| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
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| 3. |
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| 4. |
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| 5. |
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| 6. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 7. |
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| 8. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 9. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 10. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 11. |
- Chen, David, et al.
(författare)
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CHANGE-POINT ALTERATIONS OF EXTREME WATER LEVELS AND UNDERLYING CAUSES IN THE PEARL RIVER DELTA, CHINA
- 2009
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Ingår i: Rivers Research and Applications. - : Wiley. - 1535-1459 .- 1535-1467. ; 25, s. 1153-1168
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the Bayesian model and Lepage test were used to detect change point and to analyse associated statistical properties of high/low water levels in summer (June, July and August (JJA)) and winter (December, January and February (DJF)) months across the PRD (Pearl River Delta). The results indicate that: (1) two time intervals, that is 1979-1981 and 1988-1995, witness abrupt changes of SmH/SmL (summer mean high water level/summer mean low water level). The lower PRD is dominated by increased mean and coefficient of variation (Cv) of SmH. Increased mean but decreased Cv of SmL can be observed in the Mainstem Pearl River; (2) WmL (winter mean low water level) and WmH (winter mean high water level) of about 74% of the total stations have two change points occurred roughly during 1969-1971 and 1993-1995. First change points of WmH are mainly characterized by increased mean and Cv, but decreased mean and increased Cv of WmL can be observed across major parts of the PRD. The driving factors causing abrupt changes of water levels are various. Intensive human activities cannot be ignored, for example in-channel dredging and reallocation of the streamflow within the river channels due to human-induced topographical changes of river channel. Different responses of high/low water levels to externally influencing factors and interactions between influencing factors make the alterations of the water levels across the PRD more complicated. The findings of this paper will be helpful for the management of the PRD and human mitigation to natural hazards under the changing environment. Copyright (C) 2008 John Wiley & Sons, Ltd.
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| 12. |
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| 13. |
- Ellinghaus, David, et al.
(författare)
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Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
- 2013
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 145:2, s. 339-347
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies.METHODS: We sequenced whole exomes of 42 unrelated subjects with CD and 5 healthy subjects (controls) and then filtered single nucleotide variants by incorporating association results from meta-analyses of CD GWAS and in silico mutation effect prediction algorithms. We then genotyped 9348 subjects with CD, 2868 subjects with ulcerative colitis, and 14,567 control subjects and associated variants analyzed in functional studies using materials from subjects and controls and in vitro model systems.RESULTS: We identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with CD. These mutations increased proliferation of T cells and secretion of cytokines on activation and increased expression of the adhesion molecule L-selectin. A common CD risk allele, identified in GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mononuclear cells (combined P = 1.6 x 10(-8)). We identified an association between CD and a common missense variant, Val248Ala, in nuclear domain 10 protein 52 (NDP52) (P = 4.83 x 10(-9)). We found that this variant impairs the regulatory functions of NDP52 to inhibit nuclear factor kappa B activation of genes that regulate inflammation and affect the stability of proteins in Toll-like receptor pathways.CONCLUSIONS: We have extended the results of GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD. PRDM1 maps adjacent to a CD interval identified in GWAS and encodes a transcription factor expressed by T and B cells. NDP52 is an adaptor protein that functions in selective autophagy of intracellular bacteria and signaling molecules, supporting the role of autophagy in the pathogenesis of CD.
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| 14. |
- Erzurumluoglu, A. Mesut, et al.
(författare)
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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
- 2020
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Ingår i: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:10, s. 2392-2409
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Tidskriftsartikel (refereegranskat)abstract
- Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10-8 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. Sixteen SNVs were associated with at least one of the smoking behaviour traits (P < 5 × 10-8) in the discovery samples. Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a Bonferroni significance threshold (P < 4.5 × 10-3) with consistent direction of effect. A further 35 SNVs were associated with smoking behaviour traits in the discovery plus replication meta-analysis (up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2. Functional follow-up implied that decreased expression of REV3L may lower the probability of smoking initiation. The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.
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| 15. |
- Fang, Evandro F., et al.
(författare)
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A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks.
- 2020
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Ingår i: Ageing Research Reviews. - : Elsevier BV. - 1568-1637. ; 64
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Tidskriftsartikel (refereegranskat)abstract
- One of the key issues facing public healthcare is the global trend of an increasingly ageing society which continues to present policy makers and caregivers with formidable healthcare and socio-economic challenges. Ageing is the primary contributor to a broad spectrum of chronic disorders all associated with a lower quality of life in the elderly. In 2019, the Chinese population constituted 18 % of the world population, with 164.5 million Chinese citizens aged 65 and above (65+), and 26 million aged 80 or above (80+). China has become an ageing society, and as it continues to age it will continue to exacerbate the burden borne by current family and public healthcare systems. Major healthcare challenges involved with caring for the elderly in China include the management of chronic non-communicable diseases (CNCDs), physical frailty, neurodegenerative diseases, cardiovascular diseases, with emerging challenges such as providing sufficient dental care, combating the rising prevalence of sexually transmitted diseases among nursing home communities, providing support for increased incidences of immune diseases, and the growing necessity to provide palliative care for the elderly. At the governmental level, it is necessary to make long-term strategic plans to respond to the pressures of an ageing society, especially to establish a nationwide, affordable, annual health check system to facilitate early diagnosis and provide access to affordable treatments. China has begun work on several activities to address these issues including the recent completion of the of the Ten-year Health-Care Reform project, the implementation of the Healthy China 2030 Action Plan, and the opening of the National Clinical Research Center for Geriatric Disorders. There are also societal challenges, namely the shift from an extended family system in which the younger provide home care for their elderly family members, to the current trend in which young people are increasingly migrating towards major cities for work, increasing reliance on nursing homes to compensate, especially following the outcomes of the ‘one child policy’ and the ‘empty-nest elderly’ phenomenon. At the individual level, it is important to provide avenues for people to seek and improve their own knowledge of health and disease, to encourage them to seek medical check-ups to prevent/manage illness, and to find ways to promote modifiable health-related behaviors (social activity, exercise, healthy diets, reasonable diet supplements) to enable healthier, happier, longer, and more productive lives in the elderly. Finally, at the technological or treatment level, there is a focus on modern technologies to counteract the negative effects of ageing. Researchers are striving to produce drugs that can mimic the effects of ‘exercising more, eating less’, while other anti-ageing molecules from molecular gerontologists could help to improve ‘healthspan’ in the elderly. Machine learning, ‘Big Data’, and other novel technologies can also be used to monitor disease patterns at the population level and may be used to inform policy design in the future. Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades. This is the 2nd edition of the review paper (Fang EF et al., Ageing Re. Rev. 2015).
