| 1. |
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| 2. |
- Andersson, Hanna, et al.
(författare)
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Natur på skolgården för lärande, hälsa och hållbarhet
- 2024. - 2024
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Rapport (populärvet., debatt m.m.)abstract
- Gröna och artrika utemiljöer främjar barns och ungas välbefinnande och kunskap, bådegenom hälsofördelar kopplade till biologisk mångfald och genom att skapa förutsättningarför lek och lärande om natur och miljöfrågor. Skolgården skulle kunna bidra till allt detta,men är idag i hög grad en outnyttjad plats för biologisk mångfald och klimatanpassningav städer. I denna policy brief presenteras huvudsakliga motiv och möjliga åtgärder för attutveckla gröna miljöer och biologisk mångfald på skolgårdar och förskolegårdar.
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| 3. |
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| 5. |
- Thor, Anna, et al.
(författare)
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Primary retroperitoneal lymph node dissection as treatment for low-volume metastatic seminoma in a population-based cohort : the Swedish Norwegian testicular cancer group experience
- 2024
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Ingår i: European Urology Open Science. - : Elsevier. - 2666-1691 .- 2666-1683. ; 65, s. 13-19
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Tidskriftsartikel (refereegranskat)abstract
- Background and objective: There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopathy.Methods: Sixty-two seminoma patients in Norway and Sweden were included in the cohort from 2019 to 2022. Patients with lymphadenopathy ≤3 cm, having primary clinical stage (CS) IIA/B or CS I with a relapse, were operated with uni- or bilateral template RPLND, open or robot assisted. The outcome measures included surgical complications as per Clavien-Dindo, and Kaplan-Meier survival estimates for 24-mo progression-free survival (PFS) and overall survival (OS).Key findings and limitations: In the cohort, 33 (53%) had CS I with a relapse during surveillance, six (10%) CS I with a relapse following adjuvant chemotherapy, and 23 (37%) initial CS IIA/B. Metastatic seminoma was verified in 58 patients (94%) with a median largest diameter of 18 mm (interquartile range [IQR] 13–24). Robot-assisted RPLND was performed in 40 patients (65%). Clavien-Dindo III complications were observed in three patients (5%); no grade ≥IV complications occurred. Eighteen patients (29%) received adjuvant chemotherapy after surgery. The median follow-up was 23 mo (IQR 16–30), and recurrence occurred in six patients (10%) after a median of 8 mo (IQR 4–14). PFS was 90% (95% confidence interval: 0.86–1) and OS was 100% at 24 mo.Conclusions and clinical implications: RPLND as primary treatment is an option for selected low-stage seminomas with a limited burden of disease, showing low complications and low relapse rates, with the potential to reduce long-term morbidity.Patient summary: In seminoma patients with limited metastatic spread, surgery is a treatment option offering an alternative to chemotherapy or radiation. This paper covers the first 62 patients operated in Norway and Sweden.
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| 6. |
- Abbasi, Rasha, et al.
(författare)
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IceCube search for neutrinos from GRB 221009A
- 2023
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Ingår i: Proceedings of 38th International Cosmic Ray Conference - PoS(ICRC 2023). - : Sissa Medialab. ; , s. 1511-
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Konferensbidrag (refereegranskat)abstract
- GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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| 7. |
- Benrick, Anna, 1979, et al.
(författare)
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A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
- 2008
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Ingår i: Regulatory peptides. - : Elsevier BV. - 0167-0115. ; 146:1-3, s. 189-96
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Tidskriftsartikel (refereegranskat)abstract
- Inflammation is a key component in the development of atherosclerosis, and myocardial infarction (MI); therefore we investigated the association between an interleukin-6 signal transducer (IL6ST)/gp130 polymorphism, gp130 function and risk of MI. Structural modeling suggested that a non-conservative single nucleotide polymorphism in the gp130, Gly148Arg, can change the stability and functional properties of the molecule. In vitro studies were done with BAF/3 cells lacking endogenous gp130. Cells stably transfected with the gp130 148Arg variant proliferated less and showed slightly lower STAT-3 phosphorylation in response to gp130 stimulation as compared to cells transfected with gp130 148Gly. In a prospectively followed hypertensive cohort we identified 167 patients who suffered a MI during the study and compared them to matched controls (mean age 57 years, 73% males, n=482). Carriers of the 148Arg variant (f(Arg)=0.12) of the gp130 receptor had decreased odds ratio for MI in univariate analysis (0.56, 95% CI 0.34-0.91, p=0.02). In conclusion, a genetically determined structural variant of the IL-6 receptor subunit gp130 is, independently of other known risk factors, associated with decreased risk of MI. The variant is also associated with decreased IL-6 responsiveness and could lead to a configuration change in the gp130 receptor.
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| 8. |
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| 9. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 10. |
- Carlsson, Anna, et al.
(författare)
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Mothers´ awareness towards child injuries and injury prevention at home : an intervention study
- 2016
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Ingår i: BMC Research Notes. - : BioMed Central. - 1756-0500. ; 18:9, s. 223-228
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Tidskriftsartikel (refereegranskat)abstract
- Flertalet skador som drabbar små barn sker i hemmet. Därför syftade denna studie till att undersöka om utvidgad individuell information till mödrar avseende skador bland barn i hemmet och möjliga preventiva åtgärder har någon effekt på deras medvetenhet kring problemet och om känslan av sammanhang har någon inverkan. Denna studie var designad som en kvasi-experimentell interventionsstudien med en jämförelsegrupp. Utvidgad individuell information med empowerment som förhållningssätt användes. Nittionio mödrar med barn under 7 månader deltog. Ett frågeformulär med sociodemografiska data och frågor angående medvetenhet om prevention användes. Mödrar som deltog i interventionen ökade signifikant sin medvetenhet kring att skador bland barn händer i hemmet jämfört med mödrar i jämförelsegruppen [OR 2.3, CI 1.3-4.3]. Å andra sidan fann studien ingen signifikant förbättring avseende medvetenhet kring prevention, ej heller någon association till mödrarnas känsla av sammanhang. Denna studie visade att interventionen hade en positiv effekt på mödrarnas medvetenhet angående att skador bland barn sker i hemmet, men ökade inte mödrarnas medvetenhet angående att förebygga skador.
