| 1. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Stanaway, Jeffrey D., et al.
(författare)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Tidskriftsartikel (refereegranskat)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 3. |
- Micah, Angela E., et al.
(författare)
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Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
- 2021
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
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Forskningsöversikt (refereegranskat)abstract
- Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 4. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2021
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
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Tidskriftsartikel (refereegranskat)abstract
- Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
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| 5. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of neurological disorders, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016
- 2019
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 18:5, s. 459-480
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.Funding: Bill & Melinda Gates Foundation.
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| 6. |
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| 7. |
- Sepanlou, Sadaf G., et al.
(författare)
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The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017
- 2020
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Ingår i: The Lancet Gastroenterology & Hepatology. - 2468-1253. ; 5:3, s. 245-266
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Tidskriftsartikel (refereegranskat)abstract
- Background Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. Methods We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries. Findings In 2017, cirrhosis caused more than 1.32 million (95% UI 1.27-1.45) deaths (440000 [416 000-518 000; 33.3%] in females and 883 000 [838 000-967 000; 66.7%] in males) globally, compared with less than 899 000 (829 000-948 000) deaths in 1990. Deaths due to cirrhosis constituted 2.4% (2.3-2.6) of total deaths globally in 2017 compared with 1.9% (1.8-2.0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21.0 (19.2-22.3) per 100 000 population in 1990 to 16.5 (15.8-18-1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions for all years of the study period (32.2 [25.8-38.6] deaths per 100 000 population in 2017), and the high-income super-region had the lowest (10.1 [9.8-10-5] deaths per 100 000 population in 2017). The age-standardised death rate decreased or remained constant from 1990 to 2017 in all GBD regions except eastern Europe and central Asia, where the age-standardised death rate increased, primarily due to increases in alcohol-related liver disease prevalence. At the national level, the age-standardised death rate of cirrhosis was lowest in Singapore in 2017 (3.7 [3.3-4.0] per 100 000 in 2017) and highest in Egypt in all years since 1990 (103.3 [64.4-133.4] per 100 000 in 2017). There were 10.6 million (10.3-10.9) prevalent cases of decompensated cirrhosis and 112 million (107-119) prevalent cases of compensated cirrhosis globally in 2017. There was a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017. Cirrhosis caused by NASH had a steady age-standardised death rate throughout the study period, whereas the other four causes showed declines in age-standardised death rate. The age-standardised prevalence of compensated and decompensated cirrhosis due to NASH increased more than for any other cause of cirrhosis (by 33.2% for compensated cirrhosis and 54.8% for decompensated cirrhosis) over the study period. From 1990 to 2017, the number of prevalent cases snore than doubled for compensated cirrhosis due to NASH and more than tripled for decompensated cirrhosis due to NASH. In 2017, age-standardised death and DALY rates were lower among countries and territories with higher SDI. Interpretation Cirrhosis imposes a substantial health burden on many countries and this burden has increased at the global level since 1990, partly due to population growth and ageing. Although the age-standardised death and DALY rates of cirrhosis decreased from 1990 to 2017, numbers of deaths and DALYs and the proportion of all global deaths due to cirrhosis increased. Despite the availability of effective interventions for the prevention and treatment of hepatitis B and C, they were still the main causes of cirrhosis burden worldwide, particularly in low-income countries. The impact of hepatitis B and C is expected to be attenuated and overtaken by that of NASH in the near future. Cost-effective interventions are required to continue the prevention and treatment of viral hepatitis, and to achieve early diagnosis and prevention of cirrhosis due to alcohol-related liver disease and NASH.
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| 8. |
- Saxena, Richa, et al.
(författare)
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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:2, s. 142-148
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Tidskriftsartikel (refereegranskat)abstract
- Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).
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| 9. |
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| 10. |
- Gorasso, Vanessa, et al.
(författare)
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Burden of disease attributable to risk factors in European countries: a scoping literature review
- 2023
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Ingår i: Archives of Public Health. - 0778-7367 .- 2049-3258. ; 81:1
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Forskningsöversikt (refereegranskat)abstract
- Objectives: Within the framework of the burden of disease (BoD) approach, disease and injury burden estimates attributable to risk factors are a useful guide for policy formulation and priority setting in disease prevention. Considering the important differences in methods, and their impact on burden estimates, we conducted a scoping literature review to: (1) map the BoD assessments including risk factors performed across Europe; and (2) identify the methodological choices in comparative risk assessment (CRA) and risk assessment methods. Methods: We searched multiple literature databases, including grey literature websites and targeted public health agencies websites. Results: A total of 113 studies were included in the synthesis and further divided into independent BoD assessments (54 studies) and studies linked to the Global Burden of Disease (59 papers). Our results showed that the methods used to perform CRA varied substantially across independent European BoD studies. While there were some methodological choices that were more common than others, we did not observe patterns in terms of country, year or risk factor. Each methodological choice can affect the comparability of estimates between and within countries and/or risk factors, since they might significantly influence the quantification of the attributable burden. From our analysis we observed that the use of CRA was less common for some types of risk factors and outcomes. These included environmental and occupational risk factors, which are more likely to use bottom-up approaches for health outcomes where disease envelopes may not be available. Conclusions: Our review also highlighted misreporting, the lack of uncertainty analysis and the under-investigation of causal relationships in BoD studies. Development and use of guidelines for performing and reporting BoD studies will help understand differences, avoid misinterpretations thus improving comparability among estimates.
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| 11. |
- Hadfield, James, et al.
(författare)
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Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion
- 2017
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory Press. - 1088-9051 .- 1549-5469. ; 27:7, s. 1220-1229
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Tidskriftsartikel (refereegranskat)abstract
- Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in C. trachomatis.
