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| 2. |
- Rofors, E., et al.
(författare)
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Response of a Li-glass/multi-anode photomultiplier detector to collimated thermal-neutron beams
- 2021
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 999
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Tidskriftsartikel (refereegranskat)abstract
- The response of a position-sensitive Li-glass scintillator detector being developed for thermal-neutron detection with 6 mm position resolution has been investigated using collimated beams of thermal neutrons. The detector was moved perpendicularly through the neutron beams in 0.5 to 1.0 mm horizontal and vertical steps. Scintillation was detected in an 8 × 8 pixel multi-anode photomultiplier tube on an event-by-event basis. In general, several pixels registered large signals at each neutron-beam location. The number of pixels registering signal above a set threshold was investigated, with the maximization of the single-hit efficiency over the largest possible area of the detector as the primary goal. At a threshold of ∼50% of the mean of the full-deposition peak, ∼80% of the events were registered in a single pixel, resulting in an effective position resolution of ∼5 mm in X and Y. Lower thresholds generally resulted in events demonstrating higher pixel multiplicities, but these events could also be localized with ∼5 mm position resolution.
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| 3. |
- Rofors, E., et al.
(författare)
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Response of a Li-glass/multi-anode photomultiplier detector to focused proton and deuteron beams
- 2020
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 984
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Tidskriftsartikel (refereegranskat)abstract
- The response of a position-sensitive Li-glass based scintillation detector being developed for thermal-neutron detection with 6 mm position resolution has been investigated using focused beams of 2.5MeV protons and deuterons. The beams were scanned across the detector in 0.5 mm horizontal and vertical steps perpendicular to the beams. Scintillation light was registered using an 8 × 8 pixel multi-anode photomultiplier tube. The signal amplitudes were recorded for each pixel on an event-by-event basis. Several pixels generally registered considerable signals at each beam location. To optimize planned detector operation at the European Spallation Source, the number of pixels above set thresholds was investigated, with the maximization of the single-hit efficiency over the largest possible area as the primary goal. For both beams, at a threshold of ∼50% of the mean of the full-deposition peak, ∼80% of the events were registered in a single pixel, resulting in an effective position resolution of ∼5 mm in X and Y. Lower thresholds resulted in higher pixel multiplicities. These events could also be localized with the same effective position resolution.
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| 4. |
- Sumitran-Holgersson, S, et al.
(författare)
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Generation of hepatocyte-like cells from in vitro transdifferentiated human fetal pancreas
- 2009
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Ingår i: Cell transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 18:2, s. 183-193
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Tidskriftsartikel (refereegranskat)abstract
- Although the appearance of hepatic foci in the pancreas has been described in animal experiments and in human pathology, evidence for the conversion of human pancreatic cells to liver cells is still lacking. We therefore investigated the developmental plasticity between human embryonic pancreatic cells and liver cells. Cells were isolated and expanded from 7–8-week-old human fetal pancreata (HFP) and were characterized for the absence and presence of pancreatic and hepatic markers. In vitro expanded HFP were treated with fibroblast growth factor 2 (FGF2) and dexamethasone (DX) to induce a liver phenotye in the cells. These treated cells in various passages were further studied for their capacity to be functional in hepatic parenchyma following retrorsine-induced injury in nude C57 black mice. Amylase- and EPCAM-positive-enriched cells isolated from HFP and treated with FGF2 and DX lost expression of pancreatic markers and gained a liver phenotype. Hepatic differentiation was based on the expression (both at the mRNA and protein level) of liver markers albumin and cytokeratin 19. When transplanted in vivo into nude mice treated with retrorsine, both cell types successfully engrafted and functionally differentiated into hepatic cells expressing human albumin, glycogen, dipeptidyl peptidase, and γ-glutamyltranspeptidase. These data indicate that human fetal pancreatic cells have a capacity to alter their gene expression profile in response to exogenous treatment with FGF2 and DX. It may be possible to generate an unlimited supply of hepatocytes in vitro for cell therapy.
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| 6. |
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| 7. |
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| 8. |
- Rofors, E., et al.
(författare)
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Response of a Li-glass/multi-anode photomultiplier detector to alpha-particles from Am-241
- 2019
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 929, s. 90-96
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Tidskriftsartikel (refereegranskat)abstract
- The response of a position-sensitive Li-glass scintillator detector to alpha-particles from a collimated Am-241 source scanned across the face of the detector has been measured. Scintillation light was read out by an 8 x 8 pixel multi-anode photomultiplier and the signal amplitude for each pixel has been recorded for every position on a scan. The pixel signal is strongly dependent on position and in general several pixels will register a signal (a hit) above a given threshold. The effect of this threshold on hit multiplicity is studied, with a view to optimize the single-hit efficiency of the detector.
