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1.	Henriksson, Eva, et al. (författare) Salt stress signalling and the role of calcium in the regulation of the Arabidopsis ATHB7 gene 2005 Ingår i: Plant, Cell and Environment. - : Wiley. - 0140-7791 .- 1365-3040. ; 28:2, s. 202-210 Tidskriftsartikel (refereegranskat)abstract In plants changes in cytosolic calcium ion concentrations ([Ca2+]cyt) have been detected after various stress treatments, including salt treatment. The involvement of a Ca2+ signal as an essential component of signalling pathways leading to downstream responses, such as gene expression, is supported only by a few studies. In this study the possible involvement of the salt stress-induced increase in [Ca2+]cyt in the signalling pathway leading to the induction of ATHB7, a homeobox gene encoding a homeodomain leucine zipper (HDZip) transcription factor was analysed. The salt-induced expression of ATHB7 was found to be independent of the Ca2+ signal evoked by salt. Instead, it was found that ATHB7 expression in shoots was not dependent on a direct contact with salt or osmoticum, whereas in roots, ATHB7 seemed to be induced by the direct contact, indicating that signals from roots cause systemic induction of ATHB7. Abscisic acid (ABA) or ABA-dependent components were found to, at least partly, to function as the systemic signal.
2.	Henriksson, Eva, et al. (författare) The HDZip class I genes ATHB5, -6 and -16 act redundantly to mediate light effects on hypocotyl elongation Annan publikation (populärvet., debatt m.m.)
3.	Wang, Yan, et al. (författare) The Arabidopsis homeobox gene, ATHB16, regulates leaf development and the sensitivity to photoperiod in Arabidopsis 2003 Ingår i: Developmental Biology. ; 264, s. 228-239 Tidskriftsartikel (refereegranskat)
4.	Wang, Yan, et al. (författare) The Arabidopsis homeobox gene, ATHB16, regulates leaf development and the sensitivity to photoperiod in Arabidopsis. 2003 Ingår i: Developmental Biology. - : Academic Press. ; 264, s. 228-239 Tidskriftsartikel (refereegranskat)
5.	Abarkan, Abdellah, et al. (författare) Corona hotar förvärra svenska bostadskrisen. 108 forskare: Sveriges regering och kommuner måste förhindra en katastrof. 2020 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)abstract Debattartikel och Öppet brev publicerad i tidningen Aftonbladet. 29.3. 2020.
6.	Almung, Magnus, et al. (författare) I solitärens skugga : Nyttobyggnadens kreativa restaurering 2015 Rapport (populärvet., debatt m.m.)abstract Ekonomibyggnader har alltid behövts för de huvudbyggnader som finns inom våra bevarade kulturmiljöer. Några nyttobyggnader uppskattas och används fortfarande, andra betraktas som problematiska överloppsbyggnader, många rivs. Alltför få har dokumenterats eller fått sin historia klarlagd vilket undanhållit viktig kunskap om samhällets framväxt. Vi vill synliggöra och betona vikten av att bevara och utveckla hela bebyggelsemiljöer, ofta med ett antal hus utöver huvudbyggnaden och tillhörande yttre miljö i staden eller på landet. Denna rapport visar kursdeltagarnas projektarbeten om nyttobyggnader. De har dokumenterat med traditionella och nya arbetsmetoder, inventerat och intervjuat, läst och besökt arkiv, värderat, analyserat och därefter föreslagit hur man ska ta hand om och utveckla nyttobyggnaderna i sina kulturmiljöer.
7.	Argyropoulos, Dimitris D. S., et al. (författare) Kraft Lignin: A Valuable, Sustainable Resource, Opportunities and Challenges 2023 Ingår i: ChemSusChem. - : John Wiley and Sons Inc. - 1864-5631 .- 1864-564X. ; 16:23 Forskningsöversikt (refereegranskat)abstract Kraft lignin, a by-product from the production of pulp, is currently incinerated in the recovery boiler during the chemical recovery cycle, generating valuable bioenergy and recycling inorganic chemicals to the pulping process operation. Removing lignin from the black liquor or its gasification lowers the recovery boiler load enabling increased pulp production. During the past ten years, lignin separation technologies have emerged and the interest of the research community to valorize this underutilized resource has been invigorated. The aim of this Review is to give (1) a dedicated overview of the kraft process with a focus on the lignin, (2) an overview of applications that are being developed, and (3) a techno-economic and life cycle asseeements of value chains from black liquor to different products. Overall, it is anticipated that this effort will inspire further work for developing and using kraft lignin as a commodity raw material for new applications undeniably promoting pivotal global sustainability concerns.
8.	Arver, Brita, et al. (författare) Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer: A National Survey. 2011 Ingår i: Annals of surgery. - : Lippincott Williams and Wilkins; 1999. - 1528-1140 .- 0003-4932. ; 253:6, s. 1147-1154 Tidskriftsartikel (refereegranskat)abstract BACKGROUND/OBJECTIVE:: This study attempted a national inventory of all bilateral prophylactic mastectomies performed in Sweden between 1995 and 2005 in high-risk women without a previous breast malignancy. The primary aim was to investigate the breast cancer incidence after surgery. Secondary aims were to describe the preoperative risk assessment, operation techniques, complications, histopathological findings, and regional differences. METHODS:: Geneticists, oncologists and surgeons performing prophylactic breast surgery were asked to identify all women eligible for inclusion in their region. The medical records were reviewed in each region and the data were analyzed centrally. The BOADICEA risk assessment model was used to calculate the number of expected/prevented breast cancers during the follow-up period. RESULTS:: A total of 223 women operated on in 8 hospitals were identified. During a mean follow-up of 6.6 years, no primary breast cancer was observed compared with 12 expected cases. However, 1 woman succumbed 9 years post mastectomy to widespread adenocarcinoma of uncertain origin. Median age at operation was 40 years. A total of 58% were BRCA1/2 mutation carriers. All but 3 women underwent breast reconstruction, 208 with implants and 12 with autologous tissue. Four small, unifocal, invasive cancers and 4 ductal carcinoma in situ were found in the mastectomy specimens. The incidence of nonbreast related complications was low (3%). Implant loss due to infection/necrosis occurred in 21 women (10%) but a majority received a new implant later. In total, 64% of the women underwent at least 1unanticipated secondary operation. CONCLUSIONS:: Bilateral prophylactic mastectomy is safe and efficacious in reducing future breast cancer in asymptomatic women at high risk. Unanticipated reoperations are common. Given the small number of patients centralization seems justified.
9.	Aspegren Kendall, Sally, 1950-, et al. (författare) A pilot study of body awareness programs in the treatment of fibromyalgia syndrome 2000 Ingår i: Arthritis Care and Research. - 0893-7524 .- 1529-0123. ; 13:5, s. 304-311 Tidskriftsartikel (refereegranskat)abstract Objective. To compare in a pilot study the effect of two physical therapies, the Mensendieck system (MS) and body awareness therapy (BAT) according to Roxendal, in fibromyalgia patients and to investigate differences in effect between the two interventions. Methods. Twenty female patients were randomized to either MS or BAT in a program lasting 20 weeks. Evaluations were tender point examination and questionnaires, including visual analog scales (pain intensity at worst site, muscular stiffness, evening fatigue, and global health), Fibromyalgia Impact Questionnaire (FIQ), Coping Strategies Questionnaire, Quality of Life Scales, Arthritis Self-Efficacy Scale (ASES), and disability before, immediately after, and at 6 and 18 months followup. Results. The BAT group had improved global health at 18 months followup, but lower results than the MS group. The MS group had improved FIQ, ASES other symptoms, and pain at worst site at 18 months followup. Conclusion. In the present pilot study, MS was associated with more positive changes than BAT.