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| 12. |
- Seth-Smith, Helena M. B., et al.
(författare)
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Whole-genome sequences of Chlamydia trachomatis directly from clinical samples without culture
- 2013
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory Press (CSHL). - 1088-9051 .- 1549-5469. ; 23:5, s. 855-866
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Tidskriftsartikel (refereegranskat)abstract
- The use of whole-genome sequencing as a tool for the study of infectious bacteria is of growing clinical interest. Chlamydia trachomatis is responsible for sexually transmitted infections and the blinding disease trachoma, which affect hundreds of millions of people worldwide. Recombination is widespread within the genome of C. trachomatis, thus whole-genome sequencing is necessary to understand the evolution, diversity, and epidemiology of this pathogen. Culture of C trachomatis has, until now, been a prerequisite to obtain DNA for whole-genome sequencing; however, as C trachomatis is an obligate intracellular pathogen, this procedure is technically demanding and time consuming. Discarded clinical samples represent a large resource for sequencing the genomes of pathogens, yet clinical swabs frequently contain very low levels of C trachomatis DNA and large amounts of contaminating microbial and human DNA. To determine whether it is possible to obtain whole-genome sequences from bacteria without the need for culture, we have devised an approach that combines immunomagnetic separation (IMS) for targeted bacterial enrichment with multiple displacement amplification (MDA) for whole-genome amplification. Using IMS-MDA ill conjunction with high-throughput multiplexed Illumina sequencing, we have produced the first whole bacterial genome sequences direct from clinical samples. We also show that this method can be used to generate genome data from nonviable archived samples. This method will prove a useful tool in answering questions relating to the biology of many difficult-to-culture or fastidious bacteria of clinical concern.
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| 13. |
- Ahamed, A. F. M. Jalal, 1976-
(författare)
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COVID-19-induced financial anxiety and state of the subjective well-being among the Bangladeshi middle class : the effects of demographic conditions
- 2022
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Ingår i: International Journal of Happiness and Development. - : InderScience Publishers. - 2049-2790 .- 2049-2804. ; 7:2, s. 142-158
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Tidskriftsartikel (refereegranskat)abstract
- In poverty-stricken countries, the middle or working-class usually falls out of focus in fiscal policy discussions, especially during crisis situations, such as the COVID-19 pandemic, in which governments seek to keep trade moving through grants and subsidies and work to sustain the poor. The current research aims to determine if the pandemic has had an impact on the subjective well-being (SWB) and financial anxiety (FAS) for a middle-class Bangladeshi sample, according to four critical demographic factors: gender, income, residency (capital or outside the capital), and job security. At the height of the pandemic (July 14–24, 2020), 129 respondents completed a self-reported survey questionnaire. The results indicate that although people appear to be happy in general, they are worried about their relationships. Women score lower on total well-being than men, as do those with household incomes below the average. People living outside the capital score marginally higher; people with well-secured jobs denote their higher well-being too. Furthermore, the FAS results indicate higher levels of anxiety among people with lower incomes and unsecured jobs. Therefore, the COVID-19 experience might inform future fiscal policies, including potential efforts to introduce universal job security insurance and financial counseling to employees after the pandemic.
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| 14. |
- Ahamed, A. F. M. Jalal, 1976-
(författare)
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Digital Transformation as a Means of Achieving SME Resilience During COVID-19 – A Systematic Review and Future Research Agenda
- 2024. - 1
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Ingår i: Small and Medium-Sized Enterprise (SME) Resilience. - : Springer Nature. - 9783031508356 - 9783031508387 - 9783031508363 ; , s. 17-32
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Bokkapitel (refereegranskat)abstract
- The Covid-19 pandemic had devastating effects on small and medium businesses (SME). The immediate shock, uncertainty, varying restrictions, and the risk to life disoriented the small and medium industries. In the last 4–5 years, we’ve seen small and medium businesses worldwide gradually return to their former state. Digital transformation is one of the tools used in this comeback effort. This topic has been the subject of several conceptual, empirical, and review studies. However, no systematic review has been conducted that examines digital transformation enablers and how digital transformation can lead to organizational resilience. This study aims to fill the gap. I conducted this systematic review following the PRISMA guidelines. On the basis of the 37 studies that met the inclusion criteria, I identified two clusters of enablers (strategic orientations, capabilities, and capacities) as well as six mediating strategies (frugal innovation, organizational agility, strategic agile process, dynamic strategic planning, social entrepreneurship and competitive intelligence, and sustainable business processes) of digital transformation on SME resilience. A consolidated conceptual model was developed based on the findings of this review. Scholars will be able to use these results to understand the knowledge boundary and develop effective strategies for promoting the resilience of SME’s.
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| 15. |
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| 16. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Driving performance in exporter-importer exchange relationships : The efficacy of interorganizational trust as a response to exchange risks
- 2023
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Ingår i: Cogent Business and Management. - : Taylor & Francis Group. - 2331-1975. ; 10:3
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Tidskriftsartikel (refereegranskat)abstract
- Drawing on the transaction cost analysis perspective, this study examines how three types of exchange risks influence performance in exporter-importer exchange relationships. These risks include cultural distance, which gives rise to behavioral uncertainty and its associated measurement problem; market turbulence, a dimension of environmental uncertainty that gives rise to an adaptation problem; and transaction-specific assets, representing a safeguarding problem. The conceptual model assesses how an informal governance mechanism, inter-organizational trust, responds to these three exchange risks and, in doing so, fosters relational and export performance. Based on a structural equation model conducted in PLS, our findings indicate that cultural distance relates positively to inter-organizational trust, and market turbulence positively relates to exporter-specific assets. Exporter-specific assets and inter-organizational trust were found to have a reciprocal relationship. This research also confirms the mediating role of relational performance concerning the effects of exporter-specific assets and inter-organizational trust on financial export performance.
