| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
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Att studera funktionshinder och åldrande : en bok om metoderfarenheter
- 2015
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med den här boken är att presentera och reflektera över metoder som tillämpades inom ett forskningsprogram där funktionshinder och åldrande studerades1 och som var förlagt till Nationella institutet för forskning om äldre och åldrande (NISAL) vid Linköpings universitet. Inom programmet tillämpades ett antal olika kvalitativa ansatser och metoder, inom ramen för varierande betingelser. Det är mot bakgrund av dessa metoderfarenheter som vi skrivit denna bok. Fokus är inte i första hand på vad vi kommit fram till genom våra studier utan hur vi gjort det och på de erfarenheter, möjligheter och utmaningar som olika metoder varit förknippade med. Våra diskussioner handlar också om vilka praktiska och metodologiska slutsatser som kan dras av våra erfarenheter och iakttagelser. Vi reflekterar över kvalitativa metoder, med exempel från frågor om urval, intervjumetoder, forskarrollen och teoriskapande.Vad innebär det att leva ett långt liv och åldras med en fysisk eller intellektuell funktionsnedsättning som man haft i många år? Det var den övergripande frågan som studerades inom olika delstudier i det forskningsprogram inom vilket vi gjort våra erfarenheter och som belyses i bokens kapitel. Programmet tillämpade ett livsloppsperspektiv, vilket betyder att innebörden i funktionshinder och åldrande förstås och tolkas utifrån hela livets dynamik, och där åldrandet ses som en livslång process. Tidsbegreppet är centralt i denna ansats och det är ett mångdimensionellt begrepp där både individens tid och den historiska tiden tas i beaktande (Jeppsson Grassman 2008a; Jeppsson Grassman & Whitaker 2013). Det betyder också att vi i boken diskuterar livsloppet som metodologiskt verktyg, både dess möjligheter och svårigheter, med utgångspunkt från våra erfarenheter.Idag finns det stort antal metodböcker som behandlar kvalitativa metoder (se till exempel Gubrium & Holstein 2002; Denzin & Lincoln 2011; Silverman 2011). Det kan vara fråga om allmänt inriktade handböcker, men numera inte så sällan också böcker som fokuserar på speciella discipliner inom samhällsvetenskap eller omvårdnadsforskning, etc. Det kan också handla om metodböcker, kapitel eller artiklar, som knyter an till speciella grupper och de metodfrågor som därigenom kan aktualiseras (se till exempel Nind 2008; Wenger 2002 ). Det har hittills inte funnits någon speciell metodbok inom just vårt studerade område. De perspektiv vi har tillämpat har hittills också varit ganska outforskade. Men ett lika viktigt argument är att de flesta metodböcker beskriver hur man gör och inte, som i vårt fall, betingelserna kring – möjligheterna och utmaningarna – och konsekvenserna av att använda olika metoder. För att ta del av forskning om de sistnämnda frågorna får man som regel gå till metodkapitel i avhandlingar, vilka ibland, men inte alltid, belyser de här frågorna. Det finns naturligtvis också vetenskapliga artiklar som tar upp metodologiska erfarenheter på olika sätt. Men här saknas ofta en mer övergripande bild.Krävs det egentligen några speciella metoder för att studera funktionshinder och åldrande? Nej, det kan vara svårt att hävda. Men vårt område är förknippat med speciella betingelser, vilka får betydelse för den forskning man vill genomföra. Det handlar om ett etiskt känsligt område. Frågor som berör funktionshinder och livet för människor med funktionsnedsättningar är också påtagligt ”normativt impregnerat” när det gäller vilka perspektiv som anses vara politiskt korrekta för forskningen och beträffande vem som ”har rätt” att forska inom området överhuvudtaget. I flera av bokens kapitel reflekterar författarna över den här typen av frågor. Men ”det speciella” är inte vårt syfte i sig. Istället menar vi att vi, genom att belysa våra frågor och perspektiv mot bakgrund av vårt speciella område och dess betingelser och våra studerade grupper, illustrerar allmänna metodfrågor och deras praktiska implikationer. Det specifika kan ofta tydliggöra allmängiltiga mönster. Samtidigt – och det är viktigt att understryka – är de metodologiska frågor vi tar upp sådana som sällan diskuteras överhuvudtaget och de grupper som intervjuats kommer sällan till tals.Boken riktar sig främst till högskolestudenter inom samhälls- och beteendevetenskap, liksom till omsorgsutbildningar och vårdvetenskap, mer specifikt i samband med metodutbildning och uppsatsskrivande. Men även doktorander och mer etablerade forskare hoppas och tror vi kan ha användning av våra metodologiska reflektioner. Vår bedömning är också att de erfarenheter som redovisas kan vara av praktisk nytta för yrkesverksamma inom områden som socialt arbete, vård och omsorg.
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| 3. |
- Austeng, Dordi, et al.
(författare)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 4. |
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| 5. |
- Blom, Johannes, et al.
(författare)
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A 9-year follow-up study of participants and nonparticipants in sigmoidoscopy screening : importance of self-selection
- 2008
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 17:5, s. 1163-1168
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Self-selection may compromise cost-effectiveness of screening programs. We hypothesized that nonparticipants have generally higher morbidity and mortality than participants. METHODS: A Swedish population-based random sample of 1,986 subjects ages 59 to 61 years was invited to sigmoidoscopy screening and followed up for 9 years by means of multiple record linkages to health and population registers. Gender-adjusted cancer incidence rate ratio (IRR) and overall and disease group-specific and mortality rate ratio (MRR) with 95% confidence intervals (95% CI) were estimated for nonparticipants relative to participants. Cancer and mortality rates were also estimated relative to the age-matched, gender-matched, and calendar period-matched Swedish population using standardized incidence ratios and standardized mortality ratios. RESULTS: Thirty-nine percent participated. The incidence of colorectal cancer (IRR, 2.2; 95% CI, 0.8-5.9), other gastrointestinal cancer (IRR, 2.7; 95% CI, 0.6-12.8), lung cancer (IRR, 2.2; 95% CI, 0.8-5.9), and smoking-related cancer overall (IRR, 1.4; 95% CI, 0.7-2.5) tended to be increased among nonparticipants relative to participants. Standardized incidence ratios for most of the studied cancers tended to be >1.0 among nonparticipants and <1.0 among participants. Mortality from all causes (MRR, 2.4; 95% CI, 1.7-3.4), neoplastic diseases (MRR, 1.9; 95% CI, 1.1-3.5), gastrointestinal cancer (MRR, 4.7; 95% CI, 1.1-20.7), and circulatory diseases (MRR, 2.3; 95% CI, 1.2-4.2) was significantly higher among nonparticipants than among participants. Standardized mortality ratio for the studied outcomes tended to be increased among nonparticipants and was generally decreased among participants. CONCLUSION: Individuals who might benefit most from screening are overrepresented among nonparticipants. This self-selection may attenuate the cost-effectiveness of screening programs on a population level.
