| 1. |
- Mihnea, Mihaela, 1983-, et al.
(författare)
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Effect of Pre-Fermentative Strategieson the Composition of Prieto Picudo (Vitis vinífera) Red Wines
- 2016
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Ingår i: OALib Journal. - : Open Access Library (OALib). - 2333-9705 .- 2333-9721. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- The actual wine global market presents the risk of standardization of the wines and the losses of wine grape peculiarities. To combat this fact, autochthonous wine grapes are extremely interesting to use for winemaking. The use of the pre-fermentative maceration technique in autochthonous grape varieties could be an alternative of increasing their complexity. The aim of the present work was to compare the effect of five different pre-fermentative maceration treatments on the colour, phenolic and volatile composition of Prieto Picudo (PP) autochthonous red wines. The evolution during 12 months of the different wines was also studied for one vintage. Enzymatic, refrigerate and cryo-maceration treatments were applied to PP autochthonous grape varieties. The study was carried out during two consecutive vintages. Results showed that enzymatic maceration was the most effective treatment to improve levels of phenols, colour intensity and volatile compounds. Cold maceration showed also good effects. However, it was not able to improve the extractive effects of enzymatic macerations. Generally, wines obtained with pre-fermentative maceration techniques showed better colour and volatile stability than control wines.
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| 2. |
- Gatica-Ortega, María Elena, et al.
(författare)
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Nonoccupational Allergic Contact Dermatitis to 4-Acryloylmorpholine in Smartwatch Screen Protectors Glue
- 2022
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Ingår i: Dermatitis. - 1710-3568. ; 33:6, s. 429-434
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Tidskriftsartikel (refereegranskat)abstract
- Background We recently identified an outbreak of occupational allergic contact dermatitis (ACD) involving workers of a Spanish company selling smartphone protective cases from a glue product. A chemical analysis of one glue sample revealed the presence of 4-acryloylmorpholine among other allergens. The same glue is also used to attach tempered glass protective cases to Apple smartwatches. Objective Our objective was to describe a case series of nonoccupational consumer ACD from the previously mentioned Apple smartwatch protective case glue. Methods We evaluated epidemiological and clinical data, as well as patch tests results. Results Three women were diagnosed with nonoccupational ACD from the adhesive. An annular vesicular inflammatory plaque involving the dorsal aspect of the wrist was initially observed in all. Two of the 3 patients were patch tested with 4-acryloylmorpholine 0.5% with positive strong reactions. Both also strongly reacted to a sample of the glue semiopen tested in a drop of petrolatum. One of them was also positive for various acrylates. Conclusions 4-Acryloylmorpholine has been identified in an adhesive used to attach protective cases to smartwatches. Nonoccupational ACD have been described to involve consumers of smartwatches. A UV-curable adhesive used to attach protective cases to smartwatches has been considered to be the culprit.
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| 3. |
- Herreros-Montejano, Francisca, et al.
(författare)
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Outbreak of occupational allergic contact dermatitis from a smartphone screen protector glue
- 2022
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 87:1, s. 53-61
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sensitization to acrylates is a concern in the occupational/environmental dermatology field. Objective: To describe an occupational allergic contact dermatitis (ACD) outbreak from a smartphone screen protector glue. Methods: Thirteen affected workers of a chain store selling phone screen protectors were investigated in five Spanish dermatology departments. The glue datasheet and label were assessed. A chemical analysis of the glue was performed. Based on this, some patients underwent additional testing. Results: All patients (all female, mean age: 25) had severe fingertip dermatitis. The datasheet/label indicated that the glue contained isobornyl acrylate (IBOA), a “photoinitiator” and polyurethane oligomer. The company informed us that the ingredients were polyurethane acrylate, “methacrylate” (unspecified), acrylic acid, hydroxyethyl methacrylate, propylmethoxy siloxane, and photoinitiator 184. Isobornyl acrylate (or IBOA) and N,N-dimethylacrylamide (DMAA) were patch tested in eight and two cases, respectively, with negative results. A chemical analysis revealed 4-acryloylmorpholine (ACMO); isobornyl methacrylate (IBMA), and lauryl acrylate in one glue sample. Seven patients were patch tested with dilutions of the identified substances and six of seven were positive for ACMO 0.5% pet. Conclusion: An outbreak of occupational ACD, likely from ACMO in a glue is described. Further investigations are needed to corroborate the role played by each compound identified in the chemical analyses.
