| 1. |
- Bertilsson, Carolina, 1990, et al.
(författare)
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Prevalence of Dental Caries in Past European Populations: A Systematic Review
- 2022
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Ingår i: Caries Research. - : S. Karger AG. - 0008-6568 .- 1421-976X. ; 56:1, s. 15-28
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Within the fields of anthropology and osteoarcheology, human teeth have long been studied to understand the diet, habits, and diseases of past civilizations. However, no complete review has been published to collect and analyze the extensive available data on caries prevalence in European man (Homo sapiens) over time. Method: In this current study, the two databases, Scopus and Art, Design, and Architecture Collection, were searched using predefined search terms. The literature was systematically reviewed and assessed by two of the authors. Results: The findings include a significant nonlinear correlation with increasing caries prevalence in European populations from 9000 BC to 1850 AD, for both the number of carious teeth and the number of affected individuals. Conclusion: Despite the well-established collective belief that caries rates fluctuate between different locations and time and the general view that caries rates have increased from prehistoric times and onwards, this is to our knowledge the first time this relationship has been proven based on published data.
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| 2. |
- Allosso, Francesca, et al.
(författare)
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Mortality in patients with adrenal insufficiency: a protocol for a systematic review and meta-analysis.
- 2024
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Ingår i: BMJ open. - 2044-6055. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Adrenal insufficiency (AI) is a rare disorder characterised by an impaired secretion of glucocorticoids from the adrenal glands. Treatment strategies for AI have developed over time with reduced glucocorticoid replacement doses and improved circadian exposure regimens, but whether this has resulted in better survival is unknown. The main purpose of this systematic review is to gather and synthesise available evidence on long-term mortality in patients with AI. The secondary aim is to study causes of death, with focus on cardiovascular and infectious diseases, in AI patients.Studies published from the inception of respective databases (Medline, Embase, Cochrane and Web of Science) until the end of May 2023 will be systematically synthetised. Observational studies with a reference population will be included, and their quality will be assessed using the Newcastle-Ottawa scale. Data collected will be narratively integrated and a meta-analysis will be performed to pool data from studies considered homogeneous. The systematic review will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This will be the first systematic review assessing mortality and causes of death in AI patients. The findings of this systematic review will be of value for both patients and healthcare providers.This systematic review does not require ethical approval or informed consent because it will be based on previously published data only and does not implicate any direct contact with individual patients. The research results will be presented at scientific conferences and submitted for publication in an internationally recognised peer-reviewed scientific journal.CRD42023416253.
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| 3. |
- Bjarsch, Carin, 1973, et al.
(författare)
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Söka & värdera. Nätbaserad introduktion till informationssökning och informationshantering
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med rapporten är att berätta om projektgruppens arbete med att utveckla webbkursen Söka & värdera: Grundkurs i informationssökning och informationshantering. Målgrupp för webbkursen är alla nyantagna studenter vid Göteborgs universitet. Nya studenter kommer till GU med varierande kunskaper i informationssökning och informationshantering. Idag når bibliotekets undervisning långt ifrån alla studenter. En kurs på webben ger ökad flexibilitet och tillgänglighet och därmed möjlighet att nå fler studenter. Söka & värdera syftar till att lägga en gemensam kunskapsgrund för nyantagna studenter vad gäller informationssökning och informationshantering. Kursen fungerar också som utgångspunkt för universitetsbibliotekets fortsatta, ämnesanpassade fördjupningskurser. Därmed får studenterna möjlighet att rusta sig bättre för sina högskolestudier. Ett effektmål blir alltså att kursen bidrar till att höja kvaliteten i grundutbildningen och underlättar genomströmningen. Kursinnehållet täcker de generiska kompetenser som omfattas av Högskolelagen och som brukar sammanfattas som informationskompetens: förmågan att söka, kritiskt värdera och (etiskt) hantera information. Webbkursen är också en del av universitetsbibliotekets arbete med GU:s handlingsplan mot fusk/plagiering. Webbkursen lanserades i september 2011 och har sedan dess presenterats i flera sammanhang och fått ett positivt mottagande. Dessutom har fyra studentgrupper fått testa och utvärdera kursen. Kursen Söka & värdera gör det möjligt för institutioner/fakulteter att försäkra sig om att alla studenter erbjuds möjlighet att tillägna sig grundläggande kunskaper om informationssökning, informationshantering och akademisk hederlighet. För att nå alla nya studenter vid Göteborgs universitet behövs ett GU-gemensamt beslut att göra kursen obligatorisk.
