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- Nicot, A. S., et al.
(författare)
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Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
- 2007
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Ingår i: Nat Genet. - : Springer Science and Business Media LLC. ; 39:9, s. 1134-1139
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Tidskriftsartikel (refereegranskat)abstract
- Centronuclear myopathies are characterized by muscle weakness and abnormal centralization of nuclei in muscle fibers not secondary to regeneration. The severe neonatal X-linked form (myotubular myopathy) is due to mutations in the phosphoinositide phosphatase myotubularin (MTM1), whereas mutations in dynamin 2 (DNM2) have been found in some autosomal dominant cases. By direct sequencing of functional candidate genes, we identified homozygous mutations in amphiphysin 2 (BIN1) in three families with autosomal recessive inheritance. Two missense mutations affecting the BAR (Bin1/amphiphysin/RVS167) domain disrupt its membrane tubulation properties in transfected cells, and a partial truncation of the C-terminal SH3 domain abrogates the interaction with DNM2 and its recruitment to the membrane tubules. Our results suggest that mutations in BIN1 cause centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic membranes, and that the functional interaction between BIN1 and DNM2 is necessary for normal muscle function and positioning of nuclei.
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- Olsson, R., et al.
(författare)
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Experiments and analysis of laminates with artificial damage
- 2003
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Ingår i: Composites Science And Technology. - 0266-3538 .- 1879-1050. ; 63:2, s. 199-209
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Tidskriftsartikel (refereegranskat)abstract
- Quasi-isotropic carbon/epoxy laminates with holes, polymer plugs and cut fibres are studied experimentally and analytically. Strain fields are measured using digital speckle photography. The results are used to validate an inverse method, where elastic properties of inclusions are determined by matching computed and measured displacements. Tensile and compressive strength is measured and the applicability of notch failure criteria to soft inclusions is examined. Available closed form solutions agree well with measured strains. The elastic properties predicted by the inverse method are in fairly good agreement with data from coupon tests although predictions are sensitive to measuring errors. The laminate toughness in compression was higher than in tension, as expected from the di.erent failure mechanisms (fibre kinking versus fibre tearing). Laminates with inclusions were tougher than laminates with holes, which may indicate that inclusions restrain in-plane fibre kinking. Higher toughness was reflected in larger characteristic lengths. © 2002 Elsevier Science Ltd. All rights reserved.
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- Benzinger, P., et al.
(författare)
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The association between the home environment and physical activity in community-dwelling older adults
- 2014
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Ingår i: Aging clinical and experimental research. - : Springer Science and Business Media LLC. - 1720-8319. ; 26:4, s. 377-385
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Tidskriftsartikel (refereegranskat)abstract
- Physical activity (PA) decreases with increasing age despite the fact that PA exerts beneficial effects on many age-related diseases and conditions. Consequently, there is an interest in modifiable factors that may influence PA among older persons. The purpose of this study was to examine the association between PA and the home environment in wellfunctioning older community-dwelling persons. Method This study used a person-environment (P-E) fit perspective to the home environment, operationalized by means of assessment of functional limitations in 81 community- dwelling persons (median age 79 years) as well as environmental barriers in their home environments and the nearby exterior surroundings. The interaction between functional limitations and environmental barriers generated a score expressing the magnitude of P-E fit problems in their home environment. PA was rated with a questionnaire covering household-related and recreational activities. Results We found a significant association between PA and the magnitude of P-E fit problems that explained 3.9 % of the variance of PA. The number of environmental barriers per se was not significantly associated with PA, while functional limitations explained 6.8 % of the variance of PA. Conclusion In well-functioning older persons living in the community environmental aspects of housing demonstrated a weak association with PA.
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- Helle, Tina, et al.
(författare)
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Combining apps targeting professionals and senior citizens to improve housing accessibility and influence housing provision policies.
