| 1. |
- Abgrall, N., et al.
(författare)
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The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)
- 2017
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Ingår i: AIP Conference Proceedings. - : Author(s). - 1551-7616 .- 0094-243X. ; 1894
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Konferensbidrag (refereegranskat)abstract
- The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ∼0.1 count /(FWHM·t·yr) in the region of the signal. The current generation 76Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale 76Ge experiment. The collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 1028 years, using existing resources as appropriate to expedite physics results.
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| 2. |
- Pham, M. K., et al.
(författare)
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A new reference material for radionuclides in the mussel sample from the Mediterranean Sea (IAEA-437)
- 2010
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 283:3, s. 851-859
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Tidskriftsartikel (refereegranskat)abstract
- A new Reference Material (RM) for radionuclides in mussel (Mytilus galloprovincialis) from the Mediterranean Sea (IAEA-437) is described and the results of the certification process are presented. Four radionuclides (K-40, U-234, U-238, and Pu239+240) have been certified, and information values on massic activities with 95% confidence intervals are given for nine radionuclides (Cs-137, Pb-210(Po-210), Ra-226, Ra-228, Th-228, Th-230, Th-232, U-235, and Am-241). Results for less frequently reported radionuclides (Sr-90, I-129, Pu-238, Pu-239, and Pu-240) are also reported. The RM can be used for quality assurance/quality control of the analysis of radionuclides in mussel samples, for the development and validation of analytical methods and for training purposes. The material is available in 200 g units.
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| 3. |
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| 4. |
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| 5. |
- Malmstrom, E, et al.
(författare)
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Dendritic polymers for photonic applications.
- 2002
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Ingår i: Abstracts of Papers of the American Chemical Society. - 0065-7727. ; 224, s. 384-POLY-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Merino, E. G., et al.
(författare)
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Molecular dynamics of poly(ATRIF) homopolymer and poly(AN-co-ATRIF) copolymer investigated by dielectric relaxation spectroscopy
- 2011
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Ingår i: European Polymer Journal. - : Elsevier BV. - 0014-3057 .- 1873-1945. ; 47:7, s. 1429-1446
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Tidskriftsartikel (refereegranskat)abstract
- Aiming to develop new dielectric polymers containing CN and F groups with strong dipole moments, a novel copolymer of acrylonitrile (AN) and 2,2,2-trifluoroethyl acrylate (ATRIF) was synthesized in acetonitrile by free radical process as well as the respective homopolymer (poly(ATRIF)). The copolymer's composition and microstructure were analyzed by FTIR, (1)H and (13)C NMR spectroscopy and SEC. The molar incorporation of AN determined in the copolymer by NMR was 58 mol%. Thermogravimetric analysis of poly(AN-co-ATRIF) copolymer showed good thermal stability comparatively to the fluorinated homopolymer. Both copolymer, poly(AN-co-ATRIF), and homopolymer, poly(ATRIF), were dielectrically characterized over a frequency range from 10(-1) to 10(6) Hz, and in a temperature range from 223 to 393 K. The dominating relaxation process detected in both materials is the alpha-relaxation, associated with the dynamic glass transition. A VFTH temperature dependence of the relaxation times (tau) was found for both materials, as characteristic of cooperative processes, from which the respective glass transition temperatures (T(g)(tau = 100 s)) were estimated, which differ similar to 40 K, the one of the copolymer being higher (307 K) in accordance to the calorimetric analysis. This effect was attributed to a higher stiffness of the backbone in the copolymer originated by the inclusion of the acrylonitrile groups. Both relaxation functions have the same breath of relaxation times allowing constructing a single master curve, indicating similar non-exponential character. A less fragile behavior was found for the copolymer. This was rationalized in a more straightforward way by the free volume approach instead from a correlation between fragility and intermolecular coupling. It was found that in the copolymer the free volume increases at a lower rate with the temperature increase. It was inferred from the VFTH temperature dependence of the dc conductivity and low values of the decoupling index that ion motion is significantly influenced by the dynamics of the alpha-process.
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| 7. |
- Ou, Wanyu Amy, et al.
(författare)
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Towards a translingual conceptualization of language policy for EMI universities
- 2021
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Ingår i: Annual Conference of American Association for Applied Linguistics (AAAL).
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This study is conducted against the background that universities around the world have been increasingly presented themselves to be international through according to space for English in their language policies (Doiz, Lasagabaster, & Sierra, 2012), and a widespread belief has been generated that internationalization of higher education means internationalization in English (e.g., Hadley, 2014; Phillipson, 2006). Our article, based on the multilingual/translingual realities, provides a critical review of the role that English has been playing in modern internationalized universities, especially the EMI universities, and accordingly, proposes an expanded view of lingua franca in EMI university contexts in terms of translingualism (Canagarajah, 2018; Li, 2018) to better situate English together with other co-existing resources for people to communicate. To illustrate how translingual practice functions as a lingua franca for international communication among multilingual students with different linguistic backgrounds, we draw upon the ethnographical data (participant observation, field notes, interviews, language portraits, policy documents, texts and photos) collected during a period of 20 months at an EMI transnational university in China. Employing nexus analysis (Hult, 2015) in concert with a multimodal biographic discourse analysis (Busch, 2012), we present the complex and multidimensional nature of lingua franca communication, drawing attention to its connection with and influence on individuals’ repertoire development, real-life communication conventions and university language policy. The findings of our study contribute to a discussion of EMI university language and internationalization policy making that focuses on providing institutional recognition and support for cultivating the existing linguistic resources among the student body and creating space for multilingual students to draw upon the full range of semiotic and spatial resources to achieve successful lingua franca communication and to develop personal repertoires.
