| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
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| 3. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 4. |
- Drake, TM, et al.
(författare)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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| 5. |
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| 6. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 8. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 9. |
- Alvarez, E. M., et al.
(författare)
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The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet Oncology. - : Elsevier BV. - 1470-2045. ; 23:1, s. 27-52
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Tidskriftsartikel (refereegranskat)abstract
- Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 10. |
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| 11. |
- Anchordoqui, Luis A., et al.
(författare)
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The Forward Physics Facility : Sites, experiments, and physics potential
- 2022
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Ingår i: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 968, s. 1-50
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Tidskriftsartikel (refereegranskat)abstract
- The Forward Physics Facility (FPF) is a proposal to create a cavern with the space and infrastructure to support a suite of far-forward experiments at the Large Hadron Collider during the High Luminosity era. Located along the beam collision axis and shielded from the interaction point by at least 100 m of concrete and rock, the FPF will house experiments that will detect particles outside the acceptance of the existing large LHC experiments and will observe rare and exotic processes in an extremely low-background environment. In this work, we summarize the current status of plans for the FPF, including recent progress in civil engineering in identifying promising sites for the FPF and the experiments currently envisioned to realize the FPF's physics potential. We then review the many Standard Model and new physics topics that will be advanced by the FPF, including searches for long-lived particles, probes of dark matter and dark sectors, high-statistics studies of TeV neutrinos of all three flavors, aspects of perturbative and non-perturbative QCD, and high-energy astroparticle physics.
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| 12. |
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| 13. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2021
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
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Tidskriftsartikel (refereegranskat)abstract
- Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
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| 14. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 15. |
- Shaaban, Ramy, et al.
(författare)
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COVID-19 Vaccine Acceptance among Social Media Users : A Content Analysis, Multi-Continent Study
- 2022
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:9
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Tidskriftsartikel (refereegranskat)abstract
- Vaccine hesitancy (VH) is defined as a delayed in acceptance or refusal of vaccines despite availability of vaccination services. This multinational study examined user interaction with social media about COVID-19 vaccination. The study analyzed social media comments in 24 countries from five continents. In total, 5856 responses were analyzed; 83.5% of comments were from Facebook, while 16.5% were from Twitter. In Facebook, the overall vaccine acceptance was 40.3%; the lowest acceptance rates were evident in Jordan (8.5%), Oman (15.0%), Senegal (20.0%) and Morocco (20.7%) and the continental acceptance rate was the lowest in North America 22.6%. In Twitter, the overall acceptance rate was (41.5%); the lowest acceptance rate was found in Oman (14.3%), followed by USA (20.5%), and UK (23.3%) and the continental acceptance rate was the lowest in North America (20.5%), and Europe (29.7%). The differences in vaccine acceptance across countries and continents in Facebook and Twitter were statistically significant. Regarding the tone of the comments, in Facebook, countries that had the highest number of serious tone comments were Sweden (90.9%), USA (61.3%), and Thailand (58.8%). At continent level, serious comments were the highest in Asia (58.4%), followed by Africa (46.2%) and South America (46.2%). In Twitter, the highest serious tone was reported in Egypt (72.2%) while at continental level, the highest proportion of serious comments was observed in Asia (59.7%), followed by Europe (46.5%). The differences in tone across countries and continents in Facebook and Twitter and were statistically significant. There was a significant association between the tone and the position of comments. We concluded that the overall vaccine acceptance in social media was relatively low and varied across the studied countries and continents. Consequently, more in-depth studies are required to address causes of such VH and combat infodemics.
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| 16. |
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| 17. |
- Ghazy, Ramy Mohamed, et al.
