| 1. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 2. |
- Vos, Theo, et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
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Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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| 3. |
- Naghavi, Mohsen, et al.
(författare)
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Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 385:9963, s. 117-171
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Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specifi c all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specifi c causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute diff erences between countries decreased but relative diff erences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative diff erences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specifi c mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade.
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| 4. |
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| 5. |
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| 6. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 7. |
- Mahajan, Anubha, et al.
(författare)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Tidskriftsartikel (refereegranskat)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 8. |
- Marouli, Eirini, et al.
(författare)
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Rare and low-frequency coding variants alter human adult height
- 2017
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190
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Tidskriftsartikel (refereegranskat)abstract
- Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
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| 9. |
- Richards, Stephen, et al.
(författare)
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Genome Sequence of the Pea Aphid Acyrthosiphon pisum
- 2010
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 8:2, s. e1000313-
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Tidskriftsartikel (refereegranskat)abstract
- Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.
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| 10. |
- Turcot, Valerie, et al.
(författare)
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- 2018
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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| 11. |
- Aaboud, M, et al.
(författare)
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ATLAS Collaboration
- 2019
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Ingår i: XXVIIth International Conference on Ultrarelativistic Nucleus–Nucleus Collisions (Quark Matter 2018). - 0375-9474. ; 982, s. 985-1009
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Konferensbidrag (refereegranskat)
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| 12. |
- Aaboud, M, et al.
(författare)
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Combinations of single-top-quark production cross-section measurements and |f LV Vtb| determinations at √s = 7 and 8 TeV with the ATLAS and CMS experiments
- 2019
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2019:5
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the combinations of single-top-quark production cross-section measurements by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at s = 7 and 8 TeV corresponding to integrated luminosities of 1.17 to 5.1 fb−1 at s = 7 TeV and 12.2 to 20.3 fb−1 at s = 8 TeV. These combinations are performed per centre-of-mass energy and for each production mode: t-channel, tW, and s-channel. The combined t-channel cross-sections are 67.5 ± 5.7 pb and 87.7 ± 5.8 pb at s = 7 and 8 TeV respectively. The combined tW cross-sections are 16.3 ± 4.1 pb and 23.1 ± 3.6 pb at s = 7 and 8 TeV respectively. For the s-channel cross-section, the combination yields 4.9 ± 1.4 pb at s = 8 TeV. The square of the magnitude of the CKM matrix element Vtb multiplied by a form factor fLV is determined for each production mode and centre-of-mass energy, using the ratio of the measured cross-section to its theoretical prediction. It is assumed that the top-quark-related CKM matrix elements obey the relation |Vtd|, |Vts| ≪ |Vtb|. All the |fLVVtb|2 determinations, extracted from individual ratios at s = 7 and 8 TeV, are combined, resulting in |fLVVtb| = 1.02 ± 0.04 (meas.) ± 0.02 (theo.). All combined measurements are consistent with their corresponding Standard Model predictions.[Figure not available: see fulltext.]. © 2019, The Author(s).
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| 13. |
- Aaboud, M, et al.
(författare)
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Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ⁎ → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- 2018
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 786, s. 114-133
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Tidskriftsartikel (refereegranskat)abstract
- A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ⁎→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions. © 2018 The Author(s)
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| 14. |
- Aaboud, M, et al.
(författare)
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Constraints on mediator-based dark matter and scalar dark energy models using √s = 13 TeV pp collision data collected by the ATLAS detector
- 2019
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2019:5
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Tidskriftsartikel (refereegranskat)abstract
- Constraints on selected mediator-based dark matter models and a scalar dark energy model using up to 37 fb−1s = 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015-2016 are summarised in this paper. The results of experimental searches in a variety of final states are interpreted in terms of a set of spin-1 and spin-0 single-mediator dark matter simplified models and a second set of models involving an extended Higgs sector plus an additional vector or pseudo-scalar mediator. The searches considered in this paper constrain spin-1 leptophobic and leptophilic mediators, spin-0 colour-neutral and colour-charged mediators and vector or pseudo-scalar mediators embedded in extended Higgs sector models. In this case, also s = 8 TeV pp collision data are used for the interpretation of the results. The results are also interpreted for the first time in terms of light scalar particles that could contribute to the accelerating expansion of the universe (dark energy).[Figure not available: see fulltext.]. © 2019, The Author(s).
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| 15. |
- Aaboud, M, et al.
(författare)
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Fluctuations of anisotropic flow in Pb+Pb collisions at √sNN = 5.02 TeV with the ATLAS detector
- 2020
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2020:1
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Tidskriftsartikel (refereegranskat)abstract
- Multi-particle azimuthal cumulants are measured as a function of centrality and transverse momentum using 470 μb−1 of Pb+Pb collisions at sNN = 5.02 TeV with the ATLAS detector at the LHC. These cumulants provide information on the event-by-event fluctuations of harmonic flow coefficients vn and correlated fluctuations between two harmonics vn and vm. For the first time, a non-zero four-particle cumulant is observed for dipolar flow, v1. The four-particle cumulants for elliptic flow, v2, and triangular flow, v3, exhibit a strong centrality dependence and change sign in ultra-central collisions. This sign change is consistent with significant non-Gaussian fluctuations in v2 and v3. The four-particle cumulant for quadrangular flow, v4, is found to change sign in mid-central collisions. Correlations between two harmonics are studied with three- and four-particle mixed-harmonic cumulants, which indicate an anti-correlation between v2 and v3, and a positive correlation between v2 and v4. These correlations decrease in strength towards central collisions and either approach zero or change sign in ultra-central collisions. To investigate the possible flow fluctuations arising from intrinsic centrality or volume fluctuations, the results are compared between two different event classes used for centrality definitions. In peripheral and mid-central collisions where the cumulant signals are large, only small differences are observed. In ultra-central collisions, the differences are much larger and transverse momentum dependent. These results provide new information to disentangle flow fluctuations from the initial and final states, as well as new insights on the influence of centrality fluctuations. [Figure not available: see fulltext.]. © 2020, The Author(s).
