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Träfflista för sökning "WFRF:(Jarvinen Heikki) "

Search: WFRF:(Jarvinen Heikki)

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  • Lappalainen, Hanna K., et al. (author)
  • Pan-Eurasian Experiment (PEEX) : towards a holistic understanding of the feedbacks and interactions in the land-atmosphere-ocean-society continuum in the northern Eurasian region
  • 2016
  • In: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 16:22, s. 14421-14461
  • Journal article (peer-reviewed)abstract
    • The northern Eurasian regions and Arctic Ocean will very likely undergo substantial changes during the next decades. The Arctic-boreal natural environments play a crucial role in the global climate via albedo change, carbon sources and sinks as well as atmospheric aerosol production from biogenic volatile organic compounds. Furthermore, it is expected that global trade activities, demographic movement, and use of natural resources will be increasing in the Arctic regions. There is a need for a novel research approach, which not only identifies and tackles the relevant multi-disciplinary research questions, but also is able to make a holistic system analysis of the expected feedbacks. In this paper, we introduce the research agenda of the Pan-Eurasian Experiment (PEEX), a multi-scale, multi-disciplinary and international program started in 2012 (https://www.atm.helsinki.fi/peex/). PEEX sets a research approach by which large-scale research topics are investigated from a system perspective and which aims to fill the key gaps in our understanding of the feedbacks and interactions between the land-atmosphereaquatic-society continuum in the northern Eurasian region. We introduce here the state of the art for the key topics in the PEEX research agenda and present the future prospects of the research, which we see relevant in this context.
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2.
  • Wang, Chuan, et al. (author)
  • Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
  • 2013
  • In: European Journal of Human Genetics. - : Nature Publishing Group: Open Access Hybrid Model Option B. - 1018-4813 .- 1476-5438. ; 21:9, s. 994-999
  • Journal article (peer-reviewed)abstract
    • Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case–control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.
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journal article (2)
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peer-reviewed (2)
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Shvidenko, Anatoly (1)
Bengtsson, Anders (1)
Gunnarsson, Iva (1)
Svenungsson, Elisabe ... (1)
Jönsen, Andreas (1)
Truedsson, Lennart (1)
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Sturfelt, Gunnar (1)
Eloranta, Maija-Leen ... (1)
Nordmark, Gunnel (1)
Kere, Juha (1)
Hansson, Hans-Christ ... (1)
Rönnblom, Lars (1)
Wang, Chuan (1)
Syvänen, Ann-Christi ... (1)
Criswell, Lindsey A. (1)
Eriksson, Catharina (1)
Ahlford, Annika (1)
Padyukov, Leonid (1)
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Kurten, Theo (1)
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Viisanen, Yrjo (1)
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Kerminen, Veli-Matti (1)
de Leeuw, Gerrit (1)
Mikhailov, Eugene (1)
Kukkonen, Ilmo (1)
Juhola, Sirkku (1)
Lihavainen, Heikki (1)
Sun, Junying (1)
Asmi, Eija (1)
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Tynkkynen, Veli-Pekk ... (1)
Duplissy, Ella-Maria (1)
Behrens, Timothy W (1)
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Konstantinov, Pavel (1)
Sjöwall, Christoffer (1)
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