| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
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| 3. |
- Bladh, Kent, et al.
(författare)
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Enhanced Bayesian THERP : Experience from HRA method evaluation
- 2010
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Ingår i: Proceedings of European Safety and Reliability, ESREL 2010. - London : Taylor & Francis Group.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The Enhanced Bayesian THERP (Technique for Human Reliability Analysis) method uses as its basis the time-reliability curve introduced in the Swain’s human reliability analysis (HRA) handbook. It differs from the Swain's Handbook via a transparent adjustment of the time-dependent human error probabilities by use of five performance shaping factors (PSFs): (1) support from procedures, (2) support from training, (3) feedback from process, (4) need for co-ordination and communication, (5) mental load, decision burden. In order to better know the characteristics of the Enhanced Bayesian THERP from a more international perspective, the method has been subject to evaluation within the framework of the international “HRA Methods Empirical Study Using Simulator Data”. Without knowledge of the crews’ performances, several HRA analysis teams from different countries, using different methods, performed predictive analyses of four scenarios. This paper gives an overview of the method with major findings from the benchmarking. The empirical comparison gives confidence that the time reliability curve is a feasible and cost effective method to estimate human error probabilities when the time window is well defined and relatively short. The comparison of empirical observations with predictions was found as an useful exercise to identify areas of improvements in the HRA method.
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| 4. |
- Bonander, Carl, 1988-, et al.
(författare)
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Model-based economic evaluation of ice cleat distribution programmes for the prevention of outdoor falls among adults from a Swedish societal perspective
- 2022
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Ingår i: Injury Prevention. - : BMJ Publishing Group Ltd. - 1353-8047 .- 1475-5785. ; 28:2, s. 125-130
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Tidskriftsartikel (refereegranskat)abstract
- Background: Slipping on snow or ice poses a significant health risk among older adults in Sweden. To combat this problem, about 80 Swedish municipalities have distributed ice cleats to older citizens (65+ years old) over the last decade. This paper details a cost-benefit analysis of such programmes. Materials and methods: We developed a decision-analytical model to estimate the costs and benefits of ice cleat programmes in Swedish municipalities compared with a business-as-usual scenario. The modelled benefits of the programme were based on effect estimates from previous research, data from population and healthcare registers and a survey of attitudes to and actual ice cleat use. The modelled costs of the programme were based on resource use data collected from 34 municipalities with existing ice cleat programmes. We assessed heterogeneity in the potential impact and benefit-to-cost ratios across all Swedish municipalities as a function of the average number of days with snow cover per year. Uncertainty in the cost-benefit results was assessed using deterministic and probabilistic sensitivity analyses. Results: The average benefit-to-cost ratio was 87, ranging from about 40 in low-risk municipalities to 140 in high-risk municipalities, implying that the potential benefits of ice cleat programmes greatly outweigh their costs. Probabilistic and deterministic sensitivity analyses support the robustness of this conclusion to parameter uncertainty and large changes in assumptions about the magnitude of the impact on ice cleat use and injuries. Conclusion: The benefits of distributing ice cleats to older adults appear to outweigh the costs from a Swedish societal perspective.
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| 5. |
- Buervenich, Silvia, et al.
(författare)
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A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.
- 2005
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Ingår i: Archives of neurology. - : American Medical Association (AMA). - 0003-9942. ; 62:1, s. 74-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Alcohol dehydrogenases (ADHs) may be involved in the pathogenesis of neurodegenerative disorders because of their multiple roles in detoxification pathways and retinoic acid synthesis. In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample. PATIENTS: The previously associated single-nucleotide polymorphism plus 12 further polymorphisms in the ADH cluster on human chromosome 4q23 were screened for association in an extension of the original sample that now included 123 Swedish PD patients and 127 geographically matched control subjects. A rare nonsense single-nucleotide polymorphism in ADH1C (G78stop, rs283413) was identified in 3 of these patients but in no controls. To obtain sufficient power to detect a possible association of this rare variant with disease, we screened a large international sample of 1076 PD patients of European ancestry and 940 matched controls. RESULTS: The previously identified association with an ADH class IV allele remained significant (P<.02) in the extended Swedish study. Furthermore, in the international collaboration, the G78stop mutation in ADH1C was found in 22 (2.0%) of the PD patients but only in 6 controls (0.6%). This association was statistically significant (chi(2)(1) = 7.5; 2-sided P = .007; odds ratio, 3.25 [95% confidence interval, 1.31-8.05]). In addition, the G78stop mutation was identified in 4 (10.0%) of 40 Caucasian index cases with PD with mainly hereditary forms of the disorder. CONCLUSION: Findings presented herein provide further evidence for mutations in genes encoding ADHs as genetic risk factors for PD.
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| 6. |
- Cheng, Arthur J., et al.
(författare)
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Post-exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle
- 2017
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Ingår i: Journal of Physiology. - : John Wiley & Sons. - 0022-3751 .- 1469-7793. ; 595:24, s. 7413-7426
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Tidskriftsartikel (refereegranskat)abstract
- Key points: We investigated whether intramuscular temperature affects the acute recovery of exercise performance following fatigue-induced by endurance exercise. Mean power output was better preserved during an all-out arm-cycling exercise following a 2 h recovery period in which the upper arms were warmed to an intramuscular temperature of ˜ 38°C than when they were cooled to as low as 15°C, which suggested that recovery of exercise performance in humans is dependent on muscle temperature. Mechanisms underlying the temperature-dependent effect on recovery were studied in intact single mouse muscle fibres where we found that recovery of submaximal force and restoration of fatigue resistance was worsened by cooling (16-26°C) and improved by heating (36°C). Isolated whole mouse muscle experiments confirmed that cooling impaired muscle glycogen resynthesis. We conclude that skeletal muscle recovery from fatigue-induced by endurance exercise is impaired by cooling and improved by heating, due to changes in glycogen resynthesis rate.Manipulation of muscle temperature is believed to improve post-exercise recovery, with cooling being especially popular among athletes. However, it is unclear whether such temperature manipulations actually have positive effects. Accordingly, we studied the effect of muscle temperature on the acute recovery of force and fatigue resistance after endurance exercise. One hour of moderate-intensity arm cycling exercise in humans was followed by 2 h recovery in which the upper arms were either heated to 38°C, not treated (33°C), or cooled to ∼15°C. Fatigue resistance after the recovery period was assessed by performing 3 × 5 min sessions of all-out arm cycling at physiological temperature for all conditions (i.e. not heated or cooled). Power output during the all-out exercise was better maintained when muscles were heated during recovery, whereas cooling had the opposite effect. Mechanisms underlying the temperature-dependent effect on recovery were tested in mouse intact single muscle fibres, which were exposed to ∼12 min of glycogen-depleting fatiguing stimulation (350 ms tetani given at 10 s interval until force decreased to 30% of the starting force). Fibres were subsequently exposed to the same fatiguing stimulation protocol after 1-2 h of recovery at 16-36°C. Recovery of submaximal force (30 Hz), the tetanic myoplasmic free [Ca2+] (measured with the fluorescent indicator indo-1), and fatigue resistance were all impaired by cooling (16-26°C) and improved by heating (36°C). In addition, glycogen resynthesis was faster at 36°C than 26°C in whole flexor digitorum brevis muscles. We conclude that recovery from exhaustive endurance exercise is accelerated by raising and slowed by lowering muscle temperature.