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| 8. |
- Persson, L., et al.
(författare)
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Separation of mass-overlapped time of flight-energy elastic recoil detection analysis data using Ryan and Jamieson's dynamic analysis method
- 2001
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - 0168-583X .- 1872-9584. ; 179:3, s. 403-411
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Tidskriftsartikel (refereegranskat)abstract
- Time of flight-energy (ToF-E) elastic recoil detection analysis (ERDA) data often contains mass signals with considerable overlap from adjacent isotopes in the mass-energy plane. An evaluation has been carried out of the suitability of the dynamic analysis method proposed by Ryan and Jamieson to decompose elemental signals with overlapping mass. This method is shown to work very well on generated test data and the result when it was applied to experimental data appears quite promising. Very accurate mass calibration and lineshape determination was found to be a prerequisite for the application of the method.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- HOLMQUIST, M, et al.
(författare)
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TRP89 IN THE LID OF HUMICOLA-LANUGINOSA LIPASE IS IMPORTANT FOR EFFICIENT HYDROLYSIS OF TRIBUTYRIN
- 1994
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Ingår i: Lipids. - : Wiley. - 0024-4201 .- 1558-9307. ; 29:9, s. 599-603
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Tidskriftsartikel (refereegranskat)abstract
- To determine whether Trp89 located in the lid of the lipase (EC 3.1.1.3) from Humicola lanuginosa is important for the catalytic property of the enzyme, site-directed mutagenesis at Trp89 was carried out. The kinetic properties of wild type and mutated enzymes were studied with tributyrin as substrate. Lipase variants in which Trp89 was changed to Phe, Leu, Gly or Glu all showed less than 14% of the activity compared to that of the wild type lipase. The Trp89Glu mutant was the least active with only 1% of the activity seen with the wild type enzyme. Ah Trp mutants had the same binding affinity to the tributyrin substrate interface as did the wild type enzyme. Wild type lipase showed saturation kinetics against tributyrin when activities were measured with mixed emulsions containing different proportions of tributyrin and the nonionic alkyl polyoxyethylene ether surfactant, Triton DF-16. Wild type enzyme showed a V-max = 6000 +/- 300 mmol.min(-1).g(-1) and an apparent K-m = 16 +/- 2% (vol/vol) for tributyrin in Triton DF-16, while the mutants did not show saturation kinetics in an identical assay. The apparent K-m for tributyrin in Triton DF-16 was increased as the result of replacing Trp89 with other residues (Phe, Leu, Gly or Glu). The activities of all mutants were more sensitive to the presence of Triton DF-16 in the tributyrin substrate than was wild type lipase. The activity of the Trp89Glu mutant was decreased to 50% in the presence of 2 vol% Triton DF-16 compared to the activity seen with pure tributyrin as substrate. Wild type lipase and all mutants except Trp89Glu had the same affinity for the substrate interface formed by 15.6 vol% tributyrin in Triton DF-16. The Trp89Glu mutant showed a lower affinity than all the other lipase variants for the interface of 15.6 vol% tributyrin in Triton DF-16. The study showed that Trp89 located in the lid of H. lanuginosa lipase is important for the efficient hydrolysis of tributyrin and that this residue plays a role in the catalytic steps after adsorption of the lipase to the substrate interface.
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| 14. |
- Hult, G. Tomas M., et al.
(författare)
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A Ten Country-Company Study of Sustainability and Product-Market Performance : Influences of Doing Good, Warm Glow, and Price Fairness
- 2018
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Ingår i: Journal of Macromarketing. - : Sage Publications. - 0276-1467 .- 1552-6534. ; 38:3, s. 242-261
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Tidskriftsartikel (refereegranskat)abstract
- Countries, companies, and customers are becoming increasingly concerned with sustainability. However, it is unclear how much increased cost, if any, companies are willing to tolerate for sustainability efforts at the rate of potentially lower profits. Plus, what are the customers' sensitivities to the prices of products/services that are developed within the realm of sustainability initiatives (e.g., how much more can the products/services cost and still be viable)? Additionally, with 193 countries of the United Nations ratifying the Sustainable Development Goals, we know that countries are focused on sustainability, but can companies achieve positive sustainability effects on performance above what countries are doing? Consequently, what are the macro-micro dynamics in play for sustainability efforts? In a 10-country study involving 4,051 companies, we examine these macro-micro (country-company) dynamics, company costs, customer costs, and price sensitivities on the effects of sustainability on companies' performance. The results indicate that positive effects on companies' performance can be achieved (1) from the companies' sustainability efforts in all 10 countries studied, (2) even if the costs and/or prices increased by 27 to 72 percent (depending on the dynamic and scenario), and (3) by companies implementing sustainability efforts that are 5 to 30 percent above the efforts of the country. Increased sustainability effects can also be gained from lowering customer and company costs, but no such effects were found when lowering product prices.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- JOHANSSON, M, et al.
