| 1. |
|
|
| 2. |
- He, Dandan, et al.
(författare)
-
Design of a Low Sidelobe Monopulse Array Antenna with Hybrid Feeding Structure
- 2019
-
Ingår i: 2019 International Symposium on Antennas and Propagation, ISAP 2019 - Proceedings.
-
Konferensbidrag (refereegranskat)abstract
- A low sidelobe monopulse array antenna with hybrid feeding structure is proposed. The array consists of four subarrays which employ 6 × 8 microstrip patch elements on the top layer. The feed network, which is hybrid feeding structure, is composed of 1-to-48 microstrip power dividers on the top layer, microstrip to groove gap waveguide transitions and a gap waveguide-based monopulse comparator. The microstrip unequal power dividers are compact to achieve unequal amplitude distribution. And the monopulse comparator based on groove gap waveguide has low insertion loss. Hence, the array antenna achieves low sidelobe and high efficiency. The array antenna is designed with size of 400 × 320 mm2. The simulated VSWR is less than 1.5 from 10.52 - 10.68 GHz, the simulated gain is 28.7 dBi at 10.6 GHz and the sidelobe level is less than -19 dB. The null depth in the difference pattern is less than -35 dB.
|
|
| 3. |
- Song, Dandan, et al.
(författare)
-
Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor
- 2021
-
Ingår i: Cancer Letters. - : Elsevier BV. - 0304-3835 .- 1872-7980. ; 506, s. 23-34
-
Tidskriftsartikel (refereegranskat)abstract
- The AP-1 member Fra-1 is overexpressed in TNBC and plays crucial roles in tumor progression and treatment resistance. In a previous large-scale screen, we identified PARP1 to be among 118 proteins that interact with endogenous chromatin-bound Fra-1 in TNBC cells. PARP1 inhibitor (olaparib) is currently in clinical use for treatment of BRCA-mutated TNBC breast cancer. Here, we demonstrate that the Fra-1-PARP1 interaction impacts the efficacy of olaparib treatment. We show that PARP1 interacts with and downregulates Fra-1, thereby reducing AP-1 transcriptional activity. Olaparib treatment, or silencing of PARP1, consequently, increases Fra-1 levels and enhances its transcriptional activity. Increased Fra-1 can have adverse effect, including treatment resistance. We also found that a large fraction of PARP1-regulated genes was dependent on Fra-1. We show that by inhibiting Fra-1/AP-1, non-BRCA-mutated TNBC cells can become sensitized to olaparib treatment. We identify that high PARP1 expression is indicative of a poor clinical outcome in breast cancer patients overall (P = 0.01), but not for HER-2 positive patients. In conclusion, by exploring the functionality of the Fra-1 and PARP1 interaction, we propose that targeting Fra-1 could serve as a combinatory therapeutic approach to improve olaparib treatment outcome for TNBC patients.
|
|
| 4. |
- Song, Dandan, et al.
(författare)
-
ER alpha and ER beta Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions
- 2022
-
Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- The two estrogen receptors ER alpha and ER beta are nuclear receptors that bind estrogen (E2) and function as ligand-inducible transcription factors. They are homologues and can form dimers with each other and bind to the same estrogen-response element motifs in the DNA. ER alpha drives breast cancer growth whereas ER beta has been reported to be anti-proliferative. However, they are rarely expressed in the same cells, and it is not fully investigated to which extent their functions are different because of inherent differences or because of different cellular context. To dissect their similarities and differences, we here generated a novel estrogen-dependent cell model where ER alpha homodimers can be directly compared to ER beta homodimers within the identical cellular context. By using CRISPR-cas9 to delete ER alpha in breast cancer MCF7 cells with Tet-Off-inducible ER beta expression, we generated MCF7 cells that express ER beta but not ER alpha. MCF7 (ER beta only) cells exhibited regulation of estrogen-responsive targets in a ligand-dependent manner. We demonstrated that either ER was required for MCF7 proliferation, but while E2 increased proliferation via ER alpha, it reduced proliferation through a G2/M arrest via ER beta. The two ERs also impacted migration differently. In absence of ligand, ER beta increased migration, but upon E2 treatment, ER beta reduced migration. E2 via ER alpha, on the other hand, had no significant impact on migration. RNA sequencing revealed that E2 regulated a transcriptome of around 800 genes via each receptor, but over half were specific for either ER alpha or ER beta (417 and 503 genes, respectively). Functional gene ontology enrichment analysis reinforced that E2 regulated cell proliferation in opposite directions depending on the ER, and that ER beta specifically impacted extracellular matrix organization. We corroborated that ER beta bound to cis-regulatory chromatin of its unique proposed migration-related direct targets ANXA9 and TFAP2C. In conclusion, we demonstrate that within the same cellular context, the two ERs regulate cell proliferation in the opposite manner, impact migration differently, and each receptor also regulates a distinct set of target genes in response to E2. The developed cell model provides a novel and valuable resource to further complement the mechanistic understanding of the two different ER isoforms.
|
|
| 5. |
- Wang, Enlin, et al.