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| 17. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Effect of distance and communication climate on export performance : The mediating role of relationship quality
- 2013
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Ingår i: Journal of Global Marketing. - : Informa UK Limited. - 0891-1762 .- 1528-6975. ; 26:5, s. 284-300
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Tidskriftsartikel (refereegranskat)abstract
- The authors explore how distance and the communication climate perceived by exporters influence export performance both directly and as mediated by relationship quality. The ready-made garments industry in Bangladesh yielded 185 responses. A mediation model was tested using structural equation modeling, applying partial least squares techniques. The results show that distance is negatively related to communication climate and relationship quality; relationship quality mediates the distance–export performance relationship, whereas communication climate is positively associated with relationship quality and export performance, and a full mediating role of relationship quality is found in the communication climate–export performance relationship. A strong positive relationship between relationship quality and export performance is also identified. The managerial implication of the study includes that with better relationship strength, it is possible to neutralize the negative impact of distance on export performance. The implications and limitations are also discussed.
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| 18. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Facebook usage intensity and compulsive buying tendency : The mediating role of envy, self-esteem, and self-promotion and the moderating role of depression
- 2021
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Ingår i: International Journal of Electronic Marketing and Retailing. - : InderScience Publishers. - 1741-1025 .- 1741-1033. ; 12:1, s. 69-88
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Tidskriftsartikel (refereegranskat)abstract
- While Facebook usage intensity (FBUI) and compulsive buying tendency (CBT) have individually received increased research attention, very little is known about the mechanisms through which FBUI affects CBT. This study proposes and tests a multiple mediation model in which the effect of FBUI on CBT is mediated by personality characteristics (envy, self-esteem, and self-promotion). The study also explores the moderating effect of depression on these mediated relationships. The results of a self-administered survey of 393 Bangladeshi adults support the proposed moderated mediation model. The effect of FBUI on CBT is mediated by envy and self-esteem independently. The FBUI indirectly affects CBT through serial mediators: 1) envy and self-esteem; 2) envy and self-promotion. These serial mediating effects are moderated by depression. The theoretical and practical implications of these findings are discussed.
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| 19. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Financial anxiety : a systematic review
- 2024
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Ingår i: International Journal of Bank Marketing. - : Emerald Group Publishing Limited. - 0265-2323 .- 1758-5937.
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Forskningsöversikt (refereegranskat)abstract
- Purpose: Financial anxiety has become a global concern and a growing research area with significant potential to contribute to the behavioral and personal finance literature. Despite this, the literature is fragmented and inconsistent. Prior studies vary greatly in the breadth of definitions and measures of financial anxiety. There has been no systematic evaluation of literature on financial anxiety antecedents, consequences, and coping strategies. This systematic review fills this gap. Design/methodology/approach: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched Scopus and Web of Science and identified 55 eligible studies published between 2009 and 2024. Findings: Financial anxiety is defined and measured differently in different research domains. We identified several antecedents, including socio-demographic factors (e.g. gender, age, ethnicity, income, employment, racial background, and language proficiency), personality traits, compulsive and impulsive buying behavior, depression or other mental issues, family health issues, and the COVID-19 pandemic and consequences of financial anxiety, including psychological and psychic health, societal and personal relations, financial behavior and well-being, and job-related outcomes. In addition, the literature presents six financial anxiety coping strategies (self-imposed coping mechanisms, spiritual and theological resources, increased financial capability, social and family support, seeking professional help, and language proficiency training). Several future research directions are presented. Originality/value: This review represents the first systematic compilation and evaluation of the research findings on financial anxiety.
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| 20. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Interconnectedness of trust-commitment-export performance dimensions : a model of the contingent effect of calculative commitment
- 2022
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Ingår i: Cogent Business & Management. - : Taylor & Francis Group. - 2331-1975. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- This research on relationship marketing aims to revisit and reposition different foci of trust, commitment, and performance perception in the export/import relationships and explore the interconnectedness effects. We have collected self-reported survey questionnaire responses from 142 non-oil exporters in Ecuador. The data were analyzed with SmartlPls 3.0 software. We found that calculative commitment negatively moderates inter-organizational trust and affective commitment relationships. The other significant findings include the indirect relationship (mediating effect) of affective commitment to financial export performance through relationship export performance. With these novel contributions, we also identify some expected relationships- as both interpersonal and inter-organizational trust positively affects affective commitment, and relationship export performance significantly predicts financial export performance. Cross-sectional data collection and responses from one side of the export-import dyad are one of this research’s limitations. However, they are not uncommon in export marketing literature. Giving a justified position of different dimensions of trust and commitment in the export-import equation is the novelty of this scholarship. Clarifying the affective commitment and export performance relationship is another contribution of this research. Nevertheless, the dimensional views of trust and commitment re-established some known assumptions in a less researched country setting should also be considered a contribution.
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| 21. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Online Retailer Reputation, Satisfaction, and Trust as Catalysts in the Consumer Perceptions of Ethics on Online Retailers and Repurchase Intention
- 2021
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Ingår i: International Journal of E-Adoption (IJEA). - : IGI Global. - 1937-9633 .- 1937-9641. ; 13:2, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- This research investigates the effect of consumer perceptions regarding the ethics of online retailers (CPEOR) on repurchase intention through reputation, satisfaction, and trust. The authors performed structural equation model analysis with SmartPLS on a sample of 458 responses collected from Vietnamese consumers. They found that CPEOR has a significant positive effect on reputation, satisfaction, and trust. As expected, trust and satisfaction directly predict repurchase intention; however, reputation does not directly follow this pattern. Instead, two prosocial constructs, namely trust and satisfaction, channel the effect of reputation on repurchase intention. Contrary to the conventional understanding that a favourable reputation will predict higher consumer trust, they found a negative correlation between these two factors. The managerial and theoretical contributions of the research and direction for future research are highlighted.