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| 16. |
- Haifeng, Jiang, et al.
(författare)
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Research on cyclists microscopic behaviour models at signalized intersection
- 2013
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Ingår i: Proceedings of the 16th International Conference Road Safety on Four Continents. - Linköping : Statens väg- och transportforskningsinstitut.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, video cameras and data analysis technologies have been used to collect and analyze image data of bicyclists at two signalized intersections in Beijing. Statistical analysis and nonlinear regression methods were conducted to develop a new simulation model to represent the behavior of cyclists. Various characteristics and behaviors of cyclists including speed distribution, acceleration of bicycle departing an intersection and deceleration of bicycle approaching an intersection and stopped distance of bicycles at signalized intersection have been studied. The results are useful for understanding the performance of bicycle traffic flow at signalized intersections. The simulation techniques, which consider bicyclist characteristics, has a strong application value, such as to estimate the capacity of signalized intersection for bicycle traffic and to build microscopic simulation models for mixed traffic.
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| 17. |
- Jiang, Pengfei, et al.
(författare)
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VLBI astrometry on the white dwarf pulsar AR Scorpii
- 2023
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 520:2, s. 2942-2951
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Tidskriftsartikel (refereegranskat)abstract
- AR Scorpii (AR Sco), the only-known radio-pulsing white dwarf binary, shows unusual pulsating emission at the radio, infrared, optical, and ultraviolet bands. To determine its astrometric parameters at the radio band independently, we conducted multi-epoch Very Long Baseline Interferometry (VLBI) phase-referencing observations with the European VLBI Network at 5 GHz and the Chinese VLBI Network plus the Warkworth 30-m telescope (New Zealand) at 8.6 GHz. By using the differential VLBI astrometry, we provide high-precision astrometric measurements on the parallax (pi = 8.52(-0.07)(+0.04) mas) and proper motion (mu(alpha) = 9.48(-0.07)(+0.04) mas yr(-1), mu(delta) = -51.32(-0.38)(+0.22) mas yr (-1)). The new VLBI results agree with the optical Gaia astrometry. Our kinematic analysis reveals that the Galactic space velocities of AR Sco are quite consistent with that of both intermediate polars and polars. Combined with the previous tightest VLBI constraint on the size, our parallax distance suggests that the radio emission of AR Sco should be located within the light cylinder of its white dwarf.
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| 18. |
- Liu, Jiang, et al.
(författare)
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Rice-paddy field acts as a buffer system to decrease the terrestrial characteristics of dissolved organic matter exported from a typical small agricultural watershed in the Three Gorges Reservoir Area, China
- 2019
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Ingår i: Environmental Science and Pollution Research. - : SPRINGER HEIDELBERG. - 0944-1344 .- 1614-7499. ; 26:23, s. 23873-23885
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Tidskriftsartikel (refereegranskat)abstract
- Agricultural watersheds are a crucial contributor of terrestrial dissolved organic matter (DOM) for the adjacent aquatic environment. Recently, ecological engineering of the buffer zone such as a rice-paddy field was established to reduce the export of nutrients and contaminants from a small agricultural watershed. However, the potential of the rice-paddy field to reduce the terrestrial signature of DOM is unclear. Therefore, two small agricultural sub-catchments (i.e., sub-1 and sub-2) with different land uses and hill slope angles in the Three Gorges Reservoir (TGR) area of China were studied from 2014 to 2015. The results showed that the terrestrial DOM signals are indicated by optical indices (SUVA(254), S-R, fluorescence index) in the steeper and more forest covered, but rice-paddy field buffered sub-catchment (i.e., sub-2) decreased significantly, as compared to the reference sub-catchment (i.e., sub-1). Regardless of seasonal variations, the rice-paddy field retained a buffering role to reduce the terrestrial property of DOM and the highest capacity was observed during the rice-growth period. However, during storm events, the differences of DOM properties for two sub-catchments were not significant, because the buffer system was weakened. Finally, environmental implications of the role of such a buffer zone in the TGR areas are discussed. These results demonstrate that rice-paddy fields are successful in mitigating the terrestrial property of exported DOM, but the weaker performance during storm events still needs to be considered.
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| 19. |
- Ma, Jiang-Jiang, et al.
