| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
- Craddock, Nick, et al.
(författare)
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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720
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Tidskriftsartikel (refereegranskat)abstract
- Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
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| 3. |
- Abend, Sven, et al.
(författare)
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Terrestrial very-long-baseline atom interferometry : Workshop summary
- 2024
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Ingår i: AVS Quantum Science. - : American Institute of Physics (AIP). - 2639-0213. ; 6:2
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Forskningsöversikt (refereegranskat)abstract
- This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
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| 4. |
- Sawcer, Stephen, et al.
(författare)
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- 2011
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 476:7359, s. 214-219
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Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.
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| 5. |
- Bombarda, F., et al.
(författare)
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Runaway electron beam control
- 2019
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Campbell, Brittany B., et al.
(författare)
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Comprehensive Analysis of Hypermutation in Human Cancer
- 2017
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Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 171:5
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 Elsevier Inc. We present an extensive assessment of mutation burden through sequencing analysis of > 81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load. Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation. Mutagens, such as UV light, were implicated in unexpected cancers, including sarcomas and lung tumors. The order of mutational signatures identified previous treatment and germline replication repair deficiency, which improved management of patients and families. These data will inform tumor classification, genetic testing, and clinical trial design. A large-scale analysis of hypermutation in human cancers provides insights into tumor evolution dynamics and identifies clinically actionable mutation signatures.
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| 7. |
- Ercan, Ayse Bahar, et al.
(författare)
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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
- 2024
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Ingår i: The Lancet Oncology. - 1470-2045. ; 25:5, s. 668-682
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Tidskriftsartikel (refereegranskat)abstract
- Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD.In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries. Clinical data were extracted from the IRRDC database, medical records, and physician-completed case record forms. The primary objective was to describe the clinical features, cancer spectrum, and biology of the condition. Secondary objectives included estimations of cancer incidence and of the impact of the specific mismatch-repair gene and genotype on cancer onset and survival, including after cancer surveillance and immunotherapy interventions.We analysed data from 201 patients (103 males, 98 females) enrolled between June 5, 2007 and Sept 9, 2022. Median age at diagnosis of CMMRD or a related cancer was 8·9 years (IQR 5·9-12·6), and median follow-up from diagnosis was 7·2 years (3·6-14·8). Endogamy among minorities and closed communities contributed to high homozygosity within countries with low consanguinity. Frequent dermatological manifestations (117 [93%] of 126 patients with complete data) led to a clinical overlap with neurofibromatosis type 1 (35 [28%] of 126). 339 cancers were reported in 194 (97%) of 201 patients. The cumulative cancer incidence by age 18 years was 90% (95% CI 80-99). Median time between cancer diagnoses for patients with more than one cancer was 1·9 years (IQR 0·8-3·9). Neoplasms developed in 15 organs and included early-onset adult cancers. CNS tumours were the most frequent (173 [51%] cancers), followed by gastrointestinal (75 [22%]), haematological (61 [18%]), and other cancer types (30 [9%]). Patients with CNS tumours had the poorest overall survival rates (39% [95% CI 30-52] at 10 years from diagnosis; log-rank p<0·0001 across four cancer types), followed by those with haematological cancers (67% [55-82]), gastrointestinal cancers (89% [81-97]), and other solid tumours (96% [88-100]). All cancers showed high mutation and microsatellite indel burdens, and pathognomonic mutational signatures. MLH1 or MSH2 variants caused earlier cancer onset than PMS2 or MSH6 variants, and inferior survival (overall survival at age 15 years 63% [95% CI 55-73] for PMS2, 49% [35-68] for MSH6, 19% [6-66] for MLH1, and 0% for MSH2; p<0·0001). Frameshift or truncating variants within the same gene caused earlier cancers and inferior outcomes compared with missense variants (p<0·0001). The greater deleterious effects of MLH1 and MSH2 variants as compared with PMS2 and MSH6 variants persisted despite overall improvements in survival after surveillance or immune checkpoint inhibitor interventions.The very high cancer burden and unique genomic landscape of CMMRD highlight the benefit of comprehensive assays in timely diagnosis and precision approaches toward surveillance and immunotherapy. These data will guide the clinical management of children and patients who survive into adulthood with CMMRD.The Canadian Institutes for Health Research, Stand Up to Cancer, Children's Oncology Group National Cancer Institute Community Oncology Research Program, Canadian Cancer Society, Brain Canada, The V Foundation for Cancer Research, BioCanRx, Harry and Agnieszka Hall, Meagan's Walk, BRAINchild Canada, The LivWise Foundation, St Baldrick Foundation, Hold'em for Life, and Garron Family Cancer Center.
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| 8. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 9. |
- Maasri, Alain, et al.
(författare)
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A global agenda for advancing freshwater biodiversity research
- 2022
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 25:2, s. 255-263
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Tidskriftsartikel (refereegranskat)abstract
- Global freshwater biodiversity is declining dramatically, and meeting the challenges of this crisis requires bold goals and the mobilisation of substantial resources. While the reasons are varied, investments in both research and conservation of freshwater biodiversity lag far behind those in the terrestrial and marine realms. Inspired by a global consultation, we identify 15 pressing priority needs, grouped into five research areas, in an effort to support informed stewardship of freshwater biodiversity. The proposed agenda aims to advance freshwater biodiversity research globally as a critical step in improving coordinated actions towards its sustainable management and conservation.
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| 10. |
- Marina, Neyssa M., et al.
