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- Larsson, Matilda, et al.
(författare)
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Assessment of longitudinal strain in the Carotid artery wall using ultrasound-based Speckle tracking - validation in a sheep model
- 2013
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Ingår i: Proceedings of the IEEE International Ultrasonics symposium, 2013.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Assessment of strain in the longitudinal direction of the arterial wall has been suggested to improve the evaluation of arterial stiffness and atherosclerosis. Recently, we showed the feasibility of ultrasound speckle tracking to assess carotid longitudinal strain in-silico and in-vitro. However, validation in the more challenging in-vivo setting is still lacking. The aim of this study was to validate longitudinal strain assessment in the common carotid artery (CCA) in an animal setup. The left CCAs of five sheep were exposed during Isoflurane anesthesia and sonomicrometry crystals were sutured onto the artery wall to obtain reference longitudinal strain. Ultrasound long-axis images were recorded at baseline and hypertension (Phenylephrine) and an in-house speckle tracking algorithm was applied to estimate longitudinal strain. The estimated strain curves varied cyclically throughout the cardiac cycles, showing a lengthening of the arterial segment in systole. A significant correlation between peak systolic estimated and reference strain was found (r=0.95, p < 0.001). The results indicate the feasibility of arterial longitudinal strain assessment in-vivo using ultrasound speckle tracking.
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| 2. |
- Larsson, Matilda, et al.
(författare)
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Strain assessment in the carotid artery wall using ultrasound speckle tracking : validation in a sheep model.
- 2015
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 60:3, s. 1107-
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to validate carotid artery strain assessment in-vivo using ultrasound speckle tracking. The left carotid artery of five sheep was exposed and sonomicrometry crystals were sutured onto the artery wall to obtain reference strain. Ultrasound imaging was performed at baseline and stress, followed by strain estimation using an in-house speckle tracking algorithm tuned for vascular applications. The correlation between estimated and reference strain was r = 0.95 (p < 0.001) and r = 0.87 (p < 0.01) for longitudinal and circumferential strain, respectively. Moreover, acceptable limits of agreement were found in Bland-Altman analysis (longitudinally: -0.15 to 0.42%, circumferentially: -0.54 to 0.50%), which demonstrates the feasibility of estimating carotid artery strain using ultrasound speckle tracking. However, further studies are needed to test the algorithm on human in-vivo data and to investigate its potential to detect subclinical cardiovascular disease and characterize atherosclerotic plaques.
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