| 1. |
- Brodin, Petter, et al.
(författare)
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Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice
- 2010
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 5:10, s. e13174-
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Tidskriftsartikel (refereegranskat)abstract
- Background: A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack, but may at the same time develop NK cell sensitivity, due to failure to express inhibitory ligands for Ly49 receptors. The extent of MHC class I downregulation needed on normal cells to trigger NK cell effector functions is not known. Methodology/Principal Findings: In this study, we show that cells expressing MHC class I to levels well below half of the host level are tolerated in an in vivo assay in mice. Hemizygous expression (expression from only one allele) of MHC class I was sufficient to induce Ly49 receptor downmodulation on NK cells to a similar degree as homozygous expression, despite a strongly reduced cell surface level of MHC class I. Co-expression of weaker MHC class I ligands in the host did not have any further effect on the degree of Ly49 downmodulation. Furthermore, a single MHC class I allele could downmodulate up to three Ly49 receptors on individual NK cells. Only when NK cells simultaneously expressed several Ly49 receptors and hemizygous MHC class I levels, a putative threshold for Ly49 downmodulation was reached. Conclusion: Collectively, our findings suggest that in interactions between NK cells and normal untransformed cells, MHC class I molecules are in most cases expressed in excess compared to what is functionally needed to ensure self tolerance and to induce maximal Ly49 downmodulation. We speculate that the reason for this is to maintain a safety margin for otherwise normal, autologous cells over a range of MHC class I expression levels, in order to ensure robustness in NK cell tolerance.
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| 2. |
- Abrahamsen, Rune, et al.
(författare)
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Dynamic Response of Tall Timber Buildings Under Service Load : The DynaTTB Research Program
- 2020
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Ingår i: EURODYN 2020, XI international conferece on structural dynamics. - : National Technical University of Athens. - 9786188507210 ; , s. 4900-4910
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Konferensbidrag (refereegranskat)abstract
- Wind-induced dynamic excitation is becoming a governing design action determin-ing size and shape of modern Tall Timber Buildings (TTBs). The wind actions generate dynamic loading, causing discomfort or annoyance for occupants due to the perceived horizontal sway – i.e. vibration serviceability failure. Although some TTBs have been instrumented and meas-ured to estimate their key dynamic properties (natural frequencies and damping), no systematic evaluation of dynamic performance pertinent to wind loading has been performed for the new and evolving construction technology used in TTBs. The DynaTTB project, funded by the Forest Value research program, mixes on site measurements on existing buildings excited by heavy shakers, for identification of the structural system, with laboratory identification of building elements mechanical features coupled with numerical modelling of timber structures. The goal is to identify and quantify the causes of vibration energy dissipation in modern TTBs and pro-vide key elements to FE modelers.The first building, from a list of 8, was modelled and tested at full scale in December 2019. Some results are presented in this paper. Four other buildings will be modelled and tested in spring 2020.
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| 3. |
- Abrahamsen, Rune, et al.
(författare)
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Dynamic response of tall timber buildings under service load : results from the dynattb research program
- 2023
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Ingår i: World Conference on Timber Engineering 2023 (WCTE 2023). - : Curran Associates, Inc.. - 9781713873297 ; , s. 2907-2914
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Konferensbidrag (refereegranskat)abstract
- Wind-induced dynamic excitation is a governing design action determining size and shape of modern Tall Timber Buildings (TTBs). The wind actions generate dynamic loading, causing discomfort or annoyance for occupants due to the perceived horizontal sway, i.e. vibration serviceability problem. Although some TTBs have been instrumented and measured to estimate their key dynamic properties (eigenfrequencies, mode shapes and damping), no systematic evaluation of dynamic performance pertinent to wind loading had been performed for the new and evolving construction technologies used in TTBs. The DynaTTB project, funded by the ForestValue research program, mixed on site measurements on existing buildings excited by mass inertia shakers (forced vibration) and/or the wind loads (ambient vibration), for identification of the structural system, with laboratory identification of building elements mechanical features, coupled with numerical modelling of timber structures. The goal is to identify and quantify the causes of vibration energy dissipation in modern TTBs and provide key elements to finite element models. This paper presents an overview of the results of the project and the proposed Guidelines for design of TTBs in relation to their dynamic properties.
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| 4. |
- Bengtsson, Johan, et al.
(författare)
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Closed-loop Combustion Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2004
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Ingår i: International Journal of Adaptive Control and Signal Processing. - : Wiley. - 0890-6327 .- 1099-1115. ; 18:2, s. 167-179
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Tidskriftsartikel (refereegranskat)abstract
- Homogeneous charge compression ignition (HCCI) is a hybrid of the sparkignition and compression ignition engine concepts. As in a sparkignition engine, a homogeneous fuel-air mixture is created in theinlet system. During the compression stroke the temperature of themixture increases and reaches the point of auto ignition, just as in acompression ignition engine (or Diesel). One challenge with HCCI engines isthe need for good timing control of the combustion. Auto ignition of ahomogeneous mixture is very sensitive to operating condition. Evensmall variations of the load can change the timing from too early totoo late combustion. Thus a fast combustion timing control isnecessary since it sets the performance limitation of the loadcontrol. As measurement for combustion timing feedback, the crank angleof 50% burnt has been used. This paper performs a comparative studyof different cylinder-pressure based methods for estimating the crankangle of 50% burnt. The estimates are compared in terms of accuracy,robustness and feasibility for cycle-to-cycle real-time control.Dynamic models of CA50 are estimated using system identification asa means to find models relevant to engine control.
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| 5. |
- Bengtsson, Johan, et al.