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| 22. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Retirement Planning : A Moderated Mediation Model of Cognitive Beliefs, Retirement Planning Attitude, and Money Availability
- 2024
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Ingår i: Financial Services Review. - : Academy of Financial Services. - 1057-0810 .- 1873-5673. ; 32:2, s. 77-93
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Tidskriftsartikel (refereegranskat)abstract
- Retirement planning has been extensively studied in developed countries; however, it received scant scholarly attention in developing nations. Thus, this study examines the role of cognitive factors in retirement planning intentions in the context of a developing country, focusing on financial risk tolerance and self-efficacy within the cognitive appraisal theory framework, considering the mediating role of retirement planning attitudes and the moderating impact of financial resource availability. A survey was conducted in Dhaka, Bangladesh, with 301 valid responses analyzed using a Partial Least Squares Structural Equation Modeling (PLS-SEM) approach. Findings reveal that retirement planning attitudes mediate the relationship between cognitive factors and retirement planning intentions. Interestingly, risk tolerance negatively impacts retirement planning intentions through attitudes, while financial self-efficacy shows a positive influence. Furthermore, the availability of financial resources moderates these relationships, indicating that retirement planning attitudes significantly influence intentions when financial resource availability is low. This research contributes to the understanding of retirement planning in a developing country context, highlighting the importance of cognitive factors and financial resources. It suggests that tailored retirement planning strategies should consider individual financial conditions and cognitive beliefs. The insights are valuable for policymakers and financial advisors, particularly in developing nations.
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| 23. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Revisiting the Trust–Commitment and Export Performance Link : A Qualitative Comparative Analysis (QCA) Approach
- 2020
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Ingår i: Re-imagining Diffusion and Adoption of Information Technology and Systems: A Continuing Conversation. - Cham : Springer. - 9783030648602 - 9783030648619 ; , s. 556-568
-
Konferensbidrag (refereegranskat)abstract
- This research revisits the role of different foci of trust (interpersonal and inter-organizational), commitment (affective and calculative) and relationship lengths (inter-organizational and interpersonal) then on export relationship performance. 142 Ecuadorian non-oil exporters completed a self-administered questionnaire. This study applies fuzzy-set qualitative comparative analysis (fsQCA) and the findings help to re-establish the need for both trust dimensions and affective commitment in exporter–importer relationships. This research found three possible configurations of achieving high export relationship performance. The managerial implications noted that export managers should nurture trust and affective commitment to ensure improved relationship performance. This research is one of the very few studies to investigate the role of commitment and trust by taking a complexity theoretical turn. Exploring the causation of the relationship lengths on relationship performance also represents a novel contribution.
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| 24. |
- Ahamed, A. F. M. Jalal, 1976-
(författare)
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The effect of demographic characteristics on considerations of future consequences and compulsive buying and their interlinks
- 2022
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Ingår i: International Journal of Business and Emerging Markets. - : InderScience Publishers. - 1753-6219 .- 1753-6227. ; 14:3, s. 279-295
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to examine the impacts of demographic variables (gender, age, and income) on consideration of future consequences (CFCs) and compulsive buying tendencies (CBT). It also investigates if and to what extent the demographic characteristics might influence the effect of CFC on CBT. Data for this study were collected from 394 adult respondents using a self-administered survey. The structural equation model in AMOS reveals that consideration of future (CFC-F) has a significant negative effect on CBT, whereas consideration of immediate (CFC-I) has no significant effect. In addition, the multi-group analysis found that the influence of CFC on CBT does not change across genders, yet it varies with income and age differences. These novel insights into consumer behaviour have implications for both research and practice.
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| 25. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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The link between export relationship quality, performance and expectation of continuing the relationship : A South Asia exporters’ perspective
- 2015
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Ingår i: International Journal of Emerging Markets. - : Emerald Group Publishing Limited. - 1746-8809 .- 1746-8817. ; 10:1, s. 16-31
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - The purpose of this study is threefold: to investigate how relationship quality affects export performance; to see if and to what extent export performance affects exporter satisfaction; and to determine whether exporter satisfaction ultimately affects the expectation of continuing the export-import relationship in an emerging market. Design/methodology/approach - The paper reports the findings of a survey of 185 respondents from the ready-made garments industry in Bangladesh chosen from a convenience sample. The responding exporters were located in Dhaka city or nearby areas. The data were analyzed using the partial least squares technique. Findings - The results support four out of five hypotheses, indicating that there is a significant relationship between exporter relationship quality and financial and strategic export performance. Additionally, a positive relationship between financial export performance and exporter satisfaction and between exporter satisfaction and the expectation of continuing the relationship are shown. No significant relationship between strategic export performance and exporter satisfaction is found. Practical implications - The findings have practical implications for managers and policy-makers interested in developing effective strategies for building and maintaining high quality export-import relationships, especially in the context of an emerging market. Originality/value - In order to accomplish the research goal, the main constructs from two influential streams of literature - social exchange theory and the disconfirmation of expectation theory - are utilized. This is new in the context of an emerging economy perspective.
