| 1. |
- Davison, Lucy J, et al.
(författare)
-
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene
- 2012
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:2, s. 322-333
-
Tidskriftsartikel (refereegranskat)abstract
- The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A, containing the most autoimmune disease-associated SNPs, appears to behave as a regulatory sequence, affecting the expression of a neighbouring gene, DEXI. The CLEC16A alleles that are protective from T1D and MS are associated with increased expression of DEXI, and no other genes in the region, in two independent monocyte gene expression data sets. Critically, using chromosome conformation capture (3C), we identified physical proximity between the DEXI promoter region and intron 19 of CLEC16A, separated by a loop of >150 kb. In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A. Intron 19 of CLEC16A is highly enriched for transcription-factor-binding events and markers associated with enhancer activity. Taken together, these data indicate that although the causal variants in the 16p13 region lie within CLEC16A, DEXI is an unappreciated autoimmune disease candidate gene, and illustrate the power of the 3C approach in progressing from genome-wide association studies results to candidate causal genes.
|
|
| 2. |
|
|
| 3. |
- Huaraca Huasco, Walter, et al.
(författare)
-
Fine root dynamics across pantropical rainforest ecosystems
- 2021
-
Ingår i: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 27:15, s. 3657-3680
-
Tidskriftsartikel (refereegranskat)abstract
- Fine roots constitute a significant component of the net primary productivity (NPP) of forest ecosystems but are much less studied than aboveground NPP. Comparisons across sites and regions are also hampered by inconsistent methodologies, especially in tropical areas. Here, we present a novel dataset of fine root biomass, productivity, residence time, and allocation in tropical old-growth rainforest sites worldwide, measured using consistent methods, and examine how these variables are related to consistently determined soil and climatic characteristics. Our pantropical dataset spans intensive monitoring plots in lowland (wet, semi-deciduous, and deciduous) and montane tropical forests in South America, Africa, and Southeast Asia (n = 47). Large spatial variation in fine root dynamics was observed across montane and lowland forest types. In lowland forests, we found a strong positive linear relationship between fine root productivity and sand content, this relationship was even stronger when we considered the fractional allocation of total NPP to fine roots, demonstrating that understanding allocation adds explanatory power to understanding fine root productivity and total NPP. Fine root residence time was a function of multiple factors: soil sand content, soil pH, and maximum water deficit, with longest residence times in acidic, sandy, and water-stressed soils. In tropical montane forests, on the other hand, a different set of relationships prevailed, highlighting the very different nature of montane and lowland forest biomes. Root productivity was a strong positive linear function of mean annual temperature, root residence time was a strong positive function of soil nitrogen content in montane forests, and lastly decreasing soil P content increased allocation of productivity to fine roots. In contrast to the lowlands, environmental conditions were a better predictor for fine root productivity than for fractional allocation of total NPP to fine roots, suggesting that root productivity is a particularly strong driver of NPP allocation in tropical mountain regions.
|
|
| 4. |
- Humphries, Matthew P., et al.
(författare)
-
A case-matched gender comparison transcriptomic screen identifies eIF4E and eIF5 as potential prognostic markers in male breast cancer
- 2017
-
Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 23:10, s. 2575-2583
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assumptions that underlying biology is similar. Experimental Design: A transcriptomic investigation of male and female breast cancer was performed, confirming transcriptomic data in silico. Biomarkers were immunohistochemically assessed in 697 MBCs (n = 477, training; n = 220, validation set) and quantified in pre- and posttreatment samples from an MBC patient receiving everolimus and PI3K/mTOR inhibitor. Results: Gender-specific gene expression patterns were identified. eIF transcripts were upregulated in MBC. eIF4E and eIF5 were negatively prognostic for overall survival alone (log-rank P = 0.013; HR = 1.77, 1.12-2.8 and P = 0.035; HR = 1.68, 1.03-2.74, respectively), or when coexpressed (P = 0.01; HR = 2.66, 1.26-5.63), confirmed in the validation set. This remained upon multivariate Cox regression analysis [eIF4E P = 0.016; HR = 2.38 (1.18-4.8), eIF5 P = 0.022; HR = 2.55 (1.14-5.7); coexpression P = 0.001; HR = 7.04 (2.22-22.26)]. Marked reduction in eIF4E and eIF5 expression was seen post BEZ235/everolimus, with extended survival. Conclusions: Translational initiation pathway inhibition could be of clinical utility in MBC patients overexpressing eIF4E and eIF5. With mTOR inhibitors that target this pathway now in the clinic, these biomarkers may represent new targets for therapeutic intervention, although further independent validation is required.