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| 11. |
- Carlsson, Anna, et al.
(författare)
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Precautions taken by mothers to prevent burn and scald injuries to young children at home : An intervention study
- 2011
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Ingår i: Scandinavian Journal of Public Health. - : Sage Publications. - 1403-4948 .- 1651-1905. ; 39:5, s. 471-478
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The aim of this study was to investigate to what extent individual-based extended information given to mothers from city parts of low education can improve precautions taken by them to prevent burn and scald injuries involving young children in the home and further to compare the results with a group of mothers who had not received extended information. METHODS: This intervention study, with a comparison group, has a quasi-experimental design. Individual-based information, with an empowerment approach, was given to a group of mothers living in two separate areas of a city in southern Sweden with a low level of education. In total, 99 mothers of children under the age of 7 months participated. The mothers were selected through the local child healthcare authorities. Observations were made and bivariate analyses were established. RESULTS: The results showed that the intervention had a significant impact on improving the precautions the participating mothers introduced to protect their children against burn and scald injuries in the home and further, in relation to a comparison group. CONCLUSIONS: Through empowerment, workshops, and home visits aimed to increase their consciousness and knowledge, the participating mothers' precautions taken against child injuries in the home improved. It is of great importance that a framework for considering the problem of burn and scald injuries to children is presented from a preventive perspective which, in combination with evidence-based interventions, may enable the creation of injury prevention programmes for implementation by the community health care.
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| 12. |
- Connysson, Malin, et al.
(författare)
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Effects of horse housing on musculoskeletal system post-exercise recovery
- 2021
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Ingår i: Comparative Exercise Physiology. - 1755-2540 .- 1755-2559. ; 17, s. 421-428
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Tidskriftsartikel (refereegranskat)abstract
- This study examined the effects of two housing systems (control housing and loose housing) on musculoskeletal condition during recovery from race-like exercise in Standardbred horses. The hypothesis was that a loose housing system provides better conditions for musculoskeletal recovery than the control housing. Eight adult geldings (mean age 11 years) were used in a study with a cross-over design, with the control housing (CH) and loose housing (LH) treatments each run for 21 days. The horses had ad libitum access to forage and performed two similar race-like exercise tests (ET), on day 7 and day 14 in each treatment. Blood samples were collected before ET, at finish line, and at 7, 22, and 44 h of recovery and analysed for the muscle enzyme activities of creatine kinase and amino transferase. Before and three days after ET, hind leg fetlock joint region circumference and diameter, joint range of motion in right hock and carpus, mechanical nociceptive threshold in back muscle, and movement asymmetry were recorded. Overall circumference and overall diameter of hind fetlock joint region were lower in LH horses than CH horses (P=0.045 and P=0.017, respectively), but no other differences were observed. In conclusion, a loose housing system did not alter the recovery of musculoskeletal condition other than preventing a post exercise enlargement of the circumference and diameter of the hind fetlock joint region.
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| 13. |
- Coviello, Andrea D, et al.
(författare)
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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
- 2012
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 8:7
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Tidskriftsartikel (refereegranskat)abstract
- Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p=1.8×10(-106)), PRMT6 (rs17496332, 1p13.3, p=1.4×10(-11)), GCKR (rs780093, 2p23.3, p=2.2×10(-16)), ZBTB10 (rs440837, 8q21.13, p=3.4×10(-09)), JMJD1C (rs7910927, 10q21.3, p=6.1×10(-35)), SLCO1B1 (rs4149056, 12p12.1, p=1.9×10(-08)), NR2F2 (rs8023580, 15q26.2, p=8.3×10(-12)), ZNF652 (rs2411984, 17q21.32, p=3.5×10(-14)), TDGF3 (rs1573036, Xq22.3, p=4.1×10(-14)), LHCGR (rs10454142, 2p16.3, p=1.3×10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p=2.7×10(-08)), and UGT2B15 (rs293428, 4q13.2, p=5.5×10(-06)). These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only (men p=2.5×10(-08), women p=0.66, heterogeneity p=0.003). Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ∼15.6% and ∼8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance.
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| 14. |
- Creignou, Maria, et al.
(författare)
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Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS-M) prediction in myelodysplastic syndromes
- 2024
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Ingår i: Journal of Internal Medicine. - : WILEY. - 0954-6820 .- 1365-2796.
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Tidskriftsartikel (refereegranskat)abstract
- Background The Molecular International Prognostic Scoring System (IPSS-M) is the new gold standard for diagnostic outcome prediction in patients with myelodysplastic syndromes (MDS). This study was designed to assess the additive prognostic impact of dynamic transfusion parameters during early follow-up. Methods We retrieved complete transfusion data from 677 adult Swedish MDS patients included in the IPSS-M cohort. Time-dependent erythrocyte transfusion dependency (E-TD) was added to IPSS-M features and analyzed regarding overall survival and leukemic transformation (acute myeloid leukemia). A multistate Markov model was applied to assess the prognostic value of early changes in transfusion patterns. Results Specific clinical and genetic features were predicted for diagnostic and time-dependent transfusion patterns. Importantly, transfusion state both at diagnosis and within the first year strongly predicts outcomes in both lower (LR) and higher-risk (HR) MDSs. In multivariable analysis, 8-month landmark E-TD predicted shorter survival independently of IPSS-M (p < 0.001). A predictive model based on IPSS-M and 8-month landmark E-TD performed significantly better than a model including only IPSS-M. Similar trends were observed in an independent validation cohort (n = 218). Early transfusion patterns impacted both future transfusion requirements and outcomes in a multistate Markov model. Conclusion The transfusion requirement is a robust and available clinical parameter incorporating the effects of first-line management. In MDS, it provides dynamic risk information independently of diagnostic IPSS-M and, in particular, clinical guidance to LR MDS patients eligible for potentially curative therapeutic intervention.
