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1.
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2.
  • Klionsky, Daniel J., et al. (author)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Research review (peer-reviewed)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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3.
  • 2019
  • Journal article (peer-reviewed)
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4.
  • Beal, Jacob, et al. (author)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Journal article (peer-reviewed)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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5.
  • Gao, Zhi xin, et al. (author)
  • Progress of passive enhanced heat transfer tubes
  • 2017
  • In: Xiandai Huagong/Modern Chemical Industry. - 0253-4320. ; 37:3, s. 24-30
  • Research review (peer-reviewed)abstract
    • A review of several typical enhanced heat transfer tubes such as corrugated tube, transversally corrugated tube, twisted tube and spiral fluted tube, is carried out. Compared with smooth wall tube, these enhanced tubes have higher heat exchange capacity and better anti - fouling ability. Besides, the heat transfer efficiency can be promoted to a higher level if the objects that can disturb flow are put in the tubes. However, higher heat transfer efficiency of such enhanced heat transfer tubes can only be achieved under certain conditions. Therefore, new heat transfer tubes that could avoid the formation of mobile dead-zone should be designed to meet the broad applications or facilitate better heat transfer effect.
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6.
  • Hou, Cong wei, et al. (author)
  • Parametric analysis on throttling components of multi-stage high pressure reducing valve
  • 2018
  • In: Applied Thermal Engineering. - : Elsevier BV. - 1359-4311. ; 128, s. 1238-1248
  • Journal article (peer-reviewed)abstract
    • High pressure reducing valve (HPRV) is widely used for pressure and temperature control of heated steams in power plant and other related process engineering. The structures of throttling components inside HPRVs have important effects on the control performances. In this paper, a parametric study of throttling components in a multi-stage high pressure reducing valve (MSHPRV) is carried out, including the relative angle of inner and outer porous shrouded holes, the orifice plate thickness, the number of orifice plates and the diameter of plate holes. A numerical model is established to investigate internal flow and throttling characteristics with RNG k-ε model, and it is validated by the theoretical flux calculation. The results show that, the relative angle set as 180° can obtain the largest decompression pressure when steam flows through porous shrouded valve core, while the turbulence degree is the lowest. Setting one orifice plate can decrease the turbulent dissipation rate. The plate thickness has less influence on throttling effects. For ensuring the outlet flux, plate holes with smaller diameters should be chosen with a better flowing property on thermodynamic parameters. The work can be referred by the design work of throttling components in MSHPRV and it can also benefit the further research on similar HPRVs.
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7.
  • Jin, Zhi-jiang, et al. (author)
  • A parametric study of hydrodynamic cavitation inside globe valves
  • 2018
  • In: Journal of Fluids Engineering. - : ASME International. - 0098-2202 .- 1528-901X. ; 140:3
  • Journal article (peer-reviewed)abstract
    • Hydrodynamic cavitation that occurs inside valves not only increases the energy consumption burden of the whole piping system but also leads to severe damages to the valve body and the piping system with a large economic loss. In this paper, in order to reduce the hydrodynamic cavitation inside globe valves, effects of valve body geometrical parameters including bending radius, deviation distance, and arc curvature linked to in/ export parts on hydrodynamic cavitation are investigated by using a cavitation model. To begin with, the numerical model is compared with similar works to check its accuracy. Then, the cavitation index and the total vapor volume are predicted. The results show that vapor primarily appears around the valve seat and connecting downstream pipes. The hydrodynamic cavitation does not occur under a small inlet velocity, a large bending radius, and a large deviation distance. Cavitation intensity decreases with the increase of the bending radius, the deviation distance, and the arc curvature linked to in/export parts. This indicates that valve geometrical parameters should be chosen as large as possible, while the maximal fluid velocity should be limited. This work is of significance for hydrodynamic cavitation or globe valve design.
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8.
  • Jin, Zhi Jiang, et al. (author)
  • Cavitating flow through a micro-orifice
  • 2019
  • In: Micromachines. - : MDPI AG. - 2072-666X. ; 10:3
  • Journal article (peer-reviewed)abstract
    • Microfluidic systems have witnessed rapid development in recent years. As one of the most common structures, the micro-orifice is always included inside microfluidic systems. Hydrodynamic cavitation in the micro-orifice has been experimentally discovered and is harmful to microfluidic systems. This paper investigates cavitating flow through a micro-orifice. A rectangular micro-orifice with a l/d ratio varying from 0.25 to 4 was selected and the pressure difference between the inlet and outlet varied from 50 to 300 kPa. Results show that cavitation intensity increased with an increase in pressure difference. Decreasing exit pressure led to a decrease in cavitation number and cavitation could be prevented by increasing the exit pressure. In addition, the vapor cavity also increased with an increase in pressure difference and l/d ratio. Results also show the pressure ratio at cavitation inception was 1.8 when l/d was above 0.5 and the cavitation number almost remained constant when l/d was larger than 2. Moreover, there was an apparent difference in cavitation number depending on whether l/d was larger than 1.
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9.
  • Jin, Zhi Jiang, et al. (author)
  • Computational fluid dynamics analysis on orifice structure inside valve core of pilot-control angle globe valve
  • 2018
  • In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science. - : SAGE Publications. - 0954-4062 .- 2041-2983. ; 232:13, s. 2419-2429
  • Journal article (peer-reviewed)abstract
    • A novel pilot-control angle globe valve is proposed, and it has an obvious advantage of energy conservation during its opening and closing process. In pilot-control angle globe valve, the opening and closing forces are related to the orifice located inside the valve core. In this paper, the effects of orifice diameter are thoroughly studied under different working conditions such as valve core displacements and inlet velocities. To begin with, the numerical model is validated by comparing similar angle valves, and then the flow and loss coefficients under different orifice diameters are discussed. It is found that the effects of orifice diameter on force acting on valve core depend on valve core displacement and inlet velocity. Thus different valve core displacements and inlet velocities combined with different orifice diameters are further studied. It is also found that when the orifice diameter is larger than 12 mm, pilot-control angle globe valve cannot be used under small inlet velocity or large valve core displacement. In addition, formulas to calculate forces on valve core are proposed for further orifice design. This work can be referred in process industries especially in a piping system with orifice plates or globe valves.
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10.
  • Jin, Zhi jiang, et al. (author)
  • Effects of pitch and corrugation depth on heat transfer characteristics in six-start spirally corrugated tube
  • 2017
  • In: International Journal of Heat and Mass Transfer. - : Elsevier BV. - 0017-9310. ; 108, s. 1011-1025
  • Journal article (peer-reviewed)abstract
    • Spirally corrugated tube is one of the most important parts of coaxial heat exchangers. It can greatly improve the heat transfer efficiency of heat exchangers. Here, a novel spirally corrugated tube with six-start is proposed. However, up to now, there is little literature about the heat transfer performance and flow field of this novel six-start spirally corrugated tube. In this paper, the effects of geometric parameters (pitch p, corrugation depth e), Reynolds number Re and fluid properties on the heat transfer performances are investigated based on the validated numerical model. The results show that with the increasing of pitch p, both the heat transfer coefficient h and Nusselt number Nu decrease gradually. Meanwhile, with the increasing of corrugation depth e, both the secondary flow velocity vxy and the vorticity of longitudinal vortex increase gradually. Moreover, under the same working condition, the heat transfer performances of the six-start spirally corrugated tube are affected by both the working medium and Reynolds number. Finally, a criterion correlation for heat transfer calculation in the six-start spirally corrugated tube is proposed and validated to be reliable and suitable. This work can reveal the enhanced heat transfer mechanism of the six-start spirally corrugated tube and benefit the further research on heat transfer characteristics of multi-start spirally corrugated tube or other related devices.