(författare)
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Ultralow thermal conductivity and anisotropic thermoelectric performance in layered materials LaMOCh (M = Cu, Ag; Ch = S, Se)
- 2022
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Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry. - 1463-9076 .- 1463-9084. ; 24:35, s. 21261-21269
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Tidskriftsartikel (refereegranskat)abstract
- In layered materials with the stacking axis perpendicular to the basal plane, anharmonicity strongly affects phonon propagation due to weak interlayer coupling, which is helpful to reduce the lattice thermal conductivity and improve the thermoelectric (TE) performance significantly. By combining first-principles calculations and the Boltzmann transport equation, we systematically analyzed and evaluated the lattice thermal conductivity and TE properties of LaMOCh (M = Cu, Ag; Ch = S, Se). The results indicate that these layered materials exhibit ultralow lattice thermal conductivities of 0.24-0.37 W m(-1) K-1 along the interlayer direction at room temperature. The low lattice thermal conductivities have been analyzed from some inherent phonon properties, such as low acoustic phonon group velocity, large Gruneisen parameters, and a short phonon relaxation time. Originating from their natural layered crystal structure, the thermal and electronic transports (i.e., thermal conductivity, Seebeck coefficient, and electrical conductivity) are both highly anisotropic between their intralayer and interlayer directions. Finally, we obtained ZT values of 1.17 and 1.26 at 900 K along the interlayer direction for n-type LaCuOSe and LaAgOSe, respectively. Generally, LaMOSe exhibit larger anisotropy than LaMOS, in both n- and p-types of doping. Our findings of low thermal conductivities and large anisotropic TE performances of these layered systems should stimulate much attention in BiCuOSe and alike layered TE families.
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| 20. |
- Song, Guohe, et al.
(författare)
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TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway
- 2016
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Ingår i: Journal of Experimental & Clinical Cancer Research. - London, United Kingdom : BioMed Central (BMC). - 1756-9966. ; 35:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate its biological function and clinical significance in human colon cancer.Methods: We analyzed the expression of TIMP1 in both public database (Oncomine and TCGA) and 94 cases of primary colon cancer and matched normal colon tissue specimens. The underlying mechanisms of altered TIMP1 expression on cell tumorigenesis, proliferation, and metastasis were explored in vitro and in vivo.Results: TIMP1 was overexpressed in colon tumorous tissues and lymph node metastasis specimens than in normal tissues. The aberrant expression of TIMP1 was significantly associated with the regional lymph node metastasis (p = 0.033), distant metastasis (p = 0.039), vascular invasion (p = 0.024) and the American Joint Committee on Cancer (AJCC) stage (p = 0.026). Cox proportional hazards model showed that TIMP1 was an independent prognostic indicator of disease-free survival (HR = 2.603, 95 % CI: 1.115-6.077, p = 0.027) and overall survival (HR = 2.907, 95 % CI: 1.254-6.737, p = 0.013) for patients with colon cancer. Consistent with this, our findings highlight that suppression of TIMP1 expression decreased proliferation, and metastasis but increased apoptosis by inducing TIMP1 specific regulated FAK-PI3K/AKT and MAPK pathway.Conclusion: TIMP1 might play an important role in promoting tumorigenesis and metastasis of human colon cancer and function as a potential prognostic indicator for colon cancer.
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| 21. |
- Tian, Yu-Peng, et al.
(författare)
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Investigations and facile synthesis of a series of novel multi-functional two-photon absorption materials
- 2007
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Ingår i: Journal of Materials Chemistry. - : Royal Society of Chemistry (RSC). - 0959-9428 .- 1364-5501. ; 17:34, s. 3646-3654
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Tidskriftsartikel (refereegranskat)abstract
- Six centrosymmetric D-(pi-A)(3) structural triphenylamine derivatives that can be used as two- photon photopolymerization and optical data storage chromophores, tris[ 4-( 4- pyridylethenyl) phenyl] amine ( 1), tris[ 4-( 2- pyridylethenyl) phenyl] amine ( 2), tris( 4- cyanoethenylphenyl) amine ( 3), tris[ 4- butylacrylatephenyl] amine ( 4), tris[ 4- methylacrylatephenyl] amine ( 5) and tris[ 4- acrylicethenylphenyl] amine ( 6), have been successfully synthesized via a triple palladium-catalyzed Heck coupling reaction, and the novel chromophores were fully characterized by elemental analysis, IR, (1)H-NMR and ESIMS. The structure for 3 was determined by single crystal X-ray diffraction study. One- and two-photon absorption and fluorescence in various solvents were experimentally investigated. Two-photon initiated polymerization microfabrication and optical data recording experiments were carried out under 780 nm laser radiation, and the possible polymerization mechanism is discussed based on theoretical calculations. All the six chromophores have relatively large two-photon absorption crosssections, and exhibit optical memory and highly efficient two-photon initiated polymerization abilities.
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| 22. |
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| 23. |
- Zhang, Qiang, et al.
(författare)
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Climate changes and their impacts on water resources in the arid regions : a case study of the Tarim River basin, China
- 2010
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Ingår i: Stochastic environmental research and risk assessment (Print). - : Springer Science and Business Media LLC. - 1436-3240 .- 1436-3259. ; 24:3, s. 349-358
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Tidskriftsartikel (refereegranskat)abstract
- Streamflow series of five hydrological stations were analyzed with aim to indicate variability of water resources in the Tarim River basin. Besides, impacts of climate changes on water resources were investigated by analyzing daily precipitation and temperature data of 23 meteorological stations covering 1960-2005. Some interesting and important results were obtained: (1) the study region is characterized by increasing temperature, however, only temperature in autumn is in significant increasing trend; (2) precipitation changes present different properties. Generally, increasing precipitation can be detected. However, only the precipitation in the Tienshan mountain area is in significant increasing trend. Annual streamflow of major rivers of the Tarim River basin are not in significant trends, except that of the Akesu River which is in significantly increasing trend. Due to the geomorphologic properties of the Tienshan mountain area, precipitation in this area demonstrates significant increasing trend and which in turn leads to increasing streamflow of the Akesu River. Due to the fact that the sources of streamflow of the rivers in the Tarim River basin are precipitation and melting glacial, both increasing precipitation and accelerating melting ice has the potential to cause increasing streamflow. These results are of practical and scientific merits in basin-scale water resource management in the arid regions in China under the changing environment.