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| 15. |
- Dawson, Michael N., et al.
(författare)
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A second horizon scan of biogeography: Golden ages, Midas touches, and the Red Queen
- 2016
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Ingår i: Frontiers of Biogeography. - : University of California. - 1948-6596. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- Are we entering a new 'Golden Age' of biogeography, with continued development of infrastructure and ideas? We highlight recent developments, and the challenges and opportunities they bring, in light of the snapshot provided by the 7th biennial meeting of the International Biogeography Society (IBS 2015). We summarize themes in and across 15 symposia using narrative analysis and word clouds, which we complement with recent publication trends and 'research fronts'. We find that biogeography is still strongly defined by core sub-disciplines that reflect its origins in botanical, zoological (particularly bird and mammal), and geographic (e.g., island, montane) studies of the 1800s. That core is being enriched by large datasets (e.g. of environmental variables, 'omics', species' occurrences, traits) and new techniques (e.g., advances in genetics, remote sensing, modeling) that promote studies with increasing detail and at increasing scales; disciplinary breadth is being diversified (e.g., by developments in paleobiogeography and microbiology) and integrated through the transfer of approaches and sharing of theory (e.g., spatial modeling and phylogenetics in evolutionary-ecological contexts). Yet some subdisciplines remain on the fringe (e.g., marine biogeography, deep-time paleobiogeography), new horizons and new theory may be overshadowed by popular techniques (e.g., species distribution modelling), and hypotheses, data, and analyses may each be wanting. Trends in publication suggest a shift away from traditional biogeography journals to multidisciplinary or open access journals. Thus, there are currently many opportunities and challenges as biogeography increasingly addresses human impacts on, and stewardship of, the planet (e.g., Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services). As in the past, biogeographers doubtless will continue to be engaged by new data and methods in exploring the nexus between biology and geography for decades into the future. But golden ages come and go, and they need not touch every domain in a discipline nor affect subdisciplines at the same time; moreover, what appears to be a Golden Age may sometimes have an undesirable 'Midas touch'. Contexts within and outwith biogeography-e.g., methods, knowledge, climate, biodiversity, politics-are continually changing, and at times it can be challenging to establish or maintain relevance. In so many races with the Red Queen, we suggest that biogeography will enjoy greatest success if we also increasingly engage with the epistemology of our discipline.
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| 16. |
- Dreja, Karl, et al.
(författare)
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Njursjukdomar
- 2016
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Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 457-482
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Bokkapitel (populärvet., debatt m.m.)
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| 17. |
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| 18. |
- Drevenhorn, Eva, et al.
(författare)
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Risk för ohälsa
- 2016
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Ingår i: Omvårdnad och medicin. - : Studentlitteratur AB. - 9789144076645 ; , s. 73-92
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
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| 19. |
- Eriksson, Kaja, et al.
(författare)
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Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
- 2019
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:5
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.
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| 20. |
- Gagnemo Persson, Rebecca, et al.
(författare)
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Lungsjukdomar
- 2016. - 1
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Ingår i: Omvårdnad och medicin. - 9789144076645 ; , s. 281-311
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Bokkapitel (populärvet., debatt m.m.)
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| 21. |
- Gagnemo Persson, Rebecca, et al.
(författare)
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Läkemedel
- 2016. - 1
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Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 125-138
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Bokkapitel (populärvet., debatt m.m.)
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| 22. |
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| 23. |
- Garrido, Pablo, et al.
(författare)
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Experimental rewilding enhances grassland functional composition and pollinator habitat use
- 2019
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Ingår i: Journal of Applied Ecology. - : Wiley. - 0021-8901 .- 1365-2664. ; 56, s. 946-955
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Tidskriftsartikel (refereegranskat)abstract
- Semi-natural grasslands are rich in biodiversity and thus important habitats for conservation, yet they are experiencing rapid declines due to agricultural intensification and abandonment. Promoting a more diverse mammalian herbivore community, including large and megaherbivores, may result in positive cascade effects for biodiversity and ecosystem functioning. Therefore, reintroducing an ecologically functional substitute of an extinct large herbivore could mitigate current biodiversity declines and foster semi-natural grassland conservation. To test this hypothesis, we set up a 3-year rewilding experiment where 12 feral horses were introduced in three 10-hectare enclosure replicates (four horses per enclosure). We used community-weighted mean plant functional traits to elucidate plant community changes induced by grazing through time. We also investigated the effects of this experimental treatment on insect pollinated plants and on pollinator habitat use. The grassland community exerted a mixed tolerance/avoidance response to grazing. This resulted in plant functional compositional changes which favoured prostrate plant species with higher specific leaf area, characteristic of ruderal communities. Plant species richness was higher in grazed compared to ungrazed areas. Butterfly and bumblebee habitat use, as well as feeding and resting activities were also higher in grazed areas. Moreover, the number of pollinators increased with plant species richness.Synthesis and applications. This study demonstrates that, to enhance the diversity of a given herbivore community with ecological replacements of extinct wild horses can have significant effects on the functional composition of grasslands. It can also mitigate plant species declines, in particular bee-dependent plants, and boost pollinator habitat use. Novel management alternatives are urgently needed to reverse the negative effect of land abandonment in European agricultural landscapes. Thus, rewilding interventions with large mammalian herbivores may