| 1. |
- Berg, Thomas, 1975-
(author)
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Medical Treatment and Grading of Bell's Palsy
- 2009
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Doctoral thesis (other academic/artistic)abstract
- The main aim of this thesis was to evaluate the effect of prednisolone and valaciclovir in a large number of Bell's palsy patients. The incidence and intensity of pain around the ear, in the face or in the neck during the first two months of palsy, and its prognostic value, was also assessed. We also investigated how study design and choice of analysis method affect the rate of facial recovery. Furthermore, the agreement between the Sunnybrook, House-Brackmann and Yanagihara facial grading systems was evaluated. From May 2001 to September 2007, a prospective, randomised, double-blind, placebo-controlled, multicentre trial with 12-month follow-up was performed in patients with Bell's palsy. Of 839 randomised patients, 829 were included in the intention-to-treat analysis; 206 received placebo plus placebo, 210 prednisolone plus placebo, 207 valaciclovir plus placebo, and 206 prednisolone plus valaciclovir. Time to recovery was significantly shorter in the 416 patients who received prednisolone compared with the 413 who did not (p<0.0001). At 12 months, 300 of 416 patients (72%) in the prednisolone group had recovered compared with 237 of 413 patients (57%) in the no prednisolone group (p<0.0001). Valaciclovir was not found to affect time to facial recovery or outcome at 12 months. Prednisolone and/or valaciclovir did not affect the incidence or intensity of pain. Presence of pain at day 11 to 17 indicated a worse prognosis for facial recovery at 12 months. We also found that recovery rates in a Bell's palsy trial are substantially affected by the choice of analysis method and definition of facial recovery. We used weighted Kappa statistics in 100 examinations of patients with facial palsy to assess the agreement between the Sunnybrook, House-Brackmann and Yanagihara scales. The highest agreement was found between the regional Sunnybrook and Yanagihara scales. An evaluative difference between the Sunnybrook and House-Brackmann systems was observed.
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| 2. |
- Åhman, Mats, et al.
(author)
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Nasal symptoms and pathophysiology in farmers
- 2001
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In: International Archives of Occupational and Environmental Health. - 0340-0131 .- 1432-1246. ; 74:4, s. 279-84
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Increased morbidity and mortality in lower airway diseases have been reported among farmers. The aim of this study was to assess upper airway problems in farmers. SUBJECTS AND METHODS: Twenty-five dairy farmers, 20 pig farmers, 21 grain farmers and 19 control subjects were studied, by use of questionnaire, skin-prick test, dynamic spirometry, nasal inspection, acoustic rhinometry (before and after a decongestant) as well as by determinations of the olfactory threshold and nasal lavage (NAL) concentrations of eosinophil cationic protein (ECP), myeloperoxidase (MPO) and albumin. RESULTS: Compared with the control group, farmers had more complaints of work-related symptoms from the lower airways, and symptoms of smell impairment, and more often had nasal polyps and hyperaemia of the nasal mucosa. They also had higher levels of MPO in NAL (especially dairy farmers and pig farmers), and a tendency to more swollen nasal mucosa and lower olfactory threshold (especially grain farmers). CONCLUSIONS: The farmers had more pathological findings in their nasal mucosa, possibly indicating effects of allergens and irritants in their work environment. More studies are needed to evaluate work environment factors causing these pathological findings in farmers.
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| 3. |
- Ahlgren, Karin, et al.
(author)
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De stora restaureringarna : Från Uppsala domkyrka till Skokloster
- 2004
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Reports (pop. science, debate, etc.)abstract
- De stora restaureringarna har varit årets tema. Genom att dokumentera och analysera teori och praktik i några av 1800- och 1900-talets största restaureringar - från genomgripande stilrestaureringar till ett mer återhållsamt och tekniskt skonsamt synsätt. Därmed får vi också ett bättre underlag även för dagens ställningstagande.Föremål för våra studier är Uppsala domkyrka, Gripsholms slott, Vreta klosterkyrka, Gustav 11I:s paviljong i Haga, Kungapalatset i Vadstena och Skoklosters slott. Vi hoppas att denna utställning skall bidra till en kritisk hållning och en ökad kunskap om restaureringskonsten, som kvalificerad yrkesuppgift, tidsspegel för historiesyn och som gestaltningsideal.
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| 4. |
- Aksoy, Samet, et al.
(author)
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Forest Biophysical Parameter Estimation via Machine Learning and Neural Network Approaches
- 2023
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In: IGARSS 2023 - 2023 IEEE International Geoscience and Remote Sensing Symposium. - : IEEE. - 9798350320107 - 9798350320091 - 9798350331745 ; , s. 2661-2664
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Conference paper (peer-reviewed)abstract
- This paper presents the first results of the ongoing development of new forest mapping methods for the Swedish national forest mapping case using Airborne Laser Scanning (ALS) data, utilizing the recent findings in machine learning (ML) and Artificial Intelligence (AI) techniques. We used Random Forest (RF) and eXtreme Gradient Boosting (XGBoost) as ML models. In addition, Neural networks (NN) based approaches were utilized in this study. ALS derived features were used to estimate the stem volume (V), above-ground biomass (AGB), basal area (B), tree height (H), stem diameter (D), and forest stand age (A). XGBoost ML algorithm outperformed RF 1 % to 3 % in the R² metric. NN model performed similar to ML model, however it is superior in the estimation of V, AGB, and B parameters.
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| 5. |
- Asplund, Monika Stenkvist, et al.
(author)
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Chemotherapy in severe nasal polyposis - a possible beneficial effect? : A report of three cases
- 2010
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In: Rhinology. - 0300-0729 .- 1996-8604. ; 48:3, s. 374-376
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Journal article (peer-reviewed)abstract
- Background: Nasal polyposis is an inflammatory process of the nasal mucosa. Treatment has changed from surgery to an anti-inflammatory approach, but neither of these treatments addresses the underlying cause. Topical steroids and occasional use of systemic steroids in patients with nasal polyposis can frequently control the polypoid disease. In a few cases, when the disease is more aggressive, the repeated application of systemic steroids together with sinus surgery is required. Material and Methods: We present our experience with one case of rheumatoid arthritis and two cases with malignant diseases, all of which were treated with chemotherapy and were also accompanied by severe nasal polyposis. All of our patients had eosinophilic polypoid disease. Various chemotherapeutic treatment schemes were utilized. Results: During chemotherapy all three patients were markedly improved symptomatically including olfaction along with a significant reduction in their nasal polyposis. Duration of remission lasted for a few months in two cases and for three years, in a third case. Conclusion: This is the first report describing the successful treatment of severe nasal polyposis with chemotherapy. Based on this experience, we suggest a phase II trial with chemotherapy, preferably "low dose" methotrexate, in patients with severe nasal polyposis.
