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1.	Dorschel, Boris, et al. (författare) The International Bathymetric Chart of the Southern Ocean Version 2 2022 Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 9:1 Tidskriftsartikel (refereegranskat)abstract The Southern Ocean surrounding Antarctica is a region that is key to a range of climatic and oceanographic processes with worldwide effects, and is characterised by high biological productivity and biodiversity. Since 2013, the International Bathymetric Chart of the Southern Ocean (IBCSO) has represented the most comprehensive compilation of bathymetry for the Southern Ocean south of 60 degrees S. Recently, the IBCSO Project has combined its efforts with the Nippon Foundation - GEBCO Seabed 2030 Project supporting the goal of mapping the world's oceans by 2030. New datasets initiated a second version of IBCSO (IBCSO v2). This version extends to 50 degrees S (covering approximately 2.4 times the area of seafloor of the previous version) including the gateways of the Antarctic Circumpolar Current and the Antarctic circumpolar frontal systems. Due to increased (multibeam) data coverage, IBCSO v2 significantly improves the overall representation of the Southern Ocean seafloor and resolves many submarine landforms in more detail. This makes IBCSO v2 the most authoritative seafloor map of the area south of 50 degrees S.
2.	Drott, Jenny, et al. (författare) Factors related to a successful professional development for specialist nurses in surgical care: a cross-sectional study 2023 Ingår i: BMC Nursing. - : Springer Science and Business Media LLC. - 1472-6955. ; 22:1 Tidskriftsartikel (refereegranskat)abstract BackgroundA high level of competence among staff is necessary for providing patient-safe surgical care. Knowledge regarding what factors contribute to the professional development of specialist nurses in surgical care and why they choose to remain in the workplace despite high work requirements is needed. To investigate and describe the organizational and social work environment of specialist nurses in surgical care as part of studying factors that impact on professional development.MethodThis was a cross-sectional study with a strategic convenience sampling procedure that recruited 73 specialist nurses in surgical care in Sweden between October to December 2021. The study was guided by STROBE Statement and checklist of cross-sectional studies. The validated Copenhagen Psychosocial Questionnaire was used, and additional demographic data. Descriptive statistics were performed and the comparison to the population benchmarks was presented as the mean with a 95% confidence interval. To study potential differences among the demographic and professional characteristics, pairwise t tests were used with Bonferroni adjustment for multiple comparisons with a significance level of 5%.ResultsFive domains were identified as factors related to success, as they received higher scores in relation to population benchmarks: quality of leadership, variation of work, meaning of work and work engagement as well as job insecurity. There was also a significant association between a having a manager with low nursing education and job insecurity (p = 0.021).ConclusionsQuality of leadership is important for the professional development of specialist nurses in surgical care. Strategic work seems to include managers with a higher nursing education level to prevent insecure professional working conditions.
3.	Jakobsson, J., et al. (författare) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Tidskriftsartikel (refereegranskat)
4.	Jakobsson, Jenny, 1975-, et al. (författare) Work conditions influencing professional development of specialist nurses in surgical care explored using the Job Demand-Resources theory: A qualitative study 2023 Ingår i: Journal of Advanced Nursing. - : Wiley. - 0309-2402 .- 1365-2648. ; 79:7, s. 2610-2621 Tidskriftsartikel (refereegranskat)abstract Aim:The aim of the study was to explore the work conditions that influence the opportunities for professional development of specialist nurses in surgical care. Design:A qualitative descriptive design was used. Methods:With a purposeful sampling procedure, 14 specialist nurses in surgical care were included. Four focus-group interviews were conducted during November to December 2021 and deductively analysed using the Job Demand-Resource theory as a guiding framework. Reporting adheres to COREQ guidelines. Findings:Work conditions that were identified as job demands and that inhibited nurses' opportunities for professional development were mainly found at an organizational and leadership level. Primarily, those conditions included role ambiguity and time constraints caused by uncompensated nursing shortages that restricted the nurses from exercising their role. Such conditions could also discourage other nurses from further education. Job demands were seen as largely compensated for by work conditions identified as job resources and located mainly at an individual level, for example finding the work interesting and multifaceted. Most prominent was the participants' inner motivation to work with surgical patients and to continue to develop themselves and other nurses professionally. Conclusions:A prerequisite for professional development is that the specialist role is clearly defined in collaboration with representatives from the nursing profession and universities. Hence, hospital organizations need to reflect on how to utilize the competence. Also, it is important that nurse leaders promote the specialist nurses' motivation by supporting them in the exercise of their role. Impact:Findings from this study revealed work conditions that need to be acknowledged during hospital organizations' endeavours to maintain and enhance nursing competence. Patient or Public Contribution:Patient or public contribution was not applicable since the study focused on specialist nurses' working conditions.
5.	Aho, Anna Carin, et al. (författare) Experiences of Playing Volt Hockey With Focus on Well-Being According to Positive Emotion, Engagement, Relationships, Meaning, Achievement : An Interview Study 2022 Ingår i: Adapted Physical Activity Quarterly. - : Human Kinetics. - 0736-5829 .- 1543-2777. ; 39:2, s. 160-178 Tidskriftsartikel (refereegranskat)abstract Volt hockey is a team sport developed for persons with physical disabilities, but its influence on well-being is unknown. Elements of well-being have been described as positive emotions, engagement, relationships, meaning, and achievement constituting a theoretical framework referred to as PERMA. The purpose of this study was to describe how well-being according to PERMA is reflected in the experiences of playing volt hockey. Data were collected through focus group and individual interviews including 21 players. A deductive analysis was conducted using the elements in PERMA as preexisting main categories with an additional main category, named resources needed. Findings showed that all five elements constituting well-being according to PERMA were reflected in the experiences of playing volt hockey. In addition, players emphasized the importance of having the resources needed to play volt hockey. In conclusion, having the opportunity to enjoy playing volt hockey enabled the players to flourish and experience feelings of subjective well-being.
6.	Aho, Anna Carin, et al. (författare) Experiences of volt hockey from family members’ perspectives : an interview study 2024 Ingår i: Sport in Society. - : Routledge. - 1743-0437 .- 1743-0445. ; , s. 1-14 Tidskriftsartikel (refereegranskat)abstract Volt hockey is a team sport developed for persons with physical disabilities. Because family members are important resources to enable sports participation, the purpose of this study was to illuminate experiences of volt hockey from family members’ perspectives. Focus group interviews were conducted, including 20 family members, and the verbatim transcripts were inductively analysed using reflexive thematic analysis. Family members saw the value of enabling participation in volt hockey, being an inclusive team sport that brings enjoyment and strengthens social relationships within, and outside of, the family. Trying to facilitate sport participation, the need for material resources and other actors was emphasised, such as personal assistance, funders, and healthcare professionals informing about the sport and the engagement of the volt hockey clubs. In conclusion, involvement in volt hockey is emotionally and socially rewarding for family members, but there is a need for additional enablers to allow the sport to grow.
7.	Andersson, Jenny, et al. (författare) Decision‐Making in Seeking Emergency Care for Stroke Symptoms 2022 Ingår i: Stroke: Vascular and Interventional Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 2694-5746. ; 2:6 Tidskriftsartikel (refereegranskat)abstract BackgroundPrevious studies have shown that rapid treatment for stroke, especially ischemic stroke, reduces mortality and disability. The focus has mainly been on reducing time from arrival at hospital to start of treatment. However, the main reason for delay is often time from symptom onset to arrival at hospital. This study therefore aimed to explore decision‐making processes after the onset of stroke symptoms in patients experiencing a first‐time stroke.MethodsWe included 36 patients aged 18 and older, all of whom were hospitalized with a first‐time stroke between October 2018 and April 2020. All patients were interviewed once within 4 weeks of symptom onset and before hospital discharge. Eligible patients were identified retrospectively through a targeted review of medical records. The data were collected and analyzed according to the grounded theory methodology.ResultsIn total, 43 potential patients were identified and asked to participate. Overall, 36 patients were included in the study: 17 women (median age 77.0 years, interquartile range 17.5) and 19 men (median age 65.7 years, interquartile range 17.2). All interviewees felt fear, and this affected their decision to seek emergency care. The decision‐making processes were described by the core category of “Acting on fear.” The reason for feeling frightened determined the actions taken. The reasons were sorted into 3 main categories: (1) “seeking care”–recognized stroke symptoms and acted immediately; (2) “pending and reluctance”–suspected stroke but awaited to seek care; and (3) “seeking an explanation”–confused by symptoms.ConclusionWe found that decision‐making when experiencing stroke symptoms was complex. All patients felt fear, which determined their actions. Some patients knew about stroke symptoms and acted immediately. Others suspected stroke but still chose to wait, whereas others were confused and tried to find answers. These results could contribute to form future awareness campaigns.
