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- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 6. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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- Fawole, Henrietta O., et al.
(författare)
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Factors associated with fatigue in hip and/or knee osteoarthritis : A systematic review and best evidence synthesis
- 2021
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Ingår i: Rheumatology Advances in Practice. - : Oxford University Press (OUP). - 2514-1775. ; 5:1, s. 1-14
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Forskningsöversikt (refereegranskat)abstract
- Objective: The aim was systematically to identify and evaluate factors related to fatigue in individuals with hip and/or knee OA. Methods: A systematic literature search was conducted using AMED, CINAHL, MEDLINE, ProQuest and Web of Science Core Collections databases. Inclusion criteria comprised cross-sectional, case-control or longitudinal studies on patients with a diagnosis of hip and/or knee OA that included self-reported fatigue measures. Study quality was assessed using the National Heart, Lung and Blood Institute quality appraisal tool, and factors were synthesized within a bio-behavioural framework. Study designs and quality were combined to determine current evidence levels using best evidence synthesis grading. The full review protocol is available from PROSPERO (PROSPERO 2019: CRD42019138571). Results: Twenty-four studies were included, of which 19 were high, 4 moderate and 1 low quality. There was strong evidence of an association between poor self-reported physical function and high depressive symptoms with higher fatigue. Moderate evidence of an association was found between severe pain, high numbers of co-morbidities and low physical activity levels with higher fatigue. There was moderate or limited evidence of no association between most sociodemographic factors and radiographic OA severity with fatigue. Conclusion: Targets for fatigue management might include improving physical function, reducing depressive symptoms, pain and co-morbidities, and increasing physical activity levels. There is a need for more rigorous longitudinal studies to understand the causal effect of fatigue determinants within the hip and knee OA populations.
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- Okafor, Christian M. F., et al.
(författare)
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Cellular responses to modified Plasmodium falciparum MSP1(19) antigens in individuals previously exposed to natural malaria infection
- 2009
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Ingår i: Malaria Journal. - : Springer Science and Business Media LLC. - 1475-2875. ; 8, s. 263-
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Tidskriftsartikel (refereegranskat)abstract
- Background: MSP1 processing-inhibitory antibodies bind to epitopes on the 19 kDa C-terminal region of the Plasmodium falciparum merozoite surface protein 1 (MSP1(19)), inhibiting erythrocyte invasion. Blocking antibodies also bind to this antigen but prevent inhibitory antibodies binding, allowing invasion to proceed. Recombinant MSP1(19) had been modified previously to allow inhibitory but not blocking antibodies to continue to bind. Immunization with these modified proteins, therefore, has the potential to induce more effective protective antibodies. However, it was unclear whether the modification of MSP1(19) would affect critical T-cell responses to epitopes in this antigen. Methods: The cellular responses to wild-type MSP1(19) and a panel of modified MSP1(19) antigens were measured using an in-vitro assay for two groups of individuals: the first were malaria-nave and the second had been naturally exposed to Plasmodium falciparum infection. The cellular responses to the modified proteins were examined using cells from malaria-exposed infants and adults. Results: Interestingly, stimulation indices (SI) for responses induced by some of the modified proteins were at least two-fold higher than those elicited by the wild-type MSP1(19). A protein with four amino acid substitutions (Glu27 -> Tyr, Leu31 -> Arg, Tyr34 -> Ser and Glu43 -> Leu) had the highest stimulation index (SI up to 360) and induced large responses in 64% of the samples that had significant cellular responses to the modified proteins. Conclusion: This study suggests that specific MSP1(19) variants that have been engineered to improve their antigenicity for inhibitory antibodies, retain T-cell epitopes and the ability to induce cellular responses. These proteins are candidates for the development of MSP1-based malaria vaccines.