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| 6. |
- Austeng, Dordi, et al.
(author)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Journal article (peer-reviewed)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 7. |
- Barck, Charlotte, et al.
(author)
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Does nitrogen dioxide affect inflammatory markers after nasal allergen challenge?
- 2005
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In: American Journal of Rhinology. - : SAGE Publications. - 1050-6586 .- 1539-6290. ; 19:6, s. 560-566
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Journal article (peer-reviewed)abstract
- BACKGROUND: Exposure to high ambient levels of nitrogen dioxide (NO2) enhances the bronchial inflammatory reaction to allergen in humans. We tested whether this NO2 effect occurs also in the upper airways. METHODS: Sixteen allergic subjects with rhinitis and mild asthma were exposed at rest to either purified air or 500 microg/m3 NO2 for 30 minutes, followed 4 hours later by a nasal allergen challenge. Nasal lavage was performed before air/NO2 exposure, before allergen challenge, and 1, 4 and 18 hours after allergen challenge. Symptoms were recorded. RESULTS: The percentage of eosinophils and neutrophils, eosinophil cationic protein, and myeloperoxidase were similar after exposure to air + allergen and to NO2 + allergen. We noticed a tendency to increased sneezing the day after exposure to NO2 + allergen. CONCLUSION: The priming effect of an ambient brief NO2 exposure on subsequent allergic response was not noticeable in activation of inflammatory cells and mediators in the upper airways.
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| 8. |
- Behar, Etienne, et al.
(author)
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Mass-loading of the solar wind at 67P/Churyumov-Gerasimenko : Observations and modelling
- 2016
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 596
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Journal article (peer-reviewed)abstract
- Context. The first long-term in-situ observation of the plasma environment in the vicinity of a comet, as provided by the European Rosetta spacecraft.Aims. Here we offer characterisation of the solar wind flow near 67P/Churyumov-Gerasimenko (67P) and its long term evolution during low nucleus activity. We also aim to quantify and interpret the deflection and deceleration of the flow expected from ionization of neutral cometary particles within the undisturbed solar wind.Methods. We have analysed in situ ion and magnetic field data and combined this with hybrid modeling of the interaction between the solar wind and the comet atmosphere.Results. The solar wind deflection is increasing with decreasing heliocentric distances, and exhibits very little deceleration. This is seen both in observations and in modeled solar wind protons. According to our model, energy and momentum are transferred from the solar wind to the coma in a single region, centered on the nucleus, with a size in the order of 1000 km. This interaction affects, over larger scales, the downstream modeled solar wind flow. The energy gained by the cometary ions is a small fraction of the energy available in the solar wind.Conclusions. The deflection of the solar wind is the strongest and clearest signature of the mass-loading for a small, low-activity comet, whereas there is little deceleration of the solar wind.
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| 9. |
- Behar, Etienne, et al.
(author)
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Menura : A code for simulating the interaction between a turbulent solar wind and solar system bodies
- 2022
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In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 40:3, s. 281-297
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Journal article (peer-reviewed)abstract
- Despite the close relationship between planetary science and plasma physics, few advanced numerical tools allow bridging the two topics. The code Menura proposes a breakthrough towards the self-consistent modelling of these overlapping fields, in a novel two-step approach allowing for the global simulation of the interaction between a fully turbulent solar wind and various bodies of the solar system. This article introduces the new code and its two-step global algorithm, illustrated by a first example: the interaction between a turbulent solar wind and a comet.
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| 10. |
- Behar, Etienne, et al.
(author)
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Solar wind dynamics around a comet : A 2D semi-analytical kinetic model
- 2018
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 620
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Journal article (peer-reviewed)abstract
- Aims.We aim at analytically modelling the solar wind proton trajectories during their interaction with a partially ionised cometaryatmosphere, not in terms of bulk properties of the flow but in terms of single particle dynamics.Methods.We first derive a generalised gyromotion, in which the electric field is reduced to its motional component. Steady-stateis assumed, and simplified models of the cometary density and of the electron fluid are used to express the force experienced byindividual solar wind protons during the interaction.Results.A three-dimensional (3D) analytical expression of the gyration of two interacting plasma beams is obtained. Applying it to acomet case, the force on protons is always perpendicular to their velocity and has an amplitude proportional to 1/r2. The solar winddeflection is obtained at any point in space. The resulting picture presents a caustic of intersecting trajectories, and a circular regionis found that is completely free of particles. The particles do not lose any kinetic energy and this absence of deceleration, togetherwith the solar wind deflection pattern and the presence of a solar wind ion cavity, is in good agreement with the general results of theRosettamission.Conclusions.The qualitative match between the model and thein situdata highlights how dominant the motional electric field isthroughout most of the interaction region for the solar wind proton dynamics. The model provides a simple general kinetic descriptionof how momentum is transferred between these two collisionless plasmas. It also shows the potential of this semi-analytical modelfor a systematic quantitative comparison to the data.
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| 11. |
- Bengtsson, Caroline, et al.
(author)
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Chronic rhinosinusitis impairs sleep quality : results of the GA(2)LEN study
- 2017
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In: Sleep. - : Oxford University Press. - 0161-8105 .- 1550-9109. ; 40:1
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Journal article (peer-reviewed)abstract
- STUDY OBJECTIVES: To analyse the prevalence of sleep problems in subjects with CRS and to determine whether the disease severity of CRS affects sleep quality.METHODS: Questionnaires were sent to a random sample of 45 000 adults in four Swedish cities. Questions on CRS, asthma, allergic rhinitis, co-morbidities, tobacco use, educational level and physical activity were included. CRS was defined according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) epidemiological criteria. The disease severity of CRS was defined by the number of reported CRS symptoms. Sleep quality was assessed using the Basic Nordic Sleep Questionnaire.RESULTS: Of the 26 647 subjects, 2249 (8.4%) had CRS. Reported sleep problems were 50-90% more common among subjects with CRS compared with those without or the total population. The prevalence of reported sleep problems increased in conjunction with the severity of CRS. After adjusting for gender, BMI, age, tobacco use, asthma, somatic diseases, physical activity level and educational level, participants with four symptoms of CRS (compared with subjects without CRS symptoms) displayed a higher risk of snoring (adj. OR (95% CI): 3.13 (2.22-4.41)), difficulties inducing sleep (3.98 (2.94-5.40)), difficulties maintaining sleep (3.44 (2.55-4.64)), early morning awakening (4.71 (3.47-6.38)) and excessive daytime sleepiness (4.56 (3.36-6.18)). The addition of persistent allergic rhinitis to CRS further increased the risk of sleep problems.CONCLUSIONS: Sleep problems are highly prevalent among subjects with CRS. The disease severity of CRS negatively affects sleep quality.