10.	Bengtsson, Stefan, et al. (författare) Debatt : staten dränerar universiteten 2015 Ingår i: Dagens industri. - 0346-640X. ; :15 oktober Tidskriftsartikel (populärvet., debatt m.m.)
11.	Bergh, Jonas, et al. (författare) FACT : An Open-Label Randomized Phase III Study of Fulvestrant and Anastrozole in Combination Compared With Anastrozole Alone as First-Line Therapy for Patients With Receptor-Positive Postmenopausal Breast Cancer 2012 Ingår i: Journal of Clinical Oncology. - Alexandria, VA : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:16, s. 1919-1925 Tidskriftsartikel (refereegranskat)abstract Purpose: To compare the effect of therapy with anastrozole versus a combination of fulvestrant and anastrozole in women in first relapse of endocrine-responsive breast cancer. Patients and Methods: Postmenopausal women, or premenopausal women receiving a gonadotropin-releasing hormone agonist, with estrogen receptor– and/or progesterone receptor–positive disease at first relapse after primary treatment of localized disease were open-label randomly assigned to a fulvestrant loading dose (LD) regimen followed by monthly injection plus 1 mg of anastrozole daily or to 1 mg of anastrozole daily alone. The primary end point was time to progression (TTP). Results: In all, 514 women were randomly assigned to fulvestrant plus anastrozole (experimental arm; n = 258) or anastrozole (standard arm; n = 256). Approximately two thirds had received adjuvant antiestrogens, but only eight individuals had received an aromatase inhibitor. Median TTP was 10.8 and 10.2 months in the experimental versus standard arm, respectively (hazard ratio [HR] = 0.99; 95% CI, 0.81 to 1.20; P = .91); median overall survival was 37.8 and 38.2 months, respectively (HR = 1.0; 95% CI, 0.76 to 1.32; P = 1.00). Incidences of prespecified adverse events (AEs) were similar. Hot flashes were more common in the experimental arm: 63 patients (24.6%) versus 35 patients (13.8%) in the standard arm (P = .0023). Death owing to AEs was reported in 11 (4.3%) and five patients (2.0%) in the experimental versus standard arm, respectively. Conclusion: Fulvestrant (250 mg + LD regimen) in combination with anastrozole offered no clinical efficacy advantage over anastrozole monotherapy in this population of individuals with a relatively high proportion of previous adjuvant antiestrogen exposure.
12.	Bing, Vibeke, et al. (författare) Det har både blivit lättare och svårare - om det nya i att arbeta på familjecentraler 2011 Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 88:2, s. 133-143 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract Den här artikeln utgår ifrån personalens perspektiv. Första delen är resultat från en enkätstudie som fokuserar på hur personal förändrat sitt sätt att arbeta sedan de började arbeta på familjecentral. De flesta upplever att eftersom de har andra professioner i samma hus lättare upptäcker familjer med extra behov av stöd och bättre kan fokusera på sina egna arbetsuppgifter. Som fördjupning av svaren i enkäten har olika personalkategorier ombetts skriva en kortfattad berättelse om sitt eget arbete på familjecentral. Sjuksköterskor, barnmorska, psykolog, socionom, förskollärare, bibliotekarie och samordnare berättar hur de arbetar. Slutsatserna från artikeln är att familjecentraler kan ses som ett svar på att stödet till blivande och småbarnsföräldrar har utökats på de områden som den traditionella mödra- och barnhälsovården har sett som problematisk att möta. Sannolikt ökar förutsättningarna för att de som behöver extra stöd också kan få möjlighet till detta under förutsättning att extra stöd finns när familjecentralens resurser inte räcker till.
13.	Bing, Vibeke, et al. (författare) Det har både blivit lättare och svårare - om det nya i att arbeta på familjecentraler 2011 Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 88:2, s. 133-143 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract Den här artikeln utgår ifrån personalens perspektiv. Första delen är resultat från en enkätstudie som fokuserar på hur personal förändrat sitt sätt att arbeta sedan de började arbeta på familjecentral. De flesta upplever att eftersom de har andra professioner i samma hus lättare upptäcker familjer med extra behov av stöd och bättre kan fokusera på sina egna arbetsuppgifter. Som fördjupning av svaren i enkäten har olika personalkategorier ombetts skriva en kortfattad berättelse om sitt eget arbete på familjecentral. Sjuksköterskor, barnmorska, psykolog, socionom, förskollärare, bibliotekarie och samordnare berättar hur de arbetar. Slutsatserna från artikeln är att familjecentraler kan ses som ett svar på att stödet till blivande och småbarnsföräldrar har utökats på de områden som den traditionella mödra- och barnhälsovården har sett som problematisk att möta. Sannolikt ökar förutsättningarna för att de som behöver extra stöd också kan få möjlighet till detta under förutsättning att extra stöd finns när familjecentralens resurser inte räcker till.
14.	Brendle, Annika, et al. (författare) Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer ITGB4 as prognostic marker. 2008 Ingår i: Carcinogenesis. - : Oxford University Press. - 0143-3334 .- 1460-2180. ; 29:7, s. 1394-1399 Tidskriftsartikel (refereegranskat)abstract Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined the effect of single-nucleotide polymorphisms (SNPs) in predicted miRNA target sites of six integrin genes (ITGA3, ITGA6, ITGAv, ITGB3, ITGB4 and ITGB5) on breast cancer (BC) risk and clinical outcome. Six SNPs were genotyped in 749 Swedish incident BC cases with detailed clinical data and up to 15 years of follow-up together with 1493 matched controls. We evaluated associations between genotypes and BC risk and clinical tumour characteristics. Survival probabilities were compared between different subgroups. As a novel finding, several SNPs seemed to associate with the hormone receptor status. The strongest association was observed between the A allele of the SNP rs743554 in the ITGB4 gene and oestrogen receptor-negative tumours [odds ratio 2.09, 95% confidence intervals (CIs) 1.19-3.67]. The same SNP was associated with survival. The A allele carriers had a worse survival compared with the wild-type genotype carriers (hazard ratio 2.11, 95% CIs 1.21-3.68). The poor survival was significantly associated with the aggressive tumour characteristics: high grade, lymph node metastasis and high stage. None of the SNPs was significantly associated with BC risk. As the ITGB4 SNP seems to influence tumour aggressiveness and survival, it may have prognostic value in the clinic.
15.	Glimelius, Bengt, et al. (författare) U-CAN : a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. 2018 Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 57:2, s. 187-194 Tidskriftsartikel (refereegranskat)abstract Background: Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary clinical data, blood and tissue from cancer patients was therefore initiated in 2010 by Uppsala and Umeå Universities and involving their corresponding University Hospitals, which are referral centers for one third of the Swedish population.Material and Methods: Patients with cancer of selected types who are treated at one of the participating hospitals are eligible for inclusion. The healthcare-integrated sampling scheme encompasses clinical data, questionnaires, blood, fresh frozen and formalin-fixed paraffin-embedded tissue specimens, diagnostic slides and radiology bioimaging data.Results: In this ongoing effort, 12,265 patients with brain tumors, breast cancers, colorectal cancers, gynecological cancers, hematological malignancies, lung cancers, neuroendocrine tumors or prostate cancers have been included until the end of 2016. From the 6914 patients included during the first five years, 98% were sampled for blood at diagnosis, 83% had paraffin-embedded and 58% had fresh frozen tissues collected. For Uppsala County, 55% of all cancer patients were included in the cohort.Conclusions: Close collaboration between participating hospitals and universities enabled prospective, longitudinal biobanking of blood and tissues and collection of multidisciplinary clinical data from cancer patients in the U-CAN cohort. Here, we summarize the first five years of operations, present U-CAN as a highly valuable cohort that will contribute to enhanced cancer research and describe the procedures to access samples and data.