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| 7. |
- Dubbelboer, Ilse R, et al.
(författare)
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Gastrointestinal mucus in dog : Physiological characteristics, composition, and structural properties
- 2022
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Ingår i: European journal of pharmaceutics and biopharmaceutics. - : Elsevier. - 0939-6411 .- 1873-3441. ; 173, s. 92-102
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Tidskriftsartikel (refereegranskat)abstract
- Gastrointestinal (GI) mucus is continuously secreted and lines the entire length of the GI tract. Essential for health, it keeps the noxious luminal content away from the epithelium. Our aim was to characterize the composition and structure of mucus throughout the various GI segments in dog.Mucus was collected from the stomach, small intestine (duodenum, jejunum, ileum), and large intestine (cecum, proximal and distal colon) from dogs. Composition was determined by multi-omics. Structural properties were investigated using cryoSEM and rheology.GI mucus contained 74-95% water and maintained a pH around 6.5. The proteome was similar across the different GI segments. The highest abundant secreted gel-forming mucin in the gastric mucus was mucin 5AC, whether mucin 2 had highest abundance in the intestinal mucus. Lipid and metabolite abundance was generally higher in the jejunal mucus than the colonic mucus. CryoSEM microscopy revealed smaller pore size in small intestinal mucus, which increased in the large intestine. All mucus samples showed shear-thinning behavior and characteristics of gel-like structure.In conclusion, the mucus is a highly viscous and hydrated material. These data provide an important baseline for future studies on human and canine intestinal diseases and the dog model in drug absorption.
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| 8. |
- Eklund, Elin, 1992, et al.
(författare)
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Quasi-experimental evaluation of municipal ice cleat distribution programmes for older adults in Sweden
- 2023
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Ingår i: Injury Prevention. - : BMJ Publishing Group Ltd. - 1353-8047 .- 1475-5785. ; 29:5, s. 378-83
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionFall injuries caused by icy road conditions are a prevalent public health problem during winters in Sweden, especially in older populations. To combat this problem, many Swedish municipalities have distributed ice cleats to older adults. While previous research has shown promising results, there is a lack of comprehensive empirical data on the effectiveness of ice cleat distribution. We address this gap by investigating the impact of these distribution programmes on ice-related fall injuries among older adults. MethodsWe combined survey data on ice cleat distribution in Swedish municipalities with injury data from the Swedish National Patient Register (NPR). The survey was used to identify municipalities that have distributed ice cleats to older adults at some point between 2001 and 2019. Data from NPR were used to identify municipality-level data on patients who have been treated for injuries related to snow and ice. We used a triple differences design-a generalisation of difference in differences-that compared ice-related fall injury rates before and after intervention in 73 treatment and 200 control municipalities, with unexposed age groups serving as within-municipality controls. ResultsWe estimate that the average ice cleat distribution programmes reduced ice-related fall injury rates by -0.24 (95% CI -0.49 to 0.02) per 1000 person-winters. The impact estimate was larger in municipalities that distributed more ice cleats (-0.38 (95% CI -0.76 to -0.09)). No similar patterns were found for fall injuries unrelated to snow and ice. ConclusionOur results suggest that ice cleat distribution can decrease the incidence of ice-related injuries among older adults.
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| 9. |
- Ferrari, Desiree, et al.
(författare)
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Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions
- 2022
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Ingår i: Theriogenology. - : Elsevier. - 0093-691X .- 1879-3231. ; 181, s. 59-68
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Tidskriftsartikel (refereegranskat)abstract
- Pain treatment of lactating bitches is a clinically relevant, but complicated issue. Published scientific studies regarding the excretion of drugs in canine milk are scarce. When considering the risk of side effects in their offspring, lactating bitches have traditionally received very restricted analgesic and anti-inflammatory therapy. Our aim was to quantify the concentrations of carprofen in milk from lactating bitches and relate those to potential risks for the puppies. A second aim was to evaluate the impact mastitis may have on the concentration of carprofen in milk. A population of 100 bitches was enrolled in the study, among which 88 were bitches treated with carprofen after cesarean section (Group CS), eight were bitches with painful inflammatory conditions (Group I) and four were bitches with mastitis (Group M). The patients enrolled in the study received carprofen 4 mg/kg sc at day 1 followed by 2 mg/kg po every 12 h for the following 2-5 days. Owners were instructed to collect milk once a day for five days. The concentration of carprofen in the milk was quantified with ultra-performance liquid chromatography-tandem mass spectrometry. The data obtained were statistically analyzed as repeated-measures data with a mixed-model approach. Data were used to calculate the theoretical maximum total daily intake of carprofen by the puppies in order to perform a computerized simulation of the plasma concentration of carprofen in the puppies. Follow-up telephone interviews to check the status of the enrolled bitches and their litters occurred at one week and three-six months after treatment with car-profen. The major finding of the study was that the concentration of carprofen in the milk was <700 ng/ mL from bitches undergoing CS or suffering painful conditions other than mastitis. In comparison, administration of 2 mg/kg of carprofen sc or po to adult dogs, results in mean maximal plasma con-centrations of 19480 +/- 5420 ng/mL (mean +/- SD). Moreover, data suggests that inflammation of the mammary gland results in a higher concentration of carprofen in milk (up to 1300 ng/mL). In the computerized simulation, the plasma concentrations of carprofen in puppies in group CS and in group I are one tenth of the concentration in adult dogs receiving carprofen at standard doses. Considering the low excretion into milk, carprofen provides an analgesic alternative to lactating bitches without mastitis.(c) 2022 Published by Elsevier Inc.
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| 10. |
- Gulyas, Miklos, et al.
(författare)
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COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer.
