| 1. |
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| 2. |
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| 3. |
- Karlqvist, Lena, et al.
(author)
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Computer mouse and track-ball operation : Similarities and differences in posture, muscular load and perceived exertion
- 1999
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In: International Journal of Industrial Ergonomics. - 0169-8141 .- 1872-8219. ; 23:3, s. 157-169
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Journal article (peer-reviewed)abstract
- Posture (optoelectronic 3D motion analysis system), muscular load (EMG), perceived exertion (rating scales), preference and productivity were investigated in 20 healthy VDU-operators (10 male and 10 female) during text editing with two different data input devices, a mouse and a track-ball. Work with the track-ball entailed lower shoulder elevation and less neck/shoulder muscle activity than work with the mouse. Arm support reduced muscle activity in the neck/shoulder region irrespective of input device used. A table height lower than 3 cm above elbow height allowed arm and shoulder support without undue shoulder elevation. Work with the track-ball entailed more wrist extension than work with the mouse. Perceived exertion ratings were lower for the shoulder and higher for the hand with track-ball than with mouse operation. Thus, biomechanical demands differ between different input devices. The women elevated and rotated their right shoulder outwards more than the men during work with both input devices. The overall EMG results showed a higher activity among the women than among the men in two of the examined muscles. This may relate to anthropometric differences which also influence biomechanical load moments. Another reason could be the observed differences in working techniques between the men and the women.
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| 4. |
- Karlqvist, Lena, et al.
(author)
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Computer mouse position as a determinant of posture, muscular loadand perceived exertion
- 1998
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In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 24:1, s. 62-73
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Journal article (peer-reviewed)abstract
- This study concerned the influence of 6 positions of the computer mouse on the work table on posture, muscular load, and perceived exertion during text editing. METHODS: An optoelectronic 3-dimensional motion analysis system was used to register the postures of 10 men and 10 women using video display units. Muscular load was also registered (with electromyography), as was perceived exertion (with rating scales). RESULTS: A neutral posture with a relaxed and supported arm showed the least perceived exertion, and the electromyographic results showed low activity in both trapezius muscles in this position. Short operators (all women) showed a numerically higher activity in the 4 examined muscles than the tall operators (all men, except 1). This finding could be related to lower muscle force among women and to anthropometric differences, which also influence biomechanic load moments. Narrow-shouldered operators (8 women and 1 man) and short operators worked with larger outward rotation and abduction of the shoulder in a position of the mouse lateral to the keyboard than the broad-shouldered (7 men and 2 women) and tall operators did. Arm support markedly reduced muscle load in the neck-shoulder region among the operators. CONCLUSIONS: The operators using video display units in this study preferred to use the mouse on a table in a close to relaxed, neutral posture of the arm in combination with arm support. Short and narrow-shouldered operators worked in more strenuous postures of the arm when the mouse was located lateral to the keyboard.
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| 5. |
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| 6. |
- Öberg, Ulrika, 1969-
(author)
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Finding a common ground : a pilot implementation of digital self-managment support in Swedish primary health care
- 2019
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Doctoral thesis (other academic/artistic)abstract
- Background: Due to an ageing, multi-diseased population, type 2 diabetes (T2D) and other chronic conditions pose a challenge for primary healthcare. To meet such challenges, primary healthcare nurses must adapt to new roles and acquire new skills regarding self-management support. eHealth and digital solutions are suggested to facilitate the increasing need for care in chronic conditions. However, how these solutions are experienced among users has not yet been sufficiently explored. To successful implement new working methods in primary healthcare, it is important to identify prerequisites and barriers that exists.Aim: The overall aim of this thesis was to explore perceptions among primary healthcare nurses and patients about digital self-management support in T2D and also to develop and evaluate a digital screening instrument assessing individual needs for self-management support. This thesis is based on four papers. Papers I and II aimed to describe perceptions among primary healthcare nurses and persons with T2D of using eHealth services for self-management support. Paper III aimed to develop and psychometrically test a screening instrument for person-centred guidance and self-management support. Paper IV aimed to describe diabetes specialist nurses’ experiences of a pilot implementation of the instrument labelled the Self-Management Assessment Scale (SMASc) as a basis for person-centred digital self-management support.Methods: A combined approach was used to collect and analyse data. Data in the qualitative studies were collected by means of focus group interviews (I) and individual interviews (II, IV) as well as participant observations (IV) were analysed using qualitative content analysis (I, II, IV). Quantitative data in study III were psychometrically tested. The participants in the respective studies were in Paper I primary healthcare nurses (n = 24), in Papers II and III persons with T2D (n = 11; n = 104) and in Paper IV diabetes specialist nurses (n = 5) and persons with T2D (n = 14). All data were collected in a county in northern Sweden.Results: The overall results constituted a web of mixed experiences and feelings towards using digital self-management support. Primary healthcare nurses pronounced their ambivalence towards the digital development in healthcare (I). Patients as well had mixed feelings, but they also pronounced benefits and potentials leading to increased involvement and empowerment (II). The psychometric assessment of the screening instrument, SMASc, demonstrated high potential and promising results for clinical assessments on factors affecting self-management behaviours (III). Preliminary results suggest that the SMASc instrument is considered suitable for screening of patients’ needs for self-management support (IV). Conclusion: The results of this thesis suggest that digitalization needs stepwise implementation. Digital tools such as the SMASc instrument can be useful in facilitating identification of patients in need of targeted interventions. However, primary healthcare nurses must be open to discussing patients’ emotional adaptation to the disease as well as the knowledge, sometimes not evidence based, the patients may have obtained from Internet sources. Targeted self-management support including person-centred guidance is suggested to be an effective way to achieve patient.
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| 7. |
- Ahluwalia, Bani, et al.
(author)
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Effects of Aloe barbadensis Mill. extract (AVH200 (R)) on human blood T cell activity in vitro
- 2016
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In: Journal of Ethnopharmacology. - : Elsevier BV. - 0378-8741 .- 1872-7573. ; 179, s. 301-309
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Journal article (peer-reviewed)abstract
- Ethnopharmacological relevance: Aloe barbadensis Mill. (Aloe vera) is a widely used medicinal plant well reputed for its diverse therapeutic applications. It has been used for thousands of years in folk medicine to treat various conditions and the Aloe vera gel has been reported to possess anti-inflammatory as well as immunostimulatory and immunomodulatory properties. However, the mode of action is still unclear. Aim of the study: The aim of this study was determine the effects of two well-defined A. barbadensis Mill. extracts AVH200 (R) and AVE200 on human blood T cells in vitro. Materials and methods: Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in the presence or absence of AVH200 (R) and AVE200. The T cell phenotype was investigated by flow cytometry, cell proliferation was determined by CFSE dye and thymidine assay, respectively and cytokine secretion was determined by MSD (R) Multi-Spot Assay system and ELISA. Results: The presence of AVH200 (R) resulted in a reduced expression of CD25 among CD3(+) T cells and suppression of T cell proliferation in a dose dependent manner. Furthermore, AVH200 (R) reduced the expression of CD28 on CD3(+) T cells. AVH200 (R) also reduced the secretion of IL-2, IFN-gamma and IL-17A in PBMC cultures. The AVH200 (R) dose dependent reduction in T cell activation and proliferation recorded in the cell cultures was not due to apoptosis or cell death. Additionally, AVH200 (R) was found to be more effective as compared to AVE200 in reducing T cell activation and proliferation. Conclusion: AVH200 (R) has the potential to reduce the activation, proliferation and cytokine secretion of healthy human blood T cells. Our study suggests that AVH200 (R) has a suppressive effect on human blood T cells in vitro.
