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| 2. |
- Andersen, M. S., et al.
(författare)
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To facilitate a fair bioeconomy transition, stronger regional-level linkages are needed
- 2022
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Ingår i: Biofuels Bioproducts & Biorefining-Biofpr. - : Wiley. - 1932-104X .- 1932-1031. ; 16:4, s. 929-941
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Tidskriftsartikel (refereegranskat)abstract
- The great hopes in Brussels that a circular bioeconomy will help bridge the growing divide between urban and rural areas and allow the hinterlands to prosper from 'green growth' are addressed in this article, which reflects on insights from three Nordic case studies of brown, green and blue biomass use at different levels of technology readiness. A closer examination of the forward, backward, fiscal and final demand linkages at regional level from increased biomass utilization, from eastern Finland and northern Sweden to Jutland and North Atlantic islands, suggests that linkages are and will remain relatively weak, predominantly dashing the expectations. As suppliers and exporters of natural resources, disadvantaged regions may all too easily get locked into a 'staples trap', where the value creation evaporates owing in part to the steep start-up costs and the associated boom-and-bust cycles, which place them in a weak position vis-a-vis the resource manufacturers and consumers. To make the prospects of development, employment and prosperity in the hinterlands materialize, measures are needed to strengthen the regional-level economic linkages. Regional-level revolving funds based on benefit-sharing instruments related to natural resources can be used to bolster economic development, as reflected in such schemes present in both China and Canada. We call for further research into whether and how such approaches can be replicated successfully by channeling revenues from biomass cultivation to regional-scale revolving funds, with mandates to strengthen long-term economic linkages and prosperity within the hinterlands. (c) 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd
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| 6. |
- Fuchs, Stefanie, et al.
(författare)
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In-Line Analysis of Organ-on-Chip Systems with Sensors : Integration, Fabrication, Challenges, and Potential
- 2021
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 7:7, s. 2926-2948
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Forskningsöversikt (refereegranskat)abstract
- Organ-on-chip systems are promising new in vitro research tools in medical, pharmaceutical, and biological research. Their main benefit, compared to standard cell culture platforms, lies in the improved in vivo resemblance of the cell culture environment. A critical aspect of these systems is the ability to monitor both the cell culture conditions and biological responses of the cultured cells, such as proliferation and differentiation rates, release of signaling molecules, and metabolic activity. Today, this is mostly done using microscopy techniques and off-chip analytical techniques and assays. Integrating in situ analysis methods on-chip enables improved time resolution, continuous measurements, and a faster read-out; hence, more information can be obtained from the developed organ and disease models. Integrated electrical, electrochemical, and optical sensors have been developed and used for chemical analysis in lab-on-a-chip systems for many years, and recently some of these sensing principles have started to find use in organ-on-chip systems as well. This perspective review describes the basic sensing principles, sensor fabrication, and sensor integration in organ-on-chip systems. The review also presents the current state of the art of integrated sensors and discusses future potential. We bring a technological perspective, with the aim of introducing in-line sensing and its promise to advance organ-on-chip systems and the challenges that lie in the integration to researchers without expertise in sensor technology.
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| 9. |
- Jägerbrand, Annika K., et al.
