| 1. |
- Bramklev, Caroline, et al.
(författare)
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Increasing competitiveness through concurrent development of product and packaging
- 2004
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Ingår i: Proceedings of the TMCE 2004. ; , s. 855-868
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Konferensbidrag (refereegranskat)abstract
- Extending the product development process to also include the concurrent design of product and packaging is expected to increase efficiency and effectiveness in the development process. Apart from the obvious advantage of reducing the lead times of the development project, improving environmental impact by reducing the consumption of raw material due to the possibility of facilitating a "tailor made" packaging of the product is also anticipated. For the development of the product-to-be, the packaging might provide alternative, less costly, solutions. The main objective is to establish the actual interest in or need for introducing concurrent development of product and package in the product development process. In this paper the findings from a literature review and two surveys are reported. The surveys are performed in 40 Swedish companies, half of them in the food industry and the other half in the pharmaceutical industry. From an overall perspective of competitiveness, the findings demonstrate not only the relevance of introducing concurrent development of product and packaging in the product development process, but also that this introduction should be based on the concept of integration.
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| 2. |
- Büki, Andras, 1966-, et al.
(författare)
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Peptidergic innervation of human cerebral blood vessels and saccular aneurysms
- 1999
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Ingår i: Acta Neuropathologica. - : Springer. - 0001-6322 .- 1432-0533. ; 98:4, s. 383-388
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Tidskriftsartikel (refereegranskat)abstract
- Peptidergic innervation of the human cerebral vasculature has not yet been described in detail and its role in the maintenance of cerebral autoregulation still needs to be established. Similarly, few data exist on the innervation of vascular malformations. The aim of this study was to clarify the peptidergic innervation patterns of human cerebral arteries of various sizes, and, for the first time, that of saccular aneurysms. Light microscopic study of whole-mount preparations of human cerebral arteries and aneurysm sacs resected either during tumor removal or after neck-clipping were carried out by means of silver-intensified light microscopic immunocytochemistry visualizing neuropeptide-Y, calcitonin gene-related peptide and substance P immunoreactivity. Systematic morphological investigations confirmed the presence of longitudinal fiber bundles on the adventitia and a network-like deeper peptidergic system at the adventitia-media border, while in smaller pial and intraparenchymal vessels, only sparse longitudinal immunopositive axons could be detected. The innervation pattern was totally absent in the wall of saccular aneurysms with the complete disappearance of peptidergic nerve fibers in some areas. To the best of our knowledge neither the disappearance of this network on small pial and intraparenchymal vessels, nor the absence of an innervation pattern in saccular aneurysms have been described before. Nonhomogeneous peptidergic innervation of the human cerebral vascular tree might be one of the factors responsible for the distinct autoregulatory properties of the capacitance and resistance vessels. Malfunction of this vasoregulatory system might lead to the impairment of autoregulation during pathological conditions such as subarachnoid hemorrhage.
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| 3. |
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| 4. |
- Horváth, Gábor, et al.
(författare)
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Experimental evidence that stripes do not cool zebras
- 2018
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- There are as many as 18 theories for the possible functions of the stripes of zebras, one of which is to cool the animal. We performed field experiments and thermographic measurements to investigate whether thermoregulation might work for zebra-striped bodies. A zebra body was modelled by water-filled metal barrels covered with horse, cattle and zebra hides and with various black, white, grey and striped patterns. The barrels were installed in the open air for four months while their core temperature was measured continuously. Using thermography, the temperature distributions of the barrel surfaces were compared to those of living zebras. The sunlit zebra-striped barrels reproduced well the surface temperature characteristics of sunlit zebras. We found that there were no significant core temperature differences between the striped and grey barrels, even on many hot days, independent of the air temperature and wind speed. The average core temperature of the barrels increased as follows: White cattle, grey cattle, real zebra, artificial zebra, grey horse, black cattle. Consequently, we demonstrate that zebra-striped coats do not keep the body cooler than grey coats challenging the hypothesis of a thermoregulatory role of zebra stripes.
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| 5. |
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| 6. |
- Motte, Damien, et al.
(författare)
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Assessment framework for a methodology under development – Application to the PDA methodology
- 2016
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Ingår i: Proceedings of the 11th International Symposium on Tools and Methods of Competitive Engineering - TMCE'16. - 9789461866356 ; , s. 373-388
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Konferensbidrag (refereegranskat)abstract
- This paper presents an assessment framework for methodologies under development. It is adapted from the evaluation framework for the design of an engineering model developed by Ben Ahmed and colleagues [1]. The assessment framework allows to take into account in a systematic way characteristics (that is, main categories or classes of potential requirements) that are of importance for the assessment of the quality a methodology, beyond effectiveness and efficiency. The framework is intended to be employed similarly to engineering design requirements checklists: ensuring first that no important characteristics are left out; deriving from these characteristics more specific requirements when necessary; using these characteristics or the derived requirements both to drive the development of the methodology and as evaluation criteria to assess the elements of the developed methodology. These characteristics can then be screened again as the methodology is improved. As the methodology is being developed, the assessments can go from wide and qualitative to more stringent. The framework is applied to assess the predictive design analysis (PDA) methodology.[1] Ben Ahmed, W., Mekhilef, M., Yannou, B., and Bigand, M., (2010), "Evaluation framework for the design of an engineering model", Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 24(1), pp. 107-125.