(författare)
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Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2004
-
Ingår i: Proceedings of the 2004 American Control Conference, ACC : June 30 - July 2, 2004, Boston Sheraton Hotel, Boston, Massachusetts. - 0743-1619. - 0780383354 ; 5, s. 4048-4053
-
Konferensbidrag (refereegranskat)abstract
- The Homogeneous Charge Compression Ignition (HCCI) combustionconcept lacks direct ignition timing control, instead the autoignition depends on the operating condition. Since auto ignition of ahomogeneous mixture is very sensitive to operating conditions, a fastcombustion timing control is necessary for reliable operation. Hence,feedback is needed and the crank angle of 50% burnt (CA50) has provedto be a reliable feedback indicator of on-going combustion inpractice. CA50 or other methods for detecting on-going cylinderpressure used in the feedback control of a HCCI engine all rely onpressure sensors. This paper presents a newcandidate for control of HCCI engine by using the electronicconductive properties in the reaction zone. This phenomenon is calledion current. This paper perform combustion timing control based on ioncurrent and compare it with control based on pressure sensor. Thecombustion timing control is performed on cycle-to-cycle basis and the engine is a one-cylinder version of a heavy duty engine equipped with a port injection system using dual fuels.
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| 6. |
- Bengtsson, Johan, et al.
(författare)
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Hybrid Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2006
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Ingår i: International Journal of Control. - : Informa UK Limited. - 0020-7179 .- 1366-5820. ; 79:5, s. 422-448
-
Tidskriftsartikel (refereegranskat)abstract
- The homogeneous charge compression ignition ( HCCI) combustion engine principle lacks direct ignition timing control, instead the auto-ignition depends on the operating condition. Since auto-ignition of a homogeneous mixture is very sensitive to operating conditions, fast combustion phasing control is necessary for reliable operation. For this paper, a six-cylinder heavy-duty HCCI engine was controlled on a cycle-to-cycle basis in real time. Sensors, actuators and control structures for control of the HCCI combustion were compared. Among several actuators for HCCI engine control suggested, two actuators were compared-i.e., dual-fuel actuation and variable valve actuation (VVA). As for control principles, model predictive control (MPC) has several desirable features and today MPC can be applied to relatively fast systems, such as VVA and dual-fuel actuation. For sensor feedback control of the HCCI engine, cylinder pressure and ion current - i.e., the electronic conductive properties in the reaction zone - were compared. Combustion phasing control based on ion current was compared to control based on cylinder pressure. For the purpose of control synthesis requiring dynamic models, system identification provided models of the HCCI combustion, the models being validated by stochastic model validation. With such models providing a basis for model-based control, MPC control results were compared to PID and LQG control results. While satisfying the constraints on cylinder pressure, both control of the combustion phasing and control of load torque was achieved with simultaneous minimization of the fuel consumption and emissions.
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| 7. |
- Bengtsson, Johan, et al.
(författare)
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Model Predictive Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2006
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Ingår i: 2006 IEEE Conference on Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control. ; , s. 1675-1680
-
Konferensbidrag (refereegranskat)abstract
- The Homogeneous Charge Compression Ignition ({HCCI}) combustion principle lacks direct ignition timing control, instead the auto-ignition depends on the operating condition and fast combustion phasing control is necessary for reliable operation. A six-cylinder heavy-duty HCCI engine was controlled on a cycle-to-cycle basis in real time using a variety of sensors, actuators and control structures for control of the {HCCI} combustion in comparison. Combustion phasing control based on ion current was compared to feedback control based on cylinder pressure. Two actuators were compared, dual fuel and Variable Valve Actuation (VVA). Model-based control synthesis requiring dynamic models of low complexity and HCCI combustion models were estimated by system identification and by physical modeling. The models identified by system identification were used to design model-predictive control (MPC) with several desirable features and today applicable to relatively fast systems. Both control of the combustion phasing and control of load-torque with simultaneous minimization of the fuel consumption and emissions were included.
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| 8. |
- Bengtsson, Johan, et al.
(författare)
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Multi-Output Control of a Heavy Duty HCCI Engine Using Variable Valve Actuation and Model Predictive Control
- 2006
-
Ingår i: 2006 SAE World Congress. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International.
-
Konferensbidrag (refereegranskat)abstract
- Autoignition of a homogeneous mixture is very sensitive to operating conditions, therefore fast control is necessary for reliable operation. There exists several means to control the combustion phasing of an Homogeneous Charge Compression Ignition (HCCI) engine, but most of the presented controlled HCCI result has been performed with single-input single-output controllers. In order to fully operate an HCCI engine several output variables need to be controlled simultaneously, for example, load, combustion phasing, cylinder pressure and emissions. As these output variables have an effect on each other, the controller should be of a structure which includes the cross-couplings between the output variables. A Model Predictive Control (MPC) controller is proposed as a solution to the problem of load-torque control with simultaneous minimization of the fuel consumption and emissions, while satisfying the constraints on cylinder pressure. One of the major motivations for using MPC is that it explicitly takes the constraints into account. When operating an HCCI engine there are several contraints present, for example on the cylinder pressure and on the emissions. A drawback of MPC is the potentially large on-line computational effort, which has historically limited its application to relative slow and/or small applications. Today, MPC can be applied in relative fast systems, and we will demonstrate that it can be used for control of HCCI engine dynamics on a cycle-to-cycle basis. As feedback signal of the combustion phasing, the crank angle for 50% burned, based on cylinder pressure, is used. In the control design of the MPC controllers (one for each cylinder), dynamic models obtained by system identification were used. This paper presents cycle-to-cycle cylinder individual control results from a six-cylinder HCCI engine using a Variable Valve Actuation (VVA) system and MPC controllers.
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| 9. |
- Bengtsson, Johan, et al.