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| 24. |
- Aad, G, et al.
(författare)
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- 2015
-
swepub:Mat__t
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| 25. |
- Barucca, G., et al.
(författare)
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The potential of Λ and Ξ- studies with PANDA at FAIR
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
-
Tidskriftsartikel (refereegranskat)abstract
- The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.
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| 26. |
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| 27. |
- Bin, Jiang, et al.
(författare)
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Exploring Human Mobility Patterns Based on Location Information of US Flights
- 2011
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A range of early studies have been conducted to illustrate human mobility patterns using differenttracking data, such as dollar notes, cell phones and taxicabs. Here, we explore human mobility patternsbased on massive tracking data of US flights. Both topological and geometric properties are examinedin detail. We found that topological properties, such as traffic volume (between airports) and degree ofconnectivity (of individual airports), including both in- and outdegrees, follow a power lawdistribution but not a geometric property like travel lengths. The travel lengths exhibit an exponentialdistribution rather than a power law with an exponential cutoff as previous studies illustrated. Wefurther simulated human mobility on the established topologies of airports with various movingbehaviors and found that the mobility patterns are mainly attributed to the underlying binary topologyof airports and have little to do with other factors, such as moving behaviors and geometric distances.Apart from the above findings, this study adopts the head/tail division rule, which is regularity behindany heavy-tailed distribution for extracting individual airports. The adoption of this rule for dataprocessing constitutes another major contribution of this paper.
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| 28. |
- Bin, Jiang, 1965-, et al.
(författare)
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Scaling of Geographic Space as a Universal Rule for Mapping or Cartographic Generalization
- 2011
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Mapping, or cartographic generalization in particular, is a process of producing maps at different levels of detail by retaining essential properties of the underlying geographic space. In this paper, we explore how mapping or cartographic generalization process can be guided by the underlying scaling of geographic space. Scaling refers to the fact that in a large geographic area small objects are far more common than large ones. In the corresponding probability density function, this scaling is reflected as a heavy tailed distribution such as a power law, lognormal, and exponential distribution. In essence, any heavy tailed distribution consists of the head of the distribution (with a low percentage of objects) and the tail of the distribution (with a high percentage of objects). We therefore suggest that the objective of the mapping process is to retain the objects in the head yet to eliminate those in the tail. We applied this selection principle to several generalization experiments, and found that the scaling of geographic space can indeed be a universal rule for mapping and cartographic generalization. We further relate the universal rule to T\"opfer's radical law (or trained cartographers' decision making in general), and illustrate several advantages of the universal rule compared to the radical law.
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| 29. |
- Bixby, H., et al.
(författare)
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
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Tidskriftsartikel (refereegranskat)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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| 30. |
- Burr, Alister, et al.
(författare)
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MIMO Truncated Shannon Bound for System Level Capacity Evaluation of Wireless Networks
- 2012
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Ingår i: IEEE Wireless Communications and Networking Conference, Paris, France, Apr. 2012. - 9781467306829 ; , s. 268-272
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Konferensbidrag (refereegranskat)abstract
- We outline a general method for modelling the capacity of a MIMO link within a wireless, assuming that capacity of a link is a random function of SNR and signal to interference ratio (SIR), since the maximum link throughput depends on the random channel of both the user's signal and the interference. We show how a look-up table for the CDF of this random function can be obtained by link-level simulation in the presence of interference having the same characteristics as the interference found in the target network. We also exploit the Truncated Shannon Bound (TSB) to estimate the resulting capacity obtained in practice in a system using adaptive modulation and coding on the link level.
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| 31. |
- Chang, Haigang, et al.
(författare)
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Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking
- 2020
-
Ingår i: Frontiers in Psychiatry. - : Frontiers Media SA. - 1664-0640. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Deep brain stimulation (DBS) modulates the neuronal activity in specific brain circuits and has been recently considered as a promising intervention for refractory addiction. The insula cortex is the hub of interoception and is known to be involved in different aspects of substance use disorder. In the present study, we investigate the effects of continuous high frequency DBS in the anterior insula (AI) on drug-seeking behaviors and examined the molecular mechanisms of DBS action in morphine-addicted rats. Sprague-Dawley rats were trained to the morphine-conditioned place preference (CPP, day 1-8) followed by bilaterally implanted with DBS electrodes in the AI (Day 10) and recovery (Day 10-15). Continuous high-frequency (HF) -DBS (130 Hz, 150 mu A, 90 mu s) was applied during withdrawal (Day 16-30) or extinction sessions. CPP tests were conducted on days 16, 30, 40 during withdrawal session and several rats were used for proteomic analysis on day 30. Following the complete extinction, morphine-CPP was reinstated by a priming dose of morphine infusion (2 mg/kg). The open field and novel objective recognition tests were also performed to evaluate the DBS side effect on the locomotion and recognition memory. Continuous HF-DBS in the AI attenuated the expression of morphine-CPP post-withdrawal (Day 30), but morphine addictive behavior relapsed 10 days after the cessation of DBS (Day 40). Continuous HF-DBS reduced the period to full extinction of morphine-CPP and blocked morphine priming-induced recurrence of morphine addiction. HF-DBS in the AI had no obvious effect on the locomotor activity and novel objective recognition and did not cause anxiety-like behavior. In addition, our proteomic analysis identified eight morphine-regulated proteins in the AI and their expression levels were reversely changed by HF-DBS. Continuous HF-DBS in the bilateral anterior insula prevents the relapse of morphine place preference after withdrawal, facilitates its extinction, blocks the reinstatement induced by morphine priming and reverses the expression of morphine-regulated proteins. Our findings suggest that manipulation of insular activity by DBS could be a potential intervention to treat substance use disorder, although future research is warranted.