|
|
| 5. |
- Jeffery, Lucy
(författare)
-
An Interview with Tim Parkinson
- 2020
-
Ingår i: Journal of Beckett Studies. - : Edinburgh University Press. - 0309-5207 .- 1759-7811. ; 29:2, s. 249-260
-
Tidskriftsartikel (refereegranskat)
|
|
| 6. |
- Jeffery, Lucy
(författare)
-
‘An Old Hullo Out of the Dark’ : Radio Echoes between Samuel Beckett and Harold Pinter
- 2020
-
Ingår i: Historical Journal of Film, Radio and Television. - : Informa UK Limited. - 0143-9685 .- 1465-3451. ; 40:3, s. 516-532
-
Tidskriftsartikel (refereegranskat)abstract
- Radio provided Samuel Beckett and Harold Pinter with new ways of experimenting with voice, silence, and absence. As they maximised radio’s potential to explore the ephemerality of language and non-linear narratives, the works they created were concerned with the medium itself. On radio, Beckett’s silences and Pinter’s pauses create a heightened sense of uncertainty and ambiguity. Their medium-conscious works also provided them with a platform through which they could experiment with their shared frustration with the inaccuracies of language. The article explores Pinter’s interest in Beckett’s work by drawing on Pinter’s letters to Richard Seaver, Patrick Magee, and Mick Goldstein from the Harold Pinter Archive. It then shows how Pinter’s own work is intermedial in its experimentation with new technologies such as radio. By pointing to examples within Pinter’s Landscape (1968) that speak to moments in Beckett’s Embers (1959), the parallels between these writers in their use of radio are identified. Finally, the article suggests that Pinter’s work is not merely derivative of Beckett’s but demonstrates how the radio drama of both writers is underwritten by an intermedial creative process.
|
|
| 7. |
|
|
| 8. |
- Jeffery, Lucy
(författare)
-
Ezra Pound and Constantin Brancusi : sculptural form and the struggle to "make it cohere"
- 2020
-
Ingår i: Word and Image. - : Informa UK Limited. - 0266-6286 .- 1943-2178. ; 36:3, s. 237-247
-
Tidskriftsartikel (refereegranskat)abstract
- This article takes an interdisciplinary approach in order to show the artistic importance of the friendship between Ezra Pound and Constantin Brancusi. It refers to key moments in Pound’s late cantos that evidence his development of a specifically sculptural aesthetic technique. With reference to Pound’s critical writings on the visual arts as well as to his allusions to sculpture and the process of direct carving throughout The Cantos, Pound’s and Brancusi’s work is seen as exemplary of experiments in poetic and sculptural form during the first half of the twentieth century. More specifically, Pound’s invocation of ‘no slither’ and his reference to Brancusi’s Bird in Space (1924, etc.) in Canto CXVII are read as being connected to his struggle to ‘make it cohere’. While Harriet Zinnes and Rebecca Beasley have both analysed Pound’s work in relation to the visual arts, this article sees his interest in the work of Brancusi as something that not only influences the shape of his late cantos, but also is intrinsic to his fraught creative process and sculptural aesthetic.
|
|
| 9. |
- Jeffery, Lucy, et al.
(författare)
-
Introduction
- 2022
-
Ingår i: Green Letters. Studies in Ecocriticism. - : Informa UK Limited. - 1468-8417 .- 2168-1414. ; 26:3, s. 203-209
-
Tidskriftsartikel (refereegranskat)
|
|
| 10. |
- Jeffery, Lucy
(författare)
-
Magda Szabó : Finding Home in the Homeland in Post-1956 Hungary
- 2020
-
Ingår i: SIC - Journal of Literature, Culture and Literary Translation. - : University of Zadar. - 1847-7755. ; 11:3, s. 1-23
-
Tidskriftsartikel (refereegranskat)abstract
- In Iza’s Ballad, Magda Szabó writes about the lives of two doctors who meet and fall in love at university. “Don’t get too involved with politics,” experienced Antal warns a seemingly ingénue Iza. To which she responds: “Politics will be my life as long as I live.” In this brief encounter, Szabó connects the predominant themes of her oeuvre: politics and life, or, to be more specific, Communism and the domestic. In its analysis of Iza’s Ballad (1963), Katalin Street (1969), and The Door (1987), this article illustrates how Szabó’s descriptions of the domestic convey the impact of Hungary’s troubled political history on the concept of the home/homeland. The article illustrates the ways in which Szabó contrasts the relatively comfortable years of Goulash Communism with the hardship endured during WWII, under Rákosi, and during the 1956 Revolution, to convey the lasting effects of the Soviet occupation on the notion of home.
|
|
| 11. |
- Jeffery, Lucy
(författare)
-
Music in Samuel Beckett’s radio play Embers: 'I shouldn’t be hearing that!'