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| 4. |
- Bobbio, Emanuele, et al.
(författare)
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Inflammatory cardiomyopathies: short- and long-term outcomes after heart transplantation-a protocol for a systematic review and meta-analysis.
- 2020
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Ingår i: Heart failure reviews. - : Springer Science and Business Media LLC. - 1573-7322 .- 1382-4147. ; 25:3, s. 481-485
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Tidskriftsartikel (refereegranskat)abstract
- Heart transplantation (HTx) for patients with "giant cell myocarditis" (GCM) or "cardiac sarcoidosis" (CS) is still controversial. However, no single center has accumulated enough experience to investigate post-HTx outcome. The primary aim of this systematic review is to identify, appraise, and synthesize existing literature investigating whether patients who have undergone HTx because of GCM or CS have worse outcomes as compared with patients transplanted because of other etiologies. A systematic and comprehensive search will be performed using PubMed, Scopus, Web of Science, EMBASE, and Google Scholar, for studies published up to December 2019. Observational and interventional population-based studies will be eligible for inclusion. The quality of observational studies will be assessed using the Newcastle-Ottawa scale, while the interventional studies will be assessed using the Cochrane Effective Practice Organization of Care tool. The collected evidence will be narratively synthesized; in addition, we will perform a meta-analysis to pool estimates from studies considered to be homogenous. Reporting of the systematic review and meta-analysis will be in accordance with the Meta-analysis of Observational Studies in Epidemiology Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines. To our knowledge, this will be the first synthesis of outcomes, including survival, acute cellular rejection, and disease recurrence, in patients with either GCM or CS treated with HTx. Reviewing the suitability of HTx in this population and highlighting areas for further research will benefit both patients and healthcare providers. Trial registration: CRD42019140574.
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| 5. |
- Bobbio, Emanuele, et al.
(författare)
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Short- and long-term outcomes after heart transplantation in cardiac sarcoidosis and giant-cell myocarditis: a systematic review and meta-analysis.
- 2022
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Ingår i: Clinical research in cardiology : official journal of the German Cardiac Society. - : Springer Science and Business Media LLC. - 1861-0692. ; 111:2, s. 125-140
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Tidskriftsartikel (refereegranskat)abstract
- Heart transplantation (HTx) is a valid therapeutic option for end-stage heart failure secondary to cardiac sarcoidosis (CS) or giant-cell myocarditis (GCM). However, post-HTx outcomes in patients with inflammatory cardiomyopathy (ICM) have been poorly investigated. We searched PubMed, Scopus, Science Citation Index, EMBASE, and Google Scholar, screened the gray literature, and contacted experts in the field. We included studies comparing post-HTx survival, acute cellular rejection, and disease recurrence in patients with and without ICM. Data were synthesized by a random-effects meta-analysis. We screened 11,933 articles, of which 14 were considered eligible. In a pooled analysis, post-HTx survival was higher in CS than non-CS patients after 1year (risk ratio [RR] 0.88, 95% confidence interval [CI] 0.60-1.17; I2=0%) and 5years (RR 0.72, 95% CI 0.52-0.91; I2=0%), but statistically significant only after 5years. During the first-year post-HTx, the risk of acute cellular rejection was similar for patients with and without CS, but after 5years, it was lower in those with CS (RR 0.38, 95% CI 0.03-0.72; I2=0%). No difference in post-HTx survival was observed between patients with and without GCM after 1year (RR 1.16, 95% CI 0.05-2.28; I2=0%) or 5years (RR 0.98, 95% CI 0.42-1.54; I2=0%). During post-HTx follow-up, recurrence of CS and GCM occurred in 5% and 8% of patients, respectively. Post-HTx outcomes in patients with CS and GCM are comparable with cardiac recipients with other heart failure etiologies. Patients with ICM should not be disqualified from HTx.