16.	Göhler, Stella, et al. (författare) Functional germline variants in driver genes of breast cancer 2017 Ingår i: Cancer Causes and Control. - Dordrecht : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 28:4, s. 259-271 Tidskriftsartikel (refereegranskat)abstract Purpose: Germline mutations in tumour suppressor genes cause various cancers. These genes are also somatically mutated in sporadic tumours. We hypothesized that there may also be cancer-related germline variants in the genes commonly mutated in sporadic breast tumours. Methods: After excluding the well-characterized breast cancer (BC) genes, we screened 15 novel genes consistently classified as BC driver genes in next-generation sequencing approaches for single nucleotide polymorphisms (SNPs). Altogether 40 SNPs located in the core promoter, 5′- and 3′-UTR or which were nonsynonymous SNPs were genotyped in 782 Swedish incident BC cases and 1,559 matched controls. After statistical analyses, further evaluations related to functional prediction and signatures of selection were performed. Results: TBX3 was associated with BC risk (rs2242442: OR = 0.76, 95% CI 0.64–0.92, dominant model) and with less aggressive tumour characteristics. An association with BC survival and aggressive tumour characteristics was detected for the genes ATR (rs2227928: HR = 1.63; 95% CI 1.00–2.64, dominant model), RUNX1 (rs17227210: HR = 3.50, 95% CI 1.42–8.61, recessive model) and TTN (rs2303838: HR = 2.36; 95% CI 1.04–5.39; rs2042996: HR = 2.28; 95% CI 1.19–4.37, recessive model). According to the experimental ENCODE data all these SNPs themselves or SNPs in high linkage disequilibrium with them (r2 ≥ 0.80) were located in regulatory regions. RUNX1 and TTN showed also several signatures of positive selection. Conclusion: The study gave evidence that germline variants in BC driver genes may have impact on BC risk and/or survival. Future studies could discover further germline variants in known or so far unknown driver genes which contribute to cancer development.
17.	Göhler, Stella, et al. (författare) Impact of functional germline variants and a deletion polymorphism in APOBEC3A and APOBEC3B on breast cancer risk and survival in a Swedish study population 2016 Ingår i: Journal of Cancer Research and Clinical Oncology. - : Springer. - 0171-5216 .- 1432-1335. ; 142:1, s. 273-276 Tidskriftsartikel (refereegranskat)abstract Purpose: The C -> T mutation signature caused by APOBEC family members contributes to the development of breast cancer (BC). Also overexpression of APOBEC3B and a similar to 29. 5-kb deletion polymorphism between APOBEC3A and APOBEC3B have been associated with increased BC risk. Methods: We investigated in a population-based study, with 782 Swedish BC cases and 1559 controls, associations between potentially functional germline variants in APOBEC3A or APOBEC3B gene and BC risk and survival. Additionally, we identified deletion polymorphism carriers and explored possible associations with BC. Results: No evidence of association between any germline variant, including the deletion polymorphism, and BC risk or survival was observed. Only APOBEC3A promoter polymorphism rs5757402 was associated with low stage (OR = 0.69, 95 % CI 0.50-0.96, dominant model). Conclusion: The reported association between the deletion polymorphism and BC risk was not confirmed in the Swedish population, nor did any genotyped germline variant show any association with BC risk or survival.
18.	Hamrin, Kerstin, et al. (författare) Microdialysis in human skeletal muscle : effects of adding a colloid to the perfusate. 2002 Ingår i: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 92:1, s. 385-93 Tidskriftsartikel (refereegranskat)abstract Microdialysis catheters (CMA-60 with a polyamide dialysis membrane; 20,000-molecular wt cutoff) were either immersed in an external medium or were inserted in the quadriceps femoris muscle of healthy subjects, using perfusate with or without dextran 70. Varying the position of the outflow tubing induced changes in hydrostatic pressure. The sample volumes were significantly smaller in catheters perfused without a colloid compared with those perfused with a colloid [11-50% (in vitro) and 8-59% (in vivo) lower than in colloid-perfused catheters with the same position of the outflow tubing]. The sample volumes were also significantly smaller when the dialysis membrane was influenced by maximal hydrostatic pressure (above position) compared with minimal hydrostatic pressure (below position) [7-38% (in vitro) and 3-46% (in vivo) lower than in catheters in the below position with the same perfusion fluid]. In vivo, glucose concentration at a perfusion flow rate of 0.33 microl/min was higher when the catheters were perfused without a colloid [18-28% higher than in colloid-perfused catheters with the same position of the outflow tubing (P < 0.001)] than with a colloid. A corresponding difference also tended to occur with lactate, glycerol, and urea. At 0.16 microl/min, the glucose concentration was the same irrespective of whether fluid loss had been counteracted by colloid inclusion or by lowering of outlet tubing. The mechanism behind the observed concentration difference is thought to be a higher effective perfusion flow rate when fluid loss is prevented at low-perfusion flows. This study shows that fluid imbalances can have important implications for microdialysis results at low-perfusion flow rates.
19.	Hamrin, Kerstin, et al. (författare) Prolonged Exercise-Induced Stimulation of Skeletal Muscle Glucose Uptake Is due to Sustained Increases in Tissue Perfusion and Fractional Glucose Extraction 2011 Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 96:4, s. 1085-1092 Tidskriftsartikel (refereegranskat)abstract Context: The mechanisms behind the positive effects of physical activity on glucose metabolism in skeletal muscle and the time course of the effects need to be more elucidated. Objective: The aim was to examine the prolonged effects of an acute bout of one-legged exercise on local skeletal muscle glucose utilization and tissue perfusion. Design and Setting: Interstitial glucose concentration, local tissue perfusion, glucose uptake, and effects of insulin infusion were studied 12 h after an acute bout of exercise and without prior exercise. Participants: Ten healthy subjects, five women and five men, participated in the study. Intervention: Microdialysis measurements, (133)Xe clearance, and a 2-h hyperinsulinemic euglycemic clamp were performed on two occasions. Main Outcome Measures: We measured interstitial glucose concentration and tissue perfusion in the quadriceps femoris muscle of both legs. Results: Tissue perfusion (3.3 +/- 0.6 ml x 100 g(-1) x min(-1) vs. 1.4 +/- 0.2 ml x 100 g(-1) x min(-1); P = 0.007) and basal glucose uptake (2.3 +/- 0.5 mu mol x 100 g(-1) x min(-1) vs. 0.9 +/- 0.2 mu mol x 100 g(-1) x min(-1); P = 0.006) were increased in the leg that had exercised compared to the resting leg; the findings in the resting leg were comparable to those in the control experiment without prior exercise. The relative effect of insulin on fractional skeletal muscle glucose uptake was the same in all experimental settings, and insulin did not affect tissue perfusion. Conclusions: The prolonged stimulatory effect of physical exercise on skeletal muscle glucose uptake was mediated via vascular effects combined with an increase in basal glucose transport independent of enhancement of insulin responses.