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| 16. |
- Aaboud, M, et al.
(författare)
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Measurement of colour flow using jet-pull observables in tt¯ events with the ATLAS experiment at √s=13TeV
- 2018
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:10
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown that weighted angular moments derived from jet constituents encode the colour connections between partons that seed the jets. This paper presents measurements of two such distributions, the jet-pull angle and jet-pull magnitude, both of which are derived from the jet-pull angular moment. The measurement is performed in tt¯ events with one leptonically decaying W boson and one hadronically decaying W boson, using 36.1fb-1 of pp collision data recorded by the ATLAS detector at s=13TeV delivered by the Large Hadron Collider. The observables are measured for two dijet systems, corresponding to the colour-connected daughters of the W boson and the two b-jets from the top-quark decays, which are not expected to be colour connected. To allow the comparison of the measured distributions to colour model predictions, the measured distributions are unfolded to particle level, after correcting for experimental effects introduced by the detector. While good agreement can be found for some combinations of predictions and observables, none of the predictions describes the data well across all observables. © 2018, CERN for the benefit of the ATLAS collaboration.
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| 17. |
- Aaboud, M, et al.
(författare)
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Measurement of fiducial and differential W+W- production cross-sections at √s=13 TeV with the ATLAS detector
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:10
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of fiducial and differential cross-sections for W+W- production in proton–proton collisions at s=13 TeV with the ATLAS experiment at the Large Hadron Collider using data corresponding to an integrated luminosity of 36.1 fb - 1 is presented. Events with one electron and one muon are selected, corresponding to the decay of the diboson system as WW→ e±νμ∓ν. To suppress top-quark background, events containing jets with a transverse momentum exceeding 35 GeV are not included in the measurement phase space. The fiducial cross-section, six differential distributions and the cross-section as a function of the jet-veto transverse momentum threshold are measured and compared with several theoretical predictions. Constraints on anomalous electroweak gauge boson self-interactions are also presented in the framework of a dimension-six effective field theory. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 18. |
- Aaboud, M, et al.
(författare)
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Measurement of prompt photon production in sNN=8.16 TeV p + Pb collisions with ATLAS
- 2019
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 796, s. 230-252
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Tidskriftsartikel (refereegranskat)abstract
- The inclusive production rates of isolated, prompt photons in p+Pb collisions at sNN=8.16 TeV are studied with the ATLAS detector at the Large Hadron Collider using a dataset with an integrated luminosity of 165 nb−1 recorded in 2016. The cross-section and nuclear modification factor RpPb are measured as a function of photon transverse energy from 20 GeV to 550 GeV and in three nucleon–nucleon centre-of-mass pseudorapidity regions, (−2.83,−2.02), (−1.84,0.91), and (1.09,1.90). The cross-section and RpPb values are compared with the results of a next-to-leading-order perturbative QCD calculation, with and without nuclear parton distribution function modifications, and with expectations based on a model of the energy loss of partons prior to the hard scattering. The data disfavour a large amount of energy loss and provide new constraints on the parton densities in nuclei. © 2019 The Author
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| 19. |
- Aaboud, M, et al.
(författare)
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Measurement of the azimuthal anisotropy of charged particles produced in √sNN = 5.02 TeV Pb+Pb collisions with the ATLAS detector
- 2018
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:12
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the azimuthal anisotropy in lead–lead collisions at sNN = 5.02 TeV are presented using a data sample corresponding to 0.49 nb - 1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5 < pT< 60 GeV, the pseudorapidity, | η| < 2.5, and the collision centrality 0–80%. Results from different methods are compared and discussed in the context of previous and recent measurements in Pb+Pb collisions at sNN = 2.76 TeV and 5.02 TeV. In particular, the shape of the pTdependence of elliptic or triangular flow harmonics is observed to be very similar at different centralities after scaling the vn and pTvalues by constant factors over the centrality interval 0–60% and the pTrange 0.5 < pT< 5 GeV. © 2018, CERN for the benefit of the ATLAS collaboration.
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| 20. |
- Aaboud, M, et al.
(författare)
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Measurement of the Higgs boson mass in the H → ZZ⁎ → 4ℓ and H → γγ channels with s=13 TeV pp collisions using the ATLAS detector
- 2018
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 784, s. 345-366
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Tidskriftsartikel (refereegranskat)abstract
- The mass of the Higgs boson is measured in the H→ZZ⁎→4ℓ and in the H→γγ decay channels with 36.1 fb−1 of proton–proton collision data from the Large Hadron Collider at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector in 2015 and 2016. The measured value in the H→ZZ⁎→4ℓ channel is mH ZZ⁎=124.79±0.37GeV, while the measured value in the H→γγ channel is mH γγ=124.93±0.40GeV. Combining these results with the ATLAS measurement based on 7 and 8 TeV proton–proton collision data yields a Higgs boson mass of mH=124.97±0.24GeV. © 2018 The Author
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| 21. |
- Aaboud, M, et al.
