SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Hansson Kurt) "

Sökning: WFRF:(Hansson Kurt)

  • Resultat 1-31 av 31
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Charpentier Ljungqvist, Fredrik, 1982-, et al. (författare)
  • Regional Patterns of Late Medieval and Early Modern European Building Activity Revealed by Felling Dates
  • 2022
  • Ingår i: Frontiers in Ecology and Evolution. - : Frontiers Media SA. - 2296-701X. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Although variations in building activity are a useful indicator of societal well-being and demographic development, historical datasets for larger regions and longer periods are still rare. Here, we present 54,045 annually precise dendrochronological felling dates from historical construction timber from across most of Europe between 1250 and 1699 CE to infer variations in building activity. We use geostatistical techniques to compare spatiotemporal dynamics in past European building activity against independent demographic, economic, social and climatic data. We show that the felling dates capture major geographical patterns of demographic trends, especially in regions with dense data coverage. A particularly strong negative association is found between grain prices and the number of felling dates. In addition, a significant positive association is found between the number of felling dates and mining activity. These strong associations, with well-known macro-economic indicators from pre-industrial Europe, corroborate the use of felling dates as an independent source for exploring large-scale fluctuations of societal well-being and demographic development. Three prominent examples are the building boom in the Hanseatic League region of northeastern Germany during the 13th century, the onset of the Late Medieval Crisis in much of Europec. 1300, and the cessation of building activity in large parts of central Europe during armed conflicts such as the Thirty Years’ War (1618–1648 CE). Despite new insights gained from our European-wide felling date inventory, further studies are needed to investigate changes in construction activity of high versus low status buildings, and of urban versus rural buildings, and to compare those results with a variety of historical documentary sources and natural proxy archives.
  •  
3.
  • Cui, Xiaotong, et al. (författare)
  • The impact of time-updated resting heart rate on cause-specific mortality in a random middle-aged male population : a lifetime follow-up
  • 2021
  • Ingår i: Clinical Research in Cardiology. - : Springer Nature. - 1861-0684 .- 1861-0692. ; 110:6, s. 822-830
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundA high resting heart rate (RHR) is associated with an increase in adverse events. However, the long-term prognostic value in a general population is unclear. We aimed to investigate the impact of RHR, based on both baseline and time-updated values, on mortality in a middle-aged male cohort.MethodsA random population sample of 852 men, all born in 1913, was followed from age 50 until age 98, with repeated examinations including RHR over a period of 48 years. The impact of baseline and time-updated RHR on cause-specific mortality was assessed using Cox proportional hazard models and cubic spline models.ResultsA baseline RHR of ≥ 90 beats per minute (bpm) was associated with higher all-cause mortality, as compared with an RHR of 60–70 bpm (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.17–2.19, P = 0.003), but not with cardiovascular (CV) mortality. A time-updated RHR of < 60 bpm (HR 1.41, 95% CI 1.07–1.85, P = 0.014) and a time-updated RHR of 70–80 bpm (HR 1.34, 95% CI 1.02–1.75, P = 0.036) were both associated with higher CV mortality as compared with an RHR of 60–70 bpm after multivariable adjustment. Analyses using cubic spline models confirmed that the association of time-updated RHR with all-cause and CV mortality complied with a U-shaped curve with 60 bpm as a reference.ConclusionIn this middle-aged male cohort, a time-updated RHR of 60–70 bpm was associated with the lowest CV mortality, suggesting that a time-updated RHR could be a useful long-term prognostic index in the general population.
  •  
4.
  • Ergatoudes, Constantinos, et al. (författare)
  • Comparison of incidence rates and risk factors of heart failure between two male cohorts born 30 years apart
  • 2020
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X.
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To compare two cohorts of middle-aged men from the general population born 30 years apart for incidence and predictors of heart failure (HF). Methods: Two population samples of men, born in 1913 (n=855) and in 1943 (n=797), were examined at 50 years of age and followed up for 21 years (1963-1994 and 1993-2014). Cox regression analysis was used to examine the impact of different factors on the risk of developing HF. Results: Eighty men born in 1913 (9.4%) and 42 men born in 1943 (5.3%) developed HF during follow-up; adjusted HRs comparing the two cohorts (born 1943 vs 1913) were: 0.46 (95% CI 0.28 to 0.74, p=0.002). In both cohorts, higher body mass index, higher diastolic blood pressure, treatment for hypertension, onset of either atrial fibrillation (AF), ischaemic heart disease and diabetes mellitus were associated with higher risk of HF. Higher heart rate was associated with an increased risk only in men born in 1913, whereas higher systolic blood pressure (SBP), smoking, higher glucose, higher cholesterol and physical inactivity were associated with an increased risk in men born in 1943. AF contributed higher risk of incident HF, whereas SBP and physical inactivity contributed lower risk in men born in 1943 compared with men born in 1913. Conclusions: Men born in 1943 had half the risk of HF after their 50s than those born 30 years earlier. AF, obesity, ischaemic heart disease, diabetes and hypertension remain important precursors of HF. © 2020 Author(s).
  •  
5.
  •  
6.
  • Fridolin, Ivo, 1971-, et al. (författare)
  • Optical non-invasive technique for vessel imaging : II. A simplified photon diffusion analysis
  • 2000
  • Ingår i: Physics in Medicine and Biology. - : Institute of Physics (IOP). - 0031-9155 .- 1361-6560. ; 45:12, s. 3779-3792
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this paper is to explain theoretically the origin of previously presented experimental results by an optical non-invasive method using NIR for imaging blood vessels based on a specific combination of several physical parameters. The theoretical model is based on the diffusion approximation derived from the transport theory deep in a bulk tissue. An analytical solution was obtained describing photon behaviour under certain conditions during vessel identification. The modelled results indicate that the vessel identification facility depends upon source-detector separation and vessel depth, and does not depend essentially on the radiant power from the light source. The solution offers a relatively simple theoretical explanation of the experimental results and can be applied to several other clinical applications using similar technical solutions.