- 2018
-
Ingår i: Radio Journal. - Bristol : Intellect. - 1476-4504 .- 2040-1388. ; 16:2, s. 173-184
-
Tidskriftsartikel (refereegranskat)abstract
- This article explores how Samuel Beckett’s use of music in his 1957 radio play Embers is linked to our understanding of the experience of memory and storytelling. It reconsiders how Beckett’s use of the radio medium both informs and is informed by his lifelong interest in music. Beckett’s well-known attitudes towards storytelling – his struggle to express, interest in ambiguity, and resistance to neat conclusions – are revisited with close attention paid to his attempt to express the ineffable. The article argues that Beckett’s simultaneous need for and resistance to storytelling finds its voice in the impossibility of describing music. It suggests that this implicit tension is essential not only in terms of listening to Embers, but also becomes an increasingly central and knotty element of Beckett’s creative process. Hence, the article claims that Beckett can be read alongside twentieth-century composers such as Arnold Schoenberg and Paul Hindemith. In its use of Theodor Adorno and Vladimir Jankélévitch, the analysis employs musicological readings of Beckett’s radio play to demonstrate how Beckett’s use of music complicates, rather than facilitates, our experience of memory and storytelling.
|
|
| 12. |
- Jeffery, Lucy
(författare)
-
‘Natasha Gordon in Conversation with Lucy Jeffery: “it was around 7.27pm that suddenly diversity walked through the door”’
- 2020
-
Ingår i: ArtsPraxis. - 1552-5236. ; 7b, s. 26-52
-
Tidskriftsartikel (refereegranskat)abstract
- Award-winning playwright Natasha Gordon talks to Lucy Jeffery about her experience as a Caribbean-British actor and playwright whose debut play Nine Night (2018) made her the first black British female playwright to have a play staged in London’s West End. The discussion ranges from Gordon’s own experiences of gendered and racial injustices as a young actor to how these prejudices are evident in the audience demographic of theatres today. It focuses on Nine Night’s exploration of how second-generation, specifically Jamaican-British, immigrants experience tensions concerning identity, belonging, and displacement in the wake of the 2018 Windrush Scandal. As the conversation evaluates the importance of Gordon’s work and visibility on the National Theatre and West End stages, it contributes to the recent underrepresentation of black voices, a concern expressed in the widespread Black Lives Matter and Say Her Name protests that have taken place in America and the UK in 2020. The conversation, which took place at the University of Reading as part of the ‘Race and Performance Today’ series (organised by Jeffery and Matthew McFrederick), also responds to Michael Peters’s (2015) call to challenge the whiteness of curricula in British and American universities.
|
|
| 13. |
- Jeffery, Lucy
(författare)
-
Palliative Care and the Dance of Death in Harold Pinter's Moonlight
- 2021
-
Ingår i: HAROLD PINTER REVIEW-ESSAYS ON CONTEMPORARY DRAMA. - : The Pennsylvania State University Press. - 2473-8433. ; 5, s. 10-16
-
Tidskriftsartikel (refereegranskat)abstract
- As we live through a global pandemic, how do our experiences of healthcare and lockdown influence our engagement with theatre? In what ways is COVID-19 raising concerns about the availability of palliative care? More specifically, how does the work of Harold Pinter help us to understand our relationship toward caretaking and caregiving? This article explores these questions through its engagement with Pinter's 1993 play Moonlight.
|
|
| 14. |
- Jeffery, Lucy
(författare)
-
Pinter as Poet, Pinter as Politician
- 2020
-
Ingår i: The Harold Pinter Review. - : The Pennsylvania State University Press. - 2473-8433 .- 2473-8441. ; 4:1, s. 20-35
-
Tidskriftsartikel (refereegranskat)abstract
- Widely celebrated as one of the greatest playwrights of the second half of the twentieth century, the playwright Harold Pinter is rarely maligned. Pinter's poetry, however, is often sidestepped, with critics generally regarding it as lacking the deftness of his drama. Following on from Basil Chiasson in The Late Harold Pinter: Political Dramatist, Poet and Activist (2017), this article focuses on Pinter's often neglected poetic works. It reads Pinter's poetry in the context of the Cold War, Gulf War, and Iraq War to unpick the political resonances within poems such as “Partners” (1985), “American Football” (1991), “Don't Look” (1995), and “God Bless America” (2003). Through reference to Jean Baudrillard's article “The Gulf War Did Not Take Place” (1991), this article examines Pinter's poetry in light of what we now call “fake news.”