20.	Henriksson, Fredrik, 1988-, et al. (författare) An outlook on multi material body solutions in the automotive industry – possibilities and manufacturing challenges 2016 Ingår i: SAE Technical Paper Series. - Detroit (MI), USA : Society of Automotive Engineers. - 0148-7191. Konferensbidrag (refereegranskat)abstract In the automotive industry, mass reduction and lightweight design is a continuing trend that does not show signs of declining. When looking at where to reduce weight in a vehicle, the body is a preferential subsystem due to its large contribution to overall mass and the stability of body composition over a specific model range. The automotive industry of today moves toward a greater differentiation in materials that compose a car, which can be seen in the several different multi material vehicle bodies that have been introduced by manufacturers in recent years. But while mixing materials may contribute to a good compromise between weight reduction and vehicle cost, it also proposes a number of challenges that need to be addressed. Among other material factors, the different coefficients of thermal expansions might introduce new stresses during painting and curing. Joining processes and possible chemical reactions between materials also needs to be taken into account, the same with the question of whether to integrate or differentiate different functions in a system. If the manufacturing plant uses mixed model assembly lines, design of end effectors for gripping multiple different materials is another challenge not previously encountered in this context. In this paper, a number of production and manufacturing related challenges are discussed, and the authors highlight different areas where the requirements of design engineering tools needs to be evaluated for these new multi material concepts and design decisions in order for automotive manufacturers to ensure future market competitiveness.
21.	Henriksson, Fredrik, et al. (författare) Challenges when working with renewable materials: knocking on wood? 2021 Ingår i: International Journal of Sustainable Engineering. - : Taylor & Francis. - 1939-7038 .- 1939-7046. ; 14:6, s. 1980-1987 Tidskriftsartikel (refereegranskat)abstract With sustainable design as a vital strategical component for companies competing on the market today, many companies will need to transition to a use of sustainable and/or renewable materials in the near future. But how can this be done, and what can be done to bridge the gap from current affairs to a new, more sustainable state? Looking towards industries with experience might help making the first step just a little bit easier. This study aims to find challenges and bottlenecks when working with sustainable materials, in order to help companies interested in transitioning towards using sustainable or renewable materials in their products. The paper describes an interview study with five Swedish wood industry companies, differentiated in size and products, where the authors identify several key findings for both industry (already working with wood or aiming at transitioning towards renewable materials) and academia (on using renewable materials, need for further research, and pointers for teaching design and engineering students). Findings range from how organisational culture affects material selection, to how flexibility and efficiency effects automation solutions via how these companies have approached outsourcing of parts of their production.
22.	Henriksson, Fredrik, 1988-, et al. (författare) Including Student Case Projects in Integrated Product and Production Development Research – Methodology Description and Discussion 2016 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract Within integrated product and production development research, casestudies needto be performed for data gathering purposes. Today, there are two commonly used ways to perform this research; observingindustry projects orhaving the researchers perform the projects themselves. The first option can pose data access and IPRissues, and the second optioncomes with biasing risks. Another approach is to work with studentcaseprojects, givingstudents interesting projects and findinga solution to mediate both data gathering opportunity and biasing risks. This approach has been tested at Linköping University, with students performing projects in the Vinnovafunded Production 2030 –Large Scale Production in Mixed Materials project. Two larger student case projects have been performed on the topic of material substitution and mixed material solutions within the automotive industry.In this paper, the method used to include student projects is presented along with identified benefits and drawbacks. Including student case projects in research have shown to be beneficial in research on processes, projects and methodology, but needs to be complemented by data fromindustry projects and the researcher ́s own work within integrated product and production development in order to create a more reliable analysis with high level of detail.
23.	Henriksson, Fredrik, 1988-, et al. (författare) Integrated Product and Production Research on Introducing Internet of Things in Swedish Wood Industry Products 2018 Ingår i: Procedia Manufacturing. - : Elsevier. - 2351-9789. ; 25, s. 10-16 Tidskriftsartikel (refereegranskat)abstract To enable transitioning the Swedish economy into a bioeconomy, Swedish wood industry need to increase added value and introduce new products to market by introducing new technology and improving the product and production development processes. Research in automotive industry have shown the need for integrating product and production development when introducing new technology in existing production systems, and have indicated a possibility of using specifically designed student case projects in order to generate qualitative data. In this paper, one student case project on product and production development in the Swedish wood industry, involving IoT wood products, is presented and evaluated.
24.	Henriksson, Fredrik, 1988- (författare) Introducing New Materials in the Automotive Industry : Managing the Complexity of Introducing New Materials in Existing Production Systems 2017 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract Passenger vehicles are central to Western society, and contribute to a signiﬁcant part of our greenhouse gas emissions. In order to reduce emissions, the automotive industry as a whole is working to reduce mass in passenger vehicles in order to reduce energy consumption. One way to reduce mass is to introduce lightweight materials in the body of the vehicle. This research aims to explore the relationship between product and production system when introducing new materials.Besides a theoretical review and an industry-centered technological mapping, four case studies have been conducted during the course of this licentiate thesis. Two case studies were conducted with engineering design students working as development teams, one case study with the author as the developer and ﬁnally one case study in an industrial environment at a product owning company with in-house production. The goal of the case studies has been to increase the collective knowledge of how product development decisions affect production development decisions, and vice versa, when developing passenger vehicles in new materials.In the following analysis of case study outcomes, a number of factors important for introducing new materials are discussed. The relationship between product and production is investigated, both in terms of how the production system affects the product and how the product affects the production system. The outcome from this analysis is a mapping of important factors for automotive industry companies to understand and identify when looking at introducing new materials in existing production systems. Finally, a suggestion for future research efforts is presented.
25.	Henriksson, Fredrik, 1988- (författare) On Material selection and its consequences in product development 2021 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Technological development, and increased demands on sustainable solutions, have impacted the development of new products. New products need to be more efficient, and there are increased possibilities for a more diversified and informed decision regarding what materials are used in the product. However, how can engineers and designers be helped in their efforts to make better decisions regarding materials?In this research, carried out via multiple case studies and action research, behaviors regarding material selection and material management are examined. The data has been collected using participation action research, observations, and interviews as the primary sources of information. The author has conducted participation action research integrated into an industrial environment, multiple case studies using students in industrial design engineering have been done, and the researcher has performed interview studies with industry representatives. The behaviors described in the empirical studies are contrasted with basic decision theory and analysis of established product development methodology, asking the questions: Are basic assumptions built into models and methods taught to designers and engineers valid?The research presented in this thesis shows that there are personal, technical, and organizational aspects to selecting and managing materials in product development. This work has also shown that assuming rationality, something that is built into methods and models as well as taught to engineering students, is not valid in decision-making; human beings are not rational, and entirely rational decisions are not possible due to the vast data and prediction needs to be able to make entirely rational decisions. Even when assuming some variant of bounded rationality, multiple factors described in decision theory are not acknowledged in product development methodology. Two of these can be described as identity (both personal and professional) and mental models of materials.The discrepancy in how decisions are described in decision theory and how methods for decision-making are designed in product development risks inhibit the introduction of new and more sustainable materials in products. This could be because non-rational aspects of decision-making are incorporated in the decision-making under the assumption of rationality. It could also be because of the mental models of materials affecting what the designers and engineers think they can do with a particular material. These behaviors make the risks of introducing new materials too big for a designer or engineer to accept.Outcomes from this research show that additional data will not be enough to persuade designers and engineers to select new material to its fullest extent. This can slow down sustainability improvements in products. To counter this, it is suggested that the personal and non-rational side of decision-making is acknowledged and valued, that visions and ideology are used to encourage the introduction of new materials rather than relying on technical or economic aspects, and that designers and engineers are encouraged and enabled to take higher risks and evaluate more “unknown” parameters.To fully implement these suggestions, the following three things need to happen:A: Design and engineering education needs to teach students how to have more flexible mental models of materialsB: Industry should find ways for designers and engineers to experiment further and learn (both on an organizational and personal level)C: Academia should further investigate how behaviors, mental models and habits affect product development and design work, especially regarding material selection and material management.
