| 1. |
|
|
| 2. |
- Antoniadou-Plytaria, Kyriaki, 1989, et al.
(författare)
-
Effect of Short-term and High-resolution Load Forecasting Errors on Microgrid Operation Costs
- 2022
-
Ingår i: IEEE PES Innovative Smart Grid Technologies Conference Europe. - 9781665480321 ; 2022-October
-
Konferensbidrag (refereegranskat)abstract
- The aim of this paper is to evaluate the effect of the load forecasting errors to the operation costs of a grid-connected microgrid. To this end, a microgrid energy scheduling optimization model was tested with deterministic and stochastic formulations under two solution approaches i.e., day-ahead and rolling horizon optimization. In total, twelve simulation test cases were designed receiving as input the forecasts provided by one of the three implemented machine learning models: linear regression, artificial neural network with backpropagation, and long short-term memory. Simulation results of the weekly operation of a real residential building (HSB Living Lab) showed no significant differences among the costs of the test cases for a daily mean absolute percentage forecast error of about 12%. These results suggest that operators of similar microgrid systems could use simplifying approaches, such as day-ahead deterministic optimization, and forecasts of similar, non-negligible accuracy without substantially affecting the microgrid's total cost as compared to the ideal case of perfect forecast. Improving the accuracy would mainly reduce the microgrid's peak power cost as shown by its 20.2% increase in comparison to the ideal case.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Eriksson, Lasse M., et al.
(författare)
-
PID Controller Tuning Rules for Varying Time-Delay Systems
- 2007
-
Ingår i: 2007 AMERICAN CONTROL CONFERENCE, VOLS 1-13. ; , s. 619-625
-
Konferensbidrag (refereegranskat)abstract
- This paper considers the design of PID controllers for systems with varying time-delays. Using the concept of jitter margin combined with the AMIGO tuning rule methodology, novel tuning rules that are robust to varying time-delays are derived. In addition, we give an expression for the expected lower bound of the jitter margin as these tuning rules are applied. Extensive numerical evaluations demonstrate that, for wide range of processes, the new tuning rules achieve significant improvements in jitter margin at the expense of only slight decreases in other performance criteria.
|
|
| 6. |
- Eriksson, Lasse M., et al.
(författare)
-
Simple PID tuning rules for varying time-delay systems
- 2007
-
Ingår i: PROCEEDINGS OF THE 46TH IEEE CONFERENCE ON DECISION AND CONTROL, VOLS 1-14. ; , s. 1801-1807
-
Konferensbidrag (refereegranskat)abstract
- This paper discusses tuning of PID controllers for varying time-delay systems. We analyze the properties of the AMIGO tuning rules of Astrom and Hagglund applied to varying time-delay systems and propose improved tuning rules which increase the robustness to delay variations at the expense of a small degradation in nominal performance. We suggest a tuning scheme that uses the simple AMIGO tuning on an extended plant, and define the design concepts for extending the plant. This approach allows treating the maximum time-delay as a design parameter for the tuning rules. The proposed tuning rules are compared via simulations.
|
|
| 7. |
- Folkersen, Lasse, et al.
(författare)
-
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
- 2020
-
Ingår i: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 2:10, s. 1135-1148
-
Tidskriftsartikel (refereegranskat)abstract
- Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
|
|
| 8. |
- Folkersen, Lasse, et al.
(författare)
-
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
- 2017
-
Ingår i: PLOS Genetics. - : PUBLIC LIBRARY SCIENCE. - 1553-7390 .- 1553-7404. ; 13:4
-
Tidskriftsartikel (refereegranskat)abstract
- Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p<5e-8) association signals, 55 of which replicated at P<0.0007 in separate validation studies (n = 2,639 individuals). Using automated text mining, manual curation, and network-based methods incorporating information on expression quantitative trait loci (eQTL), we propose plausible causal mechanisms for 25 trans-acting loci, including a potential post-translational regulation of stem cell factor by matrix metalloproteinase 9 and receptor-ligand pairs such as RANK-RANK ligand. Using public GWA study data, we further evaluate all 79 loci for their causal effect on coronary artery disease, and highlight several potentially causal associations. Overall, a majority of the plasma proteins studied showed evidence of regulation at the genetic level. Our results enable future studies of the causal architecture of human disease, which in turn should aid discovery of new drug targets.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Galván, Ignacio Fdez., et al.
