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- Bastard, P, et al.
(författare)
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Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- 2022
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Ingår i: Science immunology. - : American Association for the Advancement of Science (AAAS). - 2470-9468. ; 78:7490, s. eabp8966-
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Tidskriftsartikel (refereegranskat)abstract
- Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
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| 3. |
- Bigler, Christian, et al.
(författare)
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Holocene environmental change at Lake Njulla (999 m asl), northern Sweden : a comparison with four small nearby lakes along an altitudinal gradient
- 2003
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Ingår i: Journal of Paleolimnology. - 0921-2728 .- 1573-0417. ; 29:1, s. 13-29
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Tidskriftsartikel (refereegranskat)abstract
- We assess Holocene environmental change at alpine Lake Njulla (68degrees22'N, 18degrees42'E, 999 m a.s.l.) in northernmost Sweden using sedimentary remains of chironomid head capsules and diatoms. We apply regional calibration sets to quantitatively reconstruct mean July air temperature (using chironomids and diatoms) and lake-water pH (using diatoms). Both chironomids and diatoms infer highest temperatures (1.7-2.3degreesC above present-day estimates, including, a correction for glacio-isostatic land up-lift by 0.6degreesC) during the early Holocene (c. 9,500-8,500 cal. yrs BP). Diatoms suggest a decreasing lake-water pH trend (c. 0.6 pH units) since the early Holocene. Using detrended canonical correspondence analysis (DCCA), we compare the Holocene development of diatom communities in Lake Njulla with four other nearby lakes (Lake 850, Lake Tibetanus, Vuoskkujavri, Vuolep Njakajaure) located along an altitudinal gradient. All five lakes show similar initial DCCA scores after deglaciation, suggesting that similar environmental processes such as high erosion rates and low light availability associated with high summer temperature appear to have regulated the diatom community, favouring high abundances of Fragilaria species. Subsequently, the diatom assemblages develop in a directional manner, but timing and scale of development differ substantially between lakes. This is attributed primarily to differences in the local geology, which is controlling the lake-water pH. Imposed on the basic geological setting, site-specific processes such as vegetation development, climate, hydrological setting and in-lake processes appear to control lake development in northern Sweden.
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| 4. |
- Rubin, T., et al.
(författare)
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'Quantum-based realizations of the pascal' status and progress of the empir-project: quantumpascal
- 2022
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Ingår i: 6th TC16 Conference on Pressure and Vacuum Measurement 2022, Together with the 24th TC3 Conference on the Measurement of Force, Mass and Torque, the 14th TC5 Conference on the Measurement of Hardness, and the 5th TC22 Conference on Vibration Measurement. - : International Measurement Confederation (IMEKO). - 9781713870227
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Konferensbidrag (refereegranskat)abstract
- The QuantumPascal (QP) project combines the capabilities of 12 European institutions to enable traceable pressure measurements utilizing quantum-based methods that evaluate the number density instead of force per area to target the wide pressure range between 1 Pa and 3 MPa. This article summarizes the goals and results since the project start in June 2019.
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