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| 6. |
- Blom, Johannes, et al.
(författare)
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Toward understanding non participation in sigmoidoscopy screening for colorectal cancer
- 2008
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 122:7, s. 1618-1623
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the reasons for nonparticipation in cancer screening may give clues about how to improve compliance. However, limited cooperation has hampered research on nonparticipant profiles. We took advantage of Sweden's comprehensive demographic and health care registers to investigate characteristics of all participants and nonparticipants in a pilot program for colorectal cancer screening with sigmoidoscopy. A population-based sample of 1986 Swedish residents 59-61 years old was invited. Registers provided information on each individual's gender, country of birth, marital status, education, income, hospital contacts, place of residence, distance to screening center and cancer within the family. Odds ratios (ORs) with 95% confidence intervals (CIs), modeled with multivariable logistic regression, estimated the independent associations between each background factor and the propensity for nonparticipation after control for the effects of other factors. All statistical tests were 2-sided. Being male (OR = 1.27, 95% CI = 1.03-1.57, relative to female), unmarried or divorced (OR = 1.69, 95% CI = 1.23-2.30 and OR = 1.49, 95% CI = 1.14-1.95, respectively, relative to married) and having an income in the lowest tertile (OR = 1.68, 95% CI = 1.27-2.23, relative to highest tertile) was associated with increased nonparticipation. Living in the countryside or in small communities and having a documented family history of colorectal cancer was associated with better participation. Distance to the screening center did not significantly affect participation, nor did recent hospital care consumption or immigrant status. To increase compliance, invitations must appeal to men, unmarried or divorced people and people with low socioeconomic status.
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| 7. |
- Blomqvist, Lennart, 1947, et al.
(författare)
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Arachidonic acid-induced platelet aggregation and acetylsalicylic acid treatment during pregnancy in women with recurrent miscarriage, a post hoc study
- 2022
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Ingår i: Platelets. - : Informa UK Limited. - 0953-7104 .- 1369-1635. ; 33:2, s. 278-284
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Tidskriftsartikel (refereegranskat)abstract
- In this post hoc study, arachidonic acid (AA)-induced platelet aggregation during pregnancy with and without acetylsalicylic acid (ASA) treatment was studied in 323 women with unexplained recurrent first-trimester miscarriage and in 59 healthy women with normal pregnancies. All women had normal AA-induced platelet aggregation in the non-pregnant state. Women with recurrent miscarriage were treated with 75 mg ASA or placebo daily. AA-induced platelet aggregation was measured with multiple electrode impedance aggregometry and presented in units (U), where 1 U = 10 aggregation units x minutes. There were no significant differences in platelet aggregation between placebo-treated women with recurrent miscarriage and healthy women. The mean differences were -0.7 (95%CI; -7.0; 5.6) U in the non-pregnant state, 3.8 (95%CI; -4.6; 12.2) U during the late first trimester and 1.7 (95%CI; -6.7; 10.3) U and 4.1 (95%CI; -3.9; 12.0) U during the early and late third trimester, respectively. ASA reduced platelet aggregation by median -84.0% (Q1; Q3; -89.8; -76.3), -79.9% (-84.7; -69.2) and -75.7% (-83.5; -49.5), respectively, during pregnancy. The degree of inhibition by ASA decreased during the third trimester (p < .0001). There were two (1.9%) complete non-responders to ASA and 32.1% with a partial response. The rate of subsequent miscarriage was not affected by ASA, which did not seem to influence the rate of early miscarriage if treatment was initiated when a viable pregnancy was detectable by ultrasound.
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| 8. |
- Claesson, Ing-Marie, et al.
(författare)
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Consumer satisfaction with a weight-gain intervention programme for obese pregnant women
- 2008
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Ingår i: Midwifery. - : Elsevier. - 0266-6138 .- 1532-3099. ; 24:2, s. 163-167
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Tidskriftsartikel (refereegranskat)abstract
- Objective: to investigate women's attitudes and satisfaction with a weight-gain intervention programme during pregnancy.Design: exploratory, descriptive study. Data were collected via interviews.Setting: University hospital.Participants: 56 obese pregnant women who attended antenatal care at the University Hospital of Linkoping's obstetrical department and took part in an intervention programme aimed at reducing weight gain during pregnancy, between November 2003 and August 2004.Findings: the interviews comprised several questions concerning attitudes and opinions of the programme. Most of the women expressed positive experiences with the treatment and would attend the programme if they became pregnant again. Most of the women stated that they had changed their eating and exercise habits during pregnancy, and almost all of them had continued with these new habits. Even though the weight gain goal of a maximum 6.9 kg was reached by less than half of the participants, most of the women were satisfied with their weight gain. A total of 71.4% of the women participated in aqua aerobics classes. They stated that they were most satisfied with this form of exercise, and that it also was a good social experience.Key conclusions and implications for practice: a pregnant woman herself must be actively involved in setting her own goals to prevent excessive weight gain during pregnancy. Considerable effort and support must be placed on discussing strategies, pitfalls and risks. In order for the woman to maintain the change in attitude and habits, she must probably be given continuous feedback and reinforcement over the long term.
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| 9. |
- Claesson, Ing-Marie, 1953-, et al.