(författare)
-
OpenMolcas : From Source Code to Insight
- 2019
-
Ingår i: Journal of Chemical Theory and Computation. - : American Chemical Society (ACS). - 1549-9618 .- 1549-9626. ; 15:11, s. 5925-5964
-
Tidskriftsartikel (refereegranskat)abstract
- In this Article we describe the OpenMolcas environment and invite the computational chemistry community to collaborate. The open-source project already includes a large number of new developments realized during the transition from the commercial MOLCAS product to the open-source platform. The paper initially describes the technical details of the new software development platform. This is followed by brief presentations of many new methods, implementations, and features of the OpenMolcas program suite. These developments include novel wave function methods such as stochastic complete active space self-consistent field, density matrix renormalization group (DMRG) methods, and hybrid multiconfigurational wave function and density functional theory models. Some of these implementations include an array of additional options and functionalities. The paper proceeds and describes developments related to explorations of potential energy surfaces. Here we present methods for the optimization of conical intersections, the simulation of adiabatic and nonadiabatic molecular dynamics, and interfaces to tools for semiclassical and quantum mechanical nuclear dynamics. Furthermore, the Article describes features unique to simulations of spectroscopic and magnetic phenomena such as the exact semiclassical description of the interaction between light and matter, various X-ray processes, magnetic circular dichroism, and properties. Finally, the paper describes a number of built-in and add-on features to support the OpenMolcas platform with postcalculation analysis and visualization, a multiscale simulation option using frozen-density embedding theory, and new electronic and muonic basis sets.
|
|
| 12. |
- Hakansson, Jonas, et al.
(författare)
-
Body lift, drag and power are relatively higher in large-eared than in small-eared bat species
- 2017
-
Ingår i: Journal of the Royal Society Interface. - : The Royal Society. - 1742-5689 .- 1742-5662. ; 14:135
-
Tidskriftsartikel (refereegranskat)abstract
- Bats navigate the dark using echolocation. Echolocation is enhanced by external ears, but external ears increase the projected frontal area and reduce the streamlining of the animal. External ears are thus expected to compromise flight efficiency, but research suggests that very large ears may mitigate the cost by producing aerodynamic lift. Here we compare quantitative aerodynamic measures of flight efficiency of two bat species, one large-eared (Plecotus auritus) and one small-eared (Glossophaga soricina), flying freely in a wind tunnel. We find that the body drag of both species is higher than previously assumed and that the large-eared species has a higher body drag coefficient, but also produces relatively more ear/body lift than the small-eared species, in line with prior studies on model bats. The measured aerodynamic power of P. auritus was higher than predicted from the aerodynamic model, while the small-eared species aligned with predictions. The relatively higher power of the large-eared species results in lower optimal flight speeds and our findings support the notion of a trade-off between the acoustic benefits of large external ears and aerodynamic performance. The result of this trade-off would be the ecomorphological correlation in bat flight, with large-eared bats generally adopting slow-flight feeding strategies.
|
|
| 13. |
- Jalkanen, Jukka-Pekka, et al.
(författare)
-
Modeling of ships as a source of underwater noise
- 2017
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Shipping as a source of underwater noise is increasing. Underwater noise emission levels are seldom considered as a ship design parameter unless low vessel noise is specifically required, like in the case of warships and research vessels. Noise emissions are not regulated yet, but the awareness of possible impacts of noise on marine life is increasing. This paper describes the implementation of a noise source model for the Ship Traffic Emission Abatement Model (STEAM; Jalkanen et al. 2009; 2012; Johansson et al, 2017). The combination of vessel technical description and activity can be used to generate noise source maps which are based on actual ship traffic data. The generated noise source maps can ve used to describe the energy emitted as noise to the water, which facilitates regular annual updates of the noise emissions from ship traffic in the Baltic Sea area.
|
|
| 14. |
- Jalkanen, Jukka-Pekka, et al.
(författare)
-
Modelling of discharges from Baltic Sea shipping
- 2021
-
Ingår i: Ocean Science. - : Copernicus GmbH. - 1812-0784 .- 1812-0792.
