| 1. |
- Rubulis, Aigars, et al.
(författare)
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Ischemia-induced repolarization response in relation to the size and location of the ischemic myocardium during short-lasting coronary occlusion in humans.
- 2010
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Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736 .- 1532-8430. ; 43:2, s. 104-112
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The ventricular repolarization (VR) response to short-lasting coronary occlusion has been characterized by 3-dimensional vectorcardiography (VCG) in humans; the T vector loop becomes distorted and more circular. The purpose of this study was to relate these changes to the size of the myocardium at risk (MAR) and its location. METHODS: Continuous VCG was applied during transient coronary occlusion in 35 elective angioplasty patients, and the size of the MAR was estimated by single-photon emission computed tomography. Three VR aspects were assessed at baseline vs maximum ischemia: the ST segment, the T vector angles, and the T vector loop morphology. RESULTS: The T loop morphology changes were significantly associated with MAR size, but also dependent of its location. In contrast, the early phase of VR reflected by the ST segment responded to acute ischemia in relation to the MAR size independent of location. CONCLUSION: The VR changes were related both to the size and the location of the MAR and most pronounced during occlusion of the left anterior descending artery.
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| 2. |
- Aboagye, Emmanuel, et al.
(författare)
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Individual preferences for physical exercise as secondary prevention for non-specific low back pain : a discrete choice experiment
- 2017
-
Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Exercise is effective in improving non-specific low back pain (LBP). Certain components of physical exercise, such as the type, intensity and frequency of exercise, are likely to influence participation among working adults with non-specific LBP, but the value and relative importance of these components remain unknown. The study's aim was to examine such specific components and their influence on individual preferences for exercise for secondary prevention of non-specific LBP among working adults. Methods: In a discrete choice experiment, working individuals with non-specific LBP answered a webbased questionnaire. Each respondent was given ten pairs of hypothetical exercise programs and asked to choose one option from each pair. The choices comprised six attributes of exercise (i.e., type of training, design, intensity, frequency, proximity and incentives), each with either three or four levels. A conditional logit regression that reflected the random utility model was used to analyze the responses. Results: The final study population consisted of 112 participants. The participants' preferred exercise option was aerobic (i.e., cardiovascular) rather than strength training, group exercise with trainer supervision, rather than individual or unsupervised exercise. They also preferred high intensity exercise performed at least once or twice per week. The most popular types of incentive were exercise during working hours and a wellness allowance rather than coupons for sports goods. The results show that the relative value of some attribute levels differed between young adults (age <= 44 years) and older adults (age <= 45 years) in terms of the level of trainer supervision required, exercise intensity, travel time to exercise location and financial incentives. For active study participants, exercise frequency (i.e., twice per week, 1.15; CI: 0.25; 2.06) influenced choice of exercise. For individuals with more than one child, travel time (i.e., 20 minutes, - 0.55; CI: 0.65; 3.26) was also an influential attribute for choice of exercise, showing that people with children at home preferred to exercise close to home. Conclusions: This study adds to our knowledge about what types of exercise working adults with back pain are most likely to participate in. The exercise should be a cardiovascular type of training carried out in a group with trainer supervision. It should also be of high intensity and preferably performed twice per week during working hours. Coupons for sports goods do not appear to motivate physical activity among workers with LBP. The findings of the study could have a substantial impact on the planning and development of exercise provision and promotion strategies to improve non-specific LBP. Providers and employers may be able to improve participation in exercise programs for adults with non-specific LBP by focusing on the exercise components which are the most attractive. This in turn would improve satisfaction and adherence to exercise interventions aimed at preventing recurrent non-specific LBP.
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| 3. |
- Alling, Christer, et al.
