| 1. |
- Liljeström, Monica, et al.
(författare)
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How will they react if we make them talk? : Students’ experiences from learner-created video tasks in online university education in Sweden
- 2017
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Ingår i: ICICTE 2017 Proceedings. - Rhodes, Greece : ICICTE 2017. - 9780993288982 ; , s. 318-328, s. 318-328
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Konferensbidrag (refereegranskat)abstract
- In focus in this paper are students’ views on their experiences of an educational design with oral assessment tasks supported by video technology in online university education in Sweden. Questions targeted how the students perceived the impact of oral tasks on their learning. The data were gathered through questionnaires, qualitative interviews and students’ self-reflection documents. Results indicate most students appreciated the oral assessments, and their descriptions of this learning experience indicate that the studied video-based task-design may enhance online students’ learning experiences.
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| 2. |
- Ahlford, Marianne, et al.
(författare)
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Uppsala Underdogs - A Robot Soccer Project
- 2006
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Rapport (populärvet., debatt m.m.)abstract
- In this paper, we describe the four-legged soccer team Uppsala Underdogs developed by a group of 4th year computer science students at Uppsala University during the fall of 2004. The project is based on the experience from two similar previous projects. This year the emphasis of the project has been on distribution of data and on support for evaluation and reconfiguration of strategies. To support data distribution, a middleware has been developed, which implements a replication algorithm and provides a clean interface for the other software modules (or behaviors). To enable easy reconfiguration of strategies, an automata-based graphical description language has been developed, which can be compiled into code that uses the database and the lower level modules, such as tactics and positioning, to make decisions and control the robot. In addition, a graphical simulator has been developed in which the strategies can be evaluated.
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| 3. |
- Andersson, Hanna, 1991-, et al.
(författare)
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Anchoring effect in judgments of objective fact and subjective preference
- 2021
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Ingår i: Food Quality and Preference. - : Elsevier. - 0950-3293 .- 1873-6343. ; 88
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Tidskriftsartikel (refereegranskat)abstract
- The way by which various sources of external information interact in their effects on judgment is rarely investigated. Here, we report two experiments that examine how two sources of external information—an anchor (a reference price) and an eco-label—influence judgments of an objective fact (product price) and a subjective preference (willingness-to-pay for the product). Participants’ price judgments were drawn in the direction of the anchor point, whereas the eco-label resulted in higher judgments of objective fact (Experiment 1) but did not influence subjective preference (Experiment 2). Interestingly, the eco-label seemed to strengthen the effect of the high anchor in judgments of objective fact. Further, participants with higher environmental concern answered a higher price on the subjective preference questions when they received a high anchor, as well as a lower price when they received a low anchor in comparison to the low environmental concern group. This study demonstrates that various external information sources can strengthen each other’s effects on consumer belief about products, while the effects are weaker for consumers’ preferences. The implications of the results for decision making are discussed.
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| 4. |
- Andersson, Hanna, 1991-, et al.
(författare)
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The negative footprint illusion is exacerbated by the numerosity of environment-friendly additions: unveiling the underpinning mechanisms
- 2024
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Ingår i: Journal of Cognitive Psychology. - : Taylor & Francis. - 2044-5911 .- 2044-592X. ; 36:2, s. 295-307
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Tidskriftsartikel (refereegranskat)abstract
- The addition of environmentally friendly items to conventional items sometimes leads people to believe that the carbon footprint of the entire set decreases rather than increases. This negative footprint illusion is supposedly underpinned by an averaging bias: people base environmental impact estimates not on the total impact of items but on their average. Here, we found that the illusion's magnitude increased with the addition of a greater number of "green" items when the number of conventional items remained constant (Studies 1 and 2), supporting the averaging-bias account. We challenged this account by testing what happens when the number of items in the conventional and "green" categories vary while holding the ratio between the two categories constant (Study 3). At odds with the averaging-bias account, the magnitude of the illusion increased as the category size increased, revealing a category-size bias, and raising questions about the interplay between these biases in the illusion.
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| 5. |
- Andersson, Hanna, 1991-, et al.
(författare)
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What Influences People’s Tradeoff Decisions Between CO2 Emissions and Travel Time? An Experiment With Anchors and Normative Messages
- 2021
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Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- One of the today’s greatest challenges is to adjust our behavior so that we can avoid a major climate disaster. To do so, we must make sacrifices for the sake of the environment. The study reported here investigates how anchors (extrinsic motivational-free information) and normative messages (extrinsic motivational information) influence people’s tradeoffs between travel time and carbon dioxide (CO2) emissions in the context of car travel and whether any interactions with environmental concern (an intrinsic motivational factor) can be observed. In this study, people received either a CO2, health or no normative message together with either a high anchor, a low anchor, or no anchor. People that received both a high anchor and a CO2 emission normative message were willing to travel for a longer time than those that only received a high anchor. If a low anchor was presented, no differences in willingness to travel for a longer time were found between the three different conditions of normative message groups, i.e., CO2 normative message, health normative message, or no normative message. People with higher concern for the environment were found to be willing to travel for a longer time than those with lower concern for the environment. Further, this effect was strongest when a high anchor was presented. These results suggest that anchors and normative messages are among the many factors that can influence people’s tradeoffs between CO2 emission and travel time, and that various factors may have to be combined to increase their influence over pro-environmental behavior and decisions.
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| 6. |
- Benatar, Michael, et al.
(författare)
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Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
- 2024
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 23:7, s. 687-699
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Tidskriftsartikel (refereegranskat)abstract
- Background: Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 (HSP70) co-inducer, is neuroprotective in animal models of amyotrophic lateral sclerosis, with multiple mechanisms of action, including clearance of protein aggregates, a pathological hallmark of sporadic and familial amyotrophic lateral sclerosis. We aimed to evaluate the safety and efficacy of arimoclomol in patients with amyotrophic lateral sclerosis.Methods: ORARIALS-01 was a multinational, randomised, double-blind, placebo-controlled, parallel-group trial done at 29 centres in 12 countries in Europe and North America. Patients were eligible if they were aged 18 years or older and met El Escorial criteria for clinically possible, probable, probable laboratory-supported, definite, or familial amyotrophic lateral sclerosis; had an ALS Functional Rating Scale-Revised score of 35 or more; and had slow vital capacity at 70% or more of the value predicted on the basis of the participant's age, height, and sex. Patients were randomly assigned (2:1) in blocks of 6, stratified by use of a stable dose of riluzole or no riluzole use, to receive oral arimoclomol citrate 1200 mg/day (400 mg three times per day) or placebo. The Randomisation sequence was computer generated centrally. Investigators, study personnel, and study participants were masked to treatment allocation. The primary outcome was the Combined Assessment of Function and Survival (CAFS) rank score over 76 weeks of treatment. The primary outcome and safety were analysed in the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, NCT03491462, and is completed.Findings: Between July 31, 2018, and July 17, 2019, 287 patients were screened, 245 of whom were enrolled in the trial and randomly assigned. The modified intention-to-treat population comprised 239 patients (160 in the arimoclomol group and 79 in the placebo group): 151 (63%) were male and 88 (37%) were female; mean age was 57·6 years (SD 10·9). CAFS score over 76 weeks did not differ between groups (mean 0·51 [SD 0·29] in the arimoclomol group vs 0·49 [0·28] in the placebo group; p=0·62). Cliff's delta comparing the two groups was 0·039 (95% CI –0·116 to 0·194). Proportions of participants who died were similar between the treatment groups: 29 (18%) of 160 patients in the arimoclomol group and 18 (23%) of 79 patients in the placebo group. Most deaths were due to disease progression. The most common adverse events were gastrointestinal. Adverse events were more often deemed treatment-related in the arimoclomol group (104 [65%]) than in the placebo group (41 [52%]) and more often led to treatment discontinuation in the arimoclomol group (26 [16%]) than in the placebo group (four [5%]).Interpretation: Arimoclomol did not improve efficacy outcomes compared with placebo. Although available biomarker data are insufficient to preclude future strategies that target the HSP response, safety data suggest that a higher dose of arimoclomol would not have been tolerated.Funding: Orphazyme.
