| 1. |
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| 2. |
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| 3. |
- Wang, Yilin, et al.
(författare)
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Microsphere-based antibody assays for human parvovirus B19V, CMV and T. gondii
- 2016
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Ingår i: BMC Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- Background: Human parvovirus B19 (B19V), cytomegalovirus (CMV) and Toxoplasma gondii (T. gondii) may cause intrauterine infections with potentially severe consequences to the fetus. Current serodiagnosis of these infections is based on detection of antibodies most often by EIA and individually for each pathogen. We developed singleplex and multiplex microsphere-based Suspension Immuno Assays (SIAs) for the simultaneous detection of IgG antibodies against B19V, CMV and T. gondii. Methods: We tested the performances of SIAs as compared to in-house and commercial reference assays using serum samples from well-characterized cohorts. Results: The IgG SIAs for CMV and T. gondii showed good concordance with the corresponding Vidas serodiagnostics. The B19V IgG SIA detected IgG in all samples collected >10 days after onset of symptoms and showed high concordance with EIAs (in-house and Biotrin). The serodiagnostics for these three pathogens performed well in multiplex format. Conclusions: We developed singleplex and multiplex IgG SIAs for the detection of anti-B19V,-CMV and -T. gondii antibodies. The SIAs were highly sensitive and specific, and had a wide dynamic range. These components thus should be suitable for construction of a multiplex test for antibody screening during pregnancy.
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| 4. |
- Alemrajabi, Mahmood, 1989-, et al.
(författare)
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Separation of Rare-Earth Elements Using Supported Liquid Membrane Extraction in Pilot Scale
- 2022
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Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 0888-5885 .- 1520-5045.
-
Tidskriftsartikel (refereegranskat)abstract
- The use of supported liquid membrane extraction for recovery and separation of rare-earth elements (REEs) has been investigated. Experiments have been carried out using the different configurations: (1) standard hollow fiber supported liquid membrane operation (HFSLM), (2) renewal liquid membrane operation (HFRLM), and (3) emulsion pertraction technology (EPT). The experiments were performed in pilot scale using a hollow fiber module with a mass transfer surface area of 8 m2. Synthetic feed solution was used with compositions based on a process for recovery of REE from an apatite concentrate. The total concentration of REE in the feed was varied from 1 to 22 mM REE and the pH was varied in the range 1.5–3.2. Di(2-ethylhexyl) phosphoric acid (D2HEPA) diluted in kerosene, 10% (v/v), was used as the organic membrane solution, and 3 M HCl was used as stripping solution. In supported liquid membrane extraction, the extraction performance is governed by both the kinetics of REE transport through the membrane and by thermodynamics. The effect of feed composition on the selectivity and transport of REE through the liquid membrane have been investigated. The results show that the liquid membrane is more selective toward the heavy REE at lower pH values and higher REE concentration. HFRLM shows a higher transport rate than HFSLM, while the HFSLM configuration gives a higher selectivity toward individual REE. The membrane performance in HFSLM configuration rapidly decays with time, while in the HFRLM and EPT configurations, the performance is much more stable. Possible mechanisms for decaying membrane performance are discussed, and gel formation is identified as being of significant importance. Gel formation is observed at an organic loading above ∼46% for Nd, 38% for Y, 46% for Dy, and 65% for Er. The work performed in this study serves as an initial step to demonstrate that HFRLM and EPT can provide stable operation and be feasible options for processing of REE liquors. A process flow diagram for the recovery of the REE, present in the apatite concentrate, in three fractions is proposed based on the results from this study.
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| 5. |
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| 6. |
- Andersson, Bo, Docent, 1965-, et al.
(författare)
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Developing M-Services : Lessons Learned From the Developers Perspective.