(författare)
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Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1) : an open-label, international, randomised controlled trial
- 2016
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Ingår i: The Lancet Oncology. - 1470-2045. ; 17:10, s. 1396-1408
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Tidskriftsartikel (refereegranskat)abstract
- Background We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. Methods EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diagnosed, resectable, high-grade osteosarcoma aged 40 years or younger were eligible for randomisation. Patients were randomly assigned (1:1) to receive either postoperative cisplatin, doxorubicin, and methotrexate (MAP) or MAP plus ifosfamide and etoposide (MAPIE) using concealed permuted blocks with three stratification factors: trial group; location of tumour (proximal femur or proximal humerus vs other limb vs axial skeleton); and presence of metastases (no vs yes or possible). The MAP regimen consisted of cisplatin 120 mg/m2, doxorubicin 37·5 mg/m2 per day on days 1 and 2 (on weeks 1 and 6) followed 3 weeks later by high-dose methotrexate 12 g/m2 over 4 h. The MAPIE regimen consisted of MAP as a base regimen, with the addition of high-dose ifosfamide (14 g/m2) at 2·8 g/m2 per day with equidose mesna uroprotection, followed by etoposide 100 mg/m2 per day over 1 h on days 1–5. The primary outcome measure was event-free survival measured in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT00134030. Findings Between April 14, 2005, and June 30, 2011, 2260 patients were registered from 325 sites in 17 countries. 618 patients with poor response were randomly assigned; 310 to receive MAP and 308 to receive MAPIE. Median follow-up was 62·1 months (IQR 46·6–76·6); 62·3 months (IQR 46·9–77·1) for the MAP group and 61·1 months (IQR 46·5–75·3) for the MAPIE group. 307 event-free survival events were reported (153 in the MAP group vs 154 in the MAPIE group). 193 deaths were reported (101 in the MAP group vs 92 in the MAPIE group). Event-free survival did not differ between treatment groups (hazard ratio [HR] 0·98 [95% CI 0·78–1·23]); hazards were non-proportional (p=0·0003). The most common grade 3–4 adverse events were neutropenia (268 [89%] patients in MAP vs 268 [90%] in MAPIE), thrombocytopenia (231 [78% in MAP vs 248 [83%] in MAPIE), and febrile neutropenia without documented infection (149 [50%] in MAP vs 217 [73%] in MAPIE). MAPIE was associated with more frequent grade 4 non-haematological toxicity than MAP (35 [12%] of 301 in the MAP group vs 71 [24%] of 298 in the MAPIE group). Two patients died during postoperative therapy, one from infection (although their absolute neutrophil count was normal), which was definitely related to their MAP treatment (specifically doxorubicin and cisplatin), and one from left ventricular systolic dysfunction, which was probably related to MAPIE treatment (specifically doxorubicin). One suspected unexpected serious adverse reaction was reported in the MAP group: bone marrow infarction due to methotrexate. Interpretation EURAMOS-1 results do not support the addition of ifosfamide and etoposide to postoperative chemotherapy in patients with poorly responding osteosarcoma because its administration was associated with increased toxicity without improving event-free survival. The results define standard of care for this population. New strategies are required to improve outcomes in this setting. Funding UK Medical Research Council, National Cancer Institute, European Science Foundation, St Anna Kinderkrebsforschung, Fonds National de la Recherche Scientifique, Fonds voor Wetenschappelijk Onderzoek-Vlaanderen, Parents Organization, Danish Medical Research Council, Academy of Finland, Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, Federal Ministry of Education and Research, Semmelweis Foundation, ZonMw (Council for Medical Research), Research Council of Norway, Scandinavian Sarcoma Group, Swiss Paediatric Oncology Group, Cancer Research UK, National Institute for Health Research, University College London Hospitals, and Biomedical Research Centre.
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| 11. |
- Rands, Chris M., et al.
(författare)
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Insights into the evolution of Darwin's finches from comparative analysis of the Geospiza magnirostris genome sequence
- 2013
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 14, s. 95-
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Tidskriftsartikel (refereegranskat)abstract
- Background: A classical example of repeated speciation coupled with ecological diversification is the evolution of 14 closely related species of Darwin's (Galapagos) finches (Thraupidae, Passeriformes). Their adaptive radiation in the Galapagos archipelago took place in the last 2-3 million years and some of the molecular mechanisms that led to their diversification are now being elucidated. Here we report evolutionary analyses of genome of the large ground finch, Geospiza magnirostris. Results: 13,291 protein-coding genes were predicted from a 991.0 Mb G. magnirostris genome assembly. We then defined gene orthology relationships and constructed whole genome alignments between the G. magnirostris and other vertebrate genomes. We estimate that 15% of genomic sequence is functionally constrained between G. magnirostris and zebra finch. Genic evolutionary rate comparisons indicate that similar selective pressures acted along the G. magnirostris and zebra finch lineages suggesting that historical effective population size values have been similar in both lineages. 21 otherwise highly conserved genes were identified that each show evidence for positive selection on amino acid changes in the Darwin's finch lineage. Two of these genes (Igf2r and Pou1f1) have been implicated in beak morphology changes in Darwin's finches. Five of 47 genes showing evidence of positive selection in early passerine evolution have cilia related functions, and may be examples of adaptively evolving reproductive proteins. Conclusions: These results provide insights into past evolutionary processes that have shaped G. magnirostris genes and its genome, and provide the necessary foundation upon which to build population genomics resources that will shed light on more contemporaneous adaptive and non-adaptive processes that have contributed to the evolution of the Darwin's finches.
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| 12. |
- Zhukova, Nataliya, et al.
(författare)
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WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
- 2014
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Ingår i: Acta neuropathologica communications. - : Springer Science and Business Media LLC. - 2051-5960. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test radioresistance of TP53 mutations and the radiosensitizing effect of WNT activation on tumors and the developing brain. Children with WNT/TP53 mutant medulloblastoma had higher 5-year survival than those with SHH/TP53 mutant tumours (100% and 36.6%±8.7%, respectively (p<0.001)). Introduction of TP53 mutation into medulloblastoma cells induced radioresistance (survival fractions at 2Gy (SF2) of 89%±2% vs. 57.4%±1.8% (p<0.01)). In contrast, beta-catenin mutation sensitized TP53 mutant cells to radiation (p<0.05). Lithium, an activator of the WNT pathway, sensitized TP53 mutant medulloblastoma to radiation (SF2 of 43.5%±1.5% in lithium treated cells vs. 56.6±3% (p<0.01)) accompanied by increased number of gammaH2AX foci. Normal neural stem cells were protected from lithium induced radiation damage (SF2 of 33%±8% for lithium treated cells vs. 27%±3% for untreated controls (p=0.05). Poor survival of patients with TP53 mutant medulloblastoma may be related to radiation resistance. Since constitutive activation of the WNT pathway by lithium sensitizes TP53 mutant medulloblastoma cells and protect normal neural stem cells from radiation, this oral drug may represent an attractive novel therapy for high-risk medulloblastomas.
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| 13. |
-
- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:9
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Tidskriftsartikel (refereegranskat)
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| 14. |
-
- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Forskningsöversikt (refereegranskat)
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| 15. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 16. |
- Aad, G, et al.