(författare)
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Acceptance of COVID-19 Vaccine Booster Doses Using the Health Belief Model : A Cross-Sectional Study in Low-Middle- and High-Income Countries of the East Mediterranean Region
- 2022
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:19
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Tidskriftsartikel (refereegranskat)abstract
- Coronavirus disease (COVID-19) booster doses decrease infection transmission and disease severity. This study aimed to assess the acceptance of COVID-19 vaccine booster doses in low, middle, and high-income countries of the East Mediterranean Region (EMR) and its determinants using the health belief model (HBM). In addition, we aimed to identify the causes of booster dose rejection and the main source of information about vaccination. Using the snowball and convince sampling technique, a bilingual, self-administered, anonymous questionnaire was used to collect the data from 14 EMR countries through different social media platforms. Logistic regression analysis was used to estimate the key determinants that predict vaccination acceptance among respondents. Overall, 2327 participants responded to the questionnaire. In total, 1468 received compulsory doses of vaccination. Of them, 739 (50.3%) received booster doses and 387 (26.4%) were willing to get the COVID-19 vaccine booster doses. Vaccine booster dose acceptance rates in low, middle, and high-income countries were 73.4%, 67.9%, and 83.0%, respectively (p < 0.001). Participants who reported reliance on information about the COVID-19 vaccination from the Ministry of Health websites were more willing to accept booster doses (79.3% vs. 66.6%, p < 0.001). The leading causes behind booster dose rejection were the beliefs that booster doses have no benefit (48.35%) and have severe side effects (25.6%). Determinants of booster dose acceptance were age (odds ratio (OR) = 1.02, 95% confidence interval (CI): 1.01–1.03, p = 0.002), information provided by the Ministry of Health (OR = 3.40, 95% CI: 1.79–6.49, p = 0.015), perceived susceptibility to COVID-19 infection (OR = 1.88, 95% CI: 1.21–2.93, p = 0.005), perceived severity of COVID-19 (OR = 2.08, 95% CI: 137–3.16, p = 0.001), and perceived risk of side effects (OR = 0.25, 95% CI: 0.19–0.34, p < 0.001). Booster dose acceptance in EMR is relatively high. Interventions based on HBM may provide useful directions for policymakers to enhance the population’s acceptance of booster vaccination.
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| 18. |
- Ghazy, Ramy Mohamed, et al.
(författare)
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Quality of life among health care workers in Arab countries 2 years after COVID-19 pandemic
- 2022
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Ingår i: Frontiers in Public Health. - : Frontiers Media SA. - 2296-2565. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: Assessment of the quality of life (QoL) among healthcare workers (HCWs) is vital for better healthcare and is an essential indicator for competent health service delivery. Since the coronavirus disease 2019 (COVID-19) pandemic strike, the frontline position of HCWs subjected them to tremendous mental and psychological burden with a high risk of virus acquisition. Aim: This study evaluated the QoL and its influencing factors among HCWs residing in the Arab countries. Methods: This was a cross-sectional study using a self-administered online questionnaire based on the World Health Organization QoL-BREF instrument with additional questions related to COVID-19. The study was conducted in three different languages (Arabic, English, and French) across 19 Arab countries between February 22 and March 24, 2022. Results: A total of 3,170 HCWs were included in the survey. The majority were females (75.3%), aged 18–40 years (76.4%), urban residents (90.4%), married (54.5%), and were living in middle-income countries (72.0%). The mean scores of general health and general QoL were 3.7 ± 1.0 and 3.7 ± 0.9, respectively. Those who attained average physical, psychological, social, and environmental QoL were 40.8, 15.4, 26.2, and 22.3%, respectively. The income per capita and country income affected the mean scores of all QoL domains. Previous COVID-19 infection, having relatives who died of COVID-19, and being vaccinated against COVID-19 significantly affected the mean scores of different domains. Conclusion: A large proportion of the Arab HCWs evaluated in this study had an overall poor QoL. More attention should be directed to this vulnerable group to ensure their productivity and service provision.
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| 19. |
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| 20. |
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| 21. |
- Micah, Angela E., et al.
(författare)
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Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
- 2021
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
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Forskningsöversikt (refereegranskat)abstract
- Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 22. |
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| 23. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 24. |
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| 25. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 26. |
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A wide-band RF front-end for multiband multistandard high-linearity low-IF wireless receivers
- 2002
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Ingår i: IEEE Journal of Solid-State Circuits. - 0018-9200 .- 1558-173X. ; 37:9, s. 1162-1168
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Tidskriftsartikel (refereegranskat)abstract
- A wide-band radio-frequency (RF) front-end is designed with a balanced combined low-noise amplifier and a switching mixer (a low-noise converter) in RF Si-bipolar process with an f(T) of 25 GHz. The circuit achieves 20-dB conversion gain, higher than -4.5-dBm RF-to-IF IIP3 (+15.5-dBm OIP3) and less than 3.8-dB double-side-band noise figure in 900-MHz (e.g., GSM) and 1.9-GHz (e.g., WCDMA) frequency bands. The -1-dB compression point is -20 dBm at 13-mA dc current consumption from a single 5-V supply. The local-oscillator leakage to the input is less than -56 dBm in the 900-MHz band and less than -63 dBm in the 1.9-GHz band. The -3-dB bandwidth of the amplifier is larger than 3 GHz and a wide-band matching at the input with - 10 to -41-dB S-11 is achieved in the frequency bands of interest by applying a dual-loop wide-band active feedback. The die area is 0.69 x 0.9 mm(2). The circuit is suitable for area-efficient multiband multistandard low-IF receivers.