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| 9. |
- Rofors, E., et al.
(författare)
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Response of a Li-glass/multi-anode photomultiplier detector to α-particles from 241 Am
- 2019
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 929, s. 90-96
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Tidskriftsartikel (refereegranskat)abstract
- The response of a position-sensitive Li-glass scintillator detector to α-particles from a collimated 241 Am source scanned across the face of the detector has been measured. Scintillation light was read out by an 8 × 8 pixel multi-anode photomultiplier and the signal amplitude for each pixel has been recorded for every position on a scan. The pixel signal is strongly dependent on position and in general several pixels will register a signal (a hit) above a given threshold. The effect of this threshold on hit multiplicity is studied, with a view to optimize the single-hit efficiency of the detector.
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| 10. |
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| 11. |
- Al Jebali, Ramsey, et al.
(författare)
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Recent Developments SoNDe High-Flux Detector Project
- 2018
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Ingår i: Recent Developments SoNDe High-Flux Detector Project.
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Konferensbidrag (refereegranskat)abstract
- New high-flux and high-brilliance neutron sources demand a higher count-rate capability in neutron detectors. In order to achieve that goal, the Solid-State Neutron Detector (SoNDe) project is developing a scintillation-based neutron detector. It will be capable of fully exploiting the available flux at small-angle neutron scattering (SANS) instruments at high brilliance sources, such as SKADI at the European Spallation Source (ESS). The read-out of the scintillator is based on a pixelized multi-anode PMT (MaPMT), where each pixel is treated separately. In addition to enabling higher achievable count-rates, one of the design goals was to develop a modular and scalable solution that can also be used in other instruments or even contexts, such as for laboratory setups. This has been achieved by combining the complete read-out electronics along with the MaPMT into modules that can be controlled and read-out individually via a network without additional any infrastructure. An overview of the present state of development and current test results is presented, highlighting the results of previously published project reports.
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| 12. |
- Greer, M., et al.
(författare)
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Lung transplantation after allogeneic stem cell transplantation: a pan-European experience
- 2018
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 51:2
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Tidskriftsartikel (refereegranskat)abstract
- Late-onset noninfectious pulmonary complications (LONIPCs) affect 6% of allogeneic stem cell transplantation (SCT) recipients within 5 years, conferring subsequent 5-year survival of 50%. Lung transplantation is rarely performed in this setting due to concomitant extrapulmonary morbidity, excessive immunosuppression and concerns about recurring malignancy being considered contraindications. This study assesses survival in highly selected patients undergoing lung transplantation for LONIPCs after SCT. SCT patients undergoing lung transplantation at 20 European centres between 1996 and 2014 were included. Clinical data pre- and post-lung transplantation were reviewed. Propensity score-matched controls were generated from the Eurotransplant and Scandiatransplant registries. Kaplan-Meier survival analysis and Cox proportional hazard regression models evaluating predictors of graft loss were performed. Graft survival at 1, 3 and 5 years of 84%, 72% and 67%, respectively, among the 105 SCT patients proved comparable to controls (p=0.75). Sepsis accounted for 15 out of 37 deaths (41%), with prior mechanical ventilation (HR 6.9, 95% CI 1.0-46.7; p<0.001) the leading risk factor. No SCT-specific risk factors were identified. Recurring malignancy occurred in four patients (4%). Lung transplantation <2 years post-SCT increased all-cause 1-year mortality (HR 7.5, 95% CI 2.3-23.8; p=0.001). Lung transplantation outcomes following SCT were comparable to other end-stage diseases. Lung transplantation should be considered feasible in selected candidates. No SCT-specific factors influencing outcome were identified within this carefully selected patient cohort.
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| 13. |
- Kanaki, K., et al.
(författare)
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Detector rates for the Small Angle Neutron Scattering instruments at the European Spallation Source
- 2018
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 13:7
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Tidskriftsartikel (refereegranskat)abstract
- Building the European Spallation Source (ESS), the most powerful neutron source in the world, requires significant technological advances at most fronts of instrument component design. Detectors are not an exception. The existing implementations at current neutron scattering facilities are at their performance limits and sometimes barely cover the scientific needs. At full operation the ESS will yield unprecedented neutron brilliance. This means that one of the most challenging aspects for the new detector designs is the increased rate capability and in particular the peak instantaneous rate capability, i.e. the number of neutrons hitting the detector per channel, pixel or cm2 at the peak of the neutron pulse. This paper focuses on estimating the incident and detection rates that are anticipated for the Small Angle Neutron Scattering (SANS) instruments planned for ESS. Various approaches are applied and the results thereof are presented.
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