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| 6. |
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| 7. |
- Hessman, Eva, 1961, et al.
(författare)
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Stöd och samarbete för studenters lärande: UB som pedagogisk partner
- 2013
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Ingår i: ABSTRACTS HKG 2013 : Högskolepedagogisk konferens i Göteborg, 17 oktober 2013. ; , s. 26-27
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Vi bjuder in till en diskussion om UB:s roll som pedagogiskt stöd för studenterna på GU, både i form av klassrumsundervisning men även i form av olika webbstöd.
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| 8. |
- Nilsson, Christina, et al.
(författare)
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Causes and outcomes in studies of fear of childbirth: A systematic review
- 2018
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Ingår i: Women and Birth. - 1871-5192 .- 1878-1799.
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Forskningsöversikt (refereegranskat)abstract
- PROBLEM:Fear of childbirth negatively affects women during pregnancy and after birth.AIM:To summarise the findings of published studies regarding possible causes/predisposing factors and outcomes of fear of childbirth for childbearing women.DESIGN:A systematic review, searching five databases in March 2015 for studies on causes/predisposing factors and outcomes of fear of childbirth, as measured during pregnancy and postpartum. Quality of included studies was assessed independently by pairs of authors. Data were extracted independently by reviewer pairs and described in a narrative analysis.FINDINGS:Cross-sectional, register-based and case-control studies were included (n=21). Causes were grouped into population characteristics, mood-related aspects, and pregnancy and birth-related aspects. Outcomes were defined as mood-related or pregnancy and birth-related aspects. Differing definitions of fear of childbirth were found and meta-analysis could only be performed on parity, in a few studies.CONCLUSIONS:Stress, anxiety, depression and lack of social support are associated with fear during pregnancy. Need for psychiatric care and presence of traumatic stress symptoms are reported outcomes together with prolonged labour, longer labours, use of epidural and obstetric complications. Nulliparous and parous women have similar levels of fear but for different reasons. Since the strongest predictor for fear in parous women is a previous negative birth experience or operative birth, we suggest it is important to distinguish between fear of childbirth and fear after birth. Findings demonstrate the need for creating woman-centred birthing environments where women can feel free and secure with low risk of negative or traumatic birth experiences and consequent fear.
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| 9. |
- Nilsson, Christina, 1959, et al.
(författare)
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Definitions, measurements and prevalence of fear of childbirth: a systematic review
- 2018
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Ingår i: Bmc Pregnancy and Childbirth. - : Springer Science and Business Media LLC. - 1471-2393. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Fear of Childbirth (FOC) is a common problem affecting women's health and wellbeing, and a common reason for requesting caesarean section. The aims of this review were to summarise published research on prevalence of FOC in childbearing women and how it is defined and measured during pregnancy and postpartum, and to search for useful measures of FOC, for research as well as for clinical settings. Methods: Five bibliographic databases in March 2015 were searched for published research on FOC, using a protocol agreed a priori. The quality of selected studies was assessed independently by pairs of authors. Prevalence data, definitions and methods of measurement were extracted independently from each included study by pairs of authors. Finally, some of the country rates were combined and compared. Results: In total, 12,188 citations were identified and screened by title and abstract; 11,698 were excluded and full-text of 490 assessed for analysis. Of these, 466 were excluded leaving 24 papers included in the review, presenting prevalence of FOC from nine countries in Europe, Australia, Canada and the United States. Various definitions and measurements of FOC were used. The most frequently-used scale was the W-DEQ with various cut-off points describing moderate, severe/intense and extreme/phobic fear. Different 3-, 4-, and 5/6 point scales and visual analogue scales were also used. Country rates (as measured by seven studies using W-DEQ with >= 85 cut-off point) varied from 6.3 to 14.8%, a significant difference (chi-square = 104.44, d.f. = 6, rho < 0.0001). Conclusions: Rates of severe FOC, measured in the same way, varied in different countries. Reasons why FOC might differ are unknown, and further research is necessary. Future studies on FOC should use the W-DEQ tool with a cut-off point of >= 85, or a more thoroughly tested version of the FOBS scale, or a three-point scale measurement of FOC using a single question as 'Are you afraid about the birth?' In this way, valid comparisons in research can be made. Moreover, validation of a clinical tool that is more focussed on FOC alone, and easier than the longer W-DEQ, for women to fill in and clinicians to administer, is required.
