| 1. |
- Liu, Dachuan, et al.
(författare)
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Amorphous iron-calcium phosphate-mediated biomineralized scaffolds for vascularized bone regeneration
- 2023
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Ingår i: Materials & design. - : Elsevier BV. - 0264-1275 .- 1873-4197. ; 235
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Tidskriftsartikel (refereegranskat)abstract
- Construction of organic–inorganic composites similar to natural bone in terms of structure and composition has attracted extensive attention. However, the clinical applications of these composites are limited due to the insufficient osteogenic and mechanical properties. In nature, the presence of amorphous iron-calcium phosphate (Fe-ACP) strengthens the mechanical properties of some biominerals, and our previous study has revealed its synthetic route and in vitro osteogenic properties. However, the potential role of Fe-ACP on biomineralization and constructing biomimetic scaffolds for bone regeneration has not been studied. Herein, a biomimetic scaffold with good osteogenic property was fabricated based on the mineralization of Fe-ACP, with the assistance of ice-templated freeze-casting. The in vitro study showed that the mineralized scaffolds possessed favorable biocompatibility and osteogenic property. Moreover, the scaffolds promoted cell chemotaxis and angiogenic property by upregulating the hypoxia inducible factor-1α (HIF-1α). In vivo experiment demonstrated potent early osteogenesis along with angiogenesis and ultimately promoted bone regeneration. Overall, the mineralized scaffold mediated by Fe-ACP precursors provide a unique platform to enhance bone tissue repair.
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| 2. |
- Wei, Daixiu, et al.
(författare)
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Novel Co-rich high entropy alloys with superior tensile properties
- 2019
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Ingår i: Materials Research Letters. - : Taylor & Francis. - 2166-3831. ; 7:2, s. 82-88
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Tidskriftsartikel (refereegranskat)abstract
- We developed a series of Co-rich CoxCr25(FeNi)(75-x) (x = 35, 45, 55, 65) high entropy alloys with improved strength and/or ductility, derived from lowering the stacking fault energy (SFE) and reducing the fcc phase stability of the equiatomic CoCrFeNi alloy. Thermodynamics and ab initio calculations demonstrated that increasing Co while decreasing Fe and Ni concentrations lower the SFE and reduce the fcc phase stability. The Co35Cr25Fe20Ni20 and Co45Cr25Fe15Ni15 alloys with single fcc phase, exhibit superior tensile properties, contributing to the twinning and fcc -> hcp martensitic transformation. The present study offers a guideline for designing high-performance high entropy alloys. [GRAPHICS] IMPACT STATEMENT A series of novel Co-rich non-equiatomic high entropy alloys with enhanced tensile properties were developed by lowering the stacking fault energy and reducing the phase stability of equiatomic CoCrFeNi alloy.
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