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| 4. |
- Krauss, Tobias, et al.
(författare)
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Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors
- 2018
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Ingår i: Endocrine-Related Cancer. - : BIOSCIENTIFICA LTD. - 1351-0088 .- 1479-6821. ; 25:9, s. 783-793
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2 cm; P < 0.001) and tumor volume doubling time (TVDT) was faster (22 vs 126 months; P = 0.001). All metastatic tumors were >= 2.8 cm. Codons 161 and 167 were hotspots for VHL germline mutations with enhanced risk for metastatic PanNETs. Multivariate prediction modeling disclosed maximum tumor diameter and TVDT as significant predictors for metastatic disease (positive and negative predictive values of 51% and 100% for diameter cut-off >= 2.8 cm, 44% and 91% for TVDT cut-off of <= 24 months). In 117 of 273 patients, PanNETs > 1.5 cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs < 2.8 cm vs >= 2.8 cm (94% vs 85% by 10 years; P = 0.020; 80% vs 50% at 10 years; P = 0.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8 cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs.
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| 5. |
- Carsin, Anne-Elie, et al.
(författare)
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Spirometric patterns in young and middle-aged adults : a 20-year European study
- 2024
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Ingår i: Thorax. - : BMJ Publishing Group Ltd. - 0040-6376 .- 1468-3296. ; 79:2, s. 153-162
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Methods We used data from the population- based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV 1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later ( ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV1/ FVC >= LLN and FVC<10th percentile, obstructive if FEV1/FVC
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| 6. |
- Dolcemascolo, Roswitha, et al.
(författare)
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Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria
- 2024
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However, RRM-containing proteins are only prevalent in eukaryotic phyla, in which they play central regulatory roles. Here, we engineered an orthogonal post-transcriptional control system of gene expression in the bacterium Escherichia coli with the mammalian RNA-binding protein Musashi-1, which is a stem cell marker with neurodevelopmental role that contains two canonical RRMs. In the circuit, Musashi-1 is regulated transcriptionally and works as an allosteric translation repressor thanks to a specific interaction with the N-terminal coding region of a messenger RNA and its structural plasticity to respond to fatty acids. We fully characterized the genetic system at the population and single-cell levels showing a significant fold change in reporter expression, and the underlying molecular mechanism by assessing the in vitro binding kinetics and in vivo functionality of a series of RNA mutants. The dynamic response of the system was well recapitulated by a bottom-up mathematical model. Moreover, we applied the post-transcriptional mechanism engineered with Musashi-1 to specifically regulate a gene within an operon, implement combinatorial regulation, and reduce protein expression noise. This work illustrates how RRM-based regulation can be adapted to simple organisms, thereby adding a new regulatory layer in prokaryotes for translation control.
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| 7. |
- Galafassi, Diego, et al.
(författare)
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‘Raising the temperature’ : the arts on a warming planet
- 2018
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Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 31, s. 71-79
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Forskningsöversikt (refereegranskat)abstract
- The search for decisive actions to remain below 1.5 °C of global temperature rise will require profound cultural transformations. Yet our knowledge of how to promote and bring about such deep transformative changes in the minds and behaviours of individuals and societies is still limited. As climate change unravels and the planet becomes increasingly connected, societies will need to articulate a shared purpose that is both engaging and respectful of cultural diversity. Thus, there is a growing need to ‘raise the temperature’ of integration between multiple ways of knowing climate change. We have reviewed a range of literatures and synthesized them in order to draw out the perceived role of the arts in fostering climate transformations. Our analysis of climate-related art projects and initiatives shows increased engagement in recent years, particularly with the narrative, visual and performing arts. The arts are moving beyond raising awareness and entering the terrain of interdisciplinarity and knowledge co-creation. We conclude that climate-arts can contribute positively in fostering the imagination and emotional predisposition for the development and implementation of the transformations necessary to address the 1.5 °C challenge.
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| 8. |
- Galafassi, Diego, et al.
(författare)
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Restoring our senses, restoring the Earth. Fostering imaginative capacities through the Arts for envisioning climate transformations
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Ingår i: Elementa. - 2325-1026.