offset current biodiversity declines by maintaining important functional links between plants and pollinators in grassland ecosystems.Foreign Language AbstractSammanfattningNaturbetesmarker ar rika pa biologisk mangfald och ar darmed av stor betydelse for naturvarden. Tyvarr minskar arealen av dessa marker pa grund av intensifieringar inom jordbruket och andrad djurhallning. En variationsrik djurhallning med stora daggdjur kan resultera i positiva foljdeffekter for biologisk mangfald och mer funktionella ekosystem. Genom att aterinfora ekologiskt funktionella ersattare for utdoda stora vaxtatare kan vi pa sa vis minska forlusten av biologisk mangfald och gynna bevarandet av naturbetesmarker. For att testa detta genomfordes ett trearigt faunarestaurerings-forsok med 12 hastar som fick beta i tre stycken 10-hektar stora hagn (fyra hastar i varje). Vi anvande medelvarden av vaxtsamhallets funktionella egenskaper for att studera hur hastarnas bete forandrade vaxtsamhallet over tid. Vi studerade aven effekter pa insektpollinerade vaxter och hur pollinerande insekter nyttjade forsoksytorna. Vaxterna uppvisade en blandning av tolerans och undvikande som respons mot betandet, vilket resulterade i funktionella forandringar som gynnade lagvaxande arter med stora blad, sa kallade ruderatvaxter. Vaxtrikedomen var hogre pa betade ytor an pa obetade. Det var aven storre forekomst av fodosokande och vilande fjarilar och humlor pa betade ytor. Antalet pollinerande insekter okade med vaxtrikedomen.Syntes och tillampning. Var studie visar att vi genom en vildare djurhallning kan aterskapa hastens ekosystemfunktion och att det ger positiva effekter pa vaxtsamhallets funktionella sammansattning. En vildare djurhallning kan aven motverka forlusten pollinerade vaxter och oka mangden pollinerande insekter. Nya forvaltningsmetoder behovs for att vanda den genomgripande utvecklingen kopplat till igenvaxning av det europeiska jordbrukslandskapet. angstrom terforandet av stora vaxtatande daggdjur kan forhindra forlusten av biologisk mangfald och uppratthalla viktiga funktionella kopplingar mellan vaxter och dess pollinatorer i naturbetesmarker.This study demonstrates that, to enhance the diversity of a given herbivore community with ecological replacements of extinct wild horses can have significant effects on the functional composition of grasslands. It can also mitigate plant species declines, in particular bee-dependent plants, and boost pollinator habitat use. Novel management alternatives are urgently needed to reverse the negative effect of land abandonment in European agricultural landscapes. Thus, rewilding interventions with large mammalian herbivores may offset current biodiversity declines by maintaining important functional links between plants and pollinators in grassland ecosystems.
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| 24. |
- Garrido, Pablo, et al.
(författare)
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Experimental rewilding may restore abandoned wood-pastures if policy allows
- 2021
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Ingår i: AMBIO: A Journal of the Human Environment. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 20, s. 101-112
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Tidskriftsartikel (refereegranskat)abstract
- Large herbivores play key roles in terrestrial ecosystems. Continuous defaunation processes have produced cascade effects on plant community composition, vegetation structure, and even climate. Wood-pastures were created by traditional management practices that have maintained open structures and biodiversity for millennia. In Europe, despite the broad recognition of their biological importance, such landscapes are declining due to land-use changes. This calls for finding urgent solutions for wood-pasture conservation. To test whether introducing an ecological replacement of an extinct wild horse could have positive effects on wood-pasture restoration, we designed a 3-year rewilding experiment. Horses created a more open wood-pasture structure by browsing on seedlings and saplings, affected tree composition via selective browsing and controlled the colonization of woody vegetation in grassland-dominated areas. Thus, rewilding could be a potential avenue for wood-pasture restoration and biodiversity conservation. However, such benefits may not materialize without a necessary paradigm and political shift.
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| 25. |
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| 26. |
- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 27. |
- Jansson, Anna, 1979-, et al.
(författare)
-
DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
- 2013
-
Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 56:15, s. 6190-6199
-
Tidskriftsartikel (refereegranskat)abstract
- The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway producing the universally essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs from the classical mevalonate pathway that is essential in humans. Using a structure-based approach, we designed a number of analogues of fosmidomycin, including a series that are substituted in both the Cα and the hydroxamate positions. The latter proved to be a stable framework for the design of inhibitors that extend from the cramped substrate-binding site and can, for the first time, bridge the substrate and cofactor binding sites. A number of these compounds are more potent than fosmidomycin in terms of killing Plasmodium falciparum in an in vitro assay; the best has an IC50 of 40 nM.
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| 28. |
- Jansson, Anna. K., et al.
(författare)
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Risk and mortality of testicular cancer in patients with neurodevelopmental or other psychiatric disorders
- 2023
-
Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 128:12, s. 2261-2269
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundBoth testicular germ cell tumours (TGCT) and neurodevelopmental disorders are associated with urogenital malformations. Few studies have investigated the association between psychiatric disorders and TGCT. We investigated whether history of any psychiatric or neurodevelopmental disorder is associated with increased risk or mortality of TGCT.MethodThis is a nested case-control study including 6166 TGCT patients diagnosed during 1992-2014, individually matched for age and calendar period to 61,660 controls. We calculated odds ratios (ORs) for the association between type of psychiatric diagnoses and TGCT risk. Among the cases, we used a cohort design and calculated hazard ratios (HRs) of the association between psychiatric diagnose and all-cause and TGCT-specific death.ResultsHistory of a neurodevelopmental disorder (attention deficit hyperactivity disorder, autism spectrum disorder and intellectual disabilities) was associated with an increased risk of seminoma (OR: 1.54; 1.09-2.19). Seminoma patients with neurodevelopmental disorders were younger (34 versus 38 years, p = 0.004) and had more stage IV disease (5.4% versus 1.2%) than those without. Psychiatric history overall was not associated with TGCT. Patient history of any psychiatric disorder was associated with an increased all-cause and TGCT-specific death.ConclusionsWe report an association between neurodevelopmental disorders and testicular seminoma, and an increased TGCT-specific mortality for TGCT patients with psychiatric disorders.