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| 27. |
- Abd El Ghany, M. A., et al.
(författare)
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Asynchronous BFT for low power networks on chip
- 2010
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Ingår i: ISCAS 2010 - 2010 IEEE International Symposium on Circuits and Systems. - : IEEE. - 9781424453092 ; , s. 3240-3243
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Konferensbidrag (refereegranskat)abstract
- Asynchronous Butterfly Fat Tree (BFT) architecture is proposed to achieve low power Network on Chip (NoC). Asynchronous design could reduce the power dissipation of the network if the activity factor of the data transfer between two switches (αdata satisfies a certain condition. The area of Asynchronous BFT switch is increased by 25% as compared to Synchronous switch. However, the power dissipation of the Asynchronous architecture could be decreased by up to 33% as compared to the power dissipation of the conventional Synchronous architecture when the αdata equals 0.2 and the activity factor of the control signals is equal to 1/64 of the αdata. The total metal resources required to implement Asynchronous design is decreased by 12%.
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| 28. |
- Abd El Ghany, M. A., et al.
(författare)
-
High throughput architecture for CLICHÉ network on chip
- 2009
-
Ingår i: Proceedings - IEEE International SOC Conference, SOCC 2009. - 9781424452200 ; , s. 155-158
-
Konferensbidrag (refereegranskat)abstract
- High Throughput Chip-Level Integration of Communicating Heterogeneous Elements (CLICHÉ) architecture to achieve high performance Networks on Chip (NoC) is proposed. The architecture increases the throughput of the network by 40% while preserving the average latency. The area of High Throughput CLICHÉ switch is decreased by 18% as compared to CLICHÉ switch. The total metal resources required to implement High Throughput CLICHÉ design is increased by 7% as compared to the total metal resources required to implement CLICHÉ design. The extra power consumption required to achieve the proposed architecture is 8% of the total power consumption of the CLICHÉ architecture.
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| 29. |
- Abd El Ghany, M. A., et al.
(författare)
-
High throughput architecture for high performance NoC
- 2009
-
Ingår i: ISCAS. - : IEEE. - 9781424438280 ; , s. 2241-2244
-
Konferensbidrag (refereegranskat)abstract
- High Throughput Butterfly Fat Tree (HTBFT) architecture to achieve high performance Networks on Chip (NoC) is proposed. The architecture increases the throughput of the network by 38% while preserving the average latency. The area of HTBFT switch is decreased by 18% as compared to Butterfly Fat Tree switch. The total metal resources required to implement HTBFT design is increased by 5% as compared to the total metal resources required to implement BFT design. The extra power consumption required to achieve the proposed architecture is 3% of the total power consumption of the BFT architecture.
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| 30. |
- Abd El Ghany, M. A., et al.
(författare)
-
Power characteristics of networks on chip
- 2010
-
Ingår i: ISCAS 2010 - 2010 IEEE International Symposium on Circuits and Systems. - : IEEE. - 9781424453092 ; , s. 3721-3724
-
Konferensbidrag (refereegranskat)abstract
- Power characteristics of different Network on Chip (NoC) topologies are developed. Among different NoC topologies, the Butterfly Fat Tree (BFT) dissipates the minimum power. With the advance in technology, the relative power consumption of the interconnects and the associate repeaters of the BFT decreases as compared to the power consumption of the network switches. The power dissipation of interswitch links and repeaters for BFT represents only 1% of the total power dissipation of the network. In addition of providing high throughput, the BFT is a power efficient topology for NoCs.
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| 31. |
- Abd El Ghany, M. A., et al.
(författare)
-
Power efficient networks on chip
- 2009
-
Ingår i: 2009 16th IEEE International Conference on Electronics, Circuits and Systems, ICECS 2009. - 9781424450916 ; , s. 105-108
-
Konferensbidrag (refereegranskat)abstract
- a low power switch design is proposed to achieve power-efficient Network on Chip (NoC). The proposed NoC switch reduce. The power consumption oy the Butterfly Fat Tree (BFT) architecture by 28 % as compared to the conventional BFT switch. Moreover. The power reduction technique is applied to different NoC architectures. The technique reduce. The power consumption oy the network by up to 41%. Whe. The power consumption oy the whole network includin. The interswich links and repeaters is taken into account. The overall power consumption is decreased by up to 33% at the maximum operating frequency oy the switch. The BFT architecture consume. The minimum power as compared to other NoC architectures.
