelman föddes 21 oktober 1791 i Västervik. Han avlade studentexamen i Lund 1809 och tjänstgjorde som kanslist i kammarkollegiet och krigskollegiet från november 1816. Han var verksam som musiklärare vid Kungl. Krigsakademien på Karlberg från 1820 och utnämndes till musikdirektör 1833. Han invaldes som ledamot i Kungl. Musikaliska akademien 1841. Arrhén von Kapfelman var ogift. Han avled i Stockholm 23 maj 1851.
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| 36. |
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| 37. |
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| 38. |
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| 39. |
- Hallgren, Karin, 1957-
(författare)
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Fritz Söderman (1838−1883)
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Fredrik (Fritz) Adolph Christopher Söderman föddes 4 januari 1838 i Stockholm och avled 15 juli 1883 i samma stad. Han var verksam som cellist i Kungl. Hovkapellet större delen av sitt yrkesliv. Halvbrodern August Söderman var en framstående tonsättare. Fritz Södermans kompositioner består framför allt av sånger med pianoackompanjemang. Han blev ledamot av Kungl. Musikaliska akademien 1866.
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| 40. |
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| 41. |
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| 42. |
- Hallgren, Karin, 1957-
(författare)
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Hanna Brooman (1809-1887) : Biografi
- 2016
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Hanna Brooman föddes 21 augusti 1809 i Stockholm. Ingenting är känt om hennes föräldrar. Hon växte upp som fosterdotter till Jan Erik Brooman, skådespelare och sångare vid Kungl. Teatern. Under perioden 1847−84 var hon verksam som lärare vid Kungl. Teaterns elevskola. Hon avled i Stockholm 7 februari 1887.
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| 43. |
- Hallgren, Karin, 1957-
(författare)
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Ignaz Lachner (1807-1895)
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Den tyske tonsättaren och kapellmästaren Ignaz Lachner föddes 11 september 1807 i Rain, Bayern, och dog 24 februari 1895 i Hannover. Han kallades till Sverige av Kungl. Teaterns ledning sedan den tidigare hovkapellmästaren Jacopo Foroni hastigt avlidit. Efter tre säsonger 1858−61 återvände Ignaz Lachner till Tyskland. I Sverige komponerade han musik till ett par kungliga högtider och nyinstrumenterade Johann Gottlieb Naumanns opera Gustaf Wasa.
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| 44. |
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| 45. |
- Hallgren, Karin, 1957-
(författare)
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Inledning
- 2023
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Ingår i: Musik i rörelse. - Möklinta : Gidlunds förlag. - 9789178445141 ; , s. 7-10
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 46. |
- Hallgren, Karin, 1957-
(författare)
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Ivar Widéen (1871-1951) : Biografi / Biography
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Carl Ivar Natanael Widéen föddes 21 mars 1871 i Bällö i Småland och dog 16 mars 1951 i Lidköping. År 1900 domkyrkoorganist i Skara och verkade därefter i stadens musikliv drygt femtio år. Han komponerade företrädesvis sånger och körstycken. Ett stort antal verk tillkom även för kyrkoårets olika högtider. Widéen var under sin livstid en välkänd och uppskattad tonsättare av körmusik. Ledamot av Kungl. Musikaliska akademien 1921.
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| 47. |
- Hallgren, Karin, 1957-
(författare)
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Jacob Edvard Gille (1814−1880)
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Jacob Edvard Gille föddes 10 augusti 1814 i Stockholm och dog där 8 november 1880. Parallellt med sitt arbete som notarie vid bokauktionskammaren i Stockholm var han kontinuerligt verksam som musiker, bland annat vid Mindre teatern och Kungl. Hovkapellet samt som kyrkomusiker i katolska kyrkan. Gille skrev, förmodligen självlärd som tonsättare, musik i många genrer, från sånger till musikdramatik och symfonier.
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| 48. |
- Hallgren, Karin, 1957-
(författare)
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Jacob Niclas Ahlström (1805−1857)
- 2014
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Jacob Niclas Ahlström föddes i Visby 5 juni 1805 och avled i Stockholm 14 maj 1857. Han började tidigt verka som musiker, först inom kyrkan och som lärare, efterhand som teaterkapellmästare. Under åren 1842−54 var han verksam vid Nya teatern i Stockholm, där han skrev musik till ett drygt hundratal pjäser inom olika genrer. Huvuddelen av hans produktion är kopplad till teaterverksamheten. Därutöver har han också framför allt skrivit musik för manskör samt givit ut sångsamlingar för privat musicerande i hemmen.
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| 49. |
- Hallgren, Karin, 1957-
(författare)
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Johan Fredrik Berwald (1787−1861)
- 2014
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Johan Fredrik Berwald föddes i Stockholm 4 december 1787 och avled i Stockholm 26 augusti 1861. Violinist, tonsättare, dirigent. Kusin till tonsättaren Franz Berwald. Turnéer med fadern Georg Johan Abraham Berwald från 1795, medföljde fadern till S:t Petersburg 1803−12. Violinist i Hovkapellet från 1814, där han blev kapellmästare (tillf. 1822, ord. 1823−49). Ledamot av Kungl. Musikaliska akademien 1818. J.F. Berwald bidrog starkt till framväxten av ett offentligt musikliv i Stockholm, framför allt genom sina insatser som kör- och orkesterledare (förutom Hovkapellet även Harmoniska Sällskapet).
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| 50. |
- Hallgren, Karin, 1957-
(författare)
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Karin Lönegren (1871-1963) : Biografi / Biography
- 2016
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Karin Lönegren was born in Norrköping on 22 June 1871 and died in Stockholm on 20 February 1963. In the late 1880’s she moved with her family to Stockholm, where after studies with Richard Andersson and Franz Neruda she worked as a piano teacher and composer. Most of her compositions are works for piano, in addition to songs with piano accompaniment.
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