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- Escala-Garcia, Maria, et al.
(författare)
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A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
- 2020
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Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies similar to 7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
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- Hahlin, A, et al.
(författare)
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Ultrathin Co films on flat and vicinal Cu(111) surfaces: per atom determination of orbital and spin moments
- 2003
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Ingår i: Journal of Physics: Condensed Matter. - : IOP Publishing. - 0953-8984. ; 15:5, s. 573-586
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Konferensbidrag (refereegranskat)abstract
- We have performed x-ray magnetic circular dichroism, x-ray resonant magnetic scattering and scanning tunnelling microscopy measurements on ultrathin Co films deposited on flat and vicinal Cu(111). The range of film thickness varies between one and 25 monolayers. For the vicinal Cu(111), Co deposition below one monolayer leads to the formation of elongated islands preferentially oriented along the step edges. These islands extend over lateral length scales of up to several thousand angstroms. For the thicker films we still observe that the vicinal surface leads to the occurrence of a preferential uniaxial growth direction. No such preferential growth direction can be identified for the flat surface. In correlation to the Co growth we observe an increase of both the orbital and the spin moment per Co atom on vicinal Cu(111) of about 25% versus what was observed for Co on flat Cu(111). This enhancement is observed in both the x-ray absorption and the reflectivity measurements. Similar to what was earlier reported for Co on Cu(100) we also observe for the case Co on Cu(111) an increase in the ratio m(l)/m(s), (orbital to spin moments) of 40% for thin Co films. In contrast to what has been reported for Co films on flat and vicinal Cu(100) we do not observe any major variations in the occupancy of the Co 3d states for Co grown on the vicinal Cu(111) surface.
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- Lemke, L, et al.
(författare)
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Magnetic extended x-ray absorption fine structure at the L-3,L-2 edges of 3d elements
- 1998
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Ingår i: JOURNAL OF PHYSICS-CONDENSED MATTER. - : IOP PUBLISHING LTD. - 0953-8984. ; 10:8, s. 1917-1930
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We report normal and magnetic extended x-ray absorption fine-structure (EXAFS) measurements made on 30 ML Fe films on Cu(001) substrates at the L-3,L-2 edges. The magnetic EXAFS at the L edges of 3d metals is particularly important as it can be used to pr
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- Removic-Langer, K, et al.
(författare)
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Spin and orbital moments in Au/Co/Au(111)/W(110) across the spin-reorientation transition-temperature
- 2003
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - 0168-583X. ; 200, s. 210-214
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Tidskriftsartikel (refereegranskat)abstract
- The temperature-driven spin-reorientation transition (SRT) has been investigated in a layer of 2.1 nm Co in Au/Co/Au. We studied the evolution and stability of the in-plane magnetization components in the temperature range from 300 to 90 K by means of polarized neutron reflectometry (PNR) and Co L-edge X-ray magnetic circular dichroism (XMCD) measurements. The PNR measurement provides evidence for the occurrence of a SRT in this temperature range. XMCD can be used as a vector magnetometer that yields both the in- and out-of-plane magnetization components per Co atom. Combining the results of both techniques (PNR and XMCD) allows separating the orbital and spin magnetic moments using magneto-optical sum rules. We observed that already above the SRT the in-plane orbital moment component changes significantly stronger than the spin component. (C) 2002 Elsevier Science B.V. All rights reserved.
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- Srivastava, P, et al.
(författare)
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Magnetic extended x-ray absorption fine structure at the L-3,L-2 edges of Fe and Co on Cu(001)
- 1998
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Ingår i: JOURNAL OF APPLIED PHYSICS. - : AMER INST PHYSICS. - 0021-8979. ; 83:11, s. 7025-7027
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We report magnetic extended x-ray absorption fine structure (EXAFS) measurements on 30 monolayer Fe and Co films on Cu(001) substrates at L-3,L-2 edges. For 3d transition metals, the magnetic EXAFS at the L edges is of great interest since it probes final
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