  •  
7.
  • Fu, Michael, et al. (författare)
  • Although Coronary Mortality Has Decreased, Rates of Cardiovascular Disease Remain High : 21 Years of Follow-Up Comparing Cohorts of Men Born in 1913 With Men Born in 1943
  • 2018
  • Ingår i: Journal of the American Heart Association. - : WILEY. - 2047-9980. ; 7:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Background - Despite a decline in mortality rates from cardiovascular disease (CVD) in the past few decades, the burden of CVD in a contemporary population remains inadequately addressed. Therefore, this study was aimed to investigate secular trends in mortality from coronary artery disease and all-cause mortality over 2 decades, by comparing 2 cohorts of men born 30 years apart and evaluate the prediction of the risk of CVD and all-cause death in a contemporary random sample of Swedish men.Methods and Results - Two cohorts of randomly selected men born in 1913 (855 men) and 1943 (798 men) were first examined at age 50 in 1963 and 1993, respectively, and followed longitudinally over 21 years. All-cause mortality and coronary artery disease death were lower in 50-to 71-year-old men born in 1943 compared with those born in 1913, with unadjusted hazard ratios of 0.57 (0.45-0.71) and 0.34 (0.22-0.53), respectively. After adjustment for risk factors (smoking, serum cholesterol, hypertension, systolic blood pressure, diabetes mellitus, body mass index, and physical activity), the differences between the cohorts remained significant for coronary artery disease, hazard ratios 0.57 (0.34-0.94), P=0.029, but not for all-cause mortality hazard ratios 0.82 (0.62-1.07), P=0.14. However, the rate of CVD events during follow-up was still high (30.7%) for the men born in 1943. No statistically significant interaction by birth cohort in contribution of risk factors to death was found between 2 cohorts except physical inactivity.Conclusions - Despite a marked reduction in the rate of coronary artery disease death over the past 30 years, the burden of CVD events and all-cause mortality remains high. Therefore, intensified efforts to modify contributing risk factors are still required.
  •  
8.
  • Giang, Kok Wai, 1984, et al. (författare)
  • Long-term risk of stroke and myocardial infarction in middle-aged men with a hypertensive response to exercise : a 44-year follow-up study
  • 2021
  • Ingår i: Journal of Hypertension. - : Wolters Kluwer. - 0263-6352 .- 1473-5598. ; 39:3, s. 503-510
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Data on the prognostic value of hypertensive response to exercise in cardiovascular disease are limited. The aim was to determine whether SBP reactions during exercise have any prognostic value in relation to the long-term risk of stroke and myocardial infarction (MI).Patients and methods: A representative cohort of men from Gothenburg, Sweden, born in 1913, who performed a maximum exercise test at age 54 years, (n = 604), was followed-up for a maximum of 44 years with regard to stroke and MI. Results: Among the 604 men, the mean resting and maximum SBP was 141.5 (SD 18.8) and 212.1 (SD 24.6) mmHg, respectively. For maximum SBP, the risk of stroke increased by 34% (hazard ratio 1.34, 95% confidence interval 1.11-1.61) per 1-SD increase, while no risk increase was observed for MI. The highest risk of stroke among blood pressure groups was observed among men with a resting SBP of at least 140 mmHg and a maximum SBP of at least 210 mmHg with an hazard ratio of 2.09 (95% confidence interval 1.29-3.40), compared with men with a resting SBP of less than 140 mmHg and a maximum SBP of less than 210 mmHg, independent of smoking, blood glucose, cholesterol and BMI.Conclusion: Among middle-aged men with high resting and maximum blood pressure during maximum exercise workload, an increased risk of stroke was observed but not for MI. Further studies with larger sample sizes are needed to investigate the underlying mechanisms of the increased risk of stroke among individuals with hypertensive response to exercise.
  •  
9.
  • Hansson, Klas, 1972- (författare)
  • Water and Heat Transport in Road Structures : Development of Mechanistic Models
  • 2005
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The coupled transport of water and heat, involving freezing and thawing, in the road structure and its immediate environment is important to consider for optimal design and maintenance of roads and when assessing solute transport, of e.g. de-icing salt, from roads. The objective of this study was to develop mechanistic models, and measurement techniques, suitable to describe and understand water flow and heat flux in road structures exposed to a cold climate. Freezing and thawing was accounted for by implementing new routines in two numerical models (HYDRUS1D/2D). The sensitivity of the model output to changes in parameter values and operational hydrological data was investigated by uncertainty and sensitivity analyses. The effect of rainfall event characteristics and asphalt fractures on the subsurface flow pattern was investigated by scenario modelling. The performance of water content reflectometers (WCR), measuring water content, was evaluated using measurements in two road structure materials. A numerical model was used to simulate WCR sensor response. The freezing/thawing routines were stable and provided results in agreement with laboratory measurements. Frost depth, thawing period, and freezing-induced water redistribution in a model road was greatly affected by groundwater level and type of subgrade. The simulated subsurface flow patterns corresponded well with published field observations. A new method was successful in enabling the application of time domain reflectometer (TDR) calibration equations to WCR output. The observed distortion in sampling volume for one of the road materials could be explained by the WCR sensor numerical model. Soil physical, hydrological, and hydraulic modules proved successful in simulating the coupled transport of water and heat in and on the road structure. It was demonstrated in this thesis that numerical models can improve the interpretation and explanation of measurements. The HYDRUS model was an accurate and pedagogical tool, clearly useful in road design and management.
  •  
10.
  • Hylander, Lars Daniel, 1954-, et al. (författare)
  • Climate saving soils with biochar.