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| 12. |
- Bengtsson, Caroline, et al.
(author)
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Impact of nasal obstruction on sleep quality : a community-based study of women
- 2015
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In: European Archives of Oto-Rhino-Laryngology. - : Springer Science and Business Media LLC. - 0937-4477 .- 1434-4726. ; 272:1, s. 97-103
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Journal article (peer-reviewed)abstract
- The aim of the study was to analyse the impact of self-reported nasal obstruction on sleep quality in women. A community-based sample of 400 women underwent a full night of polysomnography. Airway diseases, allergies and sleep-related symptoms were assessed by questionnaires. Women with subjective nasal obstruction were subdivided into three groups: persistent nasal obstruction (PNO, n = 46), hay fever (n = 88) and nasal obstruction at night (NON, n = 30). Sleep problems and related daytime symptoms were most prevalent among women with NON. After adjusting for age, BMI, smoking and asthma, NON was an independent predictor of 'Difficulties inducing sleep due to nasal obstruction' [adjusted odds ratio (95 % CI): 89.5 (27.0-296.7)], 'Snoring' [4.2 (1.7-10.2)], 'Sweating at night' [2.6 (1.1-6.1)], 'Difficulties maintaining sleep' [2.7 (1.2-6.2)], and 'Waking up hastily gasping for breath' [32.2 (8.7-119.1)]. 'Dry mouth on awakening' [7.7 (3.2-18.4)], 'Waking up unrefreshed' [2.7 (1.2-6.0)], 'Excessive daytime sleepiness' [2.6 (1.1-6.0)], and 'Daytime nasal obstruction' [12.2 (4.8-31.2)] were also associated with NON. Persistent nasal obstruction and hay fever were both associated with some reported sleep problems due to an overlap with NON. When women with NON were excluded, only 'Daytime nasal obstruction' was still significantly associated with PNO, while hay fever was associated with 'Daytime nasal obstruction' and 'Waking up hastily gasping for breath'. There were no significant differences in objectively measured sleep variables between any of the three subgroups and the study cohort. Self-reported nasal obstruction at night in women has a significant effect on several subjective day- and nighttime symptoms, but it does not appear to affect objectively measured sleep quality.
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| 13. |
- Bengtsson, Caroline, et al.
(author)
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Sinonasal outcome test-22 and peak nasal inspiratory flow : valuable tools in obstructive sleep apnoea
- 2020
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In: Rhinology. - 0300-0729 .- 1996-8604. ; 58:4, s. 341-348
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Journal article (peer-reviewed)abstract
- Background: Sinonasal complaints contribute to low adherence to continuous positive airway pressure (CPAP) treatment. We aimed to investigate sinonasal health in obstructive sleep apnoea (OSA) patients, using the sinonasal outcome test-22 (SNOT-22), and to analyse whether SNOT-22 is affected by CPAP adherence. We also aimed to investigate whether peak nasal inspiratory flow (PNIF) was able to predict adherence to CPAP. Methods:The study population comprised 197 OSA patients (60 females) initiating CPAP treatment The SNOT-22, PNIF and the Epworth Sleepiness Scale were assessed at baseline and follow-up. One-night polygraphy, the Hospital Anxiety and Depression Scale, peak expiratory flow and health-related issues were assessed at baseline. At follow-up, the patients were categorised into adherent (>4 hours/night) and non-adherent (<4 hours/night) to CPAP treatment. Results: The average time for following up CPAP treatment was (mean +/- SD) 24.0 +/- 23.9 days and it did not differ significantly between the groups.The SNOT-22 score was elevated among all OSA patients, 36.1 +/- 19.4.There was a larger improvement in the SNOT-22 score at follow-up among adherent CPAP users compared with non-adherent users (-10.4 +/- 13.9 vs. -3.2 +/- 15.4). A PNIF value of < 100 litres/min increased the risk of non-adherence to CPAP with an adjusted odds ratio (OR) of 2.40 ((95% CI 1.16-5.00)). Conclusions: The SNOT-22 was elevated in patients with OSA, indicating a considerable sinonasal disease burden.The SNOT-22 improved with good CPAP adherence. A low PNIF value was able to predict poor CPAP adherence. Both the SNOT-22 and PNIF can be valuable tools in the evaluation of OSA patients and in the management of CPAP treatment.
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| 14. |
- Bjermer, Leif, et al.
(author)
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The complex pathophysiology of allergic rhinitis : Scientific rationale for the development of an alternative treatment option
- 2019
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In: Allergy, Asthma and Clinical Immunology. - : Springer Science and Business Media LLC. - 1710-1492. ; 15, s. 24-
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Research review (peer-reviewed)abstract
- Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes. We focus on the benefits and drawbacks of different treatment options and delivery routes for AR treatments and consider how, given what is known about AR pathophysiology and symptomatology, patients may be offered more effective treatment options for rapid, effective, and sustained AR control. In particular, we consider how a new AR preparation, MP-AzeFlu (Dymista ® , Meda, Sweden), comprising a formulation of an intranasal antihistamine (azelastine hydrochloride), an intranasal corticosteroid (fluticasone propionate), and excipients delivered in a single spray, may offer benefits over and above single and multiple AR therapy options. We review the evidence in support of this treatment across the spectrum of AR disease. The concept of AR control is also reviewed within the context of new European Union and Contre les Maladies Chroniques pour un VIeillissement Actif-Allergic Rhinitis and its Impact on Asthma initiatives.
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| 15. |
- Björklund, Patrik, et al.
(author)
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Västerås slott : Slott och borgar
- 2000
-
Reports (pop. science, debate, etc.)abstract
- En majoritet av dagens byggnadsuppgifter gäller att hantera det redan byggda. När vi står inför situationen att restaurera en befintlig byggnad är det viktigt att förstå olika tidsperioders stilideal liksom byggnadsteknik och material. Först då kan vi göra en väl avvägd analys, som tar tillvara och utvecklar de kvaliteter som byggnaderna själva besitter. Därför är utbildningen upplagd som ett växelspel mellan föreläsningar, seminarier, exkursioner och en för året vald studieuppgift.Slott och borgar har varit läsårets tema. Vi har valt att arbeta med Västerås och Örebro slott - två ganska bortglömda Vasaslott som är väl värda att lyfta fram. Särskilt har vi studerat de senaste 300 årens förändringar, som inte tidigare ägnats lika stora forskarmöda som medelitden och Vasatiden. I dessa två exempel finns en provkarta på estetiska, praktiska och tekniska ingrepp från Carl Hårlemans tid och fram till idag.Studierna har således omfattat både gestaltning, funktion och byggnadsteknik. Avsikten är att visa på kvaliteter i de omvandlingar och restaureringar som skett, men också att peka på problem och analysera olika möjligheter inför framtiden. Arbetet har skett i samarbete med Statens fastighetsverk och är tänkt att utgöra ett underlag till vårdprogram och framtida restaureringsinsatser.