(författare)
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Weight after childbirth : A 2-year follow-up of obese women in a weight-gain restriction program
- 2011
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Informa Healthcare. - 0001-6349 .- 1600-0412. ; 90:1, s. 103-110
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objective: To investigate the effects of a weight gain restriction program on weight development or weight maintenance two years after childbirth. Methods: The intervention group consisted of 155 obese pregnant women who participated in a weight gain restriction program with weekly support duringpregnancy. The control group consisted of 193 obese pregnant women. Follow-up weight measurements were done at 12 and 24 months postpartum. Results: The mean value of weight change in the intervention group was -2.2 kg compared to + 0.4 kg in the control group from early pregnancy to the follow-up 12 months after childbirth (p = .046). A greater percentage of women in the intervention group showed a weight loss 24 months after delivery than did women in the control group at that same time (p = .034). Women in the intervention group who gained less than 7 kg during pregnancy had a significantly lower weight than the controls at the 24 months follow-up (p = .018). Conclusion: An intervention program with weekly motivational support visits during pregnancy and every 6 months after childbirth seems to have an impact on weight gain up to 24 months after childbirth for those women in the intervention group who succeeded in restricting their gestational weight gain to less than 7 kg.
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| 10. |
- Claesson, Ing-Marie, et al.
(författare)
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Weight gain restriction during pregnancy is safe for both the mother and neonate
- 2009
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : John Wiley & Sons. - 0001-6349 .- 1600-0412. ; 88:10, s. 1158-1162
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to investigate whether pregnancy, delivery, and neonatal outcome among obese pregnant women who took part in an intervention study for weight restriction differed from a group of obese pregnant women attending regular antenatal care. The intervention group consisted of 155 obese pregnant women and 193 obese pregnant women who formed a control group. We found that a weight gain restriction of less than 7 kg during pregnancy is safe for both the mother and the neonate.
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| 11. |
- Claesson, Ing-Marie, 1953-, et al.
(författare)
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Weight gain restriction for obese pregnant women : A case-control intervention study
- 2008
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Ingår i: British Journal of Obstetrics and Gynecology. - : Wiley. - 1470-0328 .- 1471-0528. ; 115:1, s. 44-50
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To minimise obese women's total weight gain during pregnancy to less than 7 kg and to investigate the delivery and neonatal outcome. Design: A prospective case-control intervention study. Setting: Antenatal care clinics in the southeast region of Sweden. Population: One hundred fifty-five pregnant women in an index group and one hundred ninety-three women in a control group. Methods: An intervention programme with weekly motivational talks and aqua aerobic classes for obese pregnant women. Main outcome measures: Weight gain in kilograms, delivery and neonatal outcome. Results: The index group had a significantly lower weight gain during pregnancy compared with the control group (P < 0.001). The women in the index group weighed less at the postnatal check-up compared with the weight registered in early pregnancy (P < 0.001). The percentage of women in the index group who gained less than 7 kg was greater than that of women in the control group who gained less than 7 kg (P = 0.003). The percentage of nulliparous women in this group was greater than that in the control group (P = 0.018). In addition, the women in the index group had a significantly lower body mass index at the postnatal check-up, compared with the control group (P < 0.001). There were no differences between the index group and the control group regarding birthweight, gestational age and mode of delivery. Conclusion: The intervention programme was effective in controlling weight gain during pregnancy and did not affect delivery or neonatal outcome.
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| 12. |
- Fellman, Vineta, et al.
(författare)
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One-year survival of extremely preterm infants after active perinatal care in Sweden.
- 2009
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Ingår i: JAMA : the journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 301:21, s. 2225-33
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Tidskriftsartikel (refereegranskat)abstract
- Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling.
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| 13. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 14. |
- Grothérus, Annika, 1972-, et al.
(författare)
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Formative Scaffolding : how to alter the level and strength of self-efficacy and foster self-regulation in a mathematics test situation
- 2018
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Ingår i: Educational action research. - : Taylor & Francis Group. - 0965-0792 .- 1747-5074. ; 27:5, s. 667-690
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study is to advocate the use of a participatory action research programme, the Formative Scaffolding Programme (FSP), in mathematics. The FSP’s main structure is presented as well as an implementation of a class intervention, with the aim of exploring the FSP test cycle’s virtues in a social science class in a Swedish upper-secondary school. The motivations for the FSP’s development were to enhance students’ awareness of their mathematical proficiency, alter the level and strength of their self-efficacy, foster self-regulated learning (SRL), reduce and prevent mathematics-related anxiety, and visualise the learning process in mathematics. The primary findings of the study were there was a resemblance between the FSP setting and SRL phases, and that participation in the test cycle altered the level and strength of students’ self-efficacy and fostered self-regulation in a mathematics test situation. The benefits of working in a formative scaffolding manner indicate that it is worth implementing the FSP on a larger scale. The study is an example of how students can engage in transforming classroom practice and be radical agents of change.
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| 15. |
- Hardell, Christian, et al.
(författare)
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A relational database for general mechanical systems
- 1995
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Ingår i: Computational Dynamics in Multibody Systems. - Dordrecht : Encyclopedia of Global Archaeology/Springer Verlag. - 792333047 ; , s. 49-59
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Konferensbidrag (refereegranskat)abstract
- This paper provides a specification of a relational data base structure for mechanical systems. Through the example provided, a robot gripping device, it is demonstrated how the initial development of the data-base structure has successfully led to an implementation in a practical software environment. The data base is accessible to multiple engineering application programs and supports a flexible environment for the continuing development of new applications
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| 16. |
- Hermansson, Cecilia, et al.
(författare)
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Reduced expression of NLRP3 and MEFV in human ischemic heart tissue.
- 2013
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Ingår i: Biochemical and biophysical research communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 430:1, s. 425-428
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Tidskriftsartikel (refereegranskat)abstract
- The innate immune system and, in particular, activation of the multi-protein complex known as the inflammasome complex are involved in ischemic injury in myocardial cells. The nucleotide-binding leucine-rich repeat-containing pyrin receptor 3 (NLRP3) inflammasome has been linked to inflammation and NLRP3 is especially important for increased inflammation in atherosclerosis, which may lead to myocardial infarction. Here we investigated how inflammasome molecules are affected in human ischemic heart tissue. Surprisingly the important member of the inflammasome complex, NLRP3, displayed markedly decreased levels in human ischemic heart tissue compared with non ischemic control heart tissue. However, subsequent gene analysis revealed mutations in NLRP3 in human ischemic heart tissues but not in non-ischemic control tissue. Gene polymorphisms in the NLRP3 inflammasome have been shown to be associated with increased IL-1β and IL-18 production and severe inflammation. The autoinflammatory disorder familial Mediterranean fever (FMF) is associated with decreased expression of the Mediterranean fever gene (MEFV) and increased inflammation. We also observed reduced expression of MEFV in ischemic versus non-ischemic heart tissue. Further analyses showed a mutation in MEFV in human ischemic heart tissue but not in non-ischemic control tissue. Our data show that defects in the inflammasome and associated proteins may be involved in promoting ischemic heart disease.