(författare)
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Uppdatering och nya effektsamband i effektmodellen för viltolyckor
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Viltolyckor i Sverige är ett växande problem som leder till dödade och skadade personer, liksom skador på fordon och dödade djur. Viltolyckor har samhällsekonomiska kostnader som behöver kvantifieras för att man ska kunna räkna ut kostnadsnyttan av åtgärder som förebygger viltolyckor, såsom exempelvis viltstängsel eller passager. Effektmodellen för viltolyckor utvecklades under 1980-talet och ingår i EVA (effekter vid väganalyser) men är idag till vissa delar föråldrad på grund av utvecklingen som skett avseende trafiksäkerhet, viltolyckssammansättning, datasystem, kunskap och forskning. Den existerande effektmodellen bygger på risk för viltolyckor per km väg per län i tre trafikflödesklasser för älg och summerat ihop för rådjur/ren. Detta projekt har haft som mål att uppdatera effektmodellen för viltolyckor genom att inkludera aktuella data på viltolycksfördelningar och mörkertal, beakta flera viltslag (älg, rådjur, hjort och vildsvin) och involvera flera variabler som kan vara av betydelse för olyckorna: t.ex. viltets populationsstorlek, vägstandard, trafikarbete, hastighet, viltstängsel, landskapstyp och viltets populationsstorlek. Arbetet har delats upp i tre huvudsakliga delar. Den första delen omfattade att ta fram ny kunskap om sambanden mellan viltolyckor, trafikarbete, och viltpopulationer där också landskapsvariabler ingår samt kostnadsberäkningar baserat på olika typer av prognoser på längre sikt. En annan del omfattade att ta fram ny viltolycksstatistik baserat på GIS-analyser för uppdaterade effektsamband för viltolyckor (olycksfrekvens per km väg), ÅDT1 , vägstandard och stängsel samt nya skattningar av mörkertal. Den tredje delen omfattade att ta fram nya värden för skadeföljd och skadekonsekvenser för olika viltslag för 2010–2016. Resultaten från första delen av projektet visar att utifrån ett oförändrat jakttryck kommer viltolyckorna att öka med 12% från 2015 fram till 2030, mestadels på grund av en fördubbling av vildsvinsolyckor medan risken för olycka med älg och rådjur minskar något. Vid minskat jakttryck under samma period visar resultaten att det är teoretiskt möjligt att viltolyckorna istället kommer att öka med 50%. Beräknade kostnader för viltolyckor år 2030 (ASEK 6) varierar mellan 1 707 och 7 556 miljoner kronor beroende på antaganden om jakttryck och skadekostnader. Olyckor med rådjur svarar för den största delen av olyckorna under hela perioden, men olyckor med vildsvin ökar mest under samtliga scenarier. Prognos för kostnadsberäkningar av viltolyckor för Västra Götaland och Skåne inkluderas som exempel. Data från 2010–2016 visar att viltolyckorna ökat mer eller mindre konstant sen 2003 och att ökningen i olyckstal över åren sker med snabbare takt än ökningen i trafikarbetet. På mindre vägar tilltar olycksfrekvenser med ökande trafikarbete fram till en genomsnittlig trafikvolym av omkring 5 000 ÅDT. På större vägar avtar däremot olycksfrekvensen med stigande trafik. Olycksfrekvensen är högst på mellanstora vägar men avtar på trafiktunga vägar och på vägar med hög hastighet. Uppdaterade värden för skadeföljd och skadekonsekvens baserades på uttag ur STRADA2 och NVR3 2010–2016 och endast polisrapporterade olyckor (förutom för RPMI4 värden där även sjukhusrapporter ingick). Skadeföljden visar att dödade och skadade personer i älg- och rådjur/hjortolyckor har minskat och justeringar i de nya värdena har gjorts. För skadekonsekvenser föreslås nya värden för älgolyckor medan föregående värden behållits för rådjur/hjort och även föreslås för vildsvin. Nya värden för skadeföljd föreslås för rådjur/hjort och vildsvin. Slutligen diskuteras antagande i effektmodellen och resultat utifrån trafiksäkerhetsutvecklingen, relevanta viltolycksfrågor, samt några utvalda aspekter inför effektmodellens implementering.
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| 10. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Lehmann, I., et al.
(författare)
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Vacuum predictions and measurements for an internal Pellet Target at a storage ring
- 2008
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Ingår i: Vacuum. - : Elsevier BV. - 0042-207X .- 1879-2715. ; 82:6, s. 645-650
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Tidskriftsartikel (refereegranskat)abstract
- Measurements with low Z targets at internal experiments typically imply a gas load which deteriorates the vacuum of a storage ring. Future experiments need reliable estimates for the expected vacuum conditions in order to design 4π detectors closely surrounding the interaction area. We present a method for the calculation of the resulting vacuum of such a complex system using a Pellet Target. In order to test the method, a vacuum system with diagnostic tools has been set-up and a Pellet Target was operated under realistic conditions. The results for the absolute vacuum agree within factors of two with the expected pressures.
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| 13. |
- Lehmann, J.-P., et al.