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| 32. |
- Chen, Dongfeng, et al.
(författare)
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Better Prognosis of Patients with Glioma Expressing FGF2-Dependent PDGFRA Irrespective of Morphological Diagnosis.
- 2013
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- Signaling of platelet derived growth factor receptor alpha (PDGFRA) is critically involved in the development of gliomas. However, the clinical relevance of PDGFRA expression in glioma subtypes and the mechanisms of PDGFRA expression in gliomas have been controversial. Under the supervision of morphological diagnosis, analysis of the GSE16011 and the Repository of Molecular Brain Neoplasia Data (Rembrandt) set revealed enriched PDGFRA expression in low-grade gliomas. However, gliomas with the top 25% of PDGFRA expression levels contained nearly all morphological subtypes, which was associated with frequent IDH1 mutation, 1p LOH, 19q LOH, less EGFR amplification, younger age at disease onset and better survival compared to those gliomas with lower levels of PDGFRA expression. SNP analysis in Rembrandt data set and FISH analysis in eleven low passage glioma cell lines showed infrequent amplification of PDGFRA. Using in vitro culture of these low passage glioma cells, we tested the hypothesis of gliogenic factor dependent expression of PDGFRA in glioma cells. Fibroblast growth factor 2 (FGF2) was able to maintain PDGFRA expression in glioma cells. FGF2 also induced PDGFRA expression in glioma cells with low or non-detectable PDGFRA expression. FGF2-dependent maintenance of PDGFRA expression was concordant with the maintenance of a subset of gliogenic genes and higher rates of cell proliferation. Further, concordant expression patterns of FGF2 and PDGFRA were detected in glioma samples by immunohistochemical staining. Our findings suggest a role of FGF2 in regulating PDGFRA expression in the subset of gliomas with younger age at disease onset and longer patient survival regardless of their morphological diagnosis.
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| 33. |
- Chen, XÍ, et al.
(författare)
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TDHQ Enabling Fine-granularity Adaptive Loading for SSB-DMT Systems
- 2018
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Ingår i: IEEE Photonics Technology Letters. - : Institute of Electrical and Electronics Engineers Inc.. - 1041-1135 .- 1941-0174. ; 30:19, s. 1687-1690
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Tidskriftsartikel (refereegranskat)abstract
- In this letter, we introduce time domain hybrid quadrature amplitude modulation (TDHQ) for the single sideband (SSB) discrete multi-tone (DMT) systems. Experimental results reveal that with a single precoding set and the proposed adaptive loading algorithm, the TDHQ scheme can achieve finer granularity and therefore smoother continuous growth of data rate than that with the conventional quadrature amplitude modulation (QAM). Besides, thanks to the frame construction and the tailored mapping rule, the scheme with TDHQ has an obviously better peak to average power ratio (PAPR).
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| 34. |
- Chen, Zhi, et al.
(författare)
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Large-Area Crystalline Zeolitic Imidazolate Framework Thin Films
- 2021
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 60:25, s. 14124-14130
-
Tidskriftsartikel (refereegranskat)abstract
- We report that continuous MOF films with highly controlled thickness (from 44 to 5100 nm) can be deposited over length scales greater than 80 centimeters by a facile, fast, and cost-effective spray-coating method. Such success relies on our discovery of unprecedented perfectly dispersed colloidal solutions consisting of amorphous MOF nanoparticles, which we adopted as precursors that readily converted to the crystalline films upon low-temperature in situ heating. The colloidal solutions allow for the fabrication of compact and uniform MOF films on a great deal of substrates such as fluorine-doped tin oxide, glass, SiO2, Al2O3, Si, Cu, and even flexible polycarbonate, widening their technological applications where substrates are essential. Despite the present work focuses on the fabrication of uniform cobalt-(2-methylimidazole)2 and zinc-(2-methylimidazole)2 films, our findings mark a great possibility in producing other high-quality MOF thin films on a large scale.
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| 35. |
- Cheng, Yirui, et al.
(författare)
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Comparison of serum exosome isolation methods on co-precipitated free microRNAs.
- 2020
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Ingår i: PeerJ. - : PeerJ. - 2167-8359. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Exosomes are nano-sized extracellular vesicles containing different biomolecules such as proteins and microRNAs (miRNAs) that mediate intercellular communication. Recently, numerous studies have reported the important functions of exosomal miRNAs in disease development and the potential clinical application as diagnostic biomarkers. Up to now, the most commonly used methods to extract exosomes are ultracentrifugation (UC) and precipitation-based commercial kit (e.g., ExoQuick). Generally, both UC and ExoQuick method could co-isolate contaminating proteins along with exosomes, with the UC method yielding even purer exosomes than ExoQuick. However, the comparison of these two methods on co-precipitated free miRNAs is still unknown.Methods: In this study, we isolated exosomes from the human serum with exogenously added cel-miR-39 by UC and ExoQuick and compared the proportion of cel-miR-39 co-precipitated with exosomes extracted by these two methods.Results: Using exogenous cel-miR-39 as free miRNAs in serum, we concluded that ExoQuick co-isolates a small proportion of free miRNAs while UC hardly precipitates any free miRNAs. We also found that incubation at 37 °C for 1 h could decrease the proportion of free miRNAs, and exosomal miRNAs like miR-126 and miR-152 also decreased when RNase A was used. In conclusion, our findings provide essential information about the details of serum exosome isolation methods for further research on exosomal miRNAs.