(författare)
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SYNTHESIS, CHARACTERIZATION, AND CURING OF WELL-DEFINED ALLYL ETHER-MALEATE FUNCTIONAL ESTER OLIGOMERS - LINEAR VERSUS NONLINEAR STRUCTURES
- 1992
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Ingår i: Journal of Polymer Science Part A. - : Wiley. - 0887-624X .- 1099-0518. ; 30, s. 2203-2210
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Tidskriftsartikel (refereegranskat)abstract
- A series of allyl ether-maleate functional star-shaped esters with from one to four arms has been synthesized. The structures that have been made are an analogous series with increasing molecular weight and functionality where the increase in molecular weight has been made nonlinear, i.e., star-shaped. The resins are monodisperse in the sense that each arm has a well-defined structure and that, within a certain sample, only one type of molecule exists. The viscosity and rheological behavior of the resins have been studied. The curing kinetics of the star-shaped (branched) resins and the properties of the films formed have also been studied. These properties have been related to differences in functionality and to differences in the molecular architecture of the resins.
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| 20. |
- Joseph, Abigail, et al.
(författare)
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ABO Genotyping finds more A2 to B kidney transplant opportunities than lectin-based subtyping
- 2023
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135. ; 23:4, s. 512-519
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Tidskriftsartikel (refereegranskat)abstract
- ABO compatibility is important for kidney transplantation, with longer waitlist times for blood group B kidney transplant candidates. However, kidneys from non-A1 (eg, A2) subtype donors, which express less A antigen, can be safely transplanted into group B recipients. ABO subtyping is routinely performed using anti-A1 lectin, but DNA-based genotyping is also possible. Here, we compare lectin and genotyping testing. Lectin and genotype subtyping was performed on 554 group A deceased donor samples at 2 transplant laboratories. The findings were supported by 2 additional data sets of 210 group A living kidney donors and 124 samples with unclear lectin testing sent to a reference laboratory. In deceased donors, genotyping found 65% more A2 donors than lectin testing, most with weak lectin reactivity, a finding supported in living donors and samples sent for reference testing. DNA sequencing and flow cytometry showed that the discordances were because of several factors, including transfusion, small variability in A antigen levels, and rare ABO∗A2.06 and ABO∗A2.16 sequences. Although lectin testing is the current standard for transplantation subtyping, genotyping is accurate and could increase A2 kidney transplant opportunities for group B candidates, a difference that should reduce group B wait times and improve transplant equity.
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| 21. |
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| 22. |
- Lindberg, Christopher, et al.
(författare)
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Search for Pompe disease among patients with undetermined myopathies
- 2016
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 133:2, s. 131-135
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Tidskriftsartikel (refereegranskat)abstract
- Objective - Pompe disease is a rare treatable glycogen storage disease with in adults - a limb-girdle muscle weakness. Muscle biopsy may fail to show the typical vacuolar myopathy. We asked if we had undiagnosed patients with Pompe disease in western Sweden. Material and Methods - We searched the muscle biopsy registry during the time period 1986 until 2006 including 3665 biopsies and included patients at our Neuromuscular Center with unspecified myopathy or limb-girdle muscular dystrophy. The dry blood spot test was used to identify patients with Pompe disease. Results - A total of 82 patients (46 from the biopsy register and 36 from our center) were seen and dry blood spot test was obtained. No patient with Pompe disease was found. The dry blood spot test was low in three cases (11, 16, and 18% of normal) but a second blood sample showed a normal result based on GAA enzyme activity in lymphocytes in all three patients. In one patient with low normal result of the analysis in lymphocytes a genetic test showed no pathogenic mutations. Further investigation gave a definite diagnose of another myopathy in 12 patients. Conclusions - The prevalence of Pompe disease in western Sweden (3 in 1.27 million or 0.24 per 100.000 inhabitants) is lower than in the Netherlands and New York. Re-evaluation of patients with myopathies but without definite diagnosis is rewarding since 12 of 82 patients in our study had a definite molecular diagnosis after workup.
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| 23. |
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| 24. |
- MARTINELLE, M, et al.
(författare)
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ON THE INTERFACIAL ACTIVATION OF CANDIDA-ANTARCTICA LIPASE-A AND LIPASE-B AS COMPARED WITH HUMICOLA-LANUGINOSA LIPASE
- 1995
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Ingår i: BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM. - ROYAL INST TECHNOL,DEPT BIOCHEM & BIOTECHNOL,S-10044 STOCKHOLM,SWEDEN. : ELSEVIER SCIENCE BV. - 0005-2760. ; 1258:3, s. 272-276
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Tidskriftsartikel (refereegranskat)abstract
- The interfacial activation of Candida antarctica lipase A (CALA) and B (CALB) has been investigated and compared with that of Humicola lanuginosa lipase (HLL). CALB displayed no interfacial activation towards p-nitrophenyl butyrate (PNPB) when exceeding the solubility limit of the substrate. No activation was observed towards p-nitrophenyl acetate (PNPA) at the addition of sodium dodecyl sulfate (SDS) nor in the presence of a solid polystyrene surface. The catalytic action of CALB was very different from that of Humicola lanuginosa lipase, which showed a pronounced interfacial activation with the same substrates. The basis for the anomalous behaviour of CALB is proposed to be due to the absence of a lid that regulates the access to the active site. in contrast to CALB, CALA expressed interfacial activation, but the activation was not as prominent as for Humicola lanuginosa lipase (HLL). The structural basis for the activation of CALA is unknown.