(författare)
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Long-term functional results after excisional haemorrhoidectomy
- 2020
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Ingår i: Colorectal Disease. - : Wiley. - 1462-8910 .- 1463-1318. ; 22:7, s. 824-830
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Tidskriftsartikel (refereegranskat)abstract
- AimThe aim of this work was to perform a long‐term evaluation of a randomized trial focusing on functional aspects after excisional haemorrhoidectomy with a minimum follow‐up of 9 years.MethodA questionnaire‐based study including patients operated on for haemorrhoids in Sweden between 1999 and 2003. A total of 225 patients were randomized to Milligan’s or Ferguson’s operation. Twenty‐six patients had died and 151 (76%) participated after a median follow‐up of 10.7 years (range 9.2–12.6 years).ResultsSeventy‐seven patients were in the Milligan group and 74 in the Ferguson group. Forty‐eight (32%) reported recurrence. Anal bleeding was reported in 80% at baseline but in 28% at long‐term follow‐up (P < 0.0001). At baseline, 49% had spontaneous anal pain and 25% pain at defaecation. At follow‐up, these figures were 17% and 11%. At follow‐up, 19% described a sense of anal stenosis. At baseline, soiling was reported in 51% but in 20% at long‐term follow‐up (P < 0.001). Nineteen per cent used pads preoperatively and 6% at follow‐up (P < 0.0001). Straining at defaecation was reported by 35% at baseline. At follow‐up, this figure was 25% (P = 0.055).ConclusionSymptoms associated with haemorrhoids were reduced at long‐term follow‐up. The most common problems were perceived recurrence and a sense of anal stenosis.
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| 14. |
- Lind, Monica, et al.
(författare)
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Bone tissue composition, dimensions and strength in female rats given an increased dietary level of vitamin A or exposed to 3,3',4, 4',5-pentachlorobiphenyl (PCB126) alone or in combination with vitamin C.
- 2000
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Ingår i: Toxicology. - 0300-483X .- 1879-3185. ; 151:1-3, s. 11-23
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Tidskriftsartikel (refereegranskat)abstract
- In previous studies we have described structural and functional changes in rat bone tissue caused by 3,3',4,4',5-pentachlorobiphenyl (PCB126). Some of the effects caused by PCB126 resemble those found in vitamin C-deficient rats, as well as those found in rats with a high dietary intake of vitamin A. The present investigation was designed to determine if these PCB126-induced changes could be inhibited by addition of vitamin C to the drinking water and if they could be evoked by vitamin A administration. Five groups of female rats were used in this study, which lasted for 12 weeks. Three of the groups were exposed to PCB126 (total dose 320 microgram/kg, bw), either alone or in combination with vitamin C added to the drinking water (1 and 10 g/l, respectively). One group was given feed with increased level of vitamin A (600000 U/kg pellet) and the fifth group served as controls. Using peripheral quantitative computed tomography (pQCT), it was found that PCB126 increased trabecular density and cortical thickness, but reduced the trabecular area. Furthermore, maximum torque and stiffness of the humerus during torsional testing and serum osteocalcin levels were reduced by PCB126. Of the PCB126 induced effects observed, addition of vitamin C only inhibited the reduction of serum osteocalcin. Like PCB126 vitamin A supplementation increased the inorganic content and the bone density and also reduced the trabecular area and polar moment of inertia but did not increase the cortical thickness or reduce maximum torque, stiffness or serum osteocalcin level. Apparently, the effects induced by PCB126 are not mediated either via decreased vitamin C level or increased vitamin A level.
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| 15. |
- Malmi, Teemu, et al.
(författare)
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Culture and management control interdependence : An analysis of control choices that complement the delegation of authority in Western cultural regions
- 2020
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Ingår i: Accounting, Organizations and Society. - : Elsevier Ltd. - 0361-3682 .- 1873-6289.
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the influence of cultural regions on the interdependence between delegation of authority and other management control (MC) practices. In particular, we assess whether one of the central contentions of agency theory, that incentive contracting and delegation are jointly determined, holds in different cultural regions. Drawing on prior literature, we hypothesise that the MC practices that operate as a complement to delegation vary depending on societal values and preferences, and that MC practices other than incentive contracting will complement delegation in firms in non-Anglo cultural regions. Using data collected from 584 strategic business units across three Western cultural regions (Anglo, Germanic, Nordic), our results show that the interdependence between delegation and incentive contracting is confined to Anglo firms. In the Nordic and Germanic regions, we find that strategic and action planning participation operate as a complement to delegation, while delegation is also complemented by manager selection in Nordic firms. Overall, our study demonstrates that cultural values and preferences significantly influence MC interdependence, and suggests that caution needs to be taken in making cross-cultural generalisations about the complementarity of MC practices.
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| 17. |
- Sheesley, R.J., et al.