-
Tidskriftsartikel (refereegranskat)abstract
- This paper describes the new developments of the Ship Traffic Emission Assessment Model (STEAM) which enable the modelling of pollutant discharges to water from ships. These include nutrients from black/grey water discharges as well as from food waste. Further, the modelling of contaminants in ballast, black, grey and scrubber water, bilge discharges, and stern tube oil leaks are also described as well as releases of contaminants from antifouling paints.Each of the discharges is regulated by different sections of the IMO MARPOL convention, and emission patterns of different pollution releases vary significantly. The discharge patterns and total amounts for the year 2012 in the Baltic Sea area are reported and open-loop SOx scrubbing effluent was found to be the second-largest pollutant stream by volume. The scrubber discharges have increased significantly in recent years, and their environmental impacts need to be investigated in detail.
|
|
| 15. |
- Jalkanen, Jukka-Pekka, et al.
(författare)
-
Underwater noise emissions from ships during 2014-2020
- 2022
-
Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491 .- 1873-6424. ; 311
-
Tidskriftsartikel (refereegranskat)abstract
- This paper reports trends in the input of underwater noise source energy emission from global shipping, based on bottom-up modeling of individual ships. In terms of energy, we predict the doubling of global shipping noise emissions every 11.5 years, on average, but there are large regional differences. Shipping noise emissions increase rapidly in Arctic areas and the Norwegian Sea. The largest contributors are the containerships, dry bulk and liquid tanker vessels which emit 75% of the underwater shipping noise source energy. The COVID-19 pandemic changed vessel traffic patterns and our modeling indicates a reduction of -6% in global shipping noise source energy in the 63 Hz 1/3 octave band. This reduction was largest in the Greenland Sea, the Coastal Waters of Southeast Alaska and British Columbia as well as the Gulf of California, temporarily disrupting the increasing pre-pandemic noise emission trend. However, in some sea areas, such as the Indian Ocean, Yellow Sea and Eastern China Sea the emitted noise source energy was only slightly reduced. In global scale, COVID-19 pandemic reduced the underwater shipping noise emissions close to 2017 levels, but it is expected that the increasing trend of underwater noise emissions will continue when the global economy recovers.
|
|
| 16. |
- Johansson, Carina, 1959-, et al.
(författare)
-
Botan som besöksmål
- 2021
-
Ingår i: Botan. - Visby : Eddy.se. - 9789188929402
-
Bokkapitel (populärvet., debatt m.m.)
|
|
| 17. |
- Johansson, Christoffer, et al.
(författare)
-
Ear-body lift and a novel thrust generating mechanism revealed by the complex wake of brown long-eared bats (Plecotus auritus)
- 2016
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Large ears enhance perception of echolocation and prey generated sounds in bats. However, external ears likely impair aerodynamic performance of bats compared to birds. But large ears may generate lift on their own, mitigating the negative effects. We studied flying brown long-eared bats, using high resolution, time resolved particle image velocimetry, to determine the aerodynamics of flying with large ears. We show that the ears and body generate lift at medium to cruising speeds (3-5 m/s), but at the cost of an interaction with the wing root vortices, likely reducing inner wing performance. We also propose that the bats use a novel wing pitch mechanism at the end of the upstroke generating thrust at low speeds, which should provide effective pitch and yaw control. In addition, the wing tip vortices show a distinct spiraling pattern. The tip vortex of the previous wingbeat remains into the next wingbeat and rotates together with a newly formed tip vortex. Several smaller vortices, related to changes in circulation around the wing also spiral the tip vortex. Our results thus show a new level of complexity in bat wakes and suggest large eared bats are less aerodynamically limited than previous wake studies have suggested.
|
|
| 18. |
- Johansson, L. Christoffer, et al.
(författare)
-
Flight in Ground Effect Dramatically Reduces Aerodynamic Costs in Bats
- 2018
-
Ingår i: Current Biology. - : Elsevier BV. - 1879-0445 .- 0960-9822. ; 28:21, s. 3502-3507
-
Tidskriftsartikel (refereegranskat)abstract
- Most flying animals, from insects to seabirds [1], perform flights close to ground or water when taking off or landing [2], drinking, and feeding [3-5] or when traveling near water surfaces [1, 6, 7]. When flying close to a surface within approximately one wingspan, the surface acts as an aerodynamic mirror, interrupting the downwash [8, 9], resulting in increased pressure underneath the wing and suppression of wingtip vortex development [10]. This aerodynamic interaction lowers the energy added to the air by the animal, reducing the cost of flying. Modeling suggests that flapping wings in ground effect can affect the expected power savings compared to gliding flight, either positively or negatively, depending on the wing motion [11-13]. Although aerodynamic theory predicts substantial power reductions when animals fly in ground effect [4-6, 9, 11, 12], quantitative measurements of savings are lacking. Here, we show, through wake-based power measurements, that Daubenton's bats utilize 29% less aerodynamic power when flying in compared to out of ground effect, which is twice the predicted savings. Contrary to theoretical predictions [4-6, 9, 11, 12] we find no variation in savings with distance above ground when in ground effect. Given alterations in kinematics with ground proximity, we hypothesize that modulation of wing kinematics raises the achievable benefit from ground effect relative to current model predictions. The savings from ground effect are comparable to formation flight [14, 15] but are not limited to large bird species. Instead, ground effect is experienced by most flying animals and may have facilitated the evolution of powered animal flight.
|
|
| 19. |
- Johansson, Lasse, et al.