- 2007
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Ingår i: Communications of the Association for Information Systems. - : Association for Information Systems. - 1529-3181. ; 20:38, s. 605-620
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Tidskriftsartikel (refereegranskat)abstract
- In recent years the Swedish Police Force (SPF) have encountered greater demands on availability and 24/7 services when dealing with errands that are regarded as low priority compared to regular police work, e.g. collecting tips from the public. One attempt to meet these increasing demands was the development of a mobile communications platform that allowed the public to communicate easily with the SPF using their own mobile phones by sending SMS and MMS. The focus of this paper is on the early phases of development of this m-service, in particular, on the specific technical issues such as interoperability and standards used by the actors on the scene affecting the development of mobile information systems. The learning experiences are as follows: First, mobile communication platforms have a large potential for contributing to the field of emergency management information systems since they can be based on open and nationally accepted standards. Second, global and national standards for sending multimedia messages are not always truly standardized. Operators and mobile phone manufacturers make minor alterations and interpretations of the standard and thereby some of the benefits found in standards disappear. Third, when developing mobile information systems we suggest and recommend that the analysis phase should be enhanced compared to traditional system development, and it should address the interoperability between mobile phones on one hand and operators on the other hand.
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| 7. |
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| 8. |
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| 9. |
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| 10. |
- Andersson, Bo, Docent, 1965-, et al.
(författare)
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Issues in the Development of a Mobile based Communication Platform for the Swedish Police Force and Appointed Security Guards
- 2006
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Ingår i: In proceedings of the 3rd Conference on Information Systems for Crisis Response and Management (ISCRAM). - : Royal Flemish Academy of Belgium. - 9789090206011 ; , s. 181-187
-
Konferensbidrag (refereegranskat)abstract
- This paper presents the learning experiences from the development of a mobile-based communication platform, called OrdningsVaktsCentralen (OVC). OVC can be translated to Security Guard Central. OVC is designed to enable the Swedish Police Force (SPF) to comply with new legal requirements and enhance their collaboration with Appointed Security Guards (ASG). The focus of this paper is on the early phases of development; in particular on the specific technical issues such as interoperability and standards used in the development of mobile based systems. The learning experiences are as follows: firstly, when developing mobile based systems we suggest and recommend that the analysis phase should be enhanced and it should address the interoperability between mobile phones on one hand and operators on the other hand. Secondly, global and national standards, such as the MMS7 for sending multi-media messages, are not always standardized. It seems that operators and mobile phone manufacturers make minor alterations and interpretations of the standard and thereby some of the benefits found in standards disappear. Thirdly, mobile based communication platforms have a large potential for contributing to the field of emergency management information systems since they can be based on open and nationally accepted standards.
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| 11. |
- Andersson, Bo, et al.
(författare)
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Selection method for COTS systems
- 2014
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Ingår i: Procedia Technology. - : Elsevier BV. - 2212-0173. ; 16, s. 301-309, s. 301-309
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Tidskriftsartikel (refereegranskat)abstract
- Historically, organizations developed their information systems in-house. Today, a large portion of information systems development is based on the acquisition of pre-made information systems, so-called commercially off-the-shelf (COTS) systems. This approach for developing information systems requires new skills and methods supporting the process of evaluating and selecting information systems. This paper presents a method for selecting COTS systems. The method includes the following phases: problem framing, requirements and appraisal, and selection of systems. The idea and distinguishing feature behind the method is that improved understanding of organizational ‘ends’ or goals should govern the selection of a COTS system. This can also be expressed as a match or fit between ‘ends’ (e.g. improved organizational effectiveness) and ‘means’ (e.g. implementing COTS systems). This way of approaching the selection of COTS systems as viewing them as a ‘means’ to reach organizational ‘ends’ is different from the mainstream views of information systems development, namely the view that sees information systems development as a problem-solving process, and the underlying ontological view in other COTS selection methods, which focus on selection of functionality not reaching organizational ends.
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| 12. |
- Andersson, Bo, et al.
(författare)
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The Adoption of Advanced Mobile Services
- 2007
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Ingår i: Expanding the Knowledge Economy: Issues, Applications, Case Studies. Volume 4, Part 1.. - : IOS Press. - 9781586038014 ; , s. 1508-1514
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 13. |
- Andersson, Bo, Docent, 1965-, et al.