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| 26. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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The Mediating Effect of Relationship Quality on the Transaction Cost-Export Performance Link : Bangladeshi Exporters' Perspectives
- 2015
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Ingår i: Journal of Relationship Marketing. - : Informa UK Limited. - 1533-2667 .- 1533-2675. ; 14:2, s. 152-169
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Tidskriftsartikel (refereegranskat)abstract
- This study explores how relationship quality might mediate the link between transaction cost variables and export performance. In the proposed conceptual model, relationship-specific assets and uncertainty affect export performance both directly and through relationship quality; survey data from 185 exporting organizations in Bangladesh provide the test of this model. This article thus proposes that transaction cost economics and relational exchange theories are complementary rather than competing theories. These conclusions arise because this study accounts for not only the direct effect of asset specificity and uncertainty on export performance but also their indirect effects through relationship quality, which have not been empirically tested or clarified previously.
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| 27. |
- Ahamed, A. F. M. Jalal, 1976-
(författare)
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The Pursuit of Subjective Well-Being Through Financial Well-Being, Relationship Quality, and Spiritual Well-Being : A Configuration Approach with Fuzzy-Set Qualitative Comparative Analysis (fsQCA)
- 2024
-
Ingår i: Journal of Family and Economic Issues. - : Springer. - 1058-0476 .- 1573-3475.
-
Tidskriftsartikel (refereegranskat)abstract
- Individuals’ subjective well-being is influenced by their financial well-being, family relationship quality, spiritual well-being, gender, and age. However, our knowledge of potential associations between these factors is limited, especially in non-western developing countries. Further, human thinking’s complexity, interconnectedness, and asymmetry fit nicely with subjective well-being conceptualizations. Therefore, this research is one of the very first studies from a typical Asian country that conceptualizes subjective well-being asymmetrically. The primary objective of this study was to determine which combinations of these factors resulted in higher or lower subjective well-being. We used a self-administered questionnaire to survey 250 married working people in Bangladesh’s capital city. The factor combinations are identified with a fuzzy-set qualitative comparative analysis (fsQCA). Despite not finding any necessary condition for high or low subjective well-being, the analysis identifies two equifinal combinations of high subjective well-being and four combinations of low subjective well-being. In Asian cultures, where family bonds and spiritual well-being are feared to be declining, the combination of identified configurations re-emphasizes the importance of family relationship quality and spiritual well-being. Using a configurational approach, the findings contribute to the literature on subjective well-being and family relationships by explaining how different combinations of factors determine an individual's well-being. Additionally, this has important implications for policymakers and society as a whole.
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| 28. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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Understanding Vietnamese Consumer Intention to Use Online Retailer Websites : Application of the Extended Technology Acceptance Model
- 2020
-
Ingår i: International Journal of E-Adoption (IJEA). - : IGI Global. - 1937-9633 .- 1937-9641. ; 12:2
-
Tidskriftsartikel (refereegranskat)abstract
- This study examines the applicability of an extended technology acceptance model (TAM) that incorporates trust, perceived risk, and self-enhancement as antecedents to the TAM constructs. Data collected from 299 Vietnamese online consumers, through a self-administered survey, were entered into a structural equation model using AMOS 23 to establish causality. The results partially confirm the applicability of TAM to the online shopping intentions of Vietnamese consumers, though contrary to expectations, perceived ease of use does not predict behavioral intentions. Trust and self-enchantment fit well with the TAM; the inclusion of perceived risk as an antecedent is questionable. The findings offer new opportunities for explaining TAM theory in light of Schwartz’s value dimensions. This article thus concludes with a discussion of the research contributions and implications.
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| 29. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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What Drives High Penetration Rates of Social Media? : A Qualitative Comparative Analysis across Countries
- 2022
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Ingår i: Journal of Business and Management. - : College of Management, National Chung Cheng University. - 1535-668X. ; 28:1, s. 101-130
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose – This study examines the drivers of country-level high Social Media Penetration (SMP) rate by considering the concurrent causation of cultural and socio-economic conditions.Method – Ninety-four countries across continents were analyzed using the set-theoretic configurational approach fuzzy set Qualitative Comparative Analysis (fsQCA 3.0).Findings – Results reveal that the adult literacy rate is the necessary condition and found four causal combinations for high SMP.Limitations – Limitations related to using secondary data at a single point and including only two socio-economic conditions in the design are recognized.Contributions to literature- This study is believed to be among the first to use QCA for testing and providing evidence of SMP as an outcome of cultural and social-economic conditions. It contributes to theory by advancing our knowledge of what combination of cultural and social-economic factors would result in high or low SMP.Practical Implications- This study provides managerial implications for both digital marketers and social media technology designers and suppliers. With the increasing connectedness in this digital age, global marketers should be more mindful and respectful of the expectations of their customers around the world and shape their decision-making processes accordingly. Social media can be a very effective tool to help global marketers learn about other cultures, overcome adjustment challenges, and establish as well as maintain relationships. All these can accelerate the integration into the host culture during their adaptation (Sawyer and Chen, 2012). Our study provides greater insights of what combination of cultural and social-economic conditions may facilitate or inhibit the adoption of their platforms. Our findings can also help social media managers in their global targeting initiatives. Customized social media programs can be designed to target a specific cluster of countries according to usage patterns based on technological capability and social norms.Social implications- More and more reports have been published to attest to the economic and social impact of social media. Despite the rapid growing influence on our societies, social media remains a relatively untapped source of information to catalyze policy action and social change (Yeung, 2018). Our study offers insight for social policy making by identifying multiple paths to enhance social media’s penetration as decision makers increasingly realize its potential and long-term benefits resulted from continued use of social media analytics.Originality- This study is believed to be among the first to use QCA for testing and providing evidence of SMP as an outcome of cultural and social-economic conditions. It identifies four complex antecedent paths that are responsible for high SMP, allowing for a more comprehensive explanation of our outcome of interest.
