| 1. |
- Dahlqvist, Per, et al.
(författare)
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Effects of postischemic environment on transcription factor and serotonin receptor expression after permanent focal cortical ischemia in rats
- 2003
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Ingår i: Neuroscience. - 1873-7544 .- 0306-4522. ; 119:3, s. 643-652
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Tidskriftsartikel (refereegranskat)abstract
- Housing rats in an enriched environment improves functional outcome after ischemic stroke, this may reflect neuronal plasticity in brain regions outside the lesion. Which components of the enriched environment that are of greatest importance for recovery after brain ischemia is uncertain. We have previously found that enriched environment and social interaction alone both improve functional recovery after focal cerebral ischemia, compared with isolated housing with voluntary wheel-running. In this study, the aim was to separate components of the enriched environment and investigate the effects on some potential mediators of improved functional recovery; such as the inducible transcription factors nerve growth factor-induced gene A (NGFI-A) and NGFI-B, and the glucocorticoid and serotonin systems. After permanent middle cerebral artery occlusion, rats were divided into four groups: individually housed with no equipment (deprived group), individually housed with free access to a running wheel (running group), housed together in a large cage with no equipment (social group) or in a large cage furnished with exchangeable bars, chains and other objects (enriched group). mRNA expression of inducible transcription factors, serotonin and glucocorticoid receptors was determined with in situ hybridisation 1 month after cerebral ischemia. Rats housed in enriched or social environments showed significantly higher mRNA expression of NGFI-A and NGFI-B in cortical regions outside the lesion and in the CA1 (cornu ammonis region of the hippocampus), compared with isolated rats with or without a running wheel. NGFI-A and NGFI-B mRNA expression in cortex and in CA1 was significantly correlated to functional outcome. 5-Hydroxytryptamine receptor 1A (5-HT1A) mRNA expression and binding, as well as 5-HT2A receptor mRNA expression were decreased in the hippocampus (CA4 region) of the running wheel rats. Mineralocorticoid receptor gene expression was increased in the dentate gyrus amongst wheel-running rats. No group differences were found in plasma corticosterone levels or mRNA levels of glucocorticoid receptor, corticotropin-releasing hormone, 5-HT2C or c-fos. In conclusion, we have found that social interaction is a major component of the enriched environment regarding the effects on NGFI-A and NGFI-B expression. These transcription factors may be important mediators of improved functional recovery after brain infarctions, induced by environmental enrichment. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
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| 2. |
- Engstrand, Per O., 1955-, et al.
(författare)
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Mekmassainitiativet för energieffektivitet, e2mp-i
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet har drivits som ett program för finansiering av forskning som ska utveckla ochdemonstrera tekniker som reducerar elenergiförbrukningen med 50% vid tillverkning avTMP och CTMP med bibehållna slutproduktegenskaper hos tryckpapper och kartong.Programmet är en del av skogsindustrins initiativ att under en tioårsperiod tillsammansmed svenska och norska finansiärer investera minst 200 Mkr för att nå detta radikalaeffektiviseringsmål. Ett uttalat mål för industriinitiativet är också att befästaforskningsnoderna vid FSCN i Sundsvall och PFI i Trondheim.Parallellt med Energimyndighetens finansiering, 30 Mkr, har Norges Forskningsråd satsat25 MNOK (2010‐14) i industriinitiativet, KK‐stiftelsen 36 MSEK (2011‐17) ochMittuniversitetet har finansierat12 MSEK. Industrins totala satsning kommer att överstiga100 MSEK redan vid utgången av 2017.Resultat från benchmarkingstudien BAT2012 av industrins modernaste TMP‐ och CTMPlinjersamt från demonstrationsskaleprojekt visas i rapporten. Projekten baseras delvis pågrundläggande forskningsprojekt genomförda inom FSCN´s KK‐stiftelse‐finansieradeforskningsprofil och projektet ”Filling the Gap” 31676‐, ISSN 1650‐5387 2014:57. Resultaten visar följande reduktionsnivåer; 28% TMP för news (Braviken), 14% TMP för SC(Kvarnsveden) och 21% CTMP för kartong (Skoghall).Utöver demoprojekten finns ytterligare tydliga potentialer beskrivna i övriga delprojekt:Processintensifiering och processmodifiering > 15%Processtabilitet via avancerad processanalys och reglering > 15%Kombinera effektivaste processavsnitt från benchmarking ca 25%Detta gör det troligt att det kommer att gå att i fullskaliga demonstrationsförsök validera50% elenergireduktion inom de tre produktområdena, förutsatt att fortsattforskningsfinansiering finns tillgänglig. Tre av de idéer till avknoppningsprojekt somframkommit under projektets gång har redan erhållit beslut om finansiering frånEnergimyndigheten 2015. Ytterligare projektförslag baserade på den här redovisadeforskningen kommer att ingå i ansökningar under 2016. Utöver energireduktion i själva TMP‐ och CTMP‐processerna har forskare vid FSCN lagt forskningsgrunden för hur manska kunna tillverka mycket starka förpackningsmaterial från dessa massatyper på ettenergieffektivt sätt. Även inom detta område kommer en ansökning omuppskalningsprojekt att skickas in.
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| 3. |
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| 4. |
- Rasmussen, Eva Rye, et al.
(författare)
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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
- 2020
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Ingår i: The Pharmacogenomics Journal. - : Springer Science and Business Media LLC. - 1470-269X .- 1473-1150. ; 20:6, s. 770-783
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Tidskriftsartikel (refereegranskat)abstract
- Angioedema in the mouth or upper airways is a feared adverse reaction to angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) treatment, which is used for hypertension, heart failure and diabetes complications. This candidate gene and genome-wide association study aimed to identify genetic variants predisposing to angioedema induced by these drugs. The discovery cohort consisted of 173 cases and 4890 controls recruited in Sweden. In the candidate gene analysis, ETV6, BDKRB2, MME, and PRKCQ were nominally associated with angioedema (p < 0.05), but did not pass Bonferroni correction for multiple testing (p < 2.89 × 10-5). In the genome-wide analysis, intronic variants in the calcium-activated potassium channel subunit alpha-1 (KCNMA1) gene on chromosome 10 were significantly associated with angioedema (p < 5 × 10-8). Whilst the top KCNMA1 hit was not significant in the replication cohort (413 cases and 599 ACEi-exposed controls from the US and Northern Europe), a meta-analysis of the replication and discovery cohorts (in total 586 cases and 1944 ACEi-exposed controls) revealed that each variant allele increased the odds of experiencing angioedema 1.62 times (95% confidence interval 1.05-2.50, p = 0.030). Associated KCNMA1 variants are not known to be functional, but are in linkage disequilibrium with variants in transcription factor binding sites active in relevant tissues. In summary, our data suggest that common variation in KCNMA1 is associated with risk of angioedema induced by ACEi or ARB treatment. Future whole exome or genome sequencing studies will show whether rare variants in KCNMA1 or other genes contribute to the risk of ACEi- and ARB-induced angioedema.