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Tidskriftsartikel (refereegranskat)abstract
- Inhibition of cyclooxygenase-2 (COX-2) is proposed as a treatment option in several cancer types. However, in non-small cell lung cancer (NSCLC), phase III trials have failed to demonstrate a benefit of adding COX-2 inhibitors to standard chemotherapy. The aim of this study was to analyse COX-2 expression in tumor and stromal cells as predictive biomarker for COX-2 inhibition.Methods: In the multicenter phase III trial, 316 patients with advanced NSCLC were randomized to receive celecoxib (400 mg b.i.d.) or placebo up to one year in addition to a two-drug platinum-based chemotherapy combination. In a subset of 122 patients, archived tumor tissue was available for immunohistochemical analysis of COX-2 expression in tumor and stromal cells.Results: An updated analysis of all 316 patients included in the original trial, and of the 122 patients with available tumor tissue, showed no survival differences between the celecoxib and placebo arms (HR 1.01; 95%CI 0.81-1.27 and HR 1.12; 95%CI 0.78-1.61, respectively). Similarly, in patients with high COX-2 expression in tumor cells (n=71) or stromal cells (n=55), survival did not differ significantly between patients who received celecoxib or placebo (HR 1.07; 95%CI 0.74-1.54 and HR 0.80; 95%CI 0.56-1.15). No significant interaction effect between COX-2 score in tumor or stromal cells and celecoxib effect on survival was detected (p=0.48 and 0.25, respectively).Conclusion: In this subgroup analysis of patients with advanced NSCLC, we could not detect any significant interaction between COX-2 expression in tumor or stromal cells and outcome of celecoxib treatment in addition to standard chemotherapy.
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| 11. |
- Gulyas, Miklos, et al.
(författare)
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COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer.
- 2018
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 57:2, s. 244-250
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Inhibition of cyclooxygenase-2 (COX-2) is proposed as a treatment option in several cancer types. However, in non-small cell lung cancer (NSCLC), phase III trials have failed to demonstrate a benefit of adding COX-2 inhibitors to standard chemotherapy. The aim of this study was to analyze COX-2 expression in tumor and stromal cells as predictive biomarker for COX-2 inhibition.Methods: In a multicenter phase III trial, 316 patients with advanced NSCLC were randomized to receive celecoxib (400 mg b.i.d.) or placebo up to one year in addition to a two-drug platinum-based chemotherapy combination. In a subset of 122 patients, archived tumor tissue was available for immunohistochemical analysis of COX-2 expression in tumor and stromal cells. For each compartment, COX-2 expression was graded as high or low, based on a product score of extension and intensity of positively stained cells.Results: An updated analysis of all 316 patients included in the original trial, and of the 122 patients with available tumor tissue, showed no survival differences between the celecoxib and placebo arms (HR 1.01; 95% CI 0.81–1.27 and HR 1.12; 95% CI 0.78–1.61, respectively). High COX-2 scores in tumor (n = 71) or stromal cells (n = 55) was not associated with a superior survival outcome with celecoxib vs. placebo (HR =0.96, 95% CI 0.60–1.54; and HR =1.51; 95% CI 0.86–2.66), and no significant interaction effect between COX-2 score in tumor or stromal cells and celecoxib effect on survival was detected (p = .48 and .25, respectively).Conclusions: In this subgroup analysis of patients with advanced NSCLC treated within the context of a randomized trial, we could not detect any interaction effect of COX-2 expression in tumor or stromal cells and the outcome of celecoxib treatment in addition to standard chemotherapy.
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| 12. |
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| 13. |
- Hederus, Sanna, et al.
(författare)
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Keramiska väggmaterial i offentlig miljö : Forskningsrapport
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Ett konstnärligt forskningsprojekt inom ramen för KRC (Keramiskt Resurscentrum) på Konstfack, med utgångspunkt i Stockholms tunnelbana. Projektets målsättning har varit att bedriva en praktisk och teoretisk forskning kring design och keramiska materials användning i offentlig miljö. Projektet är utformat som ett tvärvetenskapligt samarbete mellan deltagarna i projektgruppen. I projektgruppen ingår; Sanna Hederus, arkitekt Johanna Karlin, konstnär Gustaf Nordenskiöld, keramiker Anna Westholm, industridesigner Projektledare och redaktörer; Katarina Andersson och Helena Holmberg Projektet har möjliggjorts genom ett samarbete med SL, CC Höganäs, Gatu- och Fastighetskontoret i Stockholms kommun och Byggkeramikrådet.
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| 14. |
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| 15. |
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| 16. |
- Holmberg, Johanna, et al.
(författare)
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Decompressional equilibration of the Midsund granulite from Otrøy, Western Gneiss Region, Norway
- 2019
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Ingår i: Geologica Carpathica. - Bratislava : Slovak Acdemy of Sciences. - 1335-0552 .- 1336-8052. ; 70:6, s. 471-482
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Tidskriftsartikel (refereegranskat)abstract
- The Western Gneiss Region (WGR) of the Scandinavian Caledonides is an archetypal terrain for high-pressure(HP) and ultrahigh-pressure (UHP) metamorphism. However, the vast majority of lithologies occurring there bear no,or only limited, evidence for HP or UHP metamorphism. The studied Midsund HP granulite occurs on the island of Otrøy,a locality known for the occurrence of the UHP eclogites and mantle-derived, garnet-bearing ultramafics. The Midsundgranulite consists of plagioclase, garnet, clinopyroxene, relict phengitic mica, biotite, rutile, quartz, amphibole, ilmeniteand titanite, among the most prominent phases. Applied thermodynamic modelling in the NCKFMMnASHT systemresulted in a pressure–temperature (P–T) pseudosection that provides an intersection of compositional isopleths ofXMg (Mg/Mg+Fe) in garnet, albite in plagioclase and XNa (Na/Na+Ca) in clinopyroxene in the stability field of melt +plagioclase + garnet + clinopyroxene + amphibole + ilmenite. The obtained thermodynamic model yields P–T conditions of1.32–1.45 GPa and 875–970 °C. The relatively high P–T recorded by the Midsund granulite may be explained as an effectof equilibration due to exhumation from HP (presumably UHP) conditions followed by a period of stagnation under HTat lower-to-medium crustal level. The latter seems to be a more widespread phenomenon in the WGR than previouslythought and may well explain commonly calculated pressure contrasts between neighboring lithologies in the WGR andother HP–UHP terranes worldwide.
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| 17. |
- Holmberg, Jan-Erik, 1964-, et al.
(författare)
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Enhanced Bayesian THERP : Lessons learnt from HRA benchmarking
- 2010
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Ingår i: Proc. of PSAM 10 — International Probabilistic Safety Assessment & Management Conference, 7–11 June 2010, Seattle, Washington, USA, IAPSAM — International Association of Probabilistic Safety Assessment and Management. - : International Association for Probabilistic Safety Assessment and Managemen. ; , s. 52-
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Konferensbidrag (refereegranskat)abstract
- The Enhanced Bayesian THERP (Technique for Human Reliability Analysis) method usesas its basis the time-reliability curve introduced in the Swain’s human reliability analysis (HRA)handbook. It differs from the Swain's Handbook via a transparent adjustment of the time-dependenthuman error probabilities by use of five performance shaping factors (PSFs): (1) support fromprocedures, (2) support from training, (3) feedback from process, (4) need for co-ordination andcommunication, (5) mental load, decision burden. In order to better know the characteristics of theEnhanced Bayesian THERP from a more international perspective, the method has been subject toevaluation within the framework of the international “HRA Methods Empirical Study Using SimulatorData”. Without knowledge of the crews’ performances, several HRA analysis teams from differentcountries, using different methods, performed predictive analyses of four scenarios. This paper givesan overview of the method with major findings from the benchmarking. The empirical comparisongives confidence that the time reliability curve is a feasible and cost effective method to estimatehuman error probabilities when the time window is well defined and relatively short. The comparisonof empirical observations with predictions was found as a useful exercise to identify areas ofimprovements in the HRA method.