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- Idowu, Samuel O., 1985-
(författare)
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Applied Machine Learning in District Heating System
- 2018
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In an increasingly applied domain of pervasive computing, sensing devices are being deployed progressively for data acquisition from various systems through the use of technologies such as wireless sensor networks. Data obtained from such systems are used analytically to advance or improve system performance or efficiency. The possibility to acquire an enormous amount of data from any target system has made machine learning a useful approach for several large-scale analytical solutions. Machine learning has proved viable in the area of the energy sector, where the global demand for energy and the increasingly accepted need for green energy is gradually challenging energy supplies and the efficiency in its consumption.This research, carried out within the area of pervasive computing, aims to explore the application of machine learning and its effectiveness in the energy sector with dependency on sensing devices. The target application area readily falls under a multi-domain energy grid which provides a system across two energy utility grids as a combined heat and power system. The multi-domain aspect of the target system links to a district heating system network and electrical power from a combined heat and power plant. This thesis, however, focuses on the district heating system as the application area of interest while contributing towards a future goal of a multi-domain energy grid, where improved efficiency level, reduction of overall carbon dioxide footprint and enhanced interaction and synergy between the electricity and thermal grid are vital goals. This thesis explores research issues relating to the effectiveness of machine learning in forecasting heat demands at district heating substations, and the key factors affecting domestic heat load patterns in buildings.The key contribution of this thesis is the application of machine learning techniques in forecasting heat energy consumption in buildings, and our research outcome shows that supervised machine learning methods are suitable for domestic thermal load forecast. Among the examined machine learning methods which include multiple linear regression, support vector machine, feed forward neural network, and regression tree, the support vector machine performed best with a normalized root mean square error of 0.07 for a 24-hour forecast horizon. In addition, weather and time information are observed to be the most influencing factors when forecasting heat load at heating network substations. Investigation on the effect of using substation's operational attributes, such as the supply and return temperatures, as additional input parameters when forecasting heat load shows that the use of substation's internal operational attributes has less impact.
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- Ogunseye, Oluwafemi S., et al.
(författare)
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Harvesting knowledge from computer mediated social networks
- 2011
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Ingår i: Vine. - : Emerald. - 0305-5728 .- 1474-1032. ; 41:3, s. 252-264
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This paper aims to focus on how the advantages of computer mediated social networks (CMSN) can be effectively harnessed to create value for organizations in the form of ready knowledge and quick solutions to problems. Design/methodology/approach: A knowledge capture technique - the Delphi technique - was fused into the social networking process. A model was designed to help show how this can be achieved and further illustrated through a case study of the dotCSC intranet portal - a social networking project conceptualized and designed by the authors for the Department of Computer Science, in the authors' university. An online survey was carried out to determine the efficacy of the prototype dotCSC. Findings: The results show that, though computer mediated social networks are regarded as major sources of social capital development and potential sources of knowledge capital, there is still room for improvement in their present design if they are to be effectively used for knowledge creation and management attaining their optimum potential. Conversely, the bad spells and pitfalls of KM acceptance and deployment in organizations tend to be reduced when it is amalgamated with SN. The survey conducted showed that the users of the dotCSC enjoyed using the prototype as they would any other CMSN and that the strategies employed in the development of the dotCSC was effective in problem solving, knowledge creation, capturing, and indeed, management. Research limitations/implications: This improvement strategy is by no means exhaustive of the creative ways that knowledge capturing and management concepts can be combined and applied in the actual design of CMSNs for the benefit of organizations. It is meant to be an eye opener, a clarion call to developers and IS managers. It will also serve as a starting point into the future of objective KM oriented CMSN. Possible response bias from some respondents can be considered a primary limitation of the research. Originality/value: Looking through existing documentation and literature would show that this research presents a novel approach/model in the design of CMSNs. It is able to aid knowledge generation or synthesis in organizations by objectively structuring staff conversations through the CMSNs to facilitate knowledge management. It can also help organizations leverage the success and appeal of CMSN in their design of KMSs. © Emerald Group Publishing Limited.
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