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Sökning: WFRF:(Holmberg Benny)

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1.
  • André, Benny (författare)
  • Nanocomposites for Use in Sliding Electrical Contacts
  • 2011
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In this thesis nanocomposite materials for use in high performance electrical contacts are tested. Self mating silver as coatings on cupper substrates are the most used material combination in power connectors today. In this work two new concepts were tested. The first one was to change one of the mating surfaces to a hard thin coating and keep the other surface made of silver. Tested coatings were nanocomposites with hard carbides in a matrix of amorphous carbon. TiC/a-C and  Ti-Ni-C/a-C were tested both electrically and tribologically. The total amount of carbon and the amount of carbon matrix was important, both for the electrical and the tribological properties. The Ti-Ni-C coating also showed that substituting Ti in TiC with the weak carbide former Ni changed the stability of the carbides. The substitution resulted in more a-C matrix and less C in the carbides. Thin coatings of nc-TiC/a-C and  Ti-Ni-C/a-C showed high potential as material candidates for use in electrical contacts. The other tested concept was to modify the used silver instead of replacing it. This was done by embedding nanoparticles of solid lubricant IF-WS2 in the silver. The results from reciprocating sliding displayed low friction and high wear resistance. The modified silver surfaces lasted for 8000 strokes with a friction of about 0.3 while at the same time allowing for a low contact resistance. The results for surfaces of pure silver coating displayed a friction of 0.8-1.2 and that the silver was worn through already after 300 strokes. A new method to investigate inherent hardness and residual stress of thin coatings, on complex geometries or in small areas, was also developed. An ion beam was used to create stress free coating as free standing micro pillars. Hardness measured on the pillars and on as-deposited coating were then used to calculate the residual stress in the coatings.
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2.
  • Broomé, Per, et al. (författare)
  • Do defining moments leave their mark for life? : the case of Sweden
  • 2011
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • According to the theory of “defining moments” dramatic events such as the assassination of John F. Kennedy in 1963 and the 9/11 terrorist attacks in 2001 make a deep impression especially on the minds of young people and eventually lead to the formation of cohorts bound by common values. Knowledge of such cohorts can be used for many purposes, such as marketing, staff management or political campaigns. This paper analyses the impact of dramatic events on people in different age groups in Sweden through a survey answered by nearly a thousand people – of which 40 percent are foreign-born – from the city of Malmö.
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4.
  • Carlson, Benny, et al. (författare)
  • Integration pågår
  • 2010
  • Ingår i: I & M. - 1404-6857. ; 37:2, s. 37-41
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Medan unga malmöbor ofta möts över kulturgränser, träffar knappt varannan sjuttioåring någon från en annan kultur. Även om utrymmet för mångfald tycks ha sina gränser och attityderna är polariserade, får ytterligheterna allt svagare stöd.
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5.
  • Holmberg, Benny, 1958- (författare)
  • Analysis of risk factors in patients with severe chronic kidney disease. The role of atorvastatin.
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Background and aim: There had been no randomized end-point studies with statins for patients with severe renal failure. The purpose of this prospective, open, randomized, controlled study was to investigate whether atorvastatin (10 mg/day) would alter cardiovascular end-points and the overall mortality rate of patients with chronic kidney disease stage 4 or 5 (creatinine clearanceMaterial & Methods: This was an open, prospective, randomized study. A total of 143 patients were included: 73 were controls and 70 were prescribed 10 mg/day of atorvastatin. As efficacy variables, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride levels were determined at the start of the study and at 1, 3, 6, 12, 18, 24, 30 and 36 months. The primary end-points were all cause of mortality, non-lethal acute myocardial infarction, and coronary artery intervention. Various risk factors were studied. In the 97 patients on haemodialysis inter dialysis weight gain (IDWG) was calculated as ultrafiltration in kg/body weight in kg given in percentage of the weight. The burden of IDWG was analyzed.Results: In the atorvastatin group, total cholesterol and low-density lipoprotein cholesterol were significantly reduced, the latter by 35% at 1 month and then sustained. Atorvastatin was withdrawn in 23% of patients due to unacceptable side effects, most frequent complaints being gastrointestinal discomfort and headache. Primary end-points occurred in 74% of the subjects. There was no difference in cardiovascular endpoint and survival between the control and atorvastatin groups. The 5-year end-point-free survival rate from study entry was 20%. There was no evidence of more benefit of atorvastatin for patients with diabetes mellitus and chronic kidney disease versus the other patients; instead plasma fibrinogen increased. The IDWG was significantly larger in patients who suffered from end-points due to cardiovascular reasons, cardiac reasons, congestive heart failure, aortic aneurysm, and intracerebral bleeding.Conclusion: These data showed that in contrast to other patient groups, patients with severe chronic kidney disease 4 and 5, including those with diabetes mellitus, seem to have no benefit from 10mg/day of atorvastatin. Instead we found a high IDWG to be an important risk factor that should be prevented. There was no evident connection between atorvastatin medication and IDWG.