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| 5. |
- Turcot, Valerie, et al.
(författare)
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- 2018
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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| 6. |
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| 7. |
- Andersson, Mattias, 1985, et al.
(författare)
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Dielectric strength of γ-radiation cross-linked, high vinyl-content polyethylene
- 2015
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Ingår i: European Polymer Journal. - : Elsevier BV. - 0014-3057. ; 64, s. 101-107
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Tidskriftsartikel (refereegranskat)abstract
- We explore γ-radiation cross-linking of high vinyl-content low-density polyethylene (LDPE) and its potential use as a high-voltage insulation material. Of the three investigated resins containing 1, 0.5 and 0.17 vinyl groups per 1000 carbons, respectively, only the highest vinyl-content material featured a sufficiently high gel content of more than 70% and hot-set elongation below 175%, when cross-linked with a γ-radiation dose of at least 68 kGy. Differential scanning calorimetry (DSC) and small-angle X-ray scattering (SAXS) reveal that neither the crystallinity nor the lamellar thickness of the highest vinyl-content LDPE are negatively affected by γ-radiation cross-linking. As a result, we find that the dielectric strength, as characterized by electrical tree initiation experiments, can be maintained upon γ-radiation cross-linking.
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| 8. |
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| 9. |
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| 10. |
- Aranda-Guillén, Maribel, et al.
(författare)
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A polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies.
- 2023
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Ingår i: Journal of internal medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 294:1, s. 96-109
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Tidskriftsartikel (refereegranskat)abstract
- Autoimmune Addison's disease (AAD) is the most common cause of primary adrenal insufficiency (PAI). Despite its exceptionally high heritability, tools to estimate disease susceptibility in individual patients are lacking. We hypothesized that polygenic risk score (PRS) for AAD could help investigate PAI pathogenesis in pediatric patients.We here constructed and evaluated a PRS for AAD in 1223 seropositive cases and 4097 controls. To test its clinical utility, we reevaluated 18 pediatric patients, whose whole genome we also sequenced. We next explored the individual PRS in more than 120 seronegative patients with idiopathic PAI.The genetic susceptibility to AAD-quantified using PRS-was on average 1.5 standard deviations (SD) higher in patients compared with healthy controls (p<2e-16), and 1.2 SD higher in the young patients compared with the old (p=3e-4). Using the novel PRS, we searched for pediatric patients with strikingly low AAD susceptibility and identified cases of monogenic PAI, previously misdiagnosed as AAD. By stratifying seronegative adult patients by autoimmune comorbidities and disease duration we could delineate subgroups of PRS suggesting various disease etiologies.The PRS performed well for case-control differentiation and susceptibility estimation in individual patients. Remarkably, a PRS for AAD holds promise as a means to detect disease etiologies other than autoimmunity.
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| 11. |
- Artaza, Haydee, et al.
(författare)
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Rare copy number variation in autoimmune Addison's disease
- 2024
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Autoimmune Addison's disease (AAD) is a rare but life-threatening endocrine disorder caused by an autoimmune destruction of the adrenal cortex. A previous genome-wide association study (GWAS) has shown that common variants near immune-related genes, which mostly encode proteins participating in the immune response, affect the risk of developing this condition. However, little is known about the contribution of copy number variations (CNVs) to AAD susceptibility. We used the genome-wide genotyping data from Norwegian and Swedish individuals (1,182 cases and 3,810 controls) to investigate the putative role of CNVs in the AAD aetiology. Although the frequency of rare CNVs was similar between cases and controls, we observed that larger deletions (>1,000 kb) were more common among patients (OR = 4.23, 95% CI 1.85-9.66, p = 0.0002). Despite this, none of the large case-deletions were conclusively pathogenic, and the clinical presentation and an AAD-polygenic risk score were similar between cases with and without the large CNVs. Among deletions exclusive to individuals with AAD, we highlight two ultra-rare deletions in the genes LRBA and BCL2L11, which we speculate might have contributed to the polygenic risk in these carriers. In conclusion, rare CNVs do not appear to be a major cause of AAD but further studies are needed to ascertain the potential contribution of rare deletions to the polygenic load of AAD susceptibility.
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| 12. |
- Barow, Thomas, 1969, et al.
(författare)
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Elevassistenter i särskolan: mellan elever och speciallärare : Student assistants in special school: between student and special teacher
- 2021
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Ingår i: Forskning pågår.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Den presenterade studien tar upp elevassistenters roll och uppgift i särskolan. Det empiriska materialet består av en enkätstudie med 60 elevassistenter och halvstrukturerade intervjuer mer fyra speciallärare och fem elevassistenter. Resultaten diskuteras baserande på ”street-level bureaucracy”-ansatsen och fokuserar på elevassisternas intermediära roll mellan speciallärare och elev i grundsärskolan. Elevassistenterna upplever avsaknad av stöd i sin professionella utveckling. Baserande på bristande resurser och omfattande uppgifter har de begränsade möjligheter i att kooperera med specialläraren gällande undervisningens planering, genomförande och evaluering. Komplexiteten att inneha både en undervisande och en omsorgsorienterad roll i klassrum diskuteras, särskilt med hänsyn till elevers välmående och relationer till andra elever.
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| 13. |
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| 14. |
- Bergh, Ingrid H. E., et al.