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| 16. |
- Cardell, L O, et al.
(author)
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Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis.
- 2009
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In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 64:9, s. 1301-8
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Journal article (peer-reviewed)abstract
- Chronic noninfectious, nonallergic rhinitis (NINAR) is a complex syndrome with a principally unknown pathophysiology. New technology has made it possible to examine differentially expressed genes and according to network theory, genes connected by their function that might have key roles in the disease.
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| 17. |
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| 18. |
- Chaplin, John, et al.
(author)
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Varför ska du använda PROMIS? : Nytt system för patientrapporterad utfallsmått
- 2018
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Conference paper (other academic/artistic)abstract
- PROMIS är ett itembanksystem för hälso- och sjukvården. Syftet är att erbjuda moderna, patientrapporterade mått som kan användas för flertalet patientgrupper till en mycket låg kostnad och med ett nationellt supportsystem.En itembankär en modern form av elektronisk enkät som kan innehålla ett stort antal enkätfrågor. Ett datorprogram väljer ut de mest lämpade frågorna till varje person utifrån dennes svar på föregående frågor, på så sätt enkäten individanpassas.
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| 19. |
- Cornelissen, G, et al.
(author)
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Black carbon-dominated PCDD/Fs sorption to soils at a former wood impregnation site
- 2008
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In: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 72:10, s. 1455-1461
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Journal article (peer-reviewed)abstract
- The influence of black carbon (BC) on the sorption of 17 native polychlorinated-p-dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) was studied in five soil samples from a sawmill site where wood used to be impregnated with chlorophenol preservatives. The presence of BC caused measured total organic carbon (TOC)-water distribution ratios (KTOC) to be a median factor of 51 (interquartile range 18-68, n = 85) higher than modeled amorphous organic carbon (AOC)-water distribution ratios (KAOC). KTOC was a factor of 73 ± 27 above KAOC for PCDFs (n = 10) and a factor of 20 ± 13 (n = 7) for PCDDs. The reason for this difference is probably that attaining a planar configuration after sorption to BC is less thermodynamically favorable for PCDDs than for PCDFs. BC-water distribution ratios were calculated from KTOC, KAOC and BC contents, and ranged from 109.9 (2,3,7,8-Tetra-CDD) to 1011.5 l kg-1 (Octa-CDF). More than 90% of the PCDD/Fs in the soil was calculated to be BC-sorbed. Dissolved organic carbon (DOC)-water distribution ratios were measured to be in the same order of magnitude as KAOC. This study shows that strong sorption to BC should be included when assessing ecotoxicological risk or modeling transport to groundwater of PCDD/Fs in soil.
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| 20. |
- Davidsson, Åke, 1956-, et al.
(author)
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Näspolyper och den täppta näsan
- 2014
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In: Fagbladet Allergi i praksis. - Oslo, Norway : Norges Astma- og Allergiforbund. - 0806-5462. ; :2, s. 16-20
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Journal article (peer-reviewed)
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| 21. |
- Ehnhage, Anders, et al.
(author)
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Treatment of idiopathic rhinitis with kinetic oscillations : a multi-centre randomized controlled study
- 2016
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In: Acta Oto-Laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 136:8, s. 852-859
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Journal article (peer-reviewed)abstract
- Conclusions: The potential effects of KOS are still uncertain regarding the most effective air pressure to be used as well as the physiological effects on the nasal mucosa. The results of the study do not support a convincing treatment effect by KOS on IR.Objectives: Idiopathic rhinitis (IR) is a common disorder, affecting ∼10-20% of the population. A new method for treating IR, Kinetic Oscillation Stimulation (KOS), has been reported to have beneficial effects on total vasomotor symptom scores (TVRSS). The primary objective with this study was to evaluate if a mean pressure of 65 mbar, pressure amplitude of 100 mbar, and 68Hz treatment with KOS had a positive effect on total vasomotor symptom scores (TVRSS), as compared with a mean pressure of 65 mbar, pressure amplitude of 4 mbar, and 68Hz treatment in patients with idiopathic rhinitis.Methods: Two hundred and seven patients were randomized (Full Analysis Set, FAS) in the study, including five visits and lasting for approximate to 25 weeks. All patients had two treatment episodes, and all patients had at least one treatment, meant as active, with high amplitude pressure for 10min in each nostril. Group 1 had two such treatments, and Group 2 had one treatment with low amplitude pressure, initially meant as placebo, on one occasion. Because of numerical improvements in these two groups, a new control group, Group 3, was introduced. They had one new control treatment where the balloon was inserted into the nose, without any air inflation and without oscillations.Results: KOS treatment with high amplitude pressure did not have significant beneficial effects as compared to low amplitude pressure on TVRSS. Numerical improvements in TVRSS and SNOT 22 were found when comparing high and low amplitude pressure treatments with uninflated balloon treatment. However, this part of the study was initially single-blinded, and these results were secondary objectives.
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| 22. |
- Ekenbäck, Andreas, et al.
(author)
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Energetic neutral atom imaging of comets
- 2008
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 35:L05103
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Journal article (peer-reviewed)abstract
- We present the first computer simulated images of energetic neutral atoms (ENAs) produced by charge exchange between solar wind protons and cometary neutrals. Proton bulk flow and temperature from MHD simulations are used along with a model of cometary neutral densities. The emission of hydrogen ENAs from the comet is then calculated using cross sections for the charge exchange collisions. The ENA production rate is integrated along lines of sight to produce an image of the fluxes. We find detection of hydrogen ENAs feasible and most favorable at solar zenith angles between 80 and 130 degrees.
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| 23. |
- Ekenbäck, Andreas, et al.