(författare)
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Measurement of the top quark mass in the tt¯ → lepton+jets channel from √s=8 TeV ATLAS data and combination with previous results
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:4
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Tidskriftsartikel (refereegranskat)abstract
- The top quark mass is measured using a template method in the tt¯ → lepton + jets channel (lepton is e or μ) using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton–proton centre-of-mass energy of s=8 TeV and correspond to an integrated luminosity of 20.2 fb - 1 . The tt¯ → lepton + jets channel is characterized by the presence of a charged lepton, a neutrino and four jets, two of which originate from bottom quarks (b). Exploiting a three-dimensional template technique, the top quark mass is determined together with a global jet energy scale factor and a relative b-to-light-jet energy scale factor. The mass of the top quark is measured to be mtop=172.08±0.39(stat)±0.82(syst) GeV. A combination with previous ATLAS m top measurements gives mtop=172.69±0.25(stat)±0.41(syst) GeV. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 22. |
- Aaboud, M, et al.
(författare)
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Measurement of ZZ production in the ℓℓνν final state with the ATLAS detector in pp collisions at √s = 13 TeV
- 2019
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2019:10
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a measurement of ZZ production with the ATLAS detector at the Large Hadron Collider. The measurement is carried out in the final state with two charged leptons and two neutrinos, using data collected during 2015 and 2016 in pp collisions at s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. The integrated cross-sections in the total and fiducial phase spaces are measured with an uncertainty of 7% and compared with Standard Model predictions, and differential measurements in the fiducial phase space are reported. No significant deviations from the Standard Model predictions are observed, and stringent constraints are placed on anomalous couplings corresponding to neutral triple gauge-boson interactions. [Figure not available: see fulltext.]. © 2019, The Author(s).
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| 23. |
- Aaboud, M, et al.
(författare)
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Measurements of b-jet tagging efficiency with the ATLAS detector using tt¯ events at √s=13 TeV
- 2018
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2018:8
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Tidskriftsartikel (refereegranskat)abstract
- The efficiency to identify jets containing b-hadrons (b-jets) is measured using a high purity sample of dileptonic top quark-antiquark pairs (tt¯) selected from the 36.1 fb−1 of data collected by the ATLAS detector in 2015 and 2016 from proton-proton collisions produced by the Large Hadron Collider at a centre-of-mass energy s=13 TeV. Two methods are used to extract the efficiency from tt¯ events, a combinatorial likelihood approach and a tag-and-probe method. A boosted decision tree, not using b-tagging information, is used to select events in which two b-jets are present, which reduces the dominant uncertainty in the modelling of the flavour of the jets. The efficiency is extracted for jets in a transverse momentum range from 20 to 300 GeV, with data-to-simulation scale factors calculated by comparing the efficiency measured using collision data to that predicted by the simulation. The two methods give compatible results, and achieve a similar level of precision, measuring data-to-simulation scale factors close to unity with uncertainties ranging from 2% to 12% depending on the jet transverse momentum. © 2018, The Author(s).
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| 24. |
- Aaboud, M, et al.
(författare)
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Measurements of gluon–gluon fusion and vector-boson fusion Higgs boson production cross-sections in the H → WW⁎ → eνμν decay channel in pp collisions at √s=13TeV with the ATLAS detector
- 2019
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 789, s. 508-529
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Tidskriftsartikel (refereegranskat)abstract
- Higgs boson production cross-sections in proton–proton collisions are measured in the H→WW⁎→eνμν decay channel. The proton–proton collision data were produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector in 2015 and 2016, corresponding to an integrated luminosity of 36.1fb−1. The product of the H→WW⁎ branching fraction times the gluon–gluon fusion and vector-boson fusion cross-sections are measured to be 11.4−1.1 +1.2(stat.)−1.7 +1.8(syst.)pb and 0.50−0.22 +0.24(stat.)±0.17(syst.)pb, respectively, in agreement with Standard Model predictions. © 2019 The Author
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| 25. |
- Aaboud, M, et al.
(författare)
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Measurements of inclusive and differential fiducial cross-sections of tt¯ production with additional heavy-flavour jets in proton-proton collisions at √s = 13 TeV with the ATLAS detector
- 2019
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2019:4
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents measurements of tt¯ production in association with additional b-jets in pp collisions at the LHC at a centre-of-mass energy of 13 TeV. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb −1 . Fiducial cross-section measurements are performed in the dilepton and lepton-plus-jets tt¯ decay channels. Results are presented at particle level in the form of inclusive cross-sections of tt¯ final states with three and four b-jets as well as differential cross-sections as a function of global event properties and properties of b-jet pairs. The measured inclusive fiducial cross-sections generally exceed the tt¯ bb¯ predictions from various next-to-leading-order matrix element calculations matched to a parton shower but are compatible within the total uncertainties. The experimental uncertainties are smaller than the uncertainties in the predictions. Comparisons of state-of-the-art theoretical predictions with the differential measurements are shown and good agreement with data is found for most of them.[Figure not available: see fulltext.]. © 2019, The Author(s).
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| 26. |
- Aaboud, M, et al.