(författare)
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Assessment and documentation of women's labour pain : A cross-sectional study in Swedish delivery wards
- 2015
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Ingår i: Women and Birth. - : Elsevier. - 1871-5192 .- 1878-1799. ; 28:2, s. E14-E18
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Tidskriftsartikel (refereegranskat)abstract
- Background: A woman's pain during labour plays a dominant role in childbirth. The midwife's role is to assess the degree of pain experienced during labour. When professionals respond to labour pain with acknowledgement and understanding, the woman's sense of control and empowerment is increased, which could contribute to a positive experience of childbirth. The aim of this study is to describe how labour pain in Swedish delivery wards is assessed and documented. Methods: This quantitative descriptive study was designed as a national survey performed through telephone interviews with the representatives of 34 delivery wards in Sweden. Results and conclusion: The majority of the participating delivery wards assessed and documented women's labour pain, but in an unstructured manner. The wards differed in how the assessments and documentation were performed. In addition, almost all the delivery wards that participated in the survey lacked guidelines for the assessment and documentation of the degree of pain during labour. The findings also showed that the issue of labour pain was sometimes discussed in the delivery wards, but not in a structured or consistent way. (C) 2015 Australian College of Midwives. Published by Elsevier Australia (a division of Reed International Books Australia Pty Ltd). All rights reserved.
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| 15. |
- Beyer, Sarah, 1982-, et al.
(författare)
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Fluorescent Molecularly Imprinted Polymer Layers against Sialic Acid on Silica-Coated Polystyrene Cores — Assessment of the Binding Behavior to Cancer Cells
- 2022
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:8
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Tidskriftsartikel (refereegranskat)abstract
- Sialic acid (SA) is a monosaccharide usually linked to the terminus of glycan chains on the cell surface. It plays a crucial role in many biological processes, and hypersialylation is a common feature in cancer. Lectins are widely used to analyze the cell surface expression of SA. However, these protein molecules are usually expensive and easily denatured, which calls for the development of alternative glycan-specific receptors and cell imaging technologies. In this study, SA-imprinted fluorescent core-shell molecularly imprinted polymer particles (SA-MIPs) were employed to recognize SA on the cell surface of cancer cell lines. The SA-MIPs improved suspensibility and scattering properties compared with previously used core-shell SA-MIPs. Although SA-imprinting was performed using SA without preference for the α2,3-and α2,6-SA forms, we screened the cancer cell lines analyzed using the lectins Maackia Amurensis Lectin I (MAL I, α2,3-SA) and Sambucus Nigra Lectin (SNA, α2,6-SA). Our results show that the selected cancer cell lines in this study presented a varied binding behavior with the SA-MIPs. The binding pattern of the lectins was also demonstrated. Moreover, two different pentavalent SA conjugates were used to inhibit the binding of the SA-MIPs to breast, skin, and lung cancer cell lines, demonstrating the specificity of the SA-MIPs in both flow cytometry and confocal fluorescence microscopy. We concluded that the synthesized SA-MIPs might be a powerful future tool in the diagnostic analysis of various cancer cells.
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| 16. |
- Bjursell, Cecilia, 1970-, et al.
(författare)
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Higher education as learning organizations – An empirical study of education managers perception of their work situation
- 2022
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Ingår i: NFF 2022 Conference Papers.
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Konferensbidrag (refereegranskat)abstract
- The paper presents a study of Swedish academic leaders’ perception of their work situation. The aim was to explore the conditions which can enable creativity and learning in higher education institutions. The KEYS survey was sent to a sample of 64 university managers from social sciences, humanities and technical departments at Swedish universities. The response rate was 39 % (n25). The result indicates that education managers perceive a lack of feedback from upper management, but at the same time, they claim to have a high level of trust from upper management.
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| 17. |
- Bornmalm, Lennart, 1956, et al.
(författare)
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Bevara det flytande kulturarvet Kingston – 85 fots räktrålare
- 2003
-
Ingår i: Bohuslän (Fisk); Overland, V., Carlsson, L. och Möller, P (Red). - Uddevalla : Bohusläns museum. - 0348-937X. - 9176861937 ; , s. 161-164
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 18. |
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| 19. |
- Broström, Stig, et al.
(författare)
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Preschool teachers' view on learning in preschool in Sweden and Denmark
- 2014
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Ingår i: European Early Childhood Education Research Journal. - 1350-293X .- 1752-1807. ; 22:5, s. 590-603
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine how preschool teachers in Sweden and Denmark perceive children's learning in preschool. The study aimed to answer the following questions: What is 'learning'? How do children learn? What are the best conditions for children's learning? What is the role of participation in children's learning? The results show that from the teacher's perspectives, children's learning is connected to children's social interaction and development in which the children's initiatives are crucial. Learning, to a great extent, results from children's active involvement. There are many similarities between how Danish and Swedish preschool teachers think of learning and participation. This supports earlier assumption about the coherence of Nordic preschool beliefs which unites education and care.
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| 20. |
- Broström, Stig, et al.
(författare)
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Preschool teachers' views on children's learning : an international perspective
- 2015
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Ingår i: Early Child Development and Care. - : Informa UK Limited. - 0300-4430 .- 1476-8275. ; 185:5, s. 824-847
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Tidskriftsartikel (refereegranskat)abstract
- This comparative study investigated the perspectives of preschool teachers in Australia, Denmark, Estonia, German, Greece and Sweden about learning and participation in preschool. A structured survey questionnaire investigated four main questions: What situations can be characterised as learning? What activities are important for learning? What are the best conditions for children's learning? How do preschool teachers understand participation in relation to children's learning in preschool? Results suggest that play, interactions with other children and adults, the provision of different activities and teacher support are important for children's learning. While similarities were noted, results indicate some disparity between countries and a further in-depth interview-style study is recommended to provide a deeper understanding of teachers' perspectives and practices around children's learning.
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| 21. |
- Börve, Alexander, et al.
(författare)
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Smartphone Teledermoscopy Referrals: A Novel Process for Improved Triage of Skin Cancer Patients.
- 2015
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Ingår i: Acta dermato-venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 95:2, s. 186-190
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Tidskriftsartikel (refereegranskat)abstract
- In this open, controlled, multicentre and prospective observational study, smartphone teledermoscopy referrals were sent from 20 primary healthcare centres to 2 dermatology departments for triage of skin lesions of concern using a smartphone application and a compatible digital dermoscope. The outcome for 816 patients referred via smartphone teledermoscopy was compared with 746 patients referred via the traditional paper-based system. When surgical treatment was required, the waiting time was significantly shorter using teledermoscopy for patients with melanoma, melanoma in situ, squamous cell carcinoma, squamous cell carcinoma in situ and basal cell carcinoma. Triage decisions were also more reliable with teledermoscopy and over 40% of the teledermoscopy patients could potentially have avoided face-to-face visits. Only 4 teledermoscopy referrals (0.4%) had to be excluded due to poor image quality. Smartphone teledermoscopy referrals allow for faster and more efficient management of patients with skin cancer as compared to traditional paper referrals.