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| 25. |
- Martinelle, M, et al.
(författare)
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The role of Glu87 and Trp89 in the lid of Humicola lanuginosa lipase
- 1996
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Ingår i: Protein Engineering. - : Oxford University Press (OUP). - 0269-2139 .- 1460-213X. ; 9:6, s. 519-524
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Tidskriftsartikel (refereegranskat)abstract
- The importance of Glu87 and TRp89 in the lid of Humicola lanuginosa lipase for the hydrolytic activity at the water/lipid interface was investigated by site-directed mutagenesis. It was found that the effect on the hydrolytic activity upon the replacement of Trp89 with Phe, Leu, Gly or Glu was substrate dependent, The Trp89 mutants displayed an altered chain length specificity towards triglycerides, with a higher relative activity towards triacetin and trioctanoin compared with tributyrin, Trp89 was shown to be less important in the hydrolysis of vinyl esters compared with ethyl esters and triglycerides. An exclusive effect on the acylation reaction rate by the mutation of Trp89 was consistent with the data, It is suggested that Trp89 is important in the process of binding the acyl chain of the substrate into the active site for optimal acylation reaction rate, The Trp89Phe mutation resulted in an increased hydrolytic activity towards 2-alkylalkanoic acid esters. This is suggested to be due to reduction of unfavourable van der Waals contacts between Trp89 and the 2-substituent of the substrate, Thus, in contrast to natural substrates, Trp89 has a negative impact on the catalytic efficiency when substrates with bulky acyl chains are used, In contrast to the Trp89 mutations, the effect on the hydrolytic activity of the Glu87Ala mutation was almost substrate independent, 35-70% activity of wild-type lipase, A reduction of both the acylation and deacylation reaction was consistent with the data.
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| 26. |
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| 27. |
- Olsson, Emelie, 1993, et al.
(författare)
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An experimental and theoretical characterization of the electronic structure of doubly ionised disulfur
- 2022
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Using time-of-flight multiple electron and ion coincidence techniques in combination with a helium gas discharge lamp and synchrotron radiation, the double ionisation spectrum of disulfur (S-2) and the subsequent fragmentation dynamics of its dication are investigated. The S-2 sample was produced by heating mercury sulfide (HgS), whose vapour at a suitably chosen temperature consists primarily of two constituents: S-2 and atomic Hg. A multi-particle-coincidence technique is thus particularly useful for retrieving spectra of S-2 from ionisation of the mixed vapour. The results obtained are compared with detailed calculations of the electronic structure and potential energy curves of S-2(2+) which are also presented. These computations are carried out using configuration interaction methodology. The experimental results are interpreted with and strongly supported by the computational results.
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| 28. |
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| 29. |
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| 30. |
- Rotticci-Mulder, J. C., et al.
(författare)
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Expression in Pichia pastoris of Candida antarctica lipase B and lipase B fused to a cellulose-binding domain
- 2001
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Ingår i: Protein Expression and Purification. - : Elsevier BV. - 1046-5928 .- 1096-0279. ; 21:3, s. 386-392
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Tidskriftsartikel (refereegranskat)abstract
- Candida antarctica lipase B (CALB) and C. antarctica lipase B fused to a cellulose-binding domain (CBD-CALB) were expressed functionally in the methylotrophic yeast Pichia pastoris. The cellulose-binding domain originates from cellulase A of the anaerobic rumen fungus Neocallimastix patriciarum. The genes were fused to the a-factor secretion signal sequence of Saccharomyces cerevisiae and placed under the control of the alcohol oxidase gene (AOX1) promoter. The recombinant proteins were secreted into the culture medium reaching levels of approximately 25 mg/L. The proteins were purified using hydrophobic interaction chromatography and gel filtration with an overall yield of 69%. Results from endoglycosidase H digestion of the proteins showed that CALB and CBD-CALB were N-glycosylated. The specific hydrolytic activities of recombinant CALB and CBD-CALB were identical to that reported for CALB isolated from its native source. The fusion of the CBD to the lipase resulted in a greatly enhanced binding toward cellulose for CBD-CALB compared with that for CALB.
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| 31. |
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| 32. |
- Trollsas, M, et al.