  • 2010
  • Ingår i: NJF seminar 430, Climate Change and Agricultural Production in the Baltic Sea Region, 4-6 May 2010 Sweden.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Soil organic matter has a fundamental importance for soil fertility. Increased mineralization due to global warming and increased harvesting of crop residues such as straw for energy recovery will reduce soil organic matter. Thereby future harvests may decrease. Biochar may mitigate this and has in tropical soils demonstrated increased soil fertility lasting for thousands of years in the form of Terra Preta, which was produced by Indians in the Amazon before contacts with the Western culture. The Western scientific community was until recently not aware about biochar, although practitioners sporadically employed it as a soil conditiner in historic times.Biochar is a charcoal-like material produced by heating organinc matgerials to several hundred degrees at limited oxygene supply, so called pyrolysis. It has a large specific surface, ranging from a few to several hundred square meters per gram char, depending of raw material, temperature, time and water content. Its large porosity makes it capable of holding large volumes of plant available water, nutrients and soil microbes. Mixed into soil, biochar is persistent to further degradation with a half life typically around 5000 years.The potential of adding biochar to soil is threefold: I.) it mitigates high air CO2 levels by being a reliable carbon sink; II.) it improves soil fertility by increasing plant available water, nutrients, and soil microbes as well as improving soil structure; III.) it reduces nutrient leakage and losses to ground and surface waters. In addition, production of biochar delivers energy at the processing unit and other raw materials possible to use in the synthetic industry. Burning bioenergy for heating purposes can maintain the present CO2 level, but it cannot reduce air CO2 levels, as biochar production can. It should be observed that biochar, once spread into soil, cannot be recovered and its content of CO2 cannot intentionally be released as is the case if logging forests, initially intended to be a carbon sink. Similarly, Carbon dioxide Cap and Storage (CCS), presently being developed at certain fossil fuel fired power and heat generation plants, cannot reduce the actual CO2 content in the atmosphere. In addition, these techniques are costly and demands tchnically advanced units at large scale.To sum up, biochar production and application to agricultural soils may create a triple wins scenario, where farmers get higher yields and compensation for environmental services; the society gets reduced eutrofication and less negative environmental impacts from intense farming practices; and humanity gets sustainable food production at the same time as climate change effects and the connected risk of reaching climate tipping points are reduced. Biochar contributes to a sustainable society in its true meaning for future generations by closing the cycles between arable land and human habitations. The technique is democratic, since it can be applied anywhere around the globe where plants are growing and it is not dependent of economic, technical or infrastructural development. It is independent of scale, too, so also home gardeners may transform garden waste into a soil improver to use in their own garden.
  •  
11.
  • Hylander, Lars Daniel, 1954-, et al. (författare)
  • Phosphorus recycling at a household-size wastewater facility at Norrbäck farm.
  • 2008
  • Ingår i: Phosphorus management in Nordic-Baltic agriculture - reconciling productivity and environmental protection.. ; , s. 130-135
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Wastewater has the potential to interfere with the Swedish Environmental quality objectives, such as a Non-Toxic Environment, Zero Eutrophication, Flourishing Lakes and Streams, Good-Quality Groundwater, A Balanced Marine Environment, Thriving Wetlands, a Good Built Environment, and a Rich Diversity of Plant and Animal Life (Swedish Environmental Objectives Council, 2008). A general introduction of the evaluated concept for wastewater treatment in the country side would make away with rural household wastewater as a potential threat to these objectives. In addition, such an approach would fulfil the goal of recycling P as a nutrient in crop production (Naturvårdsverket, 2004).
  •  
12.
  •  
13.
  • Ladenvall, Per, 1972, et al. (författare)
  • Low aerobic capacity in middle-aged men associated with increased mortality rates during 45 years of follow-up
  • 2016
  • Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 23:14, s. 1557-1564
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Low aerobic capacity has been associated with increased mortality in short-term studies. The aim of this study was to evaluate the predictive power of aerobic capacity for mortality in middle-aged men during 45-years of follow-up. Design The study design was a population-based prospective cohort study. Methods A representative sample from Gothenburg of men born in 1913 was followed from 50-99 years of age, with periodic medical examinations and data from the National Hospital Discharge and Cause of Death registers. At 54 years of age, 792 men performed an ergometer exercise test, with 656 (83%) performing the maximum exercise test. Results In Cox regression analysis, low predicted peak oxygen uptake (VO2max), smoking, high serum cholesterol and high mean arterial blood pressure at rest were significantly associated with mortality. In multivariable analysis, an association was found between predicted VO2max tertiles and mortality, independent of established risk factors. Hazard ratios were 0.79 (95% confidence interval (CI) 0.71-0.89; p<0.0001) for predicted VO2max, 1.01 (1.002-1.02; p<0.01) for mean arterial blood pressure, 1.13 (1.04-1.22; p<0.005) for cholesterol, and 1.58 (1.34-1.85; p<0.0001) for smoking. The variable impact (Wald's (2)) of predicted VO2max tertiles (15.3) on mortality was secondary only to smoking (31.4). The risk associated with low predicted VO2max was evident throughout four decades of follow-up. Conclusion In this representative population sample of middle-aged men, low aerobic capacity was associated with increased mortality rates, independent of traditional risk factors, including smoking, blood pressure and serum cholesterol, during more than 40 years of follow-up.
  •  
14.
  • Londo, Marc, et al. (författare)
  • Eyes on the track, mind on the horizon: The REFUEL EU Road Map for biofuels
  • 2008
  • Ingår i: Proceedings of the 16th European Biomass Conference & Exhibition - From research to industry and markets, Feria Valencia, Spain, 2-6 June 2008.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The current hot debate on biofuels calls for a balanced and realistic long-term strategy for biofuels. The REFUEL project provides several ingredients for such a strategy. Analyses in this project indicate that domestically produced biofuels can cover a significant share of EU fuel demand in the coming decades, with the EU-12 new member states and Ukraine as most promising regions. This potential can be realised with residual streams and on existing agricultural land, without conversion of e.g. nature reserves. Second-generation biofuels are essential for the long-term success of biofuels due to their superior performance in many ways. But generally, the key challenge for the near future would be how to enhance the development of biofuels in a responsible way, i.e. stimulating the production chains with the best performance, and preventing negative impacts e.g., by paying careful attention to possible system impacts of biofuel production such as indirect land use changes and rising food prices. Finally, 2nd generation biofuels require specific policy: the precursor role of 1st generation is overrated, both in technical terms as well as in their role as market precursors. When it comes to synergies, 2nd generation biofuels might benefit more from other developments in the energy sector, such as initiatives in co-firing of biomass for (heat and) power, than from 1st generation biofuels, also because of the public resistance that the latter induce.