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| 8. |
- Alsiö, Johan, et al.
(author)
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Impact of nandrolone decanoate on gene expression in endocrine systems related to the adverse effects of anabolic androgenic steroids
- 2009
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In: Basic & Clinical Pharmacology & Toxicology. - : Wiley. - 1742-7835 .- 1742-7843. ; 105:5, s. 307-314
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Journal article (peer-reviewed)abstract
- Elite athletes, body builders and adolescents misuse anabolic-androgenic steroids (AAS) in order to increase muscle mass or to enhance physical endurance and braveness. The high doses misused are associated with numerous adverse effects. The purpose of this study was to evaluate the impact of chronic supratherapeutic AAS treatment on circulating hormones and gene expression in peripheral tissues related to such adverse effects. Quantitative real-time PCR was used to measure expression levels of in total 37 genes (including peptide hormones, cell membrane receptors, nuclear receptors, steroid synthesising enzymes and other enzymes) in the pituitary, testes, adrenals, adipose tissue, kidneys and liver of male Sprague-Dawley rats after 14-day administration of the AAS nandrolone decanoate, 3 or 15 mg/kg. Plasma glucose and levels of adrenocorticotropic hormone (ACTH), adiponectin, corticosterone, ghrelin, insulin and leptin were also measured. We found several expected effects on the hypothalamic-pituitary-gonadal axis, while the treatment also caused a number of other not previously identified changes in circulating factors and gene transcription levels such as the dose-dependent reduction of the beta(3)-adrenergic receptor in adipose tissue, reduction of both circulating and mRNA levels of adiponectin, up-regulation of both hydroxymethylglutaryl-CoA-reductase, the rate-limiting enzyme in de novo synthesis of cholesterol, and the receptor for ACTH in the adrenals. The results provide evidence for wide ranging effects of AAS on the hypothalamic-pituitary-adrenal axis, adipose tissue and substrates of the renal control of blood pressure.
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| 9. |
- Ambjörn, Lena, et al.
(author)
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Qusta ibn Luqa and his production : A survey of an Arabic treatise on dental-nerve dysfunction
- 2007
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In: The professorship of Semitic languages at Uppsala University 400 years : jubilee volume from a symposium held at the University Hall, 21-23 September 2005 / Studia Semitica Uppsaliensia. - 0585-5535. - 9789155469207 ; 24, s. 69-85
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Book chapter (peer-reviewed)abstract
- This paper concerns the history of medicine, particularly formal medieval medicine in the Islamic cultural sphere. It focusses on the 9th century physician Qusta ibn Luqa and his production, and includes a survey of the contents of a hitherto unpublished Arabic treatise, attributed to Qusta ibn Luqa, on dental-nerve dysfunction.
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| 10. |
- Backström, Tomas, et al.
(author)
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Regisserad kompetensutveckling
- 2008
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In: Nordisk arbetslivsforskningskonferens. - Växjö.
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Conference paper (other academic/artistic)
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| 11. |
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| 12. |
- Bennet, Sean, et al.
(author)
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Global Cytokine Profiles and Association With Clinical Characteristics in Patients With Irritable Bowel Syndrome
- 2016
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In: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 0002-9270 .- 1572-0241. ; 111:8, s. 1165-1176
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Evidence suggests that patients with irritable bowel syndrome (IBS) have an altered cytokine profile, although it is unclear whether cytokines are linked with symptom severity. We aimed to determine whether global serum and mucosal cytokine profiles differ between IBS patients and healthy subjects and whether cytokines are associated with IBS symptoms. METHODS: Serum from 144 IBS patients and 42 healthy subjects was analyzed for cytokine levels of interleukin (IL)-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, interferon (IFN)-gamma and tumor necrosis factor (TNF) by MSD MULTI-ARRAY. In total, 109 IBS and 36 healthy sigmoid colon biopsies were analyzed for mRNA expression of IL-8, IL-10, TNF, and FOXP3 by quantitative reverse transcription PCR. Multivariate discrimination analysis evaluated global cytokine profiles. Rectal sensitivity, oroanal transit time, and psychological and gastrointestinal symptom severity were also assessed. RESULTS: Global cytokine profiles of IBS patients and healthy subjects overlapped, but cytokine levels varied more in IBS patients. Serum levels of IL-6 and IL-8 tended to be increased and levels of IFN-gamma tended to be decreased in IBS patients. Mucosal mRNA expression of IL-10 and FOXP3 tended to be decreased in IBS patients. Within both the full study cohort and IBS patients alone, serum level of TNF was associated with looser stool pattern, while subjects with more widespread somatic symptoms had increased serum levels of IL-6. Although neither IBS bowel habit subgroups nor patients with possible post-infectious IBS were associated with distinct cytokine profiles, a small cluster of IBS patients with comparatively elevated immune markers was identified. CONCLUSIONS: Global cytokine profiles did not discriminate IBS patients from healthy subjects, but cytokine profiles were more varied among IBS patients than among healthy subjects, and a small subgroup of patients with enhanced immune activity was identified. Also, association of inflammatory cytokines with some clinical symptoms suggests that immune activation may be of importance in a subset of IBS patients.
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| 13. |
- Bergh, Jonas C. S., et al.
(author)
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Docetaxel, trastuzumab, pertuzumab versus trastuzumab emtansine as neoadjuvant treatment of HER2-positive breast cancer : results from the Swedish PREDIX HER2 trial identifying a new potential de-escalation standard?