(författare)
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Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period
- 2016
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Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was observed, is presented. Correlations between backgrounds and beam intensity losses in special fills with very high β∗ are studied. © 2016 CERN for the benefit of the ATLAS collaboration.
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| 17. |
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| 18. |
- Aad, G., et al.
(författare)
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Measurement of exclusive gamma gamma -> l(+)l(-) production in proton-proton collisions at root s=7 TeV with the ATLAS detector
- 2015
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 749, s. 242-261
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Tidskriftsartikel (refereegranskat)abstract
- This Letter reports a measurement of the exclusive gamma gamma -> l(+)l(-) (l = e, mu) cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV by the ATLAS experiment at the LHC, based on an integrated luminosity of 4.6 fb(-1). For the electron or muon pairs satisfying exclusive selection criteria, a fit to the dilepton acoplanarity distribution is used to extract the fiducial cross-sections. The cross-section in the electron channel is determined to be sigma(excl)(gamma gamma -> e+e-) = 0.428 +/- 0.035 (stat.) +/- 0.018 (syst.) pbfor a phase-space region with invariant mass of the electron pairs greater than 24GeV, in which both electrons have transverse momentum p(T) > 12 GeV and pseudorapidity vertical bar eta vertical bar < 2.4. For muon pairs with invariant mass greater than 20GeV, muon transverse momentum pT> 10 GeV and pseudorapidity vertical bar eta vertical bar < 2.4, the cross-section is determined to be sigma(excl)(gamma gamma -> mu+mu-) = 0.628 +/- 0.032(stat.) +/- 0.021 (syst.) pb. When proton absorptive effects due to the finite size of the proton are taken into account in the theory calculation, the measured cross-sections are found to be consistent with the theory prediction. (C) 2015 CERN for the benefit of the ATLAS Collaboration. Published by Elsevier B.V.
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| 19. |
- Aad, G, et al.
(författare)
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Measurement of the ZZ production cross section in pp collisions at √s = 13 TeV with the ATLAS detector
- 2016
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Ingår i: Physical Review Letters. - : American Physical Society. - 1079-7114 .- 0031-9007. ; 116:10
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Tidskriftsartikel (refereegranskat)abstract
- The ZZ production cross section in proton-proton collisions at 13 TeV center-of-mass energy is measured using 3.2 fb-1 of data recorded with the ATLAS detector at the Large Hadron Collider. The considered Z boson candidates decay to an electron or muon pair of mass 66-116 GeV. The cross section is measured in a fiducial phase space reflecting the detector acceptance. It is also extrapolated to a total phase space for Z bosons in the same mass range and of all decay modes, giving 16.7-2.0+2.2(stat)+0.9-0.7(syst)+1.0-0.7(lumi) pb. The results agree with standard model predictions. © 2016 CERN. Published by the American Physical Society under the terms of the "http://creativecommons.org/licenses/by/3.0/" Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
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| 20. |
- Aad, G, et al.
(författare)
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Performance of b-jet identification in the ATLAS experiment
- 2016
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Ingår i: Journal of Instrumentation. - : Institute of Physics (IOP). - 1748-0221. ; 11:4
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Tidskriftsartikel (refereegranskat)abstract
- The identification of jets containing b hadrons is important for the physics programme of the ATLAS experiment at the Large Hadron Collider. Several algorithms to identify jets containing b hadrons are described, ranging from those based on the reconstruction of an inclusive secondary vertex or the presence of tracks with large impact parameters to combined tagging algorithms making use of multi-variate discriminants. An independent b-tagging algorithm based on the reconstruction of muons inside jets as well as the b-tagging algorithm used in the online trigger are also presented. The b-jet tagging efficiency, the c-jet tagging efficiency and the mistag rate for light flavour jets in data have been measured with a number of complementary methods. The calibration results are presented as scale factors defined as the ratio of the efficiency (or mistag rate) in data to that in simulation. In the case of b jets, where more than one calibration method exists, the results from the various analyses have been combined taking into account the statistical correlation as well as the correlation of the sources of systematic uncertainty. © CERN 2016 for the benefit of the ATLAS collaboration, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl.
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| 21. |
- Abulaiti, Yiming, et al.
(författare)
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A new method to distinguish hadronically decaying boosted Z bosons from W bosons using the ATLAS detector
- 2016
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:5
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Tidskriftsartikel (refereegranskat)abstract
- The distribution of particles inside hadronic jets produced in the decay of boosted W and Z bosons can be used to discriminate such jets from the continuum background. Given that a jet has been identified as likely resulting from the hadronic decay of a boosted W or Z boson, this paper presents a technique for further differentiating Z bosons from W bosons. The variables used are jet mass, jet charge, and a b-tagging discriminant. A likelihood tagger is constructed from these variables and tested in the simulation of W' -> WZ for bosons in the transverse momentum range 200 GeV < p(T) < 400 GeV in root s = 8 TeV pp collisions with the ATLAS detector at the LHC. For Z-boson tagging efficiencies of epsilon(Z) = 90, 50, and 10 %, one can achieve W+-boson tagging rejection factors (1/epsilon(W+)) of 1.7, 8.3 and 1000, respectively. It is not possible to measure these efficiencies in the data due to the lack of a pure sample of high p(T), hadronically decaying Z bosons. However, the modelling of the tagger inputs for boosted W bosons is studied in data using a t (t) over bar -enriched sample of events in 20.3 fb(-1) of data at root s = 8 TeV. The inputs are well modelled within uncertainties, which builds confidence in the expected tagger performance.
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| 22. |
- Abulaiti, Yiming, et al.
(författare)
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A search for prompt lepton-jets in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :2
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Tidskriftsartikel (refereegranskat)abstract
- A search is presented for a new, light boson with a mass of about 1 GeV and decaying promptly to jets of collimated electrons and/or muons (lepton-jets). The analysis is performed with 20.3 fb(-1) of data collected by the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a centre-of-mass energy of 8 TeV. Events are required to contain at least two lepton-jets. This study finds no statistically significant deviation from predictions of the Standard Model and places 95% confidence-level upper limits on the contribution of new phenomena beyond the SM, incuding SUSY-portal and Higgs-portal models, on the number of events with lepton-jets.
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| 23. |
- Abulaiti, Yiming, et al.