(författare)
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Measurements of inclusive and differential fiducial cross-sections of tt¯ γ production in leptonic final states at √s=13TeV in ATLAS
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:5
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive and differential cross-sections for the production of a top-quark pair in association with a photon are measured with proton-proton collision data corresponding to an integrated luminosity of 36.1 fb-1, collected by the ATLAS detector at the LHC in 2015 and 2016 at a centre-of-mass energy of 13 TeV. The measurements are performed in single-lepton and dilepton final states in a fiducial volume. Events with exactly one photon, one or two leptons, a channel-dependent minimum number of jets, and at least one b-jet are selected. Neural network algorithms are used to separate the signal from the backgrounds. The fiducial cross-sections are measured to be 521±9(stat.)±41(sys.)fb and 69±3(stat.)±4(sys.)fb for the single-lepton and dilepton channels, respectively. The differential cross-sections are measured as a function of photon transverse momentum, photon absolute pseudorapidity, and angular distance between the photon and its closest lepton in both channels, as well as azimuthal opening angle and absolute pseudorapidity difference between the two leptons in the dilepton channel. All measurements are in agreement with the theoretical predictions. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 27. |
- Aaboud, M, et al.
(författare)
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Observation of H→bb¯ decays and VH production with the ATLAS detector
- 2018
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 786, s. 59-86
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Tidskriftsartikel (refereegranskat)abstract
- A search for the decay of the Standard Model Higgs boson into a bb¯ pair when produced in association with a W or Z boson is performed with the ATLAS detector. The data, corresponding to an integrated luminosity of 79.8fb−1 were collected in proton–proton collisions during Run 2 of the Large Hadron Collider at a centre-of-mass energy of 13TeV. For a Higgs boson mass of 125GeV, an excess of events over the expected background from other Standard Model processes is found with an observed (expected) significance of 4.9 (4.3) standard deviations. A combination with the results from other searches in Run 1 and in Run 2 for the Higgs boson in the bb¯ decay mode is performed, which yields an observed (expected) significance of 5.4 (5.5) standard deviations, thus providing direct observation of the Higgs boson decay into b-quarks. The ratio of the measured event yield for a Higgs boson decaying into bb¯ to the Standard Model expectation is 1.01±0.12(stat.)−0.15 +0.16(syst.). Additionally, a combination of Run 2 results searching for the Higgs boson produced in association with a vector boson yields an observed (expected) significance of 5.3 (4.8) standard deviations. © 2018 The Author(s)
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| 28. |
- Aaboud, M, et al.
(författare)
-
Search for charged Higgs bosons decaying via H ± → τ ± ντ in the τ+jets and τ+lepton final states with 36 fb−1 of pp collision data recorded at √s=13 TeV with the ATLAS experiment
- 2018
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2018:9
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Tidskriftsartikel (refereegranskat)abstract
- Charged Higgs bosons produced either in top-quark decays or in association with a top-quark, subsequently decaying via H± → τ±ντ, are searched for in 36.1 fb−1 of proton-proton collision data at s=13 TeV recorded with the ATLAS detector. Depending on whether the top-quark produced together with H± decays hadronically or leptonically, the search targets τ+jets and τ+lepton final states, in both cases with a hadronically decaying τ-lepton. No evidence of a charged Higgs boson is found. For the mass range of mH± = 90–2000 GeV, upper limits at the 95% confidence level are set on the production cross-section of the charged Higgs boson times the branching fraction ℬ (H±→ τ±ντ) in the range 4.2–0.0025 pb. In the mass range 90–160 GeV, assuming the Standard Model cross-section for tt¯ production, this corresponds to upper limits between 0.25% and 0.031% for the branching fraction ℬ(t→bH±)×ℬ(H±→τ±ντ).[Figure not available: see fulltext.] © 2018, The Author(s).
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| 29. |
- Aaboud, M, et al.
(författare)
-
Search for Higgs boson decays into a pair of light bosons in the bbμμ final state in pp collision at √s=13TeV with the ATLAS detector
- 2019
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 790, s. 1-21
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Tidskriftsartikel (refereegranskat)abstract
- A search for decays of the Higgs boson into a pair of new spin-zero particles, H→aa, where the a-bosons decay into a b-quark pair and a muon pair, is presented. The search uses 36.1 fb−1 of proton–proton collision data at s=13 TeV recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the Standard Model prediction is observed. Upper limits at 95% confidence level are placed on the branching ratio (σH/σSM)×B(H→aa→bbμμ), ranging from 1.2×10−4 to 8.4×10−4 in the a-boson mass range of 20–60 GeV. Model-independent limits are set on the visible production cross-section times the branching ratio to the bbμμ final state for new physics, σvis(X)×B(X→bbμμ), ranging from 0.1 fb to 0.73 fb for mμμ between 18 and 62 GeV. © 2018 The Author
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| 30. |
- Aaboud, M, et al.
(författare)
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Search for Higgs boson decays into pairs of light (pseudo)scalar particles in the γγjj final state in pp collisions at s=13TeV with the ATLAS detector
- 2018
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 782, s. 750-767
-
Tidskriftsartikel (refereegranskat)abstract
- This Letter presents a search for exotic decays of the Higgs boson to a pair of new (pseudo)scalar particles, H→aa, where the a particle has a mass in the range 20–60 GeV, and where one of the a bosons decays into a pair of photons and the other to a pair of gluons. The search is performed in event samples enhanced in vector-boson fusion Higgs boson production by requiring two jets with large invariant mass in addition to the Higgs boson candidate decay products. The analysis is based on the full dataset of pp collisions at s=13TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 36.7 fb−1. The data are in agreement with the Standard Model predictions and an upper limit at the 95% confidence level is placed on the production cross section times the branching ratio for the decay H→aa→γγgg. This limit ranges from 3.1 pb to 9.0 pb depending on the mass of the a boson. © 2018 The Author
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| 31. |
- Aaboud, M, et al.