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| 18. |
- Holmberg, Lars, et al.
(författare)
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Increased risk of recurrence after hormone replacement therapy in breast cancer survivors
- 2008
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 100:7, s. 475-482
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Hormone replacement therapy (HT) is known to increase the risk of breast cancer in healthy women, but its effect on breast cancer risk in breast cancer survivors is less clear. The randomized HABITS study, which compared HT for menopausal symptoms with best management without hormones among women with previously treated breast cancer, was stopped early due to suspicions of an increased risk of new breast cancer events following HT. We present results after extended follow-up. METHODS: HABITS was a randomized, non-placebo-controlled noninferiority trial that aimed to be at a power of 80% to detect a 36% increase in the hazard ratio (HR) for a new breast cancer event following HT. Cox models were used to estimate relative risks of a breast cancer event, the maximum likelihood method was used to calculate 95% confidence intervals (CIs), and chi(2) tests were used to assess statistical significance, with all P values based on two-sided tests. The absolute risk of a new breast cancer event was estimated with the cumulative incidence function. Most patients who received HT were prescribed continuous combined or sequential estradiol hemihydrate and norethisterone. RESULTS: Of the 447 women randomly assigned, 442 could be followed for a median of 4 years. Thirty-nine of the 221 women in the HT arm and 17 of the 221 women in the control arm experienced a new breast cancer event (HR = 2.4, 95% CI = 1.3 to 4.2). Cumulative incidences at 5 years were 22.2% in the HT arm and 8.0% in the control arm. By the end of follow-up, six women in the HT arm had died of breast cancer and six were alive with distant metastases. In the control arm, five women had died of breast cancer and four had metastatic breast cancer (P = .51, log-rank test). CONCLUSION: After extended follow-up, there was a clinically and statistically significant increased risk of a new breast cancer event in survivors who took HT.
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| 19. |
- Holmberg Larsson, Jakob, et al.
(författare)
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Regional variations in Sweden over time regarding the surgical treatment of acute cholecystitis: a population-based register study
- 2022
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Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 57:3, s. 305-310
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To provide optimal health care for patients with acute cholecystitis in need of acute cholecystectomy, resource allocation has to be optimized. The aim of this study was to assess possible regional inequity regarding the treatment of acute cholecystitis and explore regional differences in the management of acute cholecystitis.Methods: Data were retrieved from the Swedish National Register for Gallstone Surgery and Endoscopic Retrograde CholangioPancreatography. Between January 2010 and December 2019, 22,985 patients who underwent cholecystectomy for acute cholecystitis and without prior history of acute cholecystitis were included in the study. The ratio of cholecystectomies with acute cholecystitis performed within two days of admission to hospital compared to population density was studied. Furthermore, the proportion of acute performed cholecystectomies within two days of admission in regions, with or without tertiary care centers, was also examined.Results: No correlation between population density and proportion of acute performed cholecystectomies was found. Regions without tertiary care centers had a higher proportion of acute cholecystectomies performed within two days (5–10%). The difference in the ratio of acute cholecystectomies within two days of admission was significant for all years investigated except 2010.Conclusions: The presence of a tertiary referral center within the region had a greater influence than the population density on the chance of undergoing acute cholecystectomy for patients with acute cholecystitis. There are several potential explanations for this, one being an interference of the needs of patients requiring tertiary referral center care with the needs of patients in need of acute care surgery.
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| 20. |
- Holmberg, Pär, et al.
(författare)
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Nurses' encounters with children as next of kin to parents with a cancer diagnosis on oncology wards
- 2020
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Ingår i: Nordic journal of nursing research. - : Sage Publications. - 2057-1585 .- 2057-1593. ; 40:1, s. 33-40
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Tidskriftsartikel (refereegranskat)abstract
- It is a challenge for registered nurses (RNs) to meet children and young people who have a parent diagnosed with cancer. These children often suffer from shock, anxiety, outrage, fear and stress. Recent studies indicate that when next of kin have a professional person to talk to, their wellbeing increases. Moreover, when these children are involved in their parent’s care they also begin to trust the nurse caring for their parent. However, there is little known of how nurses respond to a child’s needs. Thus, aim of this study was to describe RNs’ experiences of encounters with children as next of kin to a parent diagnosed with cancer. A qualitative descriptive study based on semi-structured group interviews, with a latent content analysis was carried out. One theme, ‘sense of security’ including three categories ‘balanced meeting’, ‘de-dramatize healthcare’ and ‘learn from one another’ was identified. Beyond the categories, there are six sub-categories: ‘sense of insecurity’, ‘caring approach’, ‘providing information’, ‘participation’, ‘processing and follow-up’ and ‘increased knowledge’. The findings of this study highlight the importance of strengthening the RN's ability to create a caring relationship with children as next of kin.
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| 21. |
- Holmberg, Robin
(författare)
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Evaluation of Swedish Ice Cleat Distribution Programs : From Program Design to Ice Cleat Use
- 2023
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Winter conditions, characterized by snow and lowered temperatures, can make travel by foot difficult. Older adults aged 65 and above are especially at risk of slipping and falling on icy or snowy surfaces. Minor falls can result in severe injuries due to their frailty. Traditional methods of reducing this risk, like plowing or using sand and salt, may not always be effective preventive measures. Several municipalities in Sweden have taken action to combat this issue and introduced subsidized ice cleat distribution programs for older adults. It is unclear how these programs are designed and whether they are effective in promoting the use of ice cleats. This thesis uses a mixed-method approach drawing on data collected from multiple sources to analyze and evaluate the programs. Paper I presents a program theory model, outlining the essential components required for implementing a program and describing the causal connections from the program's introduction and necessary conditions to its anticipated impact. Survey data from intervention municipalities suggest that about 40% of the target group participated by retrieving a pair of devices, and 90% of all ice cleats were eventually distributed. Paper II presents an outcome evaluation suggesting that individuals exposed to a distribution program increase ice cleat use. Analyses of the self-reported data on ice cleat use show an increase of 7.5 percentage points. Estimations suggest that general use could be 17.3% if one pair of cleats were distributed to all eligible citizens. Future research is needed to investigate the programs' effect on fall-related injuries on ice and snow. In addition, in-depth interviews with program policymakers should be considered to provide further insights into the design and implementation of these programs.