- 2019
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In: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 37:15, s. 501-501
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Journal article (other academic/artistic)abstract
- Background: Neoadjuvant therapy produces high rates of pathological complete response (pCR) and is the standard of care in HER2 positive breast cancer; however, the optimal treatment regimen remains to be established. Methods: In this randomized phase II study patients ≥18 years with HER2 positive breast cancer > 20mm or verified lymph node metastases were randomized to 6 courses of docetaxel, trastuzumab and pertuzumab (DTP, group A) or trastuzumab emtansine (T-DM1, group B), q 21 days. The protocol allowed switch to the competing treatment upon lack of response or drug-related severe toxicity. Patients received postoperative epirubicin+cyclophosphamide, trastuzumab for a total of one year and endocrine therapy. Accrual was completed in October 2018 after randomization of 202 patients, data on pCR were available for 190 at the time for this abstract submission. Median age, 52 years (26-74), menopausal status, histological type and grade were well balanced between the treatment groups. 62.6% of the tumors were hormone receptor (HR) positive. Results: Primary endpoint was pathological objective response. 190 patients completed the protocol-specified preoperative treatment. pCR was achieved in 45.3% of patients, 46.4% in patients treated with DTP and 44.1% with T-DM1 (chi-sq., p = 0.75). In HR-positive tumors, pCR was obtained in 35.3% of patients, 35.9% in group A vs. 34.6% in group B (p = 0.87); in HR-negative tumors, the overall pCR rate was 62.0%, 66.7% in group A vs. 57.9% in group B (p = 0.45). Severe (grade 3/4) toxicity was reported at 68 occasions related to DTP, compared with 16 related to T-DM1, 26 vs. 3 caused by febrile neutropenia. Significantly better quality of life was reported by patients treated with T-DM1. Conclusions: Our data on TDM-1 demonstrates similar efficacy and less toxicity, in particular for patients with HER2 and HR positive cancers, being a potential new standard for neoadjuvant therapy. Clinical trial information: NCT02568839.
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| 14. |
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| 15. |
- Bjornsdottir, Sigridur, et al.
(author)
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Circadian hormone profiles and insulin sensitivity in patients with Addison's disease : a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy
- 2015
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In: Clinical Endocrinology. - : Wiley. - 0300-0664 .- 1365-2265. ; 83:1, s. 28-35
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Journal article (peer-reviewed)abstract
- ContextConventional glucocorticoid replacement therapy in patients with Addison's disease (AD) is unphysiological with possible adverse effects on mortality, morbidity and quality of life. The diurnal cortisol profile can likely be restored by continuous subcutaneous hydrocortisone infusion (CSHI). ObjectiveThe aim of this study was to compare circadian hormone rhythms and insulin sensitivity in conventional thrice-daily regimen of glucocorticoid replacement therapy with CSHI treatment in patients with AD. Design and settingAn open, randomized, two-period, 12-week crossover multicentre trial in Norway and Sweden. PatientsTen Norwegian patients were admitted for 24-h sampling of hormone profiles. Fifteen Swedish patients underwent euglycaemic-hyperinsulinaemic clamp. InterventionThrice-daily regimen of oral hydrocortisone (OHC) and CSHI treatment. Main outcome measureWe measured the circadian rhythm of cortisol, adrenocorticotropic hormone (ACTH), growth hormone (GH), insulin-like growth factor-1, (IGF-1), IGF-binding protein-3 (IGFBP-3), glucose, insulin and triglycerides during OHC and CSHI treatment. Euglycaemic-hyperinsulinaemic clamp was used to assess insulin sensitivity. ResultsContinuous subcutaneous hydrocortisone infusion provided a more physiological circadian cortisol curve including a late-night cortisol surge. ACTH levels showed a near normal circadian variation for CSHI. CSHI prevented a continuous decrease in glucose during the night. No difference in insulin sensitivity was observed between the two treatment arms. ConclusionContinuous subcutaneous hydrocortisone infusion replacement re-established a circadian cortisol rhythm and normalized the ACTH levels. Patients with CSHI replacement had a more stable night-time glucose level compared with OHC without compromising insulin sensitivity. Thus, restoring night-time cortisol levels might be advantageous for patients with AD.
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| 16. |
- Brandberg, Yvonne, et al.
(author)
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Health-related quality of life in the Swedish PREDIX HER2 trial, evaluating docetaxel, trastuzumab, pertuzumab versus trastuzumab emtansine as neoadjuvant treatment of HER2-positive breast cancer.
- 2019
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In: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 37:15, s. 583-583
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Journal article (other academic/artistic)abstract
- Background: Neoadjuvant therapy combining docetaxel, trastuzumab and pertuzumab (DTP) was compared to trastuzumab emtansine (T-DM1) in the randomized phase 2 PREDIX HER2 trial. Patients, ≥18 years with HER2 positive breast cancer, ≥20mm or with verified lymph node metastases, were randomized to six courses of DTP (Standard arm) or T-DM1 (Experimental arm). Primary endpoint was pathological objective response to primary medical therapy at post-treatment surgery. Health related quality of life (HRQoL) was a secondary outcome, and is of specific interest as there was no difference between the randomization groups regarding the main endpoint (results presented in a separate abstract sent to ASCO 2019, Bergh et al.). Methods: Of 202 randomized patients, 190 are available for evaluation at this point. HRQoL was measured, using EORTC QLQ-C30 + EORTC QLQ-BR23, at baseline before randomization and after six courses. Results: No differences between the randomization arms were found at baseline. Results after six courses, based on 163 patients (86%) and adjusted to baseline values, revealed statistical significant differences (p≤0.01), favoring the experimental T-DM1 arm on 7 out of 15 of the EORTC QLQ-C30 variables (Physical functioning, Role functioning, Social functioning, Global quality of Life, Fatigue, Dyspnea, and Diarrhea). For the breast cancer specific questionnaire (EORTC-BR23), the experimental arm scored statistically significantly better on 5 out of 7 subscales (Body image, Sexual functioning, Sexual enjoyment, Systemic therapy side effects and Upset by hair loss). All of the statistical significant differences were of moderate or large clinical significance (≥10 scale scores). No differences between the randomization arms were found for the remaining HRQoL variables. Conclusions: The experimental arm reported better HRQoL than the control arm after six courses. Trastuzumab emtansine may be a useful treatment alternative due to better HRQoL and lower toxicity. Clinical trial information: NCT02568839.
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| 17. |
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| 18. |
- Brattsand, Göran, et al.
(author)
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Equalis/SFKK rekommenderar harmonisering av enheter vid hormonbestämningar -Något också för Norden?
- 2012
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In: Klinisk Biokemi i Norden. - 1101-2013. ; 24:4, s. 20-27
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Journal article (peer-reviewed)abstract
- Equalis och Svensk Förening för Klinisk Kemi (SFKK) rekommenderar att de kliniska laboratorierna i Sverige använder enhetliga måttenheter vid hormonbestämningar för ökad jämförbarhet och patientsäkerhet. Vid analys i serum eller plasma med nuvarande metoder rekommenderas följande enheter:• Adrenokortikotropt hormon (ACTH): pmol/L• Insulin: mIE/L• Parathormon (PTH): pmol/L• Prolaktin: mIE/L• Tillväxthormon (GH): μg/L• Östradiol: pmol/L• Aldosteron: pmol/L• Reninkoncentration: mIE/L
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| 19. |
- Christensen, Torben Røjle, et al.