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| 22. |
- Carling, Anna, 1985-
(författare)
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Impaired balance and fall risk in people with multiple sclerosis
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The symptoms from the neurological disease multiple sclerosis vary from person to person and over time. Impaired balance is common in people with multiple sclerosis and can lead to falls. Fall frequency is high in people with multiple sclerosis, above 50%. Multiple sclerosis affects not only the person having the disease but also their next of kin. To be able to reduce fall risk it is important to know when, why and where people with multiple sclerosis fall, and how to improve balance and reduce falls with exercise. It is also important to know how the falls affect the residing next of kin to people with multiple sclerosis.The overall aim of this thesis was to gain enhanced knowledge by investigating when and why people with MS fall and how these falls possibly affect their next of kin, and also to evaluate the effects and perceptions of participating in a specific balance exercise.Data were gathered using four different data collections, and this thesis contains both qualitative and quantitative data.The major finding in this thesis is that people with multiple sclerosis fall in the course of everyday life activities, most often in their own homes due to various intrinsic and extrinsic factors. Balance can be improved and falls reduced and everyday life may be made easier and facilitated after participating in the CoDuSe balance exercise. This is important also for the next of kin, since they are adapting, adjusting and renouncing their activities due to the falls of the PwMS, in order to make it work for the whole family.
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| 23. |
- Corvellec, Hervé, 1961, et al.
(författare)
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Avfallsförebyggande handlar om effektiv produktion och genomtänkt konsumtion – inte om avfall. Sju lärdomar från forskningsprojektet från avfallshantering till avfallsförebyggande
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport sammanfattar de viktigaste lärdomarna från forskningsprojektet ”Från avfallshantering till avfallsförebyggande”. I forskningsprojektet har forskare från Lunds universitet och Göteborgs universitet, men också Umeå Universitet och Kungliga Tekniska Högskolan, studerat avfallsförebyggande. Syftet med projektet har varit att identifiera och förklara svårigheterna med att förverkliga de avfallsförebyggandepolitiska målen. Forskarna har närmat sig projektets syfte genom innehållsanalys av avfallsplaner, kvantitativa och kvalitativa studier av avfallsförebyggande- initiativ, teoretisk kritik av stadsplanering, och kartläggning av hinder för avfallsförebyggande. Projektet har bedrivits i tät samverkan med kommuner, kommunala avfallsbolag, myndigheter, sociala rörelser och företag. Det har finansierats av forskningsrådet Formas (Dnr 259-2013-210). För den som vill veta mer finns källor refererade löpande i texten och redovisat i referenslistan i slutet av rapporten. Det går även bra att kontakta respektive forskare. Under Interna referenser redovisas de vetenskapliga artiklar, konferensbidrag, seminarier, uppsatser, reportage, debattartiklar, och nya forskningsprojekt som forskningsprojektet har lett till. På projektets webbplats www.ism.lu.se/mtp redogörs i detalj för projektet, till exempel de workshopar som har organiserats inom projektets ram.
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| 24. |
- Corvellec, Hervé, et al.
(författare)
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Waste prevention is about effective production and thoughtful consumption – not about waste : Seven lessons from the research project from waste management to waste prevention
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report summarises the most important lessons learned from the research project From waste management to waste prevention. In the research project, researchers from Lund University and the University of Gothenburg, but also Umeå University and the Royal Institute of Technology, have studied waste prevention.The aim of the project has been to identify and clarify the difficulties in realising the goals of waste prevention policy. Researchers have approached the project’s purpose through content analysis of waste plans, quantitative and qualitative studies of waste prevention initiatives, criticism of urban planning theory, andthe mapping of obstacles to waste prevention.The project has been conducted in close cooperation with municipalities, municipal waste companies, authorities, social movements and companies. It has been financed by the Research Council Formas (Ref. no. 259-2013-210).
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| 25. |
- Dahl, Marianne, 1954-
(författare)
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Fritidspedagogers handlingsrepertoar : Pedagogiskt arbete med barns olika relationer
- 2014
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis aims to make a contribution to our current understanding regarding leisure-time pedagogues’ work with children’s relationships. Here focus is placed on the collective action repertoire as expressed by two different groups of leisure-time pedagogues. The research questions addressed are: How do leisure-time pedagogues work with children’s relationships and how do they view such relationships? What communities do they identify? What qualities in children’s relationships do they regard as desirable? The theoretical framework of this study is based on Wenger’s (1998) social theory regarding learning in communities of practice, as well as Gergen’s theory of relationships as an inevitable part of human existence. Consequently, within this thesis relationships are viewed as mainly negotiated and are therefore dynamic in character. The methodological approach is ethnographic, focusing on leisure-time pedagogues’ work with and talk about children’s relationships. The study is based on data derived from eight leisure-time pedagogues divided into two different work teams of four pedagogues, covering two different leisure-time centres and involving 60 children of 6-11 years of age. Final analysis is based on concepts derived from both Wenger’s and Gergen’s theories, for example; action repertoire, relational qualities, communities of practice and shared interests. Results suggest that the communities of practice and the alliances that pedagogues identify are often gender-related and built on common interests. The pedagogues’ action repertoire illustrates a desire to facilitate encounters between children and promote harmonious relationships. Leisure-time pedagogues support relationships characterized by consensus, respect, confidence and adaptation to rules, whereas those marked by conflict, disharmony, breaking rules or aggressions are counteracted. Various notions emerge in pedagogues’ action repertoire based on normative thinking, where different relational competences are ascribed to children. Some children are described as relationally competent while other children, who do not adapt themselves in a desirable manner, are described as having difficulties adjusting their relational competence. The results also reveal a lack of guidelines for handling the variety of differences in children’s relationships and display the lack of a common professional language for verbalizing children’s relational work.