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| 10. |
- Nilsson, Christina, et al.
(författare)
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Effects of Birthing Room Design on Maternal and Neonate Outcomes: A Systematic Review
- 2020
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Ingår i: Herd-Health Environments Research & Design Journal. - : SAGE Publications. - 1937-5867 .- 2167-5112. ; 13:3, s. 198-214
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To summarize, categorize, and describe published research on how birthing room design influences maternal and neonate physical and emotional outcomes. Background: The physical healthcare environment has significant effects on health and well-being. Research indicates that birthing environments can impact women during labor and birth. However, summaries of the effects of different environments around birth are scarce. Methods: We conducted a systematic review, searching 10 databases in 2016 and 2017 for published research from their inception dates, on how birthing room design influences maternal and neonate physical and emotional outcomes, using a protocol agreed a priori. The quality of selected studies was assessed, and data were extracted independently by pairs of authors and described in a narrative analysis. Results: In total, 3,373 records were identified and screened by title and abstract; 2,063 were excluded and the full text of 278 assessed for analysis. Another 241 were excluded, leaving 15 articles presenting qualitative and quantitative data from six different countries on four continents. The results of the analysis reveal four prominent physical themes in birthing rooms that positively influence on maternal and neonate physical and emotional outcomes: (1) means of distraction, comfort, and relaxation; (2) raising the birthing room temperature; (3) features of familiarity; and (4) diminishing a technocratic environment. Conclusions: The evidence on how birthing environments affect outcomes of labor and birth is incomplete. There is a crucial need for more research in this field.
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| 11. |
- Nilsson, Stefan, 1972, et al.
(författare)
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Paediatric palliative care: a systematic review.
- 2020
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Ingår i: BMJ Supportive & Palliative Care. - : BMJ. - 2045-4368 .- 2045-435X. ; 10:2
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Forskningsöversikt (refereegranskat)abstract
- To review literature relating to evidence, context and facilitation to describe knowledge translation in paediatric palliative care. Paediatric palliative care requires competences including both paediatric specialists as well as services that are developed for this purpose, and there is a need to facilitate paediatric palliative care knowledge translation. Promoting Action on Research Implementation in the Health Services (PARiHS) is a framework for knowledge translation, which highlights the relationships between evidence, context and facilitation. PARiHS framework has been revised and updated in a new version called i-PARiHS.The electronic databases AgeLine, CINAHL, The Cochrane Library, PsycINFO, PubMed and Scopus were searched. Papers included were limited to English and Swedish publications and restricted to publications dated between 1993 and August 2019. All types of observational and experimental studies using any research design were included.Thirty-eight articles were included and there was a common vision about how and when palliative care should be offered to children. The i-PARiHS was used as a lens to describe the knowledge translation in paediatric palliative care. Symptom relief was the most commonly described evidence-based strategy, and the hospital environment was the most commonly described context. Different types of education were the most commonly used strategies to facilitate knowledge translation. The results mainly focused on increasing knowledge of palliative care in paediatric care. To sum up, the results report strategies to achieve knowledge translation of paediatric palliative care, and these can be interpreted as a guideline for how this process can be facilitated.CRD42018100663.
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| 12. |
- Rocca, Aldo, et al.
(författare)
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Therapeutic outcomes with surgical and medical management for primary aldosteronism: protocol for a systematic review and meta-analysis.
