| 1. |
- Pfeiffer, Anne, et al.
(författare)
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Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
- 2016
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Ingår i: eLIFE. - : eLife Sciences. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- A major feature of embryogenesis is the specification of stem cell systems, but in contrast to the situation in most animals, plant stem cells remain quiescent until the postembryonic phase of development. Here, we dissect how light and metabolic signals are integrated to overcome stem cell dormancy at the shoot apical meristem. We show on the one hand that light is able to activate expression of the stem cell inducer WUSCHEL independently of photosynthesis and that this likely involves inter-regional cytokinin signaling. Metabolic signals, on the other hand, are transduced to the meristem through activation of the TARGET OF RAPAMYCIN (TOR) kinase. Surprisingly, TOR is also required for light signal dependent stem cell activation. Thus, the TOR kinase acts as a central integrator of light and metabolic signals and a key regulator of stem cell activation at the shoot apex.
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| 2. |
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| 3. |
- Olsson, Thomas, et al.
(författare)
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Sharing of Vulnerability Information among Companies : A Survey of Swedish Companies
- 2019
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Ingår i: 45th Euromicro Conference on Software Engineering and Advanced Applications. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781728132853 - 9781728134215 - 9781728134222 ; , s. 284-291
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Konferensbidrag (refereegranskat)abstract
- Software products are rarely developed from scratch and vulnerabilities in such products might reside in parts that are either open source software or provided by another organization. Hence, the total cybersecurity of a product often depends on cooperation, explicit or implicit, between several organizations. We study the attitudes and practices of companies in software ecosystems towards sharing vulnerability information. Furthermore, we compare these practices to contemporary cybersecurity recommendations. This is performed through a questionnaire-based qualitative survey. The questionnaire is divided into two parts: The providers' perspective and the acquirers' perspective. The results show that companies are willing to share information with each other regarding vulnerabilities. Sharing is not considered to be harmful neither to the cybersecurity nor their business, even though a majority of the respondents consider vulnerability information sensitive. However, the companies, despite being open to sharing, are less inclined to proactively sharing vulnerability information. Furthermore, the providers do not perceive that there is a large interest in vulnerability information from their customers. Hence, the companies' overall attitude to sharing vulnerability information is passive but open. In contrast, contemporary cybersecurity guidelines recommend active disclosure and sharing among actors in an ecosystem.
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| 4. |
- Rauch, Isabella, et al.
(författare)
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Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans
- 2007
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Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 51:11, s. 4167-4170
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Tidskriftsartikel (refereegranskat)abstract
- The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system.
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| 5. |
- Sartelli, Massimo, et al.
(författare)
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Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action
- 2023
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Ingår i: WORLD JOURNAL OF EMERGENCY SURGERY. - 1749-7922. ; 18:1
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Forskningsöversikt (refereegranskat)abstract
- Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or "golden rules," for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice.
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