(författare)
-
A search for top squarks with R-parity-violating decays to all-hadronic final states with the ATLAS detector in root s=8 TeV proton-proton collisions
- 2016
-
Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :6
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the pair production of top squarks, each with R-parity-violating decays into two Standard Model quarks, is performed using 17.4 fb(-1) of root s = 8 TeV proton-proton collision data recorded by the ATLAS experiment at the LITC. Each top squark is assumed to decay to a b- and an 8-quark, leading to four quarks in the final state. Background discrimination is achieved with the use of b-tagging and selections on the mass and substructure of large-radius jets, providing sensitivity to top squark masses as low as 100 GeV. No evidence of an excess beyond the Standard Model background prediction is observed and top squalls decaying to bs are excluded for top squark masses in the range 100 <= m((t) over tilde) <= 315 GeV at 95% confidence level.
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| 24. |
- Abulaiti, Yiming, et al.
(författare)
-
Charged-particle distributions in root s=13 TeV pp interactions measured with the ATLAS detector at the LHC
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 758, s. 67-88
-
Tidskriftsartikel (refereegranskat)abstract
- Charged-particle distributions are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV, using a data sample of nearly 9 million events, corresponding to an integrated luminosity of 170 mu b(-1), recorded by the ATLAS detector during a special Large Hadron Collider fill. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the dependence of the mean transverse momentum on the charged-particle multiplicity are presented. The measurements are performed with charged particles with transverse momentum greater than 500 MeV and absolute pseudorapidity less than 2.5, in events with at least one charged particle satisfying these kinematic requirements. Additional measurements in a reduced phase space with absolute pseudorapidity less than 0.8 are also presented, in order to compare with other experiments. The results are corrected for detector effects, presented as particle-level distributions and are compared to the predictions of various Monte Carlo event generators.
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| 25. |
- Abulaiti, Yiming, et al.
(författare)
-
Combination of searches for WW, WZ, and ZZ resonances in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 755, s. 285-305
-
Tidskriftsartikel (refereegranskat)abstract
- The ATLAS experiment at the CERN Large Hadron Collider has performed searches for new, heavy bosons decaying to WW, WZ and ZZ final states in multiple decay channels using 20.3 fb(-1) of pp collision data at root s = 8 TeV. In the current study, the results of these searches are combined to provide a more stringent test of models predicting heavy resonances with couplings to vector bosons. Direct searches for a charged diboson resonance decaying to WZ in the l nu l'l' (l = mu, e), llq (q) over bar, l nu q (q) over bar and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WZ bosons are compared with predictions of an extended gauge model with a heavy W' boson. In addition, direct searches for a neutral diboson resonance decaying to WW and ZZ in the llq (q) over bar, l nu q (q) over bar, and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WW and ZZ bosons are compared with predictions for a heavy, spin-2 graviton in an extended Randall-Sundrum model where the Standard Model fields are allowed to propagate in the bulk of the extra dimension.
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| 26. |
- Abulaiti, Yiming, et al.
(författare)
-
Dijet production in root s=7 TeV pp collisions with large rapidity gaps at the ATLAS experiment
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 754, s. 214-234
-
Tidskriftsartikel (refereegranskat)abstract
- A 6.8 nb(-1) sample of pp collision data collected under low-luminosity conditions at root s = 7 TeV by the ATLAS detector at the Large Hadron Collider is used to study diffractive dijet production. Events containing at least two jets with p(T) > 20 GeV are selected and analysed in terms of variables which discriminate between diffractive and non-diffractive processes. Cross sections are measured differentially in Delta eta(F), the size of the observable forward region of pseudorapidity which is devoid of hadronic activity, and in an estimator, (xi) over tilde, of the fractional momentum loss of the proton assuming single diffractive dissociation (pp -> pX). Model comparisons indicate a dominant non-diffractive contribution up to moderately large Delta eta(F) and small (xi) over tilde, with a diffractive contribution which is significant at the highest Delta eta(F) and the lowest (xi) over tilde. The rapidity-gap survival probability is estimated from comparisons of the data in this latter region with predictions based on diffractive parton distribution functions.
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| 27. |
- Abulaiti, Yiming, et al.
(författare)
-
Evidence for single top-quark production in the s-channel in proton-proton collisions at root s=8 TeV with the ATLAS detector using the Matrix Element Method
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 756, s. 228-246
-
Tidskriftsartikel (refereegranskat)abstract
- This Letter presents evidence for single top-quark production in the s-channel using proton-proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS detector at the CERN Large Hadron Collider. The analysis is performed on events containing one isolated electron or muon, large missing transverse momentum and exactly two b-tagged jets in the final state. The analysed data set corresponds to an integrated luminosity of 20.3 fb(-1). The signal is extracted using a maximum-likelihood fit of a discriminant which is based on the matrix element method and optimized in order to separate single-top-quark s-channel events from the main background contributions, which are top-quark pair production and W boson production in association with heavy-flavour jets. The measurement leads to an observed signal significance of 3.2 standard deviations and a measured cross-section of sigma s = 4.8 +/- 0.8(stat.)(-1.3)(+1.6)(syst.) pb, which is consistent with the Standard Model expectation. The expected significance for the analysis is 3.9 standard deviations.
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| 28. |
- Abulaiti, Yiming, et al.
(författare)
-
Identification of high transverse momentum top quarks in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :6
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents studies of the performance of several jet-substructure techniques, which are used to identify hadronically decaying top quarks with high transverse momentum contained in large-radius jets. The efficiency of identifying top quarks is measured using a sample of top-quark pairs and the rate of wrongly identifying jets from other quarks or gluons as top quarks is measured using multijet events collected with the ATLAS experiment in 20.3 fb(-1) of 8TeV proton-proton collisions at the Large Hadron Collider. Predictions from Monte Carlo simulations are found to provide an accurate description of the performance. The techniques are compared in terms of signal efficiency and background rejection using simulations, covering a larger range in jet transverse momenta than accessible in the dataset. Additionally, a novel technique is developed that is optimized to reconstruct top quarks in events with many jets.