(author)
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Energetic neutral atoms around HD 209458b : estimations of magnetospheric properties
- 2010
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In: Astrophysical Journal. - Bristol : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 709:2, s. 670-679
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Journal article (peer-reviewed)abstract
- HD 209458b is an exoplanet found to transit the disk of its parent star. Observations have shown a broad absorption signature about the Ly alpha stellar line during transit, suggesting the presence of a thick cloud of atomic hydrogen around the "hot Jupiter" HD 209458b. This work expands on an earlier work studying the production of energetic neutral atoms (ENAs) as a result of the interaction between the stellar wind and the exosphere. We present an improved flow model of HD 209458b and use stellar wind values similar to those in our solar system. We find that the ENA production is high enough to explain the observations, and we show that-using expected values for the stellar wind and exosphere-the spatial and velocity distributions of ENAs would give absorption in good agreement with the observations. We also study how the production of ENAs depends on the exospheric parameters and establish an upper limit for the obstacle standoff distance at approximately 4-10 planetary radii. Finally, we compare the results obtained for the obstacle standoff distance with existing exomagnetospheric models and show how the magnetic moment of HD 209458b can be estimated from ENA observations.
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| 24. |
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| 25. |
- Ekenbäck, Andreas, 1975-
(author)
-
Numerical modelling of ENAs from stellar wind interactions
- 2008
-
Doctoral thesis (other academic/artistic)abstract
- Energetic neutral atoms (ENAs) are produced whenever a stellar wind encounters a neutral atmosphere. If a stellar wind proton comes sufficiently close to a neutral a charge-exchange reaction may take place, transforming the proton into an ENA. Unaffected by magnetic and electric fields, ENAs provide an opportunity for global imaging of stellar wind interactions.This thesis presents methods and results of numerical modelling of stellar wind interactions. In particular it treats in depth production of ENAs at comets, Mars and the extrasolar planet HD 209458b.Sufficiently accurate numerical models of stellar wind interactions require extensive computations. Parallel computing has therefore been used throughout the work, both for fluid and particle simulations of space plasmas. This thesis describes the use of a general simulation tool, providing parallel computing for space plasma simulations.The thesis presents estimations of the magnitude and morphology of the ENA production at comets and HD 209458b. It compares the results obtained with observations and analyzes them in the light of ENA production at similar objects. Also, simulated ENA images for Mars were produced and compared to observations.
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| 26. |
- Eriksson, Jenny, 1975-, et al.
(author)
-
New ways of collecting individual travel information : Evaluation of data collection and recruitment methods
- 2018
-
Reports (other academic/artistic)abstract
- The overall purpose of the project is to conduct a demonstration study that shows how two data collection methods that have been developed to collect travel survey data perform in the field, and how they perform compared with traditional TS (i.e., postal questionnaires and/or telephone interviews). The project is also intended to provide a better understanding of the ways in which different recruitment methods of respondents can be used so that future TS can be more cost effective.The two collection methods tested consist of a mobile app and an online questionnaire with a map to assist the respondents to identify travel destinations. Three recruitment methods were used, i.e., recruitment via random sampling, a web panel, and crowdsourcing. The portion of the random sample that received an online questionnaire was divided into two groups. Half the group was given no incentive, while the other half received a gift card worth SEK 100 after answering the questioner. Those who were recruited via a web panel and were to use the mobile app were rewarded in the form of a gift card worth SEK 100 if, at minimum, they made corrections to trips made on one day registered in the mobile app. A nonresponse analysis was performed of the random sample for both the online questionnaire and the mobile app. Cost estimates for each collection method and recruitment method were also performed, as were uncertainty estimates.Overall, the study shows that the mobile app registered significantly more trips per respondent than did the online questionnaire, while the distances travelled were comparable. There are several possible interpretations of this. One is that people who responded to the online questionnaire either forget about and/or combined short trips (particularly trips made for the purposes of leisure or shopping, and using the travel modes walking and car). One presumable explanation for this is that it is easier to confirm/correct the trips that the mobile app suggests than it is to recall and enter all trips in an online questionnaire. Another possible interpretation is that people responding to different data collection methods have different travel patterns. Yet another explanation is connected to technique issues regarding the different data collection methods.
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| 27. |
- Eriksson, Jenny, 1975-, et al.
(author)
-
Nya sätt att samla in individuell resvaneinformation : Utvärdering av insamlings- och rekryteringsmetoder
- 2018
-
Reports (other academic/artistic)abstract
- Inom samverkansprogrammet Nästa generations resor och transporter, som Trafikanalys är huvudansvarig för, har man identifierat ett behov av att finna och utveckla nya lösningar för resvaneundersökningar (RVU:er). Bakgrunden till detta är bland annat sjunkande svarsfrekvenser med dagens metoder, vilket skulle kunna ge problem med representativiteten. Det anses som mycket angeläget att utveckla nya metoder för datainsamling för framtidens RVU:er, både på kort och lång sikt.Det övergripande syftet med projektet är att göra en demonstrationsstudie som visar hur två datainsamlingsmetoder som har utvecklats för att samla in resevaneundersökningsdata presterar i fält, samt hur de presterar jämfört med ”traditionell” RVU (postal enkät och/eller telefonintervjuer). Projektet syftar också till att få bättre förståelse för hur olika rekryteringsmetoder kan användas för att framtida RVU:er ska kunna bli mer kostnadseffektiva. De två insamlingsmetoder som testats är webbenkät med karta och mobilapp. Tre rekryteringsmetoder har använts och dessa är rekrytering via slumpmässigt urval, webbpanel och crowdsourcing.
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| 28. |
- Farrell, William M., et al.
(author)
-
The dust, atmosphere, and plasma at the moon
- 2024
-
In: Reviews in Mineralogy and Geochemistry, Mineralogical Society of America. - : Walter de Gruyter. - 1529-6466 .- 1943-2666. ; 89, s. 563-609
-
Journal article (peer-reviewed)
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| 29. |
- Fatemi, Shahab, et al.
(author)
-
A modelling approach to infer the solar wind dynamic pressure from magnetic field observations inside Mercury's magnetosphere
- 2018
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 614
-
Journal article (peer-reviewed)abstract
- Aims: The lack of an upstream solar wind plasma monitor when a spacecraft is inside the highly dynamic magnetosphere of Mercury limits interpretations of observed magnetospheric phenomena and their correlations with upstream solar wind variations.Methods: We used AMITIS, a three-dimensional GPU-based hybrid model of plasma (particle ions and fluid electrons) to infer the solar wind dynamic pressure and Alfvén Mach number upstream of Mercury by comparing our simulation results with MESSENGER magnetic field observations inside the magnetosphere of Mercury. We selected a few orbits of MESSENGER that have been analysed and compared with hybrid simulations before. Then we ran a number of simulations for each orbit (~30–50 runs) and examined the effects of the upstream solar wind plasma variations on the magnetic fields observed along the trajectory of MESSENGER to find the best agreement between our simulations and observations.Results: We show that, on average, the solar wind dynamic pressure for the selected orbits is slightly lower than the typical estimated dynamic pressure near the orbit of Mercury. However, we show that there is a good agreement between our hybrid simulation results and MESSENGER observations for our estimated solar wind parameters. We also compare the solar wind dynamic pressure inferred from our model with those predicted previously by the WSA-ENLIL model upstream of Mercury, and discuss the agreements and disagreements between the two model predictions. We show that the magnetosphere of Mercury is highly dynamic and controlled by the solar wind plasma and interplanetary magnetic field. In addition, in agreement with previous observations, our simulations show that there are quasi-trapped particles and a partial ring current-like structure in the nightside magnetosphere of Mercury, more evident during a northward interplanetary magnetic field (IMF). We also use our simulations to examine the correlation between the solar wind dynamic pressure and stand-off distance of the magnetopause and compare it with MESSENGER observations. We show that our model results are in good agreement with the response of the magnetopause to the solar wind dynamic pressure, even during extreme solar events. We also show that our model can be used as a virtual solar wind monitor near the orbit of Mercury and this has important implications for interpretation of observations by MESSENGER and the future ESA/JAXA mission to Mercury, BepiColombo.