(författare)
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The Adoption of Advanced Mobile Services
- 2007
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Ingår i: Expanding the Knowledge Economy. - The Hauge, Netherlands : IOS Press. - 9781586038014
-
Konferensbidrag (refereegranskat)abstract
- From a diffusion and innovation perspective, the use of advanced mobileservices is limited, immature, and unsophisticated in several Swedish businessorganizations. In this paper, we report the result from a survey of the 20 out of the 50largest business corporations in Sweden. A number of factors explain the currentsituation, e.g. the mobile phone operators current business models, the lack ofservice providers working between the user organisations and the operators,difficulties in integrating mobile phones with other systems, and a generation issuewhere managers perceive advanced mobile service as a teenage thing.
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| 14. |
- Andersson, Martin, et al.
(författare)
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Thin film metal sensors in fusion bonded glass chips for high-pressure microfluidics
- 2017
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Ingår i: Journal of Micromechanics and Microengineering. - : IOP Publishing. - 0960-1317 .- 1361-6439. ; 27:1
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Tidskriftsartikel (refereegranskat)abstract
- High-pressure microfluidics offers fast analyses of thermodynamic parameters for compressed process solvents. However, microfluidic platforms handling highly compressible supercritical CO2 are difficult to control, and on-chip sensing would offer added control of the devices. Therefore, there is a need to integrate sensors into highly pressure tolerant glass chips. In this paper, thin film Pt sensors were embedded in shallow etched trenches in a glass wafer that was bonded with another glass wafer having microfluidic channels. The devices having sensors integrated into the flow channels sustained pressures up to 220 bar, typical for the operation of supercritical CO2. No leakage from the devices could be found. Integrated temperature sensors were capable of measuring local decompression cooling effects and integrated calorimetric sensors measured flow velocities over the range 0.5-13.8 mm/s. By this, a better control of high-pressure microfluidic platforms has been achieved.
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| 15. |
- Apanasevic, Tatjana, 1976-
(författare)
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Challenges Related to the Introduction of Innovative Services in the Market : Mobile Payment Services in the Swedish Retail Industry
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Mobile payment services are expected to be the next step of the electronic payment evolution. However, the level of penetration in European countries is lower than expected. The focus of most academic research has been in two main areas: (i) mobile payment adoption by consumers and (ii) technical aspects of the service. Consequently, a number of themes remain under-researched. In order to expand knowledge on reasons that affect the wider penetration of mobile payments, challenges related to the introduction of mobile payment services in the market have been explored in this thesis.More specifically, this research has addressed two problem areas: (i) why mobile payments have not been widely adopted by merchants; and (ii) what effects that the introduction of mobile payments has had on the business networks of the involved actors. As an example, we use the mobile payment services applied in the Swedish retail industry. The study is focused on the main groups of stakeholders – the mobile payment providers, the retailers, and the consumers.First, this study has helped to identify what different stakeholders expect of mobile payments and how these services correspond to their needs. In order to analyse the expectations of stakeholders, we have developed an analysis framework based on the theory of diffusion of innovations, the Technology Acceptance Model (TAM), and the theory of network externalities. The analysis highlights the expectations of stakeholders and helps to understand what kind of mobile payment service merchants expect and are willing to adopt. One key finding is that existing mobile payment services for retailing could be further improved in order to ensure an enhanced purchasing process for consumers.Second, the research has explored the impact of mobile payment services on the business networks. In order to analyse the relationships and cooperation between business actors, and changes in business strategy and network structure, we used the approach proposed by the Industrial Marketing and Purchasing (IMP) Group. The performed analysis illustrates the following changes in the structure of business networks for the traditional payment solutions (bank cards): (i) emergence of new business actors (i.e. independent mobile payment providers); (ii) new roles and activities of business actors; and (iii) exclusion of traditional business actors (i.e. banks) from the mobile payment systems.All these changes lead to increased complexity of relationships and increased level of interdependence between business actors within the networks. The following changes in the strategies of involved actors have been identified: (i) mobile payment providers seek to achieve a control over the business network; (ii) the retailers affect strategies of the mobile payment providers; (iii) the marketing strategies of business actors include cross-marketing in different sectors. All these changes result in additional value and enhanced quality of service for consumers.In order to analyse a complex and multidisciplinary area such as mobile payments, it is beneficial to use more than one analysis approach. A combination of different complementing methods helps to explore different aspects of the phenomenon and provides a more comprehensive overview of several research aspects.This work contributes to the academic research of mobile payment service adoption by merchants through proposing a theoretical analysis framework. More specifically, the research addresses a new area – expectations of retailers when new solutions are introduced. The framework consists of the following criteria and aspects: technological feasibility, economic benefits, lower service costs, added value of services, network externalities and the problem of critical mass, and finally, ease of use. This framework helps to identify what merchants can expect of mobile payment services.Another area of contribution is the analysis of the effect that mobile payments make on the actors and business networks of traditional payment services. The introduction of new services results in emergence of new business actors, a need to establish new relationships, and increased complexity of a business network. Moreover, in order to succeed, cooperation between all network actors is needed. As a result, business actors have to adjust their services and strategies according to needs of others.