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| 29. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of D-*+/-, D-+/- and D-S(+/-) meson production cross sections in pp collisions at root s=7 TeV with the ATLAS detector
- 2016
-
Ingår i: Nuclear Physics B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 907, s. 717-763
-
Tidskriftsartikel (refereegranskat)abstract
- The production of D*(+/-), D-+/- and D-S(+/-) charmed mesons has been measured with the ATLAS detector in pp collisions at,/7s = 7 TeV at the LHC, using data corresponding to an integrated luminosity of 280 nb(-)1(.) The charmed mesons have been reconstructed in the range of transverse momentum 3.5 < p(T)(D) < 100 GeV and pseudorapidity vertical bar eta(D)vertical bar < 2.1. The differential cross sections as a function of transverse momentum and pseudorapidity were measured for D*(+/-) and D-+/- production. The next-to-leading-order QCD predictions are consistent with the data in the visible kinematic region within the large theoretical uncertainties. Using the visible D cross sections and an extrapolation to the full kinematic phase space, the strangeness -suppression factor in charm fragmentation, the fraction of charged non -strange D mesons produced in a vector state, and the total cross section of charm production at root s = 7 TeV were derived.
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| 30. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of event-shape observables in Z -> l(+)l(-) events in pp collisions at root s=7 TeV with the ATLAS detector at the LHC
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:7
-
Tidskriftsartikel (refereegranskat)abstract
- Event-shape observables measured using charged particles in inclusive Z-boson events are presented, using the electron and muon decay modes of the Z bosons. The measurements are based on an integrated luminosity of 1.1 fb(-1) of proton-proton collisions recorded by the ATLAS detector at the LHC at a centre-of-mass energy root s = 7 TeV. Charged-particle distributions, excluding the lepton-antilepton pair from the Z-boson decay, are measured in different ranges of transverse momentum of the Z boson. Distributions include multiplicity, scalar sum of transverse momenta, beam thrust, transverse thrust, spherocity, and F-parameter, which are in particular sensitive to properties of the underlying event at small values of the Z-boson transverse momentum. The measured observables are compared with predictions from PYTHIA 8, Sherpa, and HERWIG 7. Typically, all three Monte Carlo generators provide predictions that are in better agreement with the data at high Z-boson transverse momenta than at low Z-boson transverse momenta, and for the observables that are less sensitive to the number of charged particles in the event.
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| 31. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:2
-
Tidskriftsartikel (refereegranskat)abstract
- This paper reports inclusive and differential measurements of the t (t) over bar charge asymmetry A(C) in 20.3 fb(-1) of root s = 8 TeV pp collisions recorded by the ATLAS experiment at the Large Hadron Collider at CERN. Three differential measurements are performed as a function of the invariant mass, transverse momentum and longitudinal boost of the t (t) over bar system. The t (t) over bar pairs are selected in the single-lepton channels (e or mu) with at least four jets, and a likelihood fit is used to reconstruct the t (t) over bar event kinematics. A Bayesian unfolding procedure is performed to infer the asymmetry at parton level from the observed data distribution. The inclusive t (t) over bar charge asymmetry is measured to be A(C) = 0.009 +/- 0.005 (stat. + syst.). The inclusive and differential measurements are compatible with the values predicted by the Standard Model.
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| 32. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of the dependence of transverse energy production at large pseudorapidity on the hard-scattering kinematics of proton-proton collisions at root s=2.76 TeV with ATLAS
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 756, s. 10-28
-
Tidskriftsartikel (refereegranskat)abstract
- The relationship between jet production in the central region and the underlying-event activity in a pseudorapidity-separated region is studied in 4.0 pb(-1) of root s = 2.76 TeV pp collision data recorded with the ATLAS detector at the LHC. The underlying event is characterised through measurements of the average value of the sum of the transverse energy at large pseudorapidity downstream of one of the protons, which are reported here as a function of hard-scattering kinematic variables. The hard scattering is characterised by the average transverse momentum and pseudorapidity of the two highest transverse momentum jets in the event. The dijet kinematics are used to estimate, on an event-by-event basis, the scaled longitudinal momenta of the hard-scattered partons in the target and projectile beam-protons moving toward and away from the region measuring transverse energy, respectively. Transverse energy production at large pseudorapidity is observed to decrease with a linear dependence on the longitudinal momentum fraction in the target proton and to depend only weakly on that in the projectile proton. The results are compared to the predictions of various Monte Carlo event generators, which qualitatively reproduce the trends observed in data but generally underpredict the overall level of transverse energy at forward pseudorapidity.
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| 33. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of the differential cross-section of highly boosted top quarks as a function of their transverse momentum in root s=8 TeV proton-proton collisions using the ATLAS detector
- 2016
-
Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 1550-7998 .- 1550-2368. ; 93:3
-
Tidskriftsartikel (refereegranskat)abstract
- The differential cross-section for pair production of top quarks with high transverse momentum is measured in 20.3 fb(-1) of proton-proton collisions at a center-of-mass energy of 8 TeV. The measurement is performed for t (t) over bar events in the lepton + jets channel. The cross-section is reported as a function of the hadronically decaying top quark transverse momentum for values above 300 GeV. The hadronically decaying top quark is reconstructed as an anti-k(t) jet with radius parameter R = 1.0 and identified with jet substructure techniques. The observed yield is corrected for detector effects to obtain a cross-section at particle level in a fiducial region close to the event selection. A parton-level cross-section extrapolated to the full phase space is also reported for top quarks with transverse momentum above 300 GeV. The predictions of a majority of next-to-leading-order and leading-order matrix-element Monte Carlo generators are found to agree with the measured cross-sections.
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| 34. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of the differential cross-sections of prompt and non-prompt production of J/psi and psi(2S) in pp collisions at root s=7 and 8 TeV with the ATLAS detector
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:5
-
Tidskriftsartikel (refereegranskat)abstract
- The production rates of prompt and non-prompt J/psi and psi(2S) mesons in their dimuon decay modes are measured using 2.1 and 11.4 fb(-1) of data collected with the ATLAS experiment at the Large Hadron Collider, in proton-proton collisions at root s = 7 and 8 respectively. Production cross-sections for prompt as well as non-prompt sources, ratios of psi(2S) to J/psi production, and the fractions of non-prompt production for J/psi and psi(2S) are measured as a function of meson transverse momentum and rapidity. The measurements are compared to theoretical predictions.