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| 17. |
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| 18. |
- Jeppsson, Annika, 1958-
(författare)
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The significance of placental and placental-like alkaline phosphatases in tumor biology and their potential use in clinical practice
- 1984
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Placental alkaline phosphatase (PLAP) is a membrane bound enzyme normally synthesized by the syncytiotrophoblasts in the human placenta. Recent studies have indicated that trace amounts of placental-like alkaline phosphatases also are present in several normal organs like testes and endocervix. PLAP and PLAP-1ike enzymes are furthermore synthesized by some tumors and can be detected in sera of approximately 12 % of patients with any type of cancer, more often in patients with genital tumors. This synthesis has been considered to be ectopic.PLAP is known to be electrophoretically highly polymorphic. Both poly- and monoclonal antibodies were used to study this enzyme. One of the monoclonal antibodies was able to discriminate between different phenotypes of PLAP and thus immunochemical approaches to elucidate enzyme polymorphism were established.To evaluate the potential clinical use of PLAP as a tumor marker serum levels of the enzyme were measured by a radioimmunoassay in 100 patients with the testicular tumor seminoma. Elevated levels of PLAP were found in 43 % of the patients with primary tumors and in 75 % of the patients with recurrent or metastatic disease. After successful treatment of seminoma the PLAP levels decreased. This indicates that measuring PLAP give useful information during follow up of treatment of seminomas.The content of PLAP-like enzymes in seminoma tumors was determined in 13 typical seminomas. The levels, of enzyme found in the tumor tissue ranged from 870-13 404 ng/g wet weight, which should be compared to around 100 ng/g in normal testes. Analysis using monoclonal antibodies and enzyme inhibitors showed the PLAP-like enzymes present in seminomas to be similar to the enzymes in normal testes. This suggests that the increased expression of PLAP-like enzymes in seminomas results from an enhanced eutopic expression of enzymes found in normal testis.A sensitive catalytic assay was used to quantify enzyme levels in sera from women with malignant gynaecological tumors. In the group of patients with cervical carcinoma 68 % had values exceeding the normal limit. For patients with ovarian cancer and carcinoma of the breast the percentages were 35 and 23 respectively.Monoclonal and polyclonal antibodies against PLAP were evaluated for tumor immunolocalization of human PLAP-producing tumors in nude mice.The antibodies were labeled with "125j and injected into mice with tumors. The distribution of 25j_an-ti-PLAP in various tissues showed that the labeled antibodies were enriched in the tumors, with a mean concentration ratio of 7. This indicates that there is a potential use of PLAP in localizing tumors in humans.
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| 19. |
- Jeppsson-Grassman, Eva, et al.
(författare)
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“A home away from home” : The role of the Church of Sweden Abroad for Swedish migrants
- 2013
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Ingår i: New Religiosity in Migration. ; , s. 38-41
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Konferensbidrag (refereegranskat)abstract
- According to some studies, Sweden is one of the most secularized countries in the world. with low church attendance. For most Swedes, their contact with the church is limited to traditional rites. How are we then to understand that quite a few Swedes seem to act much like immigrant groups from less secularized nations, by turning to the ethnic church and to religious practices while moving – fully or part time – to foreign countries?The aim of the presentation is to discuss this question, based on results from a project in which the role of the Church of Sweden Abroad has been explored. The Church of Sweden has a long traditions of creating parishes abroad, mainly in the larger European cities and in connection with harbors, as Seaman`s Churches. Since some decades, however, the Church has started to follow the streams of tourists and elderly migrants and parishes have been established, mainly in Southern Europe and, lately in Asian countries.The presentation will be based on a project consisting of three studies: 1) A qualitative case study, 2) A mapping of the web sites of all 45 parishes, and 3) An internet-based survey of all parishes. An interesting pattern turned out to be that many church visitors who initially seemed to be attracted by the (Swedish) “home away from home” that the parish offered through e.g. “Swedish coffee”, eventually began to participate regularly in the church services, even in Holy Communion.
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| 20. |
- Jeppsson-Grassman, Eva, 1944-, et al.
(författare)
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A long life with a particular signature : life course and ageing for people with disabilities
- 2012
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Ingår i: Journal of gerontological social work. - : Routledge. - 0163-4372 .- 1540-4048. ; 55:2, s. 95-111
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Tidskriftsartikel (refereegranskat)abstract
- What does it mean to live a long life and grow old with disabilities? Or to be an aging parent and still be a caregiver to a disabled adult child? These are questions discussed in this article, the aim of which is to show how a life course perspective adds insight to the lived experience of disability and ageing of adults with disabilities. It is argued that the time concept is fundamental to the understanding of the lives of disabled people. Results are presented which challenge established knowledge regarding disability policies, autonomy, body, biographical disruption and prerequisites of active aging.
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| 21. |
- Jeppsson-Grassman, Eva, 1944-, et al.
(författare)
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Att reflektera över forskningsmetoder : en bakgrund
- 2015
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Ingår i: Att studera funktionshinder och åldrande. - Norrköping : Nationella institutet för forskning och äldre och åldrande (NISAL), Linköpings unversitet. - 9789175191591 ; , s. 15-27
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 22. |
- Jeppsson Grassman, Eva, et al.
(författare)
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Ett långt liv med särskilda förtecken : Livslopp och åldrande hos människor med funktionsnedsättningar
- 2011
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Ingår i: Socialvetenskaplig tidskrift. - 1104-1420 .- 2003-5624. ; 18:2, s. 107-125
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Vad innebär det att åldras med funktionsnedsättningar som man fått redan i tidig ålder eller som yngre vuxen? På vilket sätt formar funktionshinder livet över tid? Och hur är det att vara en till åren kommen förälder och fortfarande vara central som hjälpgivare till ett vuxet, funktionshindrat barn? Vilken betydelse har epoken och reformerna? I artikeln diskuteras dessa frågor med utgångspunkt i ett brett upplagt forskningsprojekt ”Funktionshinder, livslopp och åldrande”
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| 23. |
- Jeppsson Grassman, Eva, 1944-, et al.
(författare)
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Family as failure? The role of informal help-givers to disabled people in Sweden.