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| 36. |
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| 37. |
- Danielsson, Marie, et al.
(författare)
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Chemical and transcriptional responses of Norway spruce genotypes with different susceptibility to Heterobasidion spp. infection
- 2011
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Ingår i: BMC Plant Biology. - : BioMed Central (BMC). - 1471-2229. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Norway spruce [Picea abies (L.) Karst.] is one of the most important conifer species in Europe. The wood is economically important and infections by wood-rotting fungi cause substantial losses to the industry. The first line of defence in a Norway spruce tree is the bark. It is a very efficient barrier against infection based on its mechanical and chemical properties. Once an injury or an infection is recognized by the tree, induced defences are activated. In this study we examined transcriptional response, using 454-sequencing, and chemical profiles in bark of Norway spruce trees with different susceptibility to Heterobasidion annosum s.l. infection. The aim was to find associations between the transcriptome and chemical profiles to the level of susceptibility to Heterobasidion spp. in Norway spruce genotypes.Results: Both terpene and phenol compositions were analysed and at 28 days post inoculation (dpi) high levels of 3-carene was produced in response to H. annosum. However, significant patterns relating to inoculation or to genotypes with higher or lower susceptibility could only be found in the phenol fraction. The levels of the flavonoid catechin, which is polymerized into proanthocyanidins (PA), showed a temporal variation; it accumulated between 5 and 15 dpi in response to H. annosum infection in the less susceptible genotypes. The transcriptome data suggested that the accumulation of free catechin was preceded by an induction of genes in the flavonoid and PA biosynthesis pathway such as leucoanthocyanidin reductase. Quantitative PCR analyses verified the induction of genes in the phenylpropanoid and flavonoid pathway. The qPCR data also highlighted genotype-dependent differences in the transcriptional regulation of these pathways.Conclusions: The varying dynamics in transcriptional and chemical patterns displayed by the less susceptible genotypes suggest that there is a genotypic variation in successful spruce defence strategies against Heterobasidion. However, both high levels of piceasides and flavonoids in the less susceptible genotypes suggested the importance of the phenolic compounds in the defence. Clearly an extended comparison of the transcriptional responses in the interaction with Heterobasidion between several independent genotypes exhibiting reduced susceptibility is needed to catalogue mechanisms of successful host defence strategies.
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| 38. |
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| 39. |
- Ding, Jiangwei, et al.
(författare)
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All Roads Lead to Rome? : Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
- 2022
-
Ingår i: Frontiers in Neurology. - : Frontiers Media S.A.. - 1664-2295. ; 13
-
Forskningsöversikt (refereegranskat)abstract
- Background: Dravet syndrome (DS) is a severe epileptic encephalopathy mainly caused by haploinsufficiency of the gene SCN1A, which encodes the voltage-gated sodium channel NaV1. 1 in the brain. While SCN1A mutations are known to be the primary cause of DS, other genes that may cause DS are poorly understood. Several genes with pathogenic mutations result in DS or DS-like phenotypes, which may require different drug treatment approaches. Therefore, it is urgent for clinicians, especially epilepsy specialists to fully understand these genes involved in DS in addition to SCN1A. Particularly for healthcare providers, a deep understanding of these pathogenic genes is useful in properly selecting and adjusting drugs in a more effective and timely manner.Objective: The purpose of this study was to identify genes other than SCN1A that may also cause DS or DS-like phenotypes. Methods: A comprehensive search of relevant Dravet syndrome and severe myoclonic epilepsy in infancy was performed in PubMed, until December 1, 2021. Two independent authors performed the screening for potentially eligible studies. Disagreements were decided by a third, more professional researcher or by all three. The results reported by each study were narratively summarized.Results: A PubMed search yielded 5,064 items, and other sources search 12 records. A total of 29 studies published between 2009 and 2021 met the inclusion criteria. Regarding the included articles, seven studies on PCDH19, three on SCN2A, two on SCN8A, five on SCN1B, two on GABRA1, three on GABRB3, three on GABRG2, and three on STXBP1 were included. Only one study was recorded for CHD2, CPLX1, HCN1 and KCNA2, respectively. It is worth noting that a few articles reported on more than one epilepsy gene.Conclusion: DS is not only identified in variants of SCN1A, but other genes such as PCDH19, SCN2A, SCN8A, SCN1B, GABRA1, GABRB3, GABRG2, KCNA2, CHD2, CPLX1, HCN1A, STXBP1 can also be involved in DS or DS-like phenotypes. As genetic testing becomes more widely available, more genes associated with DS and DS-like phenotypes may be identified and gene-based diagnosis of subtypes of phenotypes in this spectrum may improve the management of these diseases in the future.
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| 40. |
- Dong, Jianbo, et al.
