| 1. |
- Bamia, Christina, et al.
(författare)
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Dietary patterns and survival of older Europeans : the EPIC-Elderly Study (European Prospective Investigation into Cancer and Nutrition)
- 2007
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Ingår i: Public Health Nutrition. - : Cambridge University Press. - 1368-9800 .- 1475-2727. ; 10:6, s. 590-598
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate the association of a posteriori dietary patterns with overall survival of older Europeans.Design and setting: This is a multi-centre cohort study. Cox regression analysis was used to investigate the association of the prevailing, a posteriori-derived, plant-based dietary pattern with all-cause mortality in a population of subjects who were 60 years or older at recruitment to the European Prospective Investigation into Cancer and Nutrition (EPIC-Elderly cohort). Analyses controlled for all known potential risk factors.Subjects: In total, 74 607 men and women, 60 years or older at enrolment and without previous coronary heart disease, stroke or cancer, with complete information about dietary intakes and potentially confounding variables, and with known survival status as of December 2003, were included in the analysis.Results: An increase in the score which measures the adherence to the plant-based diet was associated with a lower overall mortality, a one standard deviation increment corresponding to a statistically significant reduction of 14% (95% confidence interval 5–23%). In country-specific analyses the apparent association was stronger in Greece, Spain, Denmark and The Netherlands, and absent in the UK and Germany.Conclusions: Greater adherence to the plant-based diet that was defined a posteriori in this population of European elders is associated with lower all-cause mortality. This dietary score is moderately positively correlated with the Modified Mediterranean Diet Score that has been constructed a priori and was also shown to be beneficial for the survival of the same EPIC-Elderly cohort.
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| 2. |
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| 3. |
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Brodowski, W, et al.
(författare)
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Two-Pion Production in Nucleon-Nucleon Collisions
- 2002
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Ingår i: Proc. Int. Conf. on Production, Properties and Interaction of Mesons, MESON 2002, Cracow, Poland, 2002..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Johansson, Anders, et al.
(författare)
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Prevalence of systemic immunoreactivity to Aggregatibacter actinomycetemcomitans leukotoxin in relation to the incidence of myocardial infarction
- 2011
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Ingår i: BMC Infectious Diseases. - : BioMed Central. - 1471-2334. ; 11:1, s. 55-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chronic infections and associated inflammatory markers are suggested risk factors for cardiovascular disease (CVD). The proinflammatory cytokine, interleukin (IL)-1, is suggested to play a role in the regulation of local inflammatory responses in both CVD and periodontitis. The leukotoxin from the periodontal pathogen Aggregatibacter actinomycetemcomitans has recently been shown to cause abundant secretion of IL-1 from macrophages. The aim of the present study was to compare the prevalence of systemic immunoreactivity to A. actinomycetemcomitans leukotoxin in myocardial infarction (MI) cases (n=532) and matched controls (n=1000) in a population-based case and referents study in northern Sweden. Methods: Capacity to neutralize A. actinomycetemcomitans leukotoxin was analyzed in a bioassay with leukocytes, purified leukotoxin, and plasma. Plasma samples that inhibited lactate-dehydrogenase release from leukotoxin-lysed cells by 50 % were classified as positive. Results: Neutralizing capacity against A. actinomycetemcomitans leukotoxin was detected in 53.3% of the plasma samples. The ability to neutralize leukotoxin correlated to increasing age in men (n=1082) but not in women (n=450). There was no correlation between presence of systemic leukotoxin neutralization capacity and the incidence of MI, except for women (n=146). Women with a low neutralizing capacity had a significantly higher incidence of MI than those who had a high neutralizing capacity. Conclusions: Systemic immunoreactivity against A. actinomycetemcomitans leukotoxin was found at a high prevalence in the analyzed population of adults from northern Sweden. The results from the present study do not support the hypothesis that systemic leukotoxin-neutralizing capacity can decrease the risk for MI.
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| 9. |
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| 10. |
- Pätzold, Jens, et al.
(författare)
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Exclusive measurements of the pp --> pp pi+pi- reaction
- 2002
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Ingår i: Proc. 9th Int. Symp. on Meson-Nucleon Physics and the Structure of the Nucleon, MENU 2001, Washington D.C., USA, 2001., piN Newsletter. ; , s. 370-
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Konferensbidrag (refereegranskat)
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Adler, Mark, et al.
(författare)
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A SINGULAR TOEPLITZ DETERMINANT AND THE DISCRETE TACNODE KERNEL FOR SKEW-AZTEC RECTANGLES
- 2022
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Ingår i: The Annals of Applied Probability. - : Institute of Mathematical Statistics. - 1050-5164 .- 2168-8737. ; 32:2, s. 1234-1294
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Tidskriftsartikel (refereegranskat)abstract
- Random tilings of geometrical shapes with dominos or lozenges have been a rich source of universal statistical distributions. This paper deals with domino tilings of checker board rectangular shapes such that the top two and bottom two adjacent squares have the same orientation and the two most left and two most right ones as well. It forces these so-called "skew-Aztec rectangles" to have cuts on either side. For large sizes of the domain and upon an appropriate scaling of the location of the cuts, one finds split tacnodes between liquid regions with two distinct adjacent frozen phases descending into the tacnode. Zooming about such split tacnodes, filaments appear between the liquid patches evolving in a bricklike sea of dimers of another type. This work shows that the random fluctuations in a neighborhood of the split tacnode are governed asymptotically by the discrete tacnode kernel, providing strong evidence that this kernel is a universal discrete-continuous limiting kernel occurring naturally whenever we have doubly interlacing patterns. The analysis involves the inversion of a singular Toeplitz matrix which leads to considerable difficulties.