  •  
15.
  • Londo, Marc, et al. (författare)
  • REFUEL: an EU road map for biofuels
  • 2007
  • Ingår i: Proceedings of the Risø International Energy Conference 2007, 22-24 May.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • A successful mid-term development of biofuels calls for a robust road map. REFUEL assesses inter alia least-cost biofuel chain options, their benefits, outlines the technological, legislative and other developments that should take place, and evaluate different policy strategies for realisation. Some preliminary conclusions of the project are discussed here. There is a significant domestic land potential for energy crops in the EU, which could supply between one quarter and one third of gasoline and diesel demand by 2030 if converted into advanced biofuels. A biomass supply of 8 to 10 EJ of primary energy could be available at costs around or below 3 €/GJ. However, the introduction of advanced biofuel options may meet a considerable introductory cost barrier, which will not be overcome when EU policy is oriented to the introduction of biofuels at least cost. Therefore, conventional biodiesel en ethanol may dominate the market for decades to come, unless biofuels incentives are differentiated, e.g. on the basis of the differences in greenhouse gas performance among biofuels.The introduction of advanced biofuels may also be enhanced by creating stepping stones or searching introduction synergies. A stepping stone can be the short-term development of lignocellulosic biomass supply chains for power generation by co-firing; synergies can be found between advanced FT-diesel production and hydrogen production for the fuel cell.
  •  
16.
  • Londo, Marc, et al. (författare)
  • The REFUEL EU road map for biofuels in transport: Application of the project’s tools to some short-term policy issues
  • 2010
  • Ingår i: Biomass and Bioenergy. - : Elsevier BV. - 1873-2909 .- 0961-9534. ; 34:2, s. 244-250
  • Tidskriftsartikel (refereegranskat)abstract
    • The current hot debate on biofuels calls for a balanced and realistic long-term strategy forbiofuels. The REFUEL project provides several ingredients for such a strategy. Analyses inthis project indicate that domestically produced biofuels can cover a significant share of EUfuel demand in the coming decades, with the EU-12 new member states and Ukraine asmost promising regions. This potential can be realised with residual streams and onexisting agricultural land, without conversion of e.g. nature reserves. Second generationbiofuels are essential for the long-term success of biofuels due to their superior performancein many ways. But generally, the key challenge for the near future would be how toenhance the development of biofuels in a responsible way, i.e. stimulating the productionchains with the best performance, and preventing negative impacts e.g., by paying carefulattention to possible system impacts of biofuel production such as indirect land usechanges and rising food prices. Finally, 2nd generation biofuels require specific policy: theprecursor role of 1st generation is overrated, both in technical terms as well as in their roleas market precursors. When it comes to synergies, 2nd generation biofuels might benefitmore from other developments in the energy sector, such as initiatives in co-firing ofbiomass for (heat and) power, than from 1st generation biofuels, also because of the publicresistance that the latter induce.
  •  
17.
  •  
18.
  •  
19.
  • Mandalenakis, Zacharias, 1979, et al. (författare)
  • Atrial natriuretic peptide as a predictor of atrial fibrillation in a male population study. The Study of Men Born in 1913 and 1923
  • 2014
  • Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 171:1, s. 44-48
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Atrial fibrillation is one of the most common arrhythmias in clinical practice and it is often diagnosed after a complication occurs. The study aimed to evaluate the predictive value of atrial natriuretic peptide (ANP) for atrial fibrillation in a male population-based study. Methods and results: This study is a part of the "Study of Men Born in 1913 and 1923", a longitudinal prospective cohort study of men, living in the city of Gothenburg in Sweden. A population-based sample of 528 men was investigated in 1988 when they were aged 65 years (n = 134) and 75 years (n = 394), and they were followed up for 16 years. Blood samples were collected from all 528 men at baseline and plasma ANP levels were analyzed by radioimmunoassay. Hazard ratios were estimated by competing-risk regression analysis. One hundred five participants were excluded because of a prior diagnosis of atrial fibrillation, congestive heart failure, severe hypertension, or severe chronic renal insufficiency. Of the remaining 423 participants, 90 men were diagnosed with atrial fibrillation over the 16-year follow-up. In multivariable analysis, men in the two highest quartiles of ANP levels had a significantly higher risk for atrial fibrillation compared with men in the lowest ANP quartile. The adjusted ratio was 3.14 (95% CI 1.59-6.20) for the third ANP quartile and 3.36 (95% CI 1.72-6.54) for the highest quartile of ANP level. Conclusions: In this population-based longitudinal study, we found that elevated ANP levels at baseline predicted atrial fibrillation during a follow-up time of 16 years. 
  •  
20.