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| 7. |
- Bernö, Hanna, et al.
(författare)
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Bioeconomy perception by future stakeholders: Hearing from European forestry students
- 2020
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Ingår i: AMBIO: A Journal of the Human Environment. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 49, s. 1925-1942
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Tidskriftsartikel (refereegranskat)abstract
- This article provides useful information for universities offering forestry programs and facing the growing demand for bioeconomy education. An explorative survey on bioeconomy perception among 1400 students enrolled in 29 universities across nine European countries offering forestry programs was performed. The data have been elaborated via descriptive statistics and cluster analysis. Around 70% of respondents have heard about the bioeconomy, mainly through university courses. Students perceive forestry as the most important sector for bioeconomy; however, the extent of perceived importance of forestry varies between countries, most significantly across groups of countries along a North-South European axis. Although differences across bachelor and master programs are less pronounced, they shed light on how bioeconomy is addressed by university programs and the level of student satisfaction with this. These differences and particularities are relevant for potential development routes towards comprehensive bioeconomy curricula at European forestry universities with a forestry focus.
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| 8. |
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| 9. |
- Björk Brämberg, Elisabeth, et al.
(författare)
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Increasing return-to-work among people on sick leave due to common mental disorders: design of a cluster-randomized controlled trial of a problem-solving intervention versus care-as-usual conducted in the Swedish primary health care system (PROSA)
- 2018
-
Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Common mental disorders affect about one-third of the European working-age population and are one of the leading causes of sick leave in Sweden and other OECD countries. Besides the individual suffering, the costs for society are high. This paper describes the design of a study to evaluate a work-related, problem-solving intervention provided at primary health care centers for employees on sick leave due to common mental disorders. Methods: The study has a two-armed cluster randomized design in which the participating rehabilitation coordinators are randomized into delivering the intervention or providing care-as-usual. Employees on sick leave due to common mental disorders will be recruited by an independent research assistant. The intervention aims to improve the employee's return-to-work process by identifying problems perceived as hindering return-to-work and finding solutions. The rehabilitation coordinator facilitates a participatory approach, in which the employee and the employer together identify obstacles and solutions in relation to the work situation. The primary outcome is total number of sick leave days during the 18-month follow-up after inclusion. A long-term follow-up at 36 months is planned. Secondary outcomes are short-term sick leave (min. 2 weeks and max. 12 weeks), psychological symptoms, work ability, presenteeism and health related quality of life assessed at baseline, 6 and 12-month follow-up. Intervention fidelity, reach, dose delivered and dose received will be examined in a process evaluation. An economic evaluation will put health-related quality of life and sick leave in relation to costs from the perspectives of society and health care services. A parallel ethical evaluation will focus on the interventions consequences for patient autonomy, privacy, equality, fairness and professional ethos and integrity. Discussion: The study is a pragmatic trial which will include analyses of the intervention's effectiveness, and a process evaluation in primary health care settings. Methodological strengths and challenges are discussed, such as the risk of selection bias, contamination and detection bias. If the intervention shows promising results for return-to-work, the prospects are good for implementing the intervention in routine primary health care.
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| 10. |
- Björnsson Hallgren, Hanna, 1976-, et al.
(författare)
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A specific exercise strategy for patients with subacromial pain significantly reduced the need for surgery : one-year results of a randomised controlled study
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: A specific exercise strategy focusing on eccentric exercises, for treating sbacromial pain has in a previous study been found effective at three-month followup.The aim of the present study was to investigate if the positive short-term results were maintained after one year. A further aim was to examine if baseline clinical score, rotator cuff status and radiological findings influenced the choice of surgery.Methods: 97 patients on the waiting-list for arthroscopic subacromial decompression were in the first study randomized to a three-month specific exercise strategy or unspecific exercises (controls). Patients were examined with radiology, ultrasound and assessed with clinical scores: primary Constant-Murley score. After three months of exercises the patients were asked if they still wanted surgery and this option was available until the one-year follow-up. All patients were re-assessed with clinical scores one year after inclusion or one year after surgical intervention and the number of patients that had chosen surgery in each group was compared. The baseline Constant-Murley score and the status of subacromial structures were analyzed in relation to patient's choice of surgery.Results: The positive short-term effect (improved shoulder function and pain) of the specific exercises was maintained after one-year. Compared to the three-month followup all patients had improved significantly (p < 0.0001) in Constant-Murley score. The number of patients that had chosen surgery in the control exercise group (63%) was significantly larger (p < 0.0001) than in the specific exercise group (24%). Patients that had chosen surgery had a significantly lower baseline Constant-Murley score and significantly more often a full-thickness tear. Patients with partial-thickness tears did not differ from those with intact cuff tendons.Conclusions: The positive short-term outcomes after specific exercises were maintained after one year and reduced the need of surgery significantly more than the unspecific control exercises. Patients with low baseline clinical score and/or a full-thickness tear significantly more often chose surgery.Level of evidence: I, Randomized controlled trail according to Consort statement.
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| 11. |
- Björnsson Hallgren, Hanna, et al.
(författare)
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A specific exercise strategy reduced the need for surgery in subacromial pain patients
- 2014
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group. - 0306-3674 .- 1473-0480. ; 48:19, s. 1431-1436
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose A programme based on eccentric exercises for treating subacromial pain was in a previous study found effective at 3-month follow-up. The purposes of the present study were to investigate whether the results were maintained after 1 year and whether the baseline Constant-Murley score, rotator cuff status and radiological findings influenced the outcome. Patients and methods 97 patients on the waiting list for arthroscopic subacromial decompression had been randomised to a specific exercise programme or unspecific exercises (controls). After 3 months of exercises, the patients were asked whether they still wanted surgery and this option was available until a 1-year follow-up. 1 year after inclusion or 1 year after surgery, the number of patients who decided to have surgery in each group was compared. The choice of surgery was related to the baseline Constant-Murley score, ultrasound and radiographs taken at inclusion. Results All patients had improved significantly (pless than0.0001) in the Constant-Murley score at the 1-year follow-up. Significantly more patients in the control group decided to have surgery (63%) than those in the specific exercise group (24%; pless than0.0001). Patients who decided to have surgery had a significantly lower baseline Constant-Murley score and more often a full-thickness tear. Patients with partial tears did not differ from those with intact tendons. Interpretation The positive short-term results of specific exercises were maintained after 1 year, and this exercise strategy reduces the need for surgery. Full-thickness tear and a low baseline Constant-Murley score appear to be a predictive marker for a less good outcome.
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| 12. |
- Björnsson Hallgren, Hanna C, et al.