26.	Henriksson, Fredrik, 1988-, et al. (författare) On Material Substitution in Automotive BIWs – From Steel to Aluminum Body Sides 2016 Ingår i: 26th CIRP Design Conference. - : Elsevier. ; , s. 683-688 Konferensbidrag (refereegranskat)abstract Weight reduction and material substitution are increasing trends in the automotive industry. In this project, the task of substituting the steel body side in the monocoque of a large SUV towards an aluminum body side was investigated through a design engineering approach adopting a breadth-first analysis method. One conclusion based on the analysis is that the choice of joining technology would become arbitrary due to the breadth-first approach. In this paper, the authors present their findings from the aforementioned case, including the challenges with switching between materials with fundamentally different properties when performing material substitution projects. The possibility of having taken a depth-first analysis approach, and the possible effects on the project result, is discussed.
27.	Henriksson, Fredrik, 1988-, et al. (författare) Product development in the Swedish Automotive industry: Can design tools be viewed as decision support systems? 2015 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract Design engineers working in the automotive industry have to take many design decisions, based on numerous diverse criteria. This results in a high workload of complex decisions. One way to reduce decision complexity and improve decisions could be to improve design tools. Decision support systems (DSSs) have been used in a managerial context to improve decisions. In this article, the authors assess whether design tools generally can be viewed as DSSs. A combination of literature review, surveys and qualitative interviews with seven design engineers was used to assess whether current design tools function as decision supports in product development. Although the specific design context needs to be considered, this study’s results suggest that design tools can generally function as DSSs. In future work, the adaptability to different problem solving patterns needs further in-depth research in the form of individual studies for specific tools in specific contexts.
28.	Henriksson, Fredrik, 1988-, et al. (författare) Student-developed laboratory exercises - An approach to cross-disciplinary peer education 2016 Ingår i: Proceedings of NordDesign 2016. - : The Design Society. - 9781904670803 - 9781904670810 ; , s. 226-235 Konferensbidrag (refereegranskat)abstract With new technologies and demands from industry, universities need to adapt in order to educate engineers suited for the job market of tomorrow. Focusing on the fields of product development and mechanical engineering, topics such as new lightweight materials and lightweight designs are currently a focus of many industries, and the demand from industry is that engineers graduating should have some knowledge in these fields. In this case, a project was set up for a student-developed laboratory exercise in lightweight material, focusing on the interconnection between material properties, geometry and manufacturing technology in order to fulfil a contextual requirement. The industry chosen was the aircraft industry, due to its heavy emphasis on light weight. The chosen component (a civil aircraft radome) meant that material properties not necessarily connected to high specific strength became important, something that adds educational value to the exercise. Since the introduction of the exercise, the plan is to introduce the laboratory exercise in more courses where the interdisciplinary connections between material properties, geometry and manufacturing technology needs to be explained for students as well as evaluate how this approach to exercise development can be improved and further utilized. This paper presents the learnings from setting up the laboratory exercise, as well as discusses the possibilities of thesis works as an enabler for peer education and puts these in a context for a future, adaptive engineering education that quickly can add or renew material in the curriculum without substantial investment of resources.
29.	Henriksson, Fredrik, 1988-, et al. (författare) Towards Applying The Boothroyd, Dewhurst and Knight Methodology for Cost Estimation on Fibre Composite Manufacturing - A Theoretical Approach 2014 Ingår i: Proceedings of The 6th International Swedish Production Symposium 2014. - Gothenburg. - 9789198097412 Konferensbidrag (refereegranskat)abstract Increased usage of carbon fibre composite poses challenges for the automotive industry; one is to manage carbon fibre composites within the product development process. This paper combines knowledge in design engineering, material science and production technology, aiming to bridge these domains. The study indicates that mass production methods suitable for carbon fibre have several factors in common with traditional polymer production methods. Thus, it is possible that DfMA methods for traditional polymer production can be adjusted for carbon fibre composite production. The result is summarised in a table aiming to facilitate engineering decisions related to cost estimations for composite moulding.
30.	Henriksson, Fredrik, 1988-, et al. (författare) University as a Laboratory : Exploring how engineering education can support industrial needs 2018 Ingår i: NordDesign 2018. - 9789176851852 Konferensbidrag (refereegranskat)abstract Universities have two major tasks; generating knowledge through research and educating students for academia, the public sector and the industry. In this paper, the authors explore how engineering education can support industrial needs on two fronts: creating a case study platform for research and preparing graduating engineering students to become more capable engineers when beginning their working life in industry, by applying the ""University as a laboratory"" concept. ""University as a laboratory"", as coined by Henriksson (2017), means that research-based case study projects are brought into educational courses where students are assigned to work as engineering designers, and researchers can observe problem solving patterns and evaluate different methodologies (also presented by Henriksson and Johansen (2016)). Though the concept have been presented earlier (Henriksson and Johansen 2016, Henriksson 2017), a more thorough evaluation is in order to further understand the effects of integrating research and education in the ""University as a laboratory"" concept. This is done through the performance and evaluation of a research-based engineering design education project in collaboration with automotive industrial partners; a project on lightweight and sustainable product and production development. The study evaluates three aspects of the project; the researchers' view, the teachers' view and the students' view. Data on all three aspects has been gathered through group interviews, observations and written assignments during the project, as well as interviews with participating students one year after the end of the project and workshops with researchers and teachers involved in the project. Analysis has been done on a qualitative basis, to investigate whether case projects are suitable for deep understanding in engineering fields and whether project courses are suitable to test different approaches of integrated product and production development.
31.	Henriksson, Mikael (författare) Arkeologiska förväntningar i mötet med ett landskap : Stenålderns Blekinge ur ett kunskapsperspektiv 2019 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract This study is about archaeological knowledge production. It is also about what kind of impact such knowledge may have on an antiquarian/archaeological practice as well as on society as a whole. The work focuses broadly on Stone Age archaeology and specifically on the middle-Mesolithic Age in the county of Blekinge in the South East of Sweden.Until the late 1990’s, large-scale archaeological excavations in this region were rare. In particular, there were significant gaps in early- and middle-Mesolithic archaeology of other regions. In particular, the study brings up the relationship with the defined Kongemose culture's settlements in Southern Scandinavia. From a knowledge perspective the study discusses how different kinds of methodological practices are important for both archaeology and society, to be able to see and understand a more complete historical picture. Based on this, the focus shifts the role of museums within regional archaeology. The study here argues for a more strategically executed dissemination and presentation of archaeological knowledge towards different stakeholders.
32.	Henriksson, Pontus, et al. (författare) Body mass index and gestational weight gain in migrant women by birth regions compared with Swedish-born women : A registry linkage study of 0.5 million pregnancies 2020 Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:10 Tidskriftsartikel (refereegranskat)abstract INTRODUCTION: Women migrating to high-income countries may have increased risks of adverse pregnancy outcomes as compared with native-born women. However, little is known whether migrant women are more likely to have unhealthy body mass index (BMI) or gestational weight gain (GWG), which is of importance considering the well-established links between unhealthy BMI and GWG with adverse pregnancy outcomes. Hence, the aim of the study was to examine the prevalence and estimate odds ratios (ORs) of underweight and obesity in the first trimester as well as inadequate and excessive GWG across birth regions in migrant (first-generation) and Swedish-born women in a population-based sample of pregnant women in Sweden.METHODS: This population-based study included 535 609 pregnancies from the Swedish Pregnancy Register between the years 2010-2018. This register has a coverage of approximately 90% and includes data on body weight, height, birth country and educational attainment. BMI in the first trimester of pregnancy was classified as underweight, normal weight, overweight and obesity whereas GWG was classified as inadequate, adequate and excessive according to the recommendations from the National Academy of Medicine, USA. BMI and GWG were examined according to 7 birth regions and the 100 individual birth countries. Adjusted ORs of underweight, obesity as well as inadequate or excessive GWG by birth regions were estimated using multinomial logistic regression.RESULTS: There were large disparities in unhealthy BMI and GWG across birth regions. For instance, women born in North Africa and Middle East and Sub-Saharan Africa had 1.40 (95% CI 1.35-1.44) and 2.13 (95% CI 2.03-2.23) higher odds of obesity compared with women born in Sweden. However, women born in Sub-Saharan Africa had also considerably higher odds of underweight (OR, 2.93 [95% CI 2.70-3.18]) and inadequate GWG (OR, 1.97 [95% CI 1.87-2.07]). The limitations of the study include the lack of a validated measure of acculturation and that the study only had data on first-generation migration.CONCLUSIONS: The large differences across the 7 regions and 100 countries highlights the importance of considering birth region and country-specific risks of unhealthy BMI and GWG in first-generation migrant women. Furthermore, inadequate GWG was common among pregnant first-generation migrant women, especially in women born in Sub-Saharan Africa, which demonstrates the need to promote adequate GWG, not only the avoidance of excessive GWG. Thus, our findings also indicate that additional support and interventions may be needed for first-generation migrant women from certain birth regions and countries in order to tackle the observed disparities in unhealthy BMI and GWG. Although further studies are needed, our results are useful for identifying groups of women at increased risk of unhealthy BMI and weight gain during pregnancy.