(author)
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Tracing the climate signal : mitigation of anthropogenic methane emissions can outweigh a large Arctic natural emission increase
- 2019
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1
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Journal article (peer-reviewed)abstract
- Natural methane emissions are noticeably influenced by warming of cold arctic ecosystems and permafrost. An evaluation specifically of Arctic natural methane emissions in relation to our ability to mitigate anthropogenic methane emissions is needed. Here we use empirical scenarios of increases in natural emissions together with maximum technically feasible reductions in anthropogenic emissions to evaluate their potential influence on future atmospheric methane concentrations and associated radiative forcing (RF). The largest amplification of natural emissions yields up to 42% higher atmospheric methane concentrations by the year 2100 compared with no change in natural emissions. The most likely scenarios are lower than this, while anthropogenic emission reductions may have a much greater yielding effect, with the potential of halving atmospheric methane concentrations by 2100 compared to when anthropogenic emissions continue to increase as in a business-as-usual case. In a broader perspective, it is shown that man-made emissions can be reduced sufficiently to limit methane-caused climate warming by 2100 even in the case of an uncontrolled natural Arctic methane emission feedback, but this requires a committed, global effort towards maximum feasible reductions.
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| 20. |
- Dahlén, Rahil, et al.
(author)
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Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cells in vitro from Patients with Clinically Active Ulcerative Colitis
- 2013
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In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475. ; 78:3, s. 275-284
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Journal article (peer-reviewed)abstract
- Many patients with inflammatory bowel disease (IBD) are undergoing therapy with infliximab, an antibody specific for TNF. However, the exact mechanisms of action of infliximab are not completely understood. The aim of this study was to determine the in vitro effects of infliximab on blood T cells derived from anti-TNF therapy-naive ulcerative colitis (UC) patients with clinically active disease. Peripheral blood mononuclear cells were stimulated polyclonally or by antigen in the presence or absence of infliximab. The T cell phenotype was investigated by flow cytometry, cytokine secretion was determined by ELISA, and cell proliferation was determined by thymidine assay or CFSE dye. Presence of infliximab resulted in reduced expression of CD25 in CD4(+) and CD8(+) T cell populations and inhibited secretion of IFN-, IL-13, IL-17A, TNF as well as granzyme A. Infliximab also suppressed CD4(+) and CD8(+) T cell proliferation. These effects of infliximab were recorded both in T cells activated by polyclonal and antigen-specific stimulation. The effects of infliximab on T cell apoptosis and induction of FOXP3(+)CD4(+) T regulatory cells were ambiguous and depended on the originating cellular source and/or the stimulation mode and strength. In conclusion, infliximab is able to reduce T cell activation as measured by CD25, proliferation and cytokine secretion in vitro from UC patients with clinically active disease. These data suggest that suppression of T cell activity may be important for infliximab-mediated disease remission in patients with UC.
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| 21. |
- Dalin, Frida, 1984-, et al.
(author)
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Clinical and immunological characteristics of Autoimmune Addison's disease : a nationwide Swedish multicenter study
- 2017
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In: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 102:2, s. 379-389
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Journal article (peer-reviewed)abstract
- CONTEXT: Studies on clinical and immunological features of Autoimmune Addison's disease (AAD) are needed to understand the disease burden and increased mortality.OBJECTIVE: To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles and cardiovascular risk factors.DESIGN, SETTING AND PARTICIPANTS: Cross sectional, population-based study. 660 AAD patients were included utilizing the Swedish Addison Registry (SAR) 2008-2014. When analyzing cardiovascular risk factors, 3,594 individuals from the population-based survey in Northern Sweden, MONICA (MONItoring of Trends and Determinants of CArdiovascular Disease), served as controls.MAIN OUTCOME MEASURE: Prevalence of autoimmune comorbidities and cardiovascular risk factors. Autoantibodies against 13 autoantigens were determined.RESULTS: Sixty percent of the SAR cohort consisted of females. Mean age at diagnosis was significantly higher for females than for males (36.8 vs. 31.1 years). The proportion of 21-hydroxylase autoantibody positive patients was 83% and 62% of patients had one or more associated autoimmune diseases, more frequently coexisting in females (p<0.0001). AAD patients had lower BMI (p<0.0001) and prevalence of hypertension (p=0.027) compared with controls. Conventional hydrocortisone tablets were used by 89% of patients; with the mean dose 28.1±8.5 mg/day. The mean hydrocortisone equivalent dose normalized to body surface was 14.8±4.4 mg/m(2)/day. Higher hydrocortisone equivalent dose was associated with higher incidence of hypertension (p=0.046).CONCLUSIONS: Careful monitoring of AAD patients is warranted to detect associated autoimmune diseases. Contemporary Swedish AAD patients do not have increased prevalence of overweight, hypertension, T2DM or hyperlipidemia. However, high glucocorticoid replacement doses may be a risk factor for hypertension.
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| 22. |
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| 23. |
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| 24. |
- Forshammar, Johan, et al.
(author)
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A pilot study of colonic B cell pattern in irritable bowel syndrome
- 2008
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In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 43:12, s. 1461-6
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Low-grade gastrointestinal inflammation has been reported in patients with irritable bowel syndrome (IBS). However, the colonic B-cell pattern has not been investigated in these patients. Therefore, the aim of this pilot study was to investigate the distribution and isotype of immunoglobulin-producing B cells in the colonic mucosa of IBS patients. MATERIAL AND METHODS: Patients with IBS (n=12) fulfilling the Rome II criteria were compared with controls (n=11). Immunohistochemical staining of biopsies from the sigmoid and ascending colon was performed. RESULTS: The number of IgA(+) B cells in the ascending colon was lower in IBS patients than in controls (p=0.039). Furthermore, unlike controls, IBS patients had a reduction of IgA(+) B cells in the ascending colon relative to the sigmoid colon (p=0.04). Neither the IgG(+), nor the IgM(+) colonic B-cell numbers differed between IBS patients and controls. Very few colonic IgE(+) cells were detected and there was no difference between the two subject groups. CONCLUSIONS: The reduced number of colonic IgA(+) B cells in IBS patients suggests that the disorder may be associated with a modified gut immune defence. Whether this phenomenon is causally related to symptoms remains unknown and merits further investigation in a larger group of patients.
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| 25. |
- Fredlund, Kerstin, 1954, et al.