(författare)
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Anionic glycerophospholipids in platelets from alcoholics
- 1986
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Ingår i: Drug and Alcohol Dependence. - : Elsevier BV. - 1879-0046 .- 0376-8716. ; 16:4, s. 309-320
-
Tidskriftsartikel (refereegranskat)abstract
- Studies on ethanol-exposed animals have revealed changes in anionic phospholipids in brain membranes. The intention of this study was to investigate whether there was a similar effect on man. Assuming platelets to be an adequate model for CNS synaptosomes, concentration and fatty acid composition of anionic phospholipids, phosphatidylserine (PS) and phosphatidylositol (PI) in the platelet membrane from alcoholics after a debauche period were examined and compared to controls. Ethanol effects on neutral lipids were also analysed in order to obtain a comprehensive view. No quantitative difference was found in anionic phospholipids between alcoholics and controls. Fatty acid composition of individual phospholipids revealed significant changes which were more obvious in neutral phospholipids than in anionic. Oleic acid was increased and linoleic and arachidonic acids were decreased. After 1 week of detoxification, the abnormalities did not decrease, on the contrary they increased and total phospholipid concentration per platelet was significantly higher than in controls. It is concluded that the ethanol toxicity on bone marrow hampers the use of platelets as a model for synaptosomes but that the observed lipid abnormalities might play a major role in the impairment of platelet function in alcoholics.
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| 4. |
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| 5. |
- Dahlberg, Pia, et al.
(författare)
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Accelerated QT adaptation following atropine-induced heart rate increase in LQT1 patients versus healthy controls: A sign of disturbed hysteresis.
- 2022
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Ingår i: Physiological reports. - : Wiley. - 2051-817X. ; 10:21
-
Tidskriftsartikel (refereegranskat)abstract
- Hysteresis, a ubiquitous regulatory phenomenon, is a salient feature of the adaptation of ventricular repolarization duration to heart rate (HR) change. We therefore compared the QT interval adaptation to rapid HR increase in patients with the long QT syndrome type 1 (LQT1) versus healthy controls because LQT1 is caused by loss-of-function mutations affecting the repolarizing potassium channel current IKs , presumably an important player in QT hysteresis. The study was performed in an outpatient hospital setting. HR was increased in LQT1 patients and controls by administering an intravenous bolus of atropine (0.04mg/kg body weight) for 30s. RR and QT intervals were recorded by continuous Frank vectorcardiography. Atropine induced transient expected side effects but no adverse arrhythmias. There was no difference in HR response (RR intervals) to atropine between the groups. Although atropine-induced ΔQT was 48% greater in 18 LQT1 patients than in 28 controls (p<0.001), QT adaptation was on average 25% faster in LQT1 patients (measured as the time constant τ for the mono-exponential function and the time for 90% of ΔQT; p<0.01); however, there was some overlap between the groups, possibly a beta-blocker effect. The shorter QT adaptation time to atropine-induced HR increase in LQT1 patients on the group level corroborates the importance of IKs in QT adaptation hysteresis in humans and shows that LQT1 patients have a disturbed ultra-rapid cardiac memory. On the individual level, the QT adaptation time possibly reflects the effect-size of the loss-of-function mutation, but its clinical implications need to be shown.
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| 6. |
- Edo Giménez, Mar, et al.
(författare)
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Fördjupad analys av plast i hushållens restavfall och dess potential till ökad materialåtervinning och minskad klimatpåverkan
- 2023