(författare)
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System Identification of Homogenous Charge Compression Ignition (HCCI) Engine Dynamics
- 2004
-
Ingår i: Advances in Automotive Control. - 0080442501 ; 37:22, s. 37-37
-
Konferensbidrag (refereegranskat)abstract
- Homogeneous Charge Compression Ignition (HCCI) combustion lacksdirect ignition timing control, instead the auto ignition depends on the operatingcondition. Since auto ignition of a homogeneous mixture is very sensitive tooperating condition a fast combustion timing control is necessary for reliableoperation, the ignition timing control design requiring appropriate modelsand system output variables for its feedback design. This paper demonstratesthe use of system modeling and identification as a means to find modelsrelevant to the engine control. The identification methods used were varioussubspace-based methods. An LQG controller was designed based on the estimatedmodels and tested on a six-cylinder heavy duty engine running in HCCI operation.
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| 10. |
- Ekholm, Kent, et al.
(författare)
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Ethanol-Diesel Fumigation in a Multi-Cylinder Engine
- 2008
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Ingår i: SAE technical paper 2008-01-0033.
-
Konferensbidrag (refereegranskat)abstract
- Fumigation was studied in a 12 L six-cylinder heavy-duty engine. Port-injected ethanol was ignited with a small amount of diesel injected into the cylinder. The setup left much freedom for influencing the combustion process, and the aim of this study was to find operation modes that result in a combustion resembling that of a homogeneous charge compression ignition (HCCI) engine with high efficiency and low NOx emissions. Igniting the ethanol-air mixture using direct-injected diesel has attractive properties compared to traditional HCCI operation where the ethanol is ignited by pressure alone. No preheating of the mixture is required, and the amount of diesel injected can be used to control the heat release rate. The two fuel injection systems provide a larger flexibility in extending the HCCI operating range to low and high loads. It was shown that cylinder-to-cylinder variations present a considerable challenge for this type of combustion. By using closed-loop cylinder-individual control based on incylinder pressure sensors, combustion was successfully harmonized between the cylinders. Successful fumigation operation was verified up to 18.4 bar BMEP at a fixed engine speed of 1450 rpm. Two load points (4.6 bar BMEP and 9.2 bar BMEP) were studied in detail. Different diesel injection timings, diesel ratios, and EGR rates were investigated, and comparisons were drawn to pure diesel operation of the same engine. At medium load (9.2 bar BMEP), it was possible to obtain a stable HCCI-like combustion with low NOx emissions (0.1 g/kWh), reasonably high brake efficiency (37 %), and low pressure derivatives (5 bar/CAD). High load operation (18.4 bar BMEP) resulted in low pressure derivatives (5.5 bar/CAD), acceptable brake efficency (36 %), and relatively low NOx emissions (0.34 g/kWh).
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| 11. |
- Ekholm, Kent, et al.
(författare)
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Ethanol-Diesel Fumigation in a Multi-Cylinder Engine
- 2009
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Ingår i: SAE International Journal of Fuels and Lubricants. - 1946-3952. ; 1:1, s. 26-36
-
Tidskriftsartikel (refereegranskat)abstract
- Fumigation was studied in a 12 L six-cylinder heavy-duty engine. Port-injected ethanol was ignited with a small amount of diesel injected into the cylinder. The setup left much freedom for influencing the combustion process, and the aim of this study was to find operation modes that result in a combustion resembling that of a homogeneous charge compression ignition (HCCI) engine with high efficiency and low NOx emissions. Igniting the ethanol-air mixture using direct-injected diesel has attractive properties compared to traditional HCCI operation where the ethanol is ignited by pressure alone. No preheating of the mixture is required, and the amount of diesel injected can be used to control the heat release rate. The two fuel injection systems provide a larger flexibility in extending the HCCI operating range to low and high loads. It was shown that cylinder-to-cylinder variations present a challenge for this type of combustion. By using closed-loop cylinder-individual control of pressure derivatives and IMEP with the amounts of fuels injected, combustion was successfully harmonized between the cylinders. Successful fumigation operation was verified up to 18.4 bar BMEP at a fixed engine speed of 1450 rpm. Two load points (4.6 bar BMEP and 9.2 bar BMEP) were studied in detail. Different diesel injection timings, diesel ratios, and EGR rates were investigated, and comparisons were drawn to pure diesel operation of the same engine. At medium load (9.2 bar BMEP), it was possible to obtain a stable HCCI-like combustion with low NOx emissions (0.1 g/kWh), reasonably high brake efficiency (38 %), and low pressure derivatives (5 bar/CAD). High load operation (18.4 bar BMEP) resulted in low pressure derivatives (5.5 bar/CAD), acceptable brake efficency (38 %), and relatively low NOx emissions (0.34 g/kWh).
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| 12. |
- Fornara, Andrea, et al.
(författare)
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Tailored Magnetic Nanoparticles for Direct and Sensitive Detection of Biomolecules in Biological Samples
- 2008
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Ingår i: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 8:10, s. 3423-3428
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Tidskriftsartikel (refereegranskat)abstract
- We developed nanoparticles with tailored magnetic properties for sensitive detection of biomolecules directly in biological samples in a single step. Thermally blocked nanoparticles obtained by thermal hydrolysis are mixed with sample solutions and the variation of the magnetic relaxation due to surface binding is used to detect the presence of biomolecules. The binding events significantly increase the hydrodynamic volume of nanoparticles, thus changing their Brownian relaxation frequency which is measured by a specifically developed AC-susceptometer.The system was tested for the presence of Brucella antibodies in serum samples from infected cows and the surface of the nanoparticles was functionalized with lipopolysaccarides (LPS) from Brucella abortus. The hydrodynamic volume of functionalized particles increased by 25-35% as a result of the binding of the antibodies, as measured by changes in the susceptibility in an alternating magnetic field. The method has shown high sensitivity, with detection limit of 7 nmol·L-1 in serum without any pre-treatment of the biological samples.The detection method is very sensitive, cost-efficient and versatile, giving a direct indication if the animal is infected or not, making it suitable for point-of care applications. The functionalization of tailored magnetic nanoparticles can be modified to suit numerous homogenous assays for a wide range of applications.
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| 13. |
- Henningsson, Maria, et al.