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| 32. |
- Abd Elghany, M. A., et al.
(författare)
-
High throughput architecture for OCTAGON network on chip
- 2009
-
Ingår i: 2009 16th IEEE International Conference on Electronics, Circuits and Systems, ICECS 2009. - : IEEE. - 9781424450916 ; , s. 101-104
-
Konferensbidrag (refereegranskat)abstract
- High Throughput Octagon architecture to achieve high performance Networks on Chip (NoC) is proposed. The architecture increase. The throughput oy the network by 17% while preservin. The average latency. The area of High Throughput OCTAGON switch is decreased by 18% as compared to OCTAGON switch. The total metal resources required to implement High Throughput OCTAGON design is increased by 8% as compared to the total metal resources required to implement OCTAGON design. The extra power consumption required to achiev. The proposed architecture is 2% oy the total power consumption oy the OCTAGON architecture.
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| 33. |
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| 34. |
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| 35. |
- Ahmed, Sirwan Khalid, et al.
(författare)
-
Knowledge, Attitude and Worry in the Kurdistan Region of Iraq during the Mpox (Monkeypox) Outbreak in 2022 : An Online Cross-Sectional Study
- 2023
-
Ingår i: Vaccines. - : MDPI AG. - 2076-393X. ; 11:3
-
Tidskriftsartikel (refereegranskat)abstract
- The rapid spread of monkeypox (mpox) has been declared as a public health emergency of international concern (PHEIC). The present study aimed to assess the knowledge, attitude, and worry levels of the general population in the Kurdistan region of Iraq regarding the ongoing mpox multi-country outbreak. An online cross-sectional survey was conducted between 27–30 July 2022, using a convenience sampling method. The questionnaire was adapted from previous studies addressing the same topic. The independent Student’s t-test, one-way ANOVA, and logistic regression were used to assess possible factors associated with knowledge, attitude, and worry toward mpox. A total of 510 respondents were included in the final analysis. The participants showed a moderate level of mpox knowledge, a neutral attitude towards mpox, and a relatively moderate worry level. The logistic regression analysis showed that age, gender, marital status, religion, level of education, and place of residence were associated with mpox knowledge; however, the significant variables in the multivariate regression analysis were gender, religion, level of education, and residential area. Gender and residential area were associated with attitudes toward mpox; however, the significant variables in the multivariate regression analysis were gender and residential areas. The worry toward mpox was influenced by gender, marital status, religion, and place of residence, yet the significant variables in the multivariate regression analysis were gender, religion, educational level, and residential area. In conclusion, the Kurdish population had moderate knowledge, a neutral attitude, and a moderate level of worry about mpox. Considering the continuous rapid rise in mpox cases in several countries, and its possible risk as pandemic amid the ongoing COVID-19 pandemic, proactive control measures, adequate disease prevention strategies, and preparedness plans need to be formulated and immediately implemented to tackle the appearance of fears among people, and to safeguard the mental health of the public.
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| 36. |
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| 37. |
- Aktas, A., et al.
(författare)
-
Pad de-embedding in RF CMOS
- 2001
-
Ingår i: IEEE Circuits & Devices. - : Institute of Electrical and Electronics Engineers (IEEE). - 8755-3996 .- 1558-1888. ; 17:3, s. 8-11
-
Tidskriftsartikel (refereegranskat)abstract
- Welcome to The Chip! We remain committed to bringing you material you can use in your work and research. We solicit your contributions and input on what we present here. Material or short articles on chip design tips, modeling and characterization techniques, yield enhancement, packaging, and test are welcome, as well as news on new chips and start-ups, mergers, acquisitions, partnerships in the microchip business, etc. Please continue to e-mail us at ismail@ee.eng.ohio-state.edu or ntan@globespan.net. In this column, we discuss techniques for RF pad layout and de-embedding, a topic of great interest particularly for implementing radio frequency (RF) circuits in mainstream CMOS technology. Happy reading!
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| 38. |
- Alani, Mohammed M., et al.