  • Persson, Carina Ulla, 1970, et al. (författare)
  • Determinants of Stroke in a General Male Population : Forty-Eight Year Time-Dependent Updated Follow-Up of the Study of Men Born in 1913
  • 2018
  • Ingår i: Stroke. - : LIPPINCOTT WILLIAMS & WILKINS. - 0039-2499 .- 1524-4628. ; 49:12, s. 2830-2836
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and Purpose - To further improve preventive strategies against stroke, there is a need for epidemiological long-term studies. The study aimed at a prospective investigation of stroke determinants in the general male population.Methods - During a period of 48 years, from 50 to 98 years of age, a population-based sample of 854 men was followed using repeated medical examinations, lifestyle questionnaires, data from hospital records and the National Cause of Death Register.Results - Determinants of ischemic stroke were atrial fibrillation (hazard ratio [HR], 6.61; 95% CI, 4.47-9.77); mother dead from cardiovascular disease (HR, 1.53; 1.09-2.17); high education (HR, 0.81; 0.69-0.96); and high physical activity level during leisure time (HR, 0.68; 0.50-0.93). For hemorrhagic stroke heart rate (HR, 1.04; 1.01-1.06) and mother dead from stroke (HR, 3.56; 1.43-8.87) constituted an increased risk. Statistically significant determinants for all stroke were atrial fibrillation (HR, 5.34; 3.68-7.75); high diastolic blood pressure (HR, 1.02; 1.01-1.03); high body weight (HR, 0.96; 0.94-0.99); high educational level (HR, 0.79; 0.68-0.92); wide waist circumference (HR, 1.04; 1.01-1.07); smoking (HR, 1.25; 1.06-1.48); mother dead from cerebrovascular disease (HR, 1.43; 1.05-1.94); and diabetes mellitus (HR, 1.65; 1.02-2.68). Of all men diagnosed with atrial fibrillation, 88% had a stroke during follow-up.Conclusions - Atrial fibrillation was by far the strongest determinant of stroke during 48 years of follow-up in a male population sample followed until the age of 98 years. The results warrant improved prophylaxis through intense treatment of modifiable determinants.
  •  
21.
  • Rosengren, Annika, 1951, et al. (författare)
  • Obesity and trends in cardiovascular risk factors over 40 years in Swedish men aged 50.
  • 2009
  • Ingår i: Journal of internal medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 266:3, s. 268-76
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To study trends over 40 years in cardiovascular risk factors in normal weight, overweight and obese men, all aged 50 when examined. Design. Cross-sectional studies of five successive cohorts of men aged 50. SETTING: City of Göteborg, Sweden. SUBJECTS: Random population samples of altogether 3251 urban Swedish men born in 1913, 1923, 1933, 1943 and 1953. MAIN OUTCOME MEASURES: Anthropometry, cardiovascular risk factors, rates of nonsmoking, normotension and serum cholesterol <5 mmol L(-1) over four decades. RESULTS: Over 40 years, there was a net increase in body mass index (BMI) from 24.8 (SD = 3.2) to 26.4 (3.7) kg m(-2) (P < 0.0001), with an increase in the prevalence of obesity (BMI >or= 30 kg m(-2)) from 6.0% in 1963 to 13.8% in 2003. Favourable trends with respect to smoking, blood pressure and serum cholesterol were observed similarly amongst normal weight, overweight and obese men. In 1963, 24% of obese men were normotensive compared to 45% in 2003, and 6% had serum cholesterol <5 mmol L(-1) compared to 34% in 2003. Compared with obese men in 1963, men who were obese in 2003 had an odds ratio (OR) of 3.39 being a nonsmoker [95% confidence interval (CI): 1.56 to 7.36], 2.67 of being normotensive (1.23 to 5.83) and having serum cholesterol <5 mmol L(-1) of 8.30 (2.37 to 29.0). However, optimal risk factor status - no smoking, normotension and total serum cholesterol <5 mmol L(-1)- was still present in less than one in six men in 2003, similar across BMI categories. CONCLUSIONS: Obese Swedish men who are now in their fifties have much lower levels of other risk factors compared with obese men 40 years ago. This could contribute to explain why coronary heart disease death rates still are falling despite increasing rates of obesity.
  •  
22.
  • Rusek, Linnéa, et al. (författare)
  • Lifetime risk of stroke in the general male population
  • 2020
  • Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 142:1, s. 30-36
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives Most previous studies of incidence rates of stroke are from register studies, while data from prospective cohort studies are limited. The aim of the present study was to describe hazard rates, prevalence and cumulative proportion free from stroke during a lifelong follow-up of a representative sample of middle-aged men sampled from the general population. Methods A population-based sample of 855 men, all born in 1913, was investigated at 50 years of age and followed up with repeated medical examinations at age 54, 60, 67, 75 and 80. Data from hospital records and the Cause of Death Register were collected, and all stroke events during 48 years of follow-up were registered. Medical records were scrutinized in order to confirm and validate the stroke diagnoses. Results One man was excluded because of stroke prior to baseline, while 176 of the remaining 854 men (20.7%) suffered a first-ever stroke during follow-up. The total 5-year stroke risk (hazard rate) increased with age, from 3.54 (95% CI: 0-7.55) per 1000 persons at risk at age 50 years, to 119.05 (95% CI: 45.39-192.70) at age 90 years. The stroke prevalence peaked at age 80 and older, with about 120 cases per 1000 years of observation. The survival rate (cumulative proportion free from stroke) at age 98 was 50.0%. Conclusion One out of five men in this population sample suffered a stroke of any type during follow-up from 50 to 98 years of age and the cumulative incidence was close to 50%.
  •  
23.
  • Sakalaki, Maria, 1986, et al. (författare)
  • Cumulative incidence and risk factors of myocardial infarction during 20years of follow-up: comparing two cohorts of middle-aged men born 30years apart
  • 2023
  • Ingår i: Clinical Research in Cardiology. - 1861-0684 .- 1861-0692.
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To study cumulative incidence and predictors of myocardial infarction (MI) in two random general population samples consisting of middle-aged Swedish men born 30years apart. Method: Results from the “Study of Men Born In 1913” and the “Study of Men Born In 1943”, two longitudinal cohort studies performed in the same geographic area and using the same methodology were compared. Both cohorts were followed prospectively from 50 to 70years of age. MI was defined as first myocardial infarction, fatal or non-fatal. Results: Men born in 1943 had a 34% lower cumulative risk of first MI [HR 0.66 (0.50–0.88), p = 0.0051] during follow-up as compared to men born in 1913. Interaction analysis showed that hypertension had a significantly higher impact on risk of MI in cohort 1943 than in cohort 1913 [HR 2.33 (95% CI 1.41–3.83)] and [HR 1.10 (0.74–1.62)], p = 0.0009 respectively. The population attributable risk for hypertension was 2.5-fold higher in the cohort of men born in 1943 as compared to men born in 1913, and diabetes mellitus and sedentary lifestyle attributed more to MI risk in cohort 1943 than in cohort 1913. On the contrary, smoking and total cholesterol have less attributable risk to MI in cohort 1943 than in cohort 1913. Conclusion: Despite declining incident MI and improved cardiovascular prevention in general, hypertension remains an increasingly important attributable risk factor to MI together with diabetes mellitus and sedentary lifestyle over time.