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| 29. |
- Jansson, Anna, et al.
(författare)
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Magnetron sputtering of the high entropy alloy CoCrFeMnNi on 316L : Influence of substrate grain orientations
- 2023
-
Ingår i: Surface & Coatings Technology. - : Elsevier. - 0257-8972 .- 1879-3347. ; 466
-
Tidskriftsartikel (refereegranskat)abstract
- This study explores the influence of a 316L stainless steel substrate on the magnetron sputtering of the Cantor alloy CoCrFeMnNi at different substrate bias. The study was carried out on a polycrystalline 316L substrate where the growth behavior of the coating could be investigated on grains with different orientations. By combining electron backscatter diffraction (EBSD) before and after deposition and characterization of the same area, it was possible to determine growth behaviour and surface morphologies on individual substrate grains. No strong influence of the substrate was observed at a floating bias. At a bias of -100V, however, the coating was strongly influenced by the orientation of the individual substrate grains. Epitaxial coating grains with a smooth surface were observed on the [102]-oriented grains while a more columnar growth was observed on [111]-oriented grains. Furthermore, a small difference in growth rate was observed on different substrate orientations. The growth behaviour could be related to differences in surface energies and diffusion rates on different surface orientations.
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| 30. |
- Jansson, Anna, et al.
(författare)
-
Shaping the Swedish landscape: a future for the Gotland russ
- 2016
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Tree encroachment and abandonment of pastures is an important cause of biodiversity loss in Sweden. In thisstudy, we evaluate the impact of all-year-around grazing by an ancient horse breed, the Gotland russ (GR),on tree encroachment. Twelve GR stallions were kept in 3 enclosures (lat: 59, long: 17, 4 GR/enclosure, 7ha forest and 3 ha open fields/enclosure) from May 2014 (age 1 yrs) until February 2016. Prior to the study,3 exclosures (EX, 5×42.5 m) where GR grazing was excluded were centered with the long side at the borderbetween forest and field. The field part of EX were further divided into four 5×5 m sections starting from theforest (1 to 4). Tree type (deciduous, spruce or pine), number and height were registered in the sections and theequivalent, grazed area adjacent to the EX on the 25th of February 2016. Body condition (BC) was assessedweekly using a 9 leveled scoring system. Individuals <4 were withdrawn, fed and reintroduced when BC was>4. Analysis of tree heights and numbers were made by procGLM in SAS. There was no difference in the totalnumber of deciduous trees (21±8 vs 25±8), spruces (2±1 vs 3±1) and pines (0.2±0.2 vs 0.8±0.2) between EXand grazed areas (P>0.05). In the grazed areas, the deciduous trees were shorter compared to the trees in EX(330±57 vs 780±70 mm, P<0.0001). There was no difference in spruce height (EX: 920±110 vs grazed areas:780±130 mm, P=0.31). In the grazed areas, tree height decreased from quarter 1 to 4 (1: 610±60, 2: 230±110, 3:140±90 and 4: 60±100 mm, P<0.0001) whereas in EX, the height increased (1: 740±60, 2: 570±150, 3: 810±90and 4: 960±100 mm, P<0.02). Four individuals (3 from the same enclosure) were withdrawn temporarily inFebruary 2015 due to BC <4. The study show that grazing by GR may inhibit encroachment by deciduoustrees and that BC was maintained in most individuals, despite the semi-feral conditions. The results providea new use for a threatened, ancient breed in landscape management.
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| 31. |
- Jansson, Andreas, et al.
(författare)
-
The role of mass media in corporate governance : a study of how Swedish corporations are affected by the character of publicity
- 2016
-
Konferensbidrag (refereegranskat)abstract
- Large corporations are the objects of large amounts of media attention. Despite this, the literature pertaining to the role the media may play in shaping corporate governance structures and processes is at a fairly rudimentary state (Bednar, 2012). The media has, nevertheless, variously been portrayed as an ally to shareholders that monitors and reports corporate misbehavior (e.g., Dyck & Zingales, 2008); as an agenda setter that shapes priorities in corporate decision making and corporate reputations (e.g., Carrol & McCombs, 2003); as a propagator of legitimacy defining acceptable corporate behavior (Bednar, 2012; Jansson, 2013); and as an arena for collective meaning making of corporate events (Jansson, in press). While the literature converges on the idea that the media by ‘naming and shaming’ certain practices can delegitimate corporations and thereby change corporate behavior, issues such as whether variation in types of publicity creates varying outcomes and how institutional differences affect the impact of the media on large corporations, remains largely unresolved.In this paper we report a study of how various types of publicity in the press affects corporate governance in large Swedish listed firms. Building on previously published instruments, we develop and validate an instrument for capturing the intensity of both positive and negative publicity using quantitative content analysis that we apply to Swedish print media pertaining both to the firm and its CEO specifically over the period 1999-2013. We analyze the impact of this publicity on corporate governance in terms of CEO resignation and CEO pay level as well as distribution.Interestingly, our tentative results suggest that neither positive nor negative publicity on the CEO or the corporation affects either CEO resignation or CEO pay level and distribution. Thus, our results do not conform to previous research having established the importance of media as a gate-keeper. Whereas Bednar (2012) questions the role of media as watchdog in that largely symbolic actions may have important corporate effects, we instead find that media reports have no effect at all. A possible explanation for this may be that the information reported in media is already well-known to the business society, therefore having no effect when published. This is perhaps not very surprising given how close-knit Swedish business relations are (Sinani et al., 2008) and indeed how close the relations between Swedish corporations and the business press tend to be (Grünberg & Pallas, 2013).Our paper contributes to the literature on the role of media in corporate governance in illustrating how patterns of response to media attention among Swedish firms differ from that of U.S. firms, suggesting that while the media may function as propagators of legitimacy, the underlying normative model propagated may differ among national contexts, implying that the media will have different outcomes in different parts of the world (cf. Jansson, 2013) and indeed sometimes no results at all.