(författare)
-
AdStop: Efficient Flow-based Mobile Adware Detection using Machine Learning
- 2022
-
Ingår i: Computers & security (Print). - : Elsevier. - 0167-4048 .- 1872-6208. ; 117
-
Tidskriftsartikel (refereegranskat)abstract
- In recent years, mobile devices have become commonly used not only for voice communications but also to play a major role in our daily activities. Accordingly, the number of mobile users and the number of mobile applications (apps) have increased exponentially. With a wide user base exceeding 2 billion users, Android is the most popular operating system worldwide, which makes it a frequent target for malicious actors. Adware is a form of malware that downloads and displays unwanted advertisements, which are often offensive and always unsolicited. This paper presents a machine learning-based system (AdStop) that detects Android adware by examining the features in the flow of network traffic. The design goals of AdStop are high accuracy, high speed, and good generalizability beyond the training dataset. A feature reduction stage was implemented to increase the accuracy of Adware detection and reduce the time overhead. The number of relevant features used in training was reduced from 79 to 13 to improve the efficiency and simplify the deployment of AdStop. In experiments, the tool had an accuracy of 98.02% with a false positive rate of 2% and a false negative rate of 1.9%. The time overhead was 5.54 s for training and 9.36 µs for a single instance in the testing phase. In tests, AdStop outperformed other methods described in the literature. It is an accurate and lightweight tool for detecting mobile adware.
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| 39. |
- Alani, Mohammed M., et al.
(författare)
-
An Intelligent Two-Layer Intrusion Detection System for the Internet of Things
- 2023
-
Ingår i: IEEE Transactions on Industrial Informatics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1551-3203 .- 1941-0050. ; 19:1, s. 683-692
-
Tidskriftsartikel (refereegranskat)abstract
- The Internet of Things (IoT) has become an enabler paradigm for different applications, such as healthcare, education, agriculture, smart homes, and recently, enterprise systems (E-IoTs). Significant advances in IoT networks have been hindered by security vulnerabilities and threats, which, if not addressed, can negatively impact the deployment and operation of IoT-enabled systems. This study addresses IoT security and presents an intelligent two-layer intrusion detection system for IoT. The system's intelligence is driven by machine learning techniques for intrusion detection, with the two-layer architecture handling flow-based and packet-based features. By selecting significant features, the time overhead is minimized without affecting detection accuracy. The uniqueness and novelty of the proposed system emerge from combining machine learning and selection modules for flow-based and packet-based features. The proposed intrusion detection works at the network layer, and hence, it is device and application transparent. In our experiments, the proposed system had an accuracy of 99.15% for packet-based features with a testing time of 0.357 μs. The flow-based classifier had an accuracy of 99.66% with a testing time of 0.410 μs. A comparison demonstrated that the proposed system outperformed other methods described in the literature. Thus, it is an accurate and lightweight tool for detecting intrusions in IoT systems.
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| 40. |
- Alani, Mohammed M., et al.
(författare)
-
PAIRED: An Explainable Lightweight Android Malware Detection System
- 2022
-
Ingår i: IEEE Access. - : Institute of Electrical and Electronics Engineers (IEEE). - 2169-3536. ; 10, s. 73214-73228
-
Tidskriftsartikel (refereegranskat)abstract
- With approximately 2 billion active devices, the Android operating system tops all other operating systems in terms of the number of devices using it. Android has gained wide popularity not only as a smartphone operating system, but also as an operating system for vehicles, tablets, smart appliances, and Internet of Things devices. Consequently, security challenges have arisen with the rapid adoption of the Android operating system. Thousands of malicious applications have been created and are being downloaded by unsuspecting users. This paper presents a lightweight Android malware detection system based on explainable machine learning. The proposed system uses the features extracted from applications to identify malicious and benign malware. The proposed system is tested, showing an accuracy exceeding 98% while maintaining its small footprint on the device. In addition, the classifier model is explained using Shapley Additive Explanation (SHAP) values.
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| 41. |
- Albrecht, Steffen, et al.
(författare)
-
A Frequency Synthesizer Architecture Using Frequency Difference Detection
- 2003
-
Konferensbidrag (refereegranskat)abstract
- In this paper, we present a frequency synthesizer architecture and its simulation results. Frequency differences are detected digitally with a high speed counter. The oscillator output frequency is used as a clock signal for the digital blocks, whereas the output frequency accuracy can be traded off with the synthesizer settling time.