(author)
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Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate
- 2006
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In: Journal of Trace Elements in Medicine and Biology. - : Elsevier BV. - 0946-672X. ; 20:1, s. 49-57
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Journal article (peer-reviewed)abstract
- The dose-dependent inhibitory effect of sodium phytate (myo-inositol-hexaphosphate) on absorption of zinc and retention of calcium was studied in man. No systematic study of this dose-response effect has been reported to this time. Forty subjects were served meals containing white wheat rolls without/with additions of phytate. Ten subjects were given test meals containing one or two of the studied levels of phytate and in addition all subjects were served meals to which no phytate was added. The zinc content was 3.1 mg (47 mu mol) and the calcium content 266 mg (6.6 mmol). The rolls were labelled extrinsically with radioisotopes, Zn-65 and Ca-47, and whole-body retention of both minerals was measured. Totally 105 meals were served, 36 meals in which no phytate was added and 9-10 meals on each level of phytate. The zinc absorption in meals to which either 0, 25, 50, 75, 100, 140, 175 or 250 mg of phytate-P (0, 134, 269, 403, 538, 753, 941 or 1344 mu mol phytate) had been added was 22%, 16%, 14%, 11%, 7%, 7%, 7% and 6%, respectively (mean values). The addition of 50 mg phytate-P or more significantly decreased zinc absorption (p = 0.01) as compared to absorption from the test meals with no added phytate. The calcium retention at day 7 in the same meals was 31%, 28%, 27%, 26%, 22%, 19%, 14% and 11% (mean values). The addition of 100 mg phytate-P or more significantly decreased calcium retention (p = 0.03) compared to the test meals with no added phytate. It was concluded that the inhibitory effect of phytate on the absorption of zinc and the retention of calcium was dose dependent.
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| 27. |
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| 30. |
- Hallberg, Ludvig, et al.
(author)
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Decreased aldosterone in the plasma of suicide attempters with major depressive disorder.
- 2011
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In: Psychiatry Research. - : Elsevier BV. - 1872-7123 .- 0165-1781. ; 187, s. 135-139
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Journal article (peer-reviewed)abstract
- Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating Scale (CPRS), including the Montgomery-Asberg Depression Rating Scale (MADRS) and the Brief Scale for Anxiety (BSA). Plasma samples were frozen immediately after collection and stored at -80 degrees C for 5-18years. Aldosterone and renin levels were analyzed using radioactive- and chemiluminescent immunoassays. We found that suicide attempters with MDD had significantly lower plasma levels of aldosterone than the other patient groups, as well as than the healthy controls. Moreover, increasing severity of psychiatric symptoms was associated with lower aldosterone levels in the suicide attempters with MDD. Non-suicidal patients with MDD did not differ significantly compared to healthy controls with respect to aldosterone and renin levels. These findings may indicate that low aldosterone levels could be a marker of suicidality in patients with MDD.
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| 31. |
- Hatschek, Thomas, et al.
(author)
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Neoadjuvant Trastuzumab, Pertuzumab, and Docetaxel vs Trastuzumab Emtansine in Patients With ERBB2-Positive Breast Cancer A Phase 2 Randomized Clinical Trial
- 2021
-
In: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 7:9, s. 1360-1367
-
Journal article (peer-reviewed)abstract
- IMPORTANCE: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown.OBJECTIVE: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients with ERBB2 (formerly HER2)-positive breast cancer.DESIGN, SETTING, AND PARTICIPANTS: This randomized phase 2 trial, conducted at 9 sites in Sweden, enrolled 202 patients between December 1, 2014, and October 31, 2018. Participants were 18 years or older, with ERBB2-positive tumors larger than 20 mm and/or verified lymph node metastases. Analysis was performed on an intention-to-treat basis.INTERVENTIONS: Patients were randomized to receive 6 cycles of DTP (standard group) or T-DM1 (investigational group). Crossover was recommended at lack of response or occurrence of intolerable toxic effects. Assessment with fluorine 18-labeled fluorodeoxyglucose (F-18-FDG) positron emission tomography combined with computed tomography (PET-CT) was performed at baseline and after 2 and 6 treatment cycles.MAIN OUTCOME AND MEASURES: Pathologic complete response, defined as ypT0 or Tis ypN0. Secondary end points were clinical and radiologic objective response; event-free survival, invasive disease-free survival, distant disease-free survival, and overall survival; safety; health-related quality of life (HRQoL); functional and biological tumor characteristics; and frequency of breast-conserving surgery.RESULTS: Overall, 202 patients were randomized; 197 (99 women in the standard group [median age, 51 years (range, 26-73 years)] and 98 women in the investigational group [median age, 53 years (range, 28-74 years)]) were evaluable for the primary end point. Pathologic complete response was achieved in 45 patients in the standard group (45.5%; 95% CI 35.4%-55.8%) and 43 patients in the investigational group (43.9%; 95% CI 33.9%-54.3%). The difference was not statistically significant (P = .82). In a subgroup analysis, the pCR rate was higher in hormone receptor-negative tumors than in hormone receptor-positive tumors in both treatment groups (45 of 72 [62.5%] vs 45 of 125 [36.0%]). Three patients in the T-DM1 group experienced progression during therapy. In an exploratory analysis, tumor-infiltrating lymphocytes at 10% or more (median) estimated pCR significantly (odds ratio, 2.76; 95% CI, 1.42-5.36; P = .003). Response evaluation with F-18-FDG PET-CT revealed a relative decrease of maximum standardized uptake value by more than 31.3% (median) was associated with pCR (odds ratio, 6.67, 95% CI, 2.38-20.00; P < .001).CONCLUSIONS AND RELEVANCE: In this study, treatment with standard neoadjuvant combination DTP was equal to T-DM1.
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| 32. |
- Havervall, Sebastian, et al.
(author)
-
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection
- 2022
-
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 17:1, s. e0262169-e0262169
-
Journal article (peer-reviewed)abstract
- Current SARS-CoV-2 serological assays generate discrepant results, and the longitudinal characteristics of antibodies targeting various antigens after asymptomatic to mild COVID-19 are yet to be established. This longitudinal cohort study including 1965 healthcare workers, of which 381 participants exhibited antibodies against the SARS-CoV-2 spike antigen at study inclusion, reveal that these antibodies remain detectable in most participants, 96%, at least four months post infection, despite having had no or mild symptoms. Virus neutralization capacity was confirmed by microneutralization assay in 91% of study participants at least four months post infection. Contrary to antibodies targeting the spike protein, antibodies against the nucleocapsid protein were only detected in 80% of previously anti-nucleocapsid IgG positive healthcare workers. Both anti-spike and anti-nucleocapsid IgG levels were significantly higher in previously hospitalized COVID-19 patients four months post infection than in healthcare workers four months post infection (p = 2*10−23 and 2*10−13 respectively). Although the magnitude of humoral response was associated with disease severity, our findings support a durable and functional humoral response after SARS-CoV-2 infection even after no or mild symptoms. We further demonstrate differences in antibody kinetics depending on the antigen, arguing against the use of the nucleocapsid protein as target antigen in population-based SARS-CoV-2 serological surveys
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| 33. |
- Hellström-Westas, Lena, et al.