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| 16. |
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| 17. |
- Backman, Helena, et al.
(författare)
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Lung function trajectories and associated mortality among adults with and without airway obstruction
- 2023
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Ingår i: American Journal of Respiratory and Critical Care Medicine. - : American Thoracic Society. - 1073-449X .- 1535-4970. ; 208:10, s. 1063-1074
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Spirometry is essential for diagnosis and assessment of prognosis in COPD.Objectives: To identify FEV1 trajectories and their determinants, based on annual spirometry measurements among individuals with and without airway obstruction. Furthermore, to assess mortality in relation to trajectories.Methods: In 2002-04, individuals with airway obstruction (AO) (FEV1/VC<0.70, n=993) and age- and sex-matched non-obstructive (NO) referents were recruited from population-based cohorts. Annual spirometries until 2014 were utilized in joint-survival Latent Class Mixed Models to identify lung function trajectories. Mortality data were collected during 15 years of follow-up.Results: Three trajectories were identified among the AO-cases and two among the NO referents. Trajectory membership was driven by baseline FEV1%predicted (%pred) in both groups and additionaly, pack-years in AO and current smoking in NO. Longitudinal FEV1%pred level depended on baseline FEV1%pred, pack-years and obesity. The trajectories were distributed: 79.6% T1AO FEV1-high with normal decline, 12.8% T2AO FEV1-high with rapid decline, and 7.7% T3AO FEV1-low with normal decline (mean 27, 72 and 26 mL/year) among AO-individuals, and 96.7% T1NO FEV1-high with normal decline and 3.3% T2NO FEV1-high with rapid decline (mean 34 and 173 mL/year) among referents. Hazard for death was increased for T2AO (HR1.56) and T3AO (HR3.45) vs. T1AO, and for T2NO (HR2.99) vs. T1NO.Conclusions: Three different FEV1 trajectories were identified among those with airway obstruction and two among the referents, with different outcomes in terms of FEV1-decline and mortality. The FEV1 trajectories among airway obstructive and the relationship between low FVC and trajectory outcome are of particular clinical interest.
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| 18. |
- Bergfelt, Andreas, et al.
(författare)
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ε-Caprolactone-based solid polymer electrolytes for lithium-ion batteries : synthesis, electrochemical characterization and mechanical stabilization by block copolymerization
- 2018
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 8:30, s. 16716-16725
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Tidskriftsartikel (refereegranskat)abstract
- In this work, three types of polymers based on epsilon-caprolactone have been synthesized: poly(epsilon-caprolactone), polystyrene-poly(epsilon-caprolactone), and polystyrene-poly(epsilon-caprolactone-r-trimethylene carbonate) (SCT), where the polystyrene block was introduced to improve the electrochemical and mechanical performance of the material. Solid polymer electrolytes (SPEs) were produced by blending the polymers with 10-40 wt% lithium bis(trifluoromethane) sulfonimide (LiTFSI). Battery devices were thereafter constructed to evaluate the cycling performance. The best performing battery half-cell utilized an SPE consisting of SCT and 17 wt% LiTFSI as both binder and electrolyte; a Li vertical bar SPE vertical bar LiFePO4 cell that cycled at 40 degrees C gave a discharge capacity of about 140 mA h g(-1) at C/5 for 100 cycles, which was superior to the other investigated electrolytes. Dynamic mechanical analysis (DMA) showed that the storage modulus E' was about 5 MPa for this electrolyte.