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| 30. |
- Fatemi, Shahab, et al.
(author)
-
Effects of protons deflected by lunar crustal magnetic fields on the global lunar plasma environment
- 2014
-
In: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 119:8, s. 6095-6105
-
Journal article (peer-reviewed)abstract
- Solar wind plasma interaction with lunar crustal magnetic fields is different than that of magnetized bodies like the Earth. Lunar crustal fields are, for typical solar wind conditions, not strong enough to form a (bow)shock upstream but rather deflect and perturb plasma and fields. Here we study the global effects of protons reflected from lunar crustal magnetic fields on the lunar plasma environment when the Moon is in the unperturbed solar wind. We employ a three-dimensional hybrid model of plasma and an observed map of reflected protons from lunar magnetic anomalies over the lunar farside. We observe that magnetic fields and plasma upstream over the lunar crustal fields compress to nearly 120% and 160% of the solar wind, respectively. We find that these disturbances convect downstream in the vicinity of the lunar wake, while their relative magnitudes decrease. In addition, solar wind protons are disturbed and heated at compression regions and their velocity distribution changes from Maxwellian to a non-Maxwellian. Finally, we show that these features persists, independent of the details of the ion reflection by the magnetic fields.
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| 31. |
- Fatemi, Shahab, et al.
(author)
-
The effects of lunar surface plasma absorption and solar wind temperature anisotropies on the solar wind proton velocity space distributions in the low-altitude lunar plasma wake
- 2012
-
In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117:10
-
Journal article (peer-reviewed)abstract
- We study the solar wind proton velocity space distribution functions on the lunar nightside at low altitudes (∼100 km) above the lunar surface using a three-dimensional hybrid plasma solver, when the Moon is in the unperturbed solar wind. When the solar wind encounters a passive obstacle, such as the Moon, without any strong magnetic field and no atmosphere, solar wind protons that impact the obstacle's surface are absorbed and removed from the velocity space distribution functions. We show first that a hybrid model of plasma is applicable to study the low-altitude lunar plasma wake by comparing the simulation results with observations. Then we examine the effects of a solar wind bi-Maxwellian velocity space distribution function and the lunar surface plasma absorption on the solar wind protons' velocity space distribution functions and their entry in the direction parallel to the interplanetary magnetic field lines into the low-altitude lunar wake. We present a backward Liouville method for particle-in-cell solvers that improves velocity space resolution. The results show that the lunar surface plasma absorption and anisotropic solar wind velocity space distributions result in substantial changes in the solar wind proton distribution functions in the low-altitude lunar plasma wake, modifying proton number density, velocity, and temperature there. Additionally, a large temperature anisotropy is found at close distances to the Moon on the lunar nightside as a consequence of the lunar surface plasma absorption effect
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| 32. |
- Fatemi, Shahab, et al.
(author)
-
The lunar wake current systems
- 2013
-
In: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 40:1, s. 17-21
-
Journal article (peer-reviewed)abstract
- We present the lunar wake current systems when the Moon is assumed to be a non-conductive body, absorbing the solar wind plasma. We show that in the transition regions between the plasma void, the expanding rarefaction region, and the interplanetary plasma, there are three main currents flowing around these regions in the lunar wake. The generated currents induce magnetic fields within these regions and perturb the field lines there. We use a three-dimensional, self-consistent hybrid model of plasma (particle ions and fluid electrons) to show the flow of these three currents. First, we identify the different plasma regions, separated by the currents, and then we show how the currents depend on the interplanetary magnetic field direction. Finally, we discuss the current closures in the lunar wake.
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| 33. |
- Fellman, Vineta, et al.
(author)
-
One-year survival of extremely preterm infants after active perinatal care in Sweden.
- 2009
-
In: JAMA : the journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 301:21, s. 2225-33
-
Journal article (peer-reviewed)abstract
- Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling.
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| 34. |
- Felton, Adam, et al.
(author)
-
Replacing monocultures with mixed-species : Ecosystem service implications of two production forest alternatives in Sweden
- 2016
-
In: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 45:Suppl. 2, s. 124-139
-
Journal article (peer-reviewed)abstract
- Whereas there is evidence that mixed-species approaches to production forestry in general can provide positive outcomes relative to monocultures, it is less clear to what extent multiple benefits can be derived from specific mixed-species alternatives. To provide such insights requires evaluations of an encompassing suite of ecosystem services, biodiversity, and forest management considerations provided by specific mixtures and monocultures within a region. Here, we conduct such an assessment in Sweden by contrasting even-aged Norway spruce (Picea abies)-dominated stands, with mixed-species stands of spruce and birch (Betula pendula or B. pubescens), or spruce and Scots pine (Pinus sylvestris). By synthesizing the available evidence, we identify positive outcomes from mixtures including increased biodiversity, water quality, esthetic and recreational values, as well as reduced stand vulnerability to pest and pathogen damage. However, some uncertainties and risks were projected to increase, highlighting the importance of conducting comprehensive interdisciplinary evaluations when assessing the pros and cons of mixtures.
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| 35. |
- Felton, Adam, et al.