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- För att nå uppsatta nationella klimatmål behöver avfalls- och energisektorn minska klimatutsläppen från energiåtervinningen av avfall som idag står för omkring 75 procent av de totala klimatutsläppen från el- och fjärrvärmesektorn. Restavfall från hushåll och liknande verksamheter står för drygt 30 procent av de totala avfallsmängderna som idag går till energiåtervinning i Sverige. En betydande andel av hushållens restavfall utgörs av plastförpackningar som står för de största klimatutsläppen vid energiåtervinning. Därutöver förekommer andra avfallsslag i vilka plast utgör ett av flera material som exempelvis pappersförpackningar som ofta innehåller en vätskebarriär i plast samt blöjor och andra sanitetsprodukter. Fossilt kol som bidrar till klimatpåverkan vid energiåtervinning av restavfall förekommer också i material som man inte uppfattar som plaster, till exempel konstläder, syntetiska textilier och gummi. Idag har vi stor kunskap om avfallssammansättningen i hushållens restavfall eftersom kommuner på regelbunden basis genomför plockanalyser på avfallet. Dock är kunskapen idag begränsad vad gäller klimatpåverkan från restavfallets ingående avfallsfraktioner. Detta med hänsyn tagen till att olika plaster släpper ut olika mycket koldioxid beroende på faktorer såsom polymertyp, innehåll av smuts och vätska, typ av fyllmedel och andel plast i den aktuella avfallsfraktionen. Det har gjorts projekt i vilka man uppskattat klimatpåverkan från olika avfallsfraktioner i hushållens restavfall. Gemensamt för dessa rapporter är att schabloner använts eller antaganden gjorts kring materialsammansättningen för flera avfallsfraktioner för att uppskatta klimatpåverkan samt att data över klimatpåverkan i vissa fall är aggregerad där summan av flera underliggande avfallsfraktioner redovisas. Därutöver finns det också kunskapsluckor kring förekomsten av vilka olämpliga ämnen som olika avfallsfraktioner i restavfallet innehåller. Olämpliga ämnen är sådana ämnen som finns på kandidatförteckningen eller kan vara ämnen som på annat sätt kan försvåra materialåtervinningen. Sammantaget bidrar detta till osäkerheter kring potentialen för olika åtgärder som exempelvis ökade och förbättrade källsorteringsmöjligheter, eftersortering, kemisk återvinning samt CCU och CCS, för att minska klimatpåverkan från energiåtervinning av hushållens restavfall. Syftet med projektet är att ge en ökad förståelse för vilken klimatpåverkan ingående avfallsfraktioner i hushållens restavfall har. Detta genom att analysera avfallsfraktioner innehållande plast med avseende på bl.a. andelen fossilt respektive biogent kol, polymertyp samt innehåll av ämnen på kandidatlistan och annat oönskat material. Baserat på erhållna resultat kan följande slutsatser från projektet dras: • Hårdplastförpackningar och mjukplastförpackningar vilka omfattas av producentansvar står för 35–43 procent av de fossila koldioxidutsläppen vid förbränning av hushållens restavfall. • Fraktionen Övrig plast, som består av plast som inte faller under något producentansvar, utgör 12–17 procent av de fossila koldioxidutsläppen vid förbränning av hushållens restavfall. Denna avfallsfraktion innehåller ämnen på kandidatlistan vilka kan vara ett hinder vid materialåtervinning. • Fraktionen Övrigt brännbart står för 11–12 procent av de fossila koldioxidutsläppen vid förbränning av hushållens restavfall och innehåller ämnen på kandidatlistan (ftalater) vilket kan vara ett hinder vid materialåtervinning. Övrigt brännbart innehåller material som exempelvis leksaker, gummihandskar, hår, skor, mattor m.m. • Blöjor bidrar till 6–9 procent av de totala fossila koldioxidutsläppen vid förbränning av hushållens restavfall. Blöjor och sanitetsprodukter omfattas inte av producentansvar och består av många olika sorters material. • Textilier utgör 3–8 procent av de fossila koldioxidutsläppen vid förbränning av hushållens restavfall och av dessa textilier är omkring en tredjedel återanvändningsbara kläder, vilka det idag finns insamlingssystem för. Några olämpliga ämnen som försvårar materialåtervinning kunde inte identifieras. Från och med 2025 kommer kommunerna samla in uppkommet textilavfall separat. • Tillsammans med fraktionen Blöjor kommer avfallsfraktionerna Övrig plast och Övrigt brännbart att stå för de största fossila koldioxidutsläppen från energiåtervinning av hushållens restavfall när fastighetsnära insamling av förpackningar är på plats. Något producentansvar förekommer idag inte för dessa avfallsfraktioner och förekommande material är svåra att materialåtervinna då det innehåller många olika sorters polymerer. • En jämförelse av klimatpåverkan från avfallsfraktioner i hushållens restavfall gentemot tidigare studier är svårt att göra. En anledning till denna slutsats är att tidigare studier redovisar aggregerade data över klimatpåverkan innehållande flera avfallsfraktioner som var och en bidrar till klimatpåverkan vid förbränning. En annan orsak är skillnader i restavfallets avfallssammansättning mellan studier. Utifrån resultatet som baseras på faktiska mätningar för respektive avfallsslag, finns nu data från samtliga ingående restavfallsfraktioner i hushållens restavfall som bidrar till klimatpåverkan i samband med förbränning. Detta gör det möjligt att uppskatta klimatpåverkan från restavfallet och potentialen i olika klimatåtgärder utifrån olika kommuners specifika avfallssammansättning.