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| 19. |
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| 20. |
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| 21. |
- Bjureberg, Johan, et al.
(författare)
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Emotion regulation individual therapy for adolescents with nonsuicidal self-injury disorder : a feasibility study
- 2017
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Ingår i: BMC Psychiatry. - : Springer Nature. - 1471-244X. ; 17
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Nonsuicidal self-injury (NSSI) is a serious health risk behavior that forms the basis of a tentative diagnosis in DSM-5, NSSI Disorder (NSSID). To date, established treatments specific to NSSI or NSSID are scarce. As a first step in evaluating the feasibility, acceptability, and utility of a novel treatment for adolescents with NSSID, we conducted an open trial of emotion regulation individual therapy for adolescents (ERITA): a 12-week, behavioral treatment aimed at directly targeting both NSSI and its proposed underlying mechanism of emotion regulation difficulties.Methods: Seventeen girls (aged 13–17; mean = 15.31) with NSSID were enrolled in a study adopting an uncontrolled open trial design with self-report and clinician-rated assessments of NSSI and other self-destructive behaviors, emotion regulation difficulties, borderline personality features, and global functioning administered at pre-treatment, post-treatment, and 6-month follow-up. Measures of NSSI and emotion regulation difficulties were also administered weekly during treatment.Results: Ratings of treatment credibility and expectancy and the treatment completion rate (88%) were satisfactory, and both therapeutic alliance and treatment attendance were strong. Intent-to-treat analyses revealed significant improvements associated with large effect sizes in past-month NSSI frequency, emotion regulation difficulties, self-destructive behaviors, and global functioning, as well as a medium effect size in past-month NSSI versatility, from pre- to post-treatment. Further, all of these improvements were either maintained or further improved upon at 6-month follow-up. Finally, change in emotion regulation difficulties mediated improvements in NSSI over the course of treatment.Conclusions: Results suggest the acceptability, feasibility, and utility of this treatment for adolescents with NSSID.
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| 22. |
- Brew, Bronwyn K., et al.
(författare)
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Paediatric asthma and non-allergic comorbidities : A review of current risk and proposed mechanisms
- 2022
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Ingår i: Clinical and Experimental Allergy. - Stockholm : Wiley-Blackwell Publishing Inc.. - 0954-7894 .- 1365-2222. ; 15:9, s. 1035-1047
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Forskningsöversikt (refereegranskat)abstract
- It is increasingly recognized that children with asthma are at a higher risk of other non-allergic concurrent diseases than the non-asthma population. A plethora of recent research has reported on these comorbidities and progress has been made in understanding the mechanisms for comorbidity. The goal of this review was to assess the most recent evidence (2016-2021) on the extent of common comorbidities (obesity, depression and anxiety, neurodevelopmental disorders, sleep disorders and autoimmune diseases) and the latest mechanistic research, highlighting knowledge gaps requiring further investigation. We found that the majority of recent studies from around the world demonstrate that children with asthma are at an increased risk of having at least one of the studied comorbidities. A range of potential mechanisms were identified including common early life risk factors, common genetic factors, causal relationships, asthma medication and embryologic origins. Studies varied in their selection of population, asthma definition and outcome definitions. Next, steps in future studies should include using objective measures of asthma, such as lung function and immunological data, as well as investigating asthma phenotypes and endotypes. Larger complex genetic analyses are needed, including genome-wide association studies, gene expression-functional as well as pathway analyses or Mendelian randomization techniques; and identification of gene-environment interactions, such as epi-genetic studies or twin analyses, including omics and early life exposure data. Importantly, research should have relevance to clinical and public health translation including clinical practice, asthma management guidelines and intervention studies aimed at reducing comorbidities.
