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Träfflista för sökning "WFRF:(Johansson Hagslatt Marie Louise) "

Sökning: WFRF:(Johansson Hagslatt Marie Louise)

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1.
  • Ahrné, Siv, et al. (författare)
  • Effect of lactobacilli on paracellular permeability in the gut.
  • 2011
  • Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 3:1, s. 104-117
  • Tidskriftsartikel (refereegranskat)abstract
    • Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells.
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2.
  • Wullt, Marlene, et al. (författare)
  • Lactobacillus plantarum 299v Enhances the Concentrations of Fecal Short-Chain Fatty Acids in Patients with Recurrent Clostridium difficile-Associated Diarrhea.
  • 2007
  • Ingår i: Digestive Diseases and Sciences. - : Springer Science and Business Media LLC. - 1573-2568 .- 0163-2116. ; 52, s. 2082-2086
  • Tidskriftsartikel (refereegranskat)abstract
    • Our objective was to document how intake of Lactobacillus plantarum 299v affects the concentrations of fecal organic acids during and after metronidazole treatment in 19 patients with recurrent Clostridium difficile-associated diarrhea. Fecal samples were analyzed by gas-liquid chromatography. After intake of metronidazole a significant decrease in total short-chain fatty acids was seen in the placebo group (from 77.1 to 45.5 mu mol/g; P=0.028) but not in the Lactobacillus group (79.8-60.4 mu mol/g). In addition, a statistically significant difference between treatment groups was noted for butyrate (5.6-1.2 mu mol/g in the placebo group vs. 7.6-5.6 mu mol/g in the Lactobacillus group; P=0.047). At the end of the study and after cessation of placebo or Lactobacillus, the total short-chain fatty acids rose to the same levels as before antibiotic treatment in the placebo group. Both treatment groups showed a significant decrease in concentrations of succinate at the end of the study in comparison to the time when metronidazole intake was stopped (6.3-1.5 mu mol/g in the placebo group versus 9.3-0.9 mu mol/g in the Lactobacillus group; P=0.028). The present study of fecal samples from a clinical trial is the first to demonstrate that administration of Lactobacillus plantarum 299v reduces the negative effects of an antibiotic on colonic fermentation. The intake of this probiotic strain may thereby provide an additional benefit for patients with recurrent Clostridium difficile-associated diarrhea.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
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Johansson Hagslatt, ... (2)
Ahrné, Siv (1)
Odenholt, Inga (1)
Berggren, Anna (1)
Wullt, Marlene (1)
Lärosäte
Lunds universitet (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

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