| 1. |
- Andersson, Magnus, et al.
(författare)
-
CA AND PR SUBSTITUTION IN Y-BASED AND SM-BASED 1-2-3 COMPOUNDS
- 1993
-
Ingår i: Physical Review B Condensed Matter. - 0163-1829 .- 1095-3795. ; 48:10, s. 7590-7597
-
Tidskriftsartikel (refereegranskat)abstract
- Substitution with equal amounts of Ca and Pr has been studied mainly in Y- and Sm-based 1:2:3 samples and with some results also for Nd-based samples. Structural and chemical analysis and measurements of the superconducting T(c) and the upper critical magnetic field were performed. It was found that Ca and Pr can be dissolved in the orthorhombic structure up to about 25 at. % each in both Y- and Sm-based samples while for larger concentrations, only Pr continued to enter into the 1:2:3 structure. The depression of T(c) with Ca-Pr doping was found to be linear in concentration in contrast to the accelerated decrease in samples doped with only Pr. The rate of depression of T(c) increased in the sequence Y-, Sm-, and Nd-based hosts. The results suggest that Ca-Pr doping isolates a characteristic Pr-impurity effect in 1:2:3 samples. The critical magnetic-field slopes of Y- and Sm-based samples were almost independent of Ca-Pr content in the cosolubility region while a strong decrease was observed for larger Pr content, similar to 1:2:3 samples doped with Pr only. These results suggest an almost-temperature-independent magnetic pair-breaking effect by Pr.
|
|
| 2. |
|
|
| 3. |
- Andersson, Magnus, et al.
(författare)
-
STRUCTURAL AND SUPERCONDUCTING PROPERTIES OF Y1-2XCAXPRXBA2CU3O7-GAMMA
- 1992
-
Ingår i: Physica. C, Superconductivity. - 0921-4534 .- 1873-2143. ; 190:3, s. 255-260
-
Tidskriftsartikel (refereegranskat)abstract
- Samples of the nominal composition Y1-2xCaxPrxBa2Cu3O7-delta with 0 less-than-or-equal-to x less-than-or-equal-to 0.4 have been studied by X-ray diffraction techniques, chemical analyses, and measurements of the super conducting transition temperature and the upper critical magnetic field. For x less-than-or-equal-to 0.25, the results indicate that Ca and Pr can both replace Y in agreement with the nominal composition, while for x > 0.25 only Pr enters the orthorhombic unit cell. Compared to Pr substitution in 1:2:3 we observe small changes in the depression of T(c) and strong changes in the critical field slopes. These results suggest that if Pr has a magnetic pair-breaking effect, it is close to being temperature independent.
|
|
| 4. |
|
|
| 5. |
- Han, Shunhui, et al.
(författare)
-
Study of the upper critical magnetic field HC2 of YBA2CU3O7-DELTA compounds
- 1992
-
Ingår i: Solid State Communications. - 0038-1098 .- 1879-2766. ; 82:5, s. 379-380
-
Tidskriftsartikel (refereegranskat)abstract
- Careful resistive measurements of the upper critical field H(c2) have been made on high quality polycrystalline YBa2Cu3O7-delta samples in magnetic fields up to 12 T. The data have been fitted on the form H(c2) infinity (T(c)-T)alpha to compare with theoretical models. A cusp is found in the H(c2) (T) curve for both of the samples. Different exponents-alpha are obtained depending on the temperature range used in the fitting procedure.
|
|
| 6. |
|
|
| 7. |
- Hegedus, Csaba, et al.
(författare)
-
Redox control of cancer cell destruction
- 2018
-
Ingår i: Redox Biology. - : Elsevier BV. - 2213-2317. ; 16, s. 59-74
-
Tidskriftsartikel (refereegranskat)abstract
- Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and in the numerous cancer-related processes often point in different directions. In this review, we focus on the redox control mechanisms of tumor cell destruction. The review covers the tumor intrinsic role of oxidants derived from the reduction of oxygen and nitrogen in the control of tumor cell proliferation as well as the roles of oxidants and antioxidant systems in cancer cell death caused by traditional anticancer weapons (chemotherapeutic agents, radiotherapy, photodynamic therapy). Emphasis is also put on the role of oxidants and redox status in the outcome following interactions between cancer cells, cytotoxic lymphocytes and tumor infiltrating macrophages.
|
|
| 8. |
|
|
| 9. |
- Radeczky, Peter, et al.