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Tidskriftsartikel (refereegranskat)abstract
- Humanity has never lived in a world where global average temperature is above two degrees of current levels. Moving towards such High-End Climate Change (HECC) futures is likely to involve high uncertainty, non-linear dynamics in global ecologies and a fundamental challenge to current governance structures. Responding to such a world will require more than technical and conventional solutions. We depart in this paper from the notion that human imagination may be a central capacity to support multiple learning processes necessary in triggering transformative change. We developed a three-years long art-based approach to knowledge co-creation We explore the possibilities of fostering with the intention to boost imaginative capacities in support to the development of transformative societal visions. The process combines a range of performative, visual and reflexive practices with the ambition to reach out to more-than-rational but also practical elements of future visioning processes. The empirical case was realized alongside a science-led participatory knowledge co-creation process within the EU project IMPRESSIONS, in the Iberian Peninsula. Our analysis focuses on the ways in which this art-based approach brought new ways of seeing, feeling and interpreting the world given the present climate challenge. The approach supported participants in the development of a sensibility towards the future and suggested ways in which the future can be made present in order to empower and infuse action.
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| 9. |
- Galafassi, Diego, et al.
(författare)
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Restoring our senses, restoring the Earth. Fostering imaginative capacities through the arts for envisioning climate transformations
- 2018
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Ingår i: Elementa. - : University of California Press. - 2325-1026. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Humanity has never lived in a world of global average temperature above two degrees of current levels. Moving towards such High-End Climate Change (HECC) futures presents fundamental challenges to current governance structures and involves the need to confront high uncertainties, non-linear dynamics and multiple irreversibilities in global social-ecological systems. In order to face HECC, imaginative practices able to support multiple ways of learning about and experiencing the future are necessary. In this article we analysed a set of arts-based activities conducted within the five-year EU-funded project IMPRESSIONS aimed at identifying transformative strategies to high-end climate change. The exploratory artistic activities were carried out alongside a science-led participatory integrated assessment process with stakeholders from the Iberian Peninsula. Our arts-based approach combined a range of performative, visual and reflexive practices with the ambition to reach out to more-than-rational but also practical elements of HECC futures. Our study suggests that the arts-based approach helped to bring out new ways of seeing, feeling and interpreting the world which may support the development of individual and collective sensibilities needed to address HECC.
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| 10. |
- García-Martín, Noemi, et al.
(författare)
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Sugar reduction in musts with nanofiltration membranes to obtain low alcohol-content wines
- 2010
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Ingår i: Separation and Purification Technology. - : Elsevier. - 1383-5866 .- 1873-3794. ; 76:2, s. 158-170
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Tidskriftsartikel (refereegranskat)abstract
- Our aim here is to study the sugar reduction in musts to obtain wines with a slight alcohol reduction by nanofiltration. Specifically, sugar reduction is achieved by two successive nanofiltration steps. To test the method, we have worked with two types of musts: a white must from Verdejo grapes and a red one from Tinta de Toro grapes. The musts obtained from the nanofiltration treatment have been mixed with untreated must or with the retentate of the first nanofiltration stage in a proportion adequate to reduce the alcohol content of the resulting wines by 2 degrees.To verify the effectiveness of the process, each of these musts has been fermented along with an untreated control sample of the same must. The alcohol reduction in the wines has been satisfactory. However, a slight loss in the color and aroma of some compounds has been detected. (C) 2010 Elsevier B.V. All rights reserved.
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| 11. |
- Garcia-Martin, Noemi, et al.
(författare)
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Sugar reduction in white and red musts with nanofiltration membranes
- 2011
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Ingår i: Desalination and Water Treatment. - : Balaban Publishers. - 1944-3994 .- 1944-3986. ; 27:1-3, s. 167-174
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Tidskriftsartikel (refereegranskat)abstract
- In recent years the alcohol content of wine increases mainly due to climate change. Moreover, at present, consumers are increasingly demanding more aromatic and less alcoholic wines, it is due to the greater social awareness in the alcohol consumption and the regulations of the alcoholic products. The aim of this work is the reduction of sugar in the grape must to obtain wines with a slight reduction of their alcoholic degree. A reduction of sugar has been by performing two successive stages of nanofiltration. To this end, we have worked with two types of musts: one from the Verdejo variety of white grapes and the other from red grapes of the Tinta de Toro variety. Each must has been fermented both after treatment and, to be used as control, without any filtration in order to check the effectiveness of the process. Once fermentation is completed, wide-ranging analysis have been used to study all possible changes in the characteristics of the wine from a chemical point of view. The alcohol reduction reached by the wines obtained after nanofiltration and mixing of both white and red musts has been satisfactory.