(författare)
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Specific exercises for subacromial pain : Good results maintained for 5 years
- 2017
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Ingår i: Acta Orthopaedica. - : Taylor & Francis. - 1745-3674 .- 1745-3682. ; 88:6, s. 600-605
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose — We have previously shown that specific exercises reduced the need for surgery in subacromial painpatients at 1-year follow-up. We have now investigated whetherthis result was maintained after 5 years and compared the outcomesof surgery and non-surgical treatment.Patients and methods — 97 patients were included in the previouslyreported randomized study of patients on a waiting list forsurgery. These patients were randomized to specifi c or unspecifi cexercises. After 3 months of exercises the patients were asked ifthey still wanted surgery and this was also assessed at the present5-year follow-up. The 1-year assessment included Constant–Murley score, DASH, VAS at night, rest and activity, EQ-5D, andEQ-VAS. All these outcome assessments were repeated after 5years in 91 of the patients.Results — At the 5-year follow-up more patients in the specifi cexercise group had declined surgery, 33 of 47 as compared with16 of 44 (p = 0.001) in the unspecifi c exercise group. The meanConstant–Murley score continued to improve between the 1- and5-year follow-ups in both surgically and non-surgically treatedgroups. On a group level there was no clinically relevant changebetween 1 and 5 years in any of the other outcome measuresregardless of treatment.Interpretation — This 5-year follow-up of a previously publishedrandomized controlled trial found that specifi c exercisesreduced the need for surgery in patients with subacromial pain.Patients not responding to specifi c exercises may achieve similargood results with surgery. These fi ndings emphasize that a specifi cexercise program may serve as a selection tool for surgery.
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| 13. |
- Björnsson Hallgren, Hanna, et al.
(författare)
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Good outcome after repair of trauma-related anterosuperior rotator cuff tearsda prospective cohort study
- 2021
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Ingår i: Journal of shoulder and elbow surgery. - : MOSBY-ELSEVIER. - 1058-2746 .- 1532-6500. ; 30:7, s. 1636-1646
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Tidskriftsartikel (refereegranskat)abstract
- Background: Anterosuperior rotator cuff tears with a displaced long head of the biceps tendon are most often trauma-related, and patients with these conditions often present with severe pain and shoulder dysfunction. Repair of the subscapularis and supraspinatus and a biceps tenodesis or a tenotomy are the recommended treatments based on retrospective studies. The aim of this study was to prospectively evaluate clinical and structural treatment outcome in a cohort of trauma-related anterosuperior injuries in patients with previously healthy shoulders. Materials and methods: Patients seeking care for a suspected rotator cuff injury after shoulder trauma were screened according to a protocol including clinical examination, baseline scoring with Western Ontario Rotator Cuff Index (WORC) and numeric rating scale of pain, ultrasound, and magnetic resonance imaging (MRI). Those with anterosuperior injuries were offered surgical treatment, structured postoperative physiotherapy, and inclusion in the present study with 1-year follow-up, including MRI, baseline scores, Constant-Murley score, and Patient Global Impression of Change. Thirty-three patients (78% men) with a mean age of 59 (40-76) years were included. Results: All patients had a biceps pulley lesion, a displaced biceps tendon, and incomplete full-thickness subscapularis and supraspinatus tears. Six patients declined surgery. At follow-up, the operated patients reached a median WORC score of 86% and a median change from baseline to follow-up of 50% (P = .0001). Pain decreased (P = .0001) at rest, at night, and during activity. The median Constant-Murley score was 86% of the contralateral nonoperated shoulder, 58% of the contralateral abduction strength recovered after surgery, and 86% reported that they were recovered or much improved. All repairs and tenodeses healed except for 2 supraspinatus tendons. The 6 nonoperated patients reached a median WORC score of 90, a change in the median value from baseline to follow-up of 31, but reported more pain, and a smaller proportion considered themselves as recovered or much improved. In all patients, the 1-year MRIs had signal changes in the upper muscular portion of subscapularis, consistent with fatty infiltration, regardless of operative or nonoperative treatment. Conclusion: Anterosuperior rotator cuff injury with an associated pulley lesion and displaced long head of the biceps tendon may be treated successfully with surgery as the majority of patients in our cohort clinically recovered or were much improved without pain after a year. With a 1-year perspective, nonoperatively treated patients may also reach a reasonable clinical outcome. Independently of treatment or tendon healing, residual subscapularis muscle injury was seen, which may have long-term implications. (C) 2020 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.
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| 14. |
- Bronge, Mattias, et al.
(författare)
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Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
- 2022
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 8:17
-
Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, we screened for T cell autoreactivity against 63 CNS-expressed proteins. We identified four previously unreported autoantigens in MS: fatty acid-binding protein 7, prokineticin-2, reticulon-3, and synaptosomal-associated protein 91, which were verified to induce interferon-gamma responses in MS in two cohorts. Autoreactive profiles were heterogeneous, and reactivity to several autoantigens was MS-selective. Autoreactive T cells were predominantly CD4(+) and human leukocyte antigen-DR restricted. Mouse immunization induced antigen-specific responses and CNS leukocyte infiltration. This represents one of the largest systematic efforts to date in the search for MS autoantigens, demonstrates the heterogeneity of autoreactive profiles, and highlights promising targets for future diagnostic tools and immunomodulatory therapies in MS.
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| 15. |
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| 16. |
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| 17. |
- DAWODY, JAZAER, 1959, et al.
(författare)
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An integrated system for energy-efficient exhaust aftertreatment for heavy-duty vehicles
- 2015
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Ingår i: Renewable Energy in the Service of Mankind. - Cham : Springer International Publishing. - 9783319177779 - 9783319177762 ; 1, s. 133-143
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- © Springer International Publishing Switzerland 2015. This chapter presents a unique system approach applied in a joint academic- industrial research programme, E4 Mistra, to attain the goals of high energy efficiency and low emissions in an exhaust aftertreatment system for heavy-duty vehicles. The high energy efficiency is achieved by heat recuperation, onboard hydrogen production for NOx reduction, and by finding new solutions for making the aftertreatment system active at low exhaust temperatures. To reach low particulate emissions, a mechanical filter using a sintered metal powder is developed and coated with catalytic material to improve the soot oxidation efficiency. Low NOx emissions are achieved by an efficient NOx reduction catalyst. The integrated E4 Mistra system comprises four technological advances: thermoelectric (TE) materials for heat recuperation, catalytic reduction of NOx over innovative catalyst substrates using either the onboard diesel or biodiesel, H2 from a high-efficiency fuel reformer, and particulate filtration over a porous metal filter. The TE materials are used in a TE generator (TEG) which converts thermal energy into electricity. The TEG is used to recuperate heat from the exhaust-gas recirculation (EGR) circuit of heavy-duty trucks and is expected to generate ~1 kW electric power from 20 kW heat in the exhaust gas. The TEG is integrated in a plate heat exchanger (HEX) designed particularly for this application. Apart from the knowledge and experiences in TEG and heat exchange technologies, a thorough fluid dynamics and TE analysis are performed in this project to understand the governing processes and optimize the system accordingly. The components of the E4 Mistra system are explained in the chapter in addition to test results, which show the system's capacity for H2 production, NOx conversion, particulate matter filtration and soot oxidation, and finally electric power generation via heat recuperation from the exhaust gas using the developed TEG-HEX system.
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| 18. |
- DAWODY, JAZAER, 1959, et al.
