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Sökning: WFRF:(Holmen Anders)

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1.
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2.
  • Gavrilovic, Ljubisa, et al. (författare)
  • Influence of potassium species on Co based Fischer-Tropsch-catalyst.
  • 2016
  • Konferensbidrag (refereegranskat)abstract
    • 1. IntroductionThe purpose of this work is better understanding of the alkali influence on Co-based F-T catalyst. Since potassium is one of the elements that can be present in syngas from biomass[1], one of the questions is how potassium species affect the Co catalyst. From previous work it has been shown that alkali species act as poisons, thus deactivating catalysts[2]. Most previous work in this group[3][4] and by others[5] has concerned Co catalysts that were exposed to potassium species by incipient wetness impregnation, which is essentially different from the real behaviour during the gasification process where the species will mainly be in the vapor phase. In the present work we study potassium influence on a Co-based catalyst, using aerosol technology as a new method for potassium deposition on the Co surface. 2. Experimental4 different potassium salts were deposited using aerosol deposition on 20%Co/0.5%Re/γAl2O3. The amount of potassium salts deposited were determined using ICP analysis. Potassium salts were chosen from studies of the gases from biomass gasification[6]. These are K2SO4, KCl, KNO3 and K2CO3. KNO3 will be reduced to KOH during biomass gasification, but since in these experiments temperature was not so high and there was no H2/CO, most likely KNO3 will be deposited as such on the Co surface.BET N2 adsorption, H2 chemisorption, temperature programmed reduction (TPR) were used to characterize all the poisoned catalysts.Fischer Tropsch activity and selectivity measurements were performed at the in house build set-up, at 210°C, 20 bar and at H2:CO ratio of 2.1. The GHSV was consistently varied to maintain comparable CO conversion levels between 20-50%. A detailed description of the setup and procedures can be found elsewhere[3]. 3. ResultsThe potassium species were deposited using aerosol technology in the apparatus shown in Fig. 1. Potassium salts are dissolved in deionized water and the solution is placed inside the atomizer, which produces aerosol particles. Nitrogen is used as a carrier gas which forces aerosol particles in the reactor direction. Before entering the reactor, the gas mixture carrying the aerosol is passing the impaction vessel to remove large particles. The catalyst bed is placed in the middle of the reactor, which can be heated up to 800°C. The generated aerosol particles were physically characterized according to their electrical mobility using a scanning mobility particle sizer (SMPS) consisting of a differential mobility analyser (DMA) and a condensation particle counter (CPC)[7]. The three target concentrations of potassium salts,  200 ppm, 800 ppm and 4000 ppm,  were monitored by the above-mentioned instruments.Results from characterization by elemental analysis, H2 chemisorption, BET surface area, TPR together with the results from the Fischer Tropsch synthesis i.e. CO conversion, selectivity, and activity will be compared with the same catalyst without any poison and also with previous results obtained from solution impregnation of the same poisons[8][3][9].4. DiscussionThe purpose of the work is to study how this procedure of poisoning Co catalyst with aerosol particles will affect catalyst performances during Fischer Tropsch reaction. Previous similar work on Ni catalyst in the SCR reaction using aerosol technology as a method of deposition, has proven loss in metallic surface area, decreasing of metal dispersion and severe reduction in the catalytic activity [7]. The idea is to develop a technique to transfer potassium species, and potentially other relevant impurities, in vapor phase to the catalyst surface. This new approach can to a great extent simulate behaviour during the real industrial process. The aerosol could better represent in situ poisoning and therefore give a more realistic picture of the effect of potassium. This knowledge will be useful for designing new BTL processes. 5. ConclusionAerosol technology was used as a new method for depositing potassium salts on the Co surface. Poisoned catalysts were tested in Fischer Tropsch synthesis reactor together with elemental analysis. Results are compared to the reference catalyst and with previous work which use IWI as poisoning method.  6. References[1]       A. Norheim, D. Lindberg, J. E. Hustad, and R. Backman, Energy and Fuels, (2009)[2]       E. S. Wangen, A. Osatiashtiani, and E. A. Blekkan, Top. Catal., (2011)[3]       C. M. Balonek, A. H. Lillebø, S. Rane, E. Rytter, L. D. Schmidt, and A. Holmen, Catal. Letters, (2010)[4]       E. A. Blekkan, A. Holmen, S. Vada, Acta Chem. Scand., (1993)[5]       J. Gaube and H. F. Klein, Appl. Catal. A Gen., (126–132, 2008)[6]       H. M. Westberg, M. Byström, and B. Leckner, Energy and Fuels, (18–28, 2003)[7]       S. Albertazzi, F. Basile, J. Brandin, J. Einvall, G. Fornasari, C. Hulteberg, M. Sanati, F. Trifirò, and A. Vaccari, Biomass and Bioenergy, (2008)[8]       A. H. Lillebø, E. Patanou, J. Yang, E. A. Blekkan, and A. Holmen, in Catalysis Today, (2013)[9]       E. Patanou, A. H. Lillebø, J. Yang, D. Chen, A. Holmen, and E. A. Blekkan, Ind. Eng. Chem. Res., (2014)[10]     J. Einvall, S. Albertazzi, C. Hulteberg, A. Malik, F. Basile, A. C. Larsson, J. Brandin, and M. Sanati, Energy and Fuels, (2007)
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3.
  • Holmén, Anders, 1967, et al. (författare)
  • Assignment of electronic transition moment directions of adenine from linear dichroism measurements
  • 1997
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 119:50, s. 12240-12250
  • Tidskriftsartikel (refereegranskat)abstract
    • The electronic spectra of a series of adenine derivatives have been investigated with respect to the number of electronic transitions, their intensities, and transition moments. The experimental work includes linear dichroism (LD) measurements on samples partially oriented in stretched polymer poly(vinyl alcohol) films, fluorescence anisotropy (FA), and: magnetic circular dichroism (MCD). The UV spectra of both 7-methyladenine (7MA) and 9-methyladenine (9MA) are resolved into contributions from five pi --> pi* transitions (I-V). Their polarizations relative to the C-4-C-5 axis are for 7MA +45 degrees (I, 36 600 cm(-1)), -16 degrees (II, 39 500 cm(-1)), -28 degrees (III, 42 600 cm(-1)), +76 degrees (IV 45 800 cm(-1)) and similar to-29 degrees (V, similar to 47 700 cm(-1)); and for 9MA +66 degrees (I, 36 700 cm(-1)), +19 degrees (II, 38 820 cm(-1)), -15 degrees (III, 43 400 cm(-1)), -21 degrees (IV, 46 800 cm(-1)), and similar to-64 degrees (V, similar to 48 320 cm(-1)). The experimental results are correlated with results from semiempirical INDO/S and ab initio CIS/6-31G(d) and CASPT2 molecular orbital calculations. The transition moments are found to be conserved when the adenine amino group has been substituted with either one or two methyl groups. In addition, LD and MCD spectra for 6-(dimethylamino)-9-ethylpurine, which is soluble in nonpolar solvents, have been measured in stretched polyethylene film and cyclohexane, respectively. The results indicate that the electronic transition moments of the 9-substituted adenine chromophore are essentially the same in a polar and a nonpolar solvent. On the basis of the. results,for 7MA and 9MA, the reduced LD and absorption spectra of adenine are analyzed in terms of contributions from the 7-H and 9-H tautomers of adenine. By comparison with theoretical and experimental results for purine and 2-aminopurine regarding the position of the lowest n --> pi* transition, we are able to confidently position the lowest n --> pi* transition in 9MA very close to the lowest pi --> pi* transition. The proximity of the first (1)n pi* and (1) pi pi* states in adenine might be related to the efficient nonradiative deactivation of the lowest excited (1) pi pi* state.
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4.