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| 23. |
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| 24. |
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| 25. |
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| 26. |
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| 27. |
- Carlsson, Sven, et al.
(författare)
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From ERP Systems to Enterprise Portals
- 2004
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Ingår i: The Enterprise Resource Planning Decade: Lessons Learned and Issues for the Future. ; , s. 263-287
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
- Carlsson, Sven, et al.
(författare)
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Model Curriculum for a Bachelor of Science Program in Business Information Systems Design (BISD 2007): Organisational Impacts
- 2009
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Ingår i: Information Systems Development: Challenges in Practice, Theory and Education Vol 1 2. - 9780387304038 ; , s. 781-793
-
Konferensbidrag (refereegranskat)abstract
- In the light of technological changes, changes in business contexts, decreased number of IS students, changes in educational systems, etc., IS education commentators have urged the IS community to develop new and alternative IS curricula. In response to this, we present a model curriculum for a Bachelor of Science program in business information systems design (BISD 2007). The curriculum has a strong design focus. Students should after completing the program have specified business information systems design capabilities; hence, the program is capabilities-driven. This chapter presents the general rationales for the program as well as the specific program design rationales. The program is presented with expected learning outcomes and how the students should be able to fulfil the outcomes. In addition, we discuss the organizational impacts of a new and innovative program.
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| 33. |
- Carlsson, Sven, et al.
(författare)
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Model Curriculum for a Bachelor of Science Program in Business Information Systems Design (BISD 2010)
- 2010
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Ingår i: Communication of the Association for Information Systems. ; 26, s. 525-546
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Tidskriftsartikel (refereegranskat)abstract
- Commentators on Information Systems (IS) education have urged the IS community to develop new and alternative IS curricula. The IS 2002 model curriculum has recently been revised. The new IS 2010 curriculum guidelines for undergraduate degree programs in Information Systems [Topi et al. 2010] has a curriculum structure to accommodate the education of several different professional roles within IS. This paper identifies one such role, the Business Information Systems Designer. It presents and argues for a new, integrated Bachelor of Science curriculum for Business Information Systems Design (BISD 2010) to educate for this role. The proposed curriculum focuses on the design and use of IS in business and has a strong design focus. The education focuses on developing and training a set of capabilities that enables the Business Information Systems Designer to participate in the design of business and IS in concert. Some examples of capabilities are communication and presentation skills, business and industry understanding, and high-level modeling. Consequently, the curriculum adopted a capabilities-driven pedagogical model in order to train specific skills. The paper presents the BISD 2010 with its specific expected learning outcomes, structure, and pedagogy, and also how the students should be able to fulfill the learning outcomes. The proposed curriculum differs from much of the current IS model curriculum discussions in a number of respects: (1) it is built on a notion of design, design science, and design as a profession, (2) it is based on a capability driven pedagogical model, (3) the curriculum is modeled for a European higher education context and the Bologna accord, and (4) it is not a model curriculum, but a specific, comprehensive, and ambitious curriculum for a degree program.
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| 34. |
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| 35. |
- Cornelissen, Gerard, et al.