(författare)
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E4-Mistra, a research program for the development of an energy efficient low emission exhaust aftertreatment system for heavy duty vehicles
- 2012
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Ingår i: World Renewable Energy Forum, WREF 2012, Including World Renewable Energy Congress XII and Colorado Renewable Energy Society (CRES) Annual Conference. - : American Solar Energy Society. - 9781622760923 ; , s. 4530-4536
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Konferensbidrag (refereegranskat)abstract
- This paper presents a unique system approach applied in a joint academic - industrial research program, E4 Mistra, to reach the goals of energy efficiency and low emissions exhaust aftertreatment system for heavy duty vehicles. The high energy efficiency is achieved by heat recuperation, on-board hydrogen production for use in both an auxiliary power unit and for NOx reduction and by finding new solutions for making the after-treatment system active at low exhaust temperatures. To reach low particulate emissions a mechanical filter using a sintered metal filter is developed. Low NOx emissions are achieved by an efficient NOx reduction catalyst. The system is based on four technological advances: Thermoelectric material s for heat recuperation, catalytic reduction of NOx over innovative catalyst substrates using hydrocarbons from the fuel and H2 from a high efficiency fuel reformer, and particulate filtration over a porous metal filter.
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| 19. |
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| 20. |
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| 21. |
- Finné, Martin, et al.
(författare)
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Climate in the eastern Mediterranean, and adjacent regions, during the past 6000 years - A review
- 2011
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 0305-4403 .- 1095-9238. ; 38:12, s. 3153-3173
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Forskningsöversikt (refereegranskat)abstract
- The eastern Mediterranean, with its long archaeological and historical records, provides a unique opportunity to study human responses to climate variability. We review paleoclimate data and reconstructions from the region with a focus on the last 6000 years. We aim to provide an up-to-date source of information on climate variability and to outline present limitations and future opportunities. The review work is threefold: (1) literature review, (2) spatial and temporal analysis of proxy records, and (3) statistical estimation of uncertainties in present paleoclimate reconstructions (temperature, C). On a regional scale the review reveals a wetter situation from 6000 to 5400 yrs BP (note: all ages in this paper are in calibrated years before present (i.e. before 1950), abbreviated yrs BP, unless otherwise stated). This is followed by a less wet period leading up to one of fully-developed aridity from c. 4600 yrs BP. There is a need for more high-resolution paleoclimate records, in order to (i) better understand regional patterns and trends versus local climate variability and to (ii) fill the gap of data from some regions, such as the Near East, Greece and Egypt. Further, we evaluate the regional occurrence of a proposed widespread climate event at 4200 yrs BP. This proposed climate anomaly has been used to explain profound changes in human societies at different locations in the region around this time. We suggest that although aridity was widespread around 4200 yrs BP in the eastern Mediterranean region, there is not enough evidence to support the notion of a climate event with rapidly drying conditions in this region.
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| 22. |
- Finné, Martin, 1981-
(författare)
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Climate in the eastern Mediterranean during the Holocene and beyond – A Peloponnesian perspective
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis contributes increased knowledge about climate variability during the late Quaternary in the eastern Mediterranean. Results from a paleoclimate review reveal that regional wetter conditions from 6000 to 5400 years BP were replaced by a less wet period from 5400 to 4600 years BP and to fully arid conditions around 4600 years BP. The data available, however, show that there is not enough evidence to support the notion of a widespread climate event with rapidly drying conditions in the region around 4200 years ago. The review further highlights the lack of paleoclimate data from the archaeologically rich Peloponnese Peninsula. This gap is addressed in this thesis by the provision of new paleoclimate records from the Peloponnese. One stalagmite from Kapsia Cave and two stalagmites from Glyfada Cave were dated and analyzed for stable oxygen (δ18O) and carbon (δ13C) isotopes. The Glyfada record covers a period from ~78 ka to ~37 ka and shows that the climate in this region responded rapidly to changes in temperatures over Greenland. During Greenland stadial (interstadial) conditions colder (warmer) and drier (wetter) conditions are reflected by depleted (enriched) δ13C-values in the speleothems. The Kapsia record covers a period from ~2900 to ~1100 years BP. A comparison between the modern stalagmite top isotopes and meteorological data shows that a main control on stalagmite δ18O is wet season precipitation amount. The δ18O record from Kapsia indicates cyclical humidity changes of close to 500 years, with rapid shifts toward wetter conditions followed by slowly developing aridity. Superimposed on this signal is a centennial signal of precipitation variability. A second speleothem from Kapsia with multiple horizons of fine sediments from past flood events intercalated with the calcite is used to develop a new, quick and non-destructive method for tracing flood events in speleothems by analyzing a thick section with an XRF core scanner.
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| 23. |
- Finné, Martin, et al.
(författare)
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Speleothem evidence for late Holocene climate variability and floods in Southern Greece
- 2014
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Ingår i: Quaternary Research. - : Cambridge University Press (CUP). - 0033-5894 .- 1096-0287. ; 81:2, s. 213-227
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Tidskriftsartikel (refereegranskat)abstract
- We present stable isotope data (delta O-18, delta C-13) from a detrital rich stalagmite from Kapsia Cave, the Peloponnese, Greece. The cave is rich in archeological remains and there are reasons to believe that flooding of the cave has directly affected humans using the cave. Using a combination of U-Th and C-14 dating to constrain a site-specific correction factor for (Th-232/U-238) detrital molar ratio, a linear age model was constructed. The age model shows that the stalagmite grew during the period from ca. 950 BC to ca. AD 830. The stable oxygen record from Kapsia indicates cyclical changes of close to 500 yr in precipitation amount, with rapid shifts towards wetter conditions followed by slowly developing aridity. Superimposed on this signal, wetter conditions are inferred around 850, 700, 500 and 400-100 BC, and around AD 160-300 and AD 770; and driest conditions are inferred to have occurred around 450 BC, AD 100-150 and AD 650. Detrital horizons in the stalagmite indicate that three major floods took place in the cave at 500 BC, 70 BC and AD 450. The stable carbon isotope record reflects changes in biological activity being a result of both climate and human activities. (c) 2014 University of Washington.
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| 24. |
- FitzGerald, Edward A., et al.
(författare)
-
Multiplexed experimental strategies for fragment library screening using SPR biosensors
- 2020
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Surface plasmon resonance biosensor technology (SPR) is ideally suited for fragment-based lead discovery. However, generally suitable experimental procedures or detailed protocols are lacking, especially for structurally or physico-chemically challenging targets or when tool compounds are lacking. Success depends on accounting for the features of both the target and the chemical library, purposely designing screening experiments for identification and validation of hits with desired specificity and mode-of-action, and availability of orthogonal methods capable of confirming fragment hits. By adopting a multiplexed strategy, the range of targets and libraries amenable to an SPR biosensor-based approach for identifying hits is considerably expanded. We here illustrate innovative strategies using five challenging targets and variants thereof. Two libraries of 90 and 1056 fragments were screened using two different flow-based SPR biosensor systems, allowing different experimental approaches. Practical considerations and procedures accounting for the characteristics of the proteins and libraries, and that increase robustness, sensitivity, throughput and versatility are highlighted.Competing Interest StatementAnna Moberg, Maria T. Lindgren and Claes Holmgren work for Cytiva, which produce Biacore systems.
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| 25. |
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| 26. |
- FitzGerald, Edward, et al.