  •  
24.
  • Spencer, Rebecca, et al. (författare)
  • EVERREST prospective study : A 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction
  • 2017
  • Ingår i: BMC Pregnancy and Childbirth. - : Springer Science and Business Media LLC. - 1471-2393. ; 17:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and conduct of the EVERREST Clinical Trial: a phase I/IIa trial to assess the safety and efficacy of maternal vascular endothelial growth factor (VEGF) gene therapy in severe early onset FGR. Data and samples from the EVERREST Prospective Study will be used to identify ultrasound and/or biochemical markers of prognosis in pregnancies with an estimated fetal weight (EFW) <3rd centile between 20+0 and 26+6 weeks of gestation. Methods: This is a 6 year European multicentre prospective cohort study, recruiting women with a singleton pregnancy where the EFW is <3rd centile for gestational age and <600 g at 20+0 to 26+6 weeks of gestation. Detailed data are collected on: maternal history; antenatal, peripartum, and postnatal maternal complications; health economic impact; psychological impact; neonatal condition, progress and complications; and infant growth and neurodevelopment to 2 years of corrected age in surviving infants. Standardised longitudinal ultrasound measurements are performed, including: fetal biometry; uterine artery, umbilical artery, middle cerebral artery, and ductus venosus Doppler velocimetry; and uterine artery and umbilical vein volume blood flow. Samples of maternal blood and urine, amniotic fluid (if amniocentesis performed), placenta, umbilical cord blood, and placental bed (if caesarean delivery performed) are collected for bio-banking. An initial analysis of maternal blood samples at enrolment is planned to identify biochemical markers that are predictors for fetal or neonatal death. Discussion: The findings of the EVERREST Prospective Study will support the development of a novel therapy for severe early onset FGR by describing in detail the natural history of the disease and by identifying women whose pregnancies have the poorest outcomes, in whom a therapy might be most advantageous. The findings will also enable better counselling of couples with affected pregnancies, and provide a valuable resource for future research into the causes of FGR. Trial registration:NCT02097667registered 31st October 2013.
  •  
25.
  • Spencer, Rebecca, et al. (författare)
  • Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction
  • 2023
  • Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 133:18
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND. Severe, early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, thus preventing accurate patient counseling. We investigated the use of maternal serum protein and ultrasound measurements at diagnosis to predict fetal or neonatal death and 3 secondary outcomes: fetal death or delivery at or before 28+0 weeks, development of abnormal umbilical artery (UmA) Doppler velocimetry, and slow fetal growth. METHODS. Women with singleton pregnancies (n = 142, estimated fetal weights [EFWs] below the third centile, less than 600 g, 20+0 to 26+6 weeks of gestation, no known chromosomal, genetic, or major structural abnormalities) were recruited from 4 European centers. Maternal serum from the discovery set (n = 63) was analyzed for 7 proteins linked to angiogenesis, 90 additional proteins associated with cardiovascular disease, and 5 proteins identified through pooled liquid chromatography and tandem mass spectrometry. Patient and clinician stakeholder priorities were used to select models tested in the validation set (n = 60), with final models calculated from combined data. RESULTS. The most discriminative model for fetal or neonatal death included the EFW z score (Hadlock 3 formula/Marsal chart), gestational age, and UmA Doppler category (AUC, 0.91; 95% CI, 0.86-0.97) but was less well calibrated than the model containing only the EFW z score (Hadlock 3/Marsal). The most discriminative model for fetal death or delivery at or before 28+0 weeks included maternal serum placental growth factor (PlGF) concentration and UmA Doppler category (AUC, 0.89; 95% CI, 0.83-0.94). CONCLUSION. Ultrasound measurements and maternal serum PlGF concentration at diagnosis of severe, early-onset FGR predicted pregnancy outcomes of importance to patients and clinicians.
  •  
26.
  • Thompson, Rachel, et al. (författare)
  • RD-Connect : An Integrated Platform Connecting Databases, Registries, Biobanks and Clinical Bioinformatics for Rare Disease Research
  • 2014
  • Ingår i: Journal of general internal medicine. - : Springer Science and Business Media LLC. - 0884-8734 .- 1525-1497. ; 29:S3, s. S780-S787
  • Forskningsöversikt (refereegranskat)abstract
    • Research into rare diseases is typically fragmented by data type and disease. Individual efforts often have poor interoperability and do not systematically connect data across clinical phenotype, genomic data, biomaterial availability, and research/trial data sets. Such data must be linked at both an individual-patient and whole-cohort level to enable researchers to gain a complete view of their disease and patient population of interest. Data access and authorization procedures are required to allow researchers in multiple institutions to securely compare results and gain new insights. Funded by the European Union's Seventh Framework Programme under the International Rare Diseases Research Consortium (IRDiRC), RD-Connect is a global infrastructure project initiated in November 2012 that links genomic data with registries, biobanks, and clinical bioinformatics tools to produce a central research resource for rare diseases.
  •  
27.