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| 22. |
- Holmberg, Robin, 1986-, et al.
(författare)
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Evaluation of the design and implementation of municipal ice cleat distribution programs for the prevention of ice-related fall injuries among older adults in Sweden
- 2021
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 16:6
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Tidskriftsartikel (refereegranskat)abstract
- Introduction The risk for outdoor falls tends to increase during winter due to icy road conditions. Several Swedish municipalities have introduced programs that provide their senior citizens with a pair of ice cleats in an attempt to tackle this problem. In this paper, we perform a process evaluation to identify potential barriers to the success of these programs and analyze the logic of their design. Methods We sent a survey to all 290 Swedish municipalities to collect data on the characteristics of ice cleat distribution programs. We also performed focus-group interviews with older adults to gain insight into their thoughts about ice cleat programs. We synthesized our data with existing literature on ice cleats and behavior change theory to populate a logic model to identify and analyze hidden assumptions and potential flaws using program theory analysis. Results On average, about 40% of the eligible population living in the intervention municipalities collected a pair of ice cleats. While we identified some other, but mostly minor, barriers to implementation, the main barrier appears to be a lack of scale (i.e., insufficient procurement and distribution of ice cleats), as 90% of all purchased ice cleats were eventually distributed. While previous research suggests that ice cleats can decrease injury risks if worn, we find that there is limited evidence on the effects of distribution on ice cleat use. Our interviewees emphasized the potential utility of ice cleats for staying safe and active during winter but stressed that ice cleats need to be user-friendly and of high-quality to increase the likelihood that a distribution program encourages behavior change. Conclusion Existing ice cleat distribution programs appear to have reached a meaningful share of the targeted population. Additional research is required to assess their effects on ice cleat use and injury rates.
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| 23. |
- Holmberg, Robin, et al.
(författare)
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Ice cleat distribution programmes and ice cleat use among older adults: repeated cross-sectional evidence from 63 municipal interventions in Sweden
- 2022
-
Ingår i: Injury Prevention. - : BMJ. - 1353-8047 .- 1475-5785.
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction Ice cleats may help prevent ice-related falls in places with icy roads, but there is limited evidence about the association between ice cleat distribution and ice cleat use. Our study examined the association between Swedish municipal distribution programmes and ice cleat use among older adults (65+ years). Methods We combined data on municipal ice cleat distribution programmes (n=63) with repeated cross-sectional self-reports of ice cleat use in Sweden from 2007, 2010, 2014 and 2018. Respondents (n=63 234) were classified as exposed if they lived in a municipality with a programme, belonged to an eligible age group and responded after distribution (n=2507). Dose-response was assessed using distributed ice cleat pairs per capita (mean: 0.38). Linear probability models were used to estimate probability differences in ice cleat use between exposed and unexposed respondents, adjusting for age, sex, country of birth, education, survey wave and municipality. Ineligible age groups living in programme municipalities, who should be unaffected by ice cleat distribution, were used for bias assessment. Results Exposure to ice cleat distribution programmes was associated with 7.5 percentage points (95% CI 4.2 to 10.9) higher self-reported ice cleat use after confounding adjustment. The association was larger in municipalities that distributed one pair of ice cleats per capita (17.3 percentage points (95% CI 11.2 to 23.4)). No association was found among the ineligible age groups (-2.3 (95% CI -5.5 to 1.0)). Conclusion Distributing ice cleats to older adults may help increase their use of ice cleats in settings with icy road conditions.
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| 24. |
- Holmberg, Robin, et al.
(författare)
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Kommunernas trafiksäkerhetsarbete för oskyddade trafikanter
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Goda förutsättningar för aktiva transporter, som att promenera eller att cykla när vi tar oss till våra destinationer, är viktiga aspekter i den hållbara staden och dessutom något som kan förbättra folkhälsan. Många kommuner har identifierat säkerheten för oskyddade trafikanter som ett problem och arbetat fram vägledande strategier för hur de ska arbeta preventivt med denna trafikantgrupp (SKL, 2015:a)(SKL, 2015:a)(SKL, 2015:a), emellertid varierar åtgärderna bland kommunerna.Syftet med denna studie har varit att identifiera och teoretiskt granska, praktiskt och/eller empiriskt välgrundade interventioner som främjar säkerheten för i första hand cyklister och fotgängare. För att skapa en uppfattning om den rådande situationen har kommuner intervjuats om hur de ser på och arbetar med frågan. Tolv intervjuer genomfördes med kommuner av varierande storlekar spridda över landet och intervjumaterialet bearbetades med kvalitativ innehållsanalys.Resultatet visar att det finns ett starkt engagemang för att främja säkerheten för oskyddade trafikanter, men att arbetet hämmas av bristande systematik, knappa ekonomiska resurser och att även brist på kunskap kan utgöra ett hinder. Hastighetsreducerande åtgärder dominerar som främsta trafiksäkerhetsåtgärd, dock har separering av trafikslagen fått ett större fokus och utbyggnad och underhåll av GC-vägar prioriteras.Det framstår som att en systematisk och genomtänkt planering förtydligar målen och ger trafiksäkerhetsarbetet en tydligare inriktning för samtliga kommuner, oavsett storlek. Förutom det så kan ett fortsatt steg för att främja säkerheten för oskyddade trafikanter och samtidigt skapa bättre förutsättningar för aktiv transport vara att tydliggöra indikatorerna för uppföljning av trafiksäkerheten mot skyddade trafikanter.
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| 25. |
- Jar-Allah, Tagrid, et al.
(författare)
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Abnormal cervical cytology is associated with preterm delivery: A population based study
- 2019
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 98:6, s. 777-786
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Increasing evidence suggests that cervical intraepithelial neoplasia, with or without subsequent treatment, is associated with preterm delivery. We aimed to explore the association between abnormal cervical cytology of different severity and the subsequent obstetric outcomes such as preterm delivery. Material and methods: The historical register-based cohort study comprised 19822 women in the Western Region of Sweden who had at least one abnormal cervical cytology from 1978 to 2012 before the age of 45 and a subsequent singleton delivery. The reference group comprised 39644 women with normal cervical cytology and a subsequent singleton delivery, matched by age and parity. Data were retrieved from the Swedish National Cervical Screening Registry, linked to the Swedish Medical Birth Register and Statistic Sweden. The study outcomes were spontaneous preterm delivery before 37 and 34weeks, low birthweight (≤2500g), small-for-gestational-age, preterm premature rupture of membranes and neonatal mortality. Multivariable log binominal regression analyses were applied. Results: Preterm delivery before 37weeks was more common among women with abnormal cervical cytology compared with reference group: 6% vs 4.5%; adjusted relative risk 1.30 (95% confidence interval 1.21-1.39). High vs low-grade abnormal cervical cytology implied a higher risk: 7% vs 5.8% (P<0.001). Early preterm delivery before 34weeks, preterm premature rupture of membranes and low birthweight, but not small-for-gestational-age and neonatal mortality, were significantly more common in women with abnormal cervical cytology compared with the reference group. Conclusions: Abnormal cervical cytology may imply an increased risk of preterm delivery. Further studies are needed to investigate whether that risk is related to treatment.