8.	Andersson, Jenny, et al. (författare) Patient´s description of onset stroke symptoms : Oral Presentations. ESOC 2023 Abstract Book 2023 Ingår i: European Stroke Journal. - : Sage Publications. - 2396-9873 .- 2396-9881. ; 8:2, s. 427-427 Tidskriftsartikel (refereegranskat)abstract Background and aims: Stroke symptoms vary and could be hard to recognize. In addition, stroke severity has decreased according to the National Institutes of Health Stroke Scale (NISSH), with less pronounced symptoms expression. Knowledge on the patient’s description of stroke symptoms is therefore needed. The aim was to describe patient’s symptoms at stroke onset.Methods: A qualitative content analysis was used. Data were collected through individual interviews with 27 patients (16 men and 11 women, median age 70.4 years). All patients were hospitalized with a first-time stroke. The interviews were conducted within 4 weeks of symptoms onset and before hospital discharge.Results: All patients had symptoms that affected their daily life. Some patients described having multiple symptoms at the same time, others had symptoms that began insidiously and worsened over time. Symptoms such as overwhelming fatigue or nausea were described as Premonition of becoming ill, feeling unwell or that something was wrong. Motoric bodily changes were multifaceted as slurred speech or dizziness, balance difficulties and losing control of the body or motor dysfunction. But also, that the surroundings were distorted, and solid objects moved around. Symptoms of Dazed and affected senses included confusion and visual impairment or headache.Conclusions: Stroke is a complex disease with several different symptoms’ expressions and could be difficult to recognize, especially when symptoms are less typical or perceived as not serious. Increased awareness of stroke symptoms among caregivers and among members of the community is important and needed.
9.	Andersson, Jenny, et al. (författare) Symptoms at stroke onset as described by patients: a qualitative study 2024 Ingår i: BMC Neurology. - : Springer Nature. - 1471-2377. ; 24:1 Tidskriftsartikel (refereegranskat)abstract Background: Stroke is a common and severe disease that requires prompt care. Symptom expressions as one-sidedweakness and speech difficulties are common and included in public stroke campaigns. For some patients stroke canpresent with subtle and less common symptoms, difficult to interpret. The symptom severity assessed by the NationalInstitutes of Health Stroke Scale has decreased, and symptoms at onset may have changed. Therefore, we aimed toinvestigate how patients describe their symptoms at the onset of a first-time stroke.Methods:The study used a qualitative descriptive design and conventional content analysis. Data were collectedthrough recorded interviews with 27 patients aged 18 years and older hospitalised with a first-time stroke betweenOctober 2018 and April 2020. Data were analysed on a manifest level.Results: Symptoms at stroke onset were presented in two themes: Altered Reality and Discomfort and Changed BodyFunctions and described in five categories. Various types of symptoms were found. All symptoms were perceivedas sudden, persistent, and never experienced before and this appear as a “red thread” in the result. Regardless ofsymptom expressions, no specific symptom was described as more severe than another.Conclusions: Stroke symptoms were described with a variety of expressions. Many described complex symptomsnot typical of stroke, which can make it difficult to recognise the symptoms as a stroke and delay medical care. Publicstroke campaigns should emphasize the importance of seeking medical care at the slightest suspicion of stroke andcould be designed to help achieve this.
10.	Arndt, Jan Erik, et al. (författare) The International Bathymetric Chart of the Southern Ocean (IBCSO) Version 1.0-A new bathymetric compilation covering circum-Antarctic waters 2013 Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 40:12, s. 3111-3117 Tidskriftsartikel (refereegranskat)abstract The International Bathymetric Chart of the Southern Ocean (IBCSO) Version 1.0 is a new digital bathymetric model (DBM) portraying the seafloor of the circum-Antarctic waters south of 60 degrees S. IBCSO is a regional mapping project of the General Bathymetric Chart of the Oceans (GEBCO). The IBCSO Version 1.0 DBM has been compiled from all available bathymetric data collectively gathered by more than 30 institutions from 15 countries. These data include multibeam and single-beam echo soundings, digitized depths from nautical charts, regional bathymetric gridded compilations, and predicted bathymetry. Specific gridding techniques were applied to compile the DBM from the bathymetric data of different origin, spatial distribution, resolution, and quality. The IBCSO Version 1.0 DBM has a resolution of 500 x 500 m, based on a polar stereographic projection, and is publicly available together with a digital chart for printing from the project website (www.ibcso.org) and at .
11.	Aronsson, Håkan, et al. (författare) Anmälningar till socialtjänsten om barn och unga : En undersökning om omfattning och regionala skilnnader 2012 Rapport (övrigt vetenskapligt/konstnärligt)
12.	Axelsson, Malin, 1964-, et al. (författare) Translation and validation of the Swedish version of the IPECC-SET 9 item version 2022 Ingår i: Journal of Interprofessional Care. - : Taylor & Francis. - 1356-1820 .- 1469-9567. ; 36:6, s. 900-907 Tidskriftsartikel (refereegranskat)abstract Interprofessional Education (IPE) is essential to prepare future health-care professionals for collaborative practice, but IPE requires evaluation. One psychometrically sound instrument is the Interprofessional Education Collaborative Competence Self-Efficacy Tool consisting of nine items (IPECC-SET 9). This tool does not, to date, exist in a Swedish version. Therefore, the aim of this study was to translate and validate the Swedish version of the IPECC-SET 9. The English version was translated into Swedish and tested among 159 students in the 3-year Bachelor Programs in Nursing and in Biomedical Laboratory Science. The psychometric analysis was guided by a Rasch model, which showed that the items functioned well together, confirming unidimensionality, and that the person misfit was also lower than the set criterion. The separation index was 2.98, and the Rasch-equivalent Cronbach-alpha measure was estimated to .92, supporting internal consistency. No systematic differences on item level in IPECC-SET 9 further supported fairness in testing. The Swedish IPECC-SET 9 demonstrates sound psychometric properties and has the potential to be used as a measure of self-efficacy for competence in interprofessional collaborative practice among health profession students. However, the IPECC-SET 9 is recommended to be further tested in larger samples representing the entirety of health-care teams.
13.	Axelsson, Malin, et al. (författare) Which nursing students are more ready for interprofessional learning? A cross-sectional study 2019 Ingår i: Nurse Education Today. - : Elsevier. - 0260-6917 .- 1532-2793. ; 79, s. 117-123 Tidskriftsartikel (refereegranskat)abstract Background: It has been argued that the significance of personality in relation to students' readiness for interprofessional collaboration is an area where more research is needed. Nursing students in particular seem to be unsure about their role in the interprofessional team. Objective: To explore associations between nursing students' readiness for interprofessional learning and personality traits with regard to biological sex, and previous work experience from health care. Design: A cross-sectional questionnaire study. Setting: Nursing students in year one and three enrolled in a three-year undergraduate bachelor in nursing programme. Participants: Nursing students (n = 284) in semester two and six. Methods: The participants completed the Readiness for Interprofessional Learning Scale and the Neuroticism, Extraversion, and Openness to experience Five Factor Inventory-3. The data were statistically analyzed by descriptive statistics, t-tests, correlations and linear regressions. Results: Four of the five investigated personality traits – Extraversion, Openness to experiences, Agreeableness and Conscientiousness - were associated with nursing students' readiness for interprofessional learning. Moreover, nursing students in semester six were more ready for interprofessional learning regarding Negative professional identity and Roles and responsibilities than students in semester two. Female students were more ready for Teamwork and collaboration than male students. Conclusions: Nursing students being more outgoing, open-minded, agreeable or conscientious seem to be more ready for interprofessional learning. Consequently, personality is of significance for nursing students' readiness for interprofessional learning.