(författare)
-
Model for leisure boat activities and emissions – implementation for the Baltic Sea
- 2020
-
Ingår i: Ocean Science. - : Copernicus GmbH. - 1812-0792 .- 1812-0784. ; 16:5, s. 1143-1163
-
Tidskriftsartikel (refereegranskat)abstract
- The activities and emissions from leisure boats in the Baltic Sea have been modeled in a comprehensive approach for the first time, using a new simulation model leisure Boat Emissions and Activities siMulator (BEAM). The model utilizes survey data to characterize the national leisure boat fleets. Leisure boats have been categorized based on their size, use and engine specifications, and for these subcategories emission factors for NOx, PM2.5, CO, non-methane volatile organic compounds (NMVOCs), and releases of copper (Cu) and zinc (Zn) from antifouling paints have been estimated according to literature values. The modeling approach also considers the temporal and spatial distribution of leisure boat activities, which are applied to each simulated leisure boat separately. According to our results the CO and NMVOC emissions from leisure boats, as well as Cu and Zn released from antifouling paints, are significant when compared against the emissions originating from registered commercial shipping in the Baltic Sea. CO emissions equal 70 % of the registered shipping emissions and NMVOC emissions equal 160 % when compared against the modeled results in the Baltic Sea in 2014. Modeled NOx and PM2.5 from the leisure boats are less significant compared to the registered shipping emissions. The emissions from leisure boats are concentrated in the summer months of June, July and August and are released in the vicinity of inhabited coastal areas. Given the large emission estimates for leisure boats, this commonly overlooked source of emissions should be further investigated in greater detail.
|
|
| 20. |
- Klaric, Lucija, et al.
(författare)
-
Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.
- 2021
-
Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory. ; , s. 1-28
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19. Using protein quantitative trait loci (pQTL) data from the SCALLOP consortium, involving meta-analysis of up to 26,494 individuals, and COVID-19 genome-wide association data from the Host Genetics Initiative, we performed MR for 157 COVID-19 severity protein biomarkers. We identified significant MR results for five proteins: FAS, TNFRSF10A, CCL2, EPHB4 and LGALS9. Further evaluation of these candidates using sensitivity analyses and colocalization testing provided strong evidence to implicate the apoptosis-associated cytokine receptor FAS as a causal mediator of severe COVID-19. This effect was specific to severe disease. Using RNA-seq data from 4,778 individuals, we demonstrate that the pQTL at the FAS locus results from genetically influenced alternate splicing causing skipping of exon 6. We show that the risk allele for very severe COVID-19 increases the proportion of transcripts lacking exon 6, and thereby increases soluble FAS. Soluble FAS acts as a decoy receptor for FAS-ligand, inhibiting apoptosis induced through membrane-bound FAS. In summary, we demonstrate a novel genetic mechanism that contributes to risk of severe of COVID-19, highlighting a pathway that may be a promising therapeutic target.
|
|
| 21. |
- Locke, Adam E, et al.
(författare)
-
Genetic studies of body mass index yield new insights for obesity biology.
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
|
|
| 22. |
- Magnusson, Kerstin, et al.
(författare)
-
Risk assessment of bilge water discharges in two Baltic shipping lanes
- 2018
-
Ingår i: Marine Pollution Bulletin. - : Elsevier. - 0025-326X .- 1879-3363. ; 126, s. 575-584
-
Tidskriftsartikel (refereegranskat)abstract
- Environmental concentrations and effects of bilge water contaminants in two Baltic Sea areas were estimatedfrom modelling of discharge rates and analytical data on bilge water from seven ships. Biodegradation of bilgewater oil was accounted for and annual water concentrations were estimated to peak in late spring, whichcoincides with the beginning of a period with extensive biological activities in the sea.Concentrations on bilgewater metals were calculated both as water concentrations and as the annual contribution of metals to sediments.The predicted bilge water concentrations of oil and metal in the marine environment were estimated tobe 4 to 8 orders of magnitude lower than reported toxic concentrations. However, available toxicity data arebased on short term exposure and there is to date limited information on toxic effects of the small but chronicallyelevated contaminant concentrations derived from bilge water discharge and other operational shipping activities.
|
|
| 23. |
- Maljutenko, Ilja, et al.