(författare)
-
Wideband High-Gain Circularly Polarized Antenna Array on Gap Waveguide for 5G applications
- 2019
-
Ingår i: 2019 International Symposium on Antennas and Propagation, ISAP 2019 - Proceedings.
-
Konferensbidrag (refereegranskat)abstract
- A wideband circularly polarized (CP) antenna array based on gap waveguide (GW) is presented in this paper. Firstly, a CP antenna based on septum polarizer is designed as the element for the array. Secondly, the feeding network is composed of T-junctions and realized by ridge gap waveguide (RGW). Then a 16 × 16 antenna array is built up by the elements. The novelty of this antenna is the combination of planar array and septum polarizer based on GW technology to achieve circularly polarization, high gain and high efficiency in wide bandwidth. The proposed array antenna achieves wide impedance bandwidth of 34.5% with the reflection coefficient below -10 dB, and a wide 3-dB axial ratio (AR) bandwidth of 26.5%. The simulated gain is higher than 32 dBic from 24.5 to 32.0 GHz, and the antenna efficiency is larger than 90%.
|
|
| 6. |
- Xing, Guozhong, et al.
(författare)
-
Correlated d(0) ferromagnetism and photoluminescence in undoped ZnO nanowires
- 2010
-
Ingår i: APPLIED PHYSICS LETTERS. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 96:11, s. 112511-
-
Tidskriftsartikel (refereegranskat)abstract
- We report the correlated d(0) ferromagnetism and photoluminescence in undoped single-crystalline ZnO nanowires synthesized by using a vapor transport method. We systematically tune the oxygen deficiency in the ZnO nanowires from 4% to 20% by adjusting the growth conditions, i.e., selecting different catalyst (Au or Ag) and varying the growth temperature. Our study suggests that oxygen vacancies induce characteristic photoluminescence and significantly boost the room-temperature ferromagnetism. Such undoped ZnO nanowires with tunable magnetic and optical properties are promising to find applications in multifunctional spintronic and photonic nanodevices.
|
|
| 7. |
- Zhao, Yuxuan, et al.
(författare)
-
Design of Wideband Dual-Circularly Polarized Endfire Antenna Array on Gap Waveguide
- 2019
-
Ingår i: 13th European Conference on Antennas and Propagation, EuCAP 2019.
-
Konferensbidrag (refereegranskat)abstract
- A wideband dual-circularly polarized (CP) linear antenna array is presented in this paper. Firstly, a dual-CP endfire antenna based on septum polarizer is designed as the element for the array. Secondly, the feeding network is realized by ridge gap waveguide. Then a 1×8 linear antenna array is built up by the elements. The proposed array antenna achieves wide impedance bandwidth of 44.6% with the reflection coefficient below -10 dB, the isolation between ports greater than 15 dB, and a wide 3-dB axial ratio (AR) bandwidth of 46.2%.
|
|
| 8. |
- Zhou, Guang-Quan, et al.
(författare)
-
Automatic Myotendinous Junction Identification in Ultrasound Images Based on Junction-Based Template Measurements
- 2023
-
Ingår i: IEEE transactions on neural systems and rehabilitation engineering. - : Institute of Electrical and Electronics Engineers (IEEE). - 1534-4320 .- 1558-0210. ; 31, s. 851-862
-
Tidskriftsartikel (refereegranskat)abstract
- Tracking the myotendinous junction (MTJ) motion in consecutive ultrasound images is essential to assess muscle and tendon interaction and understand the mechanics' muscle-tendon unit and its pathological conditions during motion. However, the inherent speckle noises and ambiguous boundaries deter the reliable identification of MTJ, thus restricting their usage in human motion analysis. This study advances a fully automatic displacement measurement method for MTJ using prior shape knowledge on the Y-shape MTJ, precluding the influence of irregular and complicated hyperechoic structures in muscular ultrasound images. Our proposed method first adopts the junction candidate points using a combined measure of Hessian matrix and phase congruency, followed by a hierarchical clustering technique to refine the candidates approximating the position of the MTJ. Then, based on the prior knowledge of Y-shape MTJ, we finally identify the best matching junction points according to intensity distributions and directions of their branches using multiscale Gaussian templates and a Kalman filter. We evaluated our proposed method using the ultrasound scans of the gastrocnemius from 8 young, healthy volunteers. Our results present more consistent with the manual method in the MTJ tracking method than existing optical flow tracking methods, suggesting its potential in facilitating muscle and tendon function examinations with in vivo ultrasound imaging.
|
|