14.	Berg, L., et al. (författare) Characterizing the effects of epigenetic regulation in assays using peripheral blood mononuclear cells from patients with inflammatory diseases 2016 Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 45, s. 44-45 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
15.	Björkman, Ida, et al. (författare) An Intervention for Person-Centered Support in Irritable Bowel Syndrome Development and Pilot Study 2019 Ingår i: Gastroenterology Nursing. - : Ovid Technologies (Wolters Kluwer Health). - 1042-895X. ; 42:4, s. 332-341 Tidskriftsartikel (refereegranskat)abstract Irritable bowel syndrome is a common and often chronic functional bowel disorder that can cause severe disruption of daily functioning in those affected, with subsequent high healthcare utilization and work absenteeism. Nurses represent an underutilized group in the current management of irritable bowel syndrome. The aim of this study was to systematically develop a person-centered support intervention in irritable bowel syndrome and evaluate this in a pilot study. The development followed the revised framework for complex interventions from the Medical Research Council and involved literature reviews and multiprofessional expert groups. The intervention was then tested in a pilot study including 17 patients and evaluated through validated questionnaires measuring irritable bowel syndrome symptom severity, gastrointestinal-specific anxiety, and self-efficacy as well as through interviews. There was a significant improvement in irritable bowel syndrome symptom severity between baseline and follow-up, but not for self-efficacy or gastrointestinal-specific anxiety. The patients' perceptions of participating in the intervention were positive and induced a learning process; they were able to form a supportive relationship with the nurse and their ability to self-manage improved. The promising results from this small pilot study in terms of feasibility, potential efficacy, and the patients' positive feedback make this intervention a suitable candidate for a larger controlled trial.
16.	Bourdieu, Pierre, et al. (författare) Leve idrottspedagogiken : En vänbok tillägnad Lars-Magnus Engström 2005 Bok (övrigt vetenskapligt/konstnärligt)abstract Vem ägnar sig åt idrott? Vilken betydelse har fritiden i barns och ungdomars liv? Vad innebär hälsa i skolämnet idrott och hälsa?Leve idrottspedagogiken! tillägnas Lars-Magnus Engström. Texterna i boken speglar delar av det idrottspedagogiska forskningsområdet i Sverige, vars framväxt Lars-Magnus Engström varit den främste företrädaren för. Läsaren får här ta del av exempelvis idrottskulturen, fritidskulturen och skolans ämne idrott och hälsa. Genomgående handlar texterna om villkoren för barns och ungdomars deltagane och om de olika lärprocesser som sker i anslutning till idrottsutövning.Lars-Magnus Engström har gjort betydande insatser som forskare och lärare samt som professor vid Lärarhögskolan i Stockholm och vid Gymnastik- och idrottshögskolan. I snart fyrtion år har han arbetat med studier kring påverkans- och lärprocesser i idrott. Hans forskning har främst kretsat kring människors idrottsvanor och vilka som utvecklar en fysiskt aktiv livsstil. Idrotts- och motionsutövningar ger både ett så kallat egenvärde och investeringsvärde. Med dessa begrepp bland många andra har Lars-Magnus Engström bidragit till en fördjupad vetenskaplig förståelse av idrottskulturen.De flesta författarna har eller har haft Lars-Magnus Engström som handledare och tillhör forskningsgruppen för pedagogik, idrott och fritidskultur. Redaktörer för boken är Karin Redelius och Håkan Larsson.
17.	Brattås, Per Ludvik, et al. (författare) TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells 2017 Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 18:1, s. 1-11 Tidskriftsartikel (refereegranskat)abstract Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.
18.	Ekholm, Jan, et al. (författare) Hinder och framgångsfaktorer i rehabiliteringsprocessen : En sammanfattning baserad på kvantitativa och kvalitativa studier av faktorerer eller företeelser associerade med långtidsjukskrivnas återkomst i arbete 2002 Rapport (övrigt vetenskapligt/konstnärligt)
19.	Ekström, Ulf, et al. (författare) Insufficient mixing of thawed serum samples leading to erroneous results - experience from a field study and use of a correction procedure 2020 Ingår i: Scandinavian Journal of Clinical & Laboratory Investigation. - : Informa UK Limited. - 0036-5513 .- 1502-7686. ; 80:2, s. 99-105 Tidskriftsartikel (refereegranskat)abstract Incorrect analysis results that are close to expected might not be recognized in scientific studies or routine patient care. In two field studies we obtained unexpected results in a large number of samples. The present study aimed to identify the source of error in the samples from these studies and to validate a method to obtain correct results. Pre-analytical procedures were scrutinized, giving no indications of inappropriate pre-analytical sample handling in the field or during transport in a tropical climate. Using a new set of samples from volunteers in simulation experiments, we observed the known concentration gradient of analytes sampled in gel as well as plain tubes after freezer storage and thawing. Experiments demonstrated that mixing of samples by vortexing alone was not sufficient to disrupt the gradient formed by freezing and thawing, which appeared to cause the problem encountered when we in field studies analyzed and biobanked large sample sets by robot pipetting. A correction procedure was introduced, in which the obtained value of an analyte was multiplied by a correction factor calculated for each sample using the expected sodium level (140 mmol/L) divided by the measured sodium value. When it was validated on results from the simulation experiments, we repeatedly found that the correction lead to results very close to true values for analytes of different size and charge. Usefulness of the procedure was demonstrated when applied to a large set of field study results.
20.	Eriksson, Anna-Lena, 1971, et al. (författare) SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. 2006 Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 91:12, s. 5029-37 Tidskriftsartikel (refereegranskat)abstract CONTEXT: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. OBJECTIVE: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n) microsatellite and rs1799941 single-nucleotide polymorphism] are associated with serum levels of SHBG, sex steroids, or bone mineral density (BMD) in men. DESIGN AND STUDY SUBJECTS: We conducted a population-based study of two cohorts of Swedish men: elderly men (MrOS Sweden; n congruent with 3000; average age, 75.4 yr) and young adult men (GOOD study; n = 1068; average age, 18.9 yr). MAIN OUTCOME MEASURES: We measured serum levels of SHBG, testosterone, estradiol, dihydrotestosterone, 5alpha-androstane-3alpha,17beta-diol glucuronides, androsterone glucuronide, and BMD determined by dual-energy x-ray absorptiometry. RESULTS: In both cohorts, (TAAAA)(n) and rs1799941 genotypes were associated with serum levels of SHBG (P < 0.001), dihydrotestosterone (P < 0.05), and 5alpha-androstane-3alpha,17beta-diol glucuronides (P < 0.05). In the elderly men, they were also associated with testosterone and BMD at all hip bone sites. The genotype associated with high levels of SHBG was also associated with high BMD. Interestingly, male mice overexpressing human SHBG had increased cortical bone mineral content in the femur, suggesting that elevated SHBG levels may cause increased bone mass. CONCLUSIONS: Our findings demonstrate that polymorphisms in the SHBG promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men.