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11.
  • Jin, Zhi-jiang, et al. (author)
  • Pressure Drop Analysis of Pilot-Control Globe Valve With Different Structural Parameters
  • 2017
  • In: Journal of Fluids Engineering. - : ASME International. - 0098-2202 .- 1528-901X. ; 139:9
  • Journal article (peer-reviewed)abstract
    • Pilot-control globe valve (PCGV) can use the pressure drop caused by fluid flowing through the orifice located at valve core bottom to open or close the main valve using a small pilot valve. In this paper, computational fluid dynamics (CFD) method is adopted to analyze the pressure drop before and after valve core of PCGV and minor loss of orifice under different structural parameters and inlet velocities, and the simulation results show a good agreement with the experimental results. It turns out that the valve diameters, orifice diameters, and pilot pipe diameters have great influences on the pressure drop and the loss coefficient. Moreover, an expression is proposed which can be used to calculate minor loss coefficient, then to estimate the pressure drop and driving force of a PCGV within limited conditions. This paper can be referenced as guidance for deciding the dimension of structural parameters and spring stiffness during design process of a PCGV.
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12.
  • Qian, Jin Yuan, et al. (author)
  • Effects of dimple cone angles on heat transfer and pressure drop in a dimple jacketed heat exchanger
  • 2017
  • In: Proceedings of CHT-17 ICHMT International Symposium on Advances in Computational Heat Transfer, 2017. - 9781567004618 ; , s. 2013-2020
  • Conference paper (peer-reviewed)abstract
    • A Dimple Jacket Heat Exchanger (DJHE) is designed for the Chemical Post-Processing Integrated Equipment (CPPIE) to enhance the heat transfer performance during chemical reaction, crystallization and drying processes. In this paper, a 3D model of a DJHE is established. Dynamic variation of temperature inside the DJHE is compared with experimental data to validate the accuracy of the numerical method. Then, by choosing one dimple from the whole DJHE as the research object, the effects of different dimple cone angles on heat transfer and pressure drop characteristics are analyzed with the validated method. The results show that the dimple cone angle has an obvious effect on the heat transfer and pressure drop performance. This work can reduce the uncertain design of DJHE, and it can also be referred by similar research works on dimple surfaces.
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13.
  • Qian, Jin Yuan, et al. (author)
  • Experimental and numerical analysis of spring stiffness on flow and valve core movement in pilot control globe valve
  • 2017
  • In: International Journal of Hydrogen Energy. - : Elsevier BV. - 0360-3199. ; 42:27, s. 17192-17201
  • Journal article (peer-reviewed)abstract
    • Valves are widely used for fluid flow control, not only for conventional fluid like water, gas and oil, but also for hydrogen under high pressure and so forth. Under these new conditions, the response time and energy consumption of valves are closely related to the whole performance of the piping system. Pilot-control globe valve (PCGV) is a novel quick response valve, which can utilize the pressure difference before and after the valve core to control the open/close states of the main valve. In this paper, the effects of spring stiffness inside PCGV on the flow and the valve core movement are carried out, respectively. To begin with, the experimental setup is introduces and the 3D numerical model is established. The simulation is carried out in software FLUENT with RNG k-ε turbulence model, User Defined Function method and dynamic mesh regeneration methods under transmit state. Then, a comparison of steady valve core displacements between experiment and simulation is carried out. After that, the effects of spring stiffness on flow characteristics, valve core movement and response times during opening and closing periods are presented. Finally, a spring chosen correction equation is proposed. This work can benefit the further design work of PCGVs or similar valves with springs, and it can be also referred by someone dealing with novel control valves design or flow control issues.
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14.
  • Qian, Jin yuan, et al. (author)
  • Flow rate analysis of compressible superheated steam through pressure reducing valves
  • 2017
  • In: Energy. - : Elsevier BV. - 0360-5442. ; 135, s. 650-658
  • Journal article (peer-reviewed)abstract
    • Steam flow is the main form for energy transfer in power plants, process industries, etc. The flow rate of the steam relates to the energy transfer amount directly. Pressure reducing valves are used for flow rate control of the compressible superheated steam in these piping systems. In this paper, a pressure reducing valve with a novel valve core is proposed. In order to analyze the internal flow characteristics of the compressible superheated steam and the flow rate adjustment performance of the proposed pressure reducing valve, a numerical model of DN80 pressure reducing valve is established. Then, the flow characteristics inside are studied numerically. Meanwhile, the flow rate adjustment performance is also carried out experimentally. Compared with the numerical and experimental results, it shows an agreement and both of them are similar to linear flow rate. Furthermore, a fitting equation for the flow rate prediction is carried out for the engineering applications under different working conditions.
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15.
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16.
  • Akiyama, Kazunori, et al. (author)
  • The persistent shadow of the supermassive black hole of M 87: I. Observations, calibration, imaging, and analysis*
  • 2024
  • In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 681
  • Journal article (peer-reviewed)abstract
    • In April 2019, the Event Horizon Telescope (EHT) Collaboration reported the first-ever event-horizon-scale images of a black hole, resolving the central compact radio source in the giant elliptical galaxy M 87. These images reveal a ring with a southerly brightness distribution and a diameter of ∼42 μas, consistent with the predicted size and shape of a shadow produced by the gravitationally lensed emission around a supermassive black hole. These results were obtained as part of the April 2017 EHT observation campaign, using a global very long baseline interferometric radio array operating at a wavelength of 1.3 mm. Here, we present results based on the second EHT observing campaign, taking place in April 2018 with an improved array, wider frequency coverage, and increased bandwidth. In particular, the additional baselines provided by the Greenland telescope improved the coverage of the array. Multiyear EHT observations provide independent snapshots of the horizon-scale emission, allowing us to confirm the persistence, size, and shape of the black hole shadow, and constrain the intrinsic structural variability of the accretion flow. We have confirmed the presence of an asymmetric ring structure, brighter in the southwest, with a median diameter of 43.3-3.1+1.5 μas. The diameter of the 2018 ring is remarkably consistent with the diameter obtained from the previous 2017 observations. On the other hand, the position angle of the brightness asymmetry in 2018 is shifted by about 30 relative to 2017. The perennial persistence of the ring and its diameter robustly support the interpretation that the ring is formed by lensed emission surrounding a Kerr black hole with a mass ∼6.5× 109M. The significant change in the ring brightness asymmetry implies a spin axis that is more consistent with the position angle of the large-scale jet.
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17.
  • Algaba, Juan-Carlos, et al. (author)
  • Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
  • 2021
  • In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
  • Research review (peer-reviewed)abstract
    • In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded.
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18.