(author)
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Short term effects of incubator covers on quiet sleep in stable premature infants
- 2001
-
In: Acta Pædiatrica. - : Wiley. - 1651-2227 .- 0803-5253. ; 90:9, s. 1004-1008
-
Journal article (peer-reviewed)abstract
- Incubator covers are increasingly being used in neonatal care as part of minimal disturbance strategies. The aim of this study was to examine possible effects of incubator covers on sleep patterns in stable premature infants. Quiet sleep (QS) can be investigated by amplitude-integrated electroencephalography (aEEG) at 32–34 weeks gestational age. In nine premature infants (gestational ages 26–32 weeks, median 29) QS periods were measured at a postconceptional age of 32–34 weeks (median 34) during two consecutive 24 h periods, one period with a padded dark cover over the incubator and one period without the cover, in a randomized order. There were no significant differences between the two 24 h periods (with incubator cover and without cover, respectively) regarding the duration of the QS periods, the percentage of QS of the total recording time (% QS) or the duration of QS intervals. However, there was a positive correlation between postnatal age in days and the mean duration of QS periods when incubator covers were used (r = 0.90, p = 0.001). When the covers were used there was a difference between the girls and the boys in the duration of QS intervals (p = 0.032); the QS intervals increased in the five girls from median (range) 63.2 (49.4–94.6) min to 77.2 (59.3–100.9) min (p = 0.043). There was no difference in the duration of QS periods between girls and boys. Conclusion: Incubator covers seem to have some short-term effects on sleep quality in premature infants but the clinical significance and possible long-term effects are not known.
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| 34. |
- Holmén, Nathalie, 1979, et al.
(author)
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CD4+CD25+ regulatory T cells in irritable bowel syndrome patients.
- 2007
-
In: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. - : Wiley. - 1350-1925. ; 19:2, s. 119-25
-
Journal article (peer-reviewed)abstract
- The aetiology of the irritable bowel syndrome (IBS) is incompletely understood. A low-grade colonic inflammation is frequently seen, but it is unclear to what extent this phenomenon contributes to the pathophysiology of IBS. CD4(+)CD25(+) regulatory T cells (Treg) are implicated to play an important role in suppressing intestinal inflammation. We, therefore, examined whether the intestinal inflammatory process in IBS patients is the result of an altered function and/or frequency of CD25(+) Treg cells. Patients with IBS (n = 34), fulfilling the Rome II criteria, were compared with controls (n = 26). The suppressive activity of blood CD25(+) Treg cells was determined and the frequency of colonic and blood CD25(+) Treg cells was analysed by flow cytometry. The expression of the Treg marker, FOXP3 mRNA, in colonic biopsies was determined by reverse transcription-polymerase chain reaction. Blood CD25(+) Treg cells from IBS patients suppressed the proliferation of blood CD4(+)CD25(low/-) T cells. Similar frequencies of CD25(+) Treg cells were recorded in mucosa and blood of IBS patients and controls. FOXP3 mRNA was equally expressed in the colonic mucosa of patients with IBS and controls. In conclusion, the low-grade intestinal inflammation recorded in patients with IBS is not associated with an altered function or frequency of CD25(+) Treg cells.
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| 35. |
- Horev, L., et al.
(author)
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Preservatives in cosmetics in the Israeli market conform well to the EU legislation
- 2015
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In: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 1468-3083 .- 0926-9959. ; 29:4, s. 761-766
-
Journal article (peer-reviewed)abstract
- BackgroundPreservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must be present on the product or packaging. ObjectivesTo examine the use of preservatives in common cosmetics on the Israeli market. Materials/MethodsSixty different Israeli brand cosmetics, including shampoos, liquid soaps, body creams and hand creams were randomly selected. Ingredient labels were examined. The products were investigated by the chromotropic acid method for release of formaldehyde and by high performance liquid chromatography for the presence of formaldehyde, DMDM hydantoin and methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI content. ResultsAll products but one contained a detailed list of ingredients printed on the package. According to labelling, the most prevalent preservatives in Israeli shampoos and liquid soaps were DMDM hydantoin and MCI/MI. Hand creams and body creams contained mainly parabens but also iodopropynyl butylcarbamate, phenoxyethanol and DMDM hydantoin. Formaldehyde in doses from 4 to 429ppm, and DMDM hydantoin were detected in 38 and 16 (63% and 27%) of the products, respectively. MCI/MI was detected in 11 (18%) of the products, with highest prevalence in rinse- off products (55%). Excluding one hand cream which measured 106ppm MI, the amount of formaldehyde, DMDM hydantoin, MCI/MI and MI was within the allowed concentrations by the European directive in all cases. ConclusionsIn Israel, adaptation of the European directive prevails, as shown by the measurements we performed on randomly selected products.
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| 36. |
- Iribarren, Cristina, 1993, et al.
(author)
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Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids
- 2022
-
In: Neurogastroenterology and Motility. - : Wiley. - 1350-1925 .- 1365-2982. ; 34:10
-
Journal article (peer-reviewed)abstract
- Background: Alteration of the host-microbiota cross talk at the intestinal barrier may participate in the pathophysiology of irritable bowel syndrome (IBS). Therefore, we aimed to determine effects of fecal luminal factors from IBS patients on the colonic epithelium using colonoids. Methods: Colon-derived organoid monolayers, colonoids, generated from a healthy subject, underwent stimulation with fecal supernatants from healthy subjects and IBS patients with predominant diarrhea, phosphate-buffered saline (PBS), or lipopolysaccharide (LPS). Cytokines in cell cultures and fecal LPS were measured by ELISA and mRNA gene expression of monolayers was analyzed using Qiagen RT2 Profiler PCR Arrays. The fecal microbiota profile was determined by the GA-map (TM) dysbiosis test and the fecal metabolite profile was analyzed by untargeted liquid chromatography/mass spectrometry. Key results: Colonoid monolayers stimulated with fecal supernatants from healthy subjects (n = 7), PBS (n = 4) or LPS (n = 3) presented distinct gene expression profiles, with some overlap ((RY)-Y-2 = 0.70, Q(2) = 0.43). Addition of fecal supernatants from healthy subjects and IBS patients (n = 9) gave rise to different gene expression profiles of the colonoid monolayers ((RY)-Y-2 = 0.79, Q(2) = 0.64). Genes (n = 22) related to immune response (CD1D, TLR5) and barrier integrity (CLDN15, DSC2) contributed to the separation. Levels of proinflammatory cytokines in colonoid monolayer cultures were comparable when stimulated with fecal supernatants from either donor types. Fecal microbiota and metabolite profiles, but not LPS content, differed between the study groups. Conclusions: Fecal luminal factors from IBS patients induce a distinct colonic epithelial gene expression, potentially reflecting the disease pathophysiology. The culture of colonoids from healthy subjects with fecal supernatants from IBS patients may facilitate the exploration of IBS related intestinal micro-environmental and barrier interactions.