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| 30. |
- Ahamed, A. F. M. Jalal, 1976-, et al.
(författare)
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What Drives Importer Opportunism? : Learning from a Developing Country in Latin America
- 2021
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Ingår i: Journal of Global Marketing. - : Taylor & Francis. - 0891-1762 .- 1528-6975. ; 34:2, s. 146-164
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Tidskriftsartikel (refereegranskat)abstract
- This research integrates transaction cost and relational exchange theories to depict a more nuanced explanation of exporter-importer exchange relationships when exporters operate from a developing country. Our study examines whether exporters’ investments in specific assets directly influence perceived importer opportunism, or whether these perceptions are driven by the mediating effects of interpersonal and inter-organizational trust and power. Contrary to the general transaction cost argument, we did not find any direct effect of exporter specific assets on perceived importer opportunism. Instead, we found that perceived importer power and exporter inter-organizational trust jointly mediate the exporter specific assets – perceived importer opportunism relationship. By incorporating a dimensional view of trust, we help to resolve conflicting theoretical specifications and empirical results found in the extant literature.
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| 31. |
- Aljaibeji, Hayat, et al.
(författare)
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Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells
- 2019
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Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1 (832/13) cells. Microarray and RNA sequencing data showed that PLCXD3 is among the highly expressed PI-PLCs in human islets and INS-1 (832/13) cells. Expression of PLCXD3 was reduced in human diabetic islets, correlated positively with Insulin and GLP1R expression and inversely with the donor's body mass index (BMI) and glycated hemoglobin (HbA1c). Expression silencing of PLCXD3 in INS-1 (832/13) cells was found to reduce glucose-stimulated insulin secretion (GSIS) and insulin content. In addition, the expression of Insulin, NEUROD1, GLUT2, GCK, INSR, IRS2, and AKT was downregulated. Cell viability and apoptosis rate were unaffected. In conclusion, our data suggest that low expression of PLCXD3 in pancreatic β-cells associates with downregulation of the key insulin signaling and insulin biosynthesis genes as well as reduction in glucose sensing.
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| 32. |
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| 33. |
- Austin, Thomas R, et al.
(författare)
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Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures.
- 2024
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Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 1523-4681. ; 39:2, s. 139-149
-
Tidskriftsartikel (refereegranskat)abstract
- Hip fractures are associated with significant disability, high cost, and mortality. However, the exact biological mechanisms underlying susceptibility to hip fractures remain incompletely understood. In an exploratory search of the underlying biology as reflected through the circulating proteome, we performed a comprehensive Circulating Proteome Association Study (CPAS) meta-analysis for incident hip fractures. Analyses included 6430 subjects from two prospective cohort studies (Cardiovascular Health Study and Trøndelag Health Study) with circulating proteomics data (aptamer-based 5K SomaScan version 4.0 assay; 4979 aptamers). Associations between circulating protein levels and incident hip fractures were estimated for each cohort using age and sex-adjusted Cox regression models. Participants experienced 643 incident hip fractures. Compared with the individual studies, inverse-variance weighted meta-analyses yielded more statistically significant associations, identifying 23 aptamers associated with incident hip fractures (conservative Bonferroni correction 0.05/4979, P<1.0×10-5). The aptamers most strongly associated with hip fracture risk corresponded to two proteins of the growth hormone/insulin growth factor system (GHR and IGFBP2), as well as GDF15 and EGFR. High levels of several inflammation-related proteins (CD14, CXCL12, MMP12, ITIH3) were also associated with increased hip fracture risk. Ingenuity pathway analysis identified reduced LXR/RXR activation and increased acute phase response signaling to be overrepresented among those proteins associated with increased hip fracture risk. These analyses identified several circulating proteins and pathways consistently associated with incident hip fractures. These findings underscore the usefulness of the meta-analytic approach for comprehensive CPAS in a similar manner as has previously been observed for large-scale human genetic studies. Future studies should investigate the underlying biology of these potential novel drug targets.
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| 34. |
- Fam, Kim-Shyan, et al.
(författare)
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Do Muslim generation cohorts differ in purchase intention? - The case of Islamic financial products
- 2020
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Ingår i: Journal of Halal Service Research. - : MAG Scholar. Marketing in Asia Group. - 2703-2299 .- 2703-2302. ; 1:1
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to examine how and to what extent the purchase intention for various Islamic Financial Products (IFPs) would vary among various generational cohorts depending on their cohort experiences and the nature of different categories of IFPs. The data to examine our hypotheses comes from 954 Muslim consumers from five major metropolitan cities in Bangladesh. We found that significant differences in purchase intention of Islamic deposit and insurance products exist where each succeeding generation has less purchase intention than the previous generation. Considerable evidence exists that Muslims' religiosity impacts their personal and consumption decisions with the idea that their extent of perceived religiosity influences their behavior. Besides the theoretical contributions, our findings have several implications for the managers.
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| 35. |
- Fowler, Scott, et al.
(författare)
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Evaluation and prospects from a measurement campaign on real multimedia traffic in LTE vs. UMTS
- 2014
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Ingår i: Wireless Communications, Vehicular Technology, Information Theory and Aerospace Electronic Systems (VITAE'14), IEEE 4th International Conference on. - : IEEE Press. ; , s. 1-5
-
Konferensbidrag (refereegranskat)abstract
- The LTE standard has been developed for high-bandwidth mobile access for today’s data-heavy applications. With broadband cellular available already from the UMTS system, users are expecting the LTE network to provide high quality communication. To ensure the quality and correctness of complex systems of LTE, it is important to evaluate the behavior of traffic on a LTE network in relation to UMTS. In this paper, LTE and UMTS measurements on video traffic were performed in a real environment, allowing for greater development, and understanding of network traffic performance.