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| 26. |
- de Ron, Anette, 1966-
(författare)
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Problemlösning i matematikdidaktik och lärarutbildning : Ett mångdisciplinärt utforskande och affirmativ kritik
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis in mathematics education is to produce knowledge about problem-solving as a broad and complex phenomenon in mathematics teacher education, historically and in the present. With a multidisciplinary approach and affirmative critique, possible new understandings of the phenomenon are investigated, extended and transformed in three sub-studies and two chapters in the wrapping. The thesis builds on previous research on teacher education but seeks to contribute to a multidimensional understanding of the phenomenon of problem-solving. The first sub-study provides a configurative research review that offers a picture of the different relationships in which problem-solving is involved, and how different aspects of problem-solving are highlighted and become complementary. The second sub-study is a discourse analysis of historical texts on problem-solving where the data consists of texts written for and by teachers from the 1840s and onwards. The sub-study shows how discursive truths about problem-solving are formed and consolidated over time. The third sub-study brings attention to the materiality of problem-solving teaching, and highlights how mathematics teaching in secondary school, in the form of classroom observations, can be understood in a new materialist perspective. In addition, the thesis includes further analysis of problem-solving – presented in two chapters in the wrapping – and as a consequence the thesis may is designed as a hybrid between a compilation thesis and a monograph. In one of the chapters, previous research is traced diffractively with regard to the arguments put forward as to why problem-solving is important. In the other chapter, the results of the three sub-studies are read diffractively, through and with feminist new materialism. The thesis spans over several theoretical-methodological fields and takes the reader on a walk through the problem-solving landscape. The overall results show that problem-solving is a composed phenomenon that appears in different ways in different theoretical perspectives and methodological starting points, as well as in different times and spaces. To summarize, the thesis shows that 1) there is a need for teacher education to encourage pre-service teachers to acknowledge the multiplicity regarding both knowledge of problem-solving and the solving of problems, 2) teaching in teacher education can make visible, but also question, dualities such as thinking–acting, body–soul, rationality–emotions, woman–male in order to find other ways of understanding problem-solving, 3) when aspects of gender, inequality and other sociopolitical issues are addressed in mathematics education content in teacher education, problem-solving can be linked even more to a societal context, 4) the consideration and handling of emotions in relation to mathematics is significant as a knowledge in itself and contributes to a more composed understanding of problem-solving, and 5) new dimensions of problem-solving can emerge when the planning of mathematics teaching is based on a relational understanding of learning and supported by new materialist theory. The thesis contributes with new ways of thinking about problem-solving as a composed phenomenon, what it can entail and become, and provides suggestions for an expanded and 'respons-able' understanding of problem-solving that can contribute to further develop mathematics education in teacher education.
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| 27. |
- de Villiers, Sabina H. L., et al.
(författare)
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Nicotine hapten structure, antibody selectivity and effect relationships : Results from a nicotine vaccine screening procedure
- 2010
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Ingår i: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 28:10, s. 2161-2168
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to synthesise and screen a set of novel nicotine hapten immunogens used for the treatment of nicotine dependence. In the screening process we studied the amount of antibodies generated and their selectivity, using ELISA techniques, and their effects on nicotine-induced dopamine release in the NAC(shell) of the rat, assessed by in vivo voltammetry. We conclude that even small changes such as the linker attachment on the nicotine molecule as well as the structure of the linker may greatly influence the selectivity of the antibodies and the central neurobiological effects of nicotine that are considered critical for its dependence producing properties. (C) 2010 Elsevier Ltd. All rights reserved.
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| 28. |
- Ding, Ming, et al.
(författare)
-
Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study
- 2017
-
Ingår i: The BMJ. - : BMJ Publishing Group Ltd. - 1756-1833 .- 0959-8138. ; 356
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. DESIGN Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. SETTING CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. PARTICIPANTS Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis. MAIN OUTCOME MEASURES The instrumental variable estimation was conducted using the ratio of coefficients approach. Using metaanalysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized. RESULTS Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P<0.001) and was not associated with systolic blood pressure (0.31, 95% confidence interval -0.05 to 0.68 mm Hg; P=0.09) or risk of hypertension (odds ratio 1.01, 95% confidence interval 0.97 to 1.05; P=0.27). Using LCT-13910 rs4988235 as the instrumental variable, genetically determined dairy consumption was not associated with systolic blood pressure (beta=1.35, 95% confidence interval -0.28 to 2.97 mm Hg for each serving/day) or risk of hypertension (odds ratio 1.04, 0.88 to 1.24). Moreover, meta-analysis of the published clinical trials showed that higher dairy intake has no significant effect on change in systolic blood pressure for interventions over one month to 12 months (intervention compared with control groups: beta=-0.21, 95% confidence interval -0.98 to 0.57 mm Hg). In observational analysis, each serving/day increase in dairy consumption was associated with -0.11 (95% confidence interval -0.20 to -0.02 mm Hg; P=0.02) lower systolic blood pressure but not risk of hypertension (odds ratio 0.98, 0.97 to 1.00; P=0.11). CONCLUSION The weak inverse association between dairy intake and systolic blood pressure in observational studies was not supported by a comprehensive instrumental variable analysis and systematic review of existing clinical trials.
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| 29. |
- Doedens, Espen, 1988, et al.
(författare)
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Effects of Inclusions of Oxidized Particles in XLPE on Treeing Phenomena
- 2012
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Ingår i: Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP. - 0084-9162. ; , s. 597-600
-
Konferensbidrag (refereegranskat)abstract
- One issue with the use of crosslinked polyethylene (XLPE) insulation in high voltage power cables is the presence of oxidized particles. Oxidation may occur during production of polyethylene, during the extrusion and curing process used to produce XLPE cables, or in subsequent processes/operation of the cables. Oxidized particles are here referred to as organic contaminants. In the present study artificial organic contaminants were introduced in XLPE samples made for electrical treeing measurements. Instead of using the common needle-needle or needle-plane configuration, a wire-plane configuration was used. Organic contaminants have an increasing conductivity and permittivity as function of increasing degree of oxidation. These properties most probably give rise to local electric field enhancements in the material. The morphology of organic contaminants also differs from virgin XLPE, which probably cause bad adhesion between the XLPE matrix and the contaminants. A combination of these factors was found to affect the electrical performance of the insulation. Several different parameters, such as dry and wet ageing, as well as AC voltage and DC voltage stress, were included in the study.
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| 30. |
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| 31. |
- Duarte-Salles, Talita, et al.