(författare)
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Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
- 2024
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Ingår i: SLAS Discovery. - : Elsevier. - 2472-5560 .- 2472-5552. ; :1, s. 40-51
-
Tidskriftsartikel (refereegranskat)abstract
- Surface plasmon resonance (SPR) biosensor methods are ideally suited for fragment-based lead discovery. However, generally applicable experimental procedures and detailed protocols are lacking, especially for structurally or physico-chemically challenging targets or when tool compounds are not available. Success depends on accounting for the features of both the target and the chemical library, purposely designing screening experiments for identification and validation of hits with desired specificity and mode-of-action, and availability of orthogonal methods capable of confirming fragment hits. The range of targets and libraries amenable to an SPR biosensor-based approach for identifying hits is considerably expanded by adopting multiplexed strategies, using multiple complementary surfaces or experimental conditions. Here we illustrate principles and multiplexed approaches for using flow-based SPR biosensor systems for screening fragment libraries of different sizes (90 and 1056 compounds) against a selection of challenging targets. It shows strategies for the identification of fragments interacting with 1) large and structurally dynamic targets, represented by acetyl choline binding protein (AChBP), a Cys-loop receptor ligand gated ion channel homologue, 2) targets in multi protein complexes, represented by lysine demethylase 1 and a corepressor (LSD1/CoREST), 3) structurally variable or unstable targets, represented by farnesyl pyrophosphate synthase (FPPS), 4) targets containing intrinsically disordered regions, represented by protein tyrosine phosphatase 1B (PTP1B), and 5) aggregation-prone proteins, represented by an engineered form of human tau (tau K18M). Practical considerations and procedures accounting for the characteristics of the proteins and libraries, and that increase robustness, sensitivity, throughput and versatility are highlighted. The study shows that the challenges for addressing these types of targets is not identification of potentially useful fragments per se, but establishing methods for their validation and evolution into leads.
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| 27. |
- Ge, Zhouyang, et al.
(författare)
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Effective slip over partially filled microcavities and its possible failure
- 2018
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Ingår i: Physical Review Fluids. - : American Physical Society. - 2469-990X. ; 3:5
-
Tidskriftsartikel (refereegranskat)abstract
- Motivated by the emerging applications of liquid-infused surfaces (LIS), we study the drag reduction and robustness of transverse flows over two-dimensional microcavities partially filled with an oily lubricant. Using separate simulations at different scales, characteristic contact line velocities at the fluid-solid intersection are first extracted from nanoscale phase field simulations and then applied to micronscale two-phase flows, thus introducing a multiscale numerical framework to model the interface displacement and deformation within the cavities. As we explore the various effects of the lubncant-toouter-fluid viscosity ratio A2/A0 th(mu)over tilde( )c(mu)over tilde(1), thary number Ca, the static contact angle A> and t theta(s), filling fraction of the cavity <5, we f delta d that the effective slip is most sensitive to the parameter S. The effects of A2/A1 an(mu)over tilde( )A(mu)over tilde(a )re ge theta(s)erally intertwined but weakened if <5 < 1. delta M 1er, for an initial filling fraction S = 0.94 delta our results show that the effective slip is nearly independent of the capillary number when it is small. Further increasing Ca to about O.OIA1/A20.01(mu)over tilde(1)/(mu)over tilde(2)ntify a possible failure mode, associated with lubricants draining from the LIS, for A2/A1 A (mu)over tilde(2)1(mu)over tilde(1)V less than or similar to y viscous lubricants (e.g., A2/A1 > (mu)over tilde()),(mu)over tilde(h)owever, are immune to such failure due to their generally larger contact line velocity.
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| 28. |
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| 29. |
- Ge, Zhouyang, et al.
(författare)
-
Effective slip over partially filled microcavities and its possible failure
- 2018
-
Ingår i: Physical Review Fluids. - : APS. - 2469-990X. ; 3:5
-
Tidskriftsartikel (refereegranskat)abstract
- Motivated by the emerging applications of liquid-infused surfaces (LIS), we study the drag reduction and robustness of transverse flows over two-dimensional microcavities partially filled with an oily lubricant. Using separate simulations at different scales, characteristic contact line velocities at the fluid-solid intersection are first extracted from nanoscale phase field simulations and then applied to micronscale two-phase flows, thus introducing a multiscale numerical framework to model the interface displacement and deformation within the cavities. As we explore the various effects of the lubricant-to-outer-fluid viscosity ratio ˜?2/˜?1, the capillary number Ca, the static contact angle ??, and the filling fraction of the cavity ?, we find that the effective slip is most sensitive to the parameter ?. The effects of ˜?2/˜?1 and ?? are generally intertwined but weakened if ?<1. Moreover, for an initial filling fraction ?=0.94, our results show that the effective slip is nearly independent of the capillary number when it is small. Further increasing Ca to about 0.01˜?1/˜?2, we identify a possible failure mode, associated with lubricants draining from the LIS, for ˜?2/˜?1≲0.1. Very viscous lubricants (e.g., ˜?2/˜?1>1), however, are immune to such failure due to their generally larger contact line velocity.
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| 30. |
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| 31. |
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| 32. |
- Holmgren, Hanna
(författare)
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Modelling of Moving Contact Lines in Two-Phase Flows
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Moving contact line problems appear in many natural and industrial processes. A contact line is formed where the interface between two immiscible fluids meets a solid wall. Examples from everyday life include raindrops falling on a window and water bugs resting on water surfaces. In many cases the dynamics of the contact line affects the overall behavior of the system. Industrial applications where the contact line behavior is important include gas and oil recovery in porous media, lubrication, inkjet printing and microfluidics. Computer simulations are fundamental tools to understand and predict the behavior. In this thesis we look at numerical simulations of dynamic contact line problems. Despite their importance, the physics of moving contact lines is poorly understood. The standard Navier-Stokes equations together with the conventional no-slip boundary condition predicts a singularity in the shear stresses at the contact line. Atomistic processes at the contact line come into play, and it is necessary to include these processes in the model to resolve the singularity. In the case of capillary driven flows for example, it has been observed that the microscopic contact line dynamics has a large impact on the overall macroscopic flow.In Paper I we present a new multiscale model for numerical simulation of flow of two immiscible and incompressible fluids in the presence of moving contact points (i.e. two-dimensional problems). The paper presents a new boundary methodology based on combining a relation between the apparent contact angle and the contact point velocity, and a similarity solution for Stokes flow at a planar interface (the analytic Huh and Scriven velocity). The relation between the angle and the velocity is determined by performing separate microscopic simulations.The classical Huh and Scriven solution is only valid for flow over flat walls. In Paper II we use perturbation analysis to extend the solution to flow over curved walls. Paper III presents the parallel finite element solver that is used to perform the numerical experiments presented in this thesis. Finally, the new multiscale model (presented in Paper I) is applied to a relevant microfluidic research problem in Paper IV. For this problem it is very important to have a model that accurately takes the atomistic effects at contact lines into account.
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| 33. |
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| 34. |
- Holmgren, Hanna
(författare)
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Towards accurate modeling of moving contact lines
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis treats the numerical simulation of immiscible incompressible two-phase flows with moving contact lines. The conventional Navier–Stokes equations combined with a no-slip boundary condition leads to a non-integrable stress singularity at the contact line. The singularity in the model can be avoided by allowing the contact line to slip. Implementing slip conditions in an accurate way is not straight-forward and different regularization techniques exist where ad-hoc procedures are common. This thesis presents the first steps in developing the macroscopic part of an accurate multiscale model for a moving contact line problem in two space dimensions. It is assumed that a micro model has been used to determine a relation between the contact angle and the contact line velocity. An intermediate region is introduced where an analytical expression for the velocity field exists, assuming the solid wall is perfectly flat. This expression is used to implement boundary conditions for the moving contact line, at the macroscopic scale, along a fictitious boundary located a small distance away from the physical boundary. Model problems where the shape of the interface is constant throughout the simulation are introduced. For these problems, experiments show that the errors in the resulting contact line velocities converge with the grid size h at a rate of convergence p ≈ 2. Further, an analytical expression for the velocity field in the intermediate region for the case with a curved solid wall is derived. The derivation is based on perturbation analysis.