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| 36. |
- Gunnarsson, Helena E. M., 1975-, et al.
(författare)
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Different pain variables could independently predict anxiety and depression in subjects with chronic musculoskeletal pain
- 2021
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Ingår i: Scandinavian Journal of Pain. - : Walter de Gruyter GmbH. - 1877-8860 .- 1877-8879. ; 21:2, s. 274-282
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Chronic, clinical pain states are often accompanied by distress such as anxiety and depression. The aim of this study was to determine if certain clinical pain variables could predict the level of anxiety and depression in subjects with musculoskeletal pain.Methods: Two multiple linear regression analyses were conducted on a sample consisting of 189 subjects with clinical pain with the independent pain variables of pain intensity, the influence of pain on daily activities, pain persistence, pain duration, and the number of pain locations. The dependent variables measured anxiety and depression, respectively.Result: Two statistically significant models were found, where the predicted variables accounted for 37.0% of the variability in the anxiety levels and 43.7% of the variability in the depression levels. The independent variable, the influence of pain on daily activities, significantly predicted the level of anxiety. The variables, the influence of pain on daily activities and the number of pain locations, significantly predicted the levels of anxiety and depression.Conclusions: This study showed that two different independent variables, the influence of pain on daily activities and the number of pain locations, significantly predicted the levels of depression. The predictor, the influence of pain on daily activities, significantly predicted the levels of anxiety. The knowledge gained about which specific pain variables are more likely to coexist with anxiety and depression in clinical pain states could be important in implementing holistic treatment plans for chronic pain.
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| 37. |
- Hachim, Mahmood Y., et al.
(författare)
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An integrative phenotype–genotype approach using phenotypic characteristics from the UAE national diabetes study identifies HSD17B12 as a candidate gene for obesity and type 2 diabetes
- 2020
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Ingår i: Genes. - : MDPI AG. - 2073-4425. ; 11:4
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Tidskriftsartikel (refereegranskat)abstract
- The United Arab Emirates National Diabetes and Lifestyle Study (UAEDIAB) has identified obesity, hypertension, obstructive sleep apnea, and dyslipidemia as common phenotypic characteristics correlated with diabetes mellitus status. As these phenotypes are usually linked with genetic variants, we hypothesized that these phenotypes share single nucleotide polymorphism (SNP)-clusters that can be used to identify causal genes for diabetes. Materials and We explored the National Human Genome Research Institute-European Bioinformatics Institute Catalog of Published Genome-Wide Association Studies (NHGRI-EBI GWAS) to list SNPs with documented association with the UAEDIAB-phenotypes as well as diabetes. The shared chromosomal regions affected by SNPs were identified, intersected, and searched for Enriched Ontology Clustering. The potential SNP-clusters were validated using targeted DNA next-generation sequencing (NGS) in two Emirati diabetic patients. RNA sequencing from human pancreatic islets was used to study the expression of identified genes in diabetic and non-diabetic donors. Eight chromosomal regions containing 46 SNPs were identified in at least four out of the five UAEDIAB-phenotypes. A list of 34 genes was shown to be affected by those SNPs. Targeted NGS from two Emirati patients confirmed that the identified genes have similar SNP-clusters. ASAH1, LRP4, FES, and HSD17B12 genes showed the highest SNPs rate among the identified genes. RNA-seq analysis revealed high expression levels of HSD17B12 in human islets and to be upregulated in type 2 diabetes (T2D) donors. Our integrative phenotype-genotype approach is a novel, simple, and powerful tool to identify clinically relevant potential biomarkers in diabetes. HSD17B12 is a novel candidate gene for pancreatic β-cell function.
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| 38. |
- Higginbottom, Gina M. A., et al.
(författare)
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An ethnographic study of communication challenges in maternity care for immigrant women in rural Alberta
- 2015
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Ingår i: Midwifery. - : Elsevier. - 0266-6138 .- 1532-3099. ; 31:2, s. 297-304
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Tidskriftsartikel (refereegranskat)abstract
- Backgroundmany immigrant and ethno-cultural groups in Canada face substantial barriers to accessing health care including language barriers. The negative consequences of miscommunication in health care settings are well documented although there has been little research on communication barriers facing immigrant women seeking maternity care in Canada. This study identified the nature of communication difficulties in maternity services from the perspectives of immigrant women, health care providers and social service providers in a small city in southern Alberta, Canada.Methodsa focused ethnography was undertaken incorporating interviews with 31 participants recruited using purposive and snowball sampling. A community liaison and several gatekeepers within the community assisted with recruitment and interpretation where needed (n=1). All interviews were recorded and audio files were transcribed verbatim by a professional transcriptionist. The data was analysed drawing upon principles expounded by Roper and Shapira (2000) for the analysis of ethnographic data, because of (1) the relevance to ethnographic data, (2) the clarity and transparency of the approach, (3) the systematic approach to analysis, and (4) the compatibility of the approach with computer-assisted qualitative analysis software programs such as Atlas.ti (ATLAS.ti Scientific Software Development GmbH, Germany). This process included (1) coding for descriptive labels, (2) sorting for patterns, (3) identification of outliers, (4) generation of themes, (5) generalising to generate constructs and theories, and (6) memoing including researcher reflections.Findingsfour main themes were identified including verbal communication, unshared meaning, non-verbal communication to build relationships, and trauma, culture and open communication. Communication difficulties extended beyond matters of language competency to those encompassing non-verbal communication and its relation to shared meaning as well as the interplay of underlying pre-migration history and cultural factors which affect open communication, accessible health care and perhaps also maternal outcomes.Conclusionthis study provided insights regarding maternity health care communication. Communication challenges may be experienced by all parties, yet the onus remains for health care providers and for those within health care management and professional bodies to ensure that providers are equipped with the skills necessary to facilitate culturally appropriate care.