  • Chen, Fu Qiang, et al. (author)
  • CFD analysis on flow characteristics of perforated plate in multi-stage high pressure reducing valve
  • 2018
  • In: Proceedings of the 3rd Thermal and Fluid Engineering Summer Conference, TFESC 2018. - 2379-1748. - 9781567004724 ; 2018-March, s. 339-351
  • Conference paper (peer-reviewed)abstract
    • Perforated plate is taken as an important throttling component to regulate pressure in a pressure reducing valve or a high pressure vessel etc., based on its special structural characteristics. To regulate pressure to a target value, a self-designed multi-stage high pressure reducing valve (MSHPRV) is proposed. It has such advantages as avoiding noise and vibration. In this paper, flow fields analysis on perforated plate in MSHPRV is conducted from three aspects based on a validated numerical model. Firstly, different stages of perforated plate are investigated to figure out the impact of stage on flow fields. Secondly, different apertures of perforated plate are studied to find its impact on flow fields. Finally, different pressure ratios are discussed, in that pressure ratio plays an important role in flow field distribution. This work can benefit the further research work on perforated plate flow investigation and multi-stage design of pressure reducing devices and so forth.
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19.
  • Chen, Fu qiang, et al. (author)
  • Pressure analysis on two-step high pressure reducing system for hydrogen fuel cell electric vehicle
  • 2017
  • In: International Journal of Hydrogen Energy. - : Elsevier BV. - 0360-3199. ; 42:16, s. 11541-11552
  • Journal article (peer-reviewed)abstract
    • Hydrogen fuel cell electric vehicle (FCEV) can achieve zero exhaust emission and zero pollution. In order to make FCEV reach a farther travel distance, greater demands are put on its pressure reducing system. In this paper, a two-step high pressure reducing system for FCEV is proposed. The system is made up of two parts, a new high multi-stage pressure reducing valve (HMSPRV) and a multi-stage muffler. As a new system, its feasibility has to be verified. Since the valve opening condition has a great effect on hydrogen flow, pressure reduction and energy consumption, different valve opening conditions are taken as the research point. The flow field analysis of the new HMSPRV is conducted on three aspects: pressure field, velocity field and energy consumption. It can be found that both the pressure reducing and velocity increasing gradients mainly reflect at those throttling components for all valve openings. For energy consumption, in the comprehensive study of flow vortexes and turbulent dissipation rate, it can be found that the larger of the valve opening, the larger of energy consumption. Then, a thermo-fluid-solid coupling analysis is conducted on the new HMSPRV, and it is concluded that the new system meets strength requirement. Furthermore, as the second step of the high pressure reducing system, the flow and pressure fields of multi-stage muffler are investigated. The five-stage muffler is exactly designed to complete the whole pressure reducing process. This study can provide technological support for achieving pressure regulation in the hydrogen transport system of FCEV when facing complex conditions, and it can also benefit the further research work on energy saving and multi-stage flow of pressure reducing devices.
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20.
  • Chen, Fu qiang, et al. (author)
  • Thermo-mechanical stress and fatigue damage analysis on multi-stage high pressure reducing valve
  • 2017
  • In: Annals of Nuclear Energy. - : Elsevier BV. - 0306-4549. ; 110, s. 753-767
  • Journal article (peer-reviewed)abstract
    • A multi-stage high pressure reducing valve (MSHPRV) is proposed. It can achieve a multi-stage pressure reducing way. Valve failure mainly occurs under high pressure and high temperature conditions, thus it is necessary to investigate the strength of MSHPRV under those complex conditions. In this paper, the mathematical model of MSHPRV is established and Computational Fluid Dynamics (CFD) method is employed to simulate its flow fields and thermo-mechanical stress. Next, the stress of MSHPRV under different opening time and the fatigue damage of MSHPRV under different valve openings are studied. Finally, two changes are provided on geometry of MSHPRV and the geometrical factors are optimized. The results show that, the radial direction from inner wall to outer wall is the main heat transfer direction for valve body. At opening time 50 s, the working condition of MSHPRV is dangerous condition. Meanwhile, the maximum value of thermal stress is 487 MPa, which is located at the upper end face of valve chamber region B3. There is a lag effect of stress distribution with respect to temperature distribution. The combined stress of valve body is composed of thermal stress and mechanical stress, in which thermal stress holds the dominant position. Moreover, with the increasing of valve opening, the fatigue damage of valve body increases correspondingly. It can be concluded that MSHPRV can cope with complex conditions like high pressure and high temperature. In the optimization design of MSHPRV, it can be found that the best strength of MSHPRV is achieved with such geometrical factors as angle 15, diameter 4 mm and 2 stage plates. Besides, radian design as the improved structure is recommended. This work can benefit the further research work on the regulation performance and safe operation of high pressure reducing valve.
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21.
  • Chen, Fu qiang, et al. (author)
  • Turbulent compressible flow analysis on multi-stage high pressure reducing valve
  • 2018
  • In: Flow Measurement and Instrumentation. - : Elsevier BV. - 0955-5986. ; 61, s. 26-37
  • Journal article (peer-reviewed)abstract
    • Pressure reducing valve plays an important role in thermodynamic systems. Under extreme operating conditions, greater demands are requested on pressure reducing systems. In this paper, a novel multi-stage high pressure reducing valve (MSHPRV) is proposed, which can achieve multi-stage pressure reducing processes, improve the flow characteristics and deal with complex conditions. Here, the effects of different structural parameters on turbulent compressible flow inside MSHPRV are numerically investigated to achieve low valve noise and energy consumption. Mach number is taken as the parameter to reflect the fluid compressibility. Higher Mach number can cause serious aerodynamic noise and large amount of energy consumption. Based on this, transmission loss of MSHPRV is also studied to achieve better noise control performances. Meanwhile, larger turbulent dissipation rate means larger degree of energy consumption, so it is with the exergy loss. Thus, numerical models with different valve openings, perforated plate diameters, chamfer radii of perforated plates, pressure ratios and stages of perforated plates are established, and the effects of these structural parameters on the compressible turbulent flow and energy consumption of MSHPRV are investigated. Results show that different structural parameters have significant impacts on compressible turbulent flow and energy consumption performance in MSHPRV. The best noise control and least energy consumption of MSHPRV is achieved with such parameters as pressure ratio 7, perforated plate diameter 4 mm and 4 stage plates. This work can benefit the further research work on energy saving and multi-stage design of pressure reducing devices.
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22.
  • Chen, Min Rui, et al. (author)
  • Effects of nanoparticles on hydraulic cavitation
  • 2018
  • In: XI International Conference on Computational Heat, Mass and Momentum Transfer (ICCHMT 2018). - : EDP Sciences. ; 240
  • Conference paper (peer-reviewed)abstract
    • When liquids flowing through a throttling element, such as a perforated plate, the velocity increases and the pressure decreases. If the pressure is below the saturated vapor pressure, the liquid will vaporize into small bubbles, which is called hydraulic cavitation. In fact, vaporization nucleus is another crucial condition for vaporizing. The nanoparticles contained in the nanofluids play a significant role in vaporization of liquids. In this paper, the effects of the nanoparticles on hydraulic cavitation are investigated. Firstly, a geometric model of a pipe channel equipped with a perforated plate is established. Then with different nanoparticle volume fractions and diameters, the nanofluids flowing through the channel is numerically simulated based on a validated numerical method. The operation conditions, such as the temperature and the pressure ratio of inlet to outlet, are the considered variables. As a significant parameter, cavitation numbers under different operation conditions are achieved to investigate the effects of nanoparticles on hydraulic cavitation. Meanwhile, the contours are extracted to research the distribution of bubbles for further investigation. This study is of interests for researchers working on hydraulic cavitation or nanofluids.