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| 32. |
- Jansson, Birgitta, 1959-
(författare)
-
Varför har dom ingen tvättmaskin? : Critical literacy hos elever årskurs 2 och 3
- 2022
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Vilka möjligheter finns för unga elever i skolår 2 och 3 att utveckla ett critical literacy-perspektiv utifrån den undervisning de deltar i och de texter de möter? Texter är inte bara skriven text utan text kan vara en bild, en film, ett inlägg på Instagram eller ett musikstycke som ska tolkas. Förståelsen av begreppet läskunnighet behöver därför vidgas eftersom eleven, förutom att läsa och skriva skriven text, också måste kunna tolka, reflektera över, kritiskt granska och skapa mening ur olika typer av källor. En sådan undervisning bidrar också till elevers utveckling till demokratiska medborgare, vilket också är ett övergripande mål i skolans styrdokument.I föreliggande licentiatuppsats undersöks möjligheterna för unga elever i skolår 2 och 3 att utveckla ett critical literacy-perspektiv utifrån den undervisning de deltar i. Syftet är att belysa om och i så fall hur undervisning i årskurs 2 och 3 skapar förutsättningar för elever att utveckla critical literacy. De kunskaperna behövs även för att kunna agera aktivt som samhällsmedborgare. Att kunna läsa och förstå texter ur olika perspektiv, att förstå att texter kan utesluta eller skapa fördelar för olika individer och att texter positionerar läsaren är en del av vad critical literacy handlar om. En teoretisk utgångspunkt för denna studie är därmed att elever, genom att läsa och arbeta med texter ur ett critical literacy-perspektiv, ges verktyg att bearbeta och tolka olika texter och skapa en förståelse för hur olika texter påverkar människor. Studien fokuserar på elevers respons i undervisning och datamaterial har samlats in i en klass med 20 elever under deras tid i klass 2 och 3 och består av klassrumsobservationer och intervjuer. Vid analys av materialet har Janks (2010) fyra begrepp, domination, access, diversity och design, använts för att analysera elevernas respons relaterat till olika textaktiviteter. Resultatet visar att elever, utan någon speciell undervisning om critical literacy, i sina diskussioner, framför allt i samhälls- och naturvetenskapliga ämnen, uppmärksammar vilka som dominerar i texter och varför vissa människor framstår som viktigare än andra. En slutsats är att unga elever både kan och vill diskutera svåra frågor om förutsättningar ges. När undervisningen har ett critical literacyperspektiv ges eleverna möjlighet att upptäcka och möjligen också bättre förstå sin omvärld. Genom sina egna erfarenheter kan eleverna inte bara visa medvetenhet om människor olika villkor utan också bidra med alternativ till förändring.
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| 33. |
- Jansson, Nina, 1976, et al.
(författare)
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Maternal hormones linking maternal body mass index and dietary intake to birth weight.
- 2008
-
Ingår i: American Journal of Clinical Nutrition. - Bethesda, USA : American Society for Nutrition. - 0002-9165 .- 1938-3207. ; 87:6, s. 1743-9
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Obese women often give birth to large-for-gestational age infants (typically defined as a birth weight greater than the 90th percentile), who are at risk of birth injuries and of developing metabolic syndrome later in life. The mechanisms underlying increased fetal growth remain to be established. OBJECTIVE: We aimed to identify maternal hormones that can explain the link between dietary intake, body mass index (BMI), and birth weight. DESIGN: Pregnant women with BMIs (in kg/m(2)) ranging from 17 to 44 (n = 49) were recruited in gestational weeks 8-12. Serum hormone concentrations were measured and dietary history interviews were performed in the first and third trimesters. Multiple regression models were produced to identify hormones that correlate with birth weight and are influenced by BMI or dietary factors. RESULTS: We found a strong positive correlation between BMI and first- and third-trimester insulin and leptin concentrations and a negative correlation between BMI and first-trimester adiponectin and first- and third-trimester insulin-like growth factor binding protein-1 (IGFBP-1). Maternal total fat intake in the first trimester was positively correlated with maternal leptin and inversely correlated with adiponectin. In addition, third-trimester total fat intake was positively correlated with circulating resistin concentrations. First-trimester maternal serum resistin was positively correlated with birth weight, whereas third-trimester maternal IGFBP-1 was negatively correlated with birth weight. CONCLUSIONS: High first-trimester maternal serum resistin and low third-trimester IGFBP-1 were correlated with increased birth weight. We propose that low serum concentrations of IGFBP-1 represent a link between high BMI and increased fetal growth by increasing the bioavailability of insulin-like growth factor-I, which up-regulates placental nutrient transport.
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| 34. |
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| 35. |
- Jönsson, Ann-Cathrin, et al.
(författare)
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Neurologiska sjukdomar
- 2016. - 1
-
Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 155-190
-
Bokkapitel (populärvet., debatt m.m.)
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| 36. |
- Jönsson, Ann-Cathrin, et al.
(författare)
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Stroke
- 2016
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Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 191-214
-
Bokkapitel (populärvet., debatt m.m.)
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| 37. |
- Klintman, Jenny, et al.