(författare)
-
Modelling spatial dispersion of contaminants from shipping lanes in the Baltic Sea
- 2021
-
Ingår i: Marine Pollution Bulletin. - : Elsevier BV. - 0025-326X .- 1879-3363. ; 173
-
Tidskriftsartikel (refereegranskat)abstract
- Major sources of pollution from shipping to marine environments are antifouling paint residues and discharges of bilge, black, grey and ballast water and scrubber discharge water. The dispersion of copper, zinc, naphthalene, pyrene, and dibromochloromethane have been studied using the Ship Traffic Emission Assessment Model, the General Estuarine Transport Model, and the Eulerian tracer transport model in the Baltic Sea in 2012. Annual loads of the contaminants ranged from 10-2 tons for pyrene to 100 s of tons for copper. The dispersion of the contaminants is determined by the surface kinetic energy and vertical stratification at the location of the discharge. The elevated concentration of the contaminants at the surface persists for about two-days and the contaminants are dispersed over the spatial scale of 10-60 km. The Danish Sounds, the southwestern Baltic Sea and the Gulf of Finland are under the heaviest pressure of shipborne contaminants in the Baltic Sea.
|
|
| 24. |
- Marcus, Lars, 1962-, et al.
(författare)
-
Ankeborgsvisioner
- 1994
-
Ingår i: MAMA : magasin för modern arkitektur. - 1102-5409. ; :9
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 25. |
- Menon, Heera, et al.
(författare)
-
Improved quality of InSb-on-insulator microstructures by flash annealing into melt
- 2021
-
Ingår i: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 32:16
-
Tidskriftsartikel (refereegranskat)abstract
- Monolithic integration of III-V semiconductors with Silicon technology has instigated a wide range of new possibilities in the semiconductor industry, such as combination of digital circuits with optical sensing and high-frequency communication. A promising CMOS compatible integration process is rapid melt growth (RMG) that can yield high quality single crystalline material at low cost. This paper represents the study on ultra-thin InSb-on-insulator microstructures integrated on a Si platform by a RMG-like process. We utilize flash lamp annealing (FLA) to melt and recrystallize the InSb material for an ultra-short duration (milliseconds), to reduce the thermal budget necessary for integration with Si technology. We compare the result from FLA to regular rapid thermal annealing (seconds). Recrystallized InSb was characterized using electron back scatter diffraction which indicate a transition from nanocrystalline structure to a crystal structure with grain sizes exceeding 1 μm after the process. We further see a 100× improvement in electrical resistivity by FLA annealed sample when compared to the as-deposited InSb with an average Hall mobility of 3100 cm2 V−1 s−1 making this a promising step towards realizing monolithic mid-infrared detectors and quantum devices based on InSb.
|
|
| 26. |
|
|
| 27. |
- Raudsepp, Urmas, et al.
(författare)
-
Shipborne nutrient dynamics and impact on the eutrophication in the Baltic Sea
- 2019
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 671, s. 189-207
-
Tidskriftsartikel (refereegranskat)abstract
- The Baltic Sea is a severely eutrophicated sea-area where intense shipping as an additional nutrient source is a potential contributor to changes in the ecosystem. The impact of the two most important shipborne nutrients, nitrogen and phosphorus, on the overall nutrient-phytoplankton-oxygen dynamics in the Baltic Sea was determined by using the coupled physical and biogeochemical model system General Estuarine Transport Model–Ecological Regional Ocean Model (GETM-ERGOM) in a cascade with the Ship Traffic Emission Assessment Model (STEAM) and the Community Multiscale Air Quality (CMAQ) model. We compared two nutrient scenarios in the Baltic Sea: with (SHIP) and without nutrient input from ships (NOSHIP). The model uses the combined nutrient input from shipping-related waste streams and atmospheric depositions originating from the ship emission and calculates the effect of excess nutrients on the overall biogeochemical cycle, primary production, detritus formation and nutrient flows. The shipping contribution is about 0.3% of the total phosphorus and 1.25–3.3% of the total nitrogen input to the Baltic Sea, but their impact to the different biogeochemical variables is up to 10%. Excess nitrogen entering the N-limited system of the Baltic Sea slightly alters certain pathways: cyanobacteria growth is compromised due to extra nitrogen available for other functional groups while the biomass of diatoms and especially flagellates increases due to the excess of the limiting nutrient. In terms of the Baltic Sea ecosystem functioning, continuous input of ship-borne nitrogen is compensated by steady decrease of nitrogen fixation and increase of denitrification, which results in stationary level of total nitrogen content in the water. Ship-borne phosphorus input results in a decrease of phosphate content in the water and increase of phosphorus binding to sediments. Oxygen content in the water decreases, but reaches stationary state eventually.