(författare)
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Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
- 2015
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Ingår i: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 137:11, s. 2715-2728
-
Tidskriftsartikel (refereegranskat)abstract
- The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
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| 32. |
- Ehrström, Monica, 1970-
(författare)
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Uppmärksamhet för bedömning : att följa varje barns lärprocesser för en likvärdig utbildning i förskolan
- 2023
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of this study was to contribute with knowledge about the tension between preschool teachers' mission to teach and support children's learning on the one hand and the mission to assess children's learning processes on the other hand, in relation to equality in education. In Swedish preschools, children with different experiences meet, all of whom should have the opportunity to develop and learn based on their varied circumstances and needs. According to the Education Act (SFS, 2010:800), preschool education must be equal, and all children must have the opportunity to learn and develop as far as possible based on their potential. However, previous research (Alasuutari, Vallberg Roth & Markström, 2014) indicates that assessment involves risks for children’s identity creation. This study examines how seven preschool teachers tackle the challenge of assessing and paying attention to individual children in their ongoing learning processes. A sociocultural perspective (Vygotskij, 1978) has been used to study preschool teachers' reasoning about assessment in relation to each child's possibilities for being supported in their proximal development zone. The sociocultural perspective stresses the importance of cultural tools for communication. Stimulated-recall interviews were conducted with seven preschool teachers in Sweden. Content analysis was used to reveal the views that emerged in preschool teachers’ descriptions.In the preschool teachers' reasoning, different strategies for assessment and methods for making the child's learning processes visible as well as approaches for following the progression in children's learning processes have emerged, which can create both opportunities and limitations for children to learn based on their potential. Findings indicate three areas significant for assessment in relation to an equivalent education in this study. Firstly, there is clarity regarding the approach to assessment, what is to be given attention and assessed and how the assessment should be carried out. Secondly, the preschool teachers in the study have knowledge about various methods to make children's learning processes visible and thus possible to follow over time. Thirdly, the preschool teachers in the study know how to draw attention to and make visible the child's learning from a holistic perspective. The Licentiate thesis highlights different strategies for assessment, methods for making the child's learning processes visible and approaches for following the progression in children's learning processes that emerged during the preschool teachers' reasoning. The study has shown that attentiveness (Elbaz, 1992) can be used as a concept to bridge the tension surrounding assessment.
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| 33. |
- Einarsdottir, Johanna, et al.
(författare)
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Democracy, caring and competence : values perspectives in ECEC curricula in the Nordic countries
- 2015
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Ingår i: International Journal of Early Years Education. - : Routledge. - 0966-9760 .- 1469-8463. ; 23:1, s. 97-114
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of the study is to explore how Nordic Early Childhood Education and Carepolicies frame values education in preschools with a special focus on the values ofdemocracy, caring and competence. The study is part of a larger Nordic project, Valueseducation in Nordic preschools: Basis of education for tomorrow, the aim of which isto explore values education from various perspectives, policy levels, institutional levelsand personal levels. The study applies Habermas’s theoretical ideas of communicativeactions, lifeworld, and the system. Here the focus is on the system level, namely, valuesin national curriculum guidelines that serve as the basis of pedagogical practices inpreschools in the Nordic countries. Thematic research analysis described by Braun andClarke inspired the qualitative analysis of the documents. In addition, a quantitativelanguage-based approach was applied to the study. Keywords related with democratic,caring and competence values were selected. The findings reveal different dimensionsand meanings of the three value fields, such as democracy as being and/or becoming;care as fulfilment of basic needs and an ethical relationship; and competence values aslearning for sociality and academic skills.
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| 34. |
- Einarsdottir, Sigrun, et al.
(författare)
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Vaccination against tick-borne encephalitis (TBE) after autologous and allogeneic stem cell transplantation
- 2021
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Ingår i: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 39:7, s. 1035-1038
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Our aim was to assess response and side effects of 4 doses of TBE vaccine to patients (pts) after allo- and autologous stem cell transplantation (SCT). PATIENTS: Included were 104 pts with leukaemia, myeloma and lymphoma, median age 61 yrs. METHODS: Vaccine (FSME-Immun (R)) was given at 9, 10, 12, and 21 months post-transplant. Serum samples were obtained before and after vaccinations. Healthy controls (n = 27) received 3 vaccinations. Assessments of TBE specific IgG antibodies were performed by Enzygnost anti-TBE ELISA test (Siemens, Sweden). Results: Antibody levels (>12 U/mL; "seropositivity") were seen in 77% and 80% of pts after allo- and autoSCT; IgG levels; 89 vs 94 U/mL. Ongoing chronic GvHD and immunosuppression (n = 29) was associated with sero-negativity in the last sample (p = 0.007). All controls (n = 27) developed protective antibody levels. Conclusions: TBE vaccination was safe, and 4 doses starting 9 months post-SCT, induced seropositivity in a vast majority of pts. (C) 2021 Elsevier Ltd. All rights reserved.
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| 35. |
- Ekman, Carl Johan, et al.
(författare)
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A History of Psychosis in Bipolar Disorder is Associated With Gray Matter Volume Reduction.
- 2017
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Ingår i: Schizophrenia bulletin. - : Oxford University Press (OUP). - 1745-1701 .- 0586-7614. ; 43:1, s. 99-107
-
Tidskriftsartikel (refereegranskat)abstract
- Psychotic symptoms are prevalent in schizophrenia, bipolar disorder, and other psychiatric and neurological disorders, yet the neurobiological underpinnings of psychosis remain obscure. In the last decade, a large number of magnetic resonance imaging studies have shown differences in local gray matter volume between patients with different psychiatric syndromes and healthy controls. Few studies have focused on the symptoms, which these syndromes are constituted of. Here, we test the association between psychosis and gray matter volume by using a sample of 167 subjects with bipolar disorder, with and without a history of psychosis, and 102 healthy controls. Magnetic resonance images were analyzed on group level using a voxel-wise mass univariate analysis (Voxel-Based Morphometry). We found that patients with a history of psychosis had smaller gray matter volume in left fusiform gyrus, the right rostral dorsolateral prefrontal cortex, and the left inferior frontal gyrus compared with patients without psychosis and with healthy controls. There was no volume difference in these areas between the no-psychosis group and healthy controls. These areas have previously been structurally and functionally coupled to delusions and hallucinations. Our finding adds further evidence to the probability of these regions as key areas in the development of psychotic symptoms.
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| 36. |
- El-Schich, Zahra, et al.
