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- Kanai, M, et al.
(författare)
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- 2023
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- Thomas, HS, et al.
(författare)
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- 2019
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- Niemi, MEK, et al.
(författare)
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- 2021
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- Sen, P, et al.
(författare)
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Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys
- 2023
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Ingår i: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 62:10, s. 3291-3301
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveCOVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys.MethodsThe first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups.ResultsWe analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs – OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs – OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7–10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8–0.97)].ConclusionVaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.
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| 44. |
- Singhal, Pranshu, et al.
(författare)
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Snow and glacier melt in the Satluj River at Bhakra Dam in the western Himalayan region
- 2002
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Ingår i: Hydrological Sciences Journal. - 0262-6667. ; 47:1, s. 93-106
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Tidskriftsartikel (refereegranskat)abstract
- Streamflow in the Himalayan rivers is generated from rainfall, snow and ice. The distribution of runoff produced from these sources is such that the streamflow may be observed in these rivers throughout the year, i.e. they are perennial in nature. Snow and glacier melt runoff contributes substantially to the annual flows of these rivers and its estimation is required for the planning, development and management of the water resources of this region. The average contribution of snow and glacier melt runoff in die annual flows of the Satluj River at Bhakra Dam has been determined. Keeping in view the availability of data for the study basin, a water balance approach was used and a water budget period of 10 years (October 1986-September 1996) was considered for the analysis. The rainfall input to the study basin over the water budget period was computed from isohyets using rainfall data of 10 stations located at different elevations in the basin. The total volume of flow for the same period was computed using observed flow data of the Satluj River at Bhakra Darn. A relationship between temperature and evaporation was developed and used to estimate the evapotranspiration losses. The snow-covered area, and its depletion with time, was determined using satellite data. It was found that the average contribution of snow and glacier runoff in the annual flow of the Satluj River at Bhakra Dam is about 59%, the remaining 41% being from rain.
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| 45. |
- Zulkifli, M, et al.
(författare)
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Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4866-
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondrial calcium uniporter (MCU), a multi-protein complex whose assembly in the inner mitochondrial membrane is facilitated by the scaffold factor MCUR1. Intriguingly, many fungi that lack MCU contain MCUR1 homologs, suggesting alternate functions. Herein, we characterize Saccharomyces cerevisiae homologs Put6 and Put7 of MCUR1 as regulators of mitochondrial proline metabolism. Put6 and Put7 are tethered to the inner mitochondrial membrane in a large hetero-oligomeric complex, whose abundance is regulated by proline. Loss of this complex perturbs mitochondrial proline homeostasis and cellular redox balance. Yeast cells lacking either Put6 or Put7 exhibit a pronounced defect in proline utilization, which can be corrected by the heterologous expression of human MCUR1. Our work uncovers an unexpected role of MCUR1 homologs in mitochondrial proline metabolism.
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| 46. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 47. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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