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| 7. |
- Elsass, Peter, et al.
(författare)
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The local within the global
- 2006
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Ingår i: Nordic Psychology. - 1901-2276 .- 1904-0016. ; 58:1
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Essen-Gustavsson, Birgitta, et al.
(författare)
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Analysis of Acid-Soluble Glycogen in Pork Extracts of Two PRKAG3 Genotypes by H-1 Liquid-State NMR Spectroscopy and Biochemical Methods
- 2011
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Ingår i: Journal of Agricultural and Food Chemistry. - : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 59, s. 11895-11902
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Tidskriftsartikel (refereegranskat)abstract
- Meat extracts with acid-soluble glycogen (macroglycogen) from M. longissmus dorsi of carriers and noncarriers of the PRKAG3 mutation (RN- and rn(+) genotype) were analyzed by both H-1 liquid-state NMR spectroscopy and a biochemical method. The H-1 NMR analysis revealed that shorter polymers (dimers, trimers, etc.) of alpha-1,4-linked glucose were generated 24-48 h post-mortem. This is not possible to elucidate with the biochemical method, by which only the total amount of hydrolyzed glucose residues is determined. The shorter polymers were primarily formed in carriers of the PRKAG3 mutation, suggesting different postmortem glycogen degradation mechanisms in the two genotypes.
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| 9. |
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| 10. |
- Göransson, Elisabet, et al.
(författare)
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Connecting the Case Studies : Editorial Methods and the Editorial Circle Model
- 2016
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Ingår i: The Arts of Editing Medieval Greek and Latin : a Casebook - a Casebook. - 0082-5328. - 9780888442031 ; 203, s. 400-429
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Bokkapitel (refereegranskat)abstract
- The concluding study offers reflections and a synthetic analysis of all the studies in the casebook, presented from the perspective of a "first reader". The pattern of external factors, editorial challenges, methodologies and forms of presentation is discussed. It offers an interpretation of how the body of case studies manifest a wide spectrum of methodologies. The case studies are categorized through two suggested models, one expressed as a map of varieties of editions produced using different methods and approaches; the other as a hermeneutic editorial circle revolving around four interrelated factors every editor has to take into consideration. The map sets out to clarify the editorial task, while the editorial circle problematizes it by bringing into the equation experiential parameters often omitted in theoretical discussions.
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| 11. |
- Hellner, Britt Marie, et al.
(författare)
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Systematiskt arbete för äldres säkerhet : om fall, trafikolyckor och bränder
- 2007
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Bok (refereegranskat)abstract
- Äldre personer är överrepresenterade i nästan alla olyckor. Förutom stort personligt lidande för individen leder skadorna ofta till omfattande kostnader för samhället. Därför har Räddningsverket och IMS/Socialstyrelsen tilsammans med forskare vid Umeå Universitet, Karlstad Universitet, Krolinska Insitutet, FoU Välfärd Örebro samt Vägverket gemensamt sammaställt denna bok. Syftet är att inspirera och vägleda ett systematiskt arbete i samhället för att öka säkerheten och minska skadorna till följd av olyckor bland äldre. Boken riktar sig till verksamma inom vård och omsorg för äldre, tjänstemän och politiker på olika nivåer i samhället
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| 12. |
- Jensen, Brian, 1948-, et al.
(författare)
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Introduction
- 2016
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Ingår i: Ars Edendi Lecture Series. - Stockholm : Stockholm University Press. - 9789176350393 - 9789176350362 ; , s. vii-xi
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Bokkapitel (refereegranskat)abstract
- The introduction presents the seven contributions on the arts of editing in the fourth volume of the Ars Edendi Lecture Series.
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| 13. |
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| 14. |
- Jensen, Gunilla, et al.
(författare)
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Theoretical understanding and methodological challenges in accessibility assessments, focusing the environmental component: an example from travel chains in urban public bus transport.