  • Holmén, Anders, 1967, et al. (författare)
  • Ir Transition Moments of 1,3-Dimethyluracil - Linear Dichroism Measurements and Ab-Initio Calculations
  • 1994
  • Ingår i: Journal of Physical Chemistry. - 0022-3654. ; 98:19, s. 4998-5009
  • Tidskriftsartikel (refereegranskat)abstract
    • The vibrational transition moment directions of 1,3-dimethyluracil (DMU), 1,3-dimethyluracil-5-d (DMU-5-d), and 1,3-dimethyluracil-6-d (DMU-6-d) have been determined from measurements of polarized IR spectra on samples partially aligned in stretched poly(vinyl alcohol) and by ab initio calculations at the HF/6-31G* level of approximation. The agreement between experiments and theory is good. IR spectra of DMU, DMU-5-d, and DMU-6-d in KBr and in D2O form, together with the calculated spectra and the IR polarizations, the basis for some reassignments. Special attention is paid to the double-bond region, where the high-frequency carbonyl stretching mode is assigned to an in-phase vibration of the C4O and the C2O. This vibration is polarized in a direction almost bisecting the angle between the two carbonyl bonds, in agreement with an in-phase assignment. The low-frequency mode is the out-of-phase vibration of the two carbonyl groups, and it is consequently polarized perpendicular to the high-frequency mode. In order to determine the orientation axis of DMU in the polymer matrix, the UV linear dichroism (LD) spectrum was measured and the polarizations of the electronic transitions were estimated from a semiempirical self-consistent reaction field (SCRF) calculation including solvent effects. The combined information from IR LD and UV LD shows that the molecular orientation axis in the stretched film experiment is parallel to the first pi --> pi* transition in DMU.
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5.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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6.
  • Rydén, Magnus, 1975, et al. (författare)
  • Novel oxygen-carrier materials for chemical-looping combustion and chemical-looping reforming; LaxSr1─xFeyCo1─yO3─δ perovskites and mixed-metal oxides of NiO, Fe2O3 and Mn3O4
  • 2008
  • Ingår i: International Journal of Greenhouse Gas Control. - 1750-5836. ; 2:1, s. 21-36
  • Tidskriftsartikel (refereegranskat)abstract
    • Solid oxygen-carrier materials for chemical-looping applications have been examined by reduction with CH4 and oxidation with air in a fixed-bed quartz reactor at 900ºC. Four perovskite materials, three metal-oxide materials and four metal-oxide mixtures have been studied. It was found that LaxSr1─xFeO3─δ perovskites provided very high selectivity towards CO/H2 and should be well suited for chemical-looping reforming. Substituting La for Sr was found to increase the oxygen capacity of these materials, but reduced the selectivity towards CO/H2 and the reactivity with CH4. La0.5Sr0.5Fe0.5Co0.5O3─δ was found to be feasible for chemical-looping combustion applications. NiO/MgAl2O4 propagated formation of solid carbon, likely due to the catalytic properties of metallic Ni. Fe2O3/MgAl2O4 had properties that made it interesting both for chemical-looping combustion and chemical-looping reforming. Adding 1% NiO particles to a bed of Fe2O3-particles increased both reactivity with CH4 and selectivity towards CO/H2 for reforming applications. Mn3O4/Mg­ZrO2 was found to be suitable for chemical-looping combustion applications, but it could not be verified that adding NiO produced any positive effects.
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7.
  • Shungin, Dmitry, et al. (författare)
  • New genetic loci link adipose and insulin biology to body fat distribution.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
  • Tidskriftsartikel (refereegranskat)abstract
    • Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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8.
  • Almquist-Tangen, Gerd, et al. (författare)
  • Influence of neighbourhood purchasing power on breastfeeding at four months of age : a Swedish population-based cohort study
  • 2013
  • Ingår i: BMC Public Health. - London : BioMed Central. - 1471-2458. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Parental socioeconomic status (SES) is an important determinant in child health, influencing beneficial factors such as breastfeeding. A better understanding of the influence of neighbourhood-level SES measures, relating to spatial determinants, might lead to targeted actions to promote breastfeeding during infancy.METHODS: A cross-sectional study analysis the association between breastfeeding at four months of age and neighbourhood purchasing power, taking account of individual-level variables including maternal age, smoking and parental level of education. Data were obtained from a prospective population- based cohort study recruited from birth in 2007-2008 in the Halland region, southwestern Sweden. Questionnaire data on the individual-level variables and the outcome variable of breastfeeding at four months (yes/no) were used (n=2,407). Each mother was geo-coded with respect to her residential parish (there are 61 parishes in the region) and then stratified by parish-level household purchasing power. It emerged that four neighbourhood characteristics were reasonable to use, viz. <10%, 10-19%, 20-29% and ≥ 30% of the resident families with low purchasing power.RESULTS: The proportion of mothers not breastfeeding at four months of age showed a highly significant trend across the neighbourhood strata (p=0.00004): from 16.3% (< 10% with low purchasing power) to 29.4% (≥ 30% with low purchasing power), yielding an OR of 2.24 (95% confidence interval: 1.45-3.16). After adjusting for the individual-level variables, the corresponding OR=1.63 (1.07-2.56) was significant and the trend across the strata was still evident (p=0.05). A multi-level analysis estimated that, in the neighbourhoods with ≥ 30% of the families with low purchasing power, 20% more mothers than expected, taking account of the individual-level factors, reported no breastfeeding at four months of age (≥ 95% posterior probability of an elevated observed-to-expected ratio).CONCLUSION: The neighbourhood purchasing power provided a spatial determinant of low numbers of mothers breastfeeding at four months of age, which could be relevant to consider for targeted actions. The elevated observed-to-expected ratio in the neighbourhoods with the lowest purchasing power points toward a possible contextual influence. © 2013 Almquist-Tangen et al.; licensee BioMed Central Ltd.
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9.
  • Andersson, Robert (författare)
  • Catalytic conversion of syngas to higher alcohols over MoS2-based catalysts
  • 2015
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The present thesis concerns catalytic conversion of syngas (H2+ CO) into a blend of methanol and higher alcohols, an attractive way of producing fuels and chemicals. This route has the potential to reduce the oil dependence in the transport sector and, with the use of biomass for the syngas generation, produce CO2-neutral fuels.Alkali promoted MoS2-based catalysts show a high selectivity to higher alcohols, while at the same time being coke resistant, sulfur tolerant and displaying high water-gas shift activity. This makes this type of catalyst especially suitable for being used with syngas derived from biomass or coal which typically has a low H2/CO-ratio.This thesis discusses various important aspects of higher alcohol synthesis using MoS2-based catalysts and is a summary of four scientific papers. The first part of the thesis gives an introduction to how syngas can be produced and converted into different fuels and chemicals. It is followed by an overview of higher alcohol synthesis and a description of MoS2-based catalysts. The topic alcohol for use in internal combustion engines ends the first part of the thesis.In the second part, the experimental part, the preparation of the MoS2-based catalysts and the characterization of them are handled. After describing the high-pressure alcohol reactor setup, the development of an on-line gas chromatographic system for higher alcohol synthesis with MoS2 catalysts is covered (Paper I). This method makes activity and selectivity studies of higher alcohol synthesis catalysts more accurate and detailed but also faster and easier. Virtually all products are very well separated and the established carbon material balance over the reactor closed well under all tested conditions. The method of trace level sulfur analysis is additionally described.Then the effect of operating conditions, space velocity and temperature on product distribution is highlighted (Paper II). It is shown that product selectivity is closely correlated with the CO conversion level and why it is difficult to combine both a high single pass conversion and high alcohol selectivity over this catalyst type. Correlations between formed products and formation pathways are additionally described and discussed. The CO2 pressure in the reactor increases as the CO conversion increases, however, CO2 influence on formation rates and product distribution is to a great extent unclear. By using a CO2-containing syngas feed the effect of CO2 was studied (Paper III).An often emphasized asset of MoS2-based catalysts is their sulfur tolerance. However, the use of sulfur-containing feed and/or catalyst potentially can lead to incorporation of unwanted organic sulfur compounds in the product. The last topic in this thesis covers the sulfur compounds produced and how their quantity is changed when the feed syngas contains H2S (Paper IV). The effect on catalyst activity and selectivity in the presence of H2S in the feed is also covered.
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10.