(författare)
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Source apportionment of elevated wintertime PAHs by compound-specific radiocarbon analysis
- 2009
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Ingår i: Atmospheric Chemistry And Physics. - 1680-7316 .- 1680-7324. ; 9:10, s. 3347-3356
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Tidskriftsartikel (refereegranskat)abstract
- Natural abundance radiocarbon analysis facilitates distinct source apportionment between contemporary biomass/biofuel (C-14 "alive") versus fossil fuel (C-14 "dead") combustion. Here, the first compound-specific radiocarbon analysis (CSRA) of atmospheric polycyclic aromatic hydrocarbons (PAHs) was demonstrated for a set of samples collected in Lycksele, Sweden a small town with frequent episodes of severe atmospheric pollution in the winter. Renewed interest in using residential wood combustion (RWC) means that this type of seasonal pollution is of increasing concern in many areas. Five individual/paired PAH isolates from three pooled fortnight-long filter collections were analyzed by CSRA: phenanthrene, fluoranthene, pyrene, benzo[b+k] fluoranthene and indeno[cd]pyrene plus benzo[ghi]perylene; phenanthrene was the only compound also analyzed in the gas phase. The measured Delta C-14 for PAHs spanned from -138.3% to 58.0%. A simple isotopic mass balance model was applied to estimate the fraction biomass (fbiomass) contribution, which was constrained to 71-87% for the individual PAHs. Indeno[cd]pyrene plus benzo[ghi]perylene had an fbiomass of 71%, while fluoranthene and phenanthrene (gas phase) had the highest biomass contribution at 87%. The total organic carbon (TOC, defined as carbon remaining after removal of inorganic carbon) fbiomass was estimated to be 77%, which falls within the range for PAHs. This CSRA data of atmospheric PAHs established that RWC is the dominating source of atmospheric PAHs to this region of the boreal zone with some variations among RWC contributions to specific PAHs
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| 19. |
- van der Meer, Dennis, et al.
(författare)
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Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
- 2020
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Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 77:4, s. 420-430
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities.Objective: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance.Design, Setting, and Participants: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019.Main Outcomes and Measures: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2, sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort.Results: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = -0.41; SE, 0.08; P = 4.9 × 10-8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10-7), and a smaller nucleus accumbens (Cohen d = -0.27; SE, 0.07; P = 7.3 × 10-5). There was also a significant negative dose response on cortical thickness (β = -0.24; SE, 0.05; P = 6.8 × 10-7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks.Conclusions and Relevance: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders.
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| 20. |
- Xie, Y., et al.
(författare)
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A critical review on production, modification and utilization of biochar
- 2022
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Ingår i: Journal of Analytical and Applied Pyrolysis. - : Elsevier B.V.. - 0165-2370 .- 1873-250X. ; 161
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Tidskriftsartikel (refereegranskat)abstract
- There has been an increased interest in the production of sustainable biochar in the past years, as biochar shows versatile physicochemical properties and, can have a wide applicability in diverse fields. Comprehensive studies have been made to characterize biochar produced from various biomass materials, using different production technologies and under different process conditions. However, research is still lacking in correlating biochar properties needed for certain applications with (i) feedstock, (ii) biochar production processes and conditions and (iii) biochar upgrading and modification strategies. To produce biochar with desired properties, there is a great need to establish and clarify such correlations, which can guide the selection of feedstock, tuning and optimization of the production process and more efficient utilization of biochar. On the other hand, further elucidation of these correlations is also important for biochar-stakeholder and end-users for predicting physiochemical properties of biochar from certain feedstock and production conditions, assessing potential effects of biochar utilization and clearly address needs towards biochar critical properties. This review summarizes a wide range of literature on the impact of feedstocks and production processes and reactions conditions on the biochar properties and the most important biochar properties required for the different potential applications. Based on collected data, recommendations are provided for mapping out biochar production for different biochar applications. Knowledge gaps and perspectives for future research have also been identified regarding the characterization and production of biochar.
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| 21. |
- Ölvander, J., et al.
(författare)
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Preface
- 2018
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Ingår i: Proceedings of NordDesign. - Linköping : Design Research Society. - 9789176851852
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Konferensbidrag (populärvet., debatt m.m.)
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| 22. |
- Ölvander, J., et al.
(författare)
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Preface
- 2018
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Ingår i: Proceedings of NordDesign. - : The Design Society.
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Konferensbidrag (refereegranskat)
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