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| 37. |
- Isaksson, Anna
(author)
-
Att utmana förändringens gränser : En studie om förändringsarbete, partnerskap och kön med Equal-programmet som exempel
- 2010
-
Doctoral thesis (other academic/artistic)abstract
- In this thesis the overall aim is to analyse conceptions of change with the point of departure being texts developed within the framework of three development partnerships financed by the European Social Fund's Equal Programme 2001-2007. The development partnerships, consisting of collaborating parties from both the public and private sector, aimed at developing new methods and ideas in order to counteract discrimination and all kinds of inequality in working life. The thesis poses the following research questions: How are the problems that the development partnerships intended to counteract described? What appears as important to change in order for discrimination in working life to decrease? In what ways are changes aimed at combating discrimination and contributing to increased gender equality and diversity in working life deemed possible? What motives emerge behind the visions of creating a working life without discrimination? How are gender and other social categories constructed and how do these constructions impact on the conceptions of change that emerge? The ideas, perspectives and interests that characterise the understanding of changes in working life in the studied texts, are illustrated with the aid of theories on how society's forms of rule have changed from government to governance and theories on how gender is done. Furthermore, why certain perspectives and ideas emerge and the consequences of them is analysed based on institutional ethnography and concepts such as social relations and ruling relations. The thesis' analysis points to how the consensus-based organisational form of partnership and the politics and principles that are reflected in the Equal Programme together with notions on growth, leadership and gender create limits for the conceptions of change. Limits that in certain respects entail that society's relations of power and inequality, instead of being challenged, are reproduced. Based on the results of the study, the importance is emphasised of continuously taking one's point of departure in identifying and challenging the limits to how one can speak of change, since the dominant conceptions of change may be an expression of the ruling relations.
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| 38. |
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| 39. |
- Isaksson, Charlotta, 1974-, et al.
(author)
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Active, passive, non-existing or conditional? : Social relations shaping energy use at workplaces
- 2019
-
In: Energy Research & Social Science. - : Elsevier BV. - 2214-6296 .- 2214-6326. ; 51, s. 148-155
-
Journal article (peer-reviewed)abstract
- Energy efficiency concerns the entire workplace and a cooperative approach is important for achieving ambitious energy reduction targets. Despite this, many organisations still mainly regard energy efficiency as a technical issue involving just a few specialists. A focus on the social relations and processes that shape work on energy issues is lacking. The aim of this paper is to illuminate and explore social relations between the staff driving energy issues and their co-workers. The analysis presented is based upon two features shaping their mutual engagement for reducing energy use: the communication strategy on energy issues undertaken by the workplace and the support for energy efficiency and conservation among the staff. The study provides insights gained from an interview study done in a Swedish organisation as well as from social science research in the field. The result is a conceptual framework that describes four relationships between the drivers of change and their co-workers. These relationships are characterized as active, passive, non-existing and conditional engagement in energy efficiency and conservation. The framework can be used as a tool for identifying social constraints and possibilities for reducing the use of energy at workplaces as well as in other contexts. © 2019 Elsevier Ltd
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| 40. |
- Isaksson, Charlotta, et al.
(author)
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Kommunikation för hållbart arbete med energieffektivisering : En kunskapssammanställning om samverkan och kommunikation om energifrågor inom organisationer och företag
- 2017
-
Reports (other academic/artistic)abstract
- I den här kunskapssammanställningen har vi, med utgångspunkt i samhälls- och beteendevetenskaplig forskning, sammanställt kunskap om organisationers och företags energieffektiviseringsarbete. Syftet har varit att undersöka hur kommunikation och samverkan inom organisationer och företag kan stärkas för att främja ett hållbart arbete med energieffektivisering.Flera studier visar att energieffektivisering varken betraktas som strategiskt viktigt eller är premierat av olika aktörsgrupper inom organisationer och företag. Det är inte prioriterat av ledningen, som därmed inte heller väljer att investera i kostnadseffektiva energiåtgärder. De anställda betraktar energi som en ”underförstådd rättighet”. Fastighetsskötarnas inflytande att påverka energianvändningen är begränsad, liksom deras tid och resurser för detta. I tidigare forskning kan vi se att undermålig kommunikation mellan olika aktörsgrupper rörande energifrågor ger upphov till målkonflikter mellan olika intressen och skapar ett förhållningssätt att arbetet med energieffektivisering endast ligger hos fastighetsskötaren eller driftteknikern.Företag och organisationer som har ett mer framgångsrikt arbete med energieffektivisering gör det till en fråga som hela organisationen beaktar. Detta innebär att fler personer och aspekter av verksamheten involveras i organisationens strävan mot hållbarhet. Det sätter fokus på samverkan och kommunikation.I kunskapssammanställningen ger vi förslag på riktlinjer och rekommendationer om kommunikation, vilka kan verka som stöd för att arbeta med energieffektivisering inom företag och organisationer. Vi strukturerar dessa utifrån tre steg. Budskap som understryker att energieffektivisering är prioriterat och en angelägenhet för alla. Tillvägagångssätt som lyfter fram hur energieffektivisering kan kommuniceras via t ex riktlinjer, samtal, utbildning och visualisering. De valda tillvägagångssätten bör bli en del av organisationens verksamheter och vardagliga rutiner. Återkoppling av energianvändningen som visar om ansträngningarna är effektiva och ger resultat. Forskning pekar på att ju fler som är involverade i arbetet med energieffektivisering desto bättre tenderar resultatet att bli. Goda resultat är i sin tur ett viktigt motiv till fortsatt arbete.
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| 41. |
- Isaksson, Mats, 1961, et al.
(author)
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Calculations of the deposition of 137Cs from nuclear bomb tests and from the Chernobyl accident over the province of Skane in the southern part of Sweden based on precipitation
- 2000
-
In: Journal of Environmental Radioactivity. - 0265-931X .- 1879-1700. ; 49, s. 97-112
-
Journal article (peer-reviewed)abstract
- The deposition of 137Cs over the province of Skane (an area of about 100x100km2) in the southern part of Sweden has been investigated. The origin of the deposition of 137Cs is, in about equal parts, from nuclear weapons tests and from the Chernobyl nuclear accident and amounts to about 1-3kBq/m2. The activity concentrations of 134Cs and 137Cs in soil samples from 16 sites distributed in a grid pattern over the investigated area have been measured and the depositions from the nuclear weapons tests and from the Chernobyl accident have been separated. These pre- and post-Chernobyl activities have been compared with depositions calculated from measurements of the activity concentrations of 134Cs and 137Cs in precipitation at two places and from measurements of the precipitation from a network of between 113 and 143 precipitation stations. Comparisons with in situ measurements and with aerial survey measurements have also been made. The agreement is good gain and it has been possible to gain a good and detailed knowledge in retrospect of the deposition from measurements of the deposition per mm of precipitation from just a few stations, and of the precipitation from a network of stations. Copyright (C) 2000 Elsevier Science Ltd.
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| 42. |
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| 43. |
- Isaksson, Marléne, et al.
(author)
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‘Mislabelled’ make-up remover gave facial eczema in female patients
- 2015
-
In: Forum for Nordic Dermato-Venerology. - 1402-2915. ; 20:1, s. 10-11
-
Journal article (peer-reviewed)abstract
- Incorrectly labelled cosmetic wet wipes can cause severe eczema, leading to major concerns amongst the public. Read below what was revealed by chemical analysis in a laboratory in Malmö, Sweden.