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23.
  • Chen, Min Rui, et al. (author)
  • Numerical Simulation of Droplet Generation in Cross-Junction Microchannel under Changing Dispersion Phase Velocities
  • 2018
  • In: Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities. - 1003-9015. ; 32:3, s. 522-528
  • Journal article (peer-reviewed)abstract
    • Micro-droplets with excellent physical properties and size effects are widely used in different fields. Peristaltic pumps are often used for droplet generation. The thrust force of pumps is periodic as a periodic disturbance when the time scale is short enough. Numerical simulation based on a validated model was applied to study the periodic disturbance effects on droplet generation in a cross-junction microchannel. A volume of fluid (VOF) method was adopted with the continuous phase of silicon oil and the disperse phase of water. When the velocity of the continuous and dispersed phases is both 0.01 m∙s-1, the droplet generation time is 0.08 s. Sine functions with cycles of 0.04, 0.08, 0.12 and 0.16 s and amplitudes of 0.0025, 0.005, 0.0075 and 0.01 were imported as the inlet velocity of the disperse phase. Droplet sizes and generation times were obtained by simulating different flow processes. The results show that when the cycle is less than 0.08 s, changes of cycle time and amplitude have few effects on droplet size and generation time. However, when the cycle time is larger than 0.08 s, droplet size and generation time change periodically. Furthermore, amplitude has few effects on droplet generation.
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24.
  • Chen, Min Rui, et al. (author)
  • The hydraulic cavitation affected by nanoparticles in nanofluids
  • 2018
  • In: Computation. - : MDPI AG. - 2079-3197. ; 6:3
  • Journal article (peer-reviewed)abstract
    • When liquids flow through a throttling element, the velocity increases and the pressure decreases. At this point, if the pressure is below the saturated vapor pressure of this liquid, the liquid will vaporize into small bubbles, causing hydraulic cavitation. In fact, a vaporization nucleus is another crucial condition for vaporizing, and particles contained in the liquid can also work as the vaporization nuclear. As a novel heat transfer medium, nanofluids have attracted the attention of many scholars. The nanoparticles contained in the nanofluids play a significant role in the vaporization of liquids. In this paper, the effects of the nanoparticles on hydraulic cavitation are investigated. Firstly, a geometric model of a perforated plate, the throttling element in this paper, is established. Then with different nanoparticle volume fractions and diameters, the nanofluids flowing through the perforated plate are numerically simulated based on a validated numerical method. The operation conditions, such as the ratio of inlet to outlet pressures and the temperature are the considered variables. Additionally, cavitation numbers under different operating conditions are achieved to investigate the effects of nanoparticles on hydraulic cavitation. Meanwhile, the contours are extracted to research the distribution of bubbles for further investigation. This study is of interest for researchers working on hydraulic cavitation or nanofluids.
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25.
  • Chen, Zhi, et al. (author)
  • Large-Area Crystalline Zeolitic Imidazolate Framework Thin Films
  • 2021
  • In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 60:25, s. 14124-14130
  • Journal article (peer-reviewed)abstract
    • We report that continuous MOF films with highly controlled thickness (from 44 to 5100 nm) can be deposited over length scales greater than 80 centimeters by a facile, fast, and cost-effective spray-coating method. Such success relies on our discovery of unprecedented perfectly dispersed colloidal solutions consisting of amorphous MOF nanoparticles, which we adopted as precursors that readily converted to the crystalline films upon low-temperature in situ heating. The colloidal solutions allow for the fabrication of compact and uniform MOF films on a great deal of substrates such as fluorine-doped tin oxide, glass, SiO2, Al2O3, Si, Cu, and even flexible polycarbonate, widening their technological applications where substrates are essential. Despite the present work focuses on the fabrication of uniform cobalt-(2-methylimidazole)2 and zinc-(2-methylimidazole)2 films, our findings mark a great possibility in producing other high-quality MOF thin films on a large scale.
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26.
  • Jin, Zhi jiang, et al. (author)
  • Thermodynamic analysis of siphon flash evaporation desalination system using ocean thermal energy
  • 2017
  • In: Energy Conversion and Management. - : Elsevier BV. - 0196-8904. ; 136, s. 66-77
  • Journal article (peer-reviewed)abstract
    • Ocean thermal energy refers to the thermal potential energy produced by the temperature difference between the warm surface seawater and the cold deep seawater. In this paper, a siphon flash evaporation desalination system using ocean thermal energy is proposed. Because it can utilize the ocean thermal energy directly for desalination, siphon flash evaporation desalination system has relatively higher energy efficiency compared with converting ocean thermal energy into electric energy and then using electric energy for desalination. The working principle of this system is introduced firstly. Then, the exergy, exergy loss and exergy efficiency in the flash evaporation, condensation and the whole system are carried out quantitatively. The results show that the exergy efficiency of the system which directly utilizing ocean thermal energy for desalination reaches to 7.81% under design conditions; lower surface seawater temperature, higher deep seawater temperature and higher flash temperature can result in an increasing of system efficiency, while the whole energy consumption shall also be taken into consideration. Then the simulation model of the whole system is created in ASPEN PLUS in order to investigate the influence of some most important parameters, such as surface seawater temperatures, deep seawater temperatures and difference of inlet temperature between surface and deep seawater. Finally, an experimental platform is established based on the working principle and process to verify the validity of the working principle and the simulation model. The siphon flash evaporation desalination system provides a novel method of direct high efficient conversion and utilization of ocean thermal energy and this work can provide the theoretical support for the feasibility of similar engineering applications.
  •  
27.
  • Li, Xiao Juan, et al. (author)
  • Research progress of frost formation on microchannel heat exchangers
  • 2017
  • In: Xiandai Huagong/Modern Chemical Industry. - 0253-4320. ; 37:11, s. 47-52
  • Research review (peer-reviewed)abstract
    • Focusing on the frost formation in microchannel heat exchangers, this paper analyzes the effects of frost formation on the thermal performance of microchannel heat exchangers, and summarizes the influence factors that cause the microchannel heat exchangers to form frost, including environmental factors and structure factors. The latest research progress in this issue at home and abroad is reviewed.
  •  
28.
  • Pecunia, Vincenzo, et al. (author)
  • Roadmap on energy harvesting materials
  • 2023
  • In: Journal of Physics. - : IOP Publishing. - 2515-7639. ; 6:4
  • Journal article (peer-reviewed)abstract
    • Ambient energy harvesting has great potential to contribute to sustainable development and address growing environmental challenges. Converting waste energy from energy-intensive processes and systems (e.g. combustion engines and furnaces) is crucial to reducing their environmental impact and achieving net-zero emissions. Compact energy harvesters will also be key to powering the exponentially growing smart devices ecosystem that is part of the Internet of Things, thus enabling futuristic applications that can improve our quality of life (e.g. smart homes, smart cities, smart manufacturing, and smart healthcare). To achieve these goals, innovative materials are needed to efficiently convert ambient energy into electricity through various physical mechanisms, such as the photovoltaic effect, thermoelectricity, piezoelectricity, triboelectricity, and radiofrequency wireless power transfer. By bringing together the perspectives of experts in various types of energy harvesting materials, this Roadmap provides extensive insights into recent advances and present challenges in the field. Additionally, the Roadmap analyses the key performance metrics of these technologies in relation to their ultimate energy conversion limits. Building on these insights, the Roadmap outlines promising directions for future research to fully harness the potential of energy harvesting materials for green energy anytime, anywhere.