(författare)
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Remediation of Contaminated Marine Sediment Using Thin-Layer Capping with Activated Carbon-A Field Experiment in Trondheim Harbor, Norway
- 2011
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 45:14, s. 6110-6116
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Tidskriftsartikel (refereegranskat)abstract
- In situ amendment of contaminated sediments using activated carbon (AC) is a recent remediation technique, where the strong sorption of contaminants to added AC reduces their release from sediments and uptake into organisms. The current study describes a marine underwater field pilot study in Trondheim harbor, Norway, in which powdered AC alone or in combination with sand or clay was tested as a thin-layer capping material for polycyclic aromatic hydrocarbon (PAH)-contaminated sediment. Several novel elements were included, such as measuring PAH fluxes, no active mixing of AC into the sediment, and the testing of new manners of placing a thin AC cap on sediment, such as AC+clay and AC+sand combinations. Innovative chemical and biological monitoring methods were deployed to test capping effectiveness. In situ sediment-to-water PAH fluxes were measured using recently developed benthic flux chambers. Compared to the reference field, AC capping reduced fluxes by a factor of 2-10. Pore water PAH concentration profiles were measured in situ using anew passive sampler technique, and yielded a reduction factor of 2-3 compared to the reference field. The benthic macrofauna composition and biodiversity were affected by the AC amendments, AC + clay having a lower impact on the benthic taxa than AC-only or AC + sand. In addition, AC + clay gave the highest AC recoveries (60% vs 30% for AC-only and AC + sand) and strongest reductions in sediment-to-water PAH fluxes and porewater concentrations. Thus, application of an AC-clay mixture is recommended as the optimal choice of the currently tested thin-layer capping methods for PAHs, and more research on optimizing its implementation is needed.
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| 36. |
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| 37. |
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| 38. |
- Granberg, Maria, et al.
(författare)
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Bioturbation-Driven Release of Organic Contaminants from Baltic Sea Sediments Mediated by the Invading Polychaete Marenzelleria neglecta.
- 2008
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 42:4, s. 1058-1065
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Tidskriftsartikel (refereegranskat)abstract
- Baltic Sea sediments are among the world’s most polluted regarding eutrophication and contamination. Eutrophication-induced hypoxia has caused depletion of bioturbating macrofauna in vast areas, producing laminated sediments. We investigated if reoxygenation and colonization by the invading deep-burrowing polychaete Marenzelleria neglecta may cause an augmented contaminant release from Baltic Sea sediments. Intact laminated sediment cores were exposed either to in situ hypoxia, reoxygenation, or reoxygenation combined with bioturbating M. neglecta. The release fluxes of particle-associated (NPart) and dissolved (NDiss) PCBs and chlorinated pesticide residues (POPs) were quantified (GC-ECD) after 85 d along with contaminant concentrations in sediment and biota. Lavoisier-based mass transfer coefficients (Kf) were calculated from NDiss. Sediment contaminant concentrations were high (ΣPCB7: 42–52 ng gsediment−1 dw) due to emissions from Stockholm. NDiss always exceeded NPart by an order of magnitude. Bioturbation enhanced NDiss and Kf from hypoxic sediments 0.7 – 3 times while reoxygenation alone had no significant effect. M. neglecta accumulated low amounts of contaminants but significantly stimulated aquatic release of bioavailable sequestered contaminants. Bioturbation should be included in aquatic contaminant fate models. We advise to consider quiescent pollutant sources and possible ecological shifts when aiming to restore eutrophicated aquatic environments.
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| 39. |
- Guo, Dongsheng, et al.
(författare)
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Perinuclear leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) as prognostic indicators in astrocytic tumors
- 2006
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 111:3, s. 238-346
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Tidskriftsartikel (refereegranskat)abstract
- We have previously characterized three human leucine-rich repeats and immunoglobulin-like domains (LRIG) genes and proteins, named LRIG1-3 and proposed that they may act as suppressors of tumor growth. The LRIG1 transmembrane protein antagonizes the activity of epidermal growth factor receptor family receptor tyrosine kinases. In this study, we evaluated the mRNA expression level of LRIG1-3 in human glioma cell lines and control-matched glioma tissues, characterized the sub-cellular localization of an LRIG3–GFP fusion protein, and analyzed the relationship between sub-cellular localization of LRIG1-3 and clinical parameters in 404 astrocytic tumors by immunohistochemistry. LRIG1-3 mRNA was detected in all human glioma cell lines and matched glioma samples, with large differences in the expression levels. Ectopically expressed LRIG3–GFP localized to perinuclear and cytoplasmic compartments, and to the cell surface of transfected glioma cells. Perinuclear staining of LRIG1-3 was associated with low WHO grade and better survival of the patients. Perinuclear staining of LRIG3 was associated with a lower proliferation index and was in addition to tumor grade, an independent prognostic factor. Furthermore, within the groups of grade III and grade IV tumors, perinuclear staining of LRIG3 significantly correlated with better survival. These results indicate that expression and sub-cellular localization of LRIG1-3 might be of importance in the pathogenesis and prognosis of astrocytic tumors.