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| 12. |
- Gennaro, Gisella, et al.
(författare)
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Quality Controls in Digital Mammography protocol of the EFOMP Mammo Working group
- 2018
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Ingår i: Physica Medica. - : Elsevier BV. - 1120-1797. ; 48, s. 55-64
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Tidskriftsartikel (refereegranskat)abstract
- This article aims to present the protocol on Quality Controls in Digital Mammography published online in 2015 by the European Federation of Organisations for Medical Physics (EFOMP) which was developed by a Task Force under the Mammo Working Group. The main objective of this protocol was to define a minimum set of easily implemented quality control tests on digital mammography systems that can be used to assure the performance of a system within a set and acceptable range. Detailed step-by-step instructions have been provided, limiting as much as possible any misinterpretations or variations by the person performing. It is intended that these tests be implemented as part of the daily routine of medical physicists and system users throughout Europe in a harmonised way so allowing results to be compared. In this paper the main characteristics of the protocol are illustrated, including examples, together with a brief summary of the contents of each chapter. Finally, instructions for the download of the full protocol and of the related software tools are provided.
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| 13. |
- Harmáčková, Zuzana V., et al.
(författare)
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The role of values in future scenarios : what types of values underpin (un)sustainable and (un)just futures?
- 2023
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Ingår i: Current Opinion in Environmental Sustainability. - 1877-3435 .- 1877-3443. ; 64
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Tidskriftsartikel (refereegranskat)abstract
- Values have been recognized as critical leverage points for sustainability transformations. However, there is limited evidence unpacking which types of values are associated with specific types of sustainable and unsustainable futures, as described by future scenarios and other types of futures-related works. This paper builds on a review of 460 future scenarios, visions, and other types of futures-related works in the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services Values Assessment, synthesizing evidence from academia, private sector, governmental and non-governmental strategies, science-policy reports, and arts-based evidence, to identify the types of values of nature that underlie different archetypes of the future. The results demonstrate that futures related to dystopian scenario archetypes such as Regional Competition, Inequality, and Breakdown are mostly underpinned by deeply individualistic and materialistic values. In contrast, futures with more sustainable and just outcomes, such as Global Sustainable Development and Regional Sustainability, tend to be underpinned by a more balanced combination of plural values of nature, with a dominant focus on nature’s contribution to societal (as opposed to individual) aspects of well-being. Furthermore, the paper identifies research gaps and illustrates the key importance of acknowledging not only people’s specific values directly related to nature, such as instrumental, intrinsic, and relational human-nature values and relationships, but also broad values and worldviews that affect the interactions between nature and society, with resulting impacts on Nature's Contributions to People and opportunities for a good quality of life.
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| 14. |
- Heras, María, et al.
(författare)
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Realising potentials for arts-based sustainability science
- 2021
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Ingår i: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4065 .- 1862-4057. ; 16:6, s. 1875-1889
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Tidskriftsartikel (refereegranskat)abstract
- In recent years, a profusion of methods, practices, and experiences has emerged in the interface between arts and sustainability science. Drawing from two strong currents within sustainability science, namely, the emphasis on transdisciplinary approaches and the need to move towards societal transformations, such hybrid approaches seemingly contribute with unique methods to sustainability research. Despite repeated claims from sustainability scientists about art’s role in sustainability transformations, joint analyses with artists and practitioners are still rare. We conveyed a collaborative and exploratory workshop with scientists, artists, and practitioners from the fields of education, public engagement, and activism to identify the potentials for arts-based sustainability research. Participants were invited to facilitate and trial various artistic practices from disciplines of performative, literary, narrative, audio-visual and plastic arts. In this paper, we present five key areas identified in the workshop, where arts-based methods can significantly contribute to sustainability research: embracing more-than-cognitive aspects of knowledge, improving communication, grappling with power dynamics, shifting relationships to nature, and facilitating futures visioning. Workshop participants also identified challenges related to power dynamics, tensions across paradigms, and implementation conditions, providing insights into how to leverage arts’ potential to respond to global environmental challenges while boosting societal transformations. We then discuss research questions identified that address challenges and limitations for arts-based research in sustainability. Overall, these results suggest there are yet untapped resources and experiences within the field of arts-based sustainability science. (Audio-visual abstract available on S1).