  •  
29.
  • Qian, Jin yuan, et al. (author)
  • A comprehensive review on liquid–liquid two-phase flow in microchannel : flow pattern and mass transfer
  • 2019
  • In: Microfluidics and Nanofluidics. - : Springer Science and Business Media LLC. - 1613-4982 .- 1613-4990. ; 23:10
  • Research review (peer-reviewed)abstract
    • Liquid–liquid two-phase flow in microchannel is very common in micro-chemical and micro-biological system, etc. Deep understanding of the liquid–liquid two-phase flow mechanisms and mass transfer in microchannel can promote industrial applications significantly. To summarize the recent research progress on the liquid–liquid two-phase flow in microchannel, this paper collects research work about this topic, especially focusing on flow pattern and mass transfer. To begin with, flow patterns observed in various conditions are identified and factors which influence the flow patterns are analyzed. Then, mass transfer in liquid–liquid two-phase flow is discussed, especially the mass transfer during droplet flow, with both experiments and simulations. Furthermore, energy dissipation involved in liquid–liquid two-phase flow in microchannel is also briefly discussed. Finally, future needs are proposed for extending the researches on liquid–liquid two-phase flow and enlarging its application fields.
  •  
30.
  • Qian, Jin Yuan, et al. (author)
  • A geometric study on shell side heat transfer and flow resistance of a six-start spirally corrugated tube
  • 2018
  • In: Numerical Heat Transfer; Part A: Applications. - : Informa UK Limited. - 1040-7782 .- 1521-0634. ; 73:8, s. 565-582
  • Journal article (peer-reviewed)abstract
    • Heat transfer enhancement is of great importance for energy efficiency improvement. The utilization of spirally corrugated tubes is one of the efficient ways to strengthen heat transfer. In this article, based on a validated numerical model, the effects of geometric parameters of a six-start spirally corrugated tube, including the pitch p and the corrugation depth e, on the shell side heat transfer and flow resistance performance are numerically investigated, in high Reynolds number conditions ranging from 10,000 to 60,000. The shell side secondary flow velocity distribution, longitudinal vortex distribution, and temperature distribution of a six-start spirally corrugated tube are presented, respectively. In addition, the heat transfer and flow resistance characteristics are evaluated by comparing the Nusselt number and the flow resistance coefficient with these of smooth tubes. Results show that the utilization of six-start spirally corrugated tubes can enhance the heat transfer performance at the expense of an increase of the flow resistance. However, with the same geometric parameters, the Nusselt number increases and the flow resistance coefficient decreases as Reynolds number increases. With the pitch increasing, the Nusselt number and the flow resistance coefficient decrease at a fixed Reynolds number. In contrast, as the corrugation depth increasing, the Nusselt number changes irregularly, and the flow resistance coefficient increases. Finally, correlations for the shell side Nusselt number and flow resistance coefficient of the six-start spirally corrugated tube are established. This work is of significance for engineers and scientists focusing on the heat transfer and the flow resistance characteristics of spirally corrugated tubes and their applications.
  •  
31.
  • Qian, Jin yuan, et al. (author)
  • A numerical study of heat transfer effects and aerodynamic noise reduction in superheated steam flow passing a temperature and pressure regulation valve
  • 2020
  • In: Numerical Heat Transfer; Part A: Applications. - : Informa UK Limited. - 1040-7782 .- 1521-0634. ; 77:10, s. 873-889
  • Journal article (peer-reviewed)abstract
    • Steam is a common medium in thermal engineering. When it flows through a throttling element, the aerodynamic noise may occur due to the disturbance. In this investigation, superheated steam flowing through a Venturi tube, one of the main parts in a temperature and pressure regulation valve, at different thermal conditions is studied to analyze to effects of heat transfer on the acoustic power. With a high temperature and a low pressure, the superheated steam is treated as ideal gas. The flow velocity is high, so the k-epsilon turbulent model is used, with the compressible steam. The results show that under the adiabatic condition, the acoustic power mainly influenced by the turbulent characteristics, such as the dissipation rate and the turbulent kinetic energy. Comparing the acoustic power levels at different thermal conditions, it is found that a lower temperature results to a lower acoustic power.
  •  
32.
  • Qian, Jin yuan, et al. (author)
  • Analysis of Fouling in Six-Start Spirally Corrugated Tubes
  • 2020
  • In: Heat Transfer Engineering. - : Informa UK Limited. - 0145-7632 .- 1521-0537. ; 41, s. 1885-1900
  • Journal article (peer-reviewed)abstract
    • Fouling on heat exchanger surfaces can weaken the heat-transfer capability, increase the energy consumption, and even cause the failure of the whole system. In coaxial heat exchangers, spirally corrugated tubes perform better than smooth ones concerning heat transfer and antifouling. In this article, a parametric study on the antifouling performance of a six-start spirally corrugated tube is carried out with a solid–liquid two-phase model. First, comparisons between a smooth tube and a specific sample six-start spirally corrugated tube on the solid particle volume fraction distributions are carried out. Then, the effects of solid particle diameter, the main geometric parameters, including pitch and the corrugation depth, are investigated. Analyzing the solid particle volume fraction with different geometries, solid particle diameters and Reynolds number, the roles played by the centrifugal force, drag force, and gravity of solid particles on fouling performance in six-start spirally corrugated tubes are obtained. In addition, the corrugation depth affects the volume fraction range more while the pitch affects more on the steady range of particle volume fraction. This work is of significance for further design of spirally corrugated tubes and analysis of fouling problems in heat exchangers.
  •  
33.
  • Qian, Jin Yuan, et al. (author)
  • Effects of a dynamic injection flow rate on slug generation in a cross-junction square microchannel
  • 2019
  • In: Processes. - : MDPI AG. - 2227-9717. ; 7:10
  • Journal article (peer-reviewed)abstract
    • The injection flow rates of two liquid phases play a decisive role in the slug generation of the liquid-liquid slug flow. However, most injection flow rates so far have been constant. In order to investigate the effects of dynamic injection flow rates on the slug generation, including the slug size, separation distance and slug generation cycle time, a transient numerical model of a cross-junction square microchannel is established. The Volume of Fluid method is adopted to simulate the interface between two phases, i.e., butanol and water. The model is validated by experiments at a constant injection flow rate. Three different types of dynamic injection flow rates are applied for butanol, which are triangle, rectangular and sine wave flow rates. The dynamic injection flow rate cycles, which are related to the constant slug generation cycle time t0, are investigated. Results show that when the cycle of the disperse phase flow rate is larger than t0, the slug generation changes periodically, and the period is influenced by the cycle of the disperse phase flow rate. Among the three kinds of dynamic disperse flow rate, the rectangular wave influences the slug size most significantly, while the triangle wave influences the separation distance and the slug generation time more prominently.
  •  
34.