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| 16. |
- Adler, Mark, et al.
(författare)
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Double Aztec diamonds and the tacnode process
- 2014
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Ingår i: Advances in Mathematics. - : Elsevier BV. - 0001-8708 .- 1090-2082. ; 252, s. 518-571
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Tidskriftsartikel (refereegranskat)abstract
- Discrete and continuous non-intersecting random processes have given rise to critical "infinite-dimensional diffusions", like the Airy process, the Pearcey process and variations thereof. It has been known that domino tilings of very large Aztec diamonds lead macroscopically to a disordered region within an inscribed ellipse (arctic circle in the homogeneous case), and a regular brick-like region outside the ellipse. The fluctuations near the ellipse, appropriately magnified and away from the boundary of the Aztec diamond, form an Airy process, run with time tangential to the boundary. This paper investigates the domino tiling of two overlapping Aztec diamonds; this situation also leads to non-intersecting random walks and an induced point process; this process is shown to be determinantal. In the large size limit, when the overlap is such that the two arctic ellipses for the single Aztec diamonds merely touch, a new critical process will appear near the point of osculation (tacnode), which is run with a time in the direction of the common tangent to the ellipses: this is the tacnode process. It is also-shown here that this tacnode process is universal: it coincides with the one found in the context of two groups of non-intersecting random walks or also Brownian motions, meeting momentarily.
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| 17. |
- Adler, Mark, et al.
(författare)
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Lozenge Tilings of Hexagons with Cuts and Asymptotic Fluctuations : a New Universality Class
- 2018
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Ingår i: Mathematical physics, analysis and geometry. - : Springer. - 1385-0172 .- 1572-9656. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates lozenge tilings of non-convex hexagonal regions and more specifically the asymptotic fluctuations of the tilings within and near the strip formed by opposite cuts in the regions, when the size of the regions tend to infinity, together with the cuts. It leads to a new kernel, which is expected to have universality properties.
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| 18. |
- Adler, M., et al.
(författare)
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Tacnode GUE-minor processes and double Aztec diamonds
- 2015
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Ingår i: Probability theory and related fields. - : Springer Science and Business Media LLC. - 0178-8051 .- 1432-2064. ; 162:1-2, s. 275-325
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Tidskriftsartikel (refereegranskat)abstract
- We study determinantal point processes arising in random domino tilings of a double Aztec diamond, a region consisting of two overlapping Aztec diamonds. At a turning point in a single Aztec diamond where the disordered region touches the boundary, the natural limiting process is the GUE-minor process. Increasing the size of a double Aztec diamond while keeping the overlap between the two Aztec diamonds finite, we obtain a new determinantal point process which we call the tacnode GUE-minor process. This process can be thought of as two colliding GUE-minor processes. As part of the derivation of the particle kernel whose scaling limit naturally gives the tacnode GUE-minor process, we find the inverse Kasteleyn matrix for the dimer model version of the Double Aztec diamond.
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| 19. |
- Adler, Mark, et al.
(författare)
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Tilings of Non-convex Polygons, Skew-Young Tableaux and Determinantal Processes
- 2018
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Ingår i: Communications in Mathematical Physics. - : Springer. - 0010-3616 .- 1432-0916. ; 364:1, s. 287-342
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Tidskriftsartikel (refereegranskat)abstract
- This paper studies random lozenge tilings of general non-convex polygonal regions. We show that the pairwise interaction of the non-convexities leads asymptotically to new kernels and thus to new statistics for the tiling fluctuations. The precise geometrical figure here consists of a hexagon with cuts along opposite edges. For this model, we take limits when the size of the hexagon and the cuts tend to infinity, while keeping certain geometric data fixed in order to guarantee sufficient interaction between the cuts in the limit. We show in this paper that the kernel for the finite tiling model can be expressed as a multiple integral, where the number of integrations is related to the fixed geometric data above. The limiting kernel is believed to be a universal master kernel.
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| 20. |
- Agréus, Lars, et al.
(författare)
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Predictors and non-predictors of symptom relief in dyspepsia consultations in primary care
- 2008
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Ingår i: Digestive Diseases. - : S. Karger AG. - 0257-2753 .- 1421-9875. ; 26:3, s. 248-255
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: We aimed to evaluate if the course of dyspepsia is influenced by medical consultation in primary care. DESIGN, SETTING AND PATIENTS: Australian general practitioners (n = 27) recruited 157 dyspeptic patients, of whom 94 were eligible for follow-up. Dyspepsia, comorbidity, quality of life, emotional status, locus of control and consultation satisfaction were measured at baseline and follow-up (mean 3 months). MAIN OUTCOME MEASURE: Response was defined as improvement of dyspepsia over time on the Nepean Dyspepsia Index score. RESULTS: Dyspepsia improved in 82% (n = 77). There was no significant change in non-gastrointestinal symptoms. Half were worried or stressed by their symptoms, and 85% wanted reassurance, a need that (univariately) differentiated responders from non-responders (p = 0.02). Most patients seen in primary care with dyspepsia improved. If the doctor believed it was likely that the patient would follow their recommendations, the patient was nearly five times as likely to be a responder (OR 4.9, 95% CI 1.2-19.0). The only other significant predictor was acid suppression therapy (OR 3.5, 95% CI 1.1-10.9). CONCLUSION: Most primary care visits for dyspepsia are followed by improvement, which may be predicted in part by indicators of patient compliance. Prescription of acid suppression therapy may also improve outcome in dyspepsia
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| 21. |
- Andersson, Jonas, 1977-, et al.