(författare)
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Closed-Loop Control of Combustion Phasing in an HCCI Engine Using VVA and Variable EGR
- 2007. - 10
-
Ingår i: 5th IFAC Symposium on Advances in Automotive Control. ; 40, s. 501-506
-
Konferensbidrag (refereegranskat)abstract
- A homogeneous charge compression ignition (HCCI) engine requires closed-loop control of combustion phasing for reliable operation. Variable valve actuation (VVA) has previously been shown to enable cycle-to-cycle, cylinder-individual control with high precision, but suffers from a narrow operating range. Adding variable exhaust gas recirculation (EGR) to the closed-loop control structure can extend the operating range. A mid-ranging control structure is presented here for combined VVA and EGR actuations in a multi-cylinder engine. The control structure is simple to implement and preserves the fast, cylinder-individual, and precise actuation of the VVA system while extending the operating range. Experimental results verify the performance of the control structure.
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| 14. |
- Johansson, Lars-Olof, 1957, et al.
(författare)
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Goal conflicts in political decision making: a survey of municipality politicians' view of road pricing.
- 2004
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Ingår i: Environment & Planning C: Government & Policy. - 0263-774X. ; 21:4, s. 615-624
-
Tidskriftsartikel (refereegranskat)abstract
- Investigates the existence of goal conflicts in political decision-making in the case of municipality politicians in Sweden on the issue of road pricing scheme. Goals of municipality politicians other than reducing car use; Possibility of failure in achieving environmental goals because of goal conflicts.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Simonson, Oscar E., et al.
(författare)
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In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
- 2015
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Ingår i: Stem Cells Translational Medicine. - : Oxford University Press (OUP). - 2157-6564 .- 2157-6580. ; 4:10, s. 1199-1213
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Tidskriftsartikel (refereegranskat)abstract
- Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 x 10(6) cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1199-1213
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| 19. |
- Strandh, Petter, et al.
(författare)
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Cycle-to-Cycle Control of a Dual-Fuel HCCI Engine
- 2004
-
Ingår i: SAE Paper 2004-01-0941. - 0148-7191. - 0768013550 ; SP-1819
-
Konferensbidrag (refereegranskat)abstract
- A known problem of the HCCI engine is its lack of direct control andits requirements of feedback control. Today there exists severaldifferent means to control an HCCI engine, such as dual fuels,variable valve actuation, inlet temperature and compression ratio.Independent of actuation method a sensor is needed. In this paper weperform closed-loop control based on two different sensors, pressureand ion current sensor. Results showing that they give similar controlperformance within their operating range are presented.Also a comparison of two methods of designing HCCI timing controller,manual tuning and model based design is presented. A PIDcontroller is used as an example of a manually tuned controller. ALinear Quadratic Gaussian controller exemplifies model basedcontroller design. The models used in the design were estimated usingsystem identification methods.The system used in this paper performs control on cycle-to-cyclebasis. This leads to fast and robust control. Dual fuels withdifferent octane numbers were used to control the combustion timing.The engine was a 12 liter 6 cylinder heavy-duty diesel engine modifiedwith a port fuel injection system which has dual fuels connected.
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| 20. |
- Strandh, Petter, et al.
(författare)
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Ion Current Sensing for HCCI Combustion Feedback
- 2003
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Ingår i: SAE Technical Papers. - 0148-7191. ; :2003-01-3216
-
Konferensbidrag (refereegranskat)abstract
- Measurement of ion current signal from HCCI combustionwas performed. The aim of the work was to investigateif a measurable ion current signal exists and if it is possible to obtain useful information about the combustion process. Furthermore, influence of mixture quality in termsof air/fuel ratio and EGR on the ion current signal wasstudied. A conventional spark plug was used as ionizationsensor. A DC voltage (85 Volt) was applied acrossthe electrode gap. By measuring the current through thegap the state of the gas can be probed. A comparisonbetween measured pressure and ion current signal wasperformed, and dynamic models were estimated by usingsystem identification methods.The study shows that an ion current signal can be obtainedfrom HCCI combustion and that the signal levelis very sensitive to the fuel/air equivalence ratio. Themost important result from this study is that the ion current signal proved to be an excellent indicator of the actual combustion timing which is crucial piece of information for HCCI control.
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| 21. |
- Strandh, Petter, et al.
(författare)
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Variable Valve Actuation for Timing Control of a Homogeneous Charge Compression Ignition Engine
- 2005
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Ingår i: SAE Technical Papers 2005-01-0147. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
-
Konferensbidrag (refereegranskat)abstract
- Autoignition of a homogeneous mixture is very sensitiveto operating conditions. Therefore fast combustion phasingcontrol is necessary for reliable operation. There areseveral means to control the combustion phasing of a Homogeneous Charge Compression Ignition (HCCI) engine.This paper presents cycle-to-cycle cylinder individual controlresults from a six-cylinder HCCI engine using a VariableValve Actuation (VVA) system. As feedback signal,the crank angle for 50% burned, based on cylinder pressure,is used. Three control structures are evaluated,Model Predictive Control (MPC), Linear Quadratic Gaussiancontrol (LQG) and PID control. In the control designof the MPC and LQG controller, dynamic models obtainedby system identication were used. Successful experimentswere performed on a port-injected six-cylinderheavy-duty Diesel engine operating in HCCI mode.
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| 22. |
- Aardema, Frederick, et al.
