| 1. |
- Attia, Nour F., et al.
(författare)
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Iron oxide nanoparticles and their pharmaceutical applications
- 2022
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Ingår i: Applied Surface Science Advances. - : Elsevier BV. - 2666-5239. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- The importance of different polymorphic forms of iron oxide nanoparticles attracted a lot of attentions in various applications due to their unique electrical, optical and magnetic properties. Moreover, the excellent biocompatibility, high surface area, spherical shape, tunable nanoscale size and the availability of synthesis route make them desirable in various biological and pharmaceutical applications. To this aim, in this review, different synthesis methods of iron oxide nanoparticles were discussed, also the main characterization techniques used for elucidation of the iron oxide nanoparticles were reviewed. The exploitation of iron oxide nanoparticles-based systems as anticancer, antiviral, antimicrobial agents and its involvement in drug delivery system were reviewed in details. Additionally, the influence of nanoparticles size and the reagent type and conditions utilized in synthesis and their pharmaceutical applications was highlighted.
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| 2. |
- El-Seedi, Hesham, et al.
(författare)
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Gelatin nanofibers : Recent insights in synthesis, bio-medical applications and limitations
- 2023
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Ingår i: Heliyon. - : Elsevier. - 2405-8440. ; 9:5
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Forskningsöversikt (refereegranskat)abstract
- The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.
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| 3. |
- Hawash, Hamada B., et al.
(författare)
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Occurrence and spatial distribution of pharmaceuticals and personal care products (PPCPs) in the aquatic environment, their characteristics, and adopted legislations
- 2023
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Ingår i: Journal of Water Process Engineering. - : Elsevier. - 2214-7144. ; 52
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Forskningsöversikt (refereegranskat)abstract
- Pharmaceuticals and personal care products (PPCPs) residues are known to occur widely in the aquatic environments of industrialized and developing countries. Considerable progress has been made regarding to study of their exposure and distribution in aquatic environment. The spatial distribution and transformation of PPCPs have been investigated in the aquatic systems of different countries covering the five UN regions. As a result, the objectives of this review are focused on: (a) the global occurrence of PPCPs residues in aquatic systems, particularly in drinking/tap water, surface water, groundwater, and wastewater treatment plants (WWTPs), (b) widely prescribed pharmaceutical classes such as antibiotics, antidepressants, β-blockers, lipid regulators, nonsteroidal anti-inflammatory drugs (NSAIDs), etc. due to their potential adverse influences on the aquatic ecosystems and human health, (c) the spatial distribution of PPCPs in water bodies based on recently published data, (d) different regions in the world (e.g., USA, China, and Mediterranean basin) as case studies of contaminated areas, (e) the relation of occurrences with specific characteristics of frequently detected compounds, (f) the legislation and regulations implemented by countries/states governments were summarized and discussed, and finally, (g) future perspectives for research on PPCPs in the aquatic environment, which are explained regarded to the research gaps in current knowledge. The findings of this review indicate that the concentrations of PPCPs in the influents and effluents of WWTPs of the selected regions are much higher than in other water matrices. Additionally, there are significant variations in PPCPs concentrations between different countries and regions due to certain reasons.
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