- 2015
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Ingår i: Studies in Health Technology and Informatics. - 0926-9630. - 9781614995654 ; 217, s. 300-305
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Konferensbidrag (refereegranskat)abstract
- Two separate apps that address the increasingly important issue of accessible housing for senior citizens have been developed in different project settings. One of the apps was developed to facilitate the process for professional raters to assess housing accessibility in the context of individual housing adaptations. The other app was developed for senior citizens to raise their awareness of possible accessibility problems in their current dwelling and in other apartments within the available housing stock. Both apps were developed with a high degree of active user involvement in processes utilizing multiple state of the art methods. The results are two well accepted prototype apps perceived as user-friendly and appropriate for the intended user groups. By combining these two apps, our ambition is for the professional raters to benefit by gaining knowledge of their clients' perceived needs and desires, and for senior citizens to benefit by getting access to a database of professionally rated dwellings. The ultimate goal is the generation of sound knowledge reflecting the needs and desires of senior citizens and professional requirements regarding accessible housing as a means to inform and influence housing provision policies.
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- Iwarsson, Susanne, et al.
(författare)
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On user participation in ageing research
- 2016
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Ingår i: Presented at the 23rd Nordic Congress of Gerontology (23 NKG), Tampere, Finland, June 20-22, 2016.
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Konferensbidrag (refereegranskat)
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- Offerman, J., et al.
(författare)
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Attitudes related to technology for active and healthy aging in a national multigenerational survey
- 2023
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Ingår i: Nature Aging. - : Springer. - 2662-8465. ; 3:5, s. 617-625
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Tidskriftsartikel (refereegranskat)abstract
- Research is needed to understand attitudes toward and adoption of the broad range of technologies available to support active and healthy aging in different generations. The present article gives an overview of the GenerationTech survey and sample, and describes attitudes and acceptance related to technology in general and as a means to support active and healthy aging. A national survey was conducted with a random sample (n = 2,121) including men and women from three generations (30–39, 50–59 and 70–79-year-olds) in Sweden. The generations shared some attitudes toward and acceptance of technologies for active and healthy aging. However, what kind of technologies are preferred to support active and healthy aging and the reasons for using certain technologies differed by generation. The findings could help guide the development and implementation of technologies for active and healthy aging throughout the aging process.
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| 50. |
- Ohlsson, Ann-Christine, et al.
(författare)
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Voice Therapy Outcome: A Comparison Between Imitation Model Voice Therapy and Verbal Instructions Model Voice Therapy
- 2022
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Ingår i: Journal of Voice. - : Elsevier BV. - 0892-1997.
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim was to compare voice outcomes over time in patients treated with Imitation Model voice therapy and Verbal Instructions Model voice therapy. Methods: A prospective clinical trial was performed with 56 consecutive patients diagnosed with a primary or secondary functional voice disorder. Thirty-one patients were included for voice therapy following the Imitation Model and 25 patients for the Verbal Instructions Model. Assessments included a self-rated Voice Handicap Index, self-perceived hoarseness and vocal fatigue, perceptual voice evaluation by a Speech Language Pathologist, and maximum Voice Range Profiles. All assessments were completed before therapy, at end of therapy, at six-months posttherapy follow-up and 12-months posttherapy follow-up. For maximum Voice Range Profiles group differences were also compared for effects from end-of-treatment to follow-up assessments. Linear mixed models were used for analysis. Results: Comparison between treatment groups showed significantly larger long-term improvement from the baseline, for verbal instructions model as compared to imitation model for Voice Handicap Index total, and also the physical and emotional subscales, while there was no difference between groups for the functional subscale. Also, voice quality improved more after verbal instructions model, as compared to imitation model, at end of therapy. Results from self-rated hoarseness and vocal fatigue showed no difference between groups. There was no difference between treatment groups in the change of maximum Voice Range Profile from end-of-treatment to follow-up assessments. Conclusions: The study showed that both Imitation Model voice therapy and Verbal Instructions Model voice therapy improved voice function. Compared to Imitation Model, the Verbal Instructions model showed larger long-term effect on physical and emotional aspects of voice function in everyday life. The two approaches for voice therapy might have different impacts on patients’ learning. © 2022 The Voice Foundation
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