(författare)
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Highly branched radial block copolymers via dendritic initiation of aliphatic polyesters
- 1998
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Ingår i: Journal of Polymer Science Part A. - 0887-624X .- 1099-0518. ; 36, s. 2793-2798
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Tidskriftsartikel (refereegranskat)abstract
- Living ring opening polymerization of epsilon-caprolactone initiated from the numerous chain-end hydroxymethyl groups of the analogous dendrimeric and hyperbranched polyesters derived from 2,2-bis(hydroxymethyl) propionic acid is described. By controlling the size of the dendritic macromolecule and the molar ratio of epsilon-caprolactone, a variety of highly branched radial block copolymers are obtained. Comparison of the results obtained for the dendrimeric and hyperbranched initiators demonstrates that the reactivity of the chain-end hydroxymethyl groups in the dendrimer are significantly greater than in the isomeric hyperbranched case. (C) 1998 John Wiley & Sons, Inc.
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| 33. |
- Trollsås, M., et al.
(författare)
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The influence of the molecular structure on the second-order nonlinear optical properties of pyroelectric liquid crystalline polymers
- 1998
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Ingår i: American Chemical Society Symposium Series (ACS). - Washington, DC : American Chemical Society. - 0097-6156 .- 1947-5918. ; 695, s. 315-327
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Tidskriftsartikel (refereegranskat)abstract
- Pyroelectric Liquid Crystal Polymers (PLCP), a novel class of material with intrinsic polar order developed in our laboratory, are discussed. Thin films (2-4µm) of PLCP were prepared by photopolymerization of ferroelectric liquid crystalline monomers in the chiral smectic C (SmC*) phase. The poly(acrylate) materials have been structurally modified in order to improve their nonlinear optical and thermal properties. Further are their longterm nonlinear optical properties discussed based on results from second harmonic generation (SHG), spontaneous polarization (Ps), and dielectric spectroscopy.
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| 34. |
- Vallo Hult, Helena, 1976-, et al.
(författare)
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Egenmonitorering : evidenskartläggning genom sammanställning av systematiska översikter för utvalda diagnosgrupper
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundIn Region Västra Götaland (VGR), the development of remote patient monitoring is given high priority, aiming for improvements for patients and reduction of healthcare costs. In this report we defined remote patient monitoring as continuous follow-up of relevant health-related parameters of patients located outside healthcare facilities (e.g. at home). Measurements taken by analogue or digital devices, objective and/or subjective assessments, are delivered digitally to the patient and to a healthcare professional. The healthcare professional provides the patient with feedback on the reported data (feedback may be automatically generated if data are within a predefined range). The plan in VGR is to introduce remote monitoring in selected diagnosis groups – some of which already started using remote monitoring.AimThe aim of this report was to provide an overview of systematic reviews regarding remote monitoring(as add on or replacement of visits in current standard of care) compared to standard of care in 25 selected diagnosis groups.MethodIn order to clarify how remote monitoring is intended to be used in the 25 diagnosis groups, representatives from the respective clinical areas were interviewed. As the scope of this project covered many diagnosis groups, the search was limited to systematic reviews (SRs) of randomised (RCTs) or non-randomised clinical trials. The relevance of each identified SR for our PICO(Population, Intervention, Comparator and Outcomes) was assessed by at least two project members (one clinical representative and one from HTA-centrum). Relevant SRs were assessed by at least two project members using SNABBSTAR, a tool developed by The Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) for assessment of risk of bias/systematic errors in SRs. The tool consists of six steps and assessment of an SR is stopped as soon as the criteria for a specific level are not met.The steps are: 1. Definition of PICO and literature search; 2. Inclusion/exclusion according to PICO, listing of included studies; 3. Risk of bias assessments; 4. Evidence synthesis/meta-analyses; 5. Certainty of evidence consideration; 6. Documentation of excluded studies, conflicts of interest, and an a priori published SR protocol.SNABBSTAR evaluates how useful an SR is by assessing the methodology used in the SR. In the current project, SRs reaching at least SNABBSTAR level 4 were considered to provide relevant data synthesis. As reaching SNABBSTAR level 5 or 6 is considered necessary for reliable conclusions, we cited key conclusions only from SRs reaching these levels. We did not extract any data from the included SRs.ResultsThe literature search resulted in 3,332 hits. Of these, 279 were read in full text to assess their relevance for the PICO. Seventy-five SRs were considered relevant and were included; these were assessed by SNABBSTAR.
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| 35. |
- Arriaza Hult, Maria, 1990-
(författare)
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Party Education as Mobilisation : Framing education in Swedish and Spanish political parties of the left
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation aims to contribute knowledge of how five movement-related left parties in Sweden and Spain formulate education for their members. By analysing (i) the Swedish Social Democratic Workers’ Party, (ii) the Swedish Left Party, (iii) the Spanish Social Democratic Workers’ Party, (iv) the Spanish United Left and (v) the Spanish Podemos, the study interprets how organised educational activities are formulated and motivated with the aim to instigate member engagement. The analysis builds on interviews with leading party representatives and study leaders, study and course materials, and other official documents, which steer how the parties organise their education. With a framing perspective as a theoretical itinerary, the study emphasises parties' education as a setting where meaning is formulated to initiate collective action. The four included papers stress and discuss how educational material is formulated and how the parties perceive and motivate organised party education. Papers 1 and 2 analyse text materials and shows how educational materials establish narratives that invites the members to become active in the parties. Even though the educational narrative is welcoming, the study materials also reinforce frames of how to be schooled into becoming an ideal party member. Papers 3 and 4 study interview materials and suggest that member education is interpreted as something that strengthens parties’ movement relations, provides useful training, opens up a space for political reflection, and constructs a feeling of community within the parties. The dissertation emphasises that these five movement-related left parties perceive their educational activities as settings that create relations between the party and its members. Applying the framing perspective to the understudied educational practices that transpire in parties contributes to deepening the theoretical understanding of how education can be formulated in relation to its bearing on creating collective identities.