(författare)
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Sialic acid as a biomarker studied in breast cancer cell lines in vitro using fluorescent molecularly imprinted polymers
- 2021
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Ingår i: Applied Sciences. - : MDPI. - 2076-3417. ; 11:7
-
Tidskriftsartikel (refereegranskat)abstract
- Sialylations are post-translational modifications of proteins and lipids that play important roles in many cellular events, including cell-cell interactions, proliferation, and migration. Tumor cells express high levels of sialic acid (SA), which are often associated with the increased invasive potential in clinical tumors, correlating with poor prognosis. To overcome the lack of natural SA-receptors, such as antibodies and lectins with high enough specificity and sensitivity, we have used molecularly imprinted polymers (MIPs), or “plastic antibodies”, as nanoprobes. Because high expression of epithelial cell adhesion molecule (EpCAM) in primary tumors is often associated with proliferation and a more aggressive phenotype, the expression of EpCAM and CD44 was initially analyzed. The SA-MIPs were used for the detection of SA on the cell surface of breast cancer cells. Lectins that specifically bind to the a-2,3 SA and a-2,6 SA variants were used for analysis of SA expression, with both flow cytometry and confocal microscopy. Here we show a correlation of EpCAM and SA expression when using the SA-MIPs for detection of SA. We also demonstrate the binding pattern of the SA-MIPs on the breast cancer cell lines using confocal microscopy. Pre-incubation of the SA-MIPs with SA-derivatives as inhibitors could reduce the binding of the SA-MIPs to the tumor cells, indicating the specificity of the SA-MIPs. In conclusion, the SA-MIPs may be a new powerful tool in the diagnostic analysis of breast cancer cells.
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| 37. |
- Ellonen, Hanna-Kaisa, et al.
(författare)
-
Entrepreneurial Heuristics During Crisis : How and Why Do Restaurateurs Make Decisions During Covid-19?
- 2021
-
Konferensbidrag (refereegranskat)abstract
- ObjectivesThe current Covid-19 pandemic has confronted the hospitality industry with an unprecedented challenge. The corona crisis provides an exceptional platform to further our understanding on how entrepreneurs operate under extreme uncertainty. We adopt an exploratory qualitative approach to study the decision-making heuristics Finnish restaurant entrepreneurs have used during a time of external crisis. More specifically we ask ourselves 1) how do entrepreneurs come to the decisions made, i.e. their decision making heuristics? and 2) what is the underlying logic of that rational?Prior workDecision making in the context of entrepreneurial action and uncertainty is largely covered in the effectuation framework, which outlines principles employed by experienced entrepreneurs when starting new firms and/or creating new markets. The corona crises offers a unique opportunity to study effectuation under absolute uncertainty and with unpredictable temporal dynamics.ApproachWe interviewed 11 restaurateurs in Helsinki and using a thinking aloud -protocol we analyseddecision-makers’ cognitive processes, priorities and related actions for a period of one year, starting from thecommencement of Finland’s first national Covid-19 lockdown in March 2020 and lasting until March 2021.ResultsThe 11 entrepreneurs differed considerably in terms of their use of effectual and causal logics despite their seemingly similar backgrounds and business context. In order to understand the decision-making logic of the entrepreneurs, two other aspects appear pivotal: first, the entrepreneurs’ time horizon and second, an additional set of pre-heuristics rooted in the entrepreneur’s personal beliefs and values used to steer the direction of future decisions.Implications and valueThe main contribution of the present study for the entrepreneurship research field is the identification of three separate heuristics used by entrepreneurs during a temporal crisis: 1) creating opportunities responding to personal values, 2) pragmatic action and 3) preserving business values. Both the first and third are strongly linked to values; the first to the personal values of the entrepreneur and the third to the business values of the enterprise.
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| 38. |
- Ellonen, Hanna-Kaisa, et al.
(författare)
-
Magazine management : Publishing as a business
- 2015
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Ingår i: The Routledge Handbook of Magazine Research. - New York : Routledge. - 9781138854161
-
Bokkapitel (refereegranskat)abstract
- Magazine management as a field of study lies within the area of Media Management and Economics (MME). MME research is producing a growing body of literature focusing on economic, management and business issues in the media industries, based largely on traditional concepts and theories in the two related disciplines of management and economics. Study of media management and economics has grown in stature since the 1990s pioneering works of Robert Picard and Alan Albarran. Several seminal books have been published in the 2000s, including the Handbook of Media Management and Economics and Annet Aris and Jacques Bughin’s Managing Media Companies. The founding of three academic journals, namely the Journal of Media Economics (in 1988), the International Journal of Media Management (in 1999), and the Journal of Media Business Studies (in 2007), has established the field by providing industry-specific publication outlets for research on journalism and media-based business and economics.This chapter comprises a review of the current research on the magazine industry, segmented in the following five categories: media economics, management research, business modeling, innovation and brand management. These categories reflect the main body of research related to magazines and magazine publishing from a business perspective. Research specific to magazine publishing is scarce in comparison with that in other media sectors, such as the newspaper industry. However, a strength is that the body of magazine-related research includes both global and digital studies, with theory and applications continuing to mature. Included in this review is management research that focuses on magazine publishers, as well as research in which magazine publishing is the empirical context for a larger theoretical approach.
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| 39. |
- Ellonen, Hanna-Kaisa, et al.
(författare)
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Simple rules and learning : Business model innovation during Covid-19
- 2021
-
Ingår i: ISPIM Innovation Conference 2021. - 9789523356917
-
Konferensbidrag (refereegranskat)abstract
- The COVID-19 pandemic has presented the hospitality industry with novel challenges. In this paper, we follow four case restaurants for a period of 12 months and track how they have innovated their business models and their learning processes through several cycles of iteration. Our work is based on the notion of simple rules. Eisenhardt and Sull (2001) propose simple rules as an approach to help businesses make decisions under fast-changing and uncertain environments. Methodologically, our study is a comparative case study with data comprising of interviews (two rounds in 2020 and 2021) and secondary data such as newspaper articles, web articles, restaurant websites and social media validating the timelines. Our results reveal that each of the case companies has 2-3 simple rules that have been pivotal for their business model innovation, and that these simple rules have become more explicit through different learning mechanisms.
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| 40. |
- Ellonen, Hanna-Kaisa, et al.
(författare)
-
The interplay of dominant logic and dynamic capabilities in innovation activities
- 2015
-
Ingår i: International Journal of Innovation Management. - : Imperial College Press. - 1363-9196 .- 1757-5877. ; 19:5, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Within the strategic management literature, both managerial cognition and dynamic capabilities have been identified as drivers of change and transition in changing business environments. The purpose of this study is to explore the interplay of dominant logic and dynamic capabilities in the magazine publishing industry. We investigated four magazine publishing business units of a large media corporation situated in four different countries, namely Finland, the Netherlands, Hungary and Russia. A total of 40 magazine managers were interviewed. The results imply that dominant logic and dynamic capabilities coevolve in a reciprocal relationship, and the interplay of cognition and capabilities seems to be most visible in the seizing and reconfiguring capabilities. The results of the present study also illustrate that there may be several contradictory dominant logics within a single company. Dynamic capabilities useful to innovation processes are developed in the areas that are pinpointed by the managers as the locus of attention. Industry transition does not automatically change what companies think and do. That requires managerial attention and an active reconceptualization of the business and active development of not only day-to-day operations, but capabilities needed to change the way we work.