|
|
| 15. |
- Jeffery, Lucy, 1991-
(författare)
-
Samuel Beckett’s brush with the other Mitchell : Painterly Techniques in ‘One Evening’
- 2018
-
Ingår i: Journal of Beckett Studies. - Edinburgh : Edinburgh University Press. - 1759-7811 .- 0309-5207. ; 27:2, s. 175-192
-
Tidskriftsartikel (refereegranskat)abstract
- This paper explores Samuel Beckett's creative relationship with the painter, Joan Mitchell. Through an analysis of Beckett's short text ‘One Evening’ (1980) and Mitchell's painting Tondo (1991), it explores the influence these artists had on each other's work. By drawing comparisons between their aesthetic approaches to their respective medium, it suggests that Beckett's self-reflexive, ambiguous, and carefully coloured late text shares similarities with the work Mitchell was producing around the same time. It uses art historical scholarship and close textual analysis to show how, in some instances, their creative processes reflects that of Paul Cézanne. Beckett's late style is seen as not simply becoming darker, but, like Mitchell's canvases, fluctuates between light and dark, colour and monochrome. The paper proposes that through their considered use of colour both Beckett and Mitchell's work intensifies rather than alleviates the essential tension that drives their aesthetic thought.
|
|
| 16. |
- Jeffery, Lucy
(författare)
-
Samuel Beckett’s use of color in Company: Blue
- 2018
-
Ingår i: Interdisciplinary Literary Studies. - Pennsylvania : Pennsylvania State University Press. - 1524-8429 .- 2161-427X. ; 20:4, s. 507-527
-
Tidskriftsartikel (refereegranskat)abstract
- This article looks at Samuel Beckett's use of color in his late short prose text Company (1980). In its reference to Beckett's “Olympic” notebook, it demonstrates how Beckett's writing process is not merely visual but is also highly dependent upon color in its creation of atmosphere and setting. Instead of seeing Beckett's later work as simply deracinated and monochromatic, it suggests that his prose evidences a painterly style. By analysing Company from an art historical perspective, the article claims that Beckett's use of blue is linked to his comments on paintings by Poussin and da Messina. Saint Augustine's writings on memory are also invoked to understand Beckett's use of color in connection with childhood recollections. The article argues for a reading of Company that uses color to create a self-reflexive narrative that avoids polarization between light and dark, hope and dejection.
|
|
| 17. |
- Rifai, Sami W., et al.
(författare)
-
ENSO Drives interannual variation of forest woody growth across the tropics
- 2018
-
Ingår i: Philosophical Transactions of the Royal Society B: Biological Sciences. - : The Royal Society. - 1471-2970 .- 0962-8436. ; 373:1760
-
Tidskriftsartikel (refereegranskat)abstract
- Meteorological extreme events such as El Niño events are expected to affect tropical forest net primary production (NPP) and woody growth, but there has been no large-scale empirical validation of this expectation. We collected a large high-temporal resolution dataset (for 1-13 years depending upon location) of more than 172 000 stem growth measurements using dendrometer bands from across 14 regions spanning Amazonia, Africa and Borneo in order to test how much month-to-month variation in stand-level woody growth of adult tree stems (NPPstem) can be explained by seasonal variation and interannual meteorological anomalies. A key finding is that woody growth responds differently to meteorological variation between tropical forests with a dry season (where monthly rainfall is less than 100 mm), and aseasonal wet forests lacking a consistent dry season. In seasonal tropical forests, a high degree of variation in woody growth can be predicted from seasonal variation in temperature, vapour pressure deficit, in addition to anomalies of soil water deficit and shortwave radiation. The variation of aseasonal wet forest woody growth is best predicted by the anomalies of vapour pressure deficit, water deficit and shortwave radiation. In total, we predict the total live woody production of the global tropical forest biome to be 2.16 Pg C yr-1, with an interannual range 1.96-2.26 Pg C yr-1 between 1996-2016, and with the sharpest declines during the strong El Niño events of 1997/8 and 2015/6. There is high geographical variation in hotspots of El Niño-associated impacts, with weak impacts in Africa, and strongly negative impacts in parts of Southeast Asia and extensive regions across central and eastern Amazonia. Overall, there is high correlation (r = -0.75) between the annual anomaly of tropical forest woody growth and the annual mean of the El Niño 3.4 index, driven mainly by strong correlations with anomalies of soil water deficit, vapour pressure deficit and shortwave radiation.This article is part of the discussion meeting issue 'The impact of the 2015/2016 El Niño on the terrestrial tropical carbon cycle: patterns, mechanisms and implications'.
|
|
| 18. |
- Shu, Xiang, et al.
(författare)
-
Associations of obesity and circulating insulin and glucose with breast cancer risk : a Mendelian randomization analysis
- 2019
-
Ingår i: International Journal of Epidemiology. - : OXFORD UNIV PRESS. - 0300-5771 .- 1464-3685. ; 48:3, s. 795-806
-
Tidskriftsartikel (refereegranskat)abstract
- Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. Results: All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p = 5.09 x 10(-4)], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p = 4.02 x 10(-4)), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p = 5.05 x 10(-19)) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p = 9.22 x 10(-6)). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. Conclusions: We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.
|
|
| 19. |
|
|