- 2009
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Ingår i: Scandinavian Journal of Disability Research. - : Stockholm University Press. - 1501-7419 .- 1745-3011. ; 11:1, s. 35-49
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Tidskriftsartikel (refereegranskat)abstract
- Based on a survey mapping all unpaid help and care work in the county of Stockholm, this article focuses on the informal help and care carried out for long-term ill and/or disabled people aged 64 or younger. The findings indicate that these forms of support are common and that the informal help-givers work many hours every month. Yet the impact of this work is quite invisible in texts on disability policy and there is a void of research addressing this issue. This article argues that, in spite of welfare state arrangements and reforms, families play a crucial role in providing resources, notably help and care for disabled family members. Their invisibility is interpreted as an expression of the fact that the care concept has become politically incorrect. In the light of modern disability policies, with its ideals of autonomy and empowerment, help and care provided by families to adults aged 64 or younger stand out as a dilemma and a contradiction. Making help and care provided by families invisible can be interpreted as one way of solving this contradiction.
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| 24. |
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| 25. |
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| 26. |
- Jeppsson-Grassman, Eva, 1944-, et al.
(författare)
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Som ett andra hem? : Svenska utlandskyrkan i en tid av globalisering och äldremigration
- 2012. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Vad gör en utlandsförsamling och vilken är dess roll och betydelse i en tid av ökande globalisering? Det är frågor som diskuteras i denna rapport. Vi lever i värld med ökat resande och förändrade migrationsmönster. Det blir allt vanligare också att äldre människor, till exempel nordeuropeiska pensionärer, flyttar till varmare länder permanent eller tillfälligt. Människor blir alltmer gränslösa. Det innebär dock inte att deras behov av sammanhang, relationer och omsorg upphör. Det har varit en utgångspunkt för det projekt om utlandskyrkan på vars resultat den här rapporten bygger.De svenska utlandsförsamlingarna finns utspridda i olika delar av världen. De skiljer sig åt i storlek och till sin karaktär, liksom i viss utsträckning när det gäller typen av besökare. Ändå har de stora likheter och många gemensamma drag visar resultaten. Det svenska språket står i centrum, det är svenskarna som är målgrupperna, och för dem fungerar utlandskyrkan som en tillflyktsort och som en hemvist i ett främmande land. Bilden av församlingarnas religiösa roll framstår som intressant men mångtydig och ganska motsägelsefull.
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| 27. |
- Jeppsson-Grassman, Eva, 1944-, et al.
(författare)
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Som ett andra hem? Svenska utlandskyrkan i en tid av globalisering och äldremigration
- 2013. - 2
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Vad gör en utlandsförsamling och vilken är dess roll och betydelse i en tid av ökande globalisering? Det är frågor som diskuteras i denna rapport. Vi lever i värld med ökat resande och förändrade migrationsmönster. Det blir allt vanligare också att äldre människor, till exempel nordeuropeiska pensionärer, flyttar till varmare länder permanent eller tillfälligt. Människor blir alltmer gränslösa. Det innebär dock inte att deras behov av sammanhang, relationer och omsorg upphör. Det har varit en utgångspunkt för det projekt om utlandskyrkan på vars resultat den här rapporten bygger.De svenska utlandsförsamlingarna finns utspridda i olika delar av världen. De skiljer sig åt i storlek och till sin karaktär, liksom i viss utsträckning när det gäller typen av besökare. Ändå har de stora likheter och många gemensamma drag visar resultaten. Det svenska språket står i centrum, det är svenskarna som är målgrupperna, och för dem fungerar utlandskyrkan som en tillflyktsort och som en hemvist i ett främmande land. Bilden av församlingarnas religiösa roll framstår som intressant men mångtydig och ganska motsägelsefull.
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| 28. |
- Jeppsson, Johan, et al.
(författare)
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Inverse Saltykov analysis for particle-size distributions and their time evolution
- 2011
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Ingår i: Acta Materialia. - : Elsevier BV. - 1359-6454 .- 1873-2453. ; 59:3, s. 874-882
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Tidskriftsartikel (refereegranskat)abstract
- In this work a new method for transforming 2-D to 3-D size distributions is proposed. A representation of the 2-D size distributions is constructed from the data of measured radii with a statistical method called the kernel density estimator. The method yields a smooth density estimation that is more accurate than the classic histogram. The 3-D distribution is optimized from the 2-D density estimate in an iterative manner. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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| 29. |
- Klevstig, Martina, et al.
(författare)
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Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart
- 2016
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Ingår i: Journal of Molecular and Cellular Cardiology. - : Elsevier BV. - 0022-2828 .- 1095-8584. ; 93, s. 69-72
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Tidskriftsartikel (refereegranskat)abstract
- Ceramide accumulation is known to accompany acute myocardial ischemia, but its role in the pathogenesis of ischemic heart disease is unclear. In this study, we aimed to determine how ceramides accumulate in the ischemic heart and to determine if cardiac function following ischemia can be improved by reducing ceramide accumulation. To investigate the association between ceramide accumulation and heart function, we analyzed myocardial left ventricle biopsies from subjects with chronic ischemia and found that ceramide levels were higher in biopsies from subjects with reduced heart function. Ceramides are produced by either de novo synthesis or hydrolysis of sphingomyelin catalyzed by acid and/or neutral sphingomyelinase. We used cultured HL-1 cardiomyocytes to investigate these pathways and showed that acid sphingomyelinase activity rather than neutral sphingomyelinase activity or de novo sphingolipid synthesis was important for hypoxia-induced ceramide accumulation. We also used mice with a partial deficiency in acid sphingomyelinase (Smpd1(+/-) mice) to investigate if limiting ceramide accumulation under ischemic conditions would have a beneficial effect on heart function and survival. Although we showed that cardiac ceramide accumulation was reduced in Smpd1(+/-) mice 24 h after an induced myocardial infarction, this reduction was not accompanied by an improvement in heart function or survival. Our findings show that accumulation of cardiac ceramides in the post-ischemic heart is mediated by acid sphingomyelinase. However, targeting ceramide accumulation in the ischemic heart may not be a beneficial treatment strategy.
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| 30. |
- Lachonius, Maria, 1962, et al.
(författare)
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Patients' motivation to undergo transcatheter aortic valve replacement. A phenomenological hermeneutic study.