33.	Henriksson, Pontus, et al. (författare) Self-Rated Health in Migrant and Non-Migrant Women before, during and after Pregnancy : A Population-Based Study of 0.5 Million Pregnancies from the Swedish Pregnancy Register 2020 Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 9:6 Tidskriftsartikel (refereegranskat)abstract Self-rated health is a strong health marker. Migrants have been suggested to have poorer self-rated health than non-migrants (i.e., native-born). However, little is known about whether there are disparities in self-reported health in relation to pregnancy. Therefore, the aim of the current study was to examine the odds of poor self-rated health before, during and after pregnancy in migrant women as compared to women born in Sweden. We utilized population-based data from the Swedish Pregnancy Register containing 0.5 million women born in Sweden (i.e., non-migrant women) and migrant women between 2010 and 2018. Self-rated health was reported on a 5-point scale (from very poor to very good). Very poor and poor health were categorized as poor self-rated health. Logistic regression was utilized to calculate odds ratios (ORs) that were unadjusted and adjusted for covariates (age, parity, educational attainment and body mass index). The results demonstrate disparities in self-rated health across birth regions. In comparison to women born in Sweden, women born in Latin America and the Caribbean, South Asia as well as North Africa and the Middle East had consistently higher odds of poor self-rated health before, during and after pregnancy (ORs ranging from 1.14 to 1.96 in both unadjusted and adjusted models). Although women born in Sub-Saharan Africa did have comparable self-rated health as to women born in Sweden before pregnancy, after accounting for covariates, they had lower odds of poor self-rated health during and after pregnancy (ORs: 0.71 and 0.80 respectively). Therefore, additional measures and support may be needed to tackle disparities in health between migrant and non-migrant women before, during and after pregnancy.
34.	Jedvert, Kerstin, 1984, et al. (författare) Mild steam explosion: A way to activate wood for enzymatic treatment, chemical pulping and biorefinery processes 2012 Ingår i: Nordic Pulp and Paper Research Journal. - 2000-0669 .- 0283-2631. ; 27:5, s. 828-835 Tidskriftsartikel (refereegranskat)abstract Industrially chipped wood chips of Norway spruce (Picea abies) were subjected to mild steam explosion (115 - 160 degrees C) in a small-scale steam explosion reactor. This was followed by kraft cooking or extraction in alkali at 130 degrees C for two hours, or by an enzymatic treatment with a culture filtrate in order to investigate the efficiency of the process in opening wood structure. The results demonstrated that mild explosion has an effect on opening wood structure, shown by increased release of glucomannans during alkaline extraction and faster delignification in kraft cooks for steam-exploded samples. The effect was also shown by analysis of the released reducing sugars of enzymatic treated wood chips, which showed that the wood structure became accessible for enzymes even at very modest mild steam explosion conditions. This was not observed in untreated wood chips, used as reference. The enzyme activity increased with increased temperature during mild steam explosion, and the effect did not seem to be linear. The mechanical effect of steam explosion seems to be of great importance at lower temperatures, and both chemical and mechanical effects are important at higher steam explosion temperatures. Samples for enzymatic treatment were taken both from the edges of wood chips as well as from the middle part of the chips, and the effect of steam explosion was somewhat greater in samples from the middle parts.
35.	Kehoe, Laura, et al. (författare) Make EU trade with Brazil sustainable 2019 Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
36.	Lebeda Henriksson, Charlotte (författare) Barns och ungdomars bilder av poliser : En studie i två lokala sammanhang 2015 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract SammanfattningI fokus för denna licentiatuppsats är barns och ungdomars bilder av poliser. Syftet är att beskriva dessa bilder och placera dem i en senmodern samhällelig kontext. Vägledande i beskrivningarna är tre meningsbärande begrepp – föreställningar, erfarenheter och förväntningar – vilka har utkristalliserats ur det empiriska materialet. Utgångspunkten är att bilderna är socialt konstruerade, med hänsyn till maktordning, habitus, sociala positioner och symboliskt kapital. För att förstå den betydelse unga tillskriver poliser är ansatsen därtill kulturellt sociologisk. Studien bygger på ett enkätmaterial med 1 945 barn och ungdomar utan specifik erfarenhet av kriminella handlingar, i åldern 10-22 år. 35 grundskolor och 11 gymnasieskolor har deltagit och svarsfrekvensen är 58 procent i vardera kommunen. Dessutom genomfördes samtalsintervjuer i grupp med sammanlagt 50 deltagare i direkt anslutning till enkätstudien. Analysmetoden är inspirerad av tematisk analys.Materialet visar att barns och ungdomars uppfattning om Polisen som institution är positiv, men att de är något mer kritiska till Polisen som organisation och betydligt mer kritiska till enskilda poliser. Den övervägande andelen av deltagarna har varit i kontakt med poliser, främst i skolan eller när de har ansökt om pass. Förväntningarna på poliser är att de ska rikta sin verksamhet mot vuxna. Den yngre gruppen, 10-12 år är i större utsträckning, positiva till poliser. Den något äldre gruppen, 13-16 år, är mer negativa, medan den äldsta gruppen, 17-22 år, har en betydligt mer nyanserad bild av poliser.Vidare visar det sig att föreställningar, erfarenheter och förväntningar intimt hänger samman. Föreställningar bygger på olika erfarenheter, vilket i sin tur genererar olika förväntningar mot bakgrund av olika förutsättningar i tillvaron. En del bilder är mer generellt förekommande medan andra framställs främst i mer avgränsade kategoriserade grupper med unga.Ungas bilder kan tolkas som en kamp inom fältet där habitus och symboliskt kapital utgör maktmedel. Om vi väljer att se på unga som seismografer kan deras bilder vara tecken på en allmänt hållen bild av poliser även bland vuxna. Det visar sig också finnas en mystik runt poliser. Samtidigt som de kan upplevas vara i vägen är det spännande att se dem agera i skarpt läge. Skrönor spär på mystiken samtidigt som Polisens sätt att vara förtegna om hur de verkar, bidrar till de bilder vi har av dem.