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| 26. |
- Jonasson, Kristina, et al.
(författare)
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Squamous cell carcinoma of the mobile tongue in young adults: A Swedish head & neck cancer register (SweHNCR) population-based analysis of prognosis in relation to age and stage
- 2023
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Ingår i: Oral Oncology. - : Elsevier BV. - 1368-8375 .- 1879-0593. ; 144
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Tidskriftsartikel (refereegranskat)abstract
- Increased incidence of squamous cell carcinoma (SCC) of the tongue has been reported in young adults (YA) in several countries since the 1980s and confirmed in later studies. The etiology is unclear, the prognosis has been debated, and conflicting results have been published. Some studies show better survival in young adults than in older patients, some worse, and others no difference. Most studies are based on selected series or include other sites in the oral cavity. The definition of "YA" is arbitrary and varies between studies. It is thus difficult to use in general conclusions.This work uses data from the population-based Swedish Head and Neck Cancer register (SweHNCR), which has > 98% coverage. SweHNCR data includes age, gender, TNM, treatment intention, treatment given, lead times, performance status, and to a lesser degree, smoking habits. The current Swedish population is around 10 million.We analyzed outcomes for 1416 patients diagnosed with SCC of the oral tongue from 2008 to 2017 using 18-39 years to define YA age because it is the range most commonly used.We found no significant difference in relative survival (a proxy for diagnosis-specific survival) between age groups of patients treated with curative intent for SCC of the oral tongue. The stage at time of diagnosis was equally distributed among the age groups. Excess mortality rate correlated mainly with stage, subsite of the tongue, performance status, and lead time to treatment.
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| 27. |
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| 28. |
- Li, Ci, et al.
(författare)
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The Poses for Equine Research Dataset (PFERD)
- 2024
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Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Studies of quadruped animal motion help us to identify diseases, understand behavior and unravel the mechanics behind gaits in animals. The horse is likely the best-studied animal in this aspect, but data capture is challenging and time-consuming. Computer vision techniques improve animal motion extraction, but the development relies on reference datasets, which are scarce, not open-access and often provide data from only a few anatomical landmarks. Addressing this data gap, we introduce PFERD, a video and 3D marker motion dataset from horses using a full-body set-up of densely placed over 100 skin-attached markers and synchronized videos from ten camera angles. Five horses of diverse conformations provide data for various motions from basic poses (eg. walking, trotting) to advanced motions (eg. rearing, kicking). We further express the 3D motions with current techniques and a 3D parameterized model, the hSMAL model, establishing a baseline for 3D horse markerless motion capture. PFERD enables advanced biomechanical studies and provides a resource of ground truth data for the methodological development of markerless motion capture.
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| 29. |
- Löberg, Johanna, 1981, et al.
(författare)
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Electronic Properties of TiO2 Nanoparticles Films and the Effect on Apatite-Forming Ability.
- 2013
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Ingår i: International journal of dentistry. - : Hindawi Limited. - 1687-8728 .- 1687-8736. ; 2013
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Tidskriftsartikel (refereegranskat)abstract
- Nanoparticle-covered electrodes have altered properties as compared to conventional electrodes with same chemical composition. The changes originate from the large surface area and enhanced conduction. To test the mineralization capacity of such materials, TiO2 nanoparticles were deposited on titanium and gold substrates. The electrochemical properties were investigated using cyclic voltammetry and impedance spectroscopy while the mineralization was tested by immersion in simulated body fluid. Two types of nucleation and growth behaviours were observed. For smooth nanoparticle surfaces, the initial nucleation is fast with the formation of few small nuclei of hydroxyapatite. With time, an amorphous 2D film develops with a Ca/P ratio close to 1.5. For the rougher surfaces, the nucleation is delayed but once it starts, thick layers are formed. Also the electronic properties of the oxides were shown to be important. Both density of states (DOS) in the bandgap of TiO2 and the active area were determined. The maximum in DOS was found to correlate with the donor density (N d ) and the active surface area. The results clearly show that a rough surface with high conductivity is beneficial for formation of thick apatite layers, while the nanoparticle covered electrodes show early nucleation but limited apatite formation.
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| 30. |
- Lönngren, Johanna, 1985-, et al.
(författare)
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Dealing with the multidimensionality of sustainability through the use of multiple perspectives : a theoretical framework
- 2016
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Ingår i: European Journal of Engineering Education. - : Informa UK Limited. - 0304-3797 .- 1469-5898. ; 41:3, s. 342-352
-
Tidskriftsartikel (refereegranskat)abstract
- The concept of perspectives is important in discussions about the multidimensionality of sustainability problems and the need to consider many different aspects when dealing with them. This paper aims to facilitate discussions among both educators and researchers about didactical approaches to developing students’ abilities to deal with the multidimensionality of sustainability challenges through the use of multiple perspectives. For this purpose, a theoretical framework was developed that describes perspectives in terms of a set of general characteristics, as well as a number of ways in which students can develop and reflect on perspectives. Development of the framework was supported by a qualitative content analysis of transcripts from interviews with undergraduate engineering students in Sweden.
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| 31. |
- Lönngren, Johanna, 1985-
(författare)
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Engineering students’ ways of relating to wicked sustainability problems
- 2014
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This licentiate thesis constitutes a part of a larger research effort that aims to provide a theoretical framework for understanding and working with engineering students’ ways of relating to wicked sustainability problems (WSPs) on the basis of conceptual, empirical, and practical considerations. Thus, the project aims to contribute to an understanding of how engineering education can support students in developing the capabilities that they need to actively participate in discussions about sustainable development and to constructively deal with WSPs.The concept of perspectives provides a point of departure for the research. Paper I introduces a conceptual framework for conceiving of and communicating about perspectives and perspective processes in the context of engineering education for sustainable development. In Paper II, four qualitatively different ways in which engineering students understand and approach a specific WSP are described based on an empirical study. The results from the study suggest that a partial experience of the complexity of WSPs may lower rather than increase students’ abilities to deal with WSPs, and that educators therefore should pay attention to support the students in progressing beyond this level. A combination of the results from the two papers provides input for discussions about what it may mean to fully appreciate the complexity of WSPs, and a basis for more practice-oriented research in line with the aim of this research.