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| 44. |
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| 45. |
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| 46. |
- Isaksson, Sven, 1966-, et al.
(author)
-
Arkeologiska undersökningar av Birkas försvunna stadsvall, fornlämning L2017:1568, Raä 119:1, Svarta jorden, Björkö, Adelsö sn, Ekerö kn, Uppland, maj 2018 och maj 2019
- 2020
-
Reports (other academic/artistic)abstract
- This is a report of archaeological investigations, excavations and geochemical propections, in search for the today lost part of the town rampart of the Viking Age site Birka in eastern central Sweden, conducted by the Archaeological Research Laboratory, Stockholm University, in 2018-2019. The results show, for the first time ever, evidence of a town rampart with an associated defensive ditch in the investigated portion of the town perimeter. This is inferred to be the result of deliberate choices to build different types of defensive structures with regard to the varying terrain in different sections around Birka, indicating explicit tactical considerations when choosing construction technology.
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| 47. |
- Isaksson, Sven, 1966-, et al.
(author)
-
En vikingatida varvsplats vid Kugghamn, Birka : Arkeologiska undersökningar av L2022:2719, Birka, Björkö,Adelsö socken, Uppland, augusti 2020 och 2021
- 2022
-
Reports (other academic/artistic)abstract
- A Viking Age shipyard at Kugghamn, Birka.This is a report of an archaeological investigation of maritime remains close to and connected to the Viking Age town of Birka on Björkö, Uppland, Sweden. The investigations included surveys using GNSS receivers and drones, geochemical mapping, and the excavation of four trenches, carried out in August 2020 and August 2021. The investigations were carried out by the Archaeological Research Laboratory (AFL), Department of Archaeology and Classical Studies, Stockholm University. The results show that there was an extensive maritime cultural landscape on the northern part of Björkö, which is rich in remains of different character. One of these remains was investigated in detail by the excavation of four trenches. The feature consists of a dug-out hollow, lined with stones at sides and bottom. Evidence of a wooden contraction was found in the bottom of the hollow in the form of small post-holes, and a stone-frame at the mouth of the hollow towards the waterfront. This is interpreted as the remains of a boat slipway. Rivets, both used and unused, tools for carpentry, and slate whetstones, dominate among the finds and mirror the activities of the site. All is interpreted as evidence for a boat repair site with an associated boat slipway. Finds of e.g. glass beads contemporary with the town Birka, provides a general dating of the remains, possibly with an emphasis towards its later phases of the town. This maritime construction is a unique find with few parallels, but fits well with the other maritime remains in the area. In order to understand its function and dating, it is vital to continue investigations in this important area of Björkö.
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| 48. |
- Isaksson, Ulf, et al.
(author)
-
Validity and reliability testing of the Swedish version of Melbourne Decision Making Questionnaire
- 2014
-
In: Scandinavian Journal of Caring Sciences. - : John Wiley & Sons. - 0283-9318 .- 1471-6712. ; 28:2, s. 405-412
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The Melbourne Decision-Making Questionnaire (MDMQ) is an attempt to capture and measure coping strategies that people use. The instrument had not previously been translated into Swedish. The aim of this study was to evaluate validity and reliability of the Swedish version of the MDMQ.METHOD: A Swedish translation was performed and back-translated. A group of five pilot readers evaluated content validity. The translated questionnaire was tested among 735 patients, healthcare workers, healthcare students and teachers. A parallel analysis (PA), exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed.RESULT: An initial EFA with a four-factor solution showed a low concordance with the original 22-item four-factor model with a very low Cronbach's alpha in one of the dimensions. However, a second EFA with a three-factor solution showed a good model fit for the Swedish translation of the Melbourne Decision-Making Questionnaire (MDMQ-S) with a satisfactory Cronbach's alpha. A CFA showed a goodness of fit after deleting six items.CONCLUSION: After testing the MDMQ-S, we found support for validity and reliability of the instrument. We found the 16-item version of MDMQ-S to be satisfactory concerning the subscales vigilance, procrastination and buck-passing. However, we found no support that the hypervigilance dimension could be measured by the MDMQ-S.
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| 49. |
- Isaksson, Vincent, et al.
(author)
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The Effect of Anarchistic Actions in Digital Product Innovation Networks:The Case of “Over the Air” Software Updates
- 2017
-
In: Proceedings of the 50th Hawaii International Conference on System Sciences | 2017. - Honolulu : Hawaii International Conference on System Sciences (HICSS). - 9780998133102
-
Conference paper (peer-reviewed)abstract
- In this paper we explore mirroring challenges when an incumbent firm endeavor digital innovation. More specifically, we describe how AutoInc, organized according to the physical vehicle it produces, is challenged when an “over the air” software service is developed and implemented. Using the mirroring hypothesis as a point of departure to understand existing and emerging innovation networks, we recognize anarchistic actions. The analysis reveals the emergence of anarchic actions and how they challenge well-established federative innovation networks within the organization. With continued focus on technology, the project and organization disregarded necessary social structure development, which resulted in reduced capabilities to utilize the digitalized service. This qualitative paper also illustrates how the mirroring hypothesis, although originating from product innovation literature, can be used to understand digitalization dynamics. To the end, the analysis shows that the digital product innovation classification structure may need additional tuning.
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| 50. |
- Jahnke, Anette, 1972, et al.
(author)
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Effekter av Ifous forsknings- och utvecklingsprogram. En metastudie av sju avslutade FoU-program vid Ifous
- 2020
-
Reports (other academic/artistic)abstract
- Efter sju avslutade forsknings- och utvecklings- program (FoU-program) genomförda i samar- bete med 69 skolhuvudmän och fem lärosäten stod Ifous inför behovet av att analysera, synlig- göra och fördjupa förståelsen för det arbete som har bedrivits inom ramen för Ifous modell för FoU-samverkan. En modell som lyfts fram som ett gott exempel i en statlig utredning om praktiknära skolforskning i samverkan. Ifous, tillsammans med Stockholms stad, Nacka kommun, Kunskapsskolan och AcadeMedia, gav Anette Jahnke lektor i pedagogik, Lena Lindgren professor i offentlig förvaltning, och Simon Norman Msc i offentlig förvaltning i uppdrag att genomföra en studie av de sju avslutade FoU-programmen med syftet att synliggöra vilka effekter Ifous FoU-program ger och vilka utmaningar som finns i att nå hållbart utvecklingsarbete och användbara forskningsresultat. Tre delstudier har genomförts för att nå studiens syfte. Analys har gjorts av de 50 texter som huvudmännen författat över sitt delta- gande i FoU-programmen och som publicerats i programmens slutrapporter. Kartläggning har gjorts av de 64 vetenskapliga publikationer som producerats inom programmen. Slutligen har en metautvärdering gjorts av de externa ut värderingar som genomförts av Emerga Institute. I studien har en vidare tolkning av vad som avses med effekt använts i form av deltagarnas egna observerade förändringar.
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