(författare)
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Venice: Exploring Server Architectures for Effective Resource Sharing
- 2016
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Ingår i: Proceedings - International Symposium on High-Performance Computer Architecture. - 1530-0897. - 9781467392112 ; 2016-April, s. 507-518
-
Konferensbidrag (refereegranskat)abstract
- Consolidated server racks are quickly becoming the backbone of IT infrastructure for science, engineering, and business, alike. These servers are still largely built and organized as when they were distributed, individual entities. Given that many fields increasingly rely on analytics of huge datasets, it makes sense to support flexible resource utilization across servers to improve cost-effectiveness and performance. We introduce Venice, a family of data-center server architectures that builds a strong communication substrate as a first-class resource for server chips. Venice provides a diverse set of resource-joining mechanisms that enables user programs to efficiently leverage non-local resources.To better understand the implications of design decisionsabout system support for resource sharing we have constructed a hardware prototype that allows us to more accurately measure end-to-end performance of at-scale applications and to explore tradeoffs among performance, power, and resource-sharing transparency. We present results from our initial studies analyzing these tradeoffs when sharing memory, accelerators, or NICs. We find that it is particularly important to reduce or hide latency, that data-sharing access patterns should match the features of the communication channels employed, and that inter-channel collaboration can be exploited for better performance.
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| 41. |
- Du, He, et al.
(författare)
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Scheduling and analysis of real-time task graph models with nested locks
- 2021
-
Ingår i: Journal of systems architecture. - : Elsevier. - 1383-7621 .- 1873-6165. ; 114
-
Tidskriftsartikel (refereegranskat)abstract
- Locking protocol is a crucial component in scheduling of real-time systems. The digraph real-time task model (DRT) is the state-of-the-art graph-based task model, which is a generalization of most previous real-time task models. To our best knowledge, the only work addressing resource sharing problem in DRT task model proposes a resource sharing protocol, called ACP, as well as a scheduling strategy EDF+ACP. Although EDF+ACP is optimal for scheduling DRT tasks with non-nested resource access, it cannot handle the situation of nested resource accesses. In this paper, we propose a new protocol, called N-ACP, by modifying ACP to manage nested resource accesses in task graph models. We apply N-ACP to EDF scheduling to obtain a new scheduling strategy EDF+N-ACP. We develop schedulability analysis techniques for EDF+N-ACP and evaluate its performance by a widely-used quantitative metrics speedup factor. We derive its speedup factor as a function of the maximal nesting level of resource accesses in the system.
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| 42. |
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| 43. |
- Fang, Jing, et al.
(författare)
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Depression Prevalence in Postgraduate Students and Its Association With Gait Abnormality
- 2019
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Ingår i: IEEE Access. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2169-3536. ; 7, s. 174425-174437
-
Tidskriftsartikel (refereegranskat)abstract
- In recent years, an increasing number of university students are found to be at high risk of depression. Through a large scale depression screening, this paper finds that around 6.5% of the university postgraduate students in China experience depression. We then investigate whether the gait patterns of these individuals have already changed as depression is suggested to associate with gait abnormality. Significant differences are found in several spatiotemporal, kinematic and postural gait parameters such as walking speed, stride length, head movement, vertical head posture, arm swing, and body sway, between the depressed and non-depressed groups. Applying these features to classifiers with different machine learning algorithms, we examine whether natural gait analysis may serve as a convenient and objective tool to assist in depression recognition. The results show that when using a random forest classifier, the two groups can be classified automatically with a maximum accuracy of 91.58%. Furthermore, a reasonable accuracy can already be achieved by using parameters from the upper body alone, indicating that upper body postures and movements can effectively contribute to depression analysis.
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| 44. |
- Figueroa, Andres, et al.
(författare)
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Approximate clustering of fingerprint vectors with missing values
- 2005
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Ingår i: Proceedings of the 2005 Australasian symposium on Theory of computing. - 1445-1336. - 1920682236 ; , s. 57-60
-
Konferensbidrag (refereegranskat)abstract
- We study the problem of clustering fingerprints with at most p missing values (CMV (p) for short) naturally arising in oligonucleotide fingerprinting, which is an efficient method for characterizing DNA clone libraries.We show that already CMV(2) is NP-hard. We also show that a greedy algorithm yields a min(1 + ln n, 2+pln l) approximation for CMV(p), and can be implemented to run in O(nl2p) time. Furthermore, we introduce other variants of the problem of clustering fingerprints with at most p missing values based on slightly different optimization criteria and show that they can be approximated in polynomial time with ratios 22p-1 and 2(1 - [EQUATION]), respectively.
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| 45. |
- Figueroa, Andres, et al.
(författare)
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Approximate clustering of incomplete fingerprints
- 2008
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Ingår i: Journal of Discrete Algorithms. - : Elsevier. - 1570-8667 .- 1570-8675. ; 6:1, s. 103-108
-
Tidskriftsartikel (refereegranskat)abstract
- We study the problem of clustering fingerprints with at most p missing values (CMV(p) for short) naturally arising in oligonucleotide fingerprinting, which is an efficient method for characterizing DNA clone libraries. We show that already CMV(2) is NP-hard. We also show that a greedy algorithm yields a min(1+ln n , 2+pln l) approximation for CMV(p), and can be implemented to run in O(nl2^p) time. We also introduce other variants of the problem of clustering incomplete fingerprints based on slightly different optimization criteria and show that they can be approximated in polynomial time with ratios 2^(2p−1) and 2(1-1/(2^(2p))), respectively.
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| 46. |
- Gill, Dipender, et al.