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| 42. |
- Albrecht, Steffen, 1971-
(författare)
-
Sigma-delta based techniques for future multi-standard wireless radios
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Improvements in process technology and design innovations have resulted in compact and cost effective digital baseband solutions. The radio part, however, has remained a bottleneck in terms of chip area and power consumption as the feature size of analog devices does not directly benefit from scaling. With the addition of yet more standards into emerging products, the requirements of future radios will extend over characteristic performance features into demands of programmable and reconfigurable hardware for radios covering multiple frequency bands. Hence, a guideline in the design of such radios is a large degree of hardware sharing. The thesis investigates the application of sigma-delta modulation to arising multistandard wireless radios. First, it reviews principles in wireless radios, such as selected modulation and access techniques. It also examines several communication standards of personal wireless radios as well as common receiver architectures for their implementation. This is followed by general considerations and background information about sigma-delta modulators. In the third and fourth chapter, implementations to two blocks of a wireless radio receiver system are suggested: An architecture for a frequency synthesizer and an implementation of an analog-to-digital converter. In the first contribution, the thesis develops a novel concept for frequency synthesis that is more suitable for multi-band, multi-standard radio architectures, achieving a large amount of hardware sharing among different wireless standards. As a second pillar, the thesis contributes with the design of a dual-standard sigma-delta modulator for data conversion within a radio receiver. Parts of the work concerning the dual-standard modulator are embodied in a granted swedish patent.
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| 43. |
- Alzaher, H. A., et al.
(författare)
-
A CMOS fully balanced second-generation current conveyor
- 2003
-
Ingår i: IEEE transactions on circuits and systems. 2, Analog and digital signal processing (Print). - : Institute of Electrical and Electronics Engineers (IEEE). - 1057-7130 .- 1558-125X. ; 50:6, s. 278-287
-
Tidskriftsartikel (refereegranskat)abstract
- The design and implementation of a high performance CMOS fully balanced second-generation current conveyor (FBCCII) is presented. The proposed circuit is essential to extend the use of the CCII based circuits to integrated circuits (ICs) applications. The circuit is developed by applying the current sensing technique to a fully balanced version of a differential difference amplifier (DDA). A low power class AB circuit realization is implemented in a 1.2-mum CMOS technology and its different characteristics are measured. Design examples of realizing fully balanced variable gain amplifiers (VGAs) and a bandpass filter based on the proposed FBCCII are given. Experimental results of the proposed circuits are included.
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| 44. |
- Alzaher, H. A., et al.
(författare)
-
A CMOS highly linear channel-select filter for 3G multistandard integrated wireless receivers
- 2002
-
Ingår i: IEEE Journal of Solid-State Circuits. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9200 .- 1558-173X. ; 37:1, s. 27-37
-
Tidskriftsartikel (refereegranskat)abstract
- A new approach for designing digitally programmable CMOS integrated baseband filters is presented. The proposed technique provides a systematic method for designing filters exhibiting high linearity and low power. A sixth-order Butterworth low-pass filter with 14-bit bandwidth tuning range is designed for implementing the baseband channel-select filter in an integrated multistandard wireless receiver. The filter consumes a current of 2.25 mA from a 2.7-V supply and occupies an area of 1.25 mm(2) in a 0.5-mum chip. The proposed filter design achieves high spurious free dynamic ranges (SFDRs) of 92 dB for PDC (IS-54),89 dB for GSM, 84 dB for IS-95, and 80 dB for WCDMA.
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| 45. |
- Alzaher, H. A., et al.
(författare)
-
CMOS digitally programmable filter for multi-standard wireless receivers
- 2000
-
Ingår i: Electronics Letters. - : Institution of Engineering and Technology (IET). - 0013-5194 .- 1350-911X. ; 36:2, s. 133-135
-
Tidskriftsartikel (refereegranskat)abstract
- A technique for designing digitally programmable CMOS integrated filters for multi-standard wireless receivers is presented. The technique exhibits the wide frequency range of the transconductance amplifier filters while offering improved linearity. It utilises digitally controlled current followers to provide precise frequency characteristics that can be tuned over a wide range. A digitally tuned lowpass filter is designed for implementing the channel-select filter in the baseband chain of a multi-standard CMOS wireless receiver. Simulation and experimental results obtained from a 1.2 mu m chip show a programmable frequency response covering the IS-54, GSM, IS-95 and WCDMA wireless standards.
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| 46. |
- Alzaher, H., et al.