- 2002
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Ingår i: Disability and Rehabilitation. - : Informa UK Limited. - 0963-8288 .- 1464-5165. ; 24:5, s. 231-242
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: In order to increase the theoretical understanding of the concept of accessibility, this paper reports the results from an exploration of methodological difficulties inherent in systematic accessibility assessments of single persons' travel chains in urban public bus transport. In addition, Special Transport Service (STS) travellers' perception of environmental demands in public transport are reported. METHODS: This study was designed to explore the environmental component in accessibility problems systematically. Twenty persons entitled to STS were recruited in order to travel by low-floor bus, Service Route Traffic (SRT) or STS. Two different methods were chosen. Critical incidents were collected during participant observation, and by means of a pilot instrument based on the Enabler Concept independent environmental assessments were performed. RESULTS: Not all environmental details registered during the participant observations were in agreement with the independent environmental assessment, and different reasons for the disagreements were reported. In addition, participants travelling by STS gave information about what hindered them from using conventional public transport. CONCLUSIONS: The theoretical understanding behind accessibility assessments has benefited from the methodological challenges mapped out in this study. In order to interpret accessibility, the individual perspective as well as the population perspective are necessary, which means that complementary methods are needed.
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| 15. |
- Kerdsongpanya, Sit, et al.
(författare)
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Anomalously high thermoelectric power factor in epitaxial ScN thin films
- 2011
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Ingår i: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 99:23, s. 232113-
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Tidskriftsartikel (refereegranskat)abstract
- Thermoelectric properties of ScN thin films grown by reactive magnetron sputtering on Al2O3(0001) wafers are reported. X-ray diffraction and elastic recoil detection analyses show that the composition of the films is close to stoichiometry with trace amounts (similar to 1 at. % in total) of C, O, and F. We found that the ScN thin-film exhibits a rather low electrical resistivity of similar to 2.94 mu Omega m, while its Seebeck coefficient is approximately similar to-86 mu V/K at 800 K, yielding a power factor of similar to 2.5 x 10(-3) W/mK(2). This value is anomalously high for common transition-metal nitrides.
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| 16. |
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| 17. |
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| 18. |
- Malcovati, Luca, et al.
(författare)
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SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
- 2015
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 126:2, s. 233-241
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Tidskriftsartikel (refereegranskat)abstract
- Refractory anemia with ring sideroblasts (RARS) is a myelodysplastic syndrome (MDS) characterized by isolated erythroid dysplasia and 15% or more bone marrow ring sideroblasts. Ring sideroblasts are found also in other MDS subtypes, such as refractory cytopenia with multilineage dysplasia and ring sideroblasts (RCMD-RS). A high prevalence of somatic mutations of SF3B1 was reported in these conditions. To identify mutation patterns that affect disease phenotype and clinical outcome, we performed a comprehensive mutation analysis in 293 patients with myeloid neoplasm and 1% or more ring sideroblasts. SF3B1 mutations were detected in 129 of 159 cases (81%) of RARS or RCMD-RS. Among other patients with ring sideroblasts, lower prevalence of SF3B1 mutations and higher prevalence of mutations in other splicing factor genes were observed (P < .001). In multivariable analyses, patients with SF3B1 mutations showed significantly better overall survival (hazard ratio [HR], .37; P = .003) and lower cumulative incidence of disease progression (HR = 0.31; P = .018) compared with SF3B1-unmutated cases. The independent prognostic value of SF3B1 mutation was retained in MDS without excess blasts, as well as in sideroblastic categories (RARS and RCMD-RS). Among SF3B1-mutated patients, coexisting mutations in DNA methylation genes were associated with multilineage dysplasia (P = .015) but had no effect on clinical outcome. TP53 mutations were frequently detected in patients without SF3B1 mutation, and were associated with poor outcome. Thus, SF3B1 mutation identifies a distinct MDS subtype that is unlikely to develop detrimental subclonal mutations and is characterized by indolent clinical course and favorable outcome.
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| 19. |
- Malmström, Johan, et al.