  • Qian, Jin-Yuan, et al. (author)
  • Effects of orifice on pressure difference in pilot-control globe valve by experimental and numerical methods
  • 2016
  • In: International Journal of Hydrogen Energy. - : Elsevier BV. - 1879-3487 .- 0360-3199. ; 41:41, s. 18562-18570
  • Journal article (peer-reviewed)abstract
    • Pilot-Control Globe Valve (PCGV) can utilize pressure difference caused by fluid flow through the orifice on valve core as its power, for open and close the main valve with a small pilot valve. It has obvious advantages of energy conservation and quick response. Orifice structure on the valve core is the main component to determine the pressure difference, which is used to push the valve core. In this paper, the numerical model with User Defined Functions (UDFs) method is carried out, and the experimental device is arranged. The numerical and experimental results of valve core displacements achieve agreements. Then, analysis of pressure difference under different static pressures, inlet velocities and different orifice diameters are carried out. It shows that pressure difference has no relationship with static pressure, thus PCGV can be adopted in hydrogen pipelines. Meanwhile, higher inlet velocity can turn out larger pressure difference with quicker response of PCGV. In addition, there exits an unbalanced moment, and 15 mm is the extreme diameter of the orifice for DN150 PCGV. Finally, the design method of the orifice structure in PCGV is proposed with design formulas. This work can help the precise design work of PCGV, and it can be referred by other researchers who are also deal with orifice structures in similar valves design work.
  •  
35.
  • Qian, Jin Yuan, et al. (author)
  • Obstacle contained system (OCS) design method and its application in valve core orifice design of pilot-control globe valve
  • 2017
  • In: Chinese Journal of Engineering Design. - 1006-754X. ; 24:5, s. 496-502
  • Journal article (peer-reviewed)abstract
    • With the development of the society and the times, traditional parametric design methods are witnessing a severe challenge due to the more and more complex physical systems. Thus, developing novel parametric analysis methods is very important for dealing with complex physical systems, refining useful parameters from numerous data, and proposing accurate prediction formulas. A spring slider system, a direct-current circuit system, a pipeline pressure drop system and a steady heat transfer model of flat plate system were described from the point of systemic parametric analysis method. Then, the key physical parameters in above four systems were summarized. Based on the comparative results, a novel systemic parametric design method, obstacle contained system (OCS) design method, was proposed. The OCS was made up of three elements:an obstacle element, a pass body element and a D-value element. With an abundant accurate data pole, the OCS design method could build the direct relationship of the obstacle element and the D-value element, which meant the simplification of the physical models and much easier to get relatively accurate results. Meanwhile, the design of pilot-control globe valve orifice was checked with both the OCS design method and the numerical simulation. The diameter of orifice on the valve core could influence the pressure difference and the maximum vapor rate inside pilot-control globe valves. Achieved by two different methods, the OCS design method and the numerical simulation, the results showed that the effects of orifice diameters on the pressure difference and the maximum vapor rate under different inlet velocities, were within 2% errors, which was reasonable and acceptable for the engineering application. In other words, the OCS design method was credible for parametric analysis. In future, the OCS design method has a broad application prospect to analyze various types of physical models especially in the era of big data.
  •  
36.
  • Yang, Chen, et al. (author)
  • Heat transfer study on a hybrid smooth and spirally corrugated tube
  • 2018
  • In: XI International Conference on Computational Heat, Mass and Momentum Transfer (ICCHMT 2018). - : EDP Sciences. ; 240
  • Conference paper (peer-reviewed)abstract
    • Corrugated tubes are widely used in a range of applications for heat transfer enhancement. The spirally corrugated tube has a better heat transfer performance than the smooth tube. In this paper, the heat transfer performance of a hybrid smooth and six-start spirally corrugated tube is studied. With a validated numerical model, the effects of the corrugation part length on the vortex in the downstream smooth tube are studied for a range of high Reynolds numbers, where the existence of the corrugation part can turn out the secondary flow and enhance heat transfer. Meanwhile, it is found that in the smooth part, the fluid flow part with whirling can reach a maximum length, even if the length of the corrugation part continuously increases. Thus a series of critical corrugation lengths can be obtained. This work can reveal the enhanced heat transfer mechanism of the hybrid smooth and spirally corrugated tube and be of interest to researchers in heat transfer issues of corrugated tubes.
  •  
37.
  • Akiyama, Kazunori, et al. (author)
  • First M87 Event Horizon Telescope Results. IX. Detection of Near-horizon Circular Polarization
  • 2023
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 957:2
  • Journal article (peer-reviewed)abstract
    • Event Horizon Telescope (EHT) observations have revealed a bright ring of emission around the supermassive black hole at the center of the M87 galaxy. EHT images in linear polarization have further identified a coherent spiral pattern around the black hole, produced from ordered magnetic fields threading the emitting plasma. Here we present the first analysis of circular polarization using EHT data, acquired in 2017, which can potentially provide additional insights into the magnetic fields and plasma composition near the black hole. Interferometric closure quantities provide convincing evidence for the presence of circularly polarized emission on event-horizon scales. We produce images of the circular polarization using both traditional and newly developed methods. All methods find a moderate level of resolved circular polarization across the image (〈|v|〉 < 3.7%), consistent with the low image-integrated circular polarization fraction measured by the Atacama Large Millimeter/submillimeter Array (|vint| < 1%). Despite this broad agreement, the methods show substantial variation in the morphology of the circularly polarized emission, indicating that our conclusions are strongly dependent on the imaging assumptions because of the limited baseline coverage, uncertain telescope gain calibration, and weakly polarized signal. We include this upper limit in an updated comparison to general relativistic magnetohydrodynamic simulation models. This analysis reinforces the previously reported preference for magnetically arrested accretion flow models. We find that most simulations naturally produce a low level of circular polarization consistent with our upper limit and that Faraday conversion is likely the dominant production mechanism for circular polarization at 230 GHz in M87*
  •  
38.
  • Akiyama, Kazunori, et al. (author)
  • First Sagittarius A∗ Event Horizon Telescope Results. VII. Polarization of the Ring
  • 2024
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 964:2
  • Journal article (peer-reviewed)abstract
    • The Event Horizon Telescope observed the horizon-scale synchrotron emission region around the Galactic center supermassive black hole, Sagittarius A∗ (Sgr A∗), in 2017. These observations revealed a bright, thick ring morphology with a diameter of 51.8 ± 2.3 μas and modest azimuthal brightness asymmetry, consistent with the expected appearance of a black hole with mass M≈ 4 × 106 M⊙. From these observations, we present the first resolved linear and circular polarimetric images of Sgr A∗. The linear polarization images demonstrate that the emission ring is highly polarized, exhibiting a prominent spiral electric vector polarization angle pattern with a peak fractional polarization of ∼40% in the western portion of the ring. The circular polarization images feature a modestly (∼5%°-10%) polarized dipole structure along the emission ring, with negative circular polarization in the western region and positive circular polarization in the eastern region, although our methods exhibit stronger disagreement than for linear polarization. We analyze the data using multiple independent imaging and modeling methods, each of which is validated using a standardized suite of synthetic data sets. While the detailed spatial distribution of the linear polarization along the ring remains uncertain owing to the intrinsic variability of the source, the spiraling polarization structure is robust to methodological choices. The degree and orientation of the linear polarization provide stringent constraints for the black hole and its surrounding magnetic fields, which we discuss in an accompanying publication.