  • Bakhtiary-Davijany, Hamidreza, et al. (författare)
  • Analysis of External and Internal Mass Transfer at Low Reynolds Numbers in a Multiple-Slit Packed Bed Microstructured Reactor for Synthesis of Methanol from Syngas
  • 2012
  • Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 0888-5885 .- 1520-5045. ; 51:42, s. 13574-13579
  • Tidskriftsartikel (refereegranskat)abstract
    • The possibility of mass transfer limitations in an integrated micro packed bed reactor-heat exchanger (IMPBRHE) for methanol synthesis was experimentally investigated. Experiments were performed with three different particle size distributions (50-200 mu m) of a Cu-based catalyst at 80 bar and 215-270 degrees C. Negligible effects of pore diffusion limitations on the performance of the reactor under methanol synthesis conditions for catalyst particle diameters up to 125 mu m were found. Due to a very low Reynolds numbers (similar to 1) and dominance of molecular diffusion, variation of the total pressure was applied as a suitable technique to alter the diffusivities of reactants in the gas mixture by dilution, while keeping the reactant flow and partial pressure constant. No significant change in the CO conversion was observed in the temperature range 235-255 degrees C, pressure range 50-90 bar, and for reactant contact times of 105-308 ms.g/mL. The same procedure was applied to a laboratory. fixed bed reactor with similar results. Possible heat transfer effects associated with the dilution were shown to be negligible. We therefore conclude that both reactor systems operate in the absence of external mass transfer limitations.
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11.
  • Calcagnile, Olga, et al. (författare)
  • S100B levels are affected by older age but not by alcohol intoxication following mild traumatic brain injury
  • 2013
  • Ingår i: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. - : Springer Science and Business Media LLC. - 1757-7241. ; 21
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Biomarkers of brain damage and head injury are potentially useful tools in the management of afflicted patients. Particularly S100B has received much attention and has been adapted into clinical guidelines. Alcohol intoxication and higher age (65 years and over) have been used as risk factors for serious complications following head injury. The effect of these factors on S100B levels has not been fully established in a relevant patient cohort. Methods: We prospectively included 621 adult patients with mild traumatic brain injury (TBI) and S100B sampling. Mild TBI was defined as Glasgow Come Scale 14-15 with loss of consciousness and/or amnesia, but without high-risk factors for intracranial complications. These patients would normally require CT scanning according to local and most international guidelines. S100B was sampled within 3 hours following trauma. Results: 280 patients (45%) were intoxicated by alcohol. Alcohol intoxication had no effect on S100B levels (p = 0.65) and the performance of S100B remained unchanged in these patients. 115 patients (22%) were 65 years or older with elevated S100B levels being more common in this group compared to patients under 65 (p = 0.029). Although the sensitivity of S100B was unchanged in older patients, the specificity was poorer. Conclusion: S100B can be used reliably in mild TBI patients with alcohol intoxication. The clinically utility of S100B in older patients may be limited by very poor specificity leading to only a small decrease in CT scanning.
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12.
  • Carlander, Anders, 1979, et al. (författare)
  • Choices of savings options related to trust in banks’ competence, benevolence and stability
  • 2013
  • Ingår i: Journal of Financial Services Marketing. - : Springer Science and Business Media LLC. - 1363-0539 .- 1479-1846. ; 18:2, s. 121-136
  • Tidskriftsartikel (refereegranskat)abstract
    • The study investigates whether beliefs in professional investor skill in conjunction with trust in banks and other fund managers explain choices of options for long-term savings. From questionnaire data obtained for a population-based sample (n=178) and a sample of undergraduates (n=186), two index measures were constructed, one of beliefs in the skill of professional investors and another of trust in fund managers. The trust index was aggregated for the three interrelated components: competence, benevolence and stability. Regression analyses of the likelihood of savings in an actively managed fund showed an expected effect of investor-skill beliefs that was mediated by trust in the fund manager. In addition, self-reported knowledge played a larger role than trust for choices of passively managed index funds and in particular for own investment in stocks.
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13.
  • Carlander, Anders, 1979, et al. (författare)
  • The role of perceived quality of personal service in influencing trust and satisfaction with banks
  • 2018
  • Ingår i: Financial Services Review. - 1057-0810. ; 27, s. 83-98
  • Tidskriftsartikel (refereegranskat)abstract
    • Trust is of paramount importance to banks. Previous research has shown that trust increases with repeated personal contacts. We investigate if this applies to the customer-employee relationship in banks. Data from an on-line survey of 293 customers of Swedish retail banks are used to construct indicator measures. By means of structural equation modeling we find that trust in the bank is influenced by perceived quality of personal service through employees’ perceived competence, perceived benevolence, and perceived transparency, and that satisfaction with the bank is influenced by perceived quality of personal service through perceived competence, perceived benevolence, perceived transparency, and trust.
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14.
  • Colmenarejo, G., et al. (författare)
  • Electronic Spectra and Transition Moments of 6-(2’-Pyridiniumyl)phenanthridinium Photoactive DNA Intercalators
  • 1997
  • Ingår i: Journal of Physical Chemistry B Materials. - : American Chemical Society (ACS). - 1089-5647 .- 1520-6106 .- 1520-5207. ; 101:26, s. 5196-5204
  • Tidskriftsartikel (refereegranskat)abstract
    • The electronic transitions giving rise to the UV-visible absorption spectra of two pyridinium-phenanthridinium viologens, 6,7-dihydropyridol[2',1':3,4]pyrazinol[1,2-f]phenanthridinediium dication (1) and 7,8-dihydro-6H-pyrido[2',1':3,4]diazepino[1,2-f]phenanthridinediium dication (2), have been investigated with respect to energies, intensities, and transition moment directions. A combination of methods has been applied: UV-visible absorption, circular dichroism, magnetic circular dichroism, fluorescence anisotropy, Linear dichroism In stretched poly(vinyl alcohol) films, and semiempirical molecular orbital calculations. For both drugs, the lowest energy absorption band, occurring around 400 nm, results from two separate transitions. The corresponding electric transition dipole moments lie in the phenanthridine plane and are polarized, respectively, in the direction of the pyridine moiety (the lower energy transition) and parallel to the phenanthridine long axis (the higher energy transition). Up to four additional different pi --> pi* transitions account for a second band that peaks at 250 nm; they show different polarizations within the phenanthridine plane. The lowest energy transition of the whole spectrum of both drugs corresponds to the promotion of an electron from the HOMO to the LUMO, which are molecular orbitals mainly localized in the phenanthridine and pyridine rings, respectively, thereby implying a charge transfer, upon excitation, from the phenanthridine toward the pyridine ring. The experimental and theoretical results are discussed in relation to the spectroscopic, redox, and photochemical properties of these drugs.
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15.
  • Ellingsen, Jan Eirik, et al. (författare)
  • Improved Retention and Bone-to-Implant Contact with Fluoride-Modified Titanium Implants
  • 2004
  • Ingår i: International Journal of Oral & Maxillofacial Implants. - Chicago, Ill.] : Quintessence Pub. Co.. - 0882-2786 .- 1942-4434. ; 19:5, s. 659-666
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: The purpose of the present study was to investigate whether a fluoride modification of the titanium surface would have an effect on bone response after implantation. Materials and Methods: Titanium-oxide–blasted titanium implants with and without fluoride modification were investigated in a rabbit tibia model. Quantitative analysis of surface roughness, biomechanical interlocking, and in vivo tissue reactions in rabbit bone at 1 and 3 months after placement were compared. Results: The fluoride-modified test implants had a slightly smoother surface (Sa: 0.91 ± 0.14 µm) than the unmodified control implants (Sa: 1.12 ± 0.24 µm). Significantly higher removal torque values (85 ± 16 Ncm vs 54 ± 12 Ncm) and shear strength between bone and implants (23 ± 9 N/mm2 vs 15 ± 5 N/mm2) were measured for the fluoride-modified implants after 3 months. The histomorphometric evaluations demonstrated higher bone-to-implant contact for test implants at 1 month (35% ± 14% vs 26% ± 8%) and 3 months (39% ± 11% vs 31% ± 6%) after placement. Discussion: Implant surface modification with fluoride may result in morphologic and physiochemical phenomena that are of significance for the bone response. Another possible explanation for the findings in the present study is that a surface modification changes the surface chemical structures to be more suitable for bone bonding. Conclusion: Based on the biomechanical and histomorphometric data, the fluoride-modified titanium implants demonstrated a firmer bone anchorage than the unmodified titanium implants. These implants achieved greater bone integration than unmodified titanium implants after a shorter healing time. (More than 50 references.)
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16.
  • Ellingsen, Jan Eirik, et al. (författare)
  • Improved retention and bone-tolmplant contact with fluoride-modified titanium implants.
