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Sökning: WFRF:(Jagoda E)

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  • Douglas, Timothy E. L., et al. (författare)
  • Pectin coatings on titanium alloy scaffolds produced by additive manufacturing : Promotion of human bone marrow stromal cell proliferation
  • 2018
  • Ingår i: Materials letters (General ed.). - : Elsevier BV. - 0167-577X .- 1873-4979. ; 227, s. 225-228
  • Tidskriftsartikel (refereegranskat)abstract
    • Ti6Al4V is a popular biomaterial for load-bearing implants for bone contact, which can be fabricated by additive manufacturing technologies. Their long-term success depends on their stable anchoring in surrounding bone, which in turn depends on formation of new bone tissue on the implant surface, for which adhesion and proliferation of bone-forming cells is a pre-requisite. Hence, surface coatings which promote cell adhesion and proliferation are desirable. Here, Ti6Al4V discs prepared by additive manufacturing (EBM) were coated with layers of pectins, calcium-binding polysaccharides derived from citrus (C) and apple (A), which also contained alkaline phosphatase (ALP), the enzyme responsible for mineralization of bone tissue. Adhesion and proliferation of human bone marrow stromal cells (hBMSC) were assessed. Proliferation after 7 days was increased by A-ALP coatings and, in particular, by C-ALP coatings. Cell morphology was similar on coated and uncoated samples. In conclusion, ALP-loaded pectin coatings promote hBMSC adhesion and proliferation. 
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  • Lund, Mikael, et al. (författare)
  • Dielectric Interpretation of Specificity of Ion Pairing in Water
  • 2010
  • Ingår i: The Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 1:1, s. 300-303
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a dielectric continuum model that, at a semiquantitative level, explains why ion pair formation in water is favored by like-sized ions over unlike-sized pairs. Using both classical and ab initio continuum approaches, we show that the now well-established empirical rule, the so-called “law of matching water affinities”, can be rationalized in terms of ion solvation. Namely, pairing of differently sized ions is weakened due to a shadowing effect where the larger ion shields the smaller ion from the solvent. It is shown that this empirical law ceases to be valid for less polar solvents where strong ion−ion coulomb interactions dominate the pairing free energy. The presented model demonstrates that certain ion-specific effects, such as those connected with the Hofmeister series, can be qualitatively captured by classical continuum electrostatics, although a fully quantitative description would require explicit molecular treatment of the solvent.
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  • Resultat 1-4 av 4

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