(författare)
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Search for Higgs boson pair production in the bb¯ WW * decay mode at √s = 13 TeV with the ATLAS detector
- 2019
-
Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2019:4
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Tidskriftsartikel (refereegranskat)abstract
- A search for Higgs boson pair production in the bb¯ WW * decay mode is performed in the bb¯ ℓνqq final state using 36.1 fb −1 of proton-proton collision data at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. No evidence of events beyond the background expectation is found. Upper limits on the non-resonant pp → HH production cross section of 10 pb and on the resonant production cross section as a function of the HH invariant mass are obtained. Resonant production limits are set for scalar and spin-2 graviton hypotheses in the mass range 500 to 3000 GeV.[Figure not available: see fulltext.] © 2019, The Author(s).
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| 32. |
- Aaboud, M, et al.
(författare)
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Search for Higgs boson pair production in the γ γ bb¯ final state with 13 TeV pp collision data collected by the ATLAS experiment
- 2018
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2018:11
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Tidskriftsartikel (refereegranskat)abstract
- A search is performed for resonant and non-resonant Higgs boson pair production in the γ γ bb¯ final state. The data set used corresponds to an integrated luminosity of 36.1 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess relative to the Standard Model expectation is observed. The observed limit on the non-resonant Higgs boson pair cross-section is 0.73 pb at 95% confidence level. This observed limit is equivalent to 22 times the predicted Standard Model cross-section. The Higgs boson self-coupling (κλ = λHHH/λHHH SM) is constrained at 95% confidence level to −8.2 < κλ < 13.2. For resonant Higgs boson pair production through X→ HH→ γ γ bb¯ , the limit is presented, using the narrow-width approximation, as a function of mX in the range 260 GeV < mX < 1000 GeV. The observed limits range from 1.1 pb to 0.12 pb over this mass range. © 2018, The Author(s).
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| 33. |
- Aaboud, M, et al.
(författare)
-
Search for pair production of Higgs bosons in the bb¯ bb¯ final state using proton-proton collisions at √s=13 TeV with the ATLAS detector
- 2019
-
Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2019:1
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Tidskriftsartikel (refereegranskat)abstract
- A search for Higgs boson pair production in the bb¯ bb¯ final state is carried out with up to 36.1 fb−1 of LHC proton-proton collision data collected at s=13 TeV with the ATLAS detector in 2015 and 2016. Three benchmark signals are studied: a spin-2 graviton decaying into a Higgs boson pair, a scalar resonance decaying into a Higgs boson pair, and Standard Model non-resonant Higgs boson pair production. Two analyses are carried out, each implementing a particular technique for the event reconstruction that targets Higgs bosons reconstructed as pairs of jets or single boosted jets. The resonance mass range covered is 260–3000 GeV. The analyses are statistically combined and upper limits on the production cross section of Higgs boson pairs times branching ratio to bb¯ bb¯ are set in each model. No significant excess is observed; the largest deviation of data over prediction is found at a mass of 280 GeV, corresponding to 2.3 standard deviations globally. The observed 95% confidence level upper limit on the non-resonant production is 13 times the Standard Model prediction.[Figure not available: see fulltext.]. © 2019, The Author(s).
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| 34. |
- Aaboud, M, et al.
(författare)
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Search for Resonant and Nonresonant Higgs Boson Pair Production in the b b τ+τ- Decay Channel in pp Collisions at s =13 TeV with the ATLAS Detector
- 2018
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Ingår i: Physical Review Letters. - 1079-7114. ; 121:19
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Tidskriftsartikel (refereegranskat)abstract
- A search for resonant and nonresonant pair production of Higgs bosons in the bbτ+τ- final state is presented. The search uses 36.1 fb-1 of pp collision data with s=13 TeV recorded by the ATLAS experiment at the LHC in 2015 and 2016. Decays of the τ-lepton pairs with at least one τ lepton decaying to final states with hadrons and a neutrino are considered. No significant excess above the expected background is observed in the data. The cross-section times branching ratio for nonresonant Higgs boson pair production is constrained to be less than 30.9 fb, 12.7 times the standard model expectation, at 95% confidence level. The data are also analyzed to probe resonant Higgs boson pair production, constraining a model with an extended Higgs sector based on two doublets and a Randall-Sundrum bulk graviton model. Upper limits are placed on the resonant Higgs boson pair production cross-section times branching ratio, excluding resonances X in the mass range 305 GeV
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| 35. |
- Aaboud, M, et al.
(författare)
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Search for top squarks decaying to tau sleptons in pp collisions at s =13 Te v with the ATLAS detector
- 2018
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Ingår i: Physical Review D. - 2470-0010. ; 98:3
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Tidskriftsartikel (refereegranskat)abstract
- A search for direct pair production of top squarks in final states with two tau leptons, b-jets, and missing transverse momentum is presented. The analysis is based on proton-proton collision data at s=13 TeV corresponding to an integrated luminosity of 36.1 fb-1 recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. Two exclusive channels with either two hadronically decaying tau leptons or one hadronically and one leptonically decaying tau lepton are considered. No significant deviation from the Standard Model predictions is observed in the data. The analysis results are interpreted in terms of model-independent limits and used to derive exclusion limits on the masses of the top squark t1 and the tau slepton τ1 in a simplified model of supersymmetry with a nearly massless gravitino. In this model, masses up to m(t1)=1.16 TeV and m(τ1)=1.00 TeV are excluded at 95% confidence level. © 2018 CERN.
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| 36. |
- Aaboud, M, et al.