(author)
-
Replacing monocultures with mixed-species stands : Ecosystem service implications of two production forest alternatives in Sweden
- 2016
-
In: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 45, s. 124-139
-
Journal article (peer-reviewed)abstract
- Whereas there is evidence that mixed-species approaches to production forestry in general can provide positive outcomes relative to monocultures, it is less clear to what extent multiple benefits can be derived from specific mixed-species alternatives. To provide such insights requires evaluations of an encompassing suite of ecosystem services, biodiversity, and forest management considerations provided by specific mixtures and monocultures within a region. Here, we conduct such an assessment in Sweden by contrasting even-aged Norway spruce (Picea abies)-dominated stands, with mixed-species stands of spruce and birch (Betula pendula or B. pubescens), or spruce and Scots pine (Pinus sylvestris). By synthesizing the available evidence, we identify positive outcomes from mixtures including increased biodiversity, water quality, esthetic and recreational values, as well as reduced stand vulnerability to pest and pathogen damage. However, some uncertainties and risks were projected to increase, highlighting the importance of conducting comprehensive interdisciplinary evaluations when assessing the pros and cons of mixtures.
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| 36. |
- Felton, Adam, et al.
(author)
-
The tree species matters : Biodiversity and ecosystem service implications of replacing Scots pine production stands with Norway spruce.
- 2020
-
In: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 49:5, s. 1035-1049
-
Research review (peer-reviewed)abstract
- The choice of tree species used in production forests matters for biodiversity and ecosystem services. In Sweden, damage to young production forests by large browsing herbivores is helping to drive a development where sites traditionally regenerated with Scots pine (Pinus sylvestris) are instead being regenerated with Norway spruce (Picea abies). We provide a condensed synthesis of the available evidence regarding the likely resultant implications for forest biodiversity and ecosystem services from this change in tree species. Apart from some benefits (e.g. reduced stand-level browsing damage), we identified a range of negative outcomes for biodiversity, production, esthetic and recreational values, as well as increased stand vulnerability to storm, frost, and drought damage, and potentially higher risks of pest and pathogen outbreak. Our results are directly relevant to forest owners and policy-makers seeking information regarding the uncertainties, risks, and trade-offs likely to result from changing the tree species in production forests.
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| 37. |
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| 38. |
- Fransson, Johan, Professor, 1967-
(author)
-
ForestMap : The next generation of forest maps – adapting a Nordic success story across the globe
- 2022
-
Other publication (pop. science, debate, etc.)abstract
- Forests provide countless values to people and society, both in developing as in developed countries. For the developed countries, the main value has been from wood and products from wood. In many developing countries, the forest is still seen as a common right of access, supplying firewood, food and building material. Today, new societal values are provided by the forests, important to human well-being. Presumably, the most important value of the forests is that they have been identified to have a major role in global climate change, where defore station, afforestation and new strategies to actively increase carbon sequestration, are very important processes. Moreover, the forests are critical habitats for biodiversity and there is increasing evidence that biodiversity contributes to forest ecosystem functioning and the provision of ecosystem services. However, there is very little global discussion on how improved management of productive forests could contribute to mitigation of climate change and enrichment of biodiversity. If forest owners could utilize efficient decision tools for improved management and precision forest management, they would benefit with higher yield and net turnover, which in turn motivates them to further improve the management. Higher net turnover is also a motivating factor to reinvest in additional management and afforestation, hence, creating a positive loop that mitigate climate change by increased carbon sequestration and is beneficial to biodiversity. Extrapolated to the global forest estate of 3.9 billion hectares, these data suggest that about 77% of the world’s forest is owned and administered by governments, about 4% is reserved for communities, about 7% is owned by local communities, and about 12% is owned by individuals. In the above context, a fundamental need from forest stakeholders is data about the forest state and change in terms of biomass, tree species composition, and forest cover. However, depending on the stakeholder, the need of data, required accuracy, willingness to pay and need of decision support is very much variating. When also considering that many stakeholders are illiterate and may not have adequate competence to interpret data into management decisions, there is a clear need for a solution that also can strengthen equality (including gender equality)among stakeholders. The ForestMap project will provide new means for forest mapping globally and provide new open data crucial for sustainable forest management and mitigation of climate change. The overall objective is to advance the societal values of forest use by developing and evaluating a new methodology to produce forest maps across the globe. The project will develop easily applicable methods for forest map production using crowd sourced data from smartphones and remote sensing data from space- and airborne systems. Artificial Intelligence (AI) algorithms will be developed in order to produce tailor-made forest maps to stakeholder’s needs, corresponding to their willingness to pay. The societal value of the forest maps used in existing and new business models will also be explored.
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| 39. |
- Fransson, Johan, Professor, 1967-, et al.
(author)
-
ForestMap : Mapping Forest Attributes Across the Globe - First Case Study
- 2023
-
In: IGARSS 2023 - 2023 IEEE International Geoscience and Remote Sensing Symposium. - : IEEE. - 9798350320107 - 9798350331745 - 9798350320091 ; , s. 3395-3397
-
Conference paper (peer-reviewed)abstract
- This paper presents the project ForestMap – a project aiming to develop and distribute new methods, which provide the benefits of accurate forest maps to a global audience. Using the recent developments in remote sensing, machine learning, and Artificial Intelligence (AI) the goal is to export the Scandinavian success stories to a wide range of stakeholders in the world.
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| 40. |
- Fredriksson, Anna, et al.
(author)
-
Downstream Supply Chain Effects of Direct Digital Kitting in the Construction Industry
- 2023
-
In: 30th Euroma conference. ; 30
-
Conference paper (peer-reviewed)abstract
- Solutions that improve operational efficiency in the construction industry is crucial. Direct digital kitting (DDK) is suggested for enhancing supply chain performance and reducing manhours throughout the supply chain and at construction site. We examine, by a single case, the downstream impacts of DDK enabled by a digital product innovation for components of inner walls. Potentials of DDK in construction supply chains have been assessed. The study provides insights on performance effects of DDK, requirements for its implementation, and conditions that alter the effects.
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| 41. |
- Galli, André, et al.
(author)
-
The tailward flow of energetic neutral atoms observed at Mars
- 2008
-
In: Journal of Geophysical Research. - Washington : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 113
-
Journal article (peer-reviewed)abstract
- The ASPERA-3 experiment on Mars Express provides the first measurements of energetic neutral atoms (ENAs) from Mars. These measurements are used to study the global structure of the interaction of the solar wind with the Martian atmosphere. In this study we describe the tailward ENA flow observed at the nightside of Mars. After characterizing energy spectra of hydrogen ENA signals, we present composite images of the ENA intensities and compare them to theoretical predictions (empirical and MHD models). We find that the tailward flow of hydrogen ENAs is mainly generated by shocked solar wind protons. Despite intensive search, no oxygen ENAs above the instrument threshold are detected. The results challenge existing plasma models and constrain the hydrogen exospheric densities and atmospheric hydrogen and oxygen loss rates at low solar activity.
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| 42. |
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| 43. |
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| 44. |
- Gunell, Herbert, et al.