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| 40. |
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| 41. |
- Hedman, Anna, et al.
(författare)
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Bidirectional relationship between eating disorders and autoimmune diseases
- 2019
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Ingår i: Journal of Child Psychology and Psychiatry. - Stockholm : Blackwell Publishing. - 0021-9630 .- 1469-7610. ; 60:7, s. 803-812
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases.METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs.RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED.CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses.
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| 42. |
- Hedman, Angelica, 1984-, et al.
(författare)
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Characterization of HPGe detectors using Computed Tomography
- 2015
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 785, s. 21-25
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Tidskriftsartikel (refereegranskat)abstract
- Computed Tomography (CT) high resolution imaging have been used to investigate if there is a significant change in the crystal-to-window distance, i.e. the air gap thickness, in a small n-type detector cooled to 77 K, and in a medium sized p-type HPGe detector when cooled to 100 K. The findings were compared to detector dimension data made available by the manufacturer. The air gap thickness increased by (0.38 +/- 0.07) mm for the n-type detector and by (0.40 +/- 0.15) mm for the p-type detector when the detectors were cooled to 77 resp. 100 K compared to at room temperature. Monte Carlo calculations indicate that these differences have a significant impact on the efficiency in close geometries (
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| 43. |
- Hedman, Christoffer, et al.
(författare)
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Hjälpa eller stjälpa?
- 2019
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Ingår i: Didaktisk utvecklingsdialog. - Lund : Studentlitteratur AB. - 9789144125749 ; , s. 85-102
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 44. |
- Hedman, Håkan, et al.
(författare)
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Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?
- 2002
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 41:4, s. 352-354
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Tidskriftsartikel (refereegranskat)abstract
- The LRIG1 gene (formerly LIG-1), recently cloned by us, displays structural similarities to the Drosophila Kek I gene. Kek I encodes a cell surface protein, Kekkon-1, which inhibits epidermal growth factor receptor-mediated signalling. We localized the LRIG1 gene to chromosome band 3p14.3, a region known to be deleted in various human cancers. In the present study LRIG1 gene expression was examined in different tumour cell lines and corresponding normal tissues by real-time RT-PCR. In many tumour cell lines, LRIG1 expression appeared absent or was down regulated compared to corresponding normal tissues. The results are consistent with LRIG1 being a tumour suppressor gene in humans. However, further studies are justified to elucidate the explicit role of LRIG1 as a negative regulator of oncogenesis.
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| 45. |
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| 46. |
- Hedman, Jonas, et al.
(författare)
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Analysing e-business models
- 2003
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Ingår i: Towards the Knowledge Society eCommerce, eBusiness and eGovernment. Second IFIP Conference on E-Commerce, E-Business, E-Government (13E 2002). - 1402072392 ; 105, s. 259-270
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Konferensbidrag (refereegranskat)abstract
- The business model concept is becoming increasingly popular within e-businesses and e-business research. However, the concept is often used relatively independently from theory, meaning model components and their interrelations are relatively obscure. This paper analysis three e-business models taxonomies based on a generic business model, which include customers and competitors, the offering, activities and organisation, resources and factor market interactions. The longitudinal processes and actions by which business models evolve are also included. The result of the analysis shows that most of the e-business models only addresses customers and the offering. Other important aspects of any business, e.g. activates and resource, are not addressed. In sum, e-business models, as they appear, in literature are formal descriptions of how businesses can use the Internet to leverage their offering, without any casual relationships between components, e.g. that the offering requires some activities to be performed by the organisation in order to deliver a offering to a market
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