(författare)
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C-reactive protein is a determinant of first-ever stroke: prospective nested case-referent study.
- 2009
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Ingår i: Cerebrovascular diseases (Basel, Switzerland). - : S. Karger AG. - 1421-9786 .- 1015-9770. ; 27:6, s. 544-51
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: C-reactive protein (CRP) is a determinant of stroke, but there are no prospective studies on CRP and first ischemic stroke divided into etiologic subtypes. Our primary aim was to study CRP as a determinant of ischemic stroke, classified according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria, and intracerebral hemorrhage (ICH) in a prospective study. A secondary aim was to study the relationship between the 1444C>T polymorphism, plasma levels of CRP and stroke. METHODS: The study was a prospective population-based case-referent study nested within the Northern Sweden Cohorts. We defined 308 cases of ischemic stroke and 61 ICH. Two controls for each case were defined from the same cohort. RESULTS: The OR for the highest (>3 mg/l) versus lowest group (<1 mg/l) of CRP was 2.58 (95% CI 1.74-3.84) for ischemic stroke and 1.63 (95% CI 0.67-3.93) for ICH. In a multivariate model including traditional risk factors, CRP remained associated with ischemic stroke (OR 2.06; 95% CI 1.29-3.29). Small-vessel disease was associated with CRP in the multivariate model (OR 3.88; 95% CI 1.10-13.7). The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP but neither with ischemic stroke nor with ICH. CONCLUSIONS: This prospective population-based study shows that CRP is significantly associated with the risk of having a first ischemic stroke, especially for small-vessel disease. No significant associations were found between the CRP 1444C>T polymorphism and any stroke subtype.
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| 22. |
- Andersson, Jonas, 1977-
(författare)
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Inflammation and lifestyle in cardiovascular medicine
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Despite major advances in the treatment and prevention of atherosclerosis the last several decades, cardiovascular disease still accounts for the majority of deaths in Sweden. With the population getting older, more obese and with rising numbers of diabetics, the cardiovascular disease burden may increase further in the future. The focus in cardiovascular disease has shifted with time from calcification and narrowing of arteries to the biological processes within the atherosclerotic plaque. C-reactive protein (CRP) has emerged as one of many proteins that reflect a low grade systemic inflammation and is suitable for analysis as it is more stable and easily measured than most other inflammatory markers. Several large prospective studies have shown that CRP is not only an inflammatory marker, but even a predictive marker for cardiovascular disease. C-reactive protein is associated with several other risk factors for cardiovascular disease including obesity and the metabolic syndrome. Our study of twenty healthy men during a two week endurance cross country skiing tour demonstrated a decline in already low baseline CRP levels immediately after the tour and six weeks later. In a study of 200 obese individuals with impaired glucose tolerance randomised to a counselling session at their health care centre or a one month stay at a wellness centre, we found decreased levels of CRP in subjects admitted to the wellness centre. The effect remained at one, but not after three years of follow-up. In a prospective, nested, case-referent study with 308 ischemic strokes, 61 intracerebral haemorrhages and 735 matched referents, CRP was associated with ischemic stroke in both uni- and multivariate analyses. No association was found with intracerebral haemorrhages. When classifying ischemic stroke according to TOAST criteria, CRP was associated with small vessel disease. The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP, but neither with ischemic stroke nor with intracerebral haemorrhage. A study on 129 patients with atrial fibrillation was used to evaluate whether inflammation sensitive fibrinolytic variables adjusted for CRP could predict recurrence of atrial fibrillation after electrical cardioversion. In multivariate iv models, lower PAI-1 mass was associated with sinus rhythm even after adjusting for CRP and markers of the metabolic syndrome. In conclusion, lifestyle intervention can be used to reduce CRP levels, but it remains a challenge to maintain this effect. CRP is a marker of ischemic stroke, but there are no significant associations between the CRP1444 polymorphism and any stroke subtype, suggesting that the CRP relationship with ischemic stroke is not causal. The fibrinolytic variable, PAI-1, is associated with the risk of recurrence of atrial fibrillation after electrical cardioversion after adjustment for CRP. Our findings suggest a pathophysiological link between atrial fibrillation and PAI-1, but the relation to inflammation remains unclear.
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| 23. |
- Andersson, Leif, et al.
(författare)
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Inventering av violgubbe (Gomphus clavatus) och rödlistade fjälltaggsvampar (Sarcodon spp.) i Västmanlands län 2008.