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6.
  • Holmberg, Benny, et al. (författare)
  • Cardiovascular conditions in hemodialysis patients may be worsened by extensive interdialytic weight gain
  • 2009
  • Ingår i: Hemodialysis International. - : Wiley. - 1492-7535 .- 1542-4758. ; 13:1, s. 27-31
  • Tidskriftsartikel (refereegranskat)abstract
    • The risk of death is increased for hemodialysis (HD) patients compared with age-matched healthy subjects, the main reason for this being cardiovascular conditions. This prospective study investigated whether the burden of interdialytic weight gain (IDWG) was of importance for cardiovascular end points and survival. A total of 97 HD patients were studied. The end points included death (reasons given), acute myocardial infarction, or coronary vascular intervention. The extent of ultrafiltration was measured at predefined follow-up points. The IDWG was calculated as ultrafiltration/body weight given in weight%. The burden of IDWG was analyzed. End points occurred in 77 (79%) of the patients during the 5-year study period. The extent of IDWG was higher in those with end points due to cardiovascular reasons (3.77 weight% vs. 3.19 P<0.001), cardiac reasons (P<0.001), congestive heart failure (P<0.01), aortic aneurysm, and intracerebral bleeding (P<0.024). To reduce the risk for cardiovascular events, it is important to avoid too extensive IDWG in HD patients.
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10.
  • Stegmayr, Bernd, et al. (författare)
  • Low-dose atorvastatin in severe chronic kidney disease patients : a randomized, controlled endpoint study
  • 2005
  • Ingår i: Scandinavian Journal of Urology and Nephrology. - 0036-5599 .- 1651-2065. ; 39:6, s. 489-497
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective. There have been no endpoint studies with statins for patients with severe renal failure. The purpose of this prospective, open, randomized, controlled study was to investigate whether atorvastatin (10 mg/day) would alter cardiovascular endpoints and the overall mortality rate of patients with chronic kidney disease stage 4 or 5 (creatinine clearance < 30 ml/min).Material and methods. The study subjects comprised 143 patients who were randomized either to placebo (controls; n=73; mean age 69.5 years) or to treatment with atorvastatin (n=70; mean age 67.9 years). The patients included were either non-dialysis (n=33), haemodialysis (n=97) or peritoneal dialysis (n=13) patients. Analysis focused on the primary endpoints of all-cause mortality, non-lethal acute myocardial infarction, coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty. Statistical analysis for endpoint data was mainly by intention-to-treat.Results. Primary endpoints occurred in 74% of the subjects. There was no difference in outcome between the control and atorvastatin groups. The 5-year endpoint-free survival rate from study entry was 20%. Atorvastatin was withdrawn in 20% of patients due to unacceptable side-effects. In the atorvastatin group, low-density lipoprotein (LDL) cholesterol was reduced by 35% at 1 month and then sustained. The controls showed a progressive reduction in LDL cholesterol until 36 months.Conclusions. Although atorvastatin reduced total and LDL cholesterol effectively it was not beneficial regarding the long-term outcomes of cardiovascular endpoints or survival. In contrast to other patient groups, patients with severe chronic kidney disease, especially those on dialysis, seem to derive limited benefit from this lower dose of atorvastatin.
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