(författare)
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Choice Blindness, Confabulatory Introspection, and Obsessive-Compulsive Symptoms: A New Area of Investigation
- 2014
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Ingår i: International Journal of Cognitive Therapy. - : Springer Science and Business Media LLC. - 1937-1209 .- 1937-1217. ; 7:1, s. 83-102
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Tidskriftsartikel (refereegranskat)abstract
- The current study is the first to investigate confabulatory introspection in relation to clinical psychological symptoms utilizing the Choice Blindness Paradigm (CBP). It was hypothesized that those with obsessive-compulsive symptoms are more likely to confabulate mental states. To test this hypothesis, an experimental choice blindness task was administered in two nonclinical samples (n = 47; n = 76). Results showed that a confabulatory introspection is significantly related to obsessive-compulsive symptoms. There was evidence for its specificity to symptoms of OCD depending on the obsessional theme addressed in the choice blindness task. However, confabulatory introspection was also found to be relevant to other symptoms, including depression and schizotypy. The results highlight a potentially fruitful new area of clinical investigation in the area of insight and self-knowledge, not limited to OCD alone, but potentially other disorders as well.
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| 23. |
- Abrahamsson, Maria, et al.
(författare)
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A 3.0 mu s room temperature excited state lifetime of a bistridentate Ru-II-polypyridine complex for rod-like molecular arrays
- 2006
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 128:39, s. 12616-12617
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Tidskriftsartikel (refereegranskat)abstract
- A bistridentate RuII-polypyridine complex [Ru(bqp)2]2+ (bqp = 2,6-bis(8'-quinolinyl)pyridine) has been prepared, which has a coordination geometry much closer to a perfect octahedron than the typical Ru(terpyridine)2-type complex. Thus, the complex displays a 3.0 mus lifetime of the lowest excited metal-to-ligand charge transfer (3MLCT) state at room temperature. This is, to the best of our knowledge, the longest MLCT state lifetime reported for a RuII-polypyridyl complex at room temperature. The structure allows for the future construction of rod-like, isomer-free molecular arrays by substitution of donor and acceptor moieties on the central pyridine units. This makes it a promising photosensitizer for applications in molecular devices for artificial photosynthesis and molecular electronics.
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| 24. |
- Abrahamsson, Maria, et al.
(författare)
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Bistridentate Ruthenium(II)polypyridyl-Type Complexes with Microsecond 3MLCT State Lifetimes : Sensitizers for Rod-Like Molecular Arrays
- 2008
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Ingår i: Journal of the American Chemical Society. - : ACS. - 0002-7863 .- 1520-5126. ; 130:46, s. 15533-15542
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Tidskriftsartikel (refereegranskat)abstract
- A series of bistridentate ruthenium(II) polypyridyl-type complexes based on the novel 2,6-di(quinolin-8-yl)pyridine (dqp) ligand have been synthesized and their photophysical properties have been studied. The complexes are amenable to substitution in the 4-position of the central pyridine with conserved quasi-C2v symmetry, which allows for extension to isomer-free, rod-like molecular arrays for vectorial control of electron and energy transfer. DFT calculations performed on the parent [Ru(dqp) 2](2+) complex (1) predicted a more octahedral structure than in the typical bistridentate complex [Ru(tpy)2](2+) (tpy is 2,2':6',2"-terpyridine) thanks to the larger ligand bite angle, which was confirmed by X-ray crystallography. A strong visible absorption band, with a maximum at 491 nm was assigned to a metal-to-ligand charge transfer (MLCT) transition, based on time-dependent DFT calculations. 1 shows room temperature emission (Phi = 0.02) from its lowest excited ((3)MLCT) state that has a very long lifetime (tau = 3 micros). The long lifetime is due to a stronger ligand field, because of the more octahedral structure, which makes the often dominant activated decay via short-lived metal-centered states insignificant also at elevated temperatures. A series of complexes based on dqp with electron donating and/or accepting substituents in the 4-position of the pyridine was prepared and the properties were compared to those of 1. An unprecedented (3)MLCT state lifetime of 5.5 micros was demonstrated for the homoleptic complex based on dqpCO2Et. The favorable photosensitizer properties of 1, such as a high extinction coefficient, high excited-state energy and long lifetime, and tunable redox potentials, are maintained upon substitution. In addition, the parent complex 1 is shown to be remarkably photostable and displays a high reactivity in light-induced electron and energy transfer reactions with typical energy and electron acceptors and donors: methylviologen, tetrathiofulvalene, and 9,10-diphenylanthracene. This new class of complexes constitutes a promising starting point for the construction of linear, rod-like molecular arrays for photosensitized reactions and applications in artificial photosynthesis and molecular electronics.
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| 25. |
- Abrahamsson, Maria, et al.
(författare)
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Bistridentate Ruthenium(II)polypyridyl-Type Complexes with Microsecond (MLCT)-M-3 State Lifetimes: Sensitizers for Rod-Like Molecular Arrays
- 2008
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 130:46, s. 15533-15542
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Tidskriftsartikel (refereegranskat)abstract
- A series of bistridentate ruthenium(II) polypyridyl-type complexes based on the novel 2,6-di(quinolin-8-yl)pyridine (dqp) ligand have been synthesized and their photophysical properties have been studied. The complexes are amenable to substitution in the 4-position of the central pyridine with conserved quasi-C-2v symmetry, which allows for extension to isomer-free, rod-like molecular arrays for vectorial control of electron and energy transfer. DIFT calculations performed on the parent [Ru(dqp)(2)](2+) complex (1) predicted a more octahedral structure than in the typical bistridentate complex [Ru(tpy)(2)](2+) (tpy is 2,2':6',2 ''-terpyridine) thanks to the larger ligand bite angle, which was confirmed by X-ray crystallography. A strong visible absorption band, with a maximum at 491 nm was assigned to a metal-to-ligand charge transfer (MLCT) transition, based on time-dependent DIFT calculations. 1 shows room temperature emission (Phi = 0.02) from its lowest excited ((MLCT)-M-3) state that has a very long lifetime (tau = 3 mu s). The long lifetime is due to a stronger ligand field, because of the more octahedral structure, which makes the often dominant activated decay via short-lived metal-centered states insignificant also at elevated temperatures. A series of complexes based on dqp with electron donating and/or accepting substituents in the 4-position of the pyridine was prepared and the properties were compared to those of 1. An unprecedented (MLCT)-M-3 state lifetime of 5.5 mu s was demonstrated for the homoleptic complex based on dqpCO(2)Et. The favorable photosensitizer properties of 1, such as a high extinction coefficient, high excited-state energy and long lifetime, and tunable redox potentials, are maintained upon substitution. In addition, the parent complex 1 is shown to be remarkably photostable and displays a high reactivity in light-induced electron and energy transfer reactions with typical energy and electron acceptors and donors: methylviologen, tetrathiofulvalene, and 9,10-diphenylanthracene. This new class of complexes constitutes a promising starting point for the construction of linear, rod-like molecular arrays for photosensitized reactions and applications in artificial photosynthesis and molecular electronics.