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| 35. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of the inclusive isolated prompt photon cross section in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :8, s. 1-42
-
Tidskriftsartikel (refereegranskat)abstract
- A measurement of the cross section for the inclusive production of isolated prompt photons in proton-proton collisions at a centre-of-mass energy of root s = 8 TeV is presented. The measurement covers the pseudorapidity ranges vertical bar eta(gamma)vertical bar < 1.37 and 1.56 aecurrency sign vertical bar eta(gamma)vertical bar < 2.37 in the transverse energy range 25 < E-T(gamma) < 1500 GeV. The results are based on an integrated luminosity of 20.2 fb(-1), recorded by the ATLAS detector at the LHC. Photon candidates are identified by combining information from the calorimeters and the inner tracker. The background is subtracted using a data-driven technique, based on the observed calorimeter shower-shape variables and the deposition of hadronic energy in a narrow cone around the photon candidate. The measured cross sections are compared with leading-order and next-to-leading order perturbative QCD calculations and are found to be in a good agreement over ten orders of magnitude.
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| 36. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of the transverse momentum and phi(eta)*. distributions of Drell-Yan lepton pairs in proton-proton collisions at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:5
-
Tidskriftsartikel (refereegranskat)abstract
- Distributions of transverse momentum p(T)(ll) and the related angular variable phi(eta)*. of Drell-Yan lepton pairs are measured in 20.3 fb(-1) of proton-proton collisions at root s = 8 TeV with the ATLAS detector at the LHC. Measurements in electron-pair and muon-pair final states are corrected for detector effects and combined. Compared to previous measurements in proton-proton collisions at root s = 7 TeV, these new measurements benefit from a larger data sample and improved control of systematic uncertainties. Measurements are performed in bins of lepton-pair mass above, around and below the Z-boson mass peak. The data are compared to predictions from perturbative and resummed QCD calculations. For values of phi(eta)*. < 1 the predictions from the Monte Carlo generator ResBos are generally consistent with the data within the theoretical uncertainties. However, at larger values of phi(eta)*. this is not the case. Monte Carlo generators based on the parton-shower approach are unable to describe the data over the full range of p(T)(ll) while the fixed-order prediction of Dynnlo falls below the data at high values of p(T)(ll). ResBos and the parton-shower Monte Carlo generators provide a much better description of the evolution of the phi(eta)*. and p(T)(ll) distributions as a function of lepton-pair mass and rapidity than the basic shape of the data.
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| 37. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurement of total and differential W plus w- production cross sections in proton-proton collisions at root s=8 TeV with the ATLAS detector and limits on anomalous triple-gauge-boson couplings
- 2016
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :9
-
Tidskriftsartikel (refereegranskat)abstract
- The production of W boson pairs in proton-proton collisions at root s = 8TeV is studied using data corresponding to 20.3 fb(-1) of integrated luminosity collected by the ATLAS detector during 2012 at the CERN Large Hadron Collider. The W bosons are reconstructed using their leptonic decays into electrons or muons and neutrinos. Events with reconstructed jets are not included in the candidate event sample. A total of 6636 W W candidate events are observed. Measurements are performed in fiducial regions closely approximating the detector acceptance. The integrated measurement is corrected for all acceptance effects and for the W branching fractions to leptons in order to obtain the total W W production cross section, which is found to be 71.1 +/- 1.1( stat) + (5.7) (5.0) (syst) +/- 1 : 4( lumi) pb. This agrees with the next-to-next-to-leading-order Standard Model prediction of 63.2(+1.6) (-1.4) (scale) +/- 1.2(PDF) pb. Fiducial differential cross sections are measured as a function of each of six kinematic variables. The distribution of the transverse momentum of the leading lepton is used to set limits on anomalous triple-gauge-boson couplings.
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| 38. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurements of four-lepton production in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 753, s. 552-572
-
Tidskriftsartikel (refereegranskat)abstract
- The four-lepton (4l, l = e, mu) production cross section is measured in the mass range from 80 to 1000GeV using 20.3 fb(-1)of data in pp collisions at root s = 8 TeV collected with the ATLAS detector at the LHC. The 4l events are produced in the decays of resonant Zand Higgs bosons and the nonresonant ZZcontinuum originating from q (q) over bar, gg, and qg initial states. A total of 476 signal candidate events are observed with a background expectation of 26.2 +/- 3.6 events, enabling the measurement of the integrated cross section and the differential cross section as a function of the invariant mass and transverse momentum of the four-lepton system. In the mass range above 180GeV, assuming the theoretical constraint on the q (q) over bar production cross section calculated with perturbative NNLO QCD and NLO electroweak corrections, the signal strength of the gluon-fusion component relative to its leading-order prediction is determined to be mu(gg) = 2.4 +/- 1.0(stat.) +/- 0.5(syst.) +/- 0.8(theory). (C) 2015 CERN for the benefit of the ATLAS Collaboration.
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| 39. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurements of the charge asymmetry in top-quark pair production in the dilepton final state at root s=8 TeV with the ATLAS detector
- 2016
-
Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010. ; 94:3
-
Tidskriftsartikel (refereegranskat)abstract
- Measurements of the top-antitop quark pair production charge asymmetry in the dilepton channel, characterized by two high-p(T) leptons (electrons or muons), are presented using data corresponding to an integrated luminosity of 20.3 fb(-1) from pp collisions at a center-of-mass energy root s = 8 TeV collected with the ATLAS detector at the Large Hadron Collider at CERN. Inclusive and differential measurements as a function of the invariant mass, transverse momentum, and longitudinal boost of the tt system arc performed both in the full phase space and in a fiducial phase space closely matching the detector acceptance. Two observables are studied: A(c)(ll) based on the selected leptons and A(c)(tt) based on the reconstructed tt final state. The inclusive asymmetries are measured in the full phase space to be A(c)(ll)= 0.008 +/- 0.006 and A(c)(tt)= 0.021 +/- 0.016, which are in agreement with the Standard Model predictions of A(c)(ll)= 0.0064 +/- 0.0003 and A(c)(tt)= 0.0111 +/- 0.0004.
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| 40. |
- Abulaiti, Yiming, et al.
