| 1. |
- Jönsson, Maria, 1977-, et al.
(författare)
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FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor Fox03
- 2004
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Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 318:4, s. 899-903
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Tidskriftsartikel (refereegranskat)abstract
- Proliferation, differentiation, and survival of hematopoietic cells are regulated by cytokines, acting through specific receptors. FLT3 ligand (FL) is one of the most important cytokines for regulation of the hematopoietic system, and its receptor FLT3 is expressed on both stem cells and progenitors. Regulation of Forkhead transcription factors has been described as an important mechanism to control apoptosis and cell cycle progression in hematopoietic progenitors. Here we report that FL induces AKT/PKB activation, which in turn phosphorylates and thereby inactivates the Forkhead protein FoxO3 in the progenitor cell line FDC-P1 stably expressing murine FLT3 receptor. Phosphorylation of AKT and FoxO3 was blocked by the PI-3 kinase inhibitor LY294002 but not by the MAP kinase inhibitor PD98059. Expression of a mutated FoxO3, in which all three inhibitory phosphorylation sites were mutated to alanine, led to rapid increase of apoptotic cells in the presence of FL. These results suggest that FL-induced regulation of apoptosis is executed by FoxO3. (C) 2004 Elsevier Inc. All rights reserved.
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| 2. |
- Santini, Marina, et al.
(författare)
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Designing an Extensible Domain-Specific Web Corpus for “Layfication” : A Case Study in eCare at Home
- 2019
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Ingår i: Cyber-Physical Systems for Social Applications. - Hershey, PA, USA : IGI Global. - 9781522593454 - 9781522578802 ; , s. 98-155
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Bokkapitel (refereegranskat)abstract
- In the era of data-driven science, corpus-based language technology is an essential part of cyber physical systems. In this chapter, the authors describe the design and the development of an extensible domain-specific web corpus to be used in a distributed social application for the care of the elderly at home. The domain of interest is the medical field of chronic diseases. The corpus is conceived as a flexible and extensible textual resource, where additional documents and additional languages will be appended over time. The main purpose of the corpus is to be used for building and training language technology applications for the “layfication” of the specialized medical jargon. “Layfication” refers to the automatic identification of more intuitive linguistic expressions that can help laypeople (e.g., patients, family caregivers, and home care aides) understand medical terms, which often appear opaque. Exploratory experiments are presented and discussed.
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| 3. |
- Appelgren, Ester, 1977-, et al.
(författare)
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Engaging Citizens for Climate Change : Challenges for Journalism
- 2021
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Ingår i: Digital Journalism. - : Taylor & Francis. - 2167-0811 .- 2167-082X. ; :6, s. 755-772
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Tidskriftsartikel (refereegranskat)abstract
- How issues are framed in journalism in terms of problems, solutions, and levels of responsibility is of great importance in order to engage and lead toward individual and collective action. Data journalism has been acknowledged as a practice that often features a high level of interactivity, with the potential to engage the public. In this study, we investigate the content and production of climate change reporting in Swedish public service data journalism and discuss how frames are used in this alternative form of moderated science communication. Our results indicate an unconventional merger between science communication and data journalistic practices where motivational framing is used only to some extent as a way to increase public engagement with climate change. We also found that producers focus on educating and raising awareness rather than engaging the public and that they are guided by the ideal of objectivity.
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| 4. |
- Loutfi, Amy, 1978-, et al.
(författare)
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Ecare@home : A distributed research environment on semantic interoperability
- 2016
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Ingår i: Lect. Notes Inst. Comput. Sci. Soc. Informatics Telecommun. Eng.. - Cham : Springer International Publishing. - 9783319512334 - 9783319512341 ; , s. 3-8
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Konferensbidrag (refereegranskat)abstract
- This paper presents the motivation and challenges to developing semantic interoperability for an internet of things network that is used in the context of home based care. The paper describes a research environment which examines these challenges and illustrates the motivation through a scenario whereby a network of devices in the home is used to provide high-level information about elderly patients by leveraging from techniques in context awareness, automated reasoning, and configuration planning.
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| 5. |
- Santini, Marina, 1960-, et al.
(författare)
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Designing an Extensible Domain-Specific Web Corpus for “Layfication” : A Case Study in eCare at Home : Chapter 6
- 2019
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Ingår i: Cyber-Physical Systemsfor Social Applications. - Hershey PA, USA 17033 : Engineering Science Reference. - 9781522578796 - 9781522578802 ; , s. 98-155
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In the era of data-driven science, corpus-based language technology is an essential part of cyber physicalsystems. In this chapter, the authors describe the design and the development of an extensible domainspecificweb corpus to be used in a distributed social application for the care of the elderly at home.The domain of interest is the medical field of chronic diseases. The corpus is conceived as a flexible andextensible textual resource, where additional documents and additional languages will be appendedover time. The main purpose of the corpus is to be used for building and training language technologyapplications for the “layfication” of the specialized medical jargon. “Layfication” refers to the automaticidentification of more intuitive linguistic expressions that can help laypeople (e.g., patients, familycaregivers, and home care aides) understand medical terms, which often appear opaque. Exploratoryexperiments are presented and discussed.
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| 6. |
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