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| 26. |
- Abrahamsson, Maria, et al.
(författare)
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Steric influence on the excited-state lifetimes of ruthenium complexes with bipyridyl-alkanylene-pyridyl ligands.
- 2008
-
Ingår i: Inorganic Chemistry. - : ACS. - 0020-1669 .- 1520-510X. ; 47:9, s. 3540-3548
-
Tidskriftsartikel (refereegranskat)abstract
- The structural effect on the metal-to-ligand charge transfer (MLCT) excited-state lifetime has been investigated in bis-tridentate Ru(II)-polypyridyl complexes based on the terpyridine-like ligands [6-(2,2'-bipyridyl)](2-pyridyl)methane (1) and 2-[6-(2,2'-bipyridyl)]-2-(2-pyridyl)propane (2). A homoleptic ([Ru(2)(2)](2+)) and a heteroleptic complex ([Ru(ttpy)(2)](2+)) based on the new ligand 2 have been prepared and their photophysical and structural properties studied experimentally and theoretically and compared to the results for the previously reported [Ru(1)(2)](2+). The excited-state lifetime of the homoleptic Ru-II complex with the isopropylene-bridged ligand 2 was found to be 50 times shorter than that of the corresponding homoleptic Ru-II complex of ligand 1, containing a methylene bridge. A comparison of the ground-state geometries of the two homoleptic complexes shows that steric interactions involving the isopropylene bridges make the coordination to the central Ru-II ion less octahedral in [Ru(2)(2)](2+) than in [Ru(1)(2))(2+). Calculations indicate that the structural differences in these complexes influence their ligand field splittings as well as the relative stabilities of the triplet metal-to-ligand charge transfer ((MLCT)-M-3) and metal-centered ((MC)-M-3) excited states. The large difference in measured excited-state lifetimes for the two homoleptic Ru-II complexes is attributed to a strong influence of steric interactions on the ligand field strength, which in turn affects the activation barriers for thermal conversion from (MLCT)-M-3 states to short-lived (MC)-M-3 states.
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| 27. |
- Ahlinder, Jon, et al.
(författare)
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Increased knowledge of Francisella genus diversity highlights the benefits of optimised DNA-based assays
- 2012
-
Ingår i: BMC Microbiology. - : Springer Science and Business Media LLC. - 1471-2180. ; 12, s. 220-
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Recent advances in sequencing technologies offer promising tools for generating large numbers of genomes, larger typing databases and improved mapping of environmental bacterial diversity. However, DNA-based methods for the detection of Francisella were developed with limited knowledge about genetic diversity. This, together with the high sequence identity between several Francisella species, means there is a high risk of false identification and detection of the highly virulent pathogen Francisella tularensis. Moreover, phylogenetic reconstructions using single or limited numbers of marker sequences often result in incorrect tree topologies and inferred evolutionary distances. The recent growth in publicly accessible whole-genome sequences now allows evaluation of published genetic markers to determine optimal combinations of markers that minimise both time and laboratory costs. Results: In the present study, we evaluated 38 previously published DNA markers and the corresponding PCR primers against 42 genomes representing the currently known diversity of the genus Francisella. The results highlight that PCR assays for Francisella tularensis are often complicated by low specificity, resulting in a high probability of false positives. A method to select a set of one to seven markers for obtaining optimal phylogenetic resolution or diagnostic accuracy is presented. Conclusions: Current multiple-locus sequence-typing systems and detection assays of Francisella, could be improved by redesigning some of the primers and reselecting typing markers. The use of only a few optimally selected sequence-typing markers allows construction of phylogenetic topologies with almost the same accuracy as topologies based on whole-genome sequences.
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| 28. |
- Almqvist, Sofia, 1980, et al.
(författare)
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Amelogenin is phagocytized and induces changes in integrin configuration, gene expression and proliferation of cultured human dermal fibroblasts
- 2010
-
Ingår i: Journal of Materials Science. Materials in Medicine. - : Springer Science and Business Media LLC. - 1573-4838 .- 0957-4530. ; 21:3, s. 947-954
-
Tidskriftsartikel (refereegranskat)abstract
- Fibroblasts are central in wound healing by expressing important mediators and producing and remodelling extracellular matrix (ECM) components. This study aimed at elucidating possible mechanisms of action of the ECM protein amelogenin on normal human dermal fibroblasts (NHDF). Amelogenin at 100 and 1000 μg/ml increased binding of NHDF via several integrins, including αvβ3, αvβ5 and α5β1. Further, both surface interaction and cellular uptake of amelogenin by NHDF was observed using scanning and transmission electron microscopy. Gene microarray studies showed >8-fold up or down-regulation of genes, of which most are involved in cellular growth, migration and differentiation. The effect of amelogenin was exemplified by increased proliferation over 7 days. In conclusion, the beneficial effects of amelogenin on wound healing are possibly conducted by stimulating fibroblast signalling, proliferation and migration via integrin interactions. It is hypothesized that amelogenin stimulates wound healing by providing connective tissue cells with a temporary extracellular matrix.