(författare)
-
Bone-Specific Metastasis Pattern of Advanced-Stage Lung Adenocarcinoma According to the Localization of the Primary Tumor
- 2021
-
Ingår i: Pathology and Oncology Research. - : Frontiers Media SA. - 1219-4956 .- 1532-2807. ; 27
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Patients with advanced-stage lung adenocarcinoma (LADC) often develop distant metastases in the skeletal system. Yet, the bone-specific metastasis pattern is still controversial. We, therefore, aimed to examine how the primary tumor location affects bone specificity and survival in LADC patients diagnosed with skeletal metastases. Methods: In total, 209 bone-metastatic Caucasian LADC patients from two thoracic centers were included in this study. Focusing on the specific location of primary tumors and bone metastatic sites, clinicopathological variables were included in a common database and analyzed retrospectively. Skeletal metastases were diagnosed according to the contemporary diagnostic guidelines and confirmed by bone scintigraphy. Besides region- and side-specific localization, primary tumors were also classified as central or peripheral tumors based on their bronchoscopic visibility. Results: The most common sites for metastasis were the spine (n = 103) and the ribs (n = 60), followed by the pelvis (n = 36) and the femur (n = 22). Importantly, femoral (p = 0.022) and rib (p = 0.012) metastases were more frequently associated with peripheral tumors, whereas centrally located LADCs were associated with humeral metastases (p = 0.018). Moreover, we deduced that left-sided tumors give rise to skull metastases more often than right-sided primary tumors (p = 0.018). Of note, however, the localization of the primary tumor did not significantly influence the type of affected bones. Multivariate Cox regression analysis adjusted for clinical parameters demonstrated that central localization of the primary tumor was an independent negative prognostic factor for overall survival (OS). Additionally, as expected, both chemotherapy and bisphosphonate therapy conferred a significant benefit for OS. Conclusion: The present study demonstrates unique bone-specific metastasis patterns concerning primary tumor location. Peripherally located LADCs are associated with rib and femoral metastases and improved survival outcomes. Our findings might contribute to the development of individualized follow‐up strategies in bone-metastatic LADC patients and warrant further clinical investigations on a larger sample size.
|
|
| 10. |
- Sturniolo, Isotta, et al.
(författare)
-
PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype
- 2024
-
Ingår i: International Journal of Molecular Sciences. - 1661-6596. ; 25:7
-
Tidskriftsartikel (refereegranskat)abstract
- Cancers reprogram macrophages (MΦs) to a tumor-growth-promoting TAM (tumor-associated MΦ) phenotype that is similar to the anti-inflammatory M2 phenotype. Poly(ADP-ribose) polymerase (PARP) enzymes regulate various aspects of MΦ biology, but their role in the development of TAM phenotype has not yet been investigated. Here, we show that the multispectral PARP inhibitor (PARPi) PJ34 and the PARP14 specific inhibitor MCD113 suppress the expression of M2 marker genes in IL-4-polarized primary murine MΦs, in THP-1 monocytic human MΦs, and in primary human monocyte-derived MΦs. MΦs isolated from PARP14 knockout mice showed a limited ability to differentiate to M2 cells. In a murine model of TAM polarization (4T1 breast carcinoma cell supernatant transfer to primary MΦs) and in a human TAM model (spheroids formed from JIMT-1 breast carcinoma cells and THP-1-MΦs), both PARPis and the PARP14 KO phenotype caused weaker TAM polarization. Increased JIMT-1 cell apoptosis in co-culture spheroids treated with PARPis suggested reduced functional TAM reprogramming. Protein profiling arrays identified lipocalin-2, macrophage migration inhibitory factor, and plasminogen activator inhibitor-1 as potential (ADP-ribosyl)ation-dependent mediators of TAM differentiation. Our data suggest that PARP14 inhibition might be a viable anticancer strategy with a potential to boost anticancer immune responses by reprogramming TAMs.
|
|
| 11. |
- Tisza, Anna, et al.
(författare)
-
Laser ablation-inductively coupled plasma-mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma
- 2023
-
Ingår i: British Journal of Clinical Pharmacology. - 0306-5251. ; 89:11, s. 3364-3374
-
Tidskriftsartikel (refereegranskat)abstract
- Aims: Pleural mesothelioma (PM) is a highly aggressive thoracic tumour with poor prognosis. Although reduced tissue drug accumulation is one of the key features of platinum (Pt) resistance, little is known about Pt distribution in human PM. Methods: We assessed Pt levels of blood samples and surgically resected specimens from 25 PM patients who had received neoadjuvant Pt-based chemotherapy (CHT). Pt levels and tissue distributions were measured by laser ablation-inductively coupled plasma-mass spectrometry and correlated with clinicopathological features. Results: In surgically resected PM specimens, mean Pt levels of nontumourous (fibrotic) areas were significantly higher (vs tumourous regions, P = 0.0031). No major heterogeneity of Pt distribution was seen within the tumourous areas. Pt levels correlated neither with the microvessel area nor with apoptosis rate in the tumourous or nontumourous regions. A significant positive correlation was found between serum and both full tissue section and tumourous area mean Pt levels (r = 0.532, P = 0.006, 95% confidence interval [95% CI] 0.161-0.771 and r = 0.415, P = 0.039, 95% CI 0.011-0.702, respectively). Furthermore, a significant negative correlation was detected between serum Pt concentrations and elapsed time from the last cycle of CHT (r = −0.474, P = 0.017, 95% CI −0.738-−0.084). Serum Pt levels correlated negatively with overall survival (OS) (P = 0.029). Conclusions: There are major differences in drug distribution between tumourous and nontumourous areas of PM specimens. Serum Pt levels significantly correlate with full section and tumourous area average Pt levels, elapsed time from the last CHT cycle, and OS. Further studies investigating clinicopathological factors that modulate tissue Pt concentration and distribution are warranted.
|
|