(författare)
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Proteoglycan and proteome profiling of central human pulmonary fibrotic tissue utilizing miniaturized sample preparation : a feasibility study
- 2002
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Ingår i: Proteomics. - 1615-9861. ; 2:4, s. 394-404
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to isolate fibrotic cells from human lung biopsies taken from different central pulmonary locations. A comparison was made of cell morphology, proteoglycan- and protein-expression in mesenchymal cell cultures obtained from human bronchial biopsies from patients with asthmatic-like disorders. We isolated viable cells from 10 out of the 12 biopsies. The fibroblast-like cells were positive for the biomarker a-smooth muscle actin, indicating that the cells were in an activated state. Two different types of fibroblast-like cells were observed from human pulmonary connective tissue; one of contractile type with lamellipodia that facilitate migration and a second cell type with an increased cell size, which most likely is of a synthetic phenotype. This is the first evidence of alterations in the proteoglycan expression pattern of versican, perlecan, biglycan and decorin which can be linked to the pathophysiological state of asthmatics proven by a combination of solid-phase extraction by reversed phase and by peptide mass fingerprinting using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Protein expression analysis using two-dimensional electrophoresis was interfaced to miniaturized sample preparation techniques using microcapillary extraction. Four protein groups were identified; cytoskeletal, adhesion, scavenger and metabolic proteins. These patient's proteomes showed a high degree of heterogeneity between patients but larger homogeneity within biopsies derived from different locations of the same patient.
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| 20. |
- Reverté, Sara, et al.
(författare)
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National records of 3000 European bee and hoverfly species : A contribution to pollinator conservation
- 2023
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Ingår i: Insect Conservation and Diversity. - 1752-458X. ; 16:6, s. 758-775
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Tidskriftsartikel (refereegranskat)abstract
- Pollinators play a crucial role in ecosystems globally, ensuring the seed production of most flowering plants. They are threatened by global changes and knowledge of their distribution at the national and continental levels is needed to implement efficient conservation actions, but this knowledge is still fragmented and/or difficult to access. As a step forward, we provide an updated list of around 3000 European bee and hoverfly species, reflecting their current distributional status at the national level (in the form of present, absent, regionally extinct, possibly extinct or non-native). This work was attainable by incorporating both published and unpublished data, as well as knowledge from a large set of taxonomists and ecologists in both groups. After providing the first National species lists for bees and hoverflies for many countries, we examine the current distributional patterns of these species and designate the countries with highest levels of species richness. We also show that many species are recorded in a single European country, highlighting the importance of articulating European and national conservation strategies. Finally, we discuss how the data provided here can be combined with future trait and Red List data to implement research that will further advance pollinator conservation.
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| 21. |
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| 22. |
- Svenugnsson, Elisabet, et al.
(författare)
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Decreased levels of autoantibodies against apolipoprotein B-100 antigens are associated with cardiovascular disease in systemic lupus erythematosus.
- 2015
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Ingår i: Clinical and Experimental Immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 181:3, s. 417-426
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Tidskriftsartikel (refereegranskat)abstract
- Increased production of autoantibodies is a characteristic feature of systemic lupus erythematosus (SLE) and there is evidence that several of these autoantibodies may contribute to the increased cardiovascular disease (CVD) in SLE. Autoantibodies against the apolipoprotein (apo) B-100 peptides p45 and p210 have been associated with a lower CVD risk in non-SLE cohorts. The aim of the present study was to investigate how SLE affects the occurrence of these potentially protective autoantibodies. The study cohort consisted of 434 SLE patients and 322 age and sex-matched population controls. Antibodies against native and malondialdehyde (MDA)-modified p45 and p210 were measured by ELISA. SLE patients had significantly lower levels of p210 IgG and p45 IgM (both the native and MDA-modified forms). SLE patients with manifest CVD (myocardial infarction, ischemic cerebrovascular disease or peripheral vascular disease) had lower levels p210 IgG and p45 IgM than SLE patients without CVD. Decreased levels of these autoantibodies were also observed in SLE patients with permanent organ damage as assessed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI). The present findings show that patients with SLE, a condition generally characterized by abundance of autoantibodies of multiple specificities, have reduced levels of antibodies against the apo B-100 antigens p45 and p210 and that the levels of these antibodies are further reduced in SLE patients with CVD. These observations suggest the possibility that an impaired antibody-mediated removal of damaged LDL particles may contribute to the development of vascular complications and organ damage in SLE. This article is protected by copyright. All rights reserved.
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| 23. |
- Säll-Hansson, Karin, et al.
