| 1. |
- Deng, Min, et al.
(författare)
-
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
-
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
-
Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
|
|
| 2. |
- Zhou, Panpan, et al.
(författare)
-
Adaptive output observer for a nonautonomous leader system over periodic switching topologies and its applications to the formation control of offshore vessels
- 2023
-
Ingår i: International Journal of Robust and Nonlinear Control. - : Wiley. - 1049-8923 .- 1099-1239. ; 33:15, s. 9433-9449
-
Tidskriftsartikel (refereegranskat)abstract
- This paper proposes an adaptive observer for an active leader and designed a distributed observer-based control law for the formation control of networked uncertain offshore vessels under the switching topologies. The design of the observer, only depending on the output of the leader system, is featured with the ability of accurately estimating the output of the leader system with an unknown input over the time-varying communication network, satisfying the periodic switching condition. Then based on the output-based observer, the formation problem of multiple offshore vessels is converted into the stabilization problem of a multi-input multi-output augmented system by further combining the internal model technique and performing a coordinate and input transformation. The original problem is finally solved through constructing a stabilizer for the time-varying uncertain augmented system, and the efficiency of our design is validated by the formation control of a group of offshore vessels.
|
|
| 3. |
- Zhou, Panpan, et al.
(författare)
-
Distributed Strategies for Pursuit-Evasion of High-Order Integrators
- 2024
-
Ingår i: 2024 IEEE 18th International Conference on Control and Automation, ICCA 2024. - : IEEE Computer Society. ; , s. 810-814
-
Konferensbidrag (refereegranskat)abstract
- This paper presents decentralized solutions for addressing pursuit-evasion problems involving high-order in-tegrators with intracoalition cooperation and intercoalition confrontation. To ensure that the control strategies indepen-dent of the relative velocities, accelerations and higher order information of neighbors, we introduce distinct error vari-ables and hyper-variables. Consequently, this approach only requires agents to exchange position information or measure the relative positions of neighbors. The distributed strategies reflect the goals of intracoalition cooperation or intercoalition confrontation of the players. Additionally, we present the conditions for capture and formation control with exponential convergence for three cases: one-pursuer-one-evader, multiple-pursuer-one-evader, and multiple- pursuer- multiple-evader. The results show that the conditions depend on the structure of the communication graph, the weights in the control law, and the expected formation configuration. Finally, the effectiveness of the proposed algorithm is demonstrated through simulation results.
|
|