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| 29. |
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| 30. |
- Andersson, Henric, 1963-
(författare)
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Aircraft Systems Modeling : Model Based Systems Engineering in Avionics Design and Aircraft Simulation
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aircraft developers like other development and manufacturing companies, are experiencing increasing complexity in their products and growing competition in the global market. One way to confront the challenges is to make the development process more efficient and to shorten time to market for new products/variants by using design and development methods based on models. Model Based Systems Engineering (MBSE) is introduced to, in a structured way, support engineers with aids and rules in order to engineer systems in a new way.In this thesis, model based strategies for aircraft and avionics development are studied. A background to avionics architectures and in particular Integrated Modular Avionics is described. The integrating discipline Systems Engineering, MBSE and applicable standards are also described. A survey on available and emerging modeling techniques and tools, such as Hosted Simulation, is presented and Modeling Domains are defined in order to analyze the engineering environment with all its vital parts to support an MBSE approach.Time and money may be saved by using modeling techniques that enable understanding of the engineering problem, state-of-the-art analysis and team communication, with preserved or increased quality and sense of control. Dynamic simulation is an activity increasingly used in aerospace, for several reasons; to prove the product concept, to validate stated requirements, and to verify the final implementation. Simulation is also used for end-user training, with specialized training simulators, but with the same underlying models. As models grow in complexity, and the set of simulation platforms is expanded, new needs for specification, model building and configuration support arise, which requires a modeling framework to be efficient.
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| 31. |
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| 32. |
- Andersson, Petter, et al.
(författare)
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Roads may act as barriers to flying insects : Species composition of bees and wasps differs on two sides of a large highway
- 2017
-
Ingår i: Nature Conservation. - : Pensoft Publishers. - 1314-6947 .- 1314-3301. ; 18, s. 47-59
-
Tidskriftsartikel (refereegranskat)abstract
- Roads may act as barriers to animal movements, but direct barrier effects on insects have rarely been studied. In this study we collected data on bees and wasps along two sides of a large road in Sweden using yellow pan traps. We then analyzed if the species composition differed between the two sides of the road; first for the whole community, and then only for the smallest species (which typically are poorer dispersers). As a complement, we analyzed if different vegetation variables differed between the two sides of the road, as this may also affect differences in species composition. Finally, we analyzed if species richness and abundance in general differed between the two sides and how these two response variables were explained by the vegetation variables. There was a significant difference in species composition between the eastern and the western side of the road when analyzing the whole community, and this relationship became even stronger when the largest species were excluded. The vegetation variables did not strongly differ between the two sides, and there was no difference in species richness and abundance of bees and wasps either. Abundance was, however, explained by the number of flowering plants in the surroundings of the trap. Even though using a rather limited data set, our results indicate that large roads may act as barriers on the movement of bees and wasps, especially for small species with poor dispersal ability. On the other hand, road verges may be important habitat for many species, which leads to a potential conflict that is important to consider in the planning of green infrastructure.
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| 33. |
- Andreassen, Eva, et al.
(författare)
-
Kokbok för förändringsledare : Metdoder för att stötta engagerade människor att förverkliga idéer
- 2020
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Det här är en kokbok för förändringsledare. Du kan använda denna bok om du ska leda utvecklingsaktiviteter och letar efter bra och beprövade metoder för att leda grupper och processer. Vi beskriver metoderna som vi har använt inom vårt projekt SMICE, i vilket sammanhang metoderna använts och när de olika metoderna fungerat bra. Vår förhoppning med att nedteckna dessa metoder är att du ska inspireras och vågar prova något nytt för att skapa nytta. Vi tror att ett detaljerat sätt att dokumentera metoderna gör dem mer användbara för dig men också för oss själva. Metoderna är graderade efter vilket behov av förkunskap och förberedelser du behöver, från det enklaste, där du kan öppna kokboken och använda metoden på en gång, till metoder som kräver utbildning eller specialistkompetens innan du sätter igång. Boken är indelad i fyra huvuddelar; Starta, Forma, Utveckla och förankra och Bygga vidare. Till dessa delar har vi identifierat metodstöd som kan användas vid en rad olika tillfällen; vid idégenerering, vid idéutveckling, vid affärsutveckling, för att inspirera, för att skapa samsyn och samverkan och för att mobilisera större grupper av människor och organisationer. Något för alla, alltså. Avslutningsvis finner du tips och stöd för att driva dessa utvecklingsprocesser på distans med digitala verktyg i digitala möten. Ska vi sammanfatta någon lärdom av detta arbete så blir det våra nycklar som presenteras på nästa sida. Du kan se dessa nycklar som våra bästa råd för att du ska lyckas med ditt arbete med att leda processer och att ordna möten. Lycka till! Metoderna har testats och utvecklats inom SMICE - Samskapande Mittnordisk Innovationsarena för Cirkulär Ekonomi, ett projekt inom Interreg som pågått 2017-2020.
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| 34. |
- Arias Sarah, Pablo, et al.
(författare)
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Pupil dilation reflects the dynamic integration of audiovisual emotional speech
- 2023
-
Ingår i: Scientific Reports. - 2045-2322. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- Emotional speech perception is a multisensory process. When speaking with an individual we concurrently integrate the information from their voice and face to decode e.g., their feelings, moods, and emotions. However, the physiological reactions—such as the reflexive dilation of the pupil—associated to these processes remain mostly unknown. That is the aim of the current article, to investigate whether pupillary reactions can index the processes underlying the audiovisual integration of emotional signals. To investigate this question, we used an algorithm able to increase or decrease the smiles seen in a person’s face or heard in their voice, while preserving the temporal synchrony between visual and auditory channels. Using this algorithm, we created congruent and incongruent audiovisual smiles, and investigated participants’ gaze and pupillary reactions to manipulated stimuli. We found that pupil reactions can reflect emotional information mismatch in audiovisual speech. In our data, when participants were explicitly asked to extract emotional information from stimuli, the first fixation within emotionally mismatching areas (i.e., the mouth) triggered pupil dilation. These results reveal that pupil dilation can reflect the dynamic integration of audiovisual emotional speech and provide insights on how these reactions are triggered during stimulus perception.