(författare)
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ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels : a Mendelian randomization study
- 2020
-
Ingår i: Royal Society Open Science. - : ROYAL SOC. - 2054-5703. ; 7:11
-
Tidskriftsartikel (refereegranskat)abstract
- Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circulating ACE2 levels. We observed no consistent evidence of an association of genetically predicted serum ACE levels with any of our outcomes. There was weak evidence for an association of genetically predicted serum ACE levels with ACE2 gene expression in the Lung eQTL Consortium (p = 0.014), but this finding did not replicate. There was evidence of a positive association of genetic liability to type 2 diabetes mellitus with lung ACE2 gene expression in the Gene-Tissue Expression (GTEx) study (p = 4 x 10(-4)) and with circulating plasma ACE2 levels in the INTERVAL study (p = 0.03), but not with lung ACE2 expression in the Lung eQTL Consortium study (p = 0.68). There were no associations of genetically proxied liability to the other cardiometabolic traits with any outcome. This study does not provide consistent evidence to support an effect of serum ACE levels (as a proxy for ACE inhibitors) or cardiometabolic risk factors on lung ACE2 and TMPRSS2 expression or plasma ACE2 levels.
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| 47. |
- Gu, Peng, et al.
(författare)
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A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis
- 2023
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Ingår i: Cellular & Molecular Immunology. - London : Nature Publishing Group. - 1672-7681 .- 2042-0226. ; 20:10, s. 1156-1170
-
Tidskriftsartikel (refereegranskat)abstract
- The gut microbiome is recognized as a key modulator of sepsis development. However, the contribution of the gut mycobiome to sepsis development is still not fully understood. Here, we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis, and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture (CLP)-challenged mice and Escherichia coli-challenged pigs. Integrative metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate (PPA) enhanced the bactericidal activity of macrophages and reduced organ damage during sepsis. Mechanistically, PPA directly binds to sirtuin 2 (SIRT2) and increases reactive oxygen species (ROS) production for eventual bacterial clearance. Importantly, PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in patients. Our findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development. © 2023, The Author(s), under exclusive licence to CSI and USTC.
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| 48. |
- Gu, Shi-Ran, et al.
(författare)
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Phylogeny and re-circumscription of Cheniella (Leguminosae: Cercidoideae) based on plastome data and morphology, with description of three new species
- 2024
-
Ingår i: TAXON. - 0040-0262 .- 1996-8175. ; 73:2, s. 475-502
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Tidskriftsartikel (refereegranskat)abstract
- Subfamily Cercidoideae is an early-diverging lineage of Leguminosae, within which the number and classification of genera have been controversial. Cheniella is a recently described genus in the Cercidoideae which requires revision and testing of its monophyly and circumscription. Here we infer the phylogenetic position and infrageneric relationships of Cheniella as well as the intergeneric relationships of Cercidoideae using 48 newly sequenced plastid genomes, including 34 individuals representing all species of Cheniella. Our phylogenetic analyses yield a well-resolved tree of Cercidoideae with robust support at most nodes. We also present morphological studies through field work and herbarium studies to re-assess the classification and circumscription of the genus. Based on the results of molecular analyses and morphological studies combined with distribution data, we broaden the circumscription of Cheniella to comprise a total of 15 species and 3 subspecies, including three new species (C. hechiensis, C. longistaminea, C. pubicarpa), one new combination (C. tianlinensis) and one new status and combination (C. longipes).
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| 49. |
- Guo, Tao, et al.
(författare)
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An Improved LSSVM Model for Intelligent Prediction of the Daily Water Level
- 2019
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Ingår i: Energies. - : MDPI. - 1996-1073. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Daily water level forecasting is of significant importance for the comprehensive utilization of water resources. An improved least squares support vector machine (LSSVM) model was introduced by including an extra bias error control term in the objective function. The tuning parameters were determined by the cross-validation scheme. Both conventional and improved LSSVM models were applied in the short term forecasting of the water level in the middle reaches of the Yangtze River, China. Evaluations were made with both models through metrics such as RMSE (Root Mean Squared Error), MAPE (Mean Absolute Percent Error) and index of agreement (d). More accurate forecasts were obtained although the improvement is regarded as moderate. Results indicate the capability and flexibility of LSSVM-type models in resolving time sequence problems. The improved LSSVM model is expected to provide useful water level information for the managements of hydroelectric resources in Rivers.
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| 50. |
- Hao, Fuying, et al.
(författare)
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Design, crystal structures and enhanced frequency-upconverted lasing efficiencies of a new series of dyes from hybrid of inorganic polymers and organic chromophores
- 2009
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Ingår i: Journal of Materials Chemistry. - : RSC Publishing. - 0959-9428 .- 1364-5501. ; 19:48, s. 9163-9169
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Tidskriftsartikel (refereegranskat)abstract
- A new series of hybrid dyes, trans-4-(4′-N,N-dialkylaminostyryl)-N-methyl pyridinium [Cd(SCN)3−]n [alkyl = Me(1), Et(2), Pr(3) and n–Bu(4)] have been successfully synthesized from hybrids of inorganic polymers and organic chromophores. The structures of four new hybrid dyes were characterized by single-crystal X-ray diffraction first. The particular features of the hybrid dyes are (1) the inorganic anions form isolated polymeric one-dimensional zig-zag chains of [Cd(SCN)3−]n with an extended π-conjugation system within the polymeric –[M–S–C≡N]–M… chain and high polarizabilities; and (2) the organic cationic chromophores determine their optical properties. Experimental results revealed that the TPA cross-section values and overall energy conversion efficiencies of hybrid dyes with different alkyl pendant groups have obviously increased from 1 to 4, and in particular, have been substantially enhanced compared to their corresponding iodide analogues 1′–4′. Therefore, we speculate that such increases are attributable to arrangements of infinite anionic [Cd(SCN)3−]n chains and synergic effects with chromophore cations.
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