(författare)
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Blodsjukdomar
- 2016. - 1
-
Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 587-621
-
Bokkapitel (populärvet., debatt m.m.)
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| 38. |
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| 39. |
- Li, Meng, et al.
(författare)
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Bark beetles as lidar targets and prospects of photonic surveillance
- 2021
-
Ingår i: Journal of Biophotonics. - : Wiley. - 1864-063X .- 1864-0648. ; 14:4
-
Tidskriftsartikel (refereegranskat)abstract
- Forestry is raising concern about the outbreaks of European spruce bark beetle, Ips typographus, causing extensive damage to the spruce forest and timber values. Precise monitoring of these beetles is a necessary step towards preventing outbreaks. Current commercial monitoring methods are catch‐based and lack in both temporal and spatial resolution. In this work, light scattering from beetles is characterized, and the feasibility of entomological lidar as a tool for long‐term monitoring of bark beetles is explored. Laboratory optical properties, wing thickness, and wingbeat frequency of bark beetles are reported, and these parameters can infer target identity in lidar data. Lidar results from a Swedish forest with controlled bark beetle release event are presented. The capability of lidar to simultaneously monitor both insects and a pheromone plume mixed with chemical smoke governing the dispersal of many insects is demonstrated. In conclusion, entomological lidar is a promising tool for monitoring bark beetles.
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| 40. |
- Lundmark, Anna, et al.
(författare)
-
Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis
- 2017
-
Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 44:3, s. 247-254
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: Periodontitis is a chronic inflammatory disease, characterized by irreversible destruction of tooth-supporting tissue including alveolar bone. We recently reported mucin 4 ( MUC4) and matrix metalloproteinase 7 (MMP7) as highly associated with periodontitis in gingival tissue biopsies. The aim of this study was to further investigate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of patients with periodontitis. Materials and Methods: Saliva and GCF samples were collected from periodontitis patients and healthy controls. The levels of MUC4, MMP7, and total protein concentrations were analysed using ELISA or Bradford assay. Results: MUC4 levels were significantly lower in saliva and GCF from periodontitis patients relative to healthy controls. MMP7 levels were significantly higher in saliva and GCF from periodontitis patients. Multivariate analysis revealed that MUC4 was significantly associated with periodontitis after adjusting for age and smoking habits and, moreover, that the combination of MUC4 and MMP7 accurately discriminated periodontitis from healthy controls. Conclusions: MUC4 and MMP7 may be utilized as possible novel biomarkers for periodontitis.
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| 41. |
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| 42. |
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| 43. |
- Mareschal, Sylvain, et al.
(författare)
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Challenging conventional karyotyping by next-generation karyotyping in 281 intensively treated patients with AML
- 2021
-
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 5:4, s. 1003-1016
-
Tidskriftsartikel (refereegranskat)abstract
- Although copy number alterations (CNAs) and translocations constitute the backbone of the diagnosis and prognostication of acute myeloid leukemia (AML), techniques used for their assessment in routine diagnostics have not been reconsidered for decades. We used a combination of 2 next-generation sequencing-based techniques to challenge the currently recommended conventional cytogenetic analysis (CCA), comparing the approaches in a series of 281 intensively treated patients with AML. Shallow whole-genome sequencing (sWGS) outperformed CCA in detecting European Leukemia Net (ELN)-defining CNAs and showed that CCA overestimated monosomies and suboptimally reported karyotype complexity. Still, the concordance between CCA and sWGS for all ELN CNA-related criteria was 94%. Moreover, using in silico dilution, we showed that 1 million reads per patient would be enough to accurately assess ELN-defining CNAs. Total genomic loss, defined as a total loss 200 Mb by sWGS, was found to be a better marker for genetic complexity and poor prognosis compared with the CCA-based definition of complex karyotype. For fusion detection, the concordance between CCA and whole-transcriptome sequencing (WTS) was 99%. WTS had better sensitivity in identifying inv(16) and KMT2A rearrangements while showing limitations in detecting lowly expressed PML-RARA fusions. Ligation-dependent reverse transcription polymerase chain reaction was used for validation and was shown to be a fast and reliable method for fusion detection. We conclude that a next-generation sequencing-based approach can replace conventional CCA for karyotyping, provided that efforts are made to cover lowly expressed fusion transcripts.
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| 44. |
- Meysick, Lukas, et al.
(författare)
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Context-dependent community facilitation in seagrass meadows along a hydrodynamic stress gradient
- 2019
-
Ingår i: Journal of Sea Research. - : Elsevier BV. - 1385-1101 .- 1873-1414. ; 150, s. 8-23
-
Tidskriftsartikel (refereegranskat)abstract
- Foundation species host diverse associated communities by ameliorating environmental stress. The strength of this facilitative effect can be highly dependent on the underlying biotic and abiotic context. We investigated community level patterns of macrofauna associated with and adjacent to the marine foundation species eelgrass (Zostera marina) along a hydrodynamic stress gradient. We could demonstrate that the relative importance of this foundation species for its infaunal community increases with environmental variables associated with increasing hydrodynamic stress (depth, sand ripples formation, sediment grain size and organic content). Faunal assemblages in proximity to the Zostera patch edges, however, showed no (infauna) or negative (epifauna) response to hydrodynamic stress. Our study highlights that the facilitative outcome of a foundation species is conditional to the faunal assemblage in question and can be highly variable even between positions within the habitat.
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| 45. |
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| 46. |
- Nyesiga, Barnabas, et al.