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| 7. |
- Motte, Damien, et al.
(författare)
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Evaluation of a method supporting the integration of packaging development into product development using an assessment framework for methodologies under development
- 2018
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Ingår i: Proceedings of the 12th International Symposium on Tools and Methods of Competitive Engineering - TMCE'18. - 9789461869104 ; , s. 471-486
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Konferensbidrag (refereegranskat)abstract
- This paper presents the evaluation of a method supporting the integration of packaging development into product development through the use of an assessment framework for methodologies under development. While the evaluation of the integration method itself is critical for its further development the main objective is to use this evaluation as a further testing of the assessment framework. The assessment framework has only been tested once in its current version and replications are needed. The results of the testing of the support method indicate that it has high consistency but should be further developed with regards to simplicity of use, and overall attractiveness. About the framework, only minor changes were needed to assess the support method. The testing also shows that the framework can also be used for the assessment of methods, not only methodologies.
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| 8. |
- Motte, Damien, et al.
(författare)
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Integration of the computer-based design analysis activity in the engineering design process - A literature survey
- 2014
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Ingår i: Proceedings of the 10th International Symposium on Tools and Methods of Competitive Engineering - TMCE'14. - Delft : Delft University of Technology. - 9789461861771 - 9461861761 - 9789461861764 ; 2, s. 1181-1194
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Konferensbidrag (refereegranskat)abstract
- Computer-based design analysis is nowadays a common activity in most development projects. Used for design evaluation, verification, validation, or as a support for design exploration, it fulfils an important support function for the engineering designer, thus making it essential to have an operationally efficient and effective integration between both the engineering design and design analysis activities in the overall development project. In this area, most works are focusing on software (mainly CAD/CAE) integra-tion, but not on the integration between computer-based design analysis and engineering design at the process level or on the collaboration between the engineering designer and the design analyst. This paper presents a review of the literature on that specific topic, namely the integration of the computer-based design analysis activity in the engineering design process. Different research topics are identified and elaborated upon: integration in general process models; rec-ommendations for the different analysis steps; analysis early in the engineering design process; integration of design analysis in the engineering designer's work; alternative usages of design analysis in the engineering design process; and others, such as recommending guidelines instead of process models, quality assurance aspects, education, and implementation issues. Some neglected aspects were also identified. Among others, there is a lack of research into the so-called technology development (development of design analysis procedures and guidelines), and a need for emphasis on uncertainties, both coupled with the design analysis activity.
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| 9. |
- Motte, Damien, et al.
(författare)
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The cognitive aspects of the engineering design activity – A literature survey
- 2004
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Ingår i: Proceedings of the 5th International Symposium on Tools and Methods of Competitive Engineering - TMCE'04. - 90 5966 018 8 ; 2, s. 1095-1096
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Konferensbidrag (refereegranskat)abstract
- This literature survey aims at representing the current research on the cognitive aspects of the design activity, with an emphasis on problem-solving processes. The study is based on the selection of about sixty papers and books on the subject. The principal parameters of the study were defined as follows: general topics of the works, objects of the works, cognitive approaches, research results, study methods. The findings from this survey are: Most of the studies concern design theory, and then design support and education; They focus mainly on the conceptual design phase; The foremost cognitive aspect studied is problem solving, but knowledge, imagery and memory are also considered; The results of the reviewed papers confirm the validity of prescriptive methods for the design process, but there is a felt need for acknowledgement of the design activity constraints induced by cognitive limitations; The methods employed in most experiments are based on verbal protocol analysis and sketch analysis. The most important findings of this survey are that research should be extended to new areas, such as: Research on the cognitive aspects of the designer in the embodiment and detail design phases; Implementation of the research findings in current design practice, to improve the design process; Research of the origins of expert knowledge.
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| 10. |
- Noc, Marko, et al.