|
|
| 28. |
|
|
| 29. |
- Shungin, Dmitry, et al.
(författare)
-
New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
-
Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
|
|
| 30. |
|
|
| 31. |
- Wilewska-Bien, Magda, 1977, et al.
(författare)
-
Phosphorus flows on ships: Case study from the Baltic Sea
- 2019
-
Ingår i: Proceedings of the Institution of Mechanical Engineers Part M: Journal of Engineering for the Maritime Environment. - : SAGE Publications. - 2041-3084 .- 1475-0902. ; 233:2, s. 528-539
-
Tidskriftsartikel (refereegranskat)abstract
- Material flow analysis is used to identify and quantify the flow of phosphorus (P) in ship-generated food waste and wastewater. Passenger, cruise, RoPax and cargo ships in the Baltic Sea were investigated in three scenarios: (1) if all waste is discharged to sea, (2) if all waste is disposed of ashore or (3) if the food waste fraction is disposed of ashore and wastewater is treated on-board. About 107 tonnes of P is generated annually in the waste streams, with highest contribution of approximately 62 tonnes (58%) from wastewater in the ship-category RoPax. Approximately 24 tonnes of P is contained in the food waste generated by the ships in the study. Forthcoming regulations over allowed nutrient concentrations in sewage will lead to 80% reduction in P from passenger ships and can reduce about 31 tonnes of P entering the Baltic Sea environment. If both sewage and grey water instead are offloaded in port reception facilities, about 76 tonnes of P-reduction to the sea can be reached. As most phosphorus recovery practices currently only are available on land it is recommended to direct the waste streams to port reception facilities for further treatment ashore.
|
|
| 32. |
- Yang, Zhijian, et al.
(författare)
-
Genetic Landscape of the ACE2 Coronavirus Receptor
- 2022
-
Ingår i: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 30:SUPPL 1, s. 36-36
-
Tidskriftsartikel (refereegranskat)abstract
- Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory roles in the cardiovascular and other biological systems. However, the genetic basis of the ACE2 protein levels is not well understood.Methods: We have conducted the largest genome-wide association meta-analysis of plasma ACE2 levels in >28 000 individuals of the SCALLOP Consortium (Systematic and Combined Analysis of Olink Proteins). We summarize the cross-sectional epidemiological correlates of circulating ACE2. Using the summary statistics-based high-definition likelihood method, we estimate relevant genetic correlations with cardiometabolic phenotypes, COVID-19, and other human complex traits and diseases. We perform causal inference of soluble ACE2 on vascular disease outcomes and COVID-19 severity using mendelian randomization. We also perform in silico functional analysis by integrating with other types of omics data.Results: We identified 10 loci, including 8 novel, capturing 30% of the heritability of the protein. We detected that plasma ACE2 was genetically correlated with vascular diseases, severe COVID-19, and a wide range of human complex diseases and medications. An X-chromosome cis-protein quantitative trait loci-based mendelian randomization analysis suggested a causal effect of elevated ACE2 levels on COVID-19 severity (odds ratio, 1.63 [95% CI, 1.10-2.42]; P=0.01), hospitalization (odds ratio, 1.52 [95% CI, 1.05-2.21]; P=0.03), and infection (odds ratio, 1.60 [95% CI, 1.08-2.37]; P=0.02). Tissue- and cell type-specific transcriptomic and epigenomic analysis revealed that the ACE2 regulatory variants were enriched for DNA methylation sites in blood immune cells.Conclusions: Human plasma ACE2 shares a genetic basis with cardiovascular disease, COVID-19, and other related diseases. The genetic architecture of the ACE2 protein is mapped, providing a useful resource for further biological and clinical studies on this coronavirus receptor.
|
|