(författare)
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Searches for exclusive Higgs and Z boson decays into J/ψ γ, ψ(2S) γ, and ϒ(nS) γ at s=13TeV with the ATLAS detector
- 2018
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 786, s. 134-155
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Tidskriftsartikel (refereegranskat)abstract
- Searches for the exclusive decays of the Higgs and Z bosons into a J/ψ, ψ(2S), or ϒ(nS) (n=1,2,3) meson and a photon are performed with a pp collision data sample corresponding to an integrated luminosity of 36.1fb−1 collected at s=13TeV with the ATLAS detector at the CERN Large Hadron Collider. No significant excess of events is observed above the expected backgrounds, and 95% confidence-level upper limits on the branching fractions of the Higgs boson decays to J/ψγ, ψ(2S)γ, and ϒ(nS)γ of 3.5×10−4, 2.0×10−3, and (4.9,5.9,5.7)×10−4, respectively, are obtained assuming Standard Model production. The corresponding 95% confidence-level upper limits for the branching fractions of the Z boson decays are 2.3×10−6, 4.5×10−6 and (2.8,1.7,4.8)×10−6, respectively. © 2018 The Author
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| 37. |
- Aad, G., et al.
(författare)
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ATLAS b-jet identification performance and efficiency measurement with tt¯ events in pp collisions at √s=13 TeV
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:11
-
Tidskriftsartikel (refereegranskat)abstract
- The algorithms used by the ATLAS Collaboration during Run 2 of the Large Hadron Collider to identify jets containing b-hadrons are presented. The performance of the algorithms is evaluated in the simulation and the efficiency with which these algorithms identify jets containing b-hadrons is measured in collision data. The measurement uses a likelihood-based method in a sample highly enriched in tt¯ events. The topology of the t→ Wb decays is exploited to simultaneously measure both the jet flavour composition of the sample and the efficiency in a transverse momentum range from 20 to 600 GeV. The efficiency measurement is subsequently compared with that predicted by the simulation. The data used in this measurement, corresponding to a total integrated luminosity of 80.5 fb - 1, were collected in proton–proton collisions during the years 2015–2017 at a centre-of-mass energy s= 13 TeV. By simultaneously extracting both the efficiency and jet flavour composition, this measurement significantly improves the precision compared to previous results, with uncertainties ranging from 1 to 8% depending on the jet transverse momentum.
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| 38. |
- Aad, G, et al.
(författare)
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ATLAS data quality operations and performance for 2015-2018 data-taking
- 2020
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Ingår i: Journal of Instrumentation. - : Institute of Physics Publishing (IOPP). - 1748-0221. ; 15:4
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS detector at the Large Hadron Collider reads out particle collision data from over 100 million electronic channels at a rate of approximately 100 kHz, with a recording rate for physics events of approximately 1 kHz. Before being certified for physics analysis at computer centres worldwide, the data must be scrutinised to ensure they are clean from any hardware or software related issues that may compromise their integrity. Prompt identification of these issues permits fast action to investigate, correct and potentially prevent future such problems that could render the data unusable. This is achieved through the monitoring of detector-level quantities and reconstructed collision event characteristics at key stages of the data processing chain. This paper presents the monitoring and assessment procedures in place at ATLAS during 2015-2018 data-taking. Through the continuous improvement of operational procedures, ATLAS achieved a high data quality efficiency, with 95.6% of the recorded proton-proton collision data collected at s=13 TeV certified for physics analysis.
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| 39. |
- Aad, G, et al.
(författare)
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Combination of searches for Higgs boson pairs in pp collisions at s=13TeV with the ATLAS detector
- 2020
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 800
-
Tidskriftsartikel (refereegranskat)abstract
- This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb−1 of proton–proton collision data at a centre-of-mass energy s=13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the bb¯bb¯, bb¯W+W−, bb¯τ+τ−, W+W−W+W−, bb¯γγ and W+W−γγ final states. Results are presented for non-resonant and resonant Higgs boson pair production modes. No statistically significant excess in data above the Standard Model predictions is found. The combined observed (expected) limit at 95% confidence level on the non-resonant Higgs boson pair production cross-section is 6.9 (10) times the predicted Standard Model cross-section. Limits are also set on the ratio (κλ) of the Higgs boson self-coupling to its Standard Model value. This ratio is constrained at 95% confidence level in observation (expectation) to −5.0
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| 40. |
- Aad, G, et al.
(författare)
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Combined measurements of Higgs boson production and decay using up to 80 fb-1 of proton-proton collision data at s =13 TeV collected with the ATLAS experiment
- 2020
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 1550-2368. ; 101:1
-
Tidskriftsartikel (refereegranskat)abstract
- Combined measurements of Higgs boson production cross sections and branching fractions are presented. The combination is based on the analyses of the Higgs boson decay modes H→γγ, ZZ∗, WW∗, ττ, bb, μμ, searches for decays into invisible final states, and on measurements of off-shell Higgs boson production. Up to 79.8 fb-1 of proton-proton collision data collected at s=13 TeV with the ATLAS detector are used. Results are presented for the gluon-gluon fusion and vector-boson fusion processes, and for associated production with vector bosons or top-quarks. The global signal strength is determined to be μ=1.11-0.08+0.09. The combined measurement yields an observed (expected) significance for the vector-boson fusion production process of 6.5σ (5.3σ). Measurements in kinematic regions defined within the simplified template cross section framework are also shown. The results are interpreted in terms of modifiers applied to the Standard Model couplings of the Higgs boson to other particles, and are used to set exclusion limits on parameters in two-Higgs-doublet models and in the simplified minimal supersymmetric Standard Model. No significant deviations from Standard Model predictions are observed. © 2020 CERN. © 2020 CERN, for the ATLAS Collaboration. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/" Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.