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| 32. |
- Lönngren, Johanna, 1985-
(författare)
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Wicked Problems in Engineering Education : Preparing Future Engineers to Work for Sustainability
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Most engineering education today does not adequately prepare students to contribute to sustainability. For example, engineering students often do not learn how to address complex and ill-structured sustainability problems that involve different stakeholders, value conflicts,and uncertainty; such problems are also called wicked problems. Efforts to improve engineering education in this regard are hampered by a lack of research on how engineering education can prepare students to address wicked problems.This thesis aims to address this gap in two parts. The research described in Part 1 aimed toexplore what engineering students need to learn to be able to address wicked problems. For this purpose, a pre-study literature review and two empirical studies were conducted. For the empirical studies, engineering students were interviewed and the interviews were analyzedusing qualitative content analysis (Study 1) and a phenomenographic approach (Study 2). The research in Part 2 aimed to link the theoretical results from Part 1 to engineering education practice by focusing on teaching and assessment. The research in Part 2 comprises two empirical studies in which pragmatic action research (Study 3) and design-based research (Study 4) was used.The results of the research include (a) a description of engineering education-specific challenges in addressing wicked problems; (b) 3 descriptions of wicked problems and design principles for wicked problem descriptions; (c) description of four different approaches that engineering students have used in addressing a wicked problem; (d) 22 intended learning outcomes, 3 assessment approaches, an analytic assessment rubric, and a rubric-based intervention for students’ ability to integratively address wicked problems; (e) validity, reliability, and utility evaluations of the assessment rubric; and (f) insights about students’ performance, their approaches to wicked problems, and affordances for learning in differently scaffolded activities during the rubric-based intervention.Conclusions from the research include that an integrative approach to wicked problems is most appropriate, that students are able to use such an approach, but that they may need instructional support to do so. Conclusions further include that strong cognitive scaffoldingwith a highly detailed assessment rubric can support students’ understanding of the nature of wicked problems and students’ performance in written responses to wicked problems, but possibly also limit affordances for deep and transferable learning.
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| 33. |
- Mercke Odeberg, Johanna, et al.
(författare)
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UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females
- 2006
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Ingår i: European Journal of Clinical Pharmacology. - : Springer Science and Business Media LLC. - 0031-6970 .- 1432-1041. ; 62:10, s. 829-837
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The objective of this study was to investigate the prevalence of different polymorphisms and haplotypes associated with individual variations in pharmacokinetics and drug toxicity in the uridine-diphosphate glucuronosyl transferase (UGT) 1A gene in a Swedish cohort (248 healthy volunteers) and in 14 different ethnic groups. We also estimated UGT1A genotype-dependent glucuronidation efficiency using the endogenous substrate bilirubin as an indicator. Methods: Pyrosequencing-based genotyping assays were used to determine the different polymorphisms and haplotypes. Results: Haplotype analysis of the UGT1A1 (*1*28), UGT1A6 (*1*2), and UGT1A7(*1*2*3*4) allelic variants showed that three major haplotypes constituted 84% of the allelic variants in the cohort. We identified 15 haplotypes altogether from all groups, including previously undescribed haplotypes.Testing for the association of genotype and total bilirubin levels (nonfasting) in plasma disclosed that homozygous carriers of the TA allele, irrespective of haplotype combinations, had increased levels of bilirubin compared with noncarriers, but a gender-associated difference was observed. Conclusions: In a Swedish cohort, several genetic variants in the UGT1A gene are common, but prevalence in a population may differ because of ethnicity. A phenotype based on bilirubin levels has limitations in serving as an indicator of pharmacogenetic differences in glucuronidation due to the influence of gender. Because of possible substrate overlap regarding different UGT1A isoforms, determination of haplotypes of potential cis-acting polymorphisms in the UGT1A gene should be considered in pharmacogenetic association studies regarding drugs that undergo glucuronidation.
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| 34. |
- Moldan, Filip, et al.
(författare)
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NKL-1915 National Nitrogen Budgets in Scandinavia: consequences for climate change and for eutrophication – synthesis report
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report presents the results of a project undertaken by Norway, Finland, Sweden, and Denmark related to the National Nitrogen Budget (NNB) with a focus on the NNB pool Forests and semi-natural vegetation (FS). The NNB involves calculations of reactive nitrogen (Nr) inflows and outflows within the FS pool, and the study compares these calculations to reports of carbon sequestration in climate reporting to the United Nations Framework Convention on Climate Change (UNFCCC).Norway and Finland initiated their work on NNB, concentrating on Forests and semi-natural vegetation (FS). The UNECE LRTAP Task Force on Reactive Nitrogen (TFRN) methodology was also used for compiling the FS pool for Denmark, while Sweden had established its FS pool prior to the project.The FS pool comprises three sub-pools: forests, wetlands, and other lands. Inflows of reactive nitrogen (Nr) to the FS pool are primarily from deposition and biological N-fixation, with major outflows being leaching, harvest, and denitrification.In Finland, Sweden, and Denmark, the inflows and outflows are in balance, while in Norway, there is an accumulation of Nr, indicating a surplus of nitrogen. Wetland sub-pools in all four countries and the forest sub-pool in Norway show nitrogen accumulation.All four countries report carbon sequestration in forests to UNFCCC.There is a link between nitrogen and carbon cycles, since the organic matter forming the carbon stock in forests and wetlands relies on nitrogen. The origin of nitrogen contributing to the estimated C-stock increase needs further investigation.There is a discrepancy between the calculated nitrogen changes in the FS pool and the nitrogen needed to support reported carbon stock changes. Possible explanations for the discrepancies are re-location of nitrogen within pools, changes in the C/N ratio, expansion of forested areas, and uncertainties in N-fixation rates and denitrification.There is a need for better integration of carbon and nitrogen flux and stock change estimates in natural ecosystems. Understanding the interactions between carbon and nitrogen is deemed crucial for predicting future developments in carbon sequestration and impacts of nitrogen deposition, especially for the Nordic countries with their significant forests playing roles as carbon and nitrogen sinks.
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| 35. |
- Pawitan, Yudi, et al.