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| 35. |
- Holmgren, Karin Hojer, et al.
(författare)
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Interlaboratory comparison study of a chemical profiling method for methylphosphonic dichloride, a nerve agent precursor
- 2023
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Ingår i: FORENSIC CHEMISTRY. - : ELSEVIER. - 2468-1709. ; 33
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Tidskriftsartikel (refereegranskat)abstract
- An interlaboratory evaluation of a chemical profiling method for a nerve agent precursor was performed by eight chemical analytical laboratories with a wide global distribution. A set of chemical attribution signatures (i.e. impurities) present in methylphosphonic dichloride (DC) were analysed by gas chromatography-mass spectrometry (GC/MS). The GC/MS analyses were performed with the individual instrumentation and analytical methods used by the laboratories in proficiency tests organized by the Organisation for the Prohibition of Chemical Weapons (OPCW). Two batches of DC, produced by two different production routes, were dispatched together with one reference sample. By the use of a targeted MS-library, sixteen chemical attribution signatures were analysed in the DC samples. Retention indices, mass spectra and relative peak areas of the GC/MS data were evaluated. When the within batch-data of the eight laboratories were compared, similarity values of 0.720-0.995 were obtained. In addition, the two different batches had clearly unique chemical attribution profiles, as indicated by a large between batch-distance similarity values of 0.509-0.576. Retention indices showed less than +/- 14 retention index unit variation for the 16 chemical attribution signatures. This study showed the potential of getting consistent chemical profiling data over multiple laboratories by the use of retention indices for alignment of GC/MS-data. The results indicate that the GC/MS instrumentation and methods used at most OPCW designated laboratories are valid tools for the acquisition of chemical profiling data of importance for the attribution analysis to study suspected production or use of chemical warfare agents.
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| 36. |
- Holmgren, Karoline, 1970-
(författare)
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Mål, matematik och mening : om identitet i mötet med gymnasieskolans yrkesprogram
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Obtaining a final diploma is an important prerequisite for young people to avoid unemployment and exclusion. Therefore, it is worrying that every year a large group of vocational students in Sweden complete their education without obtaining a final diploma. A national survey shows that the biggest obstacle to achieving a final diploma is the compulsory mathematics course.The aim of this thesis is therefore to contribute knowledge about vocational students’ encounters with upper secondary school, with a particular focus on the mathematics course and students’ ability to achieve the goals. Central to the thesis is students’ identity formation in the environment that the upper secondary school’s vocational education entails. The thesis presents two studies that build on each other: The first study examines school staff’s descriptions of what may affects vocational students’ goal fulfillment in mathematics to provide a broad and comprehensive picture from several different school actors (teachers, student health and principals). Based on the results the second study examines vocational students’ own stories with a special focus on students’ identity formation, analyzing their narratives based on four dimensions; personal-, social-, subject- and professional dimension.Overall, the results of the two studies show that other aspects than just subject-didactic factors seem to play an important role in vocational students’ goal fulfillment in mathematics. The identity formation invocational students’ encounters with upper secondary school seems to be one such aspect: Mathematics failures during former school, the importance of vocational students’ sense of belonging together as well as discourses in school and society about vocational education, vocational students, and the subject of mathematics, have a significant impact on students’ identity formation. Being a student in upper secondary vocational education encompasses a web of relationships and connections between personal identity, social identity, subject identity, and professional identity, which means that learning as well as development takes place in all these four dimensions. Therefore, social and emotional processes as well as vocational students’ identity formation should not be forgotten in the discussion about how vocational students’ goal fulfillment in mathematics can be improved. Conclusions that can be drawn are that if school difficulties arise, i.e. that vocational students are at risk of not reaching the goals, supportive efforts should focus on all four dimensions of vocational student identity.
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| 37. |
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| 38. |
- Holmgren, Mattias, 1991-, et al.
(författare)
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Averaging bias in environmental impact estimates : Evidence from the negative footprint illusion
- 2018
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Ingår i: Journal of Environmental Psychology. - : Elsevier BV. - 0272-4944 .- 1522-9610. ; 55, s. 48-52
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we argue that unsustainable behaviors often stem from a common averaging bias when people estimate the environmental impact of a set of environmentally friendly and less friendly objects or actions. In Experiment 1, we show that people believe that the total carbon footprint of a category of items (a community of buildings in this case) is lower, rather than higher, when environmentally friendly (“green” buildings) items are added to the category, a negative footprint illusion. Experiment 2 showed that the carbon footprint estimate assigned to a category with a mix of environmentally friendly and less friendly objects (“green” and conventional buildings) is the average of its subsets (the “green” buildings and the conventional buildings, respectively), an averaging bias. A similar averaging process may underpin estimates of the environmental impact of people's own actions, explaining why people believe that environmentally friendly actions can compensate for less friendly actions.
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| 39. |
- Holmgren, Mattias, 1991-, et al.
(författare)
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Can the negative footprint illusion be eliminated by summative priming?
- 2021
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Ingår i: Journal of Cognitive Psychology. - : Taylor & Francis. - 2044-5911 .- 2044-592X. ; 33:3, s. 337-356
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Tidskriftsartikel (refereegranskat)abstract
- People’s belief that one or more environmentally friendly items that are added to a set of conventional items can reduce the total environmental impact of these items (the negative footprint illusion) could lead to unwanted environmental consequences. An averaging bias seems to underpin this illusion: people make their estimates based on the average of the environmental impact produced by the items rather than the accumulated sum. We report four studies that used various priming manipulations to explore whether people’s preoccupation to think in terms of an average can be eliminated by fostering a summative mindset. The results demonstrate that participants avoid succumbing to the negative footprint illusion when the critical judgment task is preceded by tasks that engender a summation judgment. Our evidence indicates that the negative footprint illusion can be tempered when a primed concept (summation) is used adaptively on subsequent judgments, thereby correcting for bias in environmental judgments.
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| 40. |
- Holmgren, Mattias, Doktorand, 1991-, et al.
(författare)
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Eliminating the Negative Footprint Illusion by Fostering a Summative Mindset using a Transfer Paradigm
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- People’s belief that an environmentally friendly item that is added to a set of conventional items has the ability to reduce the total environmental impact of these items could lead to unwanted environmental consequences. An averaging bias seems to underpin this negative footprint illusion: people make their estimates based on the average of the environmental impact produced by the items rather than their accumulative sum. We report a study using a problem-solving transfer paradigm to explore if this preoccupation to think in terms of an average can be eliminated by fostering a summative mindset. The results demonstrate that, participants can correctly estimate that environmental impact will increase when a “green” car is added to a set of petrol cars, but only when this task is preceded by a task that engenders a summation judgment. Our evidence indicates that the negative footprint illusion can be tempered by problem-solving transfer whereby a primed concept (summation) is used adaptively on subsequent judgments, thereby correcting for bias in environmental judgments.
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| 41. |
- Holmgren, Theresa, et al.