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| 15. |
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| 16. |
- Mörtberg, Anders, 1986, et al.
(författare)
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Towards a Certified Computation of Homology Groups for Digital Images
- 2012
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Ingår i: Massimo Ferri, Patrizio Frosini, Claudia Landi, Andrea Cerri, Barbara Di Fabio (Eds.): Computational Topology in Image Context - 4th International Workshop, CTIC 2012, Bertinoro, Italy, May 28-30, 2012. Proceedings. Lecture Notes in Computer Science. - 9783642302374 ; 2012:7309, s. 49-57
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Konferensbidrag (refereegranskat)abstract
- In this paper we report on a project to obtain a verified computation of homology groups of digital images. The methodology is based on programming and executing inside the Coq proof assistant. Though more research is needed to integrate and make efficient more processing tools, we present some examples partially computed in Coq from real biomedical images.
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| 17. |
- Perez-Segura, Pedro, et al.
(författare)
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BRCA2 gene mutations and coagulation-associated biomarkers
- 2016
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 115:2, s. 415-423
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Tidskriftsartikel (refereegranskat)abstract
- Thromboembolic events are the second cause of death in cancer patients, although the mechanisms underlying this increased thromboembolic risk remain unclear. The aims of this study were to examine whether BRCA2 gene mutations may modify the circulating levels of thrombocoagulation biomarkers and whether breast cancer development may influence changes in such circulating biomarkers. The study was performed in 25 women with mutations in the BRCA2 gene (n=12 breast cancer, n=13 breast cancer-free) and in 13 BRCA2 nonmutant controls. Results revealed that plasma levels of fibrinogen gamma chain isotypes 2 and 3, haptoglobin isotypes 4 and 5, serotransferrin isotypes 3 and 4 and convertase C3/C5 isotypes 4 and 5 were significantly higher in BRCA2 mutation carriers compared to controls. However, plasma levels of vitamin D binding protein isotype 1 and alpha1-antitrypsin isotypes 2, 3 and 4 were significantly decreased in BRCA2 mutation carriers compared to controls. Plasma expression of PF4 and P-selectin was significantly higher in BRCA2 mutations carriers than in controls. BRCA2 truncated mutations conserving a binding region for RAD51 were associated with increased plasma levels of alpha1-antitrypsin isotypes 3 and 4 with respect to women showing BRCA2 mutations that loss the binding RD51 region to BRCA2. Only plasma levels of vitamin D binding protein isotypes 1 and 3 were significantly reduced and alpha 1-antitrypsin isotype 1 was increased in cancer-free BRCA2 mutation carriers compared to BRCA2 mutation carriers with breast cancer. The presence of BRCA2 mutations is associated with increased plasma levels of thrombo-coagulating- related proteins, which are independent to breast cancer development.
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| 18. |
- Rivas, Ana, et al.
(författare)
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Association of bisphenol A exposure with dietary quality indices in Spanish schoolchildren
- 2016
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Ingår i: Food and Chemical Toxicology. - Oxford, United, Kingdom : Elsevier. - 0278-6915 .- 1873-6351. ; 94, s. 25-30
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Tidskriftsartikel (refereegranskat)abstract
- Young children, whose growth and development are highly dependent on the endocrine system, are particularly vulnerable to endocrine disruptor exposure. The main objectives of this study were to measure BPA migration levels from cans, fruit juice bottles/packs, and microwave containers used for food/drinks consumed by a sample of 6- to 8-year old schoolchildren in Spain and to estimate the relationship between their resulting BPA exposure and diet quality index scores (Mediterranean Diet Score and Breakfast Quality Index). The mean BPA concentration was 11.8 ng/mL for vegetable cans, 22.1 ng/mL for pulse cans, 3.6 ng/mL for juice bottles/packs, and 1.2 ng/mL for microwave containers. Results revealed a significant association between the Mediterranean Diet Score and low BPA exposure of the children. BPA exposure below the median level was significantly associated with a higher score in both the first-grade (P = 0.030) and second-grade (p = 0.0001) groups. However, no association was found between BPA exposure and the Breakfast Quality Index. In conclusion, children with a stronger adherence to a Mediterranean-like diet appear to be less exposed to BPA migrating from food packaging and microwave containers. Further research is warranted on the inadvertent exposure of children to endocrinedisrupting chemicals from these sources.
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| 19. |
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| 20. |
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