(författare)
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Efficacy of mecobalamin (vitamin B12) in the treatment of long-term pain in women diagnosed with fibromyalgia : protocol for a randomised, placebo-controlled trial
- 2023
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:3
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Fibromyalgia causes long-term pain. It affects at least 2% of the population, the majority being women. In addition, extended symptoms corresponding to vitamin B12 deficiency occur. Findings from several studies have indicated that vitamin B12 may be a possible treatment for pain in fibromyalgia. The aim of the proposed study is to evaluate whether vitamin B12 decreases pain sensitivity and the experience of pain (ie, hyperalgesia and allodynia) in women with fibromyalgia.METHODS AND ANALYSIS: The study is a randomised, placebo-controlled, single-blind, clinical trial with two parallel groups which are administered mecobalamin (vitamin B12) or placebo over 12 weeks. 40 Swedish women aged 20-70 years with an earlier recorded diagnosis of fibromyalgia are randomised into the placebo group or the treatment group, each consisting of 20 participants. Outcomes consist of questionnaires measured at baseline and after 12 weeks of treatment. A final re-evaluation will then follow 12 weeks after treatment ends. The primary outcome is tolerance time, maximised to 3 min, which is assessed using the cold pressor test. In order to broaden the understanding of the lived experience of participants, qualitative interviews will be conducted using a phenomenological approach on a lifeworld theoretical basis (reflective lifeworld research approach).ETHICS AND DISSEMINATION: The protocol for the study is approved by the local ethical committee at Linkoping (EPM; 2018/294-31, appendices 2019-00347 and 2020-04482). The principles of the Helsinki Declaration are followed regarding oral and written consent to participate, confidentiality and the possibility to withdraw participation from the study at any time. The results will primarily be communicated through peer-reviewed journals and conferences.TRIAL REGISTRATION NUMBER: NCT05008042.
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| 24. |
-
The Arts of Editing Medieval Greek and Latin : a Casebook
- 2016
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- With the triumph of the codex, medieval literature became more deeply hermeneutic in character. A vast range of texts, in various languages and genres, were not only copied with the commentaries and glosses of ancient tradition, but also underwent continuous reworking and transformation. Indeed, the very act of transcribing texts into a manuscript was often an incentive to rewrite them. This practice resulted in a bewildering number of textual versions that lived alongside their originals, and sometimes displaced them, but were nevertheless fundamental to their transmission and interpretation, often resulting in complex textual layers.All of them, from commentaries on biblical books, hymns, or sequences to texts for liturgical use with many local versions, from model sermon collections to florilegia and encyclopaedic works, came to encompass multiple paratextual and intermedial forms, be it in the guise of other texts or images or music, all with their own histories of transmission.Despite the importance in the development of medieval thought and culture their widespread dissemination evinces, these works have remained largely unedited, or unavailable in reliable modern editions. One reason for this has surely been that they were seen as merely functional texts and regarded as less important than the canonical texts. Yet the sheer number of different versions also makes them resistant to traditional and well-established editorial protocols.Issuing from Stockholm University's Ars edendi research programme (2008–2015), The Arts of Editing Medieval Greek and Latin draws together eighteen case studies covering typical medieval genres such as commentaries and glosses, liturgical texts, model sermons, and anthologies. Exploiting examples not typically discussed in manuals of textual criticism, these essays describe the challenges and opportunities in producing single-manuscript editions or editions involving large numbers of witnesses, editing different versions of the same author's text or anthologies containing the works of multiple authors, as well as in capturing stages of textual genesis and textual variability, relating text to image, and harnessing digital tools. A closing chapter seeks to trace common threads as well as differences, offering reflections on broader questions of editorial theory and practice.
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| 25. |
- Tunon, Håkan, et al.
(författare)
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Grattis Moder Jord!
- 2010
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Ingår i: Svenska Dagbladet/Brännpunkt. ; 22 april 2010
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 26. |
- Vahedi, Farzad, et al.