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| 41. |
- Aad, G, et al.
(författare)
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Evidence for the production of three massive vector bosons with the ATLAS detector
- 2019
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 798
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the production of three massive vector bosons in proton–proton collisions is performed using data at s=13 TeV recorded with the ATLAS detector at the Large Hadron Collider in the years 2015–2017, corresponding to an integrated luminosity of 79.8 fb−1. Events with two same-sign leptons ℓ (electrons or muons) and at least two reconstructed jets are selected to search for WWW→ℓνℓνqq. Events with three leptons without any same-flavour opposite-sign lepton pairs are used to search for WWW→ℓνℓνℓν, while events with three leptons and at least one same-flavour opposite-sign lepton pair and one or more reconstructed jets are used to search for WWZ→ℓνqqℓℓ. Finally, events with four leptons are analysed to search for WWZ→ℓνℓνℓℓ and WZZ→qqℓℓℓℓ. Evidence for the joint production of three massive vector bosons is observed with a significance of 4.1 standard deviations, where the expectation is 3.1 standard deviations. © 2019 The Author(s)
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| 42. |
- Aad, G, et al.
(författare)
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Identification of boosted Higgs bosons decaying into b-quark pairs with the ATLAS detector at 13 TeV
- 2019
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:10
-
Tidskriftsartikel (refereegranskat)abstract
- This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H→ bb¯ , for proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy s=13 TeV. These decays are reconstructed from calorimeter jets found with the anti-ktR= 1.0 jet algorithm. To tag Higgs bosons, a combination of requirements is used: b-tagging of R= 0.2 track-jets matched to the large-R calorimeter jet, and requirements on the jet mass and other jet substructure variables. The Higgs boson tagging efficiency and corresponding multijet and hadronic top-quark background rejections are evaluated using Monte Carlo simulation. Several benchmark tagging selections are defined for different signal efficiency targets. The modelling of the relevant input distributions used to tag Higgs bosons is studied in 36 fb- 1 of data collected in 2015 and 2016 using g→ bb¯ and Z(→ bb¯) γ event selections in data. Both processes are found to be well modelled within the statistical and systematic uncertainties. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 43. |
- Aad, G, et al.
(författare)
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Measurement of angular and momentum distributions of charged particles within and around jets in Pb+Pb and pp collisions at sNN =5.02 TeV with the ATLAS detector
- 2019
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Ingår i: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 100:6
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Tidskriftsartikel (refereegranskat)abstract
- Studies of the fragmentation of jets into charged particles in heavy-ion collisions can provide information about the mechanism of jet quenching by the hot and dense QCD matter created in such collisions, the quark-gluon plasma. This paper presents a measurement of the angular distribution of charged particles around the jet axis in sNN=5.02 TeV Pb+Pb and pp collisions, using the ATLAS detector at the LHC. The Pb+Pb and pp data sets have integrated luminosities of 0.49nb-1 and 25pb-1, respectively. The measurement is performed for jets reconstructed with the anti-kt algorithm with radius parameter R=0.4 and is extended to an angular distance of r=0.8 from the jet axis. Results are presented as a function of Pb+Pb collision centrality and distance from the jet axis for charged particles with transverse momenta in the 1- to 63-GeV range, matched to jets with transverse momenta in the 126- to 316-GeV range and an absolute value of jet rapidity of less than 1.7. Modifications to the measured distributions are quantified by taking a ratio to the measurements in pp collisions. Yields of charged particles with transverse momenta below 4 GeV are observed to be increasingly enhanced as a function of angular distance from the jet axis, reaching a maximum at r=0.6. Charged particles with transverse momenta above 4 GeV have an enhanced yield in Pb+Pb collisions in the jet core for angular distances up to r=0.05 from the jet axis, with a suppression at larger distances.
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| 44. |
- Aad, G, et al.
(författare)
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Measurement of Azimuthal Anisotropy of Muons from Charm and Bottom Hadrons in pp Collisions at s =13 TeV with the ATLAS Detector
- 2020
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Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 1079-7114 .- 0031-9007. ; 124:8
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Tidskriftsartikel (refereegranskat)abstract
- The elliptic flow of muons from the decay of charm and bottom hadrons is measured in pp collisions at √s=13 TeV using a data sample with an integrated luminosity of 150 pb-1 recorded by the ATLAS detector at the LHC. The muons from heavy-flavor decay are separated from light-hadron decay muons using momentum imbalance between the tracking and muon spectrometers. The heavy-flavor decay muons are further separated into those from charm decay and those from bottom decay using the distance-of-closest-approach to the collision vertex. The measurement is performed for muons in the transverse momentum range 4-7 GeV and pseudorapidity range |η| < 2.4. A significant nonzero elliptic anisotropy coefficient v2 is observed for muons from charm decays, while the v2 value for muons from bottom decays is consistent with zero within uncertainties.
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| 45. |
- Aad, G, et al.