- 2023
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Ingår i: International journal of older people nursing. - : Wiley. - 1748-3743 .- 1748-3735. ; 18:1
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Tidskriftsartikel (refereegranskat)abstract
- Aortic stenosis is the most common valvular disease, and its prevalence is increasing due to the ageing population. Transcatheter aortic valve replacement (TAVR) is the recommended method when treating frail, older patients. Knowledge of what motivates older patients to undergo TAVR is important, in order to meet patients' expectations.The study aimed to explore the meaning of older patients' motivation to undergo TAVR.The design was a qualitative study, analysed using a phenomenological hermeneutic approach. In-depth, semi-structured interviews with open-ended questions were conducted. Participants were selected from a specialist cardiology clinic in Sweden. Eighteen patients, six women and twelve men, aged 66-92, were recruited.The analysis showed that patients who had agreed to undergo TAVR were deeply affected by their body's failure. Before the TAVR procedure, the participants were limited in their daily activities and experienced that their life was on hold. They experienced that they were barely existing. They were aware of their life-threatening condition and were forced to confront death. Yet despite an advanced age, they still had considerable zest for life. It was very important to them to remain independent in everyday life, and fear of becoming dependent had a strong impact on their motivations for undergoing TAVR.Older patients' motivations to undergo TAVR are strongly influenced by their fear of being dependent on others and their zest for life. Health care professionals need to support these patients in setting realistic and personalised goals.Person-centered care actions could facilitate patients' involvement in the decision about TAVR and strenghten patients' beliefs in their own capabilities, before and after TAVR.
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| 31. |
- Llona-Minguez, Sabin, et al.
(författare)
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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
- 2016
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 59:3, s. 1140-1148
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Tidskriftsartikel (refereegranskat)abstract
- The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated with cancer cell sternness. Here we report on the development of the first potent and selective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogues in leukemia cells. Boronate 30 displays a promising in vitro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeability and CYP inhibition, deeming it a suitable compound for in vivo studies.
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| 32. |
- Lundqvist, Annika, 1969, et al.
(författare)
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The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation
- 2016
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 11:8
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Tidskriftsartikel (refereegranskat)abstract
- Ischemic heart disease is a major cause of death and morbidity and the search for novel therapeutic targets is still required. We have previously shown that the enzyme arachidonate 15 lipoxygenase (ALOX15), which catalyzes the conversion of arachidonic acid to 15-hydroxy eicosatetraenoic acid (15-HETE), is highly expressed in ischemic heart tissue, but its role in the pathogenesis of ischemic heart disease is unclear. Here we showed that expression of ALOX15, but not ALOX12 or ALOX15B, was increased in ischemic versus non-ischemic human heart biopsy samples. A similar ALOX expression pattern was found in hypoxic human cardiomyocytes and cardiac endothelial cells. We also showed that levels of 15-HETE were significantly higher in ischemic versus non-ischemic human heart biopsy samples and showed a tendency to increase in serum from the patients with ischemic heart disease. Moreover, hypoxia increased the production of 15-HETE levels from human cardiomyocytes and cardiac endothelial cells. The hypoxia-induced increase in 15-HETE levels from human cardiomyocytes was inhibited by the ALOX15 inhibitor baicalein. Finally, by using intrinsic rotational thromboelastometry, we showed that human whole blood clotted faster in the presence of 15-HETE. In summary, we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.
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| 33. |
- Magnusson, Lisa U., 1975, et al.
(författare)
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High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue
- 2012
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Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 424:2, s. 327-330
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Tidskriftsartikel (refereegranskat)abstract
- A common feature of the ischemic heart and atherosclerotic plaques is the presence of hypoxia (insufficient levels of oxygen in the tissue). Hypoxia has pronounced effects on almost every aspect of cell physiology, and the nuclear transcription factor hypoxia inducible factor-1 alpha or (HIF-1 alpha) regulates adaptive responses to low concentrations of oxygen in mammalian cells. In our recent work, we observed that hypoxia increases the proinflammatory enzyme arachidonate 15-lipoxygenase (ALOX15B) in human carotid plaques. ALOX15 has recently been shown to be present in the human myocardium, but the effect of ischemia on its expression has not been investigated. Here we test the hypothesis that ischemia of the heart leads to increased expression of ALOX15, and found an almost 2-fold increase in HIF-1 alpha mRNA expression and a 17-fold upregulation of ALOX15 mRNA expression in the ischemic heart biopsies from patients undergoing coronary bypass surgery compared with non ischemic heart tissue. To investigate the effect of low oxygen concentration on ALOX15 we incubated human vascular muscle cells in hypoxia and showed that expression of ALOX15 increased 22-fold compared with cells incubated in normoxic conditions. We also observed increased mRNA levels of proinflammatory markers in ischemic heart tissue compared with non-ischemic controls. In summary, we demonstrate increased ALOX15 in human ischemic heart biopsies. Furthermore we demonstrate that hypoxia increases ALOX15 in human muscle cells. Our results yield important insights into the underlying association between hypoxia and inflammation in the human ischemic heart disease. (C) 2012 Elsevier Inc. All rights reserved.
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| 34. |
- Mannesson, Karin, et al.
(författare)
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Carbide grain growth in cemented carbides
- 2011
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Ingår i: Acta Materialia. - : Elsevier BV. - 1359-6454 .- 1873-2453. ; 59:5, s. 1912-1923
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Tidskriftsartikel (refereegranskat)abstract
- Abnormal grain growth is often observed in cemented carbides during sintering, but cannot be understood in terms of the classical LSW theory. In this work the grain growth behavior during sintering at 1430 °C is studied both experimentally and by means of computer simulations. A model based on several processes—2-D nucleation of growth ledges, mass transfer across the interface and long-range diffusion coupled in series—is formulated and the equations are solved numerically. Both computer simulations and experimental studies reveal that the grain growth behavior is strongly influenced by the initial size distribution.
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| 35. |
- Nielsen, Susanne, 1969, et al.