21.	Glaser, J., et al. (författare) Preventing kidney injury among sugarcane workers: Promising evidence from enhanced workplace interventions 2020 Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 77:8, s. 527-534 Tidskriftsartikel (refereegranskat)abstract Objectives: To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin. Methods: Based on our findings during the 2017-2018 harvest (harvest 1), recommendations that enhanced the rest schedule and improved access to hydration and shade were given before the 2018-2019 harvest (harvest 2). Actual work conditions during harvest 2 were then observed. Serum creatinine (SCr) was measured before and at end-harvest, and cross-harvest changes in estimated glomerular filtration rate (eGFR) and incident kidney injury (IKI, ie, SCr increase by ≥0.30 mg/dL or ≥1.5 times the baseline value) were compared between harvest 1 and harvest 2 for three jobs with different physical workloads using regression modelling. Workers who left during harvest were contacted at home, to address the healthy worker selection effect. Results: In burned cane cutters, mean cross-harvest eGFR decreased 6 mL/min/1.73 m2 (95% CI 2 to 9 mL/min/1.73 m2) less and IKI was 70% (95% CI 90% to 50%) lower in harvest 2 as compared with harvest 1 data. No such improvements were seen among seed cutters groups with less successful intervention implementation. Conclusion: Kidney injury risk was again elevated in workers with strenuous jobs. The results support further efforts to prevent kidney injury among sugarcane workers, and other heat-stressed workers, by improving access to water, rest and shade. The distinction between design and implementation of such interventions should be recognised. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
22.	Grealish, Shane, et al. (författare) Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons. 2015 Ingår i: Stem Cell Reports. - : Elsevier BV. - 2213-6711. ; 4:6, s. 975-983 Tidskriftsartikel (refereegranskat)abstract Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson's disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circuitry after transplantation remain largely unknown. In this study, we use modified rabies virus to trace afferent and efferent connectivity of transplanted hESC-derived neurons in a rat model of PD and report that grafted human neurons integrate into the host neural circuitry in an unexpectedly rapid and extensive manner. The pattern of connectivity resembled that of local endogenous neurons, while ectopic connections were not detected. Revealing circuit integration of human dopamine neurons substantiates their potential use in clinical trials. Additionally, our data present rabies-based tracing as a valuable and widely applicable tool for analyzing graft connectivity that can easily be adapted to analyze connectivity of a variety of different neuronal sources and subtypes in different disease models.
23.	Hansson, Erik, et al. (författare) Workload and cross-harvest kidney injury in a Nicaraguan sugarcane worker cohort 2019 Ingår i: Occupational and environmental medicine. - : BMJ. - 1470-7926 .- 1351-0711. ; 76:11, s. 818-826 Tidskriftsartikel (refereegranskat)abstract OBJECTIVES: To examine the association between workload and kidney injury in a fieldworker cohort with different levels of physically demanding work over a sugarcane harvest, and to assess whether the existing heat prevention efforts at a leading occupational safety and health programme are sufficient to mitigate kidney injury. METHODS: Biological and questionnaire data were collected before (n=545) and at the end (n=427) of harvest among field support staff (low workload), drip irrigation workers (moderate), seed cutters (high) and burned sugarcane cutters (very high). Dropouts were contacted (87%) and reported the reason for leaving work. Cross-harvest incident kidney injury (IKI) was defined as serum creatinine increase ≥0.30 mg/dL or ≥1.5 times the baseline value, or among dropouts reporting kidney injury leading to leaving work. RESULTS: Mean cross-harvest estimated glomerular filtration rate change was significantly associated with workload, increasing from 0 mL/min/1.73 m2 in the low-moderate category to -5 mL/min/1.73 m2 in the high and -9 mL/min/1.73 m2 in the very high workload group. A similar pattern occurred with IKI, where low-moderate workload had 2% compared with 27% in the very high workload category. A healthy worker selection effect was detected, with 32% of dropouts reporting kidney injury. Fever and C reactive protein elevation were associated with kidney injury. CONCLUSIONS: Workers considered to have the highest workload had more cross-harvest kidney damage than workers with less workload. Work practices preventing heat stress should be strengthened and their role in preventing kidney damage examined further. Future occupational studies on chronic kidney disease of unknown aetiology should account for a healthy worker effect by pursuing those lost to follow-up.
24.	Herbertsson, Lina, et al. (författare) Bees increase seed set of wild plants while the proportion of arable land has a variable effect on pollination in European agricultural landscapes 2021 Ingår i: Plant Ecology and Evolution. - : Societe Royale de Botanique de Belgique. - 2032-3913 .- 2032-3921. ; 154:3, s. 341-350 Tidskriftsartikel (refereegranskat)abstract Background and aims: Agricultural intensification and loss of farmland heterogeneity have contributed to population declines of wild bees and other pollinators, which may have caused subsequent declines in insect-pollinated wild plants.Material and methods: Using data from 37 studies on 22 pollinator-dependent wild plant species across Europe, we investigated whether flower visitation and seed set of insect-pollinated plants decline with an increasing proportion of arable land within 1 km.Key results: Seed set increased with increasing flower visitation by bees, most of which were wild bees, but not with increasing flower visitation by other insects. Increasing proportion of arable land had a strongly variable effect on seed set and flower visitation by bees across studies.Conclusion:Factors such as landscape configuration, local habitat quality, and temporally changing resource availability (e.g. due to mass-flowering crops or honey bee hives) could have modified the effect of arable land on pollination. While our results highlight that the persistence of wild bees is crucial to maintain plant diversity, we also show that pollen limitation due to declining bee populations in homogenized agricultural landscapes is not a universal driver causing parallel losses of bees and insect-pollinated plants.
25.	Idborg, Helena, et al. (författare) STRATIFICATION OF SLE PATIENTS FOR IMPROVED DIAGNOSIS AND TREATMENT 2013 Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 72, s. A80-A80 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract Background. Systemic autoimmune diseases (SAIDs) affect about 2% of the population in Western countries. Sufficient diagnostic criteria are lacking due to the heterogeneity within diagnostic categories and apparent overlap regarding symptoms and patterns of autoantibodies between different diagnoses. Systemic lupus erythematosus (SLE) is regarded as a prototype for SAIDs and we hypothesise that subgroups of patients with SLE may have different pathogenesis and should consequently be subject to different treatment strategies.Objectives. Our goal is to find new biomarkers to be used for the identification of more homogenous patient populations for clinical trials and to identify sub-groups of patients with high risk of for example cardiovascular events.Methods. In this study we have utilised 320 SLE patients from the Karolinska lupus cohort and 320 age and gender matched controls. The SLE cohort was characterised based on clinical, genetic and serological data and combined by multivariate data analysis in a systems biology approach to study possible subgroups. A pilot study was designed to verify and investigate suggested subgroups of SLE. Two main subgroups were defined: One group was defined as having SSA and SSB antibodies and a negative lupus anticoagulant test (LAC), i.e., a “Sjögren-like” group. The other group was defined as being negative for SSA and SSB antibodies but positive in the LAC test.i.e. an “APS-like” group. EDTA-plasma from selected patients in these two groups and controls were analysed using a mass spectrometry (MS) based proteomic and metabolomic approach. Pathway analysis was then performed on the obtained data.Results. Our pilot study showed that differences in levels of proteins and metabolites could separate disease groups from population controls. The profile/pattern of involved factors in the complement system supported a division of SLE in two major subgroups, although each individual factor was not significantly different between subgroups. Complement factor 2 (C2) and membrane attack complex (MAC) were analysed in the entire cohort with complementary methods and C2 verifies our results while the levels of MAC did not differ between SLE subgroups. The generated metabolomics data clearly separated SLE patients from controls in both gas chromatography (GC)-MS and liquid chromatography (LC)-MS data. We found for example that tryptophan was lower in the SLE patients compared to controls.Conclusions. Our systems biology approach may lead to a better understanding of the disease and its pathogenesis, and assigning patients into subgroups will result in improved diagnosis and better outcome measures of SLE.
26.	Idborg, Helena, et al. (författare) Systems biology of SLE : biochemical characterisation of subgroups within SLE for improved diagnosis and treatment 2012 Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 71, s. A12- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
27.	Jakobsson, Anna, et al. (författare) Retrieval-based learning versus discussion : which review practice will better enhance primary school students’ knowledge of scientific content? 2023 Ingår i: International Journal of Science Education. - : Taylor & Francis Group. - 0950-0693 .- 1464-5289. Tidskriftsartikel (refereegranskat)abstract Retrieval-based learning, using tests for content review, frequently proves more effective for knowledge retention compared to alternative methods. Extensive research has explored this with older students, often in contrast to more passive techniques like rereading or note rewriting, typically focusing on vocabulary content, in non-classroom settings and assessing knowledge retention within a week. In this study we conducted a classroom experiment to compare the efficacy of retrieval-based learning to another active method of reviewing content, namely discussion, in promoting long-term knowledge retention among primary school science students. Additionally, we assessed the students’ perceptions of these reviewing methods. A total of eighty-one primary school students participated in the study, which encompassed a lesson conducted at a zoo, followed by a review of the lesson content using either retrieval-based learning or discussion. Our findings indicated no impact of the method of reviewing on knowledge retention after either one week or four weeks. Nevertheless, notable effects were observed in terms of motivation, as students who employed retrieval-based learning for reviewing reported heightened levels of interest and enjoyment, along with perceiving greater benefits from the process. Additionally, boys in the discussion group reported increased curiosity, in contrast to girls who reported an inverse pattern.