(författare)
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Measurement of differential cross sections for single diffractive dissociation in √s = 8 TeV pp collisions using the ATLAS ALFA spectrometer
- 2020
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Ingår i: Journal of High Energy Physics. - : Springer Nature. - 1029-8479 .- 1126-6708. ; 2020:2
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Tidskriftsartikel (refereegranskat)abstract
- A dedicated sample of Large Hadron Collider proton-proton collision data at centre-of-mass energy s = 8 TeV is used to study inclusive single diffractive dissociation, pp → X p. The intact final-state proton is reconstructed in the ATLAS ALFA forward spectrometer, while charged particles from the dissociated system X are measured in the central detector components. The fiducial range of the measurement is −4.0 < log10ξ < −1.6 and 0.016 < |t| < 0.43 GeV2, where ξ is the proton fractional energy loss and t is the squared four-momentum transfer. The total cross section integrated across the fiducial range is 1.59 ± 0.13 mb. Cross sections are also measured differentially as functions of ξ, t, and ∆η, a variable that characterises the rapidity gap separating the proton and the system X. The data are consistent with an exponential t dependence, dσ/dt ∝ eBt with slope parameter B = 7.65 ± 0.34 GeV−2. Interpreted in the framework of triple Regge phenomenology, the ξ dependence leads to a pomeron intercept of α(0) = 1.07 ± 0.09. [Figure not available: see fulltext.] © 2020, The Author(s).
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| 46. |
- Aad, G, et al.
(författare)
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Measurement of distributions sensitive to the underlying event in inclusive Z boson production in pp collisions at √s = 13 TeV with the ATLAS detector
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:8
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents measurements of charged-particle distributions sensitive to the properties of the underlying event in events containing a Z boson decaying into a muon pair. The data were obtained using the ATLAS detector at the LHC in proton–proton collisions at a centre-of-mass energy of 13 Te with an integrated luminosity of 3.2fb-1. Distributions of the charged-particle multiplicity and of the charged-particle transverse momentum are measured in regions of the azimuth defined relative to the Z boson direction. The measured distributions are compared with the predictions of various Monte Carlo generators which implement different underyling event models. The Monte Carlo model predictions qualitatively describe the data well, but with some significant discrepancies. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 47. |
- Aad, G, et al.
(författare)
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Measurement of flow harmonics correlations with mean transverse momentum in lead–lead and proton–lead collisions at √sNN=5.02TeV with the ATLAS detector
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:12
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Tidskriftsartikel (refereegranskat)abstract
- To assess the properties of the quark–gluon plasma formed in ultrarelativistic ion collisions, the ATLAS experiment at the LHC measures a correlation between the mean transverse momentum and the flow harmonics. The analysis uses data samples of lead–lead and proton–lead collisions obtained at the centre-of-mass energy per nucleon pair of 5.02 TeV, corresponding to total integrated luminosities of 22μb-1 and 28nb-1, respectively. The measurement is performed using a modified Pearson correlation coefficient with the charged-particle tracks on an event-by-event basis. The modified Pearson correlation coefficients for the 2nd-, 3rd-, and 4th-order flow harmonics are measured in the lead–lead collisions as a function of event centrality quantified as the number of charged particles or the number of nucleons participating in the collision. The measurements are performed for several intervals of the charged-particle transverse momentum. The correlation coefficients for all studied harmonics exhibit a strong centrality evolution, which only weakly depends on the charged-particle momentum range. In the proton–lead collisions, the modified Pearson correlation coefficient measured for the 2nd-order flow harmonics shows only weak centrality dependence. The lead-lead data is qualitatively described by the predictions based on the hydrodynamical model.
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| 48. |
- Aad, G, et al.
(författare)
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Measurement of isolated-photon plus two-jet production in pp collisions at √s = 13 TeV with the ATLAS detector
- 2020
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Ingår i: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; 2020:3
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Tidskriftsartikel (refereegranskat)abstract
- The dynamics of isolated-photon plus two-jet production in pp collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset corresponding to an integrated luminosity of 36.1 fb−1. Cross sections are measured as functions of a variety of observables, including angular correlations and invariant masses of the objects in the final state, γ + jet + jet. Measurements are also performed in phase-space regions enriched in each of the two underlying physical mechanisms, namely direct and fragmentation processes. The measurements cover the range of photon (jet) transverse momenta from 150 GeV (100 GeV) to 2 TeV. The tree-level plus parton-shower predictions from Sherpa and Pythia as well as the next-to-leading-order QCD predictions from Sherpa are compared with the measurements. The next-to-leading-order QCD predictions describe the data adequately in shape and normalisation except for regions of phase space such as those with high values of the invariant mass or rapidity separation of the two jets, where the predictions overestimate the data. [Figure not available: see fulltext.] © 2020, The Author(s).
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| 49. |
- Aad, G, et al.
(författare)
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Measurement of KS0 and Λ production in tt¯ dileptonic events in pp collisions at √s= 7 TeV with the ATLAS detector
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:12
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of KS0 and Λ production in tt¯ final states have been performed. They are based on a data sample with integrated luminosity of 4.6 fb - 1 from proton–proton collisions at a centre-of-mass energy of 7 TeV, collected in 2011 with the ATLAS detector at the Large Hadron Collider. Neutral strange particles are separated into three classes, depending on whether they are contained in a jet, with or without a b-tag, or not associated with a selected jet. The aim is to look for differences in their main kinematic distributions. A comparison of data with several Monte Carlo simulations using different hadronisation and fragmentation schemes, colour reconnection models and different tunes for the underlying event has been made. The production of neutral strange particles in tt¯ dileptonic events is found to be well described by current Monte Carlo models for KS0 and Λ production within jets, but not for those produced outside jets. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 50. |
- Aad, G, et al.
(författare)
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Measurement of single top-quark production in association with a W boson in the single-lepton channel at √s=8TeV with the ATLAS detector
- 2021
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:8
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Tidskriftsartikel (refereegranskat)abstract
- The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at s√=8TeV. The dataset corresponds to an integrated luminosity of 20.2fb−1, and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant tt¯ background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured cross-section is σtW=26±7pb, in good agreement with the Standard Model expectation.
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