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| 41. |
- Ellonen, Hanna-Kaisa, et al.
(författare)
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The role of the website in a magazine business – revisiting old truths
- 2015
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Ingår i: Journal of Media Business Studies. - : Taylor & Francis Group. - 1652-2354 .- 2376-2977. ; 12:4, s. 238-249
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores consumer behavioural patterns on a magazine website. By using a unique dataset of real-life click stream data from 295 magazine website visitors, interesting behavioural patterns are noted: most importantly, 86% of all sessions only visit the blogs hosted by the magazine. This means that the visitors short-circuit the start page and are not exposed to any editorial content at all, and consequently not to any commercial content on those pages. Sessions visiting editorial content, commercial content or social media links actually represent only 1% or less of all sessions recorded. Consequently, the online platform gives very limited support for the business model. Our data questions the general assumption that online platforms are key components of a contemporary magazine’s business model.
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| 42. |
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| 43. |
- Emilson, Anette, 1964-
(författare)
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Det önskvärda barnet : Fostran uttryckt i vardagliga kommunikationshandlingar mellan lärare och barn i förskolan
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this research is to acquire knowledge about fostering young children, as expressed in everyday interactions between teachers and children in Swedish preschools. The three empirical studies in this doctoral thesis investigated partly specific democratic values such as participation and influence and partly the values that teachers explicitly or implicitly encourage and how these values are communicated to children. The thesis takes a critical approach in order to also acquire knowledge about important fostering aspects that can move hierarchal power structures towards a fostering of values characterized by intersubjectivity. In order to understand the interactions, the concepts of communicative and strategic action (Habermas, 1984) are used, as well as strong and weak classification and framing (Bernstein, 2000). Preschool fostering is also analyzed from a double perspective, with a starting-point in Habermas’ (1984, 1995a) concepts of the system and the life-world. The fieldwork took place with three different groups of toddlers in Swedish preschools. Forty-six children (aged 1 to 3 years) participated, as well as their ten teachers. The data consisted of videotaped observations of teacher and child interactions. The first study investigated how a toddler’s participation can be understood in two kinds of educational activities where the degree of teacher control differs. The results showed how strong classification and framing risk restricting children’s participation and how a weak classification and framing can promote children’s opportunities to participate on their own terms. Important issues for children’s participation were found to be a participant teacher who creates meaningful contexts, where teacher control is about being emotionally present, supportive and responsive. The purpose of the second study was to investigate how very young children can exert an influence in circle-time situations in relation to teacher control. The results showed that the children do, in fact, make choices, mostly based on several fixed alternatives, and that they do take the initiative, sometimes to express an opinion or a right, sometimes to express what they want to do in circle time. It was also found that the influence young children are able to exert varies with the control the teacher exercises. It is evident that strong teacher control is maintained in different ways and that strong control does not necessarily limit children’s influence; it depends on the nature of the control. Children’s influence increases when the teacher’s control over the what and how aspects of communications is weak, and is characterized by closeness to the child’s life-world and a communicative approach. The third study examined the values that teachers explicitly or implicitly encourage and how these values are communicated to children. The analyses resulted in ten specific values embedded in value dimensions of discipline, caring and democracy. These, in turn, can be divided into different social orientations – both collective and individualistic. The values are communicated differently and the what aspect of the communication (the value) is interrelated with the how aspect of the communication; how teachers communicate influences and sometimes changes the communicated value. In order to change power structures in teacher and child interactions, three aspects of importance have been identified: teachers’ closeness to the child’s perspective, their emotional presence and playfulness. Theoretically, the aspects are within the framework of communicative action and contribute to the understanding of what the theory might mean in communication with the youngest children in the educational system.
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| 44. |
- Emilson, Anette, 1964-, et al.
(författare)
-
Kommunikation af værdier til born
- 2012
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Ingår i: <em>Forskning i pædagogisk praksis</em>. - Køpenhavn : Akademisk Forlag. - 9788750042877 ; , s. 204-229
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 45. |
- Emilson, Anette, 1964-, et al.
(författare)
-
Participation and gender in circle-time situations in pre-school
- 2013
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Ingår i: International Journal of Early Years Education. - : Informa UK Limited. - 0966-9760 .- 1469-8463. ; 21:1, s. 56-69
-
Tidskriftsartikel (refereegranskat)abstract
- This study sought to investigate participatory values in relation to gender, asexpressed in interactions between teachers and children in circle-time situations inSwedish and Norwegian preschools. This paper reports evidence from threeresearch questions: How is children’s participation conditioned in circle-timesituations? How are participatory values communicated to girls and boys? andWhat gender-related patterns emerge in teacherchild interactions in circletimesituations? The study is informed by Habermas’ concepts of strategic andcommunicative actions, as well as Davies’ idea of duality, the bi-polarity, betweenfemininity and masculinity. Data consist of video observations of teacher andchild interactions during circle time. The results show that children’s participationis conditional on children’s own willingness to participate, and on teachers’willingness to involve the children in a communicative action. Data reveal that thegirls are more likely to take the initiative than boys and appear more comfortable insuch an active position. It was also noted that there is a tendency for practitioners tointerpret and value male and female traits as oppositional behaviours.
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| 46. |
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| 47. |
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| 48. |
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| 49. |
- Emilson, Anette, 1964-, et al.
(författare)
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Values in Nordic early childhood education : democracy and the child’s perspective
- 2018
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Ingår i: International Handbook of Early Childhood Education. - Dordrecht : Springer. - 9789402409253 - 9789402409277 ; , s. 929-954
-
Bokkapitel (refereegranskat)abstract
- The aim of this chapter is to outline and discuss the development of Nordic research on democracy in the field of early childhood education and care (ECEC). We will show how research over a relatively short time has altered from normative and political arguments for democracy in ECEC via an interest in how to implement and operationalize democratic ideas into practice, leading towards a more critical approach addressing complexity to democracy. Through this process a new concept of democracy connected with shared life and pluralism appears to emerge. Communication becomes important. In turn, ambiguity and even conflicting ideas appears to be accepted as a base for democracy.
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| 50. |
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