  • 2004
  • Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786. ; 19:5, s. 659-66
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The purpose of the present study was to investigate whether a fluoride modification of the titanium surface would have an effect on bone response after implantation. MATERIALS AND METHODS: Titanium-oxide-blasted titanium implants with and without fluoride modification were investigated in a rabbit tibia model. Quantitative analysis of surface roughness, biomechanical interlocking, and in vivo tissue reactions in rabbit bone at 1 and 3 months after placement were compared. RESULTS: The fluoride-modified test implants had a slightly smoother surface (Sa: 0.91 +/- 0.14 microm) than the unmodified control implants (Sa: 1.12 +/- 0.24 microm). Significantly higher removal torque values (85 +/- 16 Ncm vs 54 +/- 12 Ncm) and shear strength between bone and implants (23 +/- 9 N/mm2 vs 15 +/- 5 N/mm2) were measured for the fluoride-modified implants after 3 months. The histomorphometric evaluations demonstrated higher bone-to-implant contact for test implants at 1 month (35% +/- 14% vs 26% +/- 8%) and 3 months (39% +/- 11% vs 31% +/- 6%) after placement. DISCUSSION: Implant surface modification with fluoride may result in morphologic and physiochemical phenomena that are of significance for the bone response. Another possible explanation for the findings in the present study is that a surface modification changes the surface chemical structures to be more suitable for bone bonding. CONCLUSION: Based on the biomechanical and histomorphometric data, the fluoride-modified titanium implants demonstrated a firmer bone anchorage than the unmodified titanium implants. These implants achieved greater bone integration than unmodified titanium implants after a shorter healing time.
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17.
  • Engdahl, Johan, 1968, et al. (författare)
  • Geographic and socio-demographic differences in uptake of population-based screening for atrial fibrillation: The STROKESTOP I study
  • 2016
  • Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 222, s. 430-435
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The rationale behind screening for atrial fibrillation (AF) is to prevent ischemic stroke. Socio-demographic differences are expected to affect screening uptake. Geographic differences may provide further insights leading to targeted interventions for improved uptake. The objective of this study was to evaluate geographic and socio-demographic differences in uptake of AF screening in the population-based study STROKESTOP I. METHODS: STROKESTOP was carried out in two Swedish counties with a total population of 2.3 million inhabitants. Half of the residents aged 75-76years were randomized to the screening arm: invitation to clinical examination followed by ambulant ECG recording. Information on each invited person's residential parish (n=157) was used. On parish-level, aggregated data for the participants and non-participants, respectively, were obtained with respect to socioeconomic variables: educational level, disposable income, immigrant and marital status. Geo-maps displaying participation ratios were estimated by hierarchical Bayes methods. RESULTS: The overall participation rate was similar in men and women but lower in Stockholm, 47.6% (5665/11,903) than in Halland, 61.2% (1495/2443). Participation was clearly associated with the socioeconomic variables. Participation not taking into account socioeconomy varied more markedly across the parishes in the Stockholm county (range: 0.65-1.26) than in the Halland county (0.94-1.27). After adjustment for socioeconomic variables, a geographic variation remained in Stockholm, but not in Halland. CONCLUSION: Participation in AF screening varied according to socioeconomic conditions. Geographic variation in participation was marked in the Stockholm county, with only one screening clinic. Geo-mapping of participation yielded useful information needed to intervene for improved screening uptake.
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18.
  • Engdahl, Johan, et al. (författare)
  • Uptake of atrial fibrillation screening aiming at stroke prevention: geo-mapping of target population and non-participation
  • 2013
  • Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 35, s. 163-164
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: In a screening study for silent atrial fibrillation (AF), which is a frequent source of cardiac emboli with ischemic stroke, the proportion of non-participants was considerable and their clinical profile differed from the participants' profile. We intended to geo-map the target population and non-participation in an attempt to understand factors related to screening uptake and, thereby, obtain useful information needed to intervene for improved uptake. Method: In the municipality of Halmstad, Sweden, all residents born in 1934-1935 were invited to the screening study during April 2010 to February 2012. The total study group included 848 participants and 367 non-participants from 12 parishes. Geo-maps displaying participation, along with target-population-based geo-maps displaying proportion of immigrants and ischemic stroke incidence, were used. Results: Smoothed non-participation ratios (SmNPR) varied from 0.81 to 1.24 across different parishes (SmNRP = 1 corresponds to the expected participation based on the total study group). Among high risk individuals, the geographical variation was more pronounced (SmNPR range 0.75-1.51). Two parishes with higher share of immigrants and elevated population-based ischemic stroke incidence showed markedly lower participation, particularly among high-risk individuals. Conclusion: AF screening uptake varied evidently between parishes, particularly among high-risk individuals. Geo-mapping of target population and non-participation yielded useful information needed to intervene for improved screening uptake.
  •  
19.
  • Gaulton, Kyle J, et al. (författare)
  • Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
  • 2015
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
  • Tidskriftsartikel (refereegranskat)abstract
    • We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
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20.
  • Gavrilovic, Ljubisa, et al. (författare)
  • Deactivation of Co-based Fischer-Tropsch catalyst by aerosol deposition of potassium salts
  • 2018
  • Ingår i: Industrial & Engineering Chemistry Research. - Washington, USA : American Chemical Society (ACS). - 0888-5885 .- 1520-5045. ; 57:6, s. 1935-1942
  • Tidskriftsartikel (refereegranskat)abstract
    • A 20%Co/0.5%Re/γAl2O3 Fischer-Tropsch catalyst was poisoned by four potassium salts (KNO3, K2SO4, KCl, K2CO3) using the aerosol deposition technique, depositing up to 3500 ppm K as solid particles. Standard characterization techniques (H2 Chemisorption, BET, TPR) showed no difference between treated samples and their unpoisoned counterpart. The Fischer-Tropsch activity was investigated at industrially relevant conditions (210 °C, H2:CO = 2:1, 20 bar). The catalytic activity was significantly reduced for samples exposed to potassium, and the loss of activity was more severe with higher potassium loadings, regardless of the potassium salt used. A possible dual deactivation effect by potassium and the counter-ion (chloride, sulfate) is observed with the samples poisoned by KCl and K2SO4. The selectivity towards heavier hydrocarbons (C5+) was slightly increased with increasing potassium loading, while the CH4 selectivity was reduced for all the treated samples. The results support the idea that potassium is mobile under FT conditions. The loss of activity was described by simple deactivation models which imply a strong non-selective poisoning by the potassium species.
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21.
  •  
22.
  • Gavrilovic, Ljubisa, et al. (författare)
  • Fischer-Tropsch synthesis : Investigation of the deactivation of a Co catalyst by exposure to aerosol particles of potassium salt
  • 2018
  • Ingår i: Applied Catalysis B. - : Elsevier. - 0926-3373 .- 1873-3883. ; 230, s. 203-209
  • Tidskriftsartikel (refereegranskat)abstract
    • The influence of potassium species on a Co based Fischer-Tropsch catalyst was investigated using an aerosol deposition technique. This way of poisoning the catalyst was chosen to simulate the actual potassium behaviour during the biomass to liquid (BTL) process utilizing gasification followed by fuel synthesis. A reference catalyst was poisoned with three levels of potassium and the samples were characterized and tested for the Fischer-Tropsch reaction under industrially relevant conditions. None of the conventional characterization techniques applied (H2 Chemisorption, BET, TPR) divulged any difference between poisoned and unpoisoned samples, whereas the activity measurements showed a dramatic drop in activity following potassium deposition. The results are compared to previous results where incipient wetness impregnation was used as the method of potassium deposition. The effect of potassium is quite similar in the two cases, indicating that irrespective of how potassium is introduced it will end up in the same form and on the same location on the active surface. This indicates that potassium is mobile under FTS conditions, and that potassium species are able to migrate to sites of particular relevance for the FT reaction.
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23.
  • Gavrilovic, Lubisa, et al. (författare)
  • The effect of aerosol-deposited ash components on a cobalt-based Fischer–Tropsch catalyst
  • 2019
  • Ingår i: Reaction Kinetics, Mechanisms and Catalysis. - : Springer. - 1878-5190 .- 1878-5204. ; 127:1, s. 231-240
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of ash salts on Co-based Fisher–Tropsch catalysts was studied using an aerosol deposition technique. The major elements in the ash were found to be K, S and Cl. The ash was deposited on a calcined catalyst as dry particles with an average diameter of approx. 350 nm. The loading of ash particles was varied by varying the time of exposure to the particles in a gas stream. Catalyst characterization did not reveal significant differences in cobalt dispersion, reducibility, surface area, pore size, or pore volume between the reference and the catalysts with ash particles deposited. Activity measurements showed that following a short exposure to the mixed ash salts (30 min), there were no significant loss of activity, but a minor change in selectivity of the catalyst . Extended exposure (60 min) led to some activity loss and changes in selectivity. However, extending the exposure time and thus the amount deposited as evidenced by elemental analysis did not lead to a further drop in activity. This behavior is different from that observed with pure potassium salts, and is suggested to be related to the larger size of the aerosol particles deposited. The large aerosol particles used here were probably not penetrating the catalyst bed, and to some extent formed an external layer on the catalyst bed. The ash salts are therefore not able to penetrate to the pore structure and reach the Co active centers, but are mixed with the catalyst and detected in the elemental analysis.