28.	Jakobsson, Björn, et al. (författare) Samverkan i rehabilitering av Betaprojektet i Kungsbacka kommun. kort om utvärdering av Stockholmsprojektet samt en jämförelse med utvärdering av FRISAM Projektrapport 2001 Rapport (övrigt vetenskapligt/konstnärligt)
29.	Jakobsson, Björn, et al. (författare) Utvärdering av Stockholmsprojektet : Rehabilitering i samverkan - Slutrapport 2000 Rapport (övrigt vetenskapligt/konstnärligt)
30.	Jakobsson, Hilda, 1984- (författare) Jag var kvinna : Flickor, kärlek och sexualitet i Agnes von Krusenstjernas tidiga romaner 2018 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The Swedish author Agnes von Krusenstjerna is known for her depictions of girls becoming women, a motif that she returns to again and again throughout her works. Previous academic literature on Krusenstjerna highlights that she writes about girls, maturation, and eroticism, but does not explore what ‘becoming a woman’ means. While the terms ‘girl’ and ‘woman’ are commonly regarded as signifiers of age and sex only, they are in fact laden with a number of assumptions, which I explore in Krusenstjerna’s novels. This thesis analyses the depictions of girls coming of age through their encounter with love and sexuality in Krusenstjerna’s early novels Ninas dagbok (The Diary of Nina, 1917), Helenas första kärlek (Helena’s First Love, 1918), and the Tony trilogy Tony växer upp (Tony Grows Up, 1922), Tonys läroår (Tony’s Apprenticeship, 1924), and Tonys sista läroår (Tony’s Last Apprenticeship, 1926). I explore how the idea of girls becoming women relates to love and sexuality, and I pose the following questions: How is the term ‘girl’ constructed in Krusenstjerna’s early novels? How does a girl become a woman and what implications does womanhood have? Which characters and phenomena in the girl’s surroundings constitute the conditions for her becoming a woman, and which ones risk delaying or even preventing this transition? Furthermore, I seek to connect the depiction of girls, love, and sexuality with Krusenstjerna’s contemporary literary critics’ view of her early novels as girls’ books, i.e. novels for young women, or associated with that literary tradition, even though they were not published as such. I use a combination of feminist and queer theory focussing on temporality. Throughout the thesis, I connect Krusenstjerna’s writings to those of other authors. The following novels are connected to the tradition of books for girls and are used as the starting point for my hermeneutical readings of Krusenstjerna’s works: The Girls at His Billet (1916) by Berta Ruck, Little Lord Fauntleroy (1886) by Frances Hodgson Burnett, Daddy-Long-Legs (1912) and Dear Enemy (1915) by Jean Webster, as well as Anne of Green Gables (1908), The Blue Castle (1926), and Emily’s Quest (1927) by L. M. Montgomery. Examining these novels, I focus on the motif of girls becoming women as well as a selection of other related topics. The thesis addresses two different ways of coming of age depicted in Krusenstjerna’s early novels. The protagonists of the first two novels, Nina and Helena, are portrayed as ‘girls’ who become ‘women’ through their encounter with men and their choice in love, whereas the protagonist of the Tony trilogy is described as a ‘girl’ who only temporarily becomes a ‘woman’ but then turns into a ‘girl’ again. Accordingly, the act of becoming a woman in Krusenstjerna’s first two novels, which is typical for the girls’ book tradition, follows normative expectations of the life trajectory, whereas the queer act of becoming – or rather un-becoming – a woman in the later Tony trilogy does not adhere to the same assumptions. I argue that the fact that the second part of the Tony trilogy has the same plot as Ninas dagbok, and the third instalment the same story as Helenas första kärlek, amplifies the impression that the Tony trilogy queers the normative life trajectory that is found in those two novels and is typical for the girls’ book tradition. Thus, as this thesis proposes, the girls’ book as seen in Krusenstjerna’s work, is queered.
31.	Jakobsson, Jenny, 1975-, et al. (författare) Everyday challenges following hospital discharge. A multi-method study identifying and describing areas of concern for patients during the first month after colorectal cancer surgery 2023 Ingår i: Nursing Open. - : John Wiley & Sons. - 2054-1058. ; 10:4, s. 2172-2181 Tidskriftsartikel (refereegranskat)abstract AIM: Identify and describe areas of concern focusing on day-to-day variations during the first month after surgery for patients recovering from colorectal cancer surgery.DESIGN: A multi-method design was applied using diaries and interviews.METHOD: Data was collected using semi-structured diaries kept 1 month after surgery by seven patients recovering from colorectal cancer surgery. Also, face-to-face interviews were conducted 1 month after surgery. Data from the diaries constituted a framework for the following directed content analysis of interviews.FINDINGS: Low levels of pain were experienced but caused reduced mobility and tiredness. Practical matters in daily living were restricted, while social life could be hampered by a frequent need to defecate. Appetite and consequently the ability to eat and drink was the most prominent concern, due to changes in taste and ability to tolerate food. Worries were mainly related to changes in bowel movements. No Patient or Public Contribution.
32.	Jakobsson, Jenny, 1975-, et al. (författare) Exploring workplace violence on surgical wards in Sweden : a cross-sectional study 2023 Ingår i: BMC Nursing. - : BioMed Central (BMC). - 1472-6955. ; 22:1 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Workplace violence is a global threat to healthcare professionals' occupational health and safety and the situation has worsened during the COVID-19 pandemic. This study aimed to explore workplace violence directed against assistant and registered nurses working on surgical wards in Sweden.METHODS: This cross-sectional study was conducted in April 2022. Using a convenience sampling procedure, 198 assistant and registered nurses responded to an online questionnaire developed for this specific study. The questionnaire comprised 52 items and included, among other items, subscales from validated and previously used instruments. Data analysis included descriptive statistics, the chi-square test, and independent-samples t-test.RESULTS: The most frequently reported type of workplace violence was humiliation (28.8%), followed by physical violence (24.2%), threats (17.7%), and unwanted sexual attention (12.1%). Patients and patients' visitors were reported as the main perpetrators of all kinds of exposure. Additionally, one third of the respondents had experienced humiliation from colleagues. Both threats and humiliation showed negative associations with work motivation and health (p < 0.05). Respondents classified as working in a high- or moderate-risk environment were more frequently exposed to threats (p = 0.025) and humiliation (p = 0.003). Meanwhile, half of the respondents were unaware of any action plans or training regarding workplace violence. However, of those who indicated that they had been exposed to workplace violence, the majority had received quite a lot or a lot of support, mainly from colleagues (range 70.8-80.8%).CONCLUSION: Despite a high prevalence of workplace violence, and especially of humiliating acts, there appeared to be low preparedness within the hospital organizations to prevent and/or handle such incidents. To improve these conditions, hospital organizations should place more emphasis on preventive measures as part of their systematic work environment management. To help inform such initiatives, it is suggested that future research should focus on the identification of suitable measures regarding different types of incidents, perpetrators, and settings.