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| 35. |
- Asenjo, Felipe A., et al.
(författare)
-
Semi-relativistic effects in spin-1/2 quantum plasmas
- 2012
-
Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 14, s. 073042-
-
Tidskriftsartikel (refereegranskat)abstract
- Emerging possibilities for creating and studying novel plasma regimes, e. g. relativistic plasmas and dense systems, in a controlled laboratory environment also require new modeling tools for such systems. This motivates theoretical studies of the kinetic theory governing the dynamics of plasmas for which both relativistic and quantum effects occur simultaneously. Here, we investigate relativistic corrections to the Pauli Hamiltonian in the context of a scalar kinetic theory for spin-1/2 quantum plasmas. In particular, we formulate a quantum kinetic theory for the collective motion of electrons that takes into account effects such as spin-orbit coupling and Zitterbewegung. We discuss the implications and possible applications of our findings.
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| 36. |
- Aucouturier, Jean-Julien, et al.
(författare)
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Covert digital manipulation of vocal emotion alter speakers' emotional states in a congruent direction
- 2016
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:4, s. 948-953
-
Tidskriftsartikel (refereegranskat)abstract
- Research has shown that people often exert control over their emotions. By modulating expressions, reappraising feelings, and redirecting attention, they can regulate their emotional experience. These findings have contributed to a blurring of the traditional boundaries between cognitive and emotional processes, and it has been suggested that emotional signals are produced in a goal-directed way and monitored for errors like other intentional actions. However, this interesting possibility has never been experimentally tested. To this end, we created a digital audio platform to covertly modify the emotional tone of participants' voices while they talked in the direction of happiness, sadness, or fear. The result showed that the audio transformations were being perceived as natural examples of the intended emotions, but the great majority of the participants, nevertheless, remained unaware that their own voices were being manipulated. This finding indicates that people are not continuously monitoring their own voice to make sure that it meets a predetermined emotional target. Instead, as a consequence of listening to their altered voices, the emotional state of the participants changed in congruence with the emotion portrayed, which was measured by both self-report and skin conductance level. This change is the first evidence, to our knowledge, of peripheral feedback effects on emotional experience in the auditory domain. As such, our result reinforces the wider framework of self-perception theory: that we often use the same inferential strategies to understand ourselves as those that we use to understand others.
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| 37. |
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| 38. |
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| 39. |
- Bartek, Jiri, Jr., et al.
(författare)
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Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study : Study Protocol for a Multinational Population-Based Consecutive Cohort
- 2019
-
Ingår i: Neurosurgery. - : Ovid Technologies (Wolters Kluwer Health). - 0148-396X .- 1524-4040. ; 84:3, s. 799-803
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUNDTraumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.OBJECTIVETo evaluate postoperative (30-d) mortality in younger vs elderly (70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.METHODS This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.EXPECTED OUTCOMESWe expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.DISCUSSION An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.
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| 40. |
- Bengtsson, Mathilda, et al.
(författare)
-
Metoden ByggF-PST : Tillämpning av ByggaF på tillverkning av prefabricerade småhus i trä. Version 1.0
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Metoden som presenteras i detta dokument är en tillämpning av ByggaF påprefabricerad småhustillverkning av hus med träbaserad stomme kallad:”ByggaF för Prefabricerade småhus med trästomme”, hädanefter omnämnd somByggaF-PST. ByggaF-PST är en metod som säkerställer, dokumenterar ochkommunicerar fuktsäkerheten i hela byggprocessen, från planering tillbruksskede. Metoden innebär ett arbetssätt för att uppfylla samhällets krav påfuktsäkerhet och innehåller rutiner och hjälpmedel för alla aktörer, frånsmåhustillverkare, konsulter, materialleverantörer och entreprenörer.
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| 41. |
- Berggren, Lars, et al.
(författare)
-
Bomben som skakade Sverige
- 2008
-
Ingår i: Ekot från Amalthea. - 9789163332517 ; , s. 19-64
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 42. |
- Bergvall, Ulrika A., 1970-, et al.
(författare)
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Chemical Immobilization of Free-ranging Fallow Deer (Dama dama) : Effect of Needle Length on Induction Time
- 2015
-
Ingår i: Journal of Wildlife Diseases. - : Wildlife Disease Association. - 0090-3558 .- 1943-3700. ; 51:2, s. 484-487
-
Tidskriftsartikel (refereegranskat)abstract
- We evaluated impact of the needle length, sex, and body condition on chemical immobilization induction time in 50 (29 males and 21 females) free-ranging fallow deer (Dama dama) in Sweden, 2006-11. Induction time is probably the single most important factor when immobilizing free-ranging wildlife with the use of a remote drug-delivery system. Induction times should be short to minimize stress and risk of injury, and to ensure that immobilized animals can be found and clinically monitored as soon as possible. We measured the distance between the darting location and where we recovered the immobilized animal and also the time occurring between the two events. We used two types of needles: 2.0 × 30- or 2.0 × 40-mm barbed needles with side ports. The most important result is that a 10-mm-longer dart needle can reduce the retrieval time substantially (>20 min) until an animal is under monitoring. On average after the darting, the retrieval time decreased from 51 to 29 min and the distance decreased from 519 m from the darting location to 294 m. We suggest that a needle length of 40 mm is preferable for immobilization of wild fallow deer, especially for animals in over-average-to-fat body condition.
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| 43. |
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| 44. |
- Blomkvist, Pär, 1961-, et al.
(författare)
-
Systems thinking in Industrial dynamics
- 2016
-
Ingår i: A Dynamic Mind. Perspectives on Industrial Dynamics in Honour of Staffan Laestadius. - : Division of Sustainability and Industrial Dynamics, Department of Industrial Economics and Management