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24.
  • Gawronski, J., et al. (författare)
  • Excited States of the Phthalimide Chromophore and Their Exciton Couplings: A Tool for Stereochemical Assignments
  • 1998
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 120:46, s. 12083-12091
  • Tidskriftsartikel (refereegranskat)abstract
    • The electronically excited states of the phthalimide chromophore have been studied by means of linear dichroism (LD) of samples partially oriented in poly(vinyl alcohol) films, magnetic circular dichroism (MCD), and circular dichroism (CD) spectroscopy. On the basis of the LD measurements, the low-energy tail (340-320 nm) of the first absorption band is assigned to an out-of-plane polarized pi-->pi* transition (I). At higher energy, the electronic spectrum is resolved into contributions from five pi-->pi* transitions: II(300 nm, long-axis polarized), III (275 nm, short-axis polarized), IV (235 nm, short-axis polarized), V (220 nm, long-axis polarized), and VI (similar to 210 nm, short-axis polarized). The results from semiempirical (INDO/S-CI) and ab initio (CIS/6-31+G(d)) MO calculations compare well with the proposed assignments of the excited states. Degenerate exciton interaction between electric-dipole-allowed transitions of two phthalimide chromophores is observed in the electronic absorption spectra of the achiral bis-phthalimides 2a-c and in the CD spectrum of the chiral bis-phthalimide 3a. For the latter compound, the solid-state geometry has been determined by X-ray diffraction analysis. Good agreement between experimental and computed CD spectra confirms that the coupled-oscillator exciton model provides the basis for a reliable nonempirical method for the assignment of absolute configuration for this class of compounds. Nondegenerate exciton coupling between phthalimide and benzoate or phenyl chromophores is born out in the CD spectra of homochiral molecules 3c and 3d with the rigid cyclohexane skeleton. Finally, the exciton coupling method is used to make stereochemical assignments for the acyclic, conformationally flexible derivatives 4a-c and 5b.
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25.
  • Gusarova, Viktoria, et al. (författare)
  • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
  • 2018
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9, s. 1-11
  • Tidskriftsartikel (refereegranskat)abstract
    • Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics study, with follow-up studies in 82,766 T2D cases and 498,761 controls. Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 × 10-10), lower fasting glucose, and greater insulin sensitivity. Predicted loss-of-function variants are associated with lower odds of T2D among 32,015 cases and 84,006 controls (odds ratio 0.71, 95% confidence interval 0.49-0.99, p = 0.041). Functional studies in Angptl4-deficient mice confirm improved insulin sensitivity and glucose homeostasis. In conclusion, genetic inactivation of ANGPTL4 is associated with improved glucose homeostasis and reduced risk of T2D.
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26.
  • Hauff Carlsson, Jeanette, 1965, et al. (författare)
  • Breaking the ice of low financial involvement: Does narrative information format from a trusted sender increase savings in mutual funds?
  • 2016
  • Ingår i: International Journal of Bank Marketing. - 0265-2323. ; 34:2, s. 151-170
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose – The purpose of this paper is to investigate how trust in the sender of financial information and a narrative vs fact-related format of the information influence intentions to save in a mutual fund. Design/methodology/approach – In Experiment 1, 186 undergraduates participate and in Experiment 2, 434 Swedish citizens between 18 and 70 years randomly chosen from a consumer panel. In both experiments participants are randomized to two conditions in which they are presented with the same information about a mutual fund in a narrative or a traditional fact-related format. In four different between-groups conditions crossed with information format, pre-tested descriptions of different fictitious banks are presented. The descriptions are combined in a fractional factorial design such that one bank is low in the three trust determinants of competence, benevolence and transparency, whereas the other three banks are high in one of the trust determinants but lower in the others. Ratings are made of the information with respect to how much positive affect the information evokes, interest in the message and intention to save in the mutual fund. Findings – In both experiments the narrative compared to the fact-based information format increases positive affect, interest and intention to save. Trust in the bank has an independent effect of increasing the intention to save. Practical implications – The narrative format of financial information may be key to increase involvement in financial choices but needs to be supplemented by a message that reinforces the positive affect and interest evoked by the format. Originality/value – A demonstration of how a narrative format of financial information and trust in the sender jointly influence intentions to save in a mutual fund.
  •  
27.
  •  
28.
  • Helgeland, Øyvind, et al. (författare)
  • Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth.
  • 2019
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 measurements) in the Norwegian Mother, Father, and Child Cohort Study, replicated in 5235 children, we identify a transient effect in the leptin receptor (LEPR) locus: no effect at birth, increasing effect in infancy, peaking at 6-12 months (rs2767486, P6m=2.0×10-21, β6m=0.16 sd-BMI), and little effect after age five. We identify a similar transient effect near the leptin gene (LEP), peaking at 1.5 years (rs10487505, P1.5y=1.3×10-8, β1.5y=0.079 sd-BMI). Both signals are protein quantitative trait loci for soluble-LEPR and LEP in plasma in adults independent from adult traits mapped to the respective genes, suggesting key roles of common variation in the leptin signaling pathway for healthy infant growth.
  •  
29.
  • Herrstrom, Per, et al. (författare)
  • Acute glomerulonephritis, Henoch-Schonlein purpura and dental amalgam in Swedish children: a case-control study
  • 1996
  • Ingår i: Science of the Total Environment. - 1879-1026. ; 191:3, s. 277-282
  • Tidskriftsartikel (refereegranskat)abstract
    • The issue of adverse health effects from dental amalgam and the concurrent low-dose exposure to inorganic mercury have been scrutinized by several Swedish expert groups during the past years. Only rarely have amalgam fillings in children been related to health effects. Experimental studies in genetically disposed animals have shown that low doses of inorganic mercury can induce autoimmune glomerulonephritis. The present case-control study included 31 children with acute glomerulonephritis and 33 with Henoch-Schonlein purpura retrieved from an in-patient register for the period 1973-1992 at the county hospital in Halmstad, Sweden. The median age was 10 and 9 years, respectively, for the two diagnostic groups. Dental clinics reported amalgam burden of the patients during the year before the date of diagnosis. Corresponding data were obtained for three randomly selected controls for each case, drawn from the case records of the same dental clinics, with matching for age and sex. Odds ratios (95% confidence interval) were 1.42 (0.49, 4.11) for Henoch-Schonlein purpura, 0.59 (0.25, 1.38) for acute glomerulonephritis and 0.84 (0.40, 1.75) for both diseases combined. The results of this study did not indicate increased disease risk in relation to amalgam burden.
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30.
  • Holmén, Anders, et al. (författare)
  • Direct determination of the absolute configuration of a cyclic thiolsulfinate by VCD spectroscopy
  • 2003
  • Ingår i: Tetrahedron. - : Pergamon Press. - 0957-4166 .- 1362-511X. ; 14:15, s. 2267-2269
  • Tidskriftsartikel (refereegranskat)abstract
    • Experimental and calculated vibrational circular dichroism (VCD) spectra of the enantiomers of the conformationally rigid thiolsulfinate, naphtho[1,8-cd]-1,2-dithiole 1-oxide 1, obtained by chromatographic resolution of the racemate, were in excellent agreement, showing a (+)-(S)-1/(-)-(R)-1 relationship.
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31.