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| 36. |
- Assefa, Getachew, et al.
(författare)
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Environmental assessment of building properties — Where natural and social sciences meet : the case of EcoEffect
- 2007
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323 .- 1873-684X. ; 42:3, s. 1458-1464
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Tidskriftsartikel (refereegranskat)abstract
- The EcoEffect method of assessing external and internal impacts of building properties is briefly described. The external impacts of manufacturing and transport of the building materials, the generation of power and heat consumed during the operation phase are assessed using life-cycle methodology. Emissions and waste; natural resource depletion and toxic substances in building materials are accounted for. Here methodologies from natural sciences are employed. The internal impacts involve the assessment of the risk for discomfort and ill-being due to features and properties of both the indoor environment and outdoor environment within the boundary of the building properties. This risk is calculated based on data and information from questionnaires; measurements and inspection where methodologies mainly from social sciences are used. Life-cycle costs covering investment and utilities costs as well as maintenance costs summed up over the lifetime of the building are also calculated.The result presentation offers extensive layers of diagrams and data tables ranging from an aggregated diagram of environmental efficiency to quantitative indicators of different aspects and factors. Environmental efficiency provides a relative measure of the internal quality of a building property in relation to its external impact vis-à-vis its performance relative to other building properties.
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| 37. |
- Barjesteh van Waalwijk van Doorn-Khosrovani, Sahar, et al.
(författare)
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PCM4EU and PRIME-ROSE : Collaboration for implementation of precision cancer medicine in Europe
- 2024
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Ingår i: Acta Oncologica. - 1651-226X .- 1651-226X. ; 63, s. 385-391
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In the two European Union (EU)-funded projects, PCM4EU (Personalized Cancer Medicine for all EU citizens) and PRIME-ROSE (Precision Cancer Medicine Repurposing System Using Pragmatic Clinical Trials), we aim to facilitate implementation of precision cancer medicine (PCM) in Europe by leveraging the experience from ongoing national initiatives that have already been particularly successful. PATIENTS AND METHODS: PCM4EU and PRIME-ROSE gather 17 and 24 partners, respectively, from 19 European countries. The projects are based on a network of Drug Rediscovery Protocol (DRUP)-like clinical trials that are currently ongoing or soon to start in 11 different countries, and with more trials expected to be established soon. The main aims of both the projects are to improve implementation pathways from molecular diagnostics to treatment, and reimbursement of diagnostics and tumour-tailored therapies to provide examples of best practices for PCM in Europe. RESULTS: PCM4EU and PRIME-ROSE were launched in January and July 2023, respectively. Educational materials, including a podcast series, are already available from the PCM4EU website (http://www.pcm4eu.eu). The first reports, including an overview of requirements for the reimbursement systems in participating countries and a guide on patient involvement, are expected to be published in 2024. CONCLUSION: European collaboration can facilitate the implementation of PCM and thereby provide affordable and equitable access to precision diagnostics and matched therapies for more patients. ble from the PCM4EU website (http://www.pcm4eu.eu). The first reports, including an overview of requirements for the reimbursement systems in participating countries and a guide on patient involvement, are expected to be published in 2024. CONCLUSION: European collaboration can facilitate the implementation of PCM and thereby provide affordable and equitable access to precision diagnostics and matched therapies for more patients.
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| 38. |
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| 39. |
- Berglund, P., et al.
(författare)
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Alcohols as enantioselective inhibitors in a lipase catalysed esterification of a chiral acyl donor
- 1995
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Ingår i: Biotechnology Letters. - 0141-5492. ; 17:1, s. 55-60
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Tidskriftsartikel (refereegranskat)abstract
- Increased reaction rates and increased enantioselectivities were observed with decreased concentrations of n-alkanols when resolving 2-methyldecanoic acid by esterification catalysed by immobilised lipase from Candida rugosa at controlled water activities in cyclohexane. The enantioselectivity was found to be independent of the water activity in the reaction medium at the n-heptanol concentrations investigated. However, when n-decanol was used as the acyl acceptor, not only the alcohol concentration but also the water activity in the reaction medium, influenced the enantioselectivity. The results obtained showed that the low enantioselectivity seen at a high alcohol concentration could be explained by the alcohol influencing the apparent V(max)(S) and V(max)(R) differently.
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| 40. |
- Billnert, Robert, 1981, et al.