  • Wallnau, Kurt C., 1958- (författare)
  • Predictability By Construction : Working the Architecture/Program Seam
  • 2010
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Contemporary software engineering practice overemphasizes the distinction of software design from software implementation, and designer (“software architect”) from implementor (“computer programmer”). In this contemporary meme, software architects are concerned with large-grained system structures, quality attributes that arise from these structures (security, availability, performance, etc.) and quality attribute tradeoff to satisfy conflicting stakeholder needs; programmers are concerned with low–level algorithms and data structures, program functionality, and with satisfying architectural intent. However, software is unique in that design and implementation are not cleanly separable. While architect and programmer may have many different design concerns, they also have many complementary and interacting concerns; their respective design practices must be well–integrated. Instead, contemporary architecture and programming practices are diverging. Architects are likely to regard programming as a routine production activity, while programmers are likely to regard architecture as a routine management activity; communication is hindered by a lack of shared vocabulary or appreciation of mutual concerns. Instead of effective integration, a gap has opened in software architecture and programming practice. The research reported here defines the architecture/program seam (“the Seam”), a region of overlap in software architecture and programming practice. The Seam emphasizes design concerns centered on achieving predictable runtime behavior. For a behavior to be predictable it must be described in a theory that must ultimately be consistent with basic theories of computation, and each such theory must have objective evidence to demonstrate that theory observations correspond to system observations. The validity of a theory will likely depend on invariants that can be expressed, and enforced, by means of theory–induced design rules. A system that satisfies the design rules of a theory is then regarded as having behavior that is predictable by construction with respect to that theory. Predictability by construction reduces uncertainty, and hence risk in design, and helps designers explain complex design decisions. The research reported here also defines prediction–enabled component technology (PECT) as a foundation technology to support the Seam, and demonstrates a prototype on industrial problems in electric grid substation control, industrial robot control, and desktop streaming audio. The prototype PECT extends a basic component technology of pure assembly (“Pin”) with theory extension points (“reasoning frameworks”) that are used to achieve predictability by construction. Reasoning frameworks for real–time performance and temporal–logic model checking have been developed, with statistical confidence intervals providing evidence of predictive quality for the former, and code–embeddable proof certificates providing evidence for the latter. Finally, the research reported here defines the Seam itself as inducing a new kind of evolutionary design problem, whose solutions require the integration of programming language theory, design theory, specialized theories of system behavior and deep systems expertise.
  •  
28.
  • Welin, Lennart, et al. (författare)
  • Prevalence of cardiovascular risk factors and the metabolic syndrome in middle-aged men and women in Gothenburg, Sweden
  • 2008
  • Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 8, s. 403-
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND Random samples of 50-year-old men living in Gothenburg have been examined every 10th year since 1963 with a focus on cardiovascular risk factors. The aims of the study were to acquire up-to-date information about risk factors in the fifth cohort of 50-year-old men and women, to re-examine those who were 50 years of age in 1993, and to analyse the prevalence of the metabolic syndrome (MetSyn) using different definitions. METHODS A random sample of men and women born in 1953 were examined in 2003-2004 for cardiovascular risk factors. Men born in 1943 and that participated in the examination in 1993 were also invited. Descriptive statistics were calculated. RESULTS The participation rate among men and women born in 1953 was 60 and 67% respectively. Among men born in 1943, the participation rate was 87%. The prevalence of obesity was from 15 to 17% (body mass index, BMI >or= 30) in the three samples. The prevalence of known diabetes was 4% among the 50-year-old men and 6% among the 60-year-old men, and 2% among the women. Increased fasting plasma glucose varied substantially from 4 to 33% depending on cut-off level and gender. Mean cholesterol was 5.4 to 5.5 mmol/l. Smoking was more common among women aged 50 (26%) than among men aged 50 (22%) and 60 years (15%). The prevalence of the MetSyn varied with the definition used: from 10 to 15.8% among the women, from 16.1 to 26% among 50-year-old men, and from 19.9 to 35% among the 60-year-old men. Only 5% of the men and women had no risk factors. CONCLUSION This study provides up-to-date information about the prevalence of cardiovascular risk factors and the MetSyn in middle-aged Swedish men and women. Different definitions of the MetSyn create confusion regarding which definition to use.
  •  
29.
  • Wilhelmsen, Lars, 1932, et al. (författare)
  • Factors associated with reaching 90 years of age : a study of men born in 1913 in Gothenburg, Sweden
  • 2011
  • Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 269:4, s. 441-451
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives. Increasing numbers of people reach old age. We wanted to identify variables of importance for reaching 90 years old and determine how the predictive ability of these variables might change over time. Setting and subjects. All men in the city of Gothenburg born in 1913 on dates divisible by 3, which is on the 3rd, 6th, 9th etc., were included in the study. Thus, 973 men were invited, and 855 were examined in 1963 at age 50. Further examinations were made at age 54, 60 and 67. Anthropometric data, lifestyle and parental factors, blood pressure, lung function, X-ray of heart and lungs and maximum work performance were recorded. The area under the receiver operating characteristic curve was used to analyse the predictive capacity of a variable. Results. A total of 111 men (13%) reached 90 years of age, men who reached 90 years were more likely at age 50 to be nonsmokers, consume less coffee, have higher socio-economic status and have low serum cholesterol levels than those who did not reach this age; however, at age 50 or 62, parents' survival was of no prognostic importance. Variables of greatest importance at higher ages were low blood pressure and measures related to good cardiorespiratory function. In multivariable analysis, including all examinations, being a nonsmoker, consuming small amounts of coffee, having high housing costs at age 50, good maximum working capacity and low serum cholesterol were related to a better chance of survival to age 90. Conclusions. Low levels of cardiovascular risk factors, high socio-economic status and good functional capacity, irrespective of parents' survival, characterize men destined to reach the age of 90.
  •  
30.