  • Holmén, Anders, 1967, et al. (författare)
  • ELECTRONIC-TRANSITION DIPOLE-MOMENTS OF THE 1,N-6-ETHENOADENINE CHROMOPHORE
  • 1994
  • Ingår i: Journal of Physical Chemistry. - : American Chemical Society (ACS). - 0022-3654 .- 1541-5740. ; 98:51, s. 13460-13469
  • Tidskriftsartikel (refereegranskat)abstract
    • The electronic spectra of 1,N-6-ethenoadenine (epsilon-adenine, epsilon-A), 3-methyl-epsilon-adenine (3-me-epsilon-A), and epsilon-adenosine (epsilon-Ado) have been examined with respect to the number of electronic transitions, their intensities, and their transition moments, on the basis of measurements of UV and IR linear dichroism (LD) on samples partially oriented in stretched poly(vinyl alcohol) films, fluorescence anisotropy (FA), and magnetic circular dichroism (MCD). The experimental results are compared with semiempirical molecular orbitaI calculations. Four pi-->pi(*) transitions were found to contribute to the UV spectrum of the epsilon-adenine chromophore with the following transition moment directions (relative to the ''adenine'' pseudosymmetry long axis, counted toward N-1): +27 degrees +/- 10 degrees (I at 32 500 cm(-1)), -47 degrees +/- 5 degrees (II at 37 000 cm(-1)), -30 degrees +/- 10 degrees (III at 32 000 cm(-1)), and -11 degrees +/- 10 degrees or -49 degrees +/- 10 degrees (IV at approximate to 46 000 cm(-1)). The orientation parameters in the stretched film experiments were determined from polarized IR measurements combined with UV LD and FA data. In addition, fluorescence emission and excitation spectra and fluorescence lifetimes of E-A in aqueous solutions indicate that epsilon-A does not behave as a single spectroscopic species. In contrast to 3-me-epsilon-A and epsilon-Ado, epsilon-A displays an emission wavelength dependent excitation spectrum and a biexponential fluorescence decay. This observation is attributed to a prototropic tautomeric equilibrium between the 1-H and 3-H forms of epsilon-A.
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32.
  • Holmén, Anders, 1967, et al. (författare)
  • Electronic transition moments of 2-aminopurine
  • 1997
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 119:13, s. 3114-3121
  • Tidskriftsartikel (refereegranskat)abstract
    • The electronic spectrum of the unnatural nucleic acid base 2-aminopurine is important in order to understand the spectroscopy and photophysics of the normal DNA bases. Knowledge of transition moment directions and effective absorption components is also a prerequisite for the interpretation of emission spectra of 2-aminopurine incorporated into DNA as a probe of nucleic acid base motion or excitation energy transfer processes. Using linear dichroism, fluorescence anisotropy, and ordinary and magnetic circular dichroism techniques, the near-UV spectrum of 2-aminopurine is resolved into contributions from five electronic transitions. Four moderately strong pi-->pi* transitions (I, III, IV, and V) are observed, polarized at +53 degrees (I), -72 degrees (III), -77 degrees (IV), and +57 degrees or -67 degrees (V) relative to the short molecular axis. In addition, one weak n --> pi* transition (II) polarized perpendicular to the molecular plane has been identified. Semiempirical INDO/S calculations support these assignments.
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33.
  • Holmén, Anders, 1967 (författare)
  • Excitation and Ground-State Properties of Natural and Modified Nucleic Acid Bases
  • 1997
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The nucleic acid bases are the carriers of genetic information in DNA and RNA. They are also the main chromophores of nucleic acids and determine their optical properties and sensitivity to UV radiation. In order to understand and interpret the optical spectra and photophysical behavior of nucleic acid bases, this thesis focuses on the electronic and vibrational transition moments of the naturally occurring nucleic acid bases uracil and adenine, and two synthetic, fluorescent bases: 1,N6-ethenoadenine and 2-aminopurine. The tools have been linear dichroism, fluorescence anisotropy and magnetic circular dichroism techniques in combination with semi-empirical molecular orbital calculations of electronic spectra, and ab initio and density functional theory (DFT) calculations of vibrational spectra. The UV spectrum of adenine is concluded to derive from five .pi. - .pi.* transitions whose transition moment directions and band shapes are characterized. The presence of an .pi. - .pi.* transition occurring close to the lowest .pi. - .pi.* transition is inferred from comparisons with other purines and from quantum-chemical calculations. Such an .pi. - .pi.* transition could explain the low fluorescence quantum yield and also the relatively low photochemical reactivity of adenines. For 1,N6-ethenoadenine and 2-aminopurine, the UV spectra are resolved into contributions from four .pi. - .pi.* transitions. A most remarkable finding in 2-aminopurine is the identification of a low-lying .pi. - .pi.* transition. The determined transition moments should be useful for studies of structure and dynamics of nucleic acids based on absorption and emission anisotropy. The carbonyl stretching vibrations of 1,3-dimethyluracil are assigned to the in-phase and out-of-phase components of the carbonyl stretching motions. The transition moment directions of the strong amino-group-scissoring and ring-stretching vibrations in adenine and 2-aminopurine are expected to be useful for structural studies of nucleic acids containing adenine or 2-aminopurine bases using IR spectroscopy. Some of the purines are investigated with respect to their structures and tautomerism in solution using ab initio and DFT calculations. The results allow us to predict relative concentrations of various tautomers, and to identify possible differences between solution and gas-phase structures and those determined by crystallographic methods.
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34.
  • Holmén, Anders, et al. (författare)
  • Nutritional jejunostomy in esophagectomy for cancer, a national register-based cohort study of associations with postoperative outcomes and survival
  • 2021
  • Ingår i: Langenbeck's archives of surgery (Print). - : Springer. - 1435-2443 .- 1435-2451. ; 406:5, s. 1415-1423
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Insertion of a nutritional jejunostomy in conjunction with esophagectomy is performed with the intention to decrease the risk for postoperative malnutrition and improve recovery without adding significant catheter-related complications. However, previous research has shown no clear benefit and there is currently no consensus of practice.METHODS: All patients treated with esophagectomy due to cancer during the period 2006-2017 reported in the Swedish National Register for Esophageal and Gastric Cancer were included in this register-based cohort study from a national database. Patients were stratified into two groups: esophagectomy alone and esophagectomy with jejunostomy.RESULTS: A total of 847 patients (45.27%) had no jejunostomy inserted while 1024 patients (54.73%) were treated with jejunostomy. The groups were comparable, but some differences were seen in histological tumor type and tumor stage between the groups. No significant differences in length of hospital stay, postoperative surgical complications, Clavien-Dindo score, or 90-day mortality rate were seen. There was no evidence of increased risk for significant jejunostomy-related complications. Patients in the jejunostomy group with anastomotic leaks had a statistically significant lower risk for severe morbidity defined as Clavien-Dindo score ≥ IIIb (adjusted odds ratio 0.19, 95% CI: 0.04-0.94, P = 0.041) compared to patients with anastomotic leaks and no jejunostomy.CONCLUSION: A nutritional jejunostomy is a safe method for early postoperative enteral nutrition which might decrease the risk for severe outcomes in patients with anastomotic leaks. Nutritional jejunostomy should be considered for patients undergoing curative intended surgery for esophageal and gastro-esophageal junction cancer.
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35.
  • Holmén, Anders, 1967, et al. (författare)
  • Thermodynamics of PNA-Nucleic Acid Interactions
  • 1999
  • Ingår i: Peptide Nucleic Acids: Protocolls and Applications (eds. Peter E. Nielsen, Michael Egholm). - 1898486166 ; , s. 87-97
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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36.
  • Holmen, Anders, et al. (författare)
  • Tobacco use and caries risk among adolescents - a longitudinal study in Sweden
  • 2013
  • Ingår i: BMC Oral Health. - : Springer Science and Business Media LLC. - 1472-6831. ; 13
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Smoking and the use of smokeless tobacco have a detrimental impact on general and oral health. The relationship to dental caries is however still unclear. As caries is a multi-factorial disease with clear life-style, socio-economic and socio-demographic gradients, the tobacco use may be a co-variable in this complex rather than a direct etiological factor. Our aim was to analyze the impact of tobacco use on caries incidence among adolescents, with consideration to socio-economic variables by residency, using epidemiological data from a longitudinal study in the region of Halland, Sweden. Methods: The study population consisted of 10,068 adolescents between 16-19 years of age from whom yearly data on caries and tobacco use (cigarette smoking and use of smokeless tobacco) were obtained during the period 2006-2012. Reported DMFS increment between 16 and 19 years of age (Delta DMFS) for an individual was considered as the primary caries outcome. The outcome data were compared for self-reported never vs. ever users of tobacco, with consideration to neighborhood-level socio-economy (4 strata), baseline (i.e., 16 years of age) DMFS and sex. The region consists of 65 parishes with various socio-economic conditions and each study individual was geo-coded with respect to his/her residence parish. Neighborhood (parish-level) socio-economy was assessed by proportion of residing families with low household purchasing power. Results:Delta DMFS differed evidently between ever and never users of tobacco (mean values: 1.8 vs. 1.2; proportion with Delta DMFS > 0: 54.2% vs. 40.5%; p < 0.0001). Significant differences were observed in each neighborhood-level socio-economic stratum. Even after controlling for baseline DMFS and sex, Delta DMFS differed highly significantly between the ever and never users of tobacco (overall p < 0.0001). Conclusion: Tobacco use was clearly associated with increased caries increment during adolescence. Hence, this factor is relevant to consider in the clinical caries risk assessment of the individual patient as well as for community health plans dealing with oral health.