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna inventering av violgubbe (Gomphus clavatus) och rödlistade fjälltaggsvampar (Sarcodon spp.) har utförts på uppdrag av Länsstyrelsen i Västmanlands län. Syftet har varit att öka kunskapen om arternas förekomst i länet samt behovet av skydd och andra åtgärder på de olika lokalerna. Inventeringen har genomförts inom ramen för åtgärdsprogrammen (ÅGP) för bevarande av violgubbe och rödlistade fjälltaggsvampar. Inventeringen har genomförts under september 2008 av Leif Andersson, Kurt- Anders Johansson, Rolf-Göran Carlsson, Stig Jacobsson och Tomas Fasth. Alla kända lokaler för violgubbe och rödlistade fjälltaggsvampar besöktes. Även lokaler för arter med likartade miljökrav har besökts och områden kända för kalkrik berggrund. Under inventeringen har mycel för de eftersökta arterna noterats och koordinater för dessa tagits. Även andra svampar har noterats om än i olika omfattning. Totalt har ett hundratal lokaler besökts varav svampar har noterats på 80 lokaler. Säsongen var mycket god för fjälltaggsvampar, möjligen med undantag för brödtaggsvamp (Sarcodon versipellis). För violgubbe var säsongen något sämre. Totalt noterades violgubbe och/eller rödlistade fjälltaggsvampar på 17 lokaler. Av de 19 kända lokalerna för violgubbe noterades den på sex och en ny lokal upptäcktes. Tidigare var 20 lokaler kända för de olika rödlistade fjälltaggsvamparna varav återfynd gjordes på sex av dessa. Dessutom gjordes 14 nya fynd av rödlistade fjälltaggvampar. Nya för Västmanlands län är blåfotad taggsvamp (Sarcodon glaucopus), sammetstaggsvamp (Sarcodon martioflavus) och den ännu obeskrivna Sarcodon ”modestum”. Den goda svamptillgången 2008 gjorde att särskilt många rödlistade spindelskivlingar noterades. Flera arter är nya för Västmanlands län. Även andra nyfynd av rödlistade svampar för Västmanlands län gjordes t. ex. narrvaxskivlingen (Hygrophorus subviscifer) som noterades på två platser. Totalt gjordes 146 fynd av 42 rödlistade svampar inklusive violgubbe och rödlistade fjälltaggsvampar. Ett antal lokaler och områden har kristalliserats ut som särskilt intressanta för de eftersökta svamparna. I Sala kommun finns många värdefulla områden, särskilt nära tätorten, ofta i närheten av där gruvdrift bedrivits. Särskilt Snarpsätraskogen norr om staden samt områden söder och sydväst om staden hyste många hotade arter. Områdena söder om staden ingår i Salakalkens Natura 2000-område, men skogsnaturtyperna är i dagsläget inte anmälda som naturtyp. I Fagersta och Norberg finns också värdefulla stråk för violgubbe och rödlistade fjälltaggsvampar. Särskilt ska här framhållas Jättåsarna i Fagersta kommun. Flera områdena är inte utpekade som naturvärden eller nyckelbiotoper och saknar också formellt områdesskydd. Ett antal lokaler för de eftersökta svamparna finns i naturreservat och biotopskydd.
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| 24. |
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| 25. |
- Ayyer, Arvind, et al.
(författare)
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Goe fluctuations for the maximum of the top path in alternating sign matrices
- 2023
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Ingår i: Duke mathematical journal. - : Duke University Press. - 0012-7094 .- 1547-7398. ; 172:10, s. 1961-2014
-
Tidskriftsartikel (refereegranskat)abstract
- The six-vertex model is an important toy-model in statistical mechanics for twodimensional ice with a natural parameter A. When A = 0, the so-called free-fermion point, the model is in natural correspondence with domino tilings of the Aztec diamond. Although this model is integrable for all A, there has been very little progress in understanding its statistics in the scaling limit for other values. In this work, we focus on the six-vertex model with domain wall boundary conditions at A = 1/2, where it corresponds to alternating sign matrices (ASMs). We consider the level lines in a height function representation of ASMs. We show that the maximum of the topmost level line for a uniformly random ASMs has the Gaussian orthogonal ensemble (GOE) Tracy-Widom distribution after appropriate rescaling. A key ingredient in our proof is Zeilberger's proof of the ASM conjecture. As far as we know, this is the first edge fluctuation result away from the tangency points for the domain-wall six-vertex model when we are not in the free-fermion case.
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| 26. |
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| 27. |
- Bardel, Annika, 1952-, et al.
(författare)
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Age and sex related self-reported symptoms in a general population across 30 years: Patterns of reporting and secular trend
- 2019
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- Objective :To study age and sex specific prevalence of 30 symptoms in random samples from the general population and to analyze possible secular trends across time. Study population: The study was based on data from eight on-going Swedish cohort studies, with baseline investigations performed between 1973 and 2003. Samples were drawn from the general population of the cities of Gothenburg and Eskilstuna, and of Uppsala County. Overall, 20,160 subjects were sampled, 14,470 (71.8%) responded, of whom 12.000 were unique subjects, and 2548 were part of more than one sample. Methods: The Complaint score sub-scale of the Gothenburg Quality of Life instrument, listing 30 general symptoms was used. Responders were asked to indicate which symptoms they had experienced during the last three months. Results: Women reported on average 7.8 symptoms, and men 5.3 (p<0.0001). Women reported higher prevalence than men for 24 of the 30 symptoms. In multivariate analyses four patterns of prevalence across age were identified in both men and women; increasing prevalence, decreasing, stable and biphasic prevalence. The symptoms in the various pattern groups differed somewhat between men and women. However, symptoms related to strain were prominent among symptoms decreasing with age. Moreover, there were secular trends. Across all symptoms reporting prevalence increased over time in men (p<0.001) as well as in women (p<0.0001). Conclusions: Women reported higher total symptom prevalence than men. Symptoms related to health generally increased with age, while symptoms related to stress decreased markedly. Significant secular trends across time regarding symptom prevalence were found. © 2019 Bardel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| 28. |
- Beffara, Vincent, et al.