(författare)
-
Measurements of W(+/-)Z production cross sections in pp collisions at root s=8 TeV with the ATLAS detector and limits on anomalous gauge boson self-couplings
- 2016
-
Ingår i: Physical Review D. - : American Physical Society. - 2470-0010. ; 93:9
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents measurements of W(+/-)Z production in pp collisions at a center-of-mass energy of 8 TeV. The gauge bosons are reconstructed using their leptonic decay modes into electrons and muons. The data were collected in 2012 by the ATLAS experiment at the Large Hadron Collider and correspond to an integrated luminosity of 20.3 fb(-1). The measured inclusive cross section in the detector fiducial region is sigma W(+/-)Z -> l'nu ll = 35.1 +/- 0.9(stat) +/- 0.8(sys) +/- 0.8(lumi) fb, for one leptonic decay channel. In comparison, the next-to-leading-order Standard Model expectation is 30.0 +/- 2.1 fb. Cross sections for W(+)Z and W(-)Z production and their ratio are presented as well as differential cross sections for several kinematic observables. Limits on anomalous triple gauge boson couplings are derived from the transverse mass spectrum of the W(+/-)Z system. From the analysis of events with a W and a Z boson associated with two or more forward jets an upper limit at 95% confidence level on the W(+/-)Z scattering cross section of 0.63 fb, for each leptonic decay channel, is established, while the Standard Model prediction at next-to-leading order is 0.13 +/- 0.01 fb. Limits on anomalous quartic gauge boson couplings are also extracted.
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| 41. |
- Abulaiti, Yiming, et al.
(författare)
-
Muon reconstruction performance of the ATLAS detector in proton-proton collision data at root s=13 TeV
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:5
-
Tidskriftsartikel (refereegranskat)abstract
- This article documents the performance of the ATLAS muon identification and reconstruction using the LHC dataset recorded at root s = 13 TeVin 2015. Using a large sample of J/.psi -> mu mu and Z -> mu mu decays from 3.2 fb(-1) of pp collision data, measurements of the reconstruction efficiency, as well as of the momentum scale and resolution, are presented and compared to Monte Carlo simulations. The reconstruction efficiency is measured to be close to 99 % over most of the covered phase space (vertical bar eta vertical bar < 2.5 and 5 < p(T) < 100 GeV). The isolation efficiency varies between 93 and 100 % depending on the selection applied and on the momentum of the muon. Both efficiencies are well reproduced in simulation. In the central region of the detector, the momentum resolution is measured to be 1.7 % (2.3 %) for muons from J/psi -> mu mu(Z -> mu mu) decays, and the momentum scale is known with an uncertainty of 0.05 %. In the region vertical bar eta vertical bar > 2.2, the p(T) resolution for muons from Z -> mu decays is 2.9 % while the precision of the momentum scale for low-p(T) muons from J/psi -> mu mu decays is about 0.2 %.
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| 42. |
- Abulaiti, Yiming, et al.
(författare)
-
Performance of algorithms that reconstruct missing transverse momentum in root s=8 TeV proton-proton collisions in the ATLAS detector
- 2017
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:4
-
Tidskriftsartikel (refereegranskat)abstract
- The reconstruction and calibration algorithms used to calculate missing transverse momentum (E-T(miss)) with the ATLAS detector exploit energy deposits in the calorimeter and tracks reconstructed in the inner detector as well as the muon spectrometer. Various strategies are used to suppress effects arising from additional proton-proton interactions, called pileup, concurrent with the hard-scatter processes. Tracking information is used to distinguish contributions from the pileup interactions using their vertex separation along the beam axis. The performance of the E-T(miss) reconstruction algorithms, especially with respect to the amount of pileup, is evaluated using data collected in proton-proton collisions at a centre-of-mass energy of 8 TeV during 2012, and results are shown for a data sample corresponding to an integrated luminosity of 20.3 fb(-1). The simulation and modelling of E-T(miss) in events containing a Z boson decaying to two charged leptons (electrons or muons) or a W boson decaying to a charged lepton and a neutrino are compared to data. The acceptance for different event topologies, with and without high transverse momentum neutrinos, is shown for a range of threshold criteria for E-T(miss), and estimates of the systematic uncertainties in the E-T(miss) measurements are presented.
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| 43. |
- Abulaiti, Yiming, et al.
(författare)
-
Performance of pile-up mitigation techniques for jets in pp collisions at root s=8 TeV using the ATLAS detector
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:11
-
Tidskriftsartikel (refereegranskat)abstract
- The large rate of multiple simultaneous protonproton interactions, or pile-up, generated by the Large Hadron Collider in Run 1 required the development of many new techniques to mitigate the adverse effects of these conditions. This paper describes the methods employed in the ATLAS experiment to correct for the impact of pile-up on jet energy and jet shapes, and for the presence of spurious additional jets, with a primary focus on the large 20.3 fb(-1) data sample collected at a centre-of-mass energy of root s = 8 TeV. The energy correction techniques that incorporate sophisticated estimates of the average pile-up energy density and tracking information are presented. Jet-to-vertex association techniques are discussed and projections of performance for the future are considered. Lastly, the extension of these techniques to mitigate the effect of pile-up on jet shapes using subtraction and grooming procedures is presented.
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| 44. |
- Abulaiti, Yiming, et al.
(författare)
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Probing lepton flavour violation via neutrinoless tau -> 3 mu decays with the ATLAS detector
- 2016
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:5
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Tidskriftsartikel (refereegranskat)abstract
- This article presents the sensitivity of the ATLAS experiment to the lepton-flavour-violating decays of tau -> 3 mu. A method utilising the production of t leptons via W -> tau nu decays is used. This method is applied to the sample of 20.3 fb(-1) of pp collision data at a centre-of-mass energy of 8 TeV collected by the ATLAS experiment at the LHC in 2012. No event is observed passing the selection criteria, and the observed (expected) upper limit on the tau lepton branching fraction into three muons, Br(tau -> 3 mu), is 3.76 x 10(-7) (3.94 x 10(-7)) at 90 % confidence level.
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| 45. |
- Abulaiti, Yiming, et al.
(författare)
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Reconstruction of hadronic decay products of tau leptons with the ATLAS experiment
- 2016
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:5
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a new method of reconstructing the individual charged and neutral hadrons in tau decays with the ATLAS detector. The reconstructed hadrons are used to classify the decay mode and to calculate the visible four-momentum of reconstructed tau candidates, significantly improving the resolution with respect to the calibration in the existing tau reconstruction. The performance of the reconstruction algorithm is optimised and evaluated using simulation and validated using samples of Z -> tau tau and Z(-> mu mu)+jets events selected from proton-proton collisions at a centre-of-mass energy root s = 8 TeV, corresponding to an integrated luminosity of 5 fb(-1).
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| 46. |
- Abulaiti, Yiming, et al.