- 2023
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Ingår i: BMJ open. - 2044-6055. ; 13:7
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Tidskriftsartikel (refereegranskat)abstract
- Treatment strategies for primary aldosteronism (PA) include unilateral adrenalectomy and medical treatment with mineralocorticoid receptor (MR) antagonists. Whether these two different treatment strategies are comparable in mitigating the detrimental effect of PA on outcomes is still debated.The primary aim of this systematic review is to identify, appraise and synthesise existing literature comparing clinical outcomes after treatment in patients with PA.A systematic and comprehensive search will be performed using PubMed, Web of Science and EMBASE, for studies published until December 2022. Observational and interventional studies will be eligible for inclusion. The quality of observational studies will be assessed using the Newcastle-Ottawa Scale, while interventional studies will be assessed using the Cochrane Effective Practice Organization of Care tool. The collected evidence will be narratively synthesised. We will perform meta-analysis to pool estimates from studies considered to be homogeneous. Reporting of the systematic review and meta-analysis will be in accordance with the Meta-analysis of Observational Studies in Epidemiology Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines.As this study is based solely on the published literature, no ethics approval is required. This review will aim to provide some estimates on outcomes, including survival, rates of clinical and biochemical control, cardiovascular and cerebrovascular events, as well as data on quality of life and renal function, in patients with PA treated surgically or with MR antagonists. The study findings will be presented at scientific meetings and will be published in an international peer-reviewed scientific journal.CRD42022362506.
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| 13. |
- Schüttengruber, Gerhilde, et al.
(författare)
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Understanding ageism towards older nursing staff and service users: A systematic mapping review from the perspective of clinical leaders and healthcare managers
- 2024
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Ingår i: Geriatric Nursing. - 0197-4572 .- 1528-3984.
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Forskningsöversikt (refereegranskat)abstract
- Introduction: Ageist attitudes negatively affect the quality of care for service users and the working conditions of older nursing staff. Clinical leaders’ perceptions of older service users and nursing staff are unknown. Aim: To mapresearch evidence onageist attitudes in healthcare towards service users and older nursing staff, from the leadership perspective. Material and Methods: A systematic mapping review with database searches in March 2021 and May 2023). Nineteen articles (qualitative n = 13, quantitative n = 3, mixed methods n = 3) were analysed and mapped to the Nurse Executive Capability Framework. Results: Future planning, team building, and self-awareness are leadership categories requiring consideration. Guidelines and policies addressing the holistic needs of older service users and older nursing staff are lacking. Conclusions: Organizational planning, team building, and self-awareness are crucial for the holistic care of older service users and for creating attractive workplaces for older nursing staff.
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| 14. |
- Sjöblom, Helen, 1976, et al.
(författare)
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Student-activating methods in information literacy
- 2018
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Ingår i: European Association for Health Information and Libraries Conference, Cardiff UK, 9-13 July, 2018.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Student-activating methods in information literacy Student-active learning is a buzzword in pedagogical discussions at many universities. One way to facilitate the use of student-activating methods is through the establishing of Active Learning Classrooms (ALC). ALCs are, as the name suggests, spaces designed for active learning, furnished with round tables where students are seated in groups. Each table is equipped with their own wall-mounted LCD and whiteboard, see https://cei.umn.edu/support-services/tutorials/active-learning-classrooms The teaching in ALCs requires a shift from the traditional pedagogical ideas of knowledge transmission through teachers giving lectures. Learning in the ALC, in contrast, is thought to be achieved through collaboration between peers, problem solving and designated student activities. The teacher consequently becomes more like a tutor or facilitator. (Brooks, 2014) In 2013 the Education team at the Biomedical Library, Gothenburg University, started the transition towards a more student-centered approach in our information literacy courses. We gradually introduced more and more exercises in class where students were encouraged to work together in small groups. In 2015 we realized that our current classrooms (i.e. computer rooms) were too much of an obstacle for us to be able to continue developing our teaching in the direction that we wanted. Thus, the process of reconstructing the rooms to ALCs began. In August 2016 our two ALCs were ready for use and since then we have taught more than 5000 students for a total of 970 class hours. The new classrooms and pedagogical approach has over all been well received by students, as shown by course evaluations. We experience a continuously growing interest in our pedagogy and the ALCs from faculty. It has opened up opportunities for new exciting collaborations both within the university and with librarians from a diversity of organizational backgrounds. The image of librarians as pedagogues and our competences regarding development and innovation are also strengthened. This CEC will outline the work that was undertaken to transform the predominantly lecture-based information literacy instructional activities into more student-centered sessions better suited for Active Learning Classrooms. Questions that will be covered: How does one go about devising active learning activities for the fostering of information literacy in students? How does one alleviate fears about the teacher’s diminished control over the course of events in the classroom, which might accompany the redirected focus from teacher performance to student engagement? How does one handle the fact that active learning activities usually mean that less content will be covered in-class as compared to traditional lecturing? We will give hands-on examples with exercises and activities tailored to enhance student information literacy skills, for example choosing search terms, the critical reviewing and evaluating of sources, developing search strategies, and reference writing. This CEC will serve as an inspiration for teaching librarians who are in the process of developing their pedagogy using student-activating methods, whether in an Active Learning Classroom or in a more traditional classroom setting. Brooks et al. (2014). Pedagogy matters, too: The impact of adapting teaching approaches to formal learning environments on student learning. New Directions for Teaching and Learning, 2014(137), 53-61.
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| 15. |
- Sjöblom, Helen, 1976, et al.
(författare)
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Transforming the image of the library: from economic burden to a valued expert contributor
- 2023
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Ingår i: EAHIL workshop, 12–16 June 2023, Trondheim.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Purpose: October 2022 our library established a dedicated team for researcher support. It has been a long journey to reach this re-organization. During the session we will walk you through the process, discuss the implications of being a team, and try to envision what lays ahead. Background: In the last decade, we have seen a change of focus, from mainly providing services for our inhouse users, the undergraduate students, to broaden the scope and reach out to researchers and doctoral students as well. In 2013 a project was initiated with the purpose to explore how to better meet the needs of researchers and doctoral students. The project resulted in the formation of designated work groups for researcher services at each of the three disciplinary library branches. These groups were expected to develop a local service while still maintaining their regular work tasks. A variety of initiatives was taken by these groups to increase awareness of the extended services targeted at researchers. At the Biomedical library, the working group activities were really successful. As a result of our outreach activities, we soon saw an increased demand for counselling regarding information retrieval, research impact, publication strategies, reference management software and last but not least methodological support for systematic reviews. Gradually, responding to all incoming matters and working in multiple systematic review projects got hard to fit within the regular professional frames, an experience we share with other librarians developing services for researchers (Campbell 2015, Roth. 2018). By stressing the unmanageable work load, and at the same time showing evidence of a highly appreciated service, we were able to convince the local library management to give us the opportunity; In October 2022 the decision finally came, and an independent team was established – Team Researcher Support. Increased demand was however not equally distributed in all disciplines and all library branches. The Faculty of Medicine stood out in their readiness to accept, appreciate and make use of the services offered, and to value and validate the expertise added by librarian participation in a diversity of contexts. A recent dissertation investigating the implementation of library services for researchers shows the same pattern (Eklund 2022). Today our service mainly consists of systematic review support, teaching doctoral courses and invitations to do talks or to write about publication ethics and predatory journals. The opportunity to focus on a single, if yet broad, task gives us the time to work more proactive. We will be able to broaden our scope, learn more about emerging topics and evaluate different aspects of library related areas, such as subject specific publishing patterns and open science. Summary By changing our professional role, from generalist to specialist, we are able to offer a tailored service and respond to new and emerging topics in academia. The organizational image of the library is hence transformed, from being perceived as an economic burden only. We are now in a position where researchers and faculty turn to us for advice (Eklund 2022). Campbell et al. 2015. What to do when everyone wants you to collaborate: managing the demand for library support in systematic review searching. Journal of the Canadian Health Libraries Association. 36(1): 11-19. https://doi.org/10.29173/jchla/jabsc.v36i1.24353 Eklund. 2022. Academic librarianship in flux: The dynamics of negotiating professional jurisdiction. Dissertation, University of Borås. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-26641 Roth. 2018. Transforming the systematic review service: a team-based model to support the educational needs of researchers. Journal of the Medical Library Association: JMLA 106(4): 514-520. https://doi.org/10.5195/jmla.2018.430
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| 16. |
- Varkey, Jonas, 1980, et al.
(författare)
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Diagnostic yield for video capsule endoscopy in gastrointestinal graft- versus -host disease: a systematic review and metaanalysis.
- 2023
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Ingår i: Scandinavian journal of gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 58:8, s. 945-952
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Tidskriftsartikel (refereegranskat)abstract
- The gastrointestinal tract is the second most involved organ for graft-versus-host disease where involvement of the small intestine is present in 50% of the cases. Therefore, the use of a non-invasive investigation i.e., video capsule endoscopy (VCE) seems ideal in the diagnostic work-up, but this has never been systematically evaluated before.The aim of this systematic review was to determine the efficacy and safety of VCE, in comparison with conventional endoscopy in patients who received hematopoietic stem cell transplantation.Databases searched were PubMed, Scopus, EMBASE, and Cochrane CENTRAL. All databases were searched from their inception date until June 17, 2022. The search identified 792 publications, of which 8 studies were included in our analysis comprising of 232 unique patients. Efficacy was calculated in comparison with the golden standard i.e., histology. Risk of bias assessment was performed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.The pooled sensitivity was higher for VCE at 0.77 (95% CI: 0.60-0.89) compared to conventional endoscopy 0.62 (95% CI: 0.47-0.75) but the difference was not statistically significant (p=0.155, Q=2.02). Similarly, the pooled specificity was higher for VCE at 0.68 (95% CI: 0.46-0.84) than for conventional endoscopy at 0.58 (95% CI: 0.40-0.74) but not statistically significant (p=0.457, Q=0.55). Moreover, concern for adverse events such as intestinal obstruction or perforation was not justified since none of the capsules were retained in the small bowel and no perforations occurred in relation to VCE. A limitation to the study is the retrospective approach seen in 50% of the studies.The role of video capsule endoscopy in diagnosing or dismissing graft-versus-host disease is not yet established and requires further studies. However, the modality appears safe in this cohort.
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| 17. |
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| 18. |
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| 19. |
- Öhlén, Joakim, 1958, et al.
(författare)
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Strategies for knowledge translation of a palliative approach outside specialized palliative care services: a scoping review.
- 2022
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Ingår i: BMC Palliative Care. - : Springer Science and Business Media LLC. - 1472-684X. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Research suggests palliative care to be translated and integrated in non-specialized palliative care services throughout the palliative care continuum across populations and settings. A need has been identified to build on the existing research literature in order to design strong knowledge translation strategies that can be evaluated in future research. The aim was to map strategies for knowledge translation of a palliative approach to care into non-specialized palliative care services for adult patients. The objectives were to explore the primary research activities, the specific type of knowledge translation strategies used, the research designs and study settings for such evaluations along with the major results thereof, and to identify major research gaps in this area.A scoping review was performed to map the volume and characteristics of research literature (project registered in PROSPERO #2018 CRD42018100663). The ten-year period 2010 to 2019 was searched in six major databases for original articles published in English in which the knowledge translation of a palliative approach for adult patients was evaluated in non-specialized palliative healthcare settings, and all type of empirical data-based research designs. We excluded non-English, non-empirical articles, non-evaluation of knowledge translations, specialized palliative care settings, and other types of publications (i.e. non-original articles).Most of the 183 included articles focused on patients with cancer who were dying in hospitals and in high income countries. Only 13 articles focused on early palliative care. A palette of different strategies was used to implement palliative care in non-specialist palliative settings; no strategy was identified as outstanding. The majority of the articles had unspecified essential components of the research designs.Previous suggestions for utilization of implementation science for knowledge translation of a palliative approach to care into non-specialized palliative care services are confirmed, and established knowledge translation theories can strengthen the field. To advance this specific field of knowledge, meticulously detailed reporting of studies is required as related to research designs, clarifications of contextual influences and mechanisms at work. Specific systematic reviews and meta-syntheses in the field are merited.
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