(författare)
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AIRY POINT PROCESS AT THE LIQUID-GAS BOUNDARY
- 2018
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Ingår i: Annals of Probability. - : Institute of Mathematical Statistics. - 0091-1798 .- 2168-894X. ; 46:5, s. 2973-3013
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Tidskriftsartikel (refereegranskat)abstract
- Domino tilings of the two-periodic Aztec diamond feature all of the three possible types of phases of random tiling models. These phases are determined by the decay of correlations between dominoes and are generally known as solid, liquid and gas. The liquid-solid boundary is easy to define microscopically and is known in many models to be described by the Airy process in the limit of a large random tiling. The liquid-gas boundary has no obvious microscopic description. Using the height function, we define a random measure in the two-periodic Aztec diamond designed to detect the long range correlations visible at the liquid-gas boundary. We prove that this random measure converges to the extended Airy point process. This indicates that, in a sense, the liquid-gas boundary should also be described by the Airy process.
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| 29. |
- Beffara, Vincent, et al.
(författare)
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LOCAL GEOMETRY OF THE ROUGH-SMOOTH INTERFACE IN THE TWO-PERIODIC AZTEC DIAMOND
- 2022
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Ingår i: The Annals of Applied Probability. - : Institute of Mathematical Statistics. - 1050-5164 .- 2168-8737. ; 32:2, s. 974-1017
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Tidskriftsartikel (refereegranskat)abstract
- Random tilings of the two-periodic Aztec diamond contain three macroscopic regions: frozen, where the tilings are deterministic; rough, where the correlations between dominoes decay polynomially; smooth, where the correlations between dominoes decay exponentially. In a previous paper, the authors found that a certain averaging of height function differences at the rough-smooth interface converged to the extended Airy kernel point process. In this paper, we augment the local geometrical picture at this interface by introducing well-defined lattice paths which are closely related to the level lines of the height function. We show, after suitable centering and rescaling, that a point process from these paths converge to the extended Airy kernel point process provided that the natural parameter associated to the two-periodic Aztec diamond is small enough.
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| 30. |
- Bender, Martin, 1976-
(författare)
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Limit theorems for generalizations of GUE random matrices
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis consists of two papers devoted to the asymptotics of random matrix ensembles and measure valued stochastic processes which can be considered as generalizations of the Gaussian unitary ensemble (GUE) of Hermitian matrices H=A+A†, where the entries of A are independent identically distributed (iid) centered complex Gaussian random variables. In the first paper, a system of interacting diffusing particles on the real line is studied; special cases include the eigenvalue dynamics of matrix-valued Ornstein-Uhlenbeck processes (Dyson's Brownian motion). It is known that the empirical measure process converges weakly to a deterministic measure-valued function and that the appropriately rescaled fluctuations around this limit converge weakly to a Gaussian distribution-valued process. For a large class of analytic test functions, explicit formulae are derived for the mean and covariance functionals of this fluctuation process. The second paper concerns a family of random matrix ensembles interpolating between the GUE and the Ginibre ensemble of n x n matrices with iid centered complex Gaussian entries. The asymptotic spectral distribution in these models is uniform in an ellipse in the complex plane, which collapses to an interval of the real line as the degree of non-Hermiticity diminishes. Scaling limit theorems are proven for the eigenvalue point process at the rightmost edge of the spectrum, and it is shown that a non-trivial transition occurs between Poisson and Airy point process statistics when the ratio of the axes of the supporting ellipse is of order n -1/3.
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| 31. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 32. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 33. |
- Bergman, Ingvar, et al.
(författare)
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Health-adjusted neuropsychological test norms based on 463 older Swedish car drivers
- 2016
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 57:2, s. 93-107
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Tidskriftsartikel (refereegranskat)abstract
- There is a need for improved normative information in particular for older persons. The present study provides neuropsychological test norms on seven cognitive tests used in a sample representing the general older driving population, when uncontrolled and controlled for physical health. A group of 463 healthy Swedish car drivers, aged 65 to 84 years, participated in a medical and neuropsychological examination. The latter included tests of visual scanning, mental shifting, visual spatial function, memory, reaction time, selective attention, and simultaneous capacity. Hierarchical regression analyses demonstrated that, when uncontrolled for health, old age was associated with significant impairment on all seven tests. Education was associated with a significant advantage for all tests except most reaction time subtests. Women outperformed men on selective attention. Controlling for health did not consistently change the associations with education, but generally weakened those with age, indicating rises in normative scores of up to 0.36 SD (residual). In terms of variance explained, impaired health predicted on average 2.5%, age 2.9%, education 2.1% and gender 0.1%. It was concluded (1)that individual regression-based predictions of expected values have the advantage of allowing control for the impact of health on normative scores in addition to the adjustment for various demographic and performance-related variables and (2) that health-adjusted norms have the potential to classify functional status more accurately, to the extent that these norms diverge from norms uncontrolled for physical health.