(författare)
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New information on the characteristics of 1 in. x 1 in. cerium bromide scintillation detectors
- 2011
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 647:1, s. 94-99
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Tidskriftsartikel (refereegranskat)abstract
- In view of highly demanded new and accurate data on prompt gamma-ray emission in nuclear fission a major part of investigations is directed towards the selection of suitable detector systems. Here we have studied a new type of crystal scintillation detectors made from cerium bromide (CeBr(3)). For the first time a full characterization of such a detector is presented in terms of energy resolution, pulse-height linearity, intrinsic activity and intrinsic timing resolution. In particular the latter one is very important for prompt fission gamma-ray studies, because the presence of fast neutrons, emitted in fission too, requires the time-of-flight method for their discrimination. The energy resolution has been found to be comparable to that of cerium-doped LaCl(3):Ce detectors at an efficiency comparable to the one of a LaBr(3):Ce detector of the same size. The intrinsic activity of the CeBr(3) crystal was observed to be much lower compared to lanthanum halide crystals. The intrinsic timing resolution of a coaxial 1 in. x 1 in. sized detector was measured relative to that of a previously characterized LaCl(3):Ce detector and found to be (326 +/- 7) Ps at (60)Co energies, which is in between those of a LaBr(3):Ce and a LaCl(3):Ce detector of same size.
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| 41. |
- Billnert, Robert, 1981, et al.
(författare)
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Novel Scintillation Detectors for Prompt Fission γ-Ray Measurements
- 2012
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Ingår i: Physics Procedia. - : Elsevier BV. - 1875-3884 .- 1875-3892. ; 31, s. 29-34
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Konferensbidrag (refereegranskat)abstract
- In this work we present first results from measurements of prompt fission γ-rays from the spontaneous fission in 252Cf. New and accurate data on corresponding γ-rays from the reactions 235U(nth,f) and 239Pu(nth,f) are highly demanded for the modeling of new Generation-IV nuclear reactor systems. For these experiments we employed scintillation detectors made out of new materials (LaBr3, LaCl3 and CeBr3), whose properties were necessary to know in order to obtain reliable results. Hence, we have characterized these detectors. In all the important properties these detectors outshine sodium-iodine detectors that where used in the 1970s, when the existing data had been acquired. Our finding is that the new generation of scintillation detectors is indeed promising, as far as an improved precision of the demanded data is concerned.
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| 42. |
- Busson, P., et al.
(författare)
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Preparation of mesogen-functionalized dendrimers for second-order nonlinear optics
- 2002
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Ingår i: Macromolecules. - : American Chemical Society (ACS). - 0024-9297 .- 1520-5835. ; 35:5, s. 1663-1671
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Tidskriftsartikel (refereegranskat)abstract
- Liquid crystalline dendrimers with peripheral mesogen-containing units have been prepared. Multistep synthesis with several selective reactions was used in the preparation of the mesogen-containing molecules, 4-[10-(hydroxycarbonyl)decyloxy]phenyl 4-[4'-(2-(R)-octyloxy)-3'-nitrophenyl]benzo ate and 4-[10-(hydroxycarbonyl)decyloxy]biphenyl 4-[4'-(2-(R)-octyloxy)-3'-nitrophenyl]benzoate. Both molecules possessed an electron-accepting nitro group placed perpendicular to the long axis of the molecules in order to enhance the nonlinear optical activity. A second generation hydroxyl functional aliphatic dendrimer based on the dihydroxy acid, 2,2-bis(hydroxymethyl)propionic acid, was used as dendritic scaffold and was subsequently functionalized with the aforementioned groups. The purity and structure of the two liquid crystalline dendrimers were determined by H-1 NMR spectroscopy, size exclusion chromatography, and elemental analysis. The synthesis of both the mesogen-containing units and the liquid crystalline dendrimers is described in detail. Investigation of the liquid crystalline properties of the materials by differential scanning calorimetry and optical microscopy showed that they exhibited different mesophases, including the chiral smectic C phase. Ferroelectric switching was observed in this tilted phase, and electrooptical properties, including tilt angle and spontaneous polarization measurements, were investigated. Finally, the nonlinear optical properties of one of the materials were preliminary characterized.
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| 43. |
- Bäcke, Maria, et al.
(författare)
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A TESOL Practicum in Sweden
- 2019
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Ingår i: Current perspectives on the TESOL Practicum. - Cham : Springer. - 9783030287559 - 9783030287580 - 9783030287566 ; , s. 247-263
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Bokkapitel (refereegranskat)abstract
- In the purportedly egalitarian society of Sweden, with a self-proclaimed feminist government stressing that any inequalities should be minimized, and democratic values taught, one of the roles of pre-service teachers is to teach the values of Swedish society entextualized in the national curriculum. This implies teaching democracy and equal/human rights – in theory as well as in practice. With Foucault’s work on power as well as Deleuze’s and Guattari’s notions of smooth and striated space as backdrops, this chapter discusses how pre-service teachers can discover patterns of power and subversion and learn how to manage their own power in a balanced manner. An increased awareness of the mechanisms of power, and respect for everyone else’s equal rights as well as one’s own, should also have the goal and possibility of creating a sustainable classroom environment. With Swedish policy as a foundation, and knowledge of cultural differences and power structures, pre-service teachers can become teachers who convey information, read and affect the power strategies in their environment in a balanced manner, while working for democracy and equal rights more easily and successfully. © Springer Nature Switzerland AG 2019.