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37.
  • Holmen, Carolina, et al. (författare)
  • A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis
  • 2011
  • Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 17:6, s. 708-719
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: A post marketing surveillance study was conducted to evaluate safety and efficacy of natalizumab in Swedish multiple sclerosis (MS) patients since its introduction in August 2006 until March 2010. Methods: Patients were registered in the web-based Swedish MS-registry at 40 locations and evaluated every 6 months. Adverse events and clinical outcomes were recorded. Results: One thousand one hundred and fifty-two patients were included (71.4% female) and 149 patients stopped treatment; the main reason was planned pregnancy. Anti-natalizumab antibodies were found in 4.5% (52 patients) of which 1.6% displayed persistent antibodies. Serious adverse events were rare, but included three cases with progressive multifocal leukoencephalopathy (PML). There were seven fatal cases, probably unrelated to the natalizumab treatment. For relapsing-remitting MS patients (n = 901), mean Expanded Disability Status Scale (EDSS, -10.7%), Multiple Sclerosis Severity Scale (MSSS, -20.4%), Multiple Sclerosis Impact Scale (MSIS-29, physical -9.9%, psychological -13.3%) and Symbol Digit Modalities Test (SDMT, +10.7%) all showed significant improvements during 24 months of treatment with natalizumab. The Swedish web-based MS quality registry proved to function as a platform for post-marketing MS drug surveillance, providing long-term data regarding drug effects and adverse events beyond clinical trials. Conclusions: Our results indicate that natalizumab is generally well tolerated and has sustained efficacy for patients with active MS, though the risk of PML is still an important concern.
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38.
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39.
  • Holmén, Elin, et al. (författare)
  • Take-Home Naloxone and risk management from the perspective of people who survived an opioid overdose in Stockholm — An analysis informed by drug, set and setting
  • 2023
  • Ingår i: International journal of drug policy. - 0955-3959 .- 1873-4758. ; 115
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Take-Home Naloxone (THN) programs were introduced in Sweden in 2018 —a country with one of the highest rates of overdose mortality in the EU and a severe stigmatisation of people who inject drugs. This qualitative study builds on the international research that has expanded a previously narrow and medical focus on overdose deaths. It uses Zinberg’s framework to look beyond the role of the “drug ”to include the attitudes and personality of the person ( “set ”) and contextual factors ( “setting ”). This study explores the impacts of THN from the perspective of overdose survivors. Methods: Between November 2021 and May 2022 semi-structured interviews were conducted with 22 opioid overdose survivors, recruited among clients of the Stockholm needle and syringe program. All the participants had been treated with naloxone in an overdose situation. The interviews were processed through thematic analysis using deductive and inductive coding in accordance with the theoretical framework. Results: Interviewees included men and women who used different types of drugs. THN has impacted on “drug ”in terms of naloxone-induced withdrawal symptoms and peers having to deal with survivors’ emotions. Exploring “set ”revealed feelings of shame following naloxone revival for the person who overdosed. Despite such reactions, participants retained an overwhelmingly positive attitude towards THN. Participants integrated THN into their risk management practices ( “setting ”) and some acknowledged that THN provided a new way to treat overdoses without necessarily needing to interact with authorities, especially the police. Conclusion: The THN program has influenced “drug, set and setting ”for participants, providing increased safety at drug-intake and transferring overdose management and the burden of care to the community. The lived experi- ence of participants also exposes the limitations of THN indicating that there are additional unmet needs beyond THN programs, particularly in terms of “setting ”.
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40.
  • Huber, Florian, et al. (författare)
  • Remarks on the passivation of reduced Cu-, Ni-, Fe-, Co-based catalysts
  • 2006
  • Ingår i: Catalysis Letters. - : Springer Science and Business Media LLC. - 1011-372X .- 1572-879X. ; 110:3-4, s. 211-220
  • Tidskriftsartikel (refereegranskat)abstract
    • Catalysts containing metals such as Cu, Ni, Fe, Co in their reduced state are often subjected to passivation procedures prior to characterization. Passivation with N2O or O-2 to create a protective oxide layer also results in a certain degree of sub-surface oxidation. The heat released during oxidation is a critical parameter. The extent of bulk oxidation depends on the type of oxidant as well as on the size of the metal particles, as shown for copper catalysts. The final, meta-stable passivation layer requires a certain thickness to sustain exposure to ambient atmosphere. The encapsulation of metal particles in carbon is an efficient method for preserving the metallic state, as demonstrated for metallic nickel and iron with carbon nanofibers. The use of passivated samples for characterization of the active, i.e., reduced, catalyst has limited value.
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41.
  • Idoffsson, Åsa, 1968-, et al. (författare)
  • Development and validation of an instrument to measure nursing workload in the postanaesthesia care unit An observational study
  • 2020
  • Ingår i: European Journal of Anaesthesiology. - Philadelphia : LIPPINCOTT WILLIAMS & WILKINS. - 0265-0215 .- 1365-2346. ; 37:10, s. 864-873
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND There are no instruments specifically developed for the measurement of nursing workload in postanaesthesia care units (PACUs). An objective and valid instrument is essential for planning work flow and staffing in this unique hospital environment that encompasses elements of elective and acute postsurgical care. Previous studies show that increased workload is associated with increased complication rates in ICUs. Thus, workload assessment may be an important tool for improving postsurgical outcomes. OBJECTIVE The aim of this study was to develop and validate a postanaesthesia workload instrument (PAWI) for measurement of workload in PACUs for adults above 18 years of age. DESIGN Development and validation consisted of three parts: Delphi consensus to establish content validity; internal validation including feasibility, face validity and inter-rater reliability testing; and national external validation consisting of feasibility, inter-rater reliability, criterion validity, construct and face validities. SETTING PACUs in nine university and regional hospitals in Sweden. RESULTS The final instrument consisted of 11 workload domains. The response rate was 98% and overall feasibility of PAWI was 100%. Content and face validity were demonstrated by consensus after two Delphi rounds. In national external validation, good agreement between experts was demonstrated with Cohens kappa greater than 0.75 in nine domains and 0.6 to 0.74 in the remaining two domains. A significant relationship was seen between PAWI and the nine equivalents of nursing manpower use score (NEMS) (r = 0.439, P < 0.001). There were no floor or ceiling effects. There was a significant association between PAWI points and American Society of Anesthesiologists (ASA) physical status grade (P = 0.007) but not between PAWI points and age. CONCLUSION We developed and validated PAWI, an instrument for objectively measuring workload in postanaesthesia care units. PAWI demonstrated good feasibility and metric properties.
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42.
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43.
  • Lang, Niklaus P, et al. (författare)
  • Clinical research in implant dentistry : evaluation of implant-supported restorations, aesthetic and patient-reported outcomes
  • 2012
  • Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 39:Suppl 12, s. 133-138
  • Tidskriftsartikel (refereegranskat)abstract
    • The articles discussed in working group 3 dealt with specific aspects of clinical research. In this context, the literature reporting on survival and complication rates of implant-supported or implant-tooth supported restorations in longitudinal studies of at least 5 years were discussed. The second aspect dealt with the evaluation of aesthetic outcomes in clinical studies and the related index systems available. Finally, the third aspect discussed dealt with patient-reported outcome measures (PROMs). A detailed appraisal of the available methodology was presented.
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44.