  •  
39.
  • Akiyama, Kazunori, et al. (author)
  • First Sagittarius A∗ Event Horizon Telescope Results. VIII. Physical Interpretation of the Polarized Ring
  • 2024
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 964:2
  • Journal article (peer-reviewed)abstract
    • In a companion paper, we present the first spatially resolved polarized image of Sagittarius A∗ on event horizon scales, captured using the Event Horizon Telescope, a global very long baseline interferometric array operating at a wavelength of 1.3 mm. Here we interpret this image using both simple analytic models and numerical general relativistic magnetohydrodynamic (GRMHD) simulations. The large spatially resolved linear polarization fraction (24%-28%, peaking at ∼40%) is the most stringent constraint on parameter space, disfavoring models that are too Faraday depolarized. Similar to our studies of M87∗, polarimetric constraints reinforce a preference for GRMHD models with dynamically important magnetic fields. Although the spiral morphology of the polarization pattern is known to constrain the spin and inclination angle, the time-variable rotation measure (RM) of Sgr A∗ (equivalent to ≈ 46° ± 12° rotation at 228 GHz) limits its present utility as a constraint. If we attribute the RM to internal Faraday rotation, then the motion of accreting material is inferred to be counterclockwise, contrary to inferences based on historical polarized flares, and no model satisfies all polarimetric and total intensity constraints. On the other hand, if we attribute the mean RM to an external Faraday screen, then the motion of accreting material is inferred to be clockwise, and one model passes all applied total intensity and polarimetric constraints: a model with strong magnetic fields, a spin parameter of 0.94, and an inclination of 150°. We discuss how future 345 GHz and dynamical imaging will mitigate our present uncertainties and provide additional constraints on the black hole and its accretion flow.
  •  
40.
  • Feigin, Valery L., et al. (author)
  • Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
  • 2021
  • In: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
  • Journal article (peer-reviewed)abstract
    • Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
  •  
41.
  • Georgiev, Boris, et al. (author)
  • A Universal Power-law Prescription for Variability from Synthetic Images of Black Hole Accretion Flows
  • 2022
  • In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 930:2
  • Journal article (peer-reviewed)abstract
    • We present a framework for characterizing the spatiotemporal power spectrum of the variability expected from the horizon-scale emission structure around supermassive black holes, and we apply this framework to a library of general relativistic magnetohydrodynamic (GRMHD) simulations and associated general relativistic ray-traced images relevant for Event Horizon Telescope (EHT) observations of Sgr A*. We find that the variability power spectrum is generically a red-noise process in both the temporal and spatial dimensions, with the peak in power occurring on the longest timescales and largest spatial scales. When both the time-averaged source structure and the spatially integrated light-curve variability are removed, the residual power spectrum exhibits a universal broken power-law behavior. On small spatial frequencies, the residual power spectrum rises as the square of the spatial frequency and is proportional to the variance in the centroid of emission. Beyond some peak in variability power, the residual power spectrum falls as that of the time-averaged source structure, which is similar across simulations; this behavior can be naturally explained if the variability arises from a multiplicative random field that has a steeper high-frequency power-law index than that of the time-averaged source structure. We briefly explore the ability of power spectral variability studies to constrain physical parameters relevant for the GRMHD simulations, which can be scaled to provide predictions for black holes in a range of systems in the optically thin regime. We present specific expectations for the behavior of the M87* and Sgr A* accretion flows as observed by the EHT.
  •  
42.
  • Gu, Shi-Ran, et al. (author)
  • Phylogeny and re-circumscription of Cheniella (Leguminosae: Cercidoideae) based on plastome data and morphology, with description of three new species
  • 2024
  • In: TAXON. - 0040-0262 .- 1996-8175. ; 73:2, s. 475-502
  • Journal article (peer-reviewed)abstract
    • Subfamily Cercidoideae is an early-diverging lineage of Leguminosae, within which the number and classification of genera have been controversial. Cheniella is a recently described genus in the Cercidoideae which requires revision and testing of its monophyly and circumscription. Here we infer the phylogenetic position and infrageneric relationships of Cheniella as well as the intergeneric relationships of Cercidoideae using 48 newly sequenced plastid genomes, including 34 individuals representing all species of Cheniella. Our phylogenetic analyses yield a well-resolved tree of Cercidoideae with robust support at most nodes. We also present morphological studies through field work and herbarium studies to re-assess the classification and circumscription of the genus. Based on the results of molecular analyses and morphological studies combined with distribution data, we broaden the circumscription of Cheniella to comprise a total of 15 species and 3 subspecies, including three new species (C. hechiensis, C. longistaminea, C. pubicarpa), one new combination (C. tianlinensis) and one new status and combination (C. longipes).
  •  
43.
  • Janssen, Michael, et al. (author)
  • Event Horizon Telescope observations of the jet launching and collimation in Centaurus A
  • 2021
  • In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 5:10, s. 1017-1028
  • Journal article (peer-reviewed)abstract
    • Very-long-baseline interferometry (VLBI) observations of active galactic nuclei at millimetre wavelengths have the power to reveal the launching and initial collimation region of extragalactic radio jets, down to 10–100 gravitational radii (rg ≡ GM/c2) scales in nearby sources1. Centaurus A is the closest radio-loud source to Earth2. It bridges the gap in mass and accretion rate between the supermassive black holes (SMBHs) in Messier 87 and our Galactic Centre. A large southern declination of −43° has, however, prevented VLBI imaging of Centaurus A below a wavelength of 1 cm thus far. Here we show the millimetre VLBI image of the source, which we obtained with the Event Horizon Telescope at 228 GHz. Compared with previous observations3, we image the jet of Centaurus A at a tenfold higher frequency and sixteen times sharper resolution and thereby probe sub-lightday structures. We reveal a highly collimated, asymmetrically edge-brightened jet as well as the fainter counterjet. We find that the source structure of Centaurus A resembles the jet in Messier 87 on ~500 rg scales remarkably well. Furthermore, we identify the location of Centaurus A’s SMBH with respect to its resolved jet core at a wavelength of 1.3 mm and conclude that the source’s event horizon shadow4 should be visible at terahertz frequencies. This location further supports the universal scale invariance of black holes over a wide range of masses5,6.
  •  
44.
  • Liu, Jun, et al. (author)
  • Electrically driven ionic transport in the RCM and RIM: Investigations based on experiments and numerical simulations
  • 2022
  • In: Construction and Building Materials. - : Elsevier BV. - 0950-0618. ; 331
  • Journal article (peer-reviewed)abstract
    • In this work, the rapid chloride migration test (RCM) and the rapid iodide migration test (RIM) were utilized to investigate ionic transport in concrete with the aid of an externally applied electric field. Unlike most existing work, this study establishes computational models of ionic transport in chloride-contaminated and chloride-free concrete. The model is validated by the consistency between the numerical and experimental chloride profiles. It is found that the chloride migration depth in the RCM test is obviously affected, and the results for chloride-contaminated concrete are 50% larger compared with those for chloride-free concrete. However, the difference between the two kinds of concretes is only 5% when measured using the RIM test. Thus, the results of the RIM test are more accurate and provide a better choice for applications to characterization of chloride-contaminated concrete.
  •  
45.