  • Wilhelmsen, Lars, 1932, et al. (författare)
  • Secular changes in cardiovascular risk factors and attack rate of myocardial infarction among men aged 50 in Gothenburg, Sweden. Accurate prediction using risk models
  • 2008
  • Ingår i: Journal of Internal Medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 263:6, s. 636-43
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS: Coronary risk factor changes were related to attack rate of acute myocardial infarction (AMI). METHODS AND RESULTS: Cross-sectional population samples of 50-year-old men were examined every 10th year from 1963 to 2003. Attack rates of AMI were recorded from 1975 to 2004. Prevalence of smoking decreased from 56% in 1963 to 22% in 2003. Leisure time physical activity decreased (n.s.), while psychological stress remained the same. Diabetes prevalence increased from 3.6% to 6.6%. Body mass index (BMI) increased from 24.8 to 26.4 kg m(-2). Blood pressures decreased from 138.2/90.6 to 134.7/84.9 mmHg (P = 0.00001). Serum total cholesterol decreased from 6.42 to 5.50 mmol L(-1) (P = 0.0001), but serum triglycerides increased from 1.26 to 1.71 mmol L(-1) (P = 0.0001). The multivariable risk according to total cholesterol, blood pressure and smoking for AMI decreased from the set value 1.0 in 1963 to 0.418. From 1975-1979 to 2000-2004 attack rates for AMI for the age groups 35-44, 45-54 and 55-64 declined to 45%, 46% and 45%, respectively. The 28-day case fatality declined from 30%, 38% and 46% to 12%, 16% and 20%. CONCLUSION: The more than 50% decline in attack rate of AMI during 30 years was comparable with the decline in risk factors.
  •  
31.
  • Zhong, You, et al. (författare)
  • Secular changes in cardiovascular risk factors in Swedish 50-year-old men over a 50-year period : The study of men born in 1913, 1923, 1933, 1943, 1953 and 1963
  • 2017
  • Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 24:6, s. 612-620
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: During the past decades, declining trends in mean cholesterol levels and smoking have been observed in Western Europe, whereas obesity and a sedentary lifestyle have increased. Simultaneously, there has been a marked decrease in mortality from cardiovascular (CV) diseases. Methods: The aim of the study was to determine whether these trends in CV risk factors continued over a period of 50 years. Six systematic or random population samples of 50-year-old men (n = 3563) living in Gothenburg, Sweden, were investigated between 1963 and 2013. Results: During the 50 years, mean body mass index (BMI) at 50 years of age increased by 2 kg/m(2), from 24.8 kg/m(2) in 1963 to 26.8 kg/m(2) in 2013 (p< 0.001). A decrease in systolic blood pressure of nearly 10mmHg was observed from 1963 to 1993, but was not sustained through the past two decades. Mean serum cholesterol fell from 6.42 (SD 1.12) mmol/L to 5.34 (SD 0.97) mmol/L. The prevalence of smoking at 50 years of age decreased markedly from 56.1% in 1963 to 11.9% in 2013. The number of participants with a sedentary lifestyle during leisure time decreased until 1993, but has remained unchanged since. In 2013, 50-year-old men had a 6.9-times higher likelihood of lacking CV risk factors than 50-year-old men in 1963 (95% confidence interval (CI): 3.5-13.3, p< 0.001). The odds ratio for having four or more risk factors was only 0.13 (95% CI: 0.062-0.29, p< 0.001). Conclusion: Despite increasing body weight, the total CV risk factor burden has decreased in 50-year-old men over the past 50 years.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-31 av 31
Typ av publikation
tidskriftsartikel (21)
konferensbidrag (4)
doktorsavhandling (2)
rapport (1)
bok (1)
forskningsöversikt (1)
visa fler...
bokkapitel (1)
visa färre...
Typ av innehåll
refereegranskat (22)
övrigt vetenskapligt/konstnärligt (9)
Författare/redaktör
Hansson, Per-Olof, 1 ... (13)
Svärdsudd, Kurt, 194 ... (8)
Svärdsudd, Kurt (8)
Rosengren, Annika, 1 ... (7)
Wilhelmsen, Lars, 19 ... (7)
Mandalenakis, Zachar ... (5)
visa fler...
Welin, Lennart (5)
Caidahl, Kenneth, 19 ... (4)
Fu, Michael, 1963 (4)
Persson, Carina Ulla ... (4)
Welin, Catharina, 19 ... (4)
Welin, L (4)
Berndes, Göran, 1966 (3)
Hansson, Julia, 1978 (3)
Hansson, Kurt (3)
Fischer, Günther (3)
Faaij, A. (3)
Prieler, S (3)
Londo, Marc (3)
de Wit, Marc (3)
Lensink, Sander (3)
Dellborg, Mikael, 19 ... (2)
Marsal, Karel (2)
Blomstrand, Christia ... (2)
Johansson, Saga (2)
Eriksson, Henry (2)
Hansson, Stefan R. (2)
Thunström, Erik, 198 ... (2)
Ladenvall, Per, 1972 (2)
Larsson, Tommy (2)
Grimby, Gunnar, 1933 (2)
Sebire, Neil J. (2)
Ambler, Gareth (2)
Gratacós, Eduard (2)
Figueras, Francesc (2)
Eriksson, Henry, 194 ... (2)
Ergatoudes, Constant ... (2)
Blomstrand, Ann (2)
Egeskog, Andrea, 198 ... (2)
Brodszki, Jana (2)
Malmberg, Jonas (2)
Björknäs, Hanna (2)
Zhong, You (2)
Junginger, M. (2)
Hecher, Kurt (2)
Velthuizen, H. van (2)
Hylander, Lars Danie ... (2)
Spencer, Rebecca (2)
Huertas-Ceballos, An ... (2)
Marlow, Neil (2)
visa färre...
Lärosäte
Uppsala universitet (22)
Göteborgs universitet (13)
Karolinska Institutet (6)
Chalmers tekniska högskola (4)
Lunds universitet (3)
Stockholms universitet (2)
visa fler...
Mälardalens universitet (1)
Linköpings universitet (1)
RISE (1)
visa färre...
Språk
Engelska (28)
Svenska (3)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (17)
Naturvetenskap (5)
Samhällsvetenskap (5)
Teknik (4)
Lantbruksvetenskap (1)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy