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- Voss, Erica A, et al.
(författare)
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Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.
- 2023
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Ingår i: EClinicalMedicine. - 2589-5370. ; 58
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Tidskriftsartikel (refereegranskat)abstract
- Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of AESIs following SARS-CoV-2 infection in patients and compare these to historical rates in the general population.A multi-national cohort study with data from primary care, electronic health records, and insurance claims mapped to a common data model. This study's evidence was collected between Jan 1, 2017 and the conclusion of each database (which ranged from Jul 2020 to May 2022). The 16 pre-specified prevalent AESIs were: acute myocardial infarction, anaphylaxis, appendicitis, Bell's palsy, deep vein thrombosis, disseminated intravascular coagulation, encephalomyelitis, Guillain- Barré syndrome, haemorrhagic stroke, non-haemorrhagic stroke, immune thrombocytopenia, myocarditis/pericarditis, narcolepsy, pulmonary embolism, transverse myelitis, and thrombosis with thrombocytopenia. Age-sex standardised incidence rate ratios (SIR) were estimated to compare post-COVID-19 to pre-pandemic rates in each of the databases.Substantial heterogeneity by age was seen for AESI rates, with some clearly increasing with age but others following the opposite trend. Similarly, differences were also observed across databases for same health outcome and age-sex strata. All studied AESIs appeared consistently more common in the post-COVID-19 compared to the historical cohorts, with related meta-analytic SIRs ranging from 1.32 (1.05 to 1.66) for narcolepsy to 11.70 (10.10 to 13.70) for pulmonary embolism.Our findings suggest all AESIs are more common after COVID-19 than in the general population. Thromboembolic events were particularly common, and over 10-fold more so. More research is needed to contextualise post-COVID-19 complications in the longer term.None.
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| 4. |
- Aparicio, Francisco, et al.
(författare)
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Incorporation of luminescent nanometric films in photonic crystals and devices for the development of photonic sensors
- 2010
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Konferensbidrag (refereegranskat)abstract
- Dye molecules embedded in different matrices in the form of thin films are the basis of specific materials used for laser cavities, optical filters, optical gas sensors, etc. In the present communication we discuss a new methodology based on the remote microwave plasma assisted deposition of dye containing thin films that circumvent the above mentioned problems. It permits a tailored synthesis of optically active nanometric thin films containing dye molecules which are active as fluorescence emitters (i.e., coloured and fluorescent films). The principle of this new procedure is the partial polymerization of dye molecules that are evaporated over a substrate while exposed to a remote microwave Ar plasma. As a result of this process a polymeric thin film is produced in one step where some dye molecules keep intact their optical activity (although eventually, their optical response can be slightly modified by matrix effects). This methodology has been recently used for the deposition of novel plasma nanocomposites containing non-aggregated laser dyes to maximize the fluorescent emission of the materials and for the fabrication of optical NO2 sensing nanocomposites. To illustrate the possibilities of the technique we present here results for different fluorescent dye molecules, as perylene dyes, and several xanthene and oxazine derivative cationic dyes which are typically used as gain media in tuneable laser dyes. The luminescent, optical and sensing properties of these dye containing nanocomposites will be presented. These active optical layers are being developed for the fabrication of photonic sensor devices, optical filters and photonic chips (PHODYE EU Project). This is due to the full compatibility of the synthetic methodology with the present integrated microelectronic and optoelectronic technology. The possibilities for the fabrication of photonic devices integrating these active optical layers will be demonstrated. Especial attention will be paid to recent results about the incorporation of the luminescent films in photonic crystals and about the conformal growth of luminescent planar defects within artificial opals.
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| 5. |
- Aparicio, Francisco J., et al.
(författare)
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Dye-based photonic sensing systems
- 2016
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 228, s. 649-657
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Tidskriftsartikel (refereegranskat)abstract
- We report on dye-based photonic sensing systems which are fabricated and packaged at wafer scale. For the first time luminescent organic nanocomposite thin-films deposited by plasma technology are integrated in photonic sensing systems as active sensing elements. The realized dye-based photonic sensors include an environmental NO2 sensor and a sunlight ultraviolet light (UV) A+B sensor. The luminescent signal from the nanocomposite thin-films responds to changes in the environment and is selectively filtered by a photonic structure consisting of a Fabry-Perot cavity. The sensors are fabricated and packaged at wafer-scale, which makes the technology viable for volume manufacturing. Prototype photonic sensor systems have been tested in real-world scenarios. (C) 2016 Elsevier B.V. All rights reserved.
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| 6. |
- Aparicio, Francisco J., et al.
(författare)
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Transparent Nanometric Organic Luminescent Films as UV-Active Components in Photonic Structures
- 2011
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 23:6, s. 761-765
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Tidskriftsartikel (refereegranskat)abstract
- A new kind of visible-blind organic thin-film material, consisting of a polymeric matrix with a high concentration of embedded 3-hydroxyflavone (3HF) dye molecules, that absorbs UV light and emits green light is presented. The thin films can be grown on sensitive substrates, including flexible polymers and paper. Their suitability as photonic active components in photonic devices is demonstrated.
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| 8. |
- Barrios, Carlos, et al.
(författare)
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Integrated Si3N4/SiO2 Slot-Waveguide Microresonators
- 2007
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Konferensbidrag (refereegranskat)abstract
- We demonstrate slot-waveguide microring resonators and Fabry-Perot microcavities on Si3N4/SiO2. Characterization indicates guiding and confinement in the waveguide nanometric-size low-index slot region at O-band (1260-1370nm) wavelengths. We measured propagation losses <20 dB/cm.
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| 12. |
- Hernandez-Garcia, C., et al.
(författare)
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Carrier-envelope-phase insensitivity in high-order harmonic generation driven by few-cycle laser pulses
- 2015
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Ingår i: Optics Express. - 1094-4087. ; 23:16, s. 21497-21508
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Tidskriftsartikel (refereegranskat)abstract
- We present evidence for self-stabilization of the relative spectral phase of high-order harmonic emission against intensity variations of the driving field. Our results demonstrate that, near the laser focus, phase matching of the harmonic field from a macroscopic target can compensate for the intensity dependence of the intrinsic phase of the harmonics emitted by a single radiator. As a consequence, we show experimentally and theoretically the insensitivity of the harmonic spectra produced at the laser focus against variations of the carrier-envelope phase (CEP) of a sub-two-cycle driving field. In addition, the associated attosecond pulse trains exhibit phase locking against CEP changes of the few-cycle driver. (C) 2015 Optical Society of America
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| 13. |
- Holgado, W., et al.
(författare)
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Continuous spectra in high-harmonic generation driven by multicycle laser pulses
- 2016
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 93:1
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Tidskriftsartikel (refereegranskat)abstract
- We present observations of the emission of XUV continua in the 20-37-eV region by high-harmonic generation with 4-7-fs pulses focused onto a Kr gas jet. The underlying mechanism relies on coherent control of the relative delays and phases between individually generated attosecond pulses, achievable by adjusting the chirp of the driving pulses and the interaction geometry. Under adequate negative chirp and phase-matching conditions, the resulting interpulse interference yields a continuum XUV spectrum, which is due to both microscopic and macroscopic (propagation) contributions. This technique opens the route for modifying the phase of individual attosecond pulses and for the coherent synthesis of XUV continua from multicycle driving laser pulses without the need of an isolated attosecond burst.
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