33.	Jakobsson, Jenny (författare) Fast-track kirurgi för den äldre populationen 2013 Ingår i: Omvårdnad på avancerad nivå. - : Studentlitteratur AB. - 9789144071459 Bokkapitel (övrigt vetenskapligt/konstnärligt)
34.	Jakobsson, Jenny, et al. (författare) General health and state anxiety in patients recovering from colorectal cancer surgery 2016 Ingår i: Journal of Advanced Nursing. - : John Wiley & Sons. - 0309-2402 .- 1365-2648. ; 72:2, s. 328-338 Tidskriftsartikel (refereegranskat)abstract AIM: To describe and compare general health and state anxiety before surgery and up to 6 months after surgery in patients with colorectal cancer undergoing elective rectal resection, abdominoperineal resection or colonic resection in an enhanced recovery context. BACKGROUND: Little is known about patient-reported health and anxiety after colorectal cancer surgery in an enhanced recovery context. DESIGN: A prospective cohort study. METHODS: Data were collected from October 2011-February 2013. The questionnaires - EuroQol 5-Dimensions 3-Levels and State-Trait Anxiety Inventory - were answered before surgery, at discharge and 1 and 6 months after surgery. Data were analysed using inferential statistics to describe differences between groups of patients (Kruskal-Wallis test) and between assessments within groups (Friedman's anova). RESULTS: Patients (N = 105), divided into three groups based on surgical procedure, showed a high health index and a low state anxiety in all assessments without differences between the groups. Patients considered for abdominoperineal resection rated their pre-operative health as significantly higher than patients after rectal and colonic resections did. Within groups, patients recovering from abdominoperineal resection and rectal resection deteriorated significantly in health index 1 month after surgery. However, after 6 months they had improved again. After colonic resection, patients improved significantly in self-rated health and anxiety 1 month after surgery with no further discernible improvement after 6 months. CONCLUSION: The study showed that patients generally had a high level of health and a low level of anxiety throughout the study period. Only a few differences occurred between assessments within groups.
35.	Jakobsson, Jonas K F, et al. (författare) Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease 2018 Ingår i: BMC Pulmonary Medicine. - : BioMed Central Ltd.. - 1471-2466. ; 18:1 Tidskriftsartikel (refereegranskat)abstract Background: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease. Methods: Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests. Results: We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001-0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson's r = 0.80-0.85, p < 0.002) while this correlation was not found within the other groups. Conclusions: Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.
36.	Jakobsson, Jenny, et al. (författare) Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. 2006 Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 91:2, s. 687-93 Tidskriftsartikel (refereegranskat)abstract CONTEXT: The reproductive endocrinology in Asians and Caucasians is of great interest in view of large differences in prostate cancer rate and sensitivity to pharmacological male contraception. In addition, interpretation of certain antidoping tests is confounded by interethnic variation in androgen disposition. Uridine diphosphoglucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene. OBJECTIVE: The objective of the study was to evaluate the contribution of the UGT2B17 deletion polymorphism to the interindividual and interethnic variation of androgen metabolism and excretion. METHODS AND RESULTS: Urine from 122 Swedish and 74 Korean healthy men was analyzed for several androgen glucuronides including testosterone. The distribution of the natural logarithms of urinary testosterone concentrations showed a distinct bimodal pattern in both groups, suggesting a monogenic inheritance. When the UGT2B17 genotypes were compared with urinary testosterone levels, all of the individuals of the UGT2B17 homozygous deletion/deletion genotype had no or negligible amounts of urinary testosterone. The deletion/deletion genotype was seven times more common in the Korean (66.7%) than the Swedish population (9.3%). In addition, the Swedes had significantly higher levels of serum testosterone, compared with the Koreans. CONCLUSIONS: Our results show that the UGT2B17 polymorphism is strongly associated with the bimodal distribution of the testosterone excretion and also with the large differences in testosterone excretion between Koreans and Swedes.
37.	Jakobsson, Jenny, et al. (författare) Nurses' perceptions of working according to standardized care plans : a questionnaire study 2013 Ingår i: Scandinavian Journal of Caring Sciences. - : John Wiley & Sons. - 0283-9318 .- 1471-6712. ; 27:4, s. 945-952 Tidskriftsartikel (refereegranskat)abstract Aims The aim of this study was to investigate nurses′ perceptions of working according to standardized care plans (SCPs), regarding usability, documentation, quality of care and the implementation process. Background Administrative work is an extensive part of nursing practice which leads to decreased time for the near patient-related care. In addition, the number of very sick patients with short hospital stays has increased. This places new demands on healthcare teams to guarantee a high quality of care. For this reason development and use of standardized care plans has increased in Sweden during recent years. Method This was a cross-sectional survey and 116 registered nurses who had experience of working according SCPs answered a questionnaire with the option of providing written comments. Result The nurses reported that the use of SCPs facilitated their daily work, especially for new employees and worked well as a checklist ensuring the quality of care. The documentation was experienced as easy, less time consuming with less redundant information. The implementation process of SCPs was reported as satisfactory but a majority reported that they were not involved in the development of the SCP. However, even though 85.5% reported a positive attitude towards working according to an SCP, it was also sometimes experienced as inflexible. Conclusion The nurses had overall positive perceptions of working according to an SCP mainly in terms of usability, documentation and quality of care. The implementation process was not optimal and it was doubtful whether the SCP rendered any positive side effects.
38.	Jakobsson, Jenny, et al. (författare) Optimal kirurgisk återhämtning (ERAS) 2016 Ingår i: Omvårdnad och kirurgi. - : Studentlitteratur AB. - 9789144088860 ; , s. 157-163 Bokkapitel (övrigt vetenskapligt/konstnärligt)
39.	Jakobsson, Jenny, et al. (författare) Patient characteristics and surgery-related factors associated with patient-reported recovery at 1 and 6 months after colorectal cancer surgery 2017 Ingår i: European Journal of Cancer Care. - : John Wiley & Sons. - 0961-5423 .- 1365-2354. ; 26:6 Tidskriftsartikel (refereegranskat)abstract Predictors for postoperative recovery after colorectal cancer surgery are usually investigated in relation to length of stay (LoS), readmission, or 30-day morbidity. This study describes patient characteristics and surgery-related factors associated with patient-reported recovery 1 and 6 months after surgery. In total, 153 consecutively included patients who were recovering from colorectal cancer surgery reported their level of recovery using the Postoperative Recovery Profile. Multiple logistic regression analysis was used to calculate associations with recovery, defined as good or poor, divided into five recovery dimensions: physical symptoms, physical functions, psychological, social and activity. Better preoperative health predicted good recovery regarding three dimensions 1 month after surgery. Regarding all dimensions 1 month after surgery, poor recovery was predicted by a poor recovery on the day of discharge within corresponding dimensions. Higher age was associated with good recovery 6 months after surgery, while chemotherapy showed negative associations. Overall, a majority of factors had a negative impact on recovery, but without any obvious relation to one specific dimension or point in time. Those factors were: high Body Mass Index, comorbidity, abdominoperineal resection, loop ileostomy, colostomy and LoS. This study illustrates the complexity of postoperative recovery and a need for individualised follow-up strategies.
40.	Jakobsson, Jenny, et al. (författare) Patient-reported recovery after enhanced colorectal cancer surgery : a longitudinal six-month follow-up study 2014 Ingår i: International Journal of Colorectal Disease. - : Springer. - 0179-1958 .- 1432-1262. ; 29:8, s. 989-998 Tidskriftsartikel (refereegranskat)abstract Syfte: Konceptet enhanced recovery after surgery (ERAS) är en modern vårdregim och många studier har bekräftat dess positiva inverkan på återhämtningen efter kolorektal kirurgi. Det finns dock sparsamt med kunskap om patienternas fortsatta återhämtning efter utskrivning. Därav var syftet med denna studie att beskriva patientrapporterad återhämtning efter kolorektal cancerkirurgi enligt ERAS från utskrivningsdagen till 1 och 6 månader efter kirurgi. Metod: Mätningar gjordes vid utskrivning, efter 1 månad och sex månader efter operation med hjälp av frågeformuläret Postoperative Recovery Profile (PRP). Totalt 119 patienter vilka opererats med rektumamputation, rektumresektion och kolonresektion svarade vid alla tre mättillfälle. Resultat: Global Score of Recovery visade att inga patienter upplevde sig som helt återhämtade vid utskrivning. Efter rektumresektion upplevde många sig som inte alls återhämtad. En månad efter kirurgi rapporterade patienter som återhämtade sig efter kolonresektion signifikanta förbättringar i 11 av 17 item samtidigt som patienter efter rektumamputation inte visade någon signifikant förbättring. Istället visades högre nivåer av problem gällande item som fatigue, muskelsvaghet och nedstämdhet. Rektumresektioner rapporterade signifikanta förbättringar mellan 1 och 6 månader efter kirurgi gällande 7 av 19 item. Dock urskiljde sig det item som handlade om gastrointestinal funktion då patienterna upplevde en signifikant försämring vid 6 månader efter operation. Sammanfattning: Denna studie belyser skillnaderna mellan olika grupper av patienter och skillnaderna i deras återhämtning. Detta visar på olika behov av stöd efter utskrivning.