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| 34. |
- Björck, Lena, 1959, et al.
(författare)
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Changes in Dietary Fat Intake and Projections for Coronary Heart Disease Mortality in Sweden: A Simulation Study
- 2016
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 11:8
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: In Sweden, previous favourable trends in blood cholesterol levels have recently levelled off or even increased in some age groups since 2003, potentially reflecting changing fashions and attitudes towards dietary saturated fatty acids (SFA). We aimed to examine the potential effect of different SFA intake on future coronary heart disease (CHD) mortality in 2025. METHODS: We compared the effect on future CHD mortality of two different scenarios for fat intake a) daily SFA intake decreasing to 10 energy percent (E%), and b) daily SFA intake rising to 20 E%. We assumed that there would be moderate improvements in smoking (5%), salt intake (1g/day) and physical inactivity (5% decrease) to continue recent, positive trends. RESULTS: In the baseline scenario which assumed that recent mortality declines continue, approximately 5,975 CHD deaths might occur in year 2025. Anticipated improvements in smoking, dietary salt intake and physical activity, would result in some 380 (-6.4%) fewer deaths (235 in men and 145 in women). In combination with a mean SFA daily intake of 10 E%, a total of 810 (-14%) fewer deaths would occur in 2025 (535 in men and 275 in women). If the overall consumption of SFA rose to 20 E%, the expected mortality decline would be wiped out and approximately 20 (0.3%) additional deaths might occur. CONCLUSION: CHD mortality may increase as a result of unfavourable trends in diets rich in saturated fats resulting in increases in blood cholesterol levels. These could cancel out the favourable trends in salt intake, smoking and physical activity.
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| 35. |
- Björkegren, Karin, et al.
(författare)
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General symptom reporting in female fibromyalgia patients and referents : a population-based case-referent study
- 2009
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Ingår i: BMC Public Health. - : BioMed Central. - 1471-2458. ; 9, s. 402-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Fibromyalgia is characterized by widespread musculoskeletal pain and palpation tenderness. In addition to these classic symptoms, fibromyalgia patients tend to report a number of other complaints. What these other complaints are and how often they are reported as compared with related referents from the general population is not very well known. We therefore hypothesized that subjects with fibromyalgia report more of a wide range of symptoms as compared with referents of the same sex and age from the general population. METHODS: 138 women with diagnosed fibromyalgia in primary health care and 401 referents from the general population matched to the cases by sex, age and residential area responded to a postal questionnaire where information on marital status, education, occupational status, income level, immigrant status, smoking habits physical activity, height and weight history and the prevalence of 42 defined symptoms was sought. RESULTS: The cases had lower educational and income levels, were more often unemployed, on sick leave or on disability pension and were more often first generation immigrants than the referents. They were also heavier, shorter and more often had a history of excessive food intake and excessive weight loss. When these differences were taken into account, cases reported not only significantly more presumed fibromyalgia symptoms but also significantly more of general symptoms than the referents. The distribution of symptoms was similar in subjects with fibromyalgia and referents, indicating a generally higher symptom reporting level among the former. CONCLUSION: Subjects with fibromyalgia had a high prevalence of reported general symptoms than referents. Some of these differences may be a consequence of the disorder while others may reflect etiological processes.
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| 36. |
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| 37. |
- Boeing, Heiner, et al.
(författare)
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Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study
- 2006
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 17:7, s. 957-969
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Tidskriftsartikel (refereegranskat)abstract
- Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (< 120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.
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| 38. |
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| 39. |
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| 40. |
- Boman, Kurt, et al.
(författare)
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Healthcare resource utilisation and costs associated with a heart failure diagnosis : A retrospective, population-based cohort study in Sweden
- 2021
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 11:10
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To examine healthcare resource use (HRU) and costs among heart failure (HF) patients using population data from Sweden.Design: Retrospective, non-interventional cohort study.Setting: Two cohorts were identified from linked national health registers (cohort 1, 2005-2014) and electronic medical records (cohort 2, 2010-2012; primary/secondary care patients from Uppsala and Västerbotten).Participants: Patients (aged ≥18 years) with primary or secondary diagnoses of HF (≥2 International Classification of Diseases and Related Health Problems, 10th revision classification) during the identification period of January 2005 to March 2015 were included.Outcome measures: HRU across the HF phenotypes was assessed with logistic regression. Costs were estimated based on diagnosis-related group codes and general price lists.Results: Total annual costs of secondary care of prevalent HF increased from SEK 6.23 (€0.60) to 8.86 (€0.85) billion between 2005 and 2014. Of 4648 incident patients, HF phenotype was known for 1715: reduced ejection fraction (HFrEF): 64.5%, preserved ejection fraction (HFpEF): 35.5%. Within 1 year of HF diagnosis, the proportion of patients hospitalised was only marginally higher for HFrEF versus HFpEF (all-cause (95% CI): 64.7% (60.8 to 68.4) vs 63.7% (60.8 to 66.5), HR 0.91, p=0.14; cardiovascular disease related (95% CI): 61.1% (57.1 to 64.8) vs 60.9% (58.0 to 63.7), HR 0.93, p=0.28). Frequency of hospitalisations and outpatient visits per patient declined after the first year. All-cause secondary care costs in the first year were SEK 122 758 (€12 890)/patient/year, with HF-specific care accounting for 69% of the costs. Overall, 10% of the most expensive population (younger; predominantly male; more likely to have comorbidities) incurred ~40% of total secondary care costs.Conclusions: HF-associated costs and HRU are high, especially during the first year of diagnosis. This is driven by high hospitalisations rates. Understanding the profile of resource-intensive patients being at younger age, male sex and high Charlson comorbidity index scores at the time of the HF diagnosis is most likely a sign of more severe disease.