(författare)
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Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome : randomised controlled study
- 2012
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Ingår i: BMJ. British Medical Journal. - : BMJ Publishing Group. - 0959-8146 .- 0959-535X. ; 344, s. e787-
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression.DESIGN: Randomised, participant and single assessor blinded, controlled study.SETTING: Department of orthopaedics in a Swedish university hospital.PARTICIPANTS: 102 patients with long standing (over six months) persistent subacromial impingement syndrome in whom earlier conservative treatment had failed, recruited through orthopaedic specialists.INTERVENTIONS: The specific exercise strategy consisted of strengthening eccentric exercises for the rotator cuff and concentric/eccentric exercises for the scapula stabilisers in combination with manual mobilisation. The control exercise programme consisted of unspecific movement exercises for the neck and shoulder. Patients in both groups received five to six individual guided treatment sessions during 12 weeks. In between these supervised sessions the participants performed home exercises once or twice a day for 12 weeks.MAIN OUTCOME MEASURES: The primary outcome was the Constant-Murley shoulder assessment score evaluating shoulder function and pain. Secondary outcomes were patients' global impression of change because of treatment and decision regarding surgery.RESULTS: Most (97, 95%) participants completed the 12 week study. There was a significantly greater improvement in the Constant-Murley score in the specific exercise group than in the control exercise group (24 points (95% confidence interval 19 to 28.0) v 9 points (5 to 13); mean difference between group: 15 points (8.5 to 20.6)). Significantly more patients in the specific exercise group reported successful outcome (defined as large improvement or recovered) in the patients' global assessment of change because of treatment: 69% (35/51) v 24% (11/46); odds ratio 7.6, 3.1 to 18.9; P<0.001. A significantly lower proportion of patients in the specific exercise group subsequently chose to undergo surgery: 20% (10/51) v 63% (29/46); odds ratio 7.7, 3.1 to 19.4; P<0.001).CONCLUSION: A specific exercise strategy, focusing on strengthening eccentric exercises for the rotator cuff and concentric/eccentric exercises for the scapula stabilisers, is effective in reducing pain and improving shoulder function in patients with persistent subacromial impingement syndrome. By extension, this exercise strategy reduces the need for arthroscopic subacromial decompression within the three month timeframe used in the study.TRIAL REGISTRATION: Clinical trials NCT01037673.
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| 42. |
- Holmgren, Theresa, et al.
(författare)
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Republished research: Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome : randomised controlled study
- 2014
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group. - 0306-3674 .- 1473-0480. ; 48:19, s. 1456-1457
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- STUDY QUESTION Can a specific exercise strategy improve shoulder function and pain in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression? SUMMARY ANSWER Compared with a control exercise group, patients in the specific exercise group had significantly greater improvements in shoulder function and pain and fewer patients needed surgery at the three month assessment. WHAT IS KNOWN AND WHAT THIS PAPER ADDS Different exercise programmes are used as first line treatment in patients with subacromial impingement syndrome, but conclusive evidence to support the efficacy for these programmes is lacking. This specific exercise strategy proved effective in improving shoulder function and pain in patients in whom earlier conservative treatment had failed.
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| 43. |
- Holmgren, Theresa, et al.
(författare)
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Republished research: Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome : randomised controlled study
- 2013
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group. - 0306-3674 .- 1473-0480. ; 47:14, s. 908-908
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Study questionCan a specific exercise strategy improve shoulder function and pain in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression?Summary answerCompared with a control exercise group, patients in the specific exercise group had significantly greater improvements in shoulder function and pain and fewer patients needed surgery at the three month assessment.What is known and what this paper addsDifferent exercise programmes are used as first line treatment in patients with subacromial impingement syndrome, but conclusive evidence to support the efficacy for these programmes is lacking. This specific exercise strategy proved effective in improving shoulder function and pain in patients in whom earlier conservative treatment had failed.
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| 44. |
- Humble, Niklas, 1987-, et al.
(författare)
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Cheaters or AI-Enhanced Learners : Consequences of ChatGPT for Programming Education
- 2024
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Ingår i: Electronic Journal of e-Learning. - : Academic Publishing International Limited. - 1479-4403. ; 22:2, s. 16-29
-
Tidskriftsartikel (refereegranskat)abstract
- Artificial Intelligence (AI) and related technologies have a long history of being used in education for motivating learners and enhancing learning. However, there have also been critiques for a too uncritical and naïve implementation of AI in education (AIED) and the potential misuse of the technology. With the release of the virtual assistant ChatGPT from OpenAI, many educators and stakeholders were both amazed and horrified by the potential consequences for education. One field with a potential high impact of ChatGPT is programming education in Computer Science (CS), where creating assessments has long been a challenging task due to the vast amount of programming solutions and support on the Internet. This now appears to have been made even more challenging with ChatGPT’s ability to produce both complex and seemingly novel solutions to programming questions. With the support of data collected from interactions with ChatGPT during the spring semester of 2023, this position paper investigates the potential opportunities and threats of ChatGPT for programming education, guided by the question: What could the potential consequences of ChatGPT be for programming education? This paper applies a methodological approach inspired by analytic autoethnography to investigate, experiment, and understand a novel technology through personal experiences. Through this approach, the authors have documented their interactions with ChatGPT in field diaries during the spring semester of 2023. Topics for the questions have related to content and assessment in higher education programming courses. A total of 6 field diaries, with 82 interactions (1 interaction = 1 question + 1 answer) and additional reflection notes, have been collected and analysed with thematic analysis. The study finds that there are several opportunities and threats of ChatGPT for programming education. Some are to be expected, such as that the quality of the question and the details provided highly impact the quality of the answer. However, other findings were unexpected, such as that ChatGPT appears to be “lying” in some answers and to an extent passes the Turing test, although the intelligence of ChatGPT should be questioned. The conclusion of the study is that ChatGPT have potential for a significant impact on higher education programming courses, and probably on education in general. The technology seems to facilitate both cheating and enhanced learning. What will it be? Cheating or AI-enhanced learning? This will be decided by our actions now since the technology is already here and expanding fast.
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| 45. |
- Humble, Niklas, 1987-, et al.
(författare)
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The consequences of ChatGPT for programming education : Cheating or AI-enhanced learning?
- 2023
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Ingår i: Symposium on AI Opportunities and Challenges. - : ACI Academic Conferences International. ; , s. 15-16
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Artificial Intelligence (AI) and related technologies have a long history of being used in education for motivating learners and enhancing learning. However, there have also been critiques for a too uncritical and naïve implementation of AI in education (AIED) and the potential misuse of the technology. With the release of the virtual assistant ChatGPT from OpenAI, many educators and stakeholders were both amazed and horrified by the potential consequences for education. One field with a potential high impact of ChatGPT is programming education in Computer Science (CS), where assessments have long been challenging due to the vast amount of programming solutions and support on the Internet. This now appears to have been made even more challenging with ChatGPT’s ability to produce both complex and seemingly novel solutions to programming questions. With the support of data collected from interactions with ChatGPT during the spring semester of 2023, a study was conducted where potential opportunities and threats of ChatGPT for programming education were investigated. The question to answer was: What will the consequences be for programming education? The study applied a methodological approach inspired by action research and analytic autoethnography to investigate, experiment and understand a novel technology through personal experiences. Through this approach, the authors have documented their interactions with ChatGPT in field diaries during the spring semester of 2023. Topics for the questions have related to content and assessment in higher education programming courses. A total of 6 field diaries, with 82 interactions (1 interaction = 1 question + 1 answer) and additional reflection notes, have been collected and analysed with thematic analysis. Findings of the study include several opportunities and threats of ChatGPT for programming education. Some are to be expected, such as that the quality of the question and the details provided highly impact the quality of the answer. However, other findings were unexpected, such as that ChatGPT appears to be lying in some answers and to an extent passes the Turing test, although the intelligence of ChatGPT should be questioned. The conclusion of the study is that ChatGPT will have a significant impact on higher education programming courses, and probably on education in general. The technology seems to facilitate both cheating and enhanced learning. What will it be? Cheating or AI-enhanced learning? This will be decided by our actions now since the technology is already here and expanding fast.