(författare)
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A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction : The COOL AMI EU Pivotal Trial
- 2021
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Ingår i: EuroIntervention. - 1774-024X. ; 17:6, s. 466-473
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite primary PCI (PPCI), ST-elevation myocardial infarction (STEMI) can still result in large infarct size (IS). New technology with rapid intravascular cooling showed positive signals for reduction in IS in anterior STEMI. Aims: We investigated the effectiveness and safety of rapid systemic intravascular hypothermia as an adjunct to PPCI in conscious patients, with anterior STEMI, without cardiac arrest. Methods: Hypothermia was induced using the ZOLL® Proteus™ intravascular cooling system. After randomisation of 111 patients, 58 to hypothermia and 53 to control groups, the study was prematurely discontinued by the sponsor due to inconsistent patient logistics between the groups resulting in significantly longer total ischaemic delay in the hypothermia group (232 vs 188 minutes; p<0.001). Results: There were no differences in angiographic features and PPCI result between the groups. Intravascular temperature at wire crossing was 33.3+0.9°C. Infarct size/left ventricular (IS/LV) mass by cardiac magnetic resonance (CMR) at day 4-6 was 21.3% in the hypothermia group and 20.0% in the control group (p=0.540). Major adverse cardiac events at 30 days increased non-significantly in the hypothermia group (8.6% vs 1.9%; p=0.117) while cardiogenic shock (10.3% vs 0%; p=0.028) and paroxysmal atrial fibrillation (43.1% vs 3.8%; p<0.001) were significantly more frequent in the hypothermia group. Conclusions: The ZOLL Proteus intravascular cooling system reduced temperature to 33.3°C before PPCI in patients with anterior STEMI. Due to inconsistent patient logistics between the groups, this hypothermia protocol resulted in a longer ischaemic delay, did not reduce IS/LV mass and was associated with increased adverse events.
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| 11. |
- Stridh, Bengt, Universitetslektor, 1957-, et al.
(författare)
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Uncertainties in Yield Assessments and PV LCOE : Report IEA-PVPS T13-18:2020 November 2020
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Yield assessments (YA) and Long-Term Yield Predictions (LTYP) are a prerequisite for business decisions on long term investments into photovoltaic (PV) power plants. Together with cost data (CAPEX, OPEX and discount rate), the output of a YA and LTYP (utilisation rate, performance loss rate and lifetime) provides to the financial investors the parameters needed for the calculation of the Levelised Cost of Electricity (LCOE) and to assess the cash flow model of an investment with relative Internal Rate of Return (IRR) and Net Present Value (NPV).YA and LTYP outputs should be provided with a related exceedance probability. This gives the right tool to stakeholders involved in PV projects to take the best decision in terms of riskaversion. A reduction in the uncertainty of the energy yield can lead to higher values for a given exceedance probability and hence a stronger business case. Various efforts in the literature show the importance of having a common framework that can assess the impact of technical risks on the economic performance of a PV project.The most important parameter influencing the energy yield assessment is the site-specific insolation. Several aspects need to be considered: reliability of the database, interannual variability, long term trends.Site adaptation techniques combine short-term measured data and long-term satellite estimates. Short periods of measured data but with site-specific seasonal and diurnal characteristics are combined with satellite-derived data having a long period of record with not necessarily site-specific characteristics. Upon completion of the measurement campaign, which is typically around one-year, different methodologies can be applied between the measured data at the target site, spanning a relatively short period, and the satellite data, spanning a much longer period. The complete record of satellite data is then used in this relationship to predict the long-term solar resource at the target site. Assuming a strong correlation, the strengths of both data sets are captured and the uncertainty in the long-term estimate can be reduced. In Müller et al [1] an analysis on long-term trends for measured in-plane irradiance, Performance Ratio and energy yield for 44 rooftop installations in Germany was performed showing an average increase of in-plane irradiance of 1.1 %/year or about 11 %/decade over the period 2008 to 2018 for these systems. The increase in irradiance was especially higher than the observed Performance Loss Rate so that the energy yields of the systems analysed increased over the years with an average trend of 0.3 %/year. The typical output of Yield Assessments should report the contribution to each derating factor, starting from the Global Horizontal Irradiation to the energy injected in the grid. The starting point of PR = 100 is considered after applying the horizon shading as this become the annual insolation seen by the PV modules. The following table shows a best practice in providing an overview of gains/losses along each modelling step and the related uncertainty. The uncertainty related to each modelling step can be provided already referred to the irradiation/yield value or to the parameter that is modelled. The value in the table for the specific yield (including its uncertainty) is to be understood as an average value over the entire operating period. The possible deviations between the yields for individual recorded years and the specific yield calculated can be assessed by including interannual variability. For example, for temperature-dependent losses, the value of uncertainty could be referred to the temperature variability of the profile used in the assessment or to the temperature model used in the assessment. The ambient temperature variability and the various temperature models will lead to a different contribution in terms of yield loss and in terms of uncertainty.An emerging challenge in YAs is also due to the deployment of novel technologies (e.g. bifacial PV modules) with a contribution in terms of uncertainty that needs to be properly assessed.Building upon the knowledge available in the literature and the previous IEA PVPS Task 13 report [2], in this report we have moved forward from the uncertainty framework in yield assessment to two real implementations of it and the impact that uncertainties can have on lifetime yield predictions, on the LCOE and on the cash-flow.One of the most relevant question that we have tried to answer is also the following: How reliable are YA’s?This is an apparently simple question; however, the answer is not equally simple. Typically, investors require one YA. In some cases, more YAs might be requested if results are unclear. The various YAs can be averaged to assign a purchase value to a given project. In any case the question remains unanswered: why different assessors obtain different answers? Is one YA more reliable than others?
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