(författare)
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RUBY® - a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
- 2024
-
Ingår i: mAbs. - : Taylor & Francis. - 1942-0862 .- 1942-0870. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows rapid generation of bsAbs that fulfill key development criteria. The RUBYTM format has a 2 + 2 geometry, where two Fab fragments are linked via their light chains to the C-termini of an IgG, and carries mutations for optimal chain pairing. The unique design enables generation of bsAbs with mAb-like attributes. Our data demonstrate that RUBY bsAbs are compatible with small-scale production systems for screening purposes and can be produced at high yields (>3 g/L) from stable cell lines. The bsAbs produced are shown to, in general, contain low amounts of aggregates and display favorable solubility and stress endurance profiles. Further, compatibility with various IgG isotypes is shown and tailored Fc gamma receptor binding confirmed. Also, retained interaction with FcRn is demonstrated to translate into a pharmacokinetic profile in mice and non-human primates that is comparable to mAb controls. Functionality of conditional active RUBY bsAbs is confirmed in vitro. Anti-tumor effects in vivo have previously been demonstrated, and shown to be superior to a comparable mAb, and here it is further shown that RUBY bsAbs penetrate and localize to tumor tissue in vivo. In all, the RUBY format has attractive mAb-like attributes and offers the possibility to mitigate many of the development challenges linked to other bsAb formats, facilitating both high functionality and developability.
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| 47. |
- Ohlsson, Claes, 1965, et al.
(författare)
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Genetic determinants of serum testosterone concentrations in men.
- 2011
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 7:10
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Tidskriftsartikel (refereegranskat)abstract
- Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n=871) and two de novo replication cohorts (n=4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as <300 ng/dl. Two single-nucleotide polymorphisms at the sex hormone-binding globulin (SHBG) locus (17p13-p12) were identified as independently associated with serum testosterone concentration (rs12150660, p=1.2×10(-41) and rs6258, p=2.3×10(-22)). Subjects with ≥ 3 risk alleles of these variants had 6.5-fold higher risk of having low serum testosterone than subjects with no risk allele. The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p=5.6×10(-16)). The rs6258 polymorphism in exon 4 of SHBG affected SHBG's affinity for binding testosterone and the measured free testosterone fraction (p<0.01). Genetic variants in the SHBG locus and on the X chromosome are associated with a substantial variation in testosterone concentrations and increased risk of low testosterone. rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation.
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| 48. |
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| 49. |
- Rajiullah, Mohammad, et al.
(författare)
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Enhancing Healthcare Remote Education with 6G and XR Technologies
- 2024
-
Ingår i: The 3rd edition of the International Conference on 6G Networking (6GNet 2024), Paris, October 2024.. - New York : IEEE Communications Society.
-
Konferensbidrag (refereegranskat)abstract
- As the adoption of Fifth Generation (5G) systems increases, efforts towards Sixth Generation (6G) systems have already started across research, standardization, and stakeholder fora. 6G is expected to support applications with immersive capabilities, with specific use case requirements from different verticals playing a critical role in solution development. Unlike current solutions in the education vertical that uses immersive technologies such as Augmented/Virtual/eXtended Reality (AR/VR/XR), which rely on pre-recorded content and lack engagement, 6G can enhance remote education by enabling real-time, AR/VR/XR-enriched interactions among students and instructors. This paper presents ongoing activities within the 6G-PATH EU project, towards the design, implementation, and testing of a 6G use case for healthcare personnel remote education/training, which aims to facilitate real-time, AR/VR/XR-enhanced interactions among healthcare trainees and instructors.
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| 50. |
- Skarin, Anna, et al.
(författare)
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Impact of Year-Round Grazing by Horses on Pasture Nutrient Dynamics and the Correlation with Pasture Nutrient Content and Fecal Nutrient Composition
- 2019
-
Ingår i: Animals. - : MDPI AG. - 2076-2615. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Simple Summary Horse grazing may benefit biodiversity. This study compared the effect of horses grazing year-round to that of mowing on pasture quality in a forest-grassland landscape in Sweden. Twelve Gotlandsruss stallions were kept in three enclosures (similar to 0.35 horse/hectare) without supplementary feeding for 2.5 years. Each enclosure contained three exclosures where pasture was not grazed, but mown monthly. Horse grazing increased the diversity of pasture nutrient content. Moreover, energy and protein concentrations and grass availability increased in areas grazed by horses, but decreased where grass was mown. This indicates that year-round grazing can be used to increase biodiversity, a suggestion supported by botanical observations. Nutrient content in horses' droppings was found to correlate with nutrient content in pasture, so analysis of droppings may be used to roughly estimate the quality of pasture consumed by horses. Under the conditions studied, pasture protein content was sufficient to meet horse requirements year-round, while energy content and pasture availability may have been limited in winter. Monthly data presented here on the nutritive value of pasture can help guide the management of year-round grazing systems in the Nordic countries. Horse grazing may benefit biodiversity, but the impact of year-round grazing on nutrient dynamics has not been evaluated previously. This study compared pasture quality in a forest-grassland landscape grazed year-round by horses with that in exclosed mown areas. Twelve Gotlandsruss stallions were kept without supplementary feeding in three enclosures (similar to 0.35 horse/ha) outside Uppsala, Sweden, from May 2014 to September 2016. Each enclosure contained three mown exclosures, where grass sward samples were collected monthly and analyzed for chemical composition and vegetation density. Fecal grab samples were collected and analyzed for crude protein (CP) and organic matter (OM) content. There were no differences in exclosure pasture energy or CP content between enclosures (p > 0.05). In grazed areas, there were differences in grass energy and CP content (p > 0.05) between enclosures. During the three summers studied, energy and CP content increased in the enclosures, but decreased in the exclosures. By the end, biomass content/ha was greater in the enclosures than in the exclosures. Fecal OM and CP content showed moderate to strong correlations with pasture nutrient content (r = 0.3-0.8, p < 0.05). Thus, in contrast to monthly mowing, horse grazing diversified pasture chemical composition and increased its nutritive value.
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