41.	Jakobsson, Jenny, 1975- (författare) Psychometric Evaluation of the Postoperative Recovery Profile 2023 Ingår i: Nursing Research and Practice. - : Hindawi Publishing Corporation. - 2090-1429 .- 2090-1437. ; 2023 Tidskriftsartikel (refereegranskat)abstract AIM: To further evaluate the postoperative recovery profile regarding its psychometric properties.BACKGROUND: The postoperative recovery profile is an instrument for the self-assessment of general postoperative recovery that has received increased attention within nursing research. However, psychometric evaluation during development was sparse.DESIGN: Psychometric evaluation was done using classical test theory.METHOD: Data quality, targeting, reliability, and scaling assumptions were measured. In addition, confirmatory factor analysis was used to evaluate construct validity. Data collection was made during 2011-2013.RESULT: Data derived from this study showed acceptable quality; however, item distribution was skewed, with ceiling effects in the majority of items. Cronbach's alpha showed high internal consistency. Item-total correlations indicated unidimensionality, whereas six items demonstrated high correlations pointing at redundancy. The confirmatory factor analysis confirmed problems related to dimensionality as the five proposed dimensions were highly correlated with each other. Furthermore, items were largely uncorrelated with the designated dimensions.CONCLUSION: This study shows that the postoperative recovery profile needs to be further developed to serve as a robust instrument within nursing as well as medical research. Arguably, values from the instrument should not be calculated at a dimensional level for the time being because of discriminant validity issues.
42.	Jakobsson, Jenny, et al. (författare) Searching for Evidence Regarding Using Preoperative Disinfection Showers to Prevent Surgical Site Infections : A Systematic Review 2011 Ingår i: Worldviews on Evidence-Based Nursing. - : Wiley. - 1545-102X .- 1741-6787. ; 8:3, s. 143-152 Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract Background: Postoperative surgical site infections (SSI) are the third most common health care associated infection. Even though several studies have pointed out the benefits of disinfection showers prior to surgery in order to reduce SSI, it remains unclear how to optimize this disinfection procedure. Aim: To find evidence for how many times preoperative disinfection showers should be performed in order to reduce bacterial colonies and minimize the risk of SSI. Method: A comprehensive literature search of multiple databases published during 1986-2008, supplemented by a manual search of the references in all relevant articles. Protocols were used in quality assessment and the data synthesis is descriptive in a narrative form. Results: The 10 studies included had different designs, interventions, and samples, which makes it difficult to compare them. Moreover, the quality of the reviewed studies varied and only four had a high level of evidence. Therefore, the results failed to give an unambiguous answer about the optimal number of preoperative showers, so only assumptions can be made. It is quite obvious, however, that preoperative disinfection showers with chlorhexidine gluconate (CHG) are effective from a microbiological point of view since eight of the reviewed studies showed a sharply reduced skin flora after using CHG. Conclusions: Currently, clear evidence for how many times preoperative disinfection showers should be performed to minimize the risk of SSI is missing. This highlights the need for further research that focuses on the number of preoperative disinfection showers in relation to SSI, in order to obtain optimal effect. Until then, it would be wise to follow previously made recommendation of three to five preoperative showers. Moreover, in order to have the intended effect of preoperative disinfection, it is important that health care professionals have the knowledge to guide patients with information and clear instructions about disinfection shower procedures.
43.	Jakobsson, Jenny, 1975- (författare) State of Recovery 6 Months After Rectal Cancer Surgery : Postoperative Symptoms and Differences With Regard to Surgical Procedure 2021 Ingår i: Gastroenterology Nursing. - : Lippincott Williams & Wilkins. - 1042-895X .- 1538-9766. ; 44:2, s. 98-105 Tidskriftsartikel (refereegranskat)abstract Rectal cancer surgery has developed to be highly technological and precise. Nevertheless, postoperative symptoms can affect patients for a long time after surgery and might also be persistent. The purpose of this study was to describe the level of postoperative symptoms 6 months after rectal cancer surgery as well as differences in symptoms with regard to surgical procedure. Data from 117 patients recovering from rectal cancer surgery were collected 6 months after surgery using the Postoperative Recovery Profile (PRP) questionnaire measuring self-reported postoperative symptoms. Results showed that the majority of patients had no or mild problems with the 19 symptoms recorded in the questionnaire. There was a significant difference between surgical procedures: patients after anterior resection experienced mild problems in gastrointestinal function (physical domain) and interest in their surroundings (social domain), whereas most patients after abdominoperineal resection and abdominoperineal resection with myocutaneous flap showed no problems. In all groups, a considerably high proportion of patients reported severe problems in sexual activity (physical domain). Findings in this study emphasize that healthcare professionals should pay attention to patients recovering from anterior resection especially regarding problems in the gastrointestinal function. Moreover, there is a need to acknowledge eventual sexual dysfunctions in all rectal cancer patients.
44.	Jakobsson, Jenny, et al. (författare) The Face of Workplace Violence : Experiences of Healthcare Professionals in Surgical Hospital Wards 2020 Ingår i: Nursing Research and Practice. - : Hindawi Publishing Corporation. - 2090-1429 .- 2090-1437. ; 2020 Tidskriftsartikel (refereegranskat)abstract Background: Though workplace violence (WPV) is a global problem for healthcare professionals, research within in-hospital care has mainly focused on WPV in emergency healthcare settings. Thus, the number of qualitative studies that explores experiences of WPV in general hospital wards with a longer length of stay is limited.Aim: The aim of this study was to explore how healthcare professionals in surgical hospital wards experience and manage WPV perpetrated by patients or visitors.Method: . Exposure to WPV is a problem for healthcare professionals in surgical wards and has consequences for the patients. Preventive strategies, guidelines, and action plans are urgently needed to minimise the risk of WPV and to ensure a safe work and care environment.
45.	Jakobsson, Jenny, et al. (författare) The lived experience of recovery during the first 6 months after colorectal cancer surgery 2017 Ingår i: Journal of Clinical Nursing. - : John Wiley & Sons. - 0962-1067 .- 1365-2702. ; 26:23-24, s. 4498-4505 Tidskriftsartikel (refereegranskat)abstract AIMS AND OBJECTIVES: To describe the lived experience of recovery during the first 6 months after colorectal cancer surgery. BACKGROUND: Colorectal cancer is the third most common cancer diagnosis worldwide. Early discharge places demands on healthcare professionals to prepare patients for their return home and to provide them with appropriate support throughout the recovery process. This requires knowledge of what it is like to recover from colorectal cancer surgery. DESIGN: A qualitative phenomenological design was used to describe the structure of recovery after colorectal cancer surgery. METHODS: Ten patients recovering from colorectal cancer surgery were interviewed at one month and six months after surgery. The descriptive phenomenological method by Giorgi was used throughout the study. RESULTS: Postoperative recovery was described as a progressive process. This process was accompanied by experiences of physical powerlessness, difficulties with food intake, altered bowel function and dependency on others. The experiences were most intense at the beginning of the recovery but disappeared as time went by and normality in life returned. CONCLUSION: While recovering from colorectal cancer surgery, patients experience obstacles that impede their ability to live life as normal. Six months after surgery, those experiences disappear or become adjusted to being part of normal life. RELEVANCE TO CLINICAL PRACTICE: Patients should be provided with information about the expected postoperative recovery before discharge from hospital. The need for professional support appears to be most frequently needed in early recovery, but it should be considered on an individual basis.