(författare)
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Search for a high-mass Higgs boson decaying to a W boson pair in pp collisions at root s=8TeV with the ATLAS detector
- 2016
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Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :1
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Tidskriftsartikel (refereegranskat)abstract
- A search for a high-mass Higgs boson H is performed in the H -> WW -> l nu l nu and H -> WW -> l nu qq decay channels using pp collision data corresponding to an integrated luminosity of 20.3 fb(-1) collected at root s = 8TeV by the ATLAS detector at the Large Hadron Collider. No evidence of a high-mass Higgs boson is found. Limits on sigma(H) x BR(H -> WW) as a function of the Higgs boson mass m(H) are determined in three different scenarios: one in which the heavy Higgs boson has a narrow width compared to the experimental resolution, one for a width increasing with the boson mass and modeled by the complex-pole scheme following the same behavior as in the Standard Model, and one for intermediate widths. The upper range of the search is m(H) = 1500 GeV for the narrow-width scenario and m(H) = 1000 GeV for the other two scenarios. The lower edge of the search range is 200{300 GeV and depends on the analysis channel and search scenario. For each signal interpretation, individual and combined limits from the two WW decay channels are presented. At m(H) = 1500 GeV, the highest-mass point tested, sigma(H) x BR(H -> WW) for a narrow-width Higgs boson is constrained to be less than 22 fb and 6.6 fb at 95% CL for the gluon fusion and vector-boson fusion production modes, respectively.
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| 47. |
- Abulaiti, Yiming, et al.
(författare)
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Search for anomalous couplings in the Wtb vertex from the measurement of double differential angular decay rates of single top quarks produced in the t-channel with the ATLAS detector
- 2016
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :4
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Tidskriftsartikel (refereegranskat)abstract
- The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t-channel constrains these parameters simultaneously. The analysis described in this paper uses 4.6 fb(-1) of proton-proton collision data at root s = 7 TeV collected with the ATLAS detector at the LHC. Two parameters are measured simultaneously in this analysis. The fraction f(1) of decays containing transversely polarised W bosons is measured to be 0.37 +/- 0.07 (stat. circle plus syst.). The phase delta_ between amplitudes for transversely and longitudinally polarised W bosons recoiling against lefthanded b-quarks is measured to be -0.014 pi +/- 0.036 pi (stat. circle plus syst.). The correlation in the measurement of these parameters is 0.15. These values result in two-dimensional limits at the 95% confidence level on the ratio of the complex coupling parameters g(R) and V-L, yielding R-e[g(R)/V-L] is an element of [-0.36; 0.10] and Im[g(R)/V-L] is an element of [-0.17; 0.23] with a correlation of 0.11. The results are in good agreement with the predictions of the Standard Model.
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| 48. |
- Abulaiti, Yiming, et al.
(författare)
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Search for charged Higgs bosons in the H-+/- -> tb decay channel in pp collisions at root s=8 TeV using the ATLAS detector
- 2016
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Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :3
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Tidskriftsartikel (refereegranskat)abstract
- Charged Higgs bosons heavier than the top quark and decaying via H-+/- -> tb are searched for in proton-proton collisions measured with the ATLAS experiment at root s = 8 TeV corresponding to an integrated luminosity of 20.3 fb(-1). The production of a charged Higgs boson in association with a top quark, gb -> tH(+/-), is explored in the mass range 200 to 600 GeV using multi-jet final states with one electron or muon. In order to separate the signal from the Standard Model background, analysis techniques combining several kinematic variables are employed. An excess of events above the background only hypothesis is observed across a wide mass range, amounting to up to 2.4 standard deviations. Upper limits are set on the gb -> tH(+/-) production cross section times the branching fraction BR(H-+/- -> tb). Additionally, the complementary s-channel production, qq' -> H-+/-, is investigated through a reinterpretation of W' -> tb searches in ATLAS. Final states with one electron or muon are relevant for H-+/- masses from 0.4 to 2.0 TeV, whereas the all-hadronic final state covers the range 1.5 to 3.0 TeV. In these search channels, no significant excesses from the predictions of the Standard Model are observed, and upper limits are placed on the qq' -> H-+/- production cross section times the branching fraction BR(H-+/- -> tb).
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| 49. |
- Abulaiti, Yiming, et al.
(författare)
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Search for dark matter produced in association with a Higgs boson decaying to two bottom quarks in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 1550-7998 .- 1550-2368. ; 93:7
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Tidskriftsartikel (refereegranskat)abstract
- This article reports on a search for dark matter pair production in association with a Higgs boson decaying to a pair of bottom quarks, using data from 20.3 fb(-1) of pp collisions at a center-of-mass energy of 8 TeV collected by the ATLAS detector at the LHC. The decay of the Higgs boson is reconstructed as a high-momentum b (b) over bar system with either a pair of small-radius jets, or a single large-radius jet with substructure. The observed data are found to be consistent with the expected Standard Model backgrounds. Model-independent upper limits are placed on the visible cross sections for events with a Higgs boson decaying into b (b) over bar and large missing transverse momentum with thresholds ranging from 150 to 400 GeV. Results are interpreted using a simplified model with a Z' gauge boson decaying into different Higgs bosons predicted in a two-Higgs-doublet model, of which the heavy pseudoscalar Higgs decays into a pair of dark matter particles. Exclusion limits are also presented for the mass scales of various effective field theory operators that describe the interaction between dark matter particles and the Higgs boson.
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| 50. |
- Abulaiti, Yiming, et al.
(författare)
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Search for direct top squark pair production in final states with two tau leptons in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:2
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Tidskriftsartikel (refereegranskat)abstract
- A search for direct pair production of the supersymmetric partner of the top quark, decaying via a scalar tau to a nearly massless gravitino, has been performed using 20 fb(-1) of proton-proton collision data at root s = 8 TeV. The data were collected by the ATLAS experiment at the LHC in 2012. Top squark candidates are searched for in events with either two hadronically decaying tau leptons, one hadronically decaying tau and one light lepton, or two light leptons. No significant excess over the Standard Model expectation is found. Exclusion limits at 95 % confidence level are set as a function of the top squark and scalar tau masses. Depending on the scalar tau mass, ranging from the 87 GeV LEP limit to the top squark mass, lower limits between 490 and 650 GeV are placed on the top squark mass within the model considered.
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