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| 41. |
- Boman, Kurt, et al.
(författare)
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Telemedicine improves the monitoring process in anticoagulant treatment
- 2012
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Ingår i: Journal of Telemedicine and Telecare. - : Royal Society of Medicine Press. - 1357-633X .- 1758-1109. ; 18:6, s. 312-316
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Tidskriftsartikel (refereegranskat)abstract
- We compared the INR (International Normalized Ratio) monitoring process using a telemedicine device with the conventional approach in which blood samples were sent to the hospital for analysis. We conducted a randomized controlled trial. We enrolled 40 patients on chronic warfarin therapy from two primary healthcare centres (PHCs). Half were monitored using the telemedicine device and half were monitored conventionally. Each patient received three INR measurements. The total processing time was measured from blood sampling until warfarin dosing was performed in the anticoagulant clinic. The median total processing time was significantly shorter with telemedicine than usual care (34 vs. 260 min, P andlt; 0.001). This was mainly because sample transport was avoided using the point-of-care device and automatic data transmission. Telemedicine reduced the total processing time for INR monitoring and has the potential to improve the management of patients undergoing anticoagulant treatment at PHCs.
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| 42. |
- Brännäs, Kurt, et al.
(författare)
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Panel data regression for counts
- 1996
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Ingår i: Statistical papers. - 0932-5026 .- 1613-9798. ; 37:3, s. 191-213
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Tidskriftsartikel (refereegranskat)abstract
- A new panel data model for count data is introduced. We suggest alternative estimators, such as pseudo maximum likelihood and generalized method of moments, of structural and nuisance parameters. In addition, different test statistics of independence and overdispersion are obtained. The small sample performance of the estimators and tests are evaluated in Monte Carlo experiments. The model is applied to the number of days absent in Sweden 1981-1991 for a panel of Swedish male workers.
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| 43. |
- Brännäs, Kurt, et al.
(författare)
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Time-series count data regression
- 1994
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Ingår i: Communications in Statistics - Theory and Methods. - : Informa UK Limited. - 0361-0926 .- 1532-415X. ; 23:10, s. 2907-2925
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Tidskriftsartikel (refereegranskat)abstract
- The count data model studied in the paper extends the Poisson model by allowing for overdispersion and serial correlation. Alternative approaches to estimate nuisance parameters, required for the correction of the Poisson maximum likelihood covariance matrix estimator and for a quasi-likelihood estimator, are studied. The estimators are evaluated by finite sample Monte Carlo experimentation. It is found that the Poisson maximum likelihood estimator with corrected covariance matrix estimators provide reliable inferences for longer time series. Overdispersion test statistics are wellbehaved, while conventional portmanteau statistics for white noise have too large sizes. Two empirical illustrations are included.
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| 44. |
- Chasman, Daniel I., et al.
(författare)
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Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
- 2012
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:24, s. 5329-5343
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Tidskriftsartikel (refereegranskat)abstract
- In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in FBXL20 (P 5.6 10(9)) in meta-analysis of all available data, and additional SNPs at the INHBC, LRP2, PLEKHA1, SLC3A2 and SLC7A6 genes meeting multiple-testing corrected significance for replication and overall P-values of 4.5 10(4)2.2 10(7). Neither the novel PLEKHA1 nor FBXL20 associations, both further supported by association with eGFR among African Americans and with transcript abundance, would have been implicated by eGFR candidate gene approaches. LRP2, encoding the megalin receptor, was identified through connection with the previously known eGFR gene DAB2 and extends understanding of the megalin system in kidney function. These findings highlight integration of existing genome-wide association data with independent biological knowledge to uncover novel candidate eGFR associations, including candidates lacking known connections to kidney-specific pathways. The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general.
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| 45. |
- Chhita, S., et al.
(författare)
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Asymptotic domino statistics in the Aztec diamond
- 2015
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Ingår i: The Annals of Applied Probability. - 1050-5164 .- 2168-8737. ; 25:3, s. 1232-1278
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Tidskriftsartikel (refereegranskat)abstract
- We study random domino tilings of the Aztec diamond with different weights for horizontal and vertical dominoes. A domino tiling of an Aztec diamond can also be described by a particle system which is a determinantal process. We give a relation between the correlation kernel for this process and the inverse Kasteleyn matrix of the Aztec diamond. This gives a formula for the inverse Kasteleyn matrix which generalizes a result of Helfgott. As an application, we investigate the asymptotics of the process formed by the southern dominoes close to the frozen boundary. We find that at the northern boundary, the southern domino process converges to a thinned Airy point process. At the southern boundary, the process of holes of the southern domino process converges to a multiple point process that we call the thickened Airy point process. We also study the convergence of the domino process in the unfrozen region to the limiting Gibbs measure.