  • Liu, Jun, et al. (author)
  • Numerical model of the effect of water vapor environment on the chloride transport in concrete
  • 2021
  • In: Construction and Building Materials. - : Elsevier BV. - 0950-0618. ; 311
  • Journal article (peer-reviewed)abstract
    • Chloride ions are known as one of the most crucial factors for rebar corrosion in reinforced concrete (RC) structures exposed to marine environments under drying-wetting cycles. In this condition, the chloride ion content in unsaturated concrete will change under the coupled effect of diffusion and capillary suction. This study simulates the atmosphere zone of the marine environment to explore the law of the chloride transmission behavior under the context of constant temperature and humidity. To analyze the effect of different drying-wetting ratios on the chloride ion profile in the concrete by conducting the dry-wet cycle tests. It is found that the most unfavorable drying-wetting ratios for RC structures in this study is 1:5.5. A finite element numerical model of chloride ion transmission based on Fick's Ⅱ law was established by COMSOL Multiphysics. It can be used to predict the range of concrete surface chloride ion concentration, and dynamic change of the distribution of chloride ion concentration inside the RC structures under different drying-wetting cycles over time. The comparison of experiment data and simulation results verify that the chloride diffusion prediction model has a good correlation.
  •  
46.
  • Micah, Angela E., et al. (author)
  • Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
  • 2021
  • In: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
  • Research review (peer-reviewed)abstract
    • Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
  •  
47.
  • Qian, Jy, et al. (author)
  • Heat transfer analysis on dimple geometries and arrangements in dimple jacketed heat exchanger
  • 2019
  • In: International Journal of Numerical Methods for Heat and Fluid Flow. - 0961-5539. ; 29:8, s. 2775-2791
  • Journal article (peer-reviewed)abstract
    • Purpose: The purpose of this paper is to study the effects of dimple geometries and arrangements on the heat transfer enhancement in a dimple jacketed heat exchanger. Design/methodology/approach: For the purpose of this paper, with the experimental validated numerical model, this paper carries out numerical simulations of both single dimples with different geometries and the whole dimple jacketed heat exchanger with different dimple arrangements. For a single dimple, its secondary vortex flow, temperature differences and the pressure drop performance for different geometries are analyzed. For the whole dimple jacketed heat exchanger, the heat transfer and pressure drop performances are investigated by comparing the no dimple, triangular and rectangular dimple arrangements. Findings: Results show that dimples can improve the heat transfer efficiency compared with conventional jacketed heat exchanger, and specific geometries and arrangement of dimples for better heat transfer performance are figured out. Originality/value: This paper considers both dimple geometries and arrangements, which can be useful for further applications in specific integrated devices or similar applications.
  •  
48.
  • Roelofs, F., et al. (author)
  • Polarimetric Geometric Modeling for mm-VLBI Observations of Black Holes
  • 2023
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 957:2
  • Journal article (peer-reviewed)abstract
    • The Event Horizon Telescope (EHT) is a millimeter very long baseline interferometry (VLBI) array that has imaged the apparent shadows of the supermassive black holes M87* and Sagittarius A*. Polarimetric data from these observations contain a wealth of information on the black hole and accretion flow properties. In this work, we develop polarimetric geometric modeling methods for mm-VLBI data, focusing on approaches that fit data products with differing degrees of invariance to broad classes of calibration errors. We establish a fitting procedure using a polarimetric “m-ring” model to approximate the image structure near a black hole. By fitting this model to synthetic EHT data from general relativistic magnetohydrodynamic models, we show that the linear and circular polarization structure can be successfully approximated with relatively few model parameters. We then fit this model to EHT observations of M87* taken in 2017. In total intensity and linear polarization, the m-ring fits are consistent with previous results from imaging methods. In circular polarization, the m-ring fits indicate the presence of event-horizon-scale circular polarization structure, with a persistent dipolar asymmetry and orientation across several days. The same structure was recovered independently of observing band, used data products, and model assumptions. Despite this broad agreement, imaging methods do not produce similarly consistent results. Our circular polarization results, which imposed additional assumptions on the source structure, should thus be interpreted with some caution. Polarimetric geometric modeling provides a useful and powerful method to constrain the properties of horizon-scale polarized emission, particularly for sparse arrays like the EHT.
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49.
  • Sepanlou, Sadaf G., et al. (author)
  • The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017
  • 2020
  • In: The Lancet Gastroenterology & Hepatology. - 2468-1253. ; 5:3, s. 245-266
  • Journal article (peer-reviewed)abstract
    • Background Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. Methods We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries. Findings In 2017, cirrhosis caused more than 1.32 million (95% UI 1.27-1.45) deaths (440000 [416 000-518 000; 33.3%] in females and 883 000 [838 000-967 000; 66.7%] in males) globally, compared with less than 899 000 (829 000-948 000) deaths in 1990. Deaths due to cirrhosis constituted 2.4% (2.3-2.6) of total deaths globally in 2017 compared with 1.9% (1.8-2.0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21.0 (19.2-22.3) per 100 000 population in 1990 to 16.5 (15.8-18-1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions for all years of the study period (32.2 [25.8-38.6] deaths per 100 000 population in 2017), and the high-income super-region had the lowest (10.1 [9.8-10-5] deaths per 100 000 population in 2017). The age-standardised death rate decreased or remained constant from 1990 to 2017 in all GBD regions except eastern Europe and central Asia, where the age-standardised death rate increased, primarily due to increases in alcohol-related liver disease prevalence. At the national level, the age-standardised death rate of cirrhosis was lowest in Singapore in 2017 (3.7 [3.3-4.0] per 100 000 in 2017) and highest in Egypt in all years since 1990 (103.3 [64.4-133.4] per 100 000 in 2017). There were 10.6 million (10.3-10.9) prevalent cases of decompensated cirrhosis and 112 million (107-119) prevalent cases of compensated cirrhosis globally in 2017. There was a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017. Cirrhosis caused by NASH had a steady age-standardised death rate throughout the study period, whereas the other four causes showed declines in age-standardised death rate. The age-standardised prevalence of compensated and decompensated cirrhosis due to NASH increased more than for any other cause of cirrhosis (by 33.2% for compensated cirrhosis and 54.8% for decompensated cirrhosis) over the study period. From 1990 to 2017, the number of prevalent cases snore than doubled for compensated cirrhosis due to NASH and more than tripled for decompensated cirrhosis due to NASH. In 2017, age-standardised death and DALY rates were lower among countries and territories with higher SDI. Interpretation Cirrhosis imposes a substantial health burden on many countries and this burden has increased at the global level since 1990, partly due to population growth and ageing. Although the age-standardised death and DALY rates of cirrhosis decreased from 1990 to 2017, numbers of deaths and DALYs and the proportion of all global deaths due to cirrhosis increased. Despite the availability of effective interventions for the prevention and treatment of hepatitis B and C, they were still the main causes of cirrhosis burden worldwide, particularly in low-income countries. The impact of hepatitis B and C is expected to be attenuated and overtaken by that of NASH in the near future. Cost-effective interventions are required to continue the prevention and treatment of viral hepatitis, and to achieve early diagnosis and prevention of cirrhosis due to alcohol-related liver disease and NASH.
  •  
50.
  • Abbafati, Cristiana, et al. (author)
  • 2020
  • Journal article (peer-reviewed)
  •  
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