37.	Lei, Haixin, et al. (författare) PAI-1 -675 4G/5G polymorphism as a prognostic biomarker in breast cancer 2008 Ingår i: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 109:1, s. 165-175 Tidskriftsartikel (refereegranskat)abstract Extracellular matrix degradation, mediated by the urokinase plasminogen activation (uPA) system, is a critical step in tumor invasion and metastasis. High tumor levels of uPA and its inhibitor PAI-1 have been correlated with poor prognosis in breast cancer. We examined whether genetic variation in the genes of the uPA system affect breast cancer susceptibility and prognosis. We genotyped eight potentially functional single nucleotide polymorphisms (SNPs) in six genes of the uPA system in 959 Swedish breast cancer patients with detailed clinical data and up to 15 years of follow-up together with 952 matched controls. We used the unconditional logistic regression models to evaluate the associations between genotypes and breast cancer risk and tumor characteristics. The Kaplan-Meier method was used to estimate the survival probabilities; the log-rank test was used to test differences between subgroups. None of the SNPs conferred an increased breast cancer risk, but correlation with some traditional prognostic factors was observed for several SNPs. Most importantly, we identified the -675 4G/5G SNP in the PAI-1 gene as a promising prognostic biomarker for breast cancer. Compared to the 4G/4G and 4G/5G genotypes 5G/5G homozygosity correlated significantly with worse survival (RR 2.04, 95% CI 1.45-2.86, P<0.001), especially in patients with more aggressive tumors. 5G/5G homozygotes were also the group with worse survival among lymph node negative cases. Our finding suggests that genotyping PAI-1 -675 4G/5G may help in clinical prognosis of breast cancer.
38.	Lei, Haixin, et al. (författare) Single nucleotide polymorphisms in the DMBT1 promoter and the progression of breast cancer 2006 Ingår i: Int J Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 120:2, s. 447-449 Tidskriftsartikel (refereegranskat)
39.	Mattsson, Tuve, et al. (författare) The Development of a Wood-based Materials-biorefinery 2017 Ingår i: BioResources. - : North Carolina State University. - 1930-2126. ; 12:4, s. 9152-9182 Tidskriftsartikel (refereegranskat)abstract Several different methods for the extraction, separation, and purification of wood constituents were combined in this work as a unified process with the purpose of achieving a high overall efficiency of material extraction and utilization. This study aimed to present a laboratory-scale demonstrator biorefinery that illustrated how the different wood constituents could be separated from the wood matrix for later use in the production of new bio-based materials and chemicals by combining several approaches. This study builds on several publications and ongoing activities within the Wallenberg Wood Science Center (WWSC) in Sweden on the theme "From wood to material components." Combining the approaches developed in these WWSC projects - including mild steam explosion, membrane and chromatographic separation, enzymatic treatment and leaching, ionic liquid extraction, and fractionation together with Kraft pulping - formed an outline for a complete materials-biorefinery. The process steps involved were tested as integral steps in a linked process. The scale of operations ranged from the kilogram-scale to the gram-scale. The feasibility and efficiency of these process steps in a biorefinery system were assessed, based on the data, beginning with whole wood.
40.	Mattsson, Tuve, 1979, et al. (författare) The Development of a Wood-based Materials-biorefinery 2017 Ingår i: BioResources. - : BioResources. - 1930-2126 .- 1930-2126. ; 12:4, s. 9152-9182 Tidskriftsartikel (refereegranskat)abstract Several different methods for the extraction, separation, and purification of wood constituents were combined in this work as a unified process with the purpose of achieving a high overall efficiency of material extraction and utilization. This study aimed to present a laboratory-scale demonstrator biorefinery that illustrated how the different wood constituents could be separated from the wood matrix for later use in the production of new bio-based materials and chemicals by combining several approaches. This study builds on several publications and ongoing activities within the Wallenberg Wood Science Center (WWSC) in Sweden on the theme "From wood to material components." Combining the approaches developed in these WWSC projects - including mild steam explosion, membrane and chromatographic separation, enzymatic treatment and leaching, ionic liquid extraction, and fractionation together with Kraft pulping - formed an outline for a complete materials-biorefinery. The process steps involved were tested as integral steps in a linked process. The scale of operations ranged from the kilogram-scale to the gram-scale. The feasibility and efficiency of these process steps in a biorefinery system were assessed, based on the data, beginning with whole wood.
41.	Mattsson, Tuve, et al. (författare) Towards a wood based material biorefinery - A demonstrator 2015 Ingår i: 6th Nordic Wood Biorefinery Conference, NWBC 2015. - : VTT Technical Research Centre of Finland. - 9789513883539 ; , s. 92-101 Konferensbidrag (refereegranskat)abstract Wood, the most abundant ligno-cellulosic raw material available, is a key potential feedstock for production of more sustainable alternatives to fossil-based materials. However advances within the fields of extraction and treatment processes within what is often referred to as the biorefinery concept is essential to allow for such transition. In this study, several different methods for the extraction and separation of wood constituents have been combined in a single process with the purpose of achieving a high overall efficiency of material extraction and utilisation. The work builds on several activities within the Wallenberg Wood Science Center (WWSC). The aim is to present a laboratory-scale demonstrator that illustrates how the different constituents can be separated from the wood matrix for later use in the production of bio-based materials and chemicals. The process steps involved have been tested as integral steps in a linked process for a scale of operations that range from the kilogram-scale down to the gram-scale. Industrially chipped softwood, containing mainly spruce with some pine, was used as raw material.
42.	Rosdahl, Hans, et al. (författare) A microdialysis method for the in situ investigation of the action of large peptide molecules in human skeletal muscle : detection of local metabolic effects of insulin. 2000 Ingår i: International Journal of Biological Macromolecules. - : Elsevier BV. - 0141-8130 .- 1879-0003. ; 28:1, s. 69-73 Tidskriftsartikel (refereegranskat)abstract The possibility of using microdialysis catheters with a large pore size dialysis membrane (100 kDa) to investigate the action of macromolecules perfused into the interstitial space of peripheral tissues was explored. This was made possible by increasing the colloid osmotic pressure of the perfusate with 40 g/l of dextran-70 to prevent perfusate loss across the dialysis membranes. Microdialysis catheters were inserted into the quadriceps femoris muscle of 13 human subjects. With different perfusion flow rates (1. 33, 0.66, 0.33 and 0.16 microl/min) the recorded concentrations of glucose, lactate, and urea were in agreement with values previously obtained using a conventional membrane with a smaller pore size (20 kDa) [Rosdahl H, Hamrin K, Ungerstedt U, Henriksson. J Am J Physiol 1998;274:E936-45.]. When insulin was added to the perfusate, the concentration of glucose was significantly reduced, indicating that insulin diffuses across the dialysis membrane and has cellular effects that can be simultaneously recorded. The present findings are the first documentation on the use of microdialysis to study the local metabolic action of large peptide molecules in human tissues and may open new avenues for in-vivo metabolic research.
43.	Rosdahl, Hans, et al. (författare) Effect of adding a colloid to the perfusate on net fluid transport across the microdialysis membrane and on concentrations of metabolites in dialysate. Annan publikation (övrigt vetenskapligt/konstnärligt)
44.	Rosdahl, Hans, et al. (författare) Insulin perfused through a microdialysis catheter with a 100 KDa dialysis membrane induces local metabolic effects in skeletal muscle. Annan publikation (övrigt vetenskapligt/konstnärligt)
45.	Rosdahl, Hans, et al. (författare) Metabolite levels in human skeletal muscle and adipose tissue studied with microdialysis at low perfusion flow. 1998 Ingår i: The American journal of physiology. - 0002-9513. ; 274:5 Pt 1, s. E936-45 Tidskriftsartikel (refereegranskat)abstract To identify a perfusion flow at which the interstitial fluid completely equilibrates with the microdialysis perfusion fluid, a protocol with successively lower perfusion flows was used. A colloid was included in the perfusion fluid to make sampling possible at the lowest perfusion flows. At 0.16 microliter/min, the measured metabolites had reached a complete equilibration in both tissues, and the measured concentrations of glucose, glycerol, and urea were in good agreement with expected tissue-specific levels. The glucose concentration in adipose tissue (4.98 +/- 0.14 mM) was equal to that of plasma (5.07 +/- 0.07 mM), whereas the concentration in muscle (4.41 +/- 0.11 mM) was lower than in plasma and adipose tissue (P < 0.001). The concentration of lactate was higher (P < 0.001) in muscle (2.39 +/- 0.22 mM) than in adipose tissue (1.30 +/- 0.12 mM), whereas the glycerol concentration in adipose tissue (233 +/- 19.7 microM) was higher (P < 0.001) than in muscle (40.8 +/- 3.0 microM) and in plasma (68.7 +/- 3.97 microM). The concentration of urea was equal in the two tissues. Overall, the study indicates that microdialysis at a low perfusion flow may be a tool to continuously monitor tissue interstitial concentrations.