(författare)
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Gene expression profiling spares early breast cancer patients from adjuvant therapy : derived and validated in two population-based cohorts
- 2005
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Ingår i: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 7:6, s. R953-64
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast cancer expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant therapy but without demonstrated value for therapy prediction. METHODS: We obtained the gene expression profiles of 159 population-derived breast cancer patients, and used hierarchical clustering to identify the signature associated with prognosis and impact of adjuvant therapies, defined as distant metastasis or death within 5 years. Independent datasets of 76 treated population-derived Swedish patients, 135 untreated population-derived Swedish patients and 78 Dutch patients were used for validation. The inclusion and exclusion criteria for the studies of population-derived Swedish patients were defined. RESULTS: Among the 159 patients, a subset of 64 genes was found to give an optimal separation of patients with good and poor outcomes. Hierarchical clustering revealed three subgroups: patients who did well with therapy, patients who did well without therapy, and patients that failed to benefit from given therapy. The expression profile gave significantly better prognostication (odds ratio, 4.19; P = 0.007) (breast cancer end-points odds ratio, 10.64) compared with the Elston-Ellis histological grading (odds ratio of grade 2 vs 1 and grade 3 vs 1, 2.81 and 3.32 respectively; P = 0.24 and 0.16), tumor stage (odds ratio of stage 2 vs 1 and stage 3 vs 1, 1.11 and 1.28; P = 0.83 and 0.68) and age (odds ratio, 0.11; P = 0.55). The risk groups were consistent and validated in the independent Swedish and Dutch data sets used with 211 and 78 patients, respectively. CONCLUSION: We have identified discriminatory gene expression signatures working both on untreated and systematically treated primary breast cancer patients with the potential to spare them from adjuvant therapy.
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| 36. |
- Petersson, Annika, et al.
(författare)
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Differences in SARS-CoV-2 antibodies depending on age, blood group, and sex in a Swedish blood donor cohort
- 2024
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - : Taylor & Francis. - 0036-5513 .- 1502-7686.
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to describe differences in prevalence and the long-term presence of nucleocapsid antibodies (N-antibodies) elicited by SARS-CoV-2 infection in a Swedish blood donor population not subjected to lockdown. We tested 20,651 blood donor samples for nucleocapsid antibodies from the beginning of March 2020 and 27 months onwards using the Roche Elecsys Anti-SARS-CoV-2 assay. The proportion of positive SARS-CoV-2 antibody samples was determined each week. After the exclusions of one-time donors and subjects with incomplete data, 19,726 samples from 4003 donors remained. Differences in antibody prevalences stratified for age, sex, and blood groups (ABO and RhD) were determined, as well as antibody loss and recovery. Lower antibody prevalence was seen for older donors, blood group AB, and RhD-negative subjects. A significant decrease in antibody titer between the first and the second antibody-positive donation was seen for the whole study group, females, older subjects, blood group O, AB, and RhD-positive subjects. The titer waned below the detection limit in 60 (3.0%) of 1983 N-antibody-positive donors, and for 18 of these donors, a second episode with antibodies was detected. We showed that N-antibodies persist for months or years and that surprisingly few antibody-positive donors lost their antibodies. We also conclude that antibody prevalence in a Swedish population never subject to lockdown did not apparently differ from populations that were subject to stricter regulations.
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| 37. |
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| 38. |
- Shen, Xianli, et al.
(författare)
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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
- 2016
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Ingår i: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 17:11, s. 1282-1290
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Tidskriftsartikel (refereegranskat)abstract
- Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ability. The underlying molecular mechanism used by glioma cells to transform microglia into a tumor-supporting phenotype has remained elusive. We found that glioma-induced microglia conversion was coupled to a reduction in the basal activity of microglial caspase-3 and increased S-nitrosylation of mitochondria-associated caspase-3 through inhibition of thioredoxin-2 activity, and that inhibition of caspase-3 regulated microglial tumor-supporting function. Furthermore, we identified the activity of nitric oxide synthase 2 (NOS2, also known as iNOS) originating from the glioma cells as a driving stimulus in the control of microglial caspase-3 activity. Repression of glioma NOS2 expression in vivo led to a reduction in both microglia recruitment and tumor expansion, whereas depletion of microglial caspase-3 gene promoted tumor growth. Our results provide evidence that inhibition of the denitrosylation of S-nitrosylated procaspase-3 mediated by the redox protein Trx2 is a part of the microglial pro-tumoral activation pathway initiated by glioma cancer cells.
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| 39. |
- Smeds, Johanna, et al.
(författare)
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Ductal carcinoma in situ of the breast with different histopathological grades and corresponding new breast tumour events : analysis of loss of heterozygosity
- 2005
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 44:1, s. 41-9
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Tidskriftsartikel (refereegranskat)abstract
- To compare chromosomal alterations in ductal carcinoma in situ (DCIS) of different histopathological grades and to study aberrations between primary DCIS and corresponding ipsi- or contralateral new in situ or invasive tumours, a study was undertaken of the pattern of loss of heterozygosity (LOH) at chromosomal regions in which LOH has previously been described in invasive breast cancer. LOH was analysed using 19 microsatellite markers located on chromosomes 3p, 6q, 8p, 8q, 9p, 11p, 11q, 16q, 17p, and 17q in 30 women with a primary DCIS. Eleven women with DCIS of grade 1 and 19 with grade 3 according to the EORTC classification system were included. In six patients LOH was also analysed in a subsequent new breast cancer. Fractional allelic loss (FAL, the ratio of chromosomal arms where allelic loss was detected divided by the total number of chromosomal arms with informative markers) was statistically significantly higher in grade 1 DCIS compared with grade 3 (p=0.02) for the 19 loci, indicating that the amount of allelic loss does not correlate with increasing aggressiveness of the studied tumours. Also observed was a complete heterogeneity of LOH in the primary DCIS and their corresponding new events, suggesting that these events probably developed from genetically divergent clones.
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| 40. |
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| 41. |
- Zetterberg, Johanna, et al.
(författare)
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Nurses’ experiences of encountering patients with mental illness in prehospital emergency care – a qualitative interview study
- 2022
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Ingår i: BMC Nursing. - : BioMed Central. - 1472-6955. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Nurses working in prehospital emergency care (PEC) encounter patients with all types of health conditions. Increasingly, they are encountering patients suffering from mental illness and this trend reflects the worldwide increase in mental illness. There is very little current knowledge of encounters between nurses and patients with mental illness in ‘PEC’, especially from the nurses’ perspectives.Aim The aim of the study is to investigate nurses’ experiences of encountering patients with mental illness in ‘PEC’.Methods The participants were recruited in a region in southeast Sweden (that covers approximately 5600 km2 and has 300,000 inhabitants). In total, 17 nurses consented to participate. The participants were asked to narrate their individual experience of encountering patients with mental illness. The interviews were transcribed verbatim, then analysed with qualitative content analysis.Results The result is presented in terms of three themes and eight sub-themes. The main themes are ‘Lacking trust in the patient and one’s own abilities’, ‘Being under internal and external influences’ and ‘Moving towards a genuine nurse-patient relationship’.Conclusion The results show that nurses strive to lay the foundation for a trusting relationship. Simultaneously nurses encountering is characterized by a mistrust and it is influenced by pre-understanding and emotions when they take care for patients. The findings could be used to develop nurses’ readiness and capability to encounter patients with mental illness and to respond appropriately to the patients somatic and mental care needs.
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