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| 46. |
- Joosse, Sofie, et al.
(författare)
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Critical, Engaged and Change-oriented Scholarship in Environmental Communication. Six Methodological Dilemmas to Think with
- 2020
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Ingår i: Environmental Communication. - : Informa UK Limited. - 1752-4032 .- 1752-4040. ; 14, s. 758-771
-
Tidskriftsartikel (refereegranskat)abstract
- While calls for critical, engaged and change-oriented scholarship in environmental communication (EC) abound, few articles discuss what this may practically entail. With this article, we aim to contribute to a discussion in EC about the methodological implications of such scholarship. Based on our combined experience in EC research and drawing from a variety of academic fields, we describe six methodological dilemmas that we encounter in our research practice and that we believe are inherent to such scholarship. These dilemmas are (1) grasping communication; (2) representing others; (3) involving people in research; (4) co-producing knowledge; (5) engaging critically; and (6) relating to conflict. This article does not offer solutions to these complex dilemmas. Rather, our dilemma descriptions are meant to help researchers think through methodological issues in critical, engaged and change-oriented EC research. The article also helps to translate the dilemmas to the reality of research projects through a set of questions, aimed to support a sensitivity to, and understanding of, the dilemmas in context.
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| 47. |
- Kissopoulou, Antheia, et al.
(författare)
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Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant
- 2020
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Ingår i: ESC Heart Failure. - : Wiley. - 2055-5822. ; 7:3, s. 1210-1216
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Tidskriftsartikel (refereegranskat)abstract
- Myocarditis most often affects otherwise healthy athletes and is one of the leading causes of sudden death in children and young adults. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart muscle disorder with increased risk for paroxysmal ventricular arrhythmias and sudden cardiac death. The clinical picture of myocarditis and ARVC may overlap during the early stages of cardiomyopathy, which may lead to misdiagnosis. In the literature, we found several cases that presented with episodes of myocarditis and ended up with a diagnosis of arrhythmogenic cardiomyopathy, mostly of the left predominant type. The aim of this case presentation is to shed light upon a possible link between myocarditis, a desmoplakin (DSP) gene variant, and ARVC by describing a case of male monozygotic twins who presented with symptoms and signs of myocarditis at 17 and 18 years of age, respectively. One of them also had a recurrent episode of myocarditis. The twins and their family were extensively examined including electrocardiograms (ECG), biochemistry, multimodal cardiac imaging, myocardial biopsy, genetic analysis, repeated cardiac magnetic resonance (CMR) and echocardiography over time. Both twins presented with chest pain, ECG with slight ST-T elevation, and increased troponin T levels. CMR demonstrated an affected left ventricle with comprehensive inflammatory, subepicardial changes consistent with myocarditis. The right ventricle did not appear to have any abnormalities. Genotype analysis revealed a nonsense heterozygous variant in the desmoplakin (DSP) gene [NM_004415.2:c.2521_2522del (p.Gln841Aspfs*9)] that is considered likely pathogenic and presumably ARVC related. There was no previous family history of heart disease. There might be a common pathophysiology of ARVC, associated with desmosomal dysfunction, and myocarditis. In our case, both twins have an affected left ventricle without any right ventricular involvement, and they are carriers of a novel DSP variant that is likely associated with ARVC. The extensive inflammation of the LV that was apparent in the CMR may or may not be the primary event of ARVC. Nevertheless, our data suggest that irrespective of a possible link here to ARVC, genetic testing for arrhythmogenic cardiomyopathy might be advisable for patients with recurrent myocarditis associated with a family history of myocarditis.
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| 48. |
- Kronbichler, Martin, et al.
(författare)
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A fast massively parallel two-phase flow solver for microfluidic chip simulation
- 2018
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Ingår i: The international journal of high performance computing applications. - : SAGE Publications. - 1094-3420 .- 1741-2846. ; 32, s. 266-287
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Tidskriftsartikel (refereegranskat)abstract
- This work presents a parallel finite element solver of incompressible two-phase flow targeting large-scale simulations of three-dimensional dynamics in high-throughput microfluidic separation devices. The method relies on a conservative level set formulation for representing the fluid-fluid interface and uses adaptive mesh refinement on forests of octrees. An implicit time stepping with efficient block solvers for the incompressible Navier–Stokes equations discretized with Taylor–Hood and augmented Taylor–Hood finite elements is presented. A matrix-free implementation is used that reduces the solution time for the Navier–Stokes system by a factor of approximately three compared to the best matrix-based algorithms. Scalability of the chosen algorithms up to 32,768 cores and a billion degrees of freedom is shown.
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| 49. |
- Liljeström, Monica, 1965-, et al.
(författare)
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In search of online learning 3.0 in Higher Education : the role of theory-based process evaluation
- 2019
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Ingår i: ICICTE 2019 Proceedings. - : ICICTE 2019. ; , s. 21-30
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Konferensbidrag (refereegranskat)abstract
- In this paper, a model for theory-based process evaluation in online learning is suggested and discussed in relation to its potential as a tool to reveal strengths and weaknesses in a current course design in a fully online course in Educational Science Education. The suggested focal points in the evaluation plan at this stage of the process are based on sociocultural outlooks on learning and guided by theory-based process evaluation theory. The evaluation model will be tested for the first time in autumn 2019.
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| 50. |
- Lindvall, Hanna, et al.
(författare)
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A Holocene peat record in the central South Atlantic: an archive of precipitation changes
- 2011
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Ingår i: GFF. - : Informa UK Limited. - 2000-0863 .- 1103-5897. ; 133:3-4, s. 195-206
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Tidskriftsartikel (refereegranskat)abstract
- Peat deposits from the littoral part of the wetland 2nd Pond on Nightingale Island in the central South Atlantic have been analysed to investigate the Holocene climate development on the island and to test a hypothesis about regionally persistent humidity variations. A variety of proxies were analysed - total carbon and nitrogen, biogenic silica, diatoms, amount of organic matter, macrofossils and magnetic susceptibility - and together with the lithology they are interpreted as a record reflecting changes in humidity/precipitation. Early Holocene (10,000-8500 cal. BP) was possibly significantly drier than today, probably caused by a southerly displacement of the Southern Hemisphere Westerlies (SHW) during the Antarctic climate optimum. From 8500 cal. BP and onwards, the climate became generally more humid and surface run-off increased due to higher precipitation, possibly as an effect of increased influence from the SHW as it moved north. During this generally humid period, our data disclose a distinct pattern of recurrent centennial- to millennial-long events of increased precipitation and the results corroborate the only other study in the region with a similar humidity record. The events might represent large-scale climate oscillations in the Southern Hemisphere, such as latitudinal shifts of the SHW, but may also be related to changes in sea surface temperatures.
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