46.	Shi, Hong, et al. (författare) Prognostic impact of polymorphisms in the MYBL2 interacting genes in breast cancer 2012 Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 131:3, s. 1039-1047 Tidskriftsartikel (refereegranskat)abstract MYBL2 is a transcription factor, which regulates the expression of genes involved in cancer progression. In this study, we investigated whether putative functional variants in genes regulating MYBL2 (E2F1, E2F3 and E2F4) or in genes, which are regulated by MYBL2 (BCL2, BIRC5, COL1A1, COL1A2, COL5A2, ERBB2, CLU, LIN9 and TOP2A) affect breast cancer (BC) susceptibility and clinical outcome. Twenty-eight SNPs were genotyped in a population-based series of 782 Swedish BC cases and 1,559 matched controls. BC-specific survival analysis of BIRC5 suggested that carriers of the minor allele of rs8073069 and rs1042489 have a worse survival compared with the major homozygotes (HR 2.46, 95% CI 1.39-4.36 and HR 1.81, 95% CI 1.01-3.25, respectively). The poor survival was observed especially in women with aggressive tumours. Multivariate analysis supported the role of rs8073069 as an independent prognostic marker. For BCL2, minor allele carriers of rs1564483 were more likely to have hormone receptor-positive tumours than the major homozygotes. Another SNP in BCL2, rs4987852, was associated with tumour stages II-IV and histologic grade 3. In CLU, the minor allele carriers of rs9331888 were more likely to have tumours with regional lymph node metastasis and stages II-IV than the major homozygotes. In conclusion, our study suggests a role of genetic variation in BIRC5, BCL2 and CLU as progression and prognostic markers for BC, supporting previous studies based on the expression of the genes.
47.	Shi, Hong, et al. (författare) Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome 2011 Ingår i: Breast Cancer Research and Treatment. - New York : Springer-Verlag New York. - 0167-6806 .- 1573-7217. ; 130:3, s. 905-916 Tidskriftsartikel (refereegranskat)abstract The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and AURKA (rs2273535, rs8173) associated with steroid hormone receptor status both in a Swedish population-based cohort of 783 BC cases and in a Polish familial/early onset cohort of 506 BC cases. In the joint analysis, the minor allele carriers of rs6017452 had more often hormone receptor positive tumours (OR 0.57, 95% CI 0.40-0.81), while homozygotes for the minor allele of rs7271519, rs2273535 and rs8173 had more often hormone receptor negative tumours (2.26, 1.30-3.39; 2.39, 1.14-5.01; 2.39, 1.19-4.80, respectively) than homozygotes for the common allele. BC-specific survival analysis of AURKA suggested that the Swedish carriers of the minor allele of rs16979877, rs2273535 and rs8173 might have a worse survival compared with the major homozygotes. The survival probabilities associated with the AURKA genotypes depended on the tumour phenotype. In the Swedish case-control study, associations with BC susceptibility were observed in a dominant model for three MYBL2 promoter polymorphisms (rs619289, P = 0.02; rs826943, P = 0.03 and rs826944, P = 0.02), two AURKA promoter polymorphisms (rs6064389, P = 0.04 and rs16979877, P = 0.02) and one 3'UTR polymorphism in ZNF217 (rs1056948, P = 0.01). In conclusion, our data confirmed the impact of the previously identified susceptibility locus and provided preliminary evidence for novel susceptibility variants in BC. We provided evidence for the first time that genetic variants at 20q13 may affect hormone receptor status in breast tumours and influence tumour aggressiveness and survival of the patients. Future studies are needed to confirm the prognostic value of our findings in the clinic.
48.	Stacey, Simon N, et al. (författare) Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. 2010 Ingår i: PLoS genetics. - : Public Library of Science. - 1553-7404. ; 6:7, s. e1001029- Tidskriftsartikel (refereegranskat)abstract We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2 x 10(-3)), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9 x 10(-4)) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9 x 10(-7)), was without significant heterogeneity between ancestries (P(het) = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.
49.	Thomsen, Hauke, et al. (författare) Inbreeding and homozygosity in breast cancer survival 2015 Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5 Tidskriftsartikel (refereegranskat)abstract Genome-wide association studies (GWASs) help to understand the effects of single nucleotide polymorphisms (SNPs) on breast cancer (BC) progression and survival. We performed multiple analyses on data from a previously conducted GWAS for the influence of individual SNPs, runs of homozygosity (ROHs) and inbreeding on BC survival. (I.) The association of individual SNPs indicated no differences in the proportions of homozygous individuals among short-time survivors (STSs) and long-time survivors (LTSs). (II.) The analysis revealed differences among the populations for the number of ROHs per person and the total and average length of ROHs per person and among LTSs and STSs for the number of ROHs per person. (III.) Common ROHs at particular genomic positions were nominally more frequent among LTSs than in STSs. Common ROHs showed significant evidence for natural selection (iHS, Tajima's D, Fay-Wu's H). Most regions could be linked to genes related to BC progression or treatment. (IV.) Results were supported by a higher level of inbreeding among LTSs. Our results showed that an increased level of homozygosity may result in a preference of individuals during BC treatment. Although common ROHs were short, variants within ROHs might favor survival of BC and may function in a recessive manner.
50.	Varadi, Verena, et al. (författare) Genetic variation in ALCAM and other chromosomal instability genes in breast cancer survival 2012 Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 131:1, s. 311-319 Tidskriftsartikel (refereegranskat)abstract Chromosomal instability is a hallmark of many cancers and it has a potential to predict clinical outcome of a cancer patient. We hypothesized that genes whose expression status differs between chromosomal stable and unstable breast tumors represent target genes for the identification of genetic variants predicting breast cancer (BC) risk, disease progression, and survival. We used a published list of 38 genes associated with chromosomal instability as a basis for searching potentially functional and informative tagging single nucleotide polymorphisms (SNPs). As a result, 33 SNPs in 16 genes were genotyped in a population-based series of 783 Swedish BC cases. Two SNPs in the ALCAM gene associated with BC-specific survival. For rs1044243, the HR was 4.35 (95% CI 1.34-14.18), and for rs1157, the HR was 3.42 (95% CI 1.32-8.83) for the homozygous carriers of the minor alleles. For the minor allele carriers of CCL18 SNP rs14304, we observed a significant association with aggressive tumor characteristics: large tumor size (OR 1.53, 95% CI 1.10-2.14), positive lymph node metastasis (OR 1.75, 95% CI 1.02-3.00), and high stage (OR 1.37, 95% CI 1.02-1.85). In a Polish population consisting of 506 familial/early onset BC cases, no association with event-free survival for the ALCAM SNPs nor any association with tumor characteristics for the CCL18 SNP were observed, suggesting either a chance finding in the Swedish population or population-based or etiological differences between sporadic and familial/early onset BC.

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