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| 39. |
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| 40. |
- Lee, Youngsu, et al.
(författare)
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An International Study of Culture, Gender, and Moral Ideology on Sales Ethics Evaluations : How Should Educators Respond?
- 2018
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Ingår i: Journal of Marketing Education. - : Sage Publications. - 0273-4753 .- 1552-6550. ; 40:3, s. 196-210
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Tidskriftsartikel (refereegranskat)abstract
- While international demand for sales positions is growing, negative sales stereotypes, partially fueled by ethical abuses in the sales arena, are prevalent and may dissuade students from pursuing sales careers. To help combat the situation globally, educators must develop and utilize effective sales ethics pedagogies. The first step involves understanding cross-cultural sales ethics perspectives. A convenience sample is drawn from five countries (United States, France, Germany, Indonesia, and New Zealand), and the Personal Selling Ethics Scale (PSE-2) is successfully used to examine culturally specific and gender-based evaluation differences. Gender-based ethical perspectives are of particular interest due to the growing gender diversity within sales professions. The study finds that cultural traditionalism/secularism and individualism/collectivism affect sales ethics evaluations. Likewise, gender and moral ideology affect evaluations. Women are more sensitive to ethical misconduct than men, and absolutist are more sensitive than exceptionists, situationists, and subjectivists. Specific pedagogical recommendations are provided
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| 41. |
- Limbu, Yam B., et al.
(författare)
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What Influences Green Cosmetics Purchase Intention and Behavior? : A Systematic Review and Future Research Agenda
- 2023
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 15:15
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Forskningsöversikt (refereegranskat)abstract
- The green cosmetics industry has witnessed significant growth over the last few years. Simultaneously, scholarly interest in the area has grown. However, overall, the evidence is inconsistent. Despite the growing literature, no systematic review has been carried out to summarize and synthesize the empirical studies that have examined factors associated with green cosmetics purchase intention (GCPI) and green cosmetics purchase behavior (GCPB). This study aims to fill this gap. We conducted this systematic review following the PRISMA guidelines. From forty-eight studies that met the inclusion criteria, we identified ten major themes that were significantly associated with GCPI and GCPB. The most frequently demonstrated determinants were the theory of planned behavior components (attitude, subjective norms, and perceived behavioral control), followed by marketing mix, consumer consciousness concerns, consumer values, brand-related attributes, experience and knowledge, self-efficacy, and perceived barriers. In addition, we identified several gaps that could be addressed through future research. These results will help scholars understand the knowledge boundary and assist marketers in developing effective strategies for promoting green cosmetics.
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| 44. |
- Prokopenko, Inga, et al.
(författare)
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A Central Role for GRB10 in Regulation of Islet Function in Man.
- 2014
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father.
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| 45. |
- Sharma, Swati, et al.
(författare)
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Modelling Consumer’s Mobile Wallet App Adoption and Its Continuous Usage : The Case of India
- 2023
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Ingår i: Digital Economy Post COVID-19 Era. - Singapore : Springer. - 9789819901968 - 9789819901975 ; , s. 213-232
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Konferensbidrag (refereegranskat)abstract
- Mobile usage and internet consumption have marked tremendous growth in the last decade. The adoption of mobile technology has gained the attention of researchers, and few studies have been carried out to understand the factors of mobile technology adoption. This study aims to understand the factors affecting mobile wallet app adoption among Indian consumers. The study explores the factors that impact wallet app adoption and the mediating role of satisfaction between wallet app adoption and its continuous usage. A conceptual model was developed based on the unified theory of acceptance and use of technology (UTAUT) framework and tested on 424 responses collected from India’s Delhi NCR capital region. The original UTAUT framework has been extended by adding factors: enjoyment, aesthetics, incentives, and trust. The hypothesized relationships were analysed by using the structural equation modelling (SEM) method. Geographical limitations, the younger population as a prominent respondent in the study, and longitudinal study were reported as a few of the limitations of the study. The findings of the study would help the mobile wallet app developers and providers by providing valuable insights which in turn can be implemented by them to frame their strategies for increased adoption of the wallet apps.
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| 46. |
- Taneera, Jalal, et al.
(författare)
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Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction
- 2020
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Ingår i: Molecular and Cellular Endocrinology. - : Elsevier BV. - 0303-7207. ; 499
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Tidskriftsartikel (refereegranskat)abstract
- The expression and functional impact of most expression orphan G-protein coupled receptors (GPCRs) in β-cell is not fully understood. Microarray expression indicated that 36 orphan GPCRs are restricted in human islets, while 55 receptors overlapped between human islets and INS-1 cells. GPR183 showed higher expression in diabetic compared to non-diabetic human islets. GPR183 expression co-localized with β-cells while it was lacking in α-cells in human islets. The GPR183 agonist (7α-25-DHC) potentiated insulin secretion and protected against glucotoxicity-induced β-cell damage in human islets. Silencing of GPR183 in INS-1 cells decreased the expression of proinsulin genes, Pdx1, Mafa and impaired insulin secretion with a concomitant decrease in cAMP generation. Cultured INS-1 cells with 7α-25-DHC were associated with increased proliferation and expression of GPR183, INS2, PDX1, NeuroD, and INSR. In conclusion, the beneficial impact of GPR183 activation on β-cell function makes it a potential therapeutic target to prevent or reverse β-cell dysfunction.
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| 47. |
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