(författare)
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Social Factors, Sex, and Mortality Risk After Coronary Artery Bypass Grafting: A Population-Based Cohort Study
- 2019
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 8:6
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Tidskriftsartikel (refereegranskat)abstract
- Background Little is known of the impact of social factors on mortality after coronary artery bypass grafting ( CABG ). We explored sex- and age-specific associations between mortality risk after CABG and marital status, income, and education. Methods and Results This population-based register study included 110742 CABG patients (21.3% women) from the SWEDEHEART registry (Swedish Web-system for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated According to Recommended Therapies) operated 1992 to 2015. Cox regression models were used to study the relation between social factors and all-cause mortality. Never having been married compared with being married/cohabiting was associated with a higher risk in women than in men (hazard ratio 1.32, 95% CI 1.20-1.44) versus 1.17 (1.13-1.22), P=0.030 between sex. The lowest income quintile, compared with the highest, was associated with higher risk in men than in women (hazard ratio 1.44 [1.38-1.51] versus 1.25 [1.14-1.38], P=0.0036). Lowest education level was associated with higher risk without sex difference (hazard ratio 1.15 [1.11-1.19] versus 1.25 [1.16-1.35], P=0.75). For unmarried women aged 60 years at surgery with low income and low education, mortality 10years after surgery was 18%, compared with 11% in married women with high income and higher education level. The median life expectancy was 4.8years shorter. Corresponding figures for 60-year-old men were 21% versus 12% mortality risk at 10 years and 5.0years shorter life expectancy. Conclusions There are strong associations between social factors and mortality risk after CABG in both men and women. These results emphasize the importance of developing and implementing secondary prevention strategies for CABG patients with disadvantages in social factors.
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| 36. |
- Nielsen, Susanne, 1969, et al.
(författare)
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Trends in mortality risks among 94,328 patients surviving 30 days after a first isolated coronary artery bypass graft procedure from 1987 to 2006: A population-based study
- 2017
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Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 244, s. 316-321
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Tidskriftsartikel (refereegranskat)abstract
- Background: Updated knowledge about survival after coronary artery bypass graft (CABG) surgery is needed. We examined 20-year trends in 4-year survival after a first isolated CABG procedure, compared with that of the general population. Methods: We identified 94,328 patients surviving 30 days after a first isolated CABG 1987-2006 from the Swedish Inpatient Register. Results: Crude annual mortality rates remained stable at approximately 1% in patients aged 18-54 years and at approximately 2% in those aged >= 55 years. After adjustment for comorbidities, 4-year survival in men aged 18-54 and >= 55 years improved by 37% (HR: 0.63, 95% CI, 0.46-0.88) and 31% (HR: 0.69, 95% CI, 0.63-0.76), respectively, (1987-1991 vs. 2002-2006). The corresponding estimate for women aged >= 55 years was 38% (HR: 0.62, 95% CI, 0.52-0.75), with no significant change in survival in women aged b55 years (HR: 1.02, 95% CI, 0.52-2.03). Men and women aged b55 years had higher mortality than the general population, with standardized mortality ratios (SMR) of 1.76 (95% CI, 1.35-2.22) in men and 4.49 (95% CI, 2.74-6.68) in women during the last period (2002-2006). In contrast, patients aged >= 55 years had better survival with a SMR of 0.74 (95% CI, 0.70-0.78) in men and 0.82 (95% CI, 0.74-0.91) in women during 2002-2006. Conclusion: During 1987-2006, there was a significant improvement in survival after CABG for all categories, except in women aged < 55 years. Men and women aged >= 55 years who survived the first 30 days after CABG had a lower mortality risk than the general population.
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| 37. |
- Rotter Sopasakis, Victoria, 1972, et al.
(författare)
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Toll-like receptor-mediated inflammation markers are strongly induced in heart tissue in patients with cardiac disease under both ischemic and non-ischemic conditions.
- 2019
-
Ingår i: International journal of cardiology. - : Elsevier BV. - 1874-1754 .- 0167-5273. ; 293, s. 238-247
-
Tidskriftsartikel (refereegranskat)abstract
- A sustained low grade inflammatory state is a recognized feature of various diseases, including cardiovascular disease. This state of chronic inflammation involves activation of Toll-like receptor (TLR) signaling. However, little is known regarding the genetic profile of TLR components in cardiac tissue from patients with cardiac disease.In this study we investigated the genetic profile of 84 TLR markers in a unique set of cardiac tissue from patients that had undergone either coronary artery bypass grafting (CABG) or aortic valve replacement (AVR). In addition, we compared the gene data from the cardiac tissue with the same gene profile in blood as well as circulating cytokines to elucidate possible targets in blood that could be used to estimate the inflammatory state of the heart in cardiac disease.We found a marked upregulation of TLR-induced inflammation in cardiac tissue from both patient groups compared to healthy controls. The inflammation appeared to be primarily mediated through TLR1, 3, 7, 8 and 10, resulting in a marked induction of mediators of the innate immune response. Furthermore, the gene expression data in combination with unbiased multivariate analysis suggested a difference in inflammatory response in ischemic cardiac tissue compared to non-ischemic cardiac tissue. Serum levels of IL-13 were significantly elevated in both CABG and AVR patients compared to controls, whereas other cytokines did not appear to coincide with cardiac TLR-induced inflammation.We propose that cardiac disease in humans may be mediated by local cardiac TLR signaling under both ischemic and non-ischemic conditions.
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| 38. |
- Sandstedt, Joakim, et al.
(författare)
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Human cardiac fibroblasts isolated from patients with severe heart failure are immune-competent cells mediating an inflammatory response.
- 2019
-
Ingår i: Cytokine. - : Elsevier BV. - 1096-0023 .- 1043-4666. ; 113, s. 319-325
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Tidskriftsartikel (refereegranskat)abstract
- This study was aimed to elucidate the immunoregulatory properties of human cardiac fibroblasts cultured under pro-inflammatory and hypoxic conditions. Human heart tissue for isolating cardiac cells is generally hard to obtain, particularly from all four chambers of the same heart. Since different parts of the heart have different functions and therefore may have different immunoregulatory properties, ability to analyse cells from all chambers allows for a unique and comprehensive investigation. Cells were isolated from all four chambers of the heart from patients undergoing cardiac transplantation surgery due to severe chronic heart failure (CHF) (n=6). Cells isolated from one donor heart, were used for comparison with the experimental group. Primary cultured human cardiac fibroblasts were treated with Lipopolysaccharide (LPS) to induce an inflammatory response. Cells were also subjected to hypoxia. To determine immunoregulatory properties of the cells, cytokine and chemokine profiles were determined using multiplex ELISA. RESULTS: On average, the fibroblasts population constituted approximately 90% of the expanded non-myocytes. Levels of cytokines and chemokines were markedly increased in human cardiac fibroblasts cultured under inflammatory conditions, with a similar response in fibroblasts from all compartments of the heart. Unexpectedly, hypoxia did not further augment cytokine and chemokine secretion. In conclusion, human cardiac fibroblasts are a robust source of pro-inflammatory mediators in the failing heart, independent of hypoxia, and might play a critical role in inflammation associated with the pathogenesis of CHF.