(author)
-
The infant bow shock : a new frontier at a weak activity comet
- 2018
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 619
-
Journal article (peer-reviewed)abstract
- The bow shock is the first boundary the solar wind encounters as it approaches planets or comets. The Rosetta spacecraft was able to observe the formation of a bow shock by following comet 67P/Churyumov-Gerasimenko toward the Sun, through perihelion, and back outward again. The spacecraft crossed the newly formed bow shock several times during two periods a few months before and after perihelion; it observed an increase in magnetic field magnitude and oscillation amplitude, electron and proton heating at the shock, and the diminution of the solar wind further downstream. Rosetta observed a cometary bow shock in its infancy, a stage in its development not previously accessible to in situ measurements at comets and planets.
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| 45. |
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| 46. |
- Hellström, Ann, 1959, et al.
(author)
-
Retrospective evaluation of ophthalmological and neurological outcomes for infants born before 24 weeks gestational age in a Swedish cohort
- 2022
-
In: Bmj Open. - : BMJ. - 2044-6055. ; 12:8
-
Journal article (peer-reviewed)abstract
- Objectives To retrospectively evaluate ophthalmological and neurological outcomes in a Swedish cohort of infants born before 24 weeks gestational age (GA) and explore risk factors for visual impairment. Setting Eye and paediatric clinics in Sweden. Participants Infants screened for retinopathy of prematurity (ROP) (n=399), born before 24 weeks GA, 2007-2018. Cases were excluded if ophthalmological follow-up records could not be traced. Primary and secondary outcome measures Primary outcomes were ophthalmological, including visual acuity (VA), refractive error, strabismus, nystagmus and cerebral visual impairment (CVI). Secondary outcomes comprised neonatal and neurological morbidities. Data were retrospectively retrieved from medical records. Results The 355 assessed children had a median GA of 23 weeks and 2 days and a median birth weight of 565 g. At the last available ophthalmological examination, the median age was 4.8 years (range 0.5-13.2 years). Nystagmus was recorded in 21.1%, strabismus in 34.8%, and 51.0% wore spectacles. Seventy-three of 333 (21.9%) were visually impaired, defined as being referred to a low vision clinic and/or having a VA less than 20/60 at 3.5 years of age or older. ROP treatment was a significant risk factor for visual impairment (OR 2.244, p=0.003). Visually impaired children, compared with children without visual impairment, more often had neurological deficits such as intellectual disability 63.8% versus 33.3% (p<0.001), epilepsy 21.1% versus 7.5% (p=0.001) and autism spectrum disorders 32.8% versus 20.9% (p=0.043). Nine of the 355 children had been diagnosed with CVI. Conclusions Children born before 24 weeks GA frequently had visual impairment in association with neurological deficits. CVI was rarely diagnosed. A multidisciplinary approach for the evaluation and habilitation of these vulnerable infants is warranted. National follow-up guidelines need to be developed and implemented.
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| 47. |
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| 48. |
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| 49. |
- Holmström, Christine, 1969-
(author)
-
In Search of MNC Competitive Advantage : The Role of Foreign Subsidiaries as Creators and Disseminators of Knowledge
- 2004
-
Doctoral thesis (other academic/artistic)abstract
- Research on the multinational corporation (MNC) has highlighted the development of knowledge that occurs in geographically dispersed subsidiaries, and several scholars have emphasized the significance of subsidiary knowledge for the success of the MNC. This thesis contributes to the understanding of how knowledge is developed within MNC subsidiaries and how the development of subsidiary knowledge is related to the transfer of subsidiary knowledge and subsidiary impact on the performance of the larger MNC.The empirical setting consists of a combination of quantitative and qualitative data. The results of the empirical studies suggest that the development of subsidiary knowledge is contingent upon the business conditions within the local environment and, in particularly, interactive learning within relationships with important business actors external to the organization. Furthermore, the findings show that the development of knowledge within these subsidiaries is driven not only by external actors, but also by business relationships within the corporation. The results reveal that, whether a subsidiary learns and develops knowledge from external or internal sources has direct implications on how the knowledge can be used and applied by other units within the MNC, which in turn affects the extent to which the subsidiary can contribute to the performance of the MNC. It is also revealed that the barriers to transfer are especially manifest in situations in which a subsidiary is deeply embedded in relationships with demanding customers or suppliers. Thus, the embeddedness of subsidiaries in external relationships is a constraining factor for knowledge transfer. In situations in which the subsidiary is deeply embedded in its local market, the headquarters can influence the transfer across subsidiaries through the use of means such as centres of excellence.
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| 50. |
- Holmström, Kristina, et al.
(author)
-
Economic incentives for preserving biodiverse semi-natural pastures with calves from dairy cows
- 2021
-
In: Journal for Nature Conservation. - : Elsevier BV. - 1617-1381 .- 1618-1093. ; 62
-
Journal article (peer-reviewed)abstract
- Economical profitability of pasture-based beef production is necessary for continued maintenance of semi-natural pastures. In a situation of decreased cattle stocks, there is a potential to castrate male calves from dairy cows and raise them as grazing steers instead of intact bulls reared indoors, which is the common way in the Nordic countries. We examined the profitability in model enterprises with either grazing steers or indoor bulls. Within the two genders (steer and bull), there were animals of two breed types (pure dairy breed and dairy x beef crossbreed), which were divided into an intensive or extensive production system. The intensive steer system had one summer on grass and slaughter at 21 months of age whereas the extensive steer system had two summers on grass and slaughter at 28 months of age. All bulls were reared indoors and slaughtered at 15 or 18 months of age. The profitability was calculated as contribution margin (CM; sigma revenues - sigma variable costs) in three different herd sizes (50, 100 and 150 slaughtered animals per year) and in three different regions in Sweden (the southern forest districts Gsk, the southern plain districts Gns, and the lower parts of the northern Nn). In the basic calculation, CM for all steers in large herds with 150 slaughtered animals per year was above zero for all cases in Gns, and for one case in Nn and in Gsk respectively. However, all steer cases had lower CM than the comparable bull system in the basic calculation. Sensitivity analyses demonstrate several possible ways of increasing the competitiveness of the grazing steers, compared to the bulls. Utilization of buildings without opportunity cost resulted in a CM above zero for all cases. Increasing the proportion of semi-natural pastures rendering high agrienvironmental payment and support was another effective mean. Decreasing the winter feed cost and labour demand on pasture reduced the costs, whereas producing premium-price certified pasture beef increased the revenue, all measures further contributing to an improved profitability. Pasture-based beef production from dairy-born steers can be economically viable, especially in large herds and with extensive production systems. Thereby, we conclude this system to has a potential to graze large areas of semi-natural pastures and thereby conserve their biodiversity and cultural values.
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