(författare)
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Instability of repolarization in LQTS mutation carriers compared to healthy control subjects assessed by vectorcardiography
- 2013
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Ingår i: Heart Rhythm. - : Elsevier BV. - 1547-5271 .- 1556-3871. ; 10:8, s. 1169-1175
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Potassium channel dysfunction in congenital and acquired forms of long QT syndrome types 1 and 2 (LQT1 and LQT2) increases the beat-to-beat variability of the (IT interval. OBJECTIVE To study about the little known variability (instability) of other aspects of ventricular repolarization (VR) in humans by using vectorcardiography. METHODS Beat-to-beat analysis was performed regarding vectorcardiography derived RR, QRS, and QT intervals, as well as T vector- and T vector loop-based parameters during 1-minute recordings of uninterrupted sinus rhythm at rest in 41 adult LQT1 (n = 31) and LQT2 (n = 10) mutation carriers and 41 age- and sex-matched control subjects. The short-term variability for each parameter, describing the mean orthogonal distance to the line of identity on the Poincare plot, was calculated. RESULTS Mutation carriers showed significantly larger (by a factor 2) instability in most VR parameters compared to controls despite higher instantaneous heart rate variability (STVRR) in the control group. The longer the (IT interval, the greater was its instability, and the instability of VR dispersion measures. CONCLUSIONS A greater instability of most aspects of VR already at rest seems to be a salient feature in both LQT1 and LQT2, which might pave the way for early afterdepolarizations and torsades de pointes ventricular tachycardia. In contrast, no signs of increased VR dispersion per se were observed in mutation carriers.
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| 27. |
- Wigren, Maria, et al.
(författare)
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Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis
- 2018
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 270, s. 1-7
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: There is convincing evidence that adaptive immune responses affect the development of atherosclerosis and thrombosis and several autoimmune diseases are associated with increased cardiovascular risk. However, our understanding of the underlying mechanisms remains limited. We investigated how biomarkers reflecting four aspects of autoimmunity: apoptosis, inflammation, tissue degradation and repair, associate with cardiovascular disease (CVD) in subjects with systemic lupus erythematosus (SLE). Methods: We investigated 484 well-characterized SLE patients, 69 of whom had CVD (coronary artery disease, cerebrovascular disease or peripheral artery disease), and 253 controls. Occurrence of carotid plaques was investigated with ultrasound. Plasma levels of biomarkers reflecting apoptosis (Fas, TNF receptor 1, TRAIL receptor 2), inflammation (IL-6, IL-8, monocyte chemotactic protein-1), tissue degradation (matrix metalloproteinase (MMP)-1, MMP-3, MMP-7), and tissue repair (platelet-derived growth factor, epidermal growth factor and stem cell factor) were analyzed by Proximity Extension Assay. Results: Subjects with SLE had markedly elevated plasma levels of biomarkers reflecting apoptosis, inflammation and tissue degradation as compared to controls. SLE patients with CVD had higher levels of Fas, TNF receptor 1, TRAIL receptor 2, MMP-1 and -7 than those without CVD. The same associations were found for the presence of a carotid plaque. When controlling for the factors included in the Framingham risk score, all biomarkers except MMP-1 remained associated with the presence of a carotid plaque, while only TRAIL receptor 2 levels remained significantly associated with CVD. Conclusions: Our findings argue that the cardiovascular risk in SLE is associated with increased cell death by apoptosis and tissue degradation.
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| 28. |
- Žukauskaitė, Agnė, et al.
(författare)
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Microstructure and Dielectric Properties of Piezoelectric Magnetron Sputtered w-ScxAl1-xN thin films
- 2012
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Ingår i: Journal of Applied Physics. - : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 111:9, s. 093527-
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Tidskriftsartikel (refereegranskat)abstract
- Piezoelectric wurtzite ScxAl1-xN (x=0, 0.1, 0.2, 0.3) thin films were epitaxially grown by reactive magnetron co-sputtering from elemental Sc and Al targets. Al2O3(0001) wafers with TiN(111) seed and electrode layers were used as substrates. X-ray diffraction shows that an increase in the Sc content results in the degradation of the crystalline quality. Samples grown at 400 °C possess true dielectric behavior with quite low dielectric losses and the leakage current is negligible. For ScAlN samples grown at 800 °C, the crystal structure is poor and leakage current is high. Transmission electron microscopy with energy dispersive x-ray spectroscopy mapping shows a mass separation into ScN-rich and AlN-rich domains for x≥0.2 when substrate temperature is increased from 400 to 800 °C. The piezoelectric response of epitaxial ScxAl1-xN films measured by piezoresponse force microscopy and double beam interferometry shows up to 180% increase by the addition of Sc up to x=0.2 independent of substrate temperature, in good agreement with previous theoretical predictions based on density-functional theory.
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