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| 46. |
- Chhita, Sunil, et al.
(författare)
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Domino statistics of the two-periodic Aztec diamond
- 2016
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Ingår i: Advances in Mathematics. - : Elsevier. - 0001-8708 .- 1090-2082. ; 294, s. 37-149
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Tidskriftsartikel (refereegranskat)abstract
- Random domino tilings of the Aztec diamond shape exhibit interesting features and some of the statistical properties seen in random matrix theory. As a statistical mechanical model it can be thought of as a dimer model or as a certain random surface. We consider the Aztec diamond with a two-periodic weighting which exhibits all three possible phases that occur in these types of models, often referred to as solid, liquid and gas. To analyze this model, we use entries of the inverse Kasteleyn matrix which give the probability of any configuration of dominoes. A formula for these entries, for this particular model, was derived by Chhita and Young (2014). In this paper, we find a major simplification of this formula expressing entries of the inverse Kasteleyn matrix by double contour integrals which makes it possible to investigate their asymptotics. In a part of the Aztec diamond, where the asymptotic analysis is simpler, we use this formula to show that the entries of the inverse Kasteleyn matrix converge to the known entries of the full-plane inverse Kasteleyn matrices for the different phases. We also study the detailed asymptotics of the inverse Kasteleyn matrix at both the ‘liquid–solid’ and ‘liquid–gas’ boundaries, and find the extended Airy kernel in the next order asymptotics. Finally we provide a potential candidate for a combinatorial description of the liquid–gas boundary.
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| 47. |
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| 48. |
- Courteaut, Klara, et al.
(författare)
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From Berry–Esseen to super-exponential
- 2024
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Ingår i: Electronic Journal of Probability. - : Institute of Mathematical Statistics. - 1083-6489. ; 29
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Tidskriftsartikel (refereegranskat)abstract
- For any integer m < n, where m can depend on n, we study the rate of convergence (Formula Presented) to its limiting Gaussian as n → ∞ for orthogonal, unitary and symplectic Haar distributed random matrices U of size n. In the unitary case, we prove that the total variation distance is less than (Formula Presented) times a constant. This result interpolates between the super-exponential bound obtained for fixed m and the 1/n bound coming from the Berry–Esseen theorem applicable when m ≥ n by a result of Rains. We obtain analogous results for the orthogonal and symplectic groups. In these cases, our total variation upper bound takes the form (Formula Presented) times a constant and the result holds provided n > 2m. For m = 1, we obtain complementary lower bounds and precise asymptotics for the L2-distances as n → ∞, which show how sharp our results are.
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| 49. |
- Courteaut, Klara
(författare)
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Linear statistics of random matrices and log-gases
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is concerned with point processes arising in Random Matrix Theory. It is a compilation thesis: it consists of an introduction and three research papers.In Paper A and Paper B, we study random matrices from the classical compact groups, namely orthogonal, unitary, and symplectic matrices distributed according to Haar measure. We consider the moments of the empirical spectral measure, i.e. the trace of the powers of the matrices. These are known to converge in distribution, as the dimension of the matrices tends to infinity, to independent, normal random variables. We show that the convergence is especially fast as the total variation distances to the limiting Gaussians decay faster than exponentially.Paper A is devoted to the multivariate case for orthogonal and symplectic matrices: we study the total variation between a vector filled with the trace of the powers of the matrix, and one filled with independent normal random variables. We obtain an explicit upper bound on the total variation which depends on the highest power and the dimension of the matrix, and which, as a function of their ratio, decays faster than exponentially.In Paper B we consider a single trace at a time. This allows to study the trace of a higher power, up to the dimension of the matrix in the unitary case. We show a transition from a super-exponential decay, for small powers, to a decay of Berry-Esseen type, for high powers. The argument also gives more precise bounds. We obtain a first lower bound when the power equals one and determine the exact asymptotics of the L2 distance.In Paper C we consider a Coulomb gas on a sufficiently regular Jordan curve in the plane, at a general temperature. This is a generalization of the Circular β-Ensemble. We derive the asymptotics of the partition function from those of the Laplace transform of linear statistics. The asymptotic formula is expressed, among other things, in terms of the Grunsky operator associated with the exterior conformal mapping for the curve.
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| 50. |
- Courteaut, Klara, et al.
(författare)
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Multivariate normal approximation for traces of orthogonal and symplectic matrices
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We show that the distance in total variation between $(\tr U, \frac{1}{\sqrt{2}}\tr U^2, \cdots, \frac{1}{\sqrt{m}}\tr U^m)$ and a real Gaussian vector, where $U$ is a Haar distributed orthogonal or symplectic matrix of size $2n$ or $2n+1$, is bounded by $\Gamma(2\frac{n}{m}+1)^{-\frac{1}{2}}$ times a correction. The correction term is explicit and holds for all $n\geq m^4$, for $m$ sufficiently large. For $n\geq m^3$ we obtain the bound $(\frac{n}{m})^{-c\sqrt{\frac{n}{m}}}$ with an explicit constant $c$. Our method of proof is based on an identity of Toeplitz+Hankel determinants due to Basor and Ehrhardt, see \cite{BE}, which is also used to compute the joint moments of the traces.
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