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| 39. |
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| 40. |
- Taghizadeh Larsson, Annika, 1961-
(författare)
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Att åldras med funktionshinder : Betydelser av socialt och kronologiskt åldrande för människor som under lång tid levt med fysiska funktionsnedsättningar
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Ålderns och åldrandets betydelser för människor som under lång tid har levt med fysiska funktionsnedsättningar har hittills fått begränsad uppmärksamhet såväl i forskning som i andra sammanhang. Samtidigt pekar såväl åldersgränser i det offentliga stödsystemet som tidigare forskning mot att ålder och åldrande kan få speciella innebörder för människor som lever med funktionshinder. Syftet med den här avhandlingen är att tolka innebörder av åldersnormer och upplevd ålder för människor som i dagens Sverige befinner sig i de kronologiska åldrarna kring 65 med fysiska funktionsnedsättningar som funnits med under minst 30 år. Med åldersnormer avses ”enhetliga uppfattningar om de ’typiska’ åldrar då man innehar vissa roller under livsloppet”. Subjektiv ålder syftar på ”hur gammal man känner sig”. Åldrarna kring 65 har valt därför att det är en del av livsloppet då ålder, åldrande och åldersnormer kan förväntas få särskilt stor betydelse.En intervjustudie med 20 personer i åldrarna 56-72 har genomförts. Planeringen, genomförandet och analysen av intervjuerna har utgått från ett livsloppsperspektiv.Tolkningen av de intervjuades utsagor visar bland annat hur människor kan anamma ”äldrenormer” som ofta beskrivs som negativa i andra sammanhang på ett sätt som resulterar i något för individen positivt. Till skillnad från befintliga teorier om hälso- och funktionstillståndets betydelse för människors subjektiva ålder pekar studien också mot att det kan finnas en rad olika möjligheter att känna sig ung eller ”inte gammal” med funktionsnedsättningar och sjukdomar. Mot bakgrund av intervjupersonernas beskrivningar av sina dagliga liv framstår det därtill inte som orimligt att en ålderspensionär med omfattande funktionsnedsättningar med hjälp av ett individuellt anpassat stöd och hjälpmedel kan tillägna sig ett modernt och fritidsaktivt pensionärsideal på ett sätt som får som konsekvens att hon utformar sitt liv på ett ”tredje-ålder-likt” sätt. Ålder och åldrande framträder emellertid inte som betydelsefullt för alla aspekter av de intervjuades liv med funktionshinder. Särskilt inte för hur vissa förändringar av det egna funktionstillståndet upplevs.
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| 41. |
- Taghizadeh Larsson, Annika, 1961-, et al.
(författare)
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Behind the youtful facade : The Church of Sweden Abroad and its older visitiors and volunteers
- 2013
-
Konferensbidrag (refereegranskat)abstract
- The Swedish Church has local parishes in around 45 places abroad. Their mission is to provide community and support for Swedes who stay in foreign countries permanently, or for long or short periods. This presentation will present and discuss results from a research project exploring the Church of Sweden Abroad, with particular focus on migration, ageing and the last phases of life. The project consisted of a qualitative case study, a mapping of the websites of all 45 parishes abroad, and an internet-based survey of all parishes. The case study and the survey highlight the important role that older Swedes play in the parishes abroad. However, while people above the age of 65 in practice seem to “carry” many of the parishes̕ activities – and also seem to be “carried” by the parishes in terms of receiving support – this age category is virtually invisible in the photographs and texts on the websites. This paradox will be discussed in relation to the phenomenon of ageism and by looking at the marketing of the Church of Sweden Abroad as an expression of the youth-obsessed culture that is today so prominent in many contexts all over the world.
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| 42. |
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| 43. |
- Taghizadeh Larsson, Annika, 1961-, et al.
(författare)
-
Behind the Youthful Facade : The Church of Sweden Abroad and Its Older Visitors and Volunteers
- 2014
-
Ingår i: Journal of Religion, Spirituality & Aging. - : Routledge. - 1552-8030 .- 1552-8049. ; 26:4, s. 340-356
-
Tidskriftsartikel (refereegranskat)abstract
- This article addresses the role of the Church of Sweden Abroad, with its 45 parishes in foreign countries, for older Swedes who live or stay abroad, permanently or for long or short periods. The article is based on a research project comprising three studies: a qualitative study, an analysis of websites and information material, and an Internet-based survey. The results highlight the important role played by the parishes for older visitors, in terms of providing community, support, and religious services. However, people above the age of 65 were virtually invisible on the church websites and in other information material. This paradox is discussed and the concept of ageism is used in the analysis.
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| 44. |
- Taghizadeh Larsson, Annika, et al.
(författare)
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Bodily changes among people living with physical impairments and chronic illnesses : biographical disruption or normal illness?
- 2012
-
Ingår i: Sociology of Health and Illness. - : Wiley-Blackwell. - 0141-9889 .- 1467-9566. ; 34:8, s. 1156-1169
-
Tidskriftsartikel (refereegranskat)abstract
- This article focuses on individuals who are growing old with chronic illnesses and early onset impairments. Their experience of illness complications, bodily and functional losses is similar to what Bury has referred to as a biographical disruption. However, whereas Bury argues that a chronic illness amounts to a critical situation for the individual, partly due to its unexpected nature, this does not apply to the participants in our two studies. A second difference concerns Bury’s implicit suggestion that the disruption is a single event that is characteristic of the early stage of a chronic illness. Repeated disruptions seemed to shape the lives of several of those interviewed. At the same time, this article challenges studies which suggest that the notion of disruption is less relevant to people in later life and to those who have experienced difficult lives, and also questions the argument that continuity rather than change characterises the lives of people who have had chronic conditions since their early years. In its approach, the article responds toWilliams’ request for studies in the sociology of chronic illness that extend the predominant biographical focus on the middle years of life to both ends of the life course.
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| 45. |
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| 46. |
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| 47. |
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