  • Larsson, Glenn, et al. (författare)
  • Early Assessment of Patient´s Medical Condition in Ambulance Care Affects the Level of Care of Non Urgent Patients
  • 2016
  • Ingår i: Nursing Informatics 2016. - Amsterdam : IOS Press. - 9781614996576 - 9781614996583 ; , s. 893-894
  • Konferensbidrag (refereegranskat)abstract
    • The Rapid Emergency Triage and Treatment System (RETTS) is used by the Swedish ambulance care organization for assessment of patients medicalcondition. The aim of the present study was to evaluate prehospital assessment in collaboration with the ambulance nurse and primary health care physicians. If the patient's condition was priority GREEN by RETTS then the ambulance nurse decided to contact the primary care physicians for a dialogue and together they decided which level of care was the most appropriate for the patient's condition. © 2016 IMIA and IOS Press
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45.
  • Larsson, Glenn, et al. (författare)
  • Early prehospital assessment of non-urgent patients and outcomes at the appropriate level of care : A prospective exploratory study
  • 2017
  • Ingår i: International Emergency Nursing. - London : Elsevier. - 1755-599X .- 1878-013X. ; 32, s. 45-49
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: The Ambulance Organization of Sweden provides qualified medical assessment and treatment by ambulance nurses based on patient needs regarding appropriate levels of care. A new model for patients with non-urgent medical conditions has been introduced. The main objective of this study was to examine early prehospital assessment of non-urgent patients, and its impact on the choice of the appropriate level of care.Methods: The study design was a 1-year, prospective study, involving an ambulance district in southwestern Sweden with a population of 78,000. Eligible patients were from18 years of age, assessed as priority GREEN by Rapid Emergency Triage and Treatment System (RETTS). Ambulance nurses contacted primary care physicians on decisions on whether a patient should be transported to a primary healthcare unit or an A&E. Data was collected from electronic health records from April 2014 to July 2015. A comparison was made with a retrospective control group without consulting a physician concerning the appropriate level of care.Results: 394 patients were included, 184 in the intervention group, and 210 in the control group. There were statistically significant differences in favor of the study group (p < 0.001) regarding no transport, or transport and admission to an A&E. The groups did not differ significantly regarding transport to a primary care unit.Conclusion: This prehospital assessment model indicates a decrease in ambulance transports to an A&E and admissions to a hospital ward. Collaboration between ambulance nurses and primary physicians affects the decision for the appropriate level of care for patients with a non-urgent condition. © 2017 Elsevier Ltd
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46.
  • Lundberg, Mats, 1946- (författare)
  • Kinh Settlers in Viet Nam’s Northern Highlands : Natural Resources Management in a Cultural Context
  • 2004
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This study deals with the Kinh (or Viet) majority people who have migrated from the lowland Red River Delta to the mountainous areas of northern Viet Nam, and their adjustment to a new social and physical environment. Its aim is to analyse the social and cultural consequences for these migrants when settling in communities populated with people who belong to the national ethnic minorities (the Tày, the Giay and the Ngan peoples).Focus is on impacts in new interactive situations. The case is a special one in that it focuses on majority people's adaptation to minorities, and to a lesser extent vice versa. The Kinhs' view of how a "civilised" landscape ought to look like and how to utilise the natural resources therein demonstrated to be a central theme when discussing restructuring of the migrants' livelihood. This fact indicates the cultural dimension in the exploitation of the natural landscape and the reconstruction of the subsistence system. In the process of adaptation to a new social environment (as well as to a new physical one), social interactions between the Kinh and the ethnic minorities have proven to be important steps towards integration. One factor that turned out to be decisive in the integration process is the harmonising of life cycle ceremonies (especially weddings and funerals) between the Kinh and the minorities.New knowledge is accumulated locally, based on pooled experience. The study concerns how new knowledge on natural resources management is formed through a mixture of the migrants' knowledge from the Red River Delta and the minorities' knowledge of the local area. With a background in the delta area the Kinh brought the old knowledge of advanced wet rice production with them when migrating to the highlands.The facts show that the influence on the subsistence system has not been a one-way flow. That is, not only has the Kinh changed the minorities' agriculture system, but also the minorities' systems have had an impact on the Kinhs' system so that it now is more adapted to the conditions in the highlands.
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47.
  • Lögdberg, Sara, et al. (författare)
  • Effect of water on the space-time yield of different supported cobalt catalysts during Fischer-Tropsch synthesis
  • 2011
  • Ingår i: Applied Catalysis A. - : Elsevier BV. - 0926-860X .- 1873-3875. ; 393:1-2, s. 109-121
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of partial pressure of water on the Fischer-Tropsch (FT) rate of six cobalt-based catalysts supported on three different carrier materials (gamma-Al2O3, alpha-Al2O3, TiO2) with varying Co particle sizes was investigated in a fixed-bed reactor by changing space velocity and by external water vapour addition. A typical catalyst pellet size (<100 mu m) for industrial slurry-bed FT reactors was used. Water was found to have a positive kinetic effect, at least up to moderate amounts, on the FT rate of all catalysts in the present study, including the gamma-Al2O3-supported catalyst with pores smaller than similar to 10 nm. The reason for the apparent negative effect on the space-time yield at a direct exposure of Co supported on narrowpore gamma-Al2O3 to high partial pressures of water is due to a rapid and extensive deactivation. This could be ascribed to formation of hard-to-reduce oxidized cobalt species. The choice of support material was found to have a major effect on the response to changes in partial pressure of water, both with respect to deactivation behaviour and kinetics. However, there is a minor Co-particle size effect on the magnitude of the kinetic effect of water, larger Co particles showing a more positive response. Different extents of mass transfer limitations and/or differences in fugacities of H-2, CO and water among the six catalysts could be ruled out as causes for the observed differences.
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48.
  • Lögdberg, Sara, et al. (författare)
  • On the selectivity of cobalt-based Fischer-Tropsch catalysts : Evidence for a common precursor for methane and long-chain hydrocarbons
  • 2010
  • Ingår i: Journal of Catalysis. - : Elsevier BV. - 0021-9517 .- 1090-2694. ; 274:1, s. 84-98
  • Tidskriftsartikel (refereegranskat)abstract
    • A total of 36 cobalt-based supported catalysts were investigated in the Fischer-Tropsch reaction at industrially relevant process conditions: 483 K, 20 bar, molar H-2/CO ratio = 2.1, pellet size: 53-90 mu m. The effect of adding water vapour to the feed was investigated for 20 of the catalysts, and a H-2/CO ratio of 1.0 was used for a few catalysts. The catalysts differed in support material, Co loading, promoters, Cl content, Co particle size (larger than similar to 6 nm), morphology, degree of reduction and preparation technique and showed a large variation in selectivity. For each set of process conditions, a linear relationship seems to exist between the selectivity to methane (and other light products) and C5+ indicating a common precursor, i.e. a common monomer pool, for all hydrocarbon products. A high selectivity to C5+ is mainly an effect of a high intrinsic chain-growth probability and unlikely to be a result of an enhanced cc-olefin readsorption. The universal effect of external water addition on the hydrocarbon selectivities is limited to a decrease in the methane selectivity. A small proportion of the catalysts developed "pure methanation" sites upon exposure to high partial pressures of water.
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49.
  •  
50.
  • Matell, Henrik, et al. (författare)
  • Age-dependent effects on the treatment response of natalizumab in MS patients
  • 2015
  • Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 21:1, s. 48-56
  • Tidskriftsartikel (refereegranskat)abstract
    • Background:Natalizumab is approved for treatment of active forms of relapsing-remitting multiple sclerosis (MS) based on a pivotal phase III study comprising patients aged 18-50 years. The effect of natalizumab has not been specifically studied in older patients.Objective:We analyzed age-dependent effects on treatment-related outcome measures in 1872 patients, 189 of whom were aged 50 or more, included in the Swedish post-marketing natalizumab surveillance program.Methods:In three MS centers registry data for patients aged >50 years were validated.Results:At baseline older patients had longer disease duration, higher Expanded Disability Status Scale (EDSS) and lower Symbol Digit Modality Test (SDMT) scores than younger patients. The influence from natalizumab on outcome measures was significantly reduced and 18.7% of patients >50 years stopped treatment for lack of effect compared to 7.7% in the younger age group. At baseline, the cerebrospinal fluid levels of the chemokine CXCL13 and the leukocyte cell count were negatively correlated with age in a smaller subgroup of patients.Conclusion:These results were in agreement with previous findings suggesting that inflammation is more pronounced in younger patients and therefore the beneficial effects of potent anti-inflammatory treatments are subsiding with older ages.
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