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| 44. |
- Claesson, Hans, et al.
(författare)
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Rheological behaviour during UV-curing of a star-branched polyester
- 2002
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Ingår i: Progress in organic coatings. - 0300-9440 .- 1873-331X. ; 44:1, s. 63-67
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Tidskriftsartikel (refereegranskat)abstract
- Using a rheometer coupled with an UV-light generator, the viscoelastic behaviour during the fast cure of star-branched polyester is investigated. The 32 arm star polymers consist of a hyperbranched polyester core, Boltorn(TM) and linear grafts of poly(E-caprolactone) (degree of polymerisation: 20-52) with methacrylate end groups. The resins are crystalline and the melting points range from 34 to 50degreesC; films can be formed and cured below 80degreesC. The crossover of G' and G was used as the gel point. The time to reach the gel point, a few seconds, increases linearly with molecular weight.
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| 45. |
- Dahlstrand, U, et al.
(författare)
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Identification of tumor margins using diffuse reflectance spectroscopy with an extended-wavelength spectrum in a porcine model
- 2018
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Ingår i: Skin Research and Technology. - : Wiley. - 0909-752X. ; 24:4, s. 667-671
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined border and the histological border was measured by 3 independent examiners.RESULTS: The median difference between the EWDRS-defined border and the histological border was 70 μm toward the pigmented tissue (range: -579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.CONCLUSIONS: Extended-wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non-invasive tumor margin delineation in the future.
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| 46. |
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| 47. |
- Eklund, Patrik, 1958-, et al.
(författare)
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The logic of geriatrics
- 2013
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Ingår i: The Journal of Nutrition, Health & Aging. - : Springer. - 1279-7707 .- 1760-4788. ; 17:1, s. 305-306
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Tidskriftsartikel (refereegranskat)
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| 48. |
- Ekström, Lars, 1959, et al.
(författare)
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Intervertebral disc response to cyclic loading--an animal model.
- 1996
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Ingår i: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine. - 0954-4119. ; 210:4, s. 249-58
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Tidskriftsartikel (refereegranskat)abstract
- The viscoelastic response of a lumbar motion segment loaded in cyclic compression was studied in an in vivo porcine model (N = 7). Using surgical techniques, a miniaturized servohydraulic exciter was attached to the L2-L3 motion segment via pedicle fixation. A dynamic loading scheme was implemented, which consisted of one hour of sinusoidal vibration at 5 Hz, 50 N peak load, followed by one hour of restitution at zero load and one hour of sinusoidal vibration at 5 Hz, 100 N peak load. The force and displacement responses of the motion segment were sampled at 25 Hz. The experimental data were used for evaluating the parameters of two viscoelastic models: a standard linear solid model (three-parameter) and a linear Burger's fluid model (four-parameter). In this study, the creep behaviour under sinusoidal vibration at 5 Hz closely resembled the creep behaviour under static loading observed in previous studies. Expanding the three-parameter solid model into a four-parameter fluid model made it possible to separate out a progressive linear displacement term. This deformation was not fully recovered during restitution and is therefore an indication of a specific effect caused by the cyclic loading. High variability was observed in the parameters determined from the 50 N experimental data, particularly for the elastic modulus E1. However, at the 100 N load level, significant differences between the models were found. Both models accurately predicted the creep response under the first 800 s of 100 N loading, as displayed by mean absolute errors for the calculated deformation data from the experimental data of 1.26 and 0.97 percent for the solid and fluid models respectively. The linear Burger's fluid model, however, yielded superior predictions particularly for the initial elastic response.
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| 49. |
- Eland, John H. D., 1941, et al.
(författare)
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Dissociation of multiply charged ICN by Coulomb explosion
- 2016
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 145:7
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Tidskriftsartikel (refereegranskat)abstract
- The fragmentations of iodine cyanide ions created with 2 to 8 positive charges by photoionization from inner shells with binding energies from 59 eV (I 4d) to ca. 900 eV (I 3p) have been examined by multi-electron and multi-ion coincidence spectroscopy with velocity map imaging ion capability. The charge distributions produced by hole formation in each shell are characterised and systematic effects of the number of charges and of initial charge localisation are found. Published by AIP Publishing.
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| 50. |
- Eland, John H. D., 1941, et al.
(författare)
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Double and Triple Ionisation of Isocyanic Acid
- 2020
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Double and triple ionisation spectra of the reactive molecule isocyanic acid (HNCO) have been measured using multi-electron and ion coincidence techniques combined with synchrotron radiation and compared with high-level theoretical calculations. Vertical double ionisation at an energy of 32.8±0.3eV forms the 3A” ground state in which the HNCO2+ ion is long lived. The vertical triple ionisation energy is determined as 65±1eV. The core-valence double ionisation spectra resemble the valence photoelectron spectrum in form, and their main features can be understood on the basis of a simple and rather widely applicable Coulomb model based on the characteristics of the molecular orbitals from which electrons are removed. Characteristics of the most important dissociation channels are examined and discussed.
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