(författare)
-
A CMOS fully balanced differential difference amplifier and its applications
- 2001
-
Ingår i: IEEE transactions on circuits and systems. 2, Analog and digital signal processing (Print). - : Institute of Electrical and Electronics Engineers (IEEE). - 1057-7130 .- 1558-125X. ; 48:6, s. 614-620
-
Tidskriftsartikel (refereegranskat)abstract
- This brief presents the fully balanced version of the differential difference amplifier (DDA) as an essential building block for implementing fully differential architectures of analog CMOS integrated circuits (ICs). We demonstrate that the fully balanced differential difference amplifier (FBDDA) provides the solution for systematically developing fully differential versions of any single-ended op-amp based circuit. We also show that, unlike the DDA, the FBDDA exhibits a wide input range without demanding complex circuitry. A low-power class AB CMOS realization of the proposed circuit has been designed and fabricated in a 1.2-mum technology. All proposed design techniques and circuits were experimentally verified.
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| 47. |
- Alzaher, H., et al.
(författare)
-
A CMOS fully balanced four-terminal floating nullor
- 2002
-
Ingår i: IEEE Transactions on Circuits And Systems Part I. - : Institute of Electrical and Electronics Engineers (IEEE). - 1057-7122 .- 1558-1268. ; 49:4, s. 413-424
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents design and implementation of a CMOS fully balanced realization of the four-terminal floating nullor (FTFN). The proposed fully balanced FTFN (FBFTFN) is an essential building block for implementing fully balanced architectures of both voltage and current-mode analog CMOS integrated circuits (ICs). A low-power class AB CMOS realization of the proposed circuit is fabricated in a 1.2-mum technology. The proposed circuit has numerous applications. Several applications including fully balanced amplifiers, filters, and sinusoidal oscillators are presented. All proposed design techniques and circuits are experimentally verified.
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| 48. |
- Alzaher, H. A., et al.
(författare)
-
CMOS fully differential second-generation current conveyor
- 2000
-
Ingår i: Electronics Letters. - : Institution of Engineering and Technology (IET). - 0013-5194 .- 1350-911X. ; 36:13, s. 1095-1096
-
Tidskriftsartikel (refereegranskat)abstract
- The design of a CMOS fully differential second generation current conveyor is presented. The proposed circuit was designed to incorporate the current sensing technique into a fully differential version of a differential difference amplifier (DDA). A low power class AB circuit realisation has been implemented in 1.2 mu m CMOS technology. A variable gain amplifier (VGA) designed to incorporate the circuit has been shown to exhibit constant, low power consumption and constant, wide bandwidth at different gain settings. Experimental results of the proposed circuits are presented.
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| 49. |
- Alzaher, H. A., et al.
(författare)
-
Digitally tuned analogue integrated filters using R-2R ladder
- 2000
-
Ingår i: Electronics Letters. - : Institution of Engineering and Technology (IET). - 0013-5194 .- 1350-911X. ; 36:15, s. 1278-1280
-
Tidskriftsartikel (refereegranskat)abstract
- A new technique for designing digitally tuned frequency selective analogue integrated circuits is proposed. The technique incorporates the R-2R ladder as a circuit element into the circuit design to provide precise frequency characteristics that can be tuned over a wide range. Two filters are described to illustrate the proposed approach. The proposed filters are used to implement the channel-select filter of a multi-standard direct conversion wireless receiver and the bandpass filter of a low IF frequency-hopping receiver.
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| 50. |
- Alzaher, H., et al.
(författare)
-
CMOS baseband filter for WCDMA integrated wireless receivers
- 2000
-
Ingår i: Electronics Letters. - : Institution of Engineering and Technology (IET). - 0013-5194 .- 1350-911X. ; 36:18, s. 1515-1516
-
Tidskriftsartikel (refereegranskat)abstract
- A new second-order lowpass filter based on a single CMOS fully differential current conveyor is presented. Developed from the Sallen-Key highpass filter, the proposed filter is AC coupled and provides programmable gain. Moreover, the filter exhibits low noise, high linearity and low power, making it suitable for implementing the baseband filter of a WCDMA direct-conversion wireless receiver. A WCDMA filter having a programmable bandwidth around 2.1 MHz, a variable gain rang of 50dB and a DC notch below 2kHz using passive components below 5kW for resistors and 20pF for capacitors is implemented. Experimental and simulation results obtained from fabricated chips are included.
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