46.	Jakobsson, Jenny (författare) The process of recovery after colorectal cancer surgery : patients' experiences and factors of influence 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The aim of this thesis was to describe and compare how patients recovering from different forms of colorectal cancer surgery experience their postopera-tive recovery, general health, and anxiety, up to six months after surgery. In addition, the aim was to describe the influence of patient- and surgery-related factors on patient-reported recovery. Data was collected through questionnaires containing instruments measuring general health, trait and state anxiety, and recovery. Recruitment was made consecutively. In total, 176 patients chose to participate and received the questionnaires before surgery, on the day of discharge, and one and six months after surgery. In addition, information concerning patient character-istics and factors related to surgery were retrieved from the patients’ medical journals. Data was also collected through in-depth interviews one and six months after surgery with ten purposefully included patients. Postoperative recovery after colorectal cancer surgery was described as a pro-gressive process. Experiences of physical powerlessness, difficulties with food intake, altered bowel function, and dependence on others, were prominent and changed from being intense in the beginning of the process to gradually disappearing as time went by. On the day of discharge, no patient was considered fully recovered or almost fully recovered. Thereafter, it could be seen that patients after colonic resec-tion improved regarding the majority of symptoms connected to recovery al-ready during the first month after surgery, while patients after abdominoper-ineal resection deteriorated somewhat. Patients after rectal resection recovered better during the first month than those after an abdominoperineal resection but not as well as patients after colonic resection. Health was shown to be generally good preoperatively. One month after surgery, patients recovering from abdominoperineal resection and rectal resection had a temporary reduc-tion in health, while patients after a colonic resection had improved. Six months after surgery, health had improved to better than preoperative values without any differences between groups of patients. Regarding anxiety, both as a trait and as a state, this was shown to be low, without any differences between groups. Once at home from hospital, the patients experienced a continued difficulty with food intake, and the physical powerlessness made them initially de-pendent on relatives or friends in order to manage everyday life. The bowel function as well as the practical management of a possible stoma caused feel-ings of insecurity and concern. During the period from one month to six months after surgery, improvements were seen in symptoms connected to re-covery for all patients and especially after abdominoperineal resection. How-ever, it was also clear that patients after a rectal resection had not recovered to the same extent as those after an abdominoperineal or colonic resection. Some factors related to patient characteristics and surgery were shown to be associated with the odds for a good recovery one and six months after sur-gery. Those factors were age, grade of ASA, EQ VAS, EQ index, BMI, dura-tion of surgery, APR procedure, presence of stoma, LoS, and postoperative treatment. In addition, the dimensional levels of recovery could to a great ex-tent predict recovery in corresponding dimensions. The result of this thesis showed a diverse pattern of recovery. Nevertheless, there were also some similarities. This illustrates the complexity of postoper-ative recovery. In order to avoid unnecessary concerns, it is important for health care professionals to provide the patients with appropriate infor-mation and support throughout the whole recovery period and to design in-dividual follow-up strategies.
47.	Jakobsson, Jenny, 1975-, et al. (författare) Workplace violence from the perspective of hospital ward managers in Sweden : A qualitative study 2022 Ingår i: Journal of Nursing Management. - : John Wiley & Sons. - 0966-0429 .- 1365-2834. ; 30:6, s. 1523-1529 Tidskriftsartikel (refereegranskat)abstract AIM: The aims of the study are to explore workplace violence perpetrated by patients or visitors from the perspective of hospital ward managers and to describe how ward managers perceive their leadership role and manage related incidents.BACKGROUND: Few studies focus on workplace violence from the perspective of ward managers even though they are the closest managers to the operational staff.METHOD: Fifteen semistructured interviews were analysed using qualitative content analysis.RESULTS: Four categories emerged: the face of workplace violence, a two-fold assignment, strive towards readiness to act, and managing incidents.CONCLUSION: While the most common acts of workplace violence are considered less serious and related to patients' medical conditions or dissatisfied visitors, hospital organizations focus on serious but rarely occurring incidents. Consequently, ward managers have limited opportunities to ensure a safe work environment on an everyday basis.IMPLICATIONS FOR NURSING MANAGEMENT: To support ward managers' occupational safety and health management, workplace violence prevention and management should be acknowledged as an important responsibility for senior management in hospitals. It is important to identify incidents that most likely will occur at the wards and to create strategies related to those incidents. Strategies could include risk assessments, prevention, evaluation, education and reflection combined with, for example, scenario training.
48.	Jakobsson, Mattias, et al. (författare) A unique recent origin of the allotetraploid species Arabidopsis suecica: Evidence from nuclear DNA markers 2006 Ingår i: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 23:6, s. 1217-1231 Tidskriftsartikel (refereegranskat)abstract A coalescent-based method was used to investigate the origins of the allotetraploid Arabidopsis suecica, using 52 nuclear microsatellite loci typed in eight individuals of A. suecica and 14 individuals of its maternal parent Arabidopsis thaliana, and four short fragments of genomic DNA sequenced in a sample of four individuals of A. suecica and in both its parental species A. thaliana and Arabidopsis arenosa. All loci were variable in A. thaliana but only 24 of the 52 microsatellite loci and none of the four sequence fragments were variable in A. suecica. We explore a number of possible evolutionary scenarios for A. suecica and conclude that it is likely that A. suecica has a recent, unique origin between 12,000 and 300,000 years ago. The time estimates depend strongly on what is assumed about population growth and rates of mutation. When combined with what is known about the history of glaciations, our results suggest that A. suecica originated south of its present distribution in Sweden and Finland and then migrated north, perhaps in the wake of the retreating ice.
49.	Jakobsson Schulze, Jenny (författare) Genetics of androgen disposition : implications for doping tests 2007 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Anabolic androgenic steroids (AAS) are derivatives of testosterone. Doping with AAS is a severe challenge to the vision, moral and ethics in sports and has also become an increasing problem in society. Testosterone abuse is conventionally assessed by the urinary testosterone glucuronide/ epitestosterone glucuronide (T/E) ratio, levels above 4.0 being considered suspicious. However, there is a large inter-individual variation in testosterone glucuronide and epitestosterone glucuronide excretion, which challenges the accuracy of the test. There are reasons to believe that genetic variation is the single most important cause of variation in disposition of many androgenic compounds. Twin studies in men have demonstrated heritability estimates of 85% and 96% for production rates of testosterone and dihydrotestosterone, respectively. The primary aim of this thesis was to investigate the contribution of genetic components to inter-individual variation in androgen disposition. We found that a deletion polymorphism in the UGT2B17 gene was strongly associated with the urinary testosterone glucuronide levels. All individuals homozygous for the deletion had negligible amounts of urinary testosterone glucuronide. It is a common polymorphism with an allele frequency of 29 % in Swedes and 78 % in Koreans. After a single dose of 360 mg testosterone, 40 % of the subjects homozygous for the UGT2B17 deletion never reached the T/E cut off ratio of 4.0. We showed that the sensitivity and specificity of the T/E test could be markedly improved by using genotype-based cut off ratios. A CYP17 T>C promoter polymorphism was associated with urinary epitestosterone glucuronide levels and consequently the T/E ratio. High natural T/E ratios due to low urinary levels of epitestosterone glucuronide may be partly explained by this polymorphism. Considering only individuals with a functional UGT2B17 enzyme, carriers of the CYP17 TT genotype exhibited 64 % higher T/E ratios than men with one or two C-alleles. The frequency of the TT genotype was 35 % in Caucasians. Another polymorphism (E77G) in 17b-hydroxysteroid dehydrogenase type 5 (HSD17B5), an enzyme that catalyses the step between androstenedione and testosterone, was associated with serum testosterone levels in Caucasian men. Considering only individuals with a functional UGT2B17 enzyme, this polymorphism was also associated with urinary testosterone glucuronide levels. The polymorphism had an allele frequency of 4.8 % in Swedes but was completely absent in Koreans. We also found a novel functional promoter polymorphism in the CYP7B1 gene, which was associated with significantly higher promoter activity and had an allele frequency of 4 % in Swedes and 0.65 % in Koreans. In summary, genetic variation has a large impact on androgen disposition. This variation is of the utmost importance for the interpretation of doping test results. The role of this variation for diseases in steroid target organs or for endocrine adverse reactions to drugs remains to be elucidated.
50.	Johansson, Gerd, et al. (författare) OpDesign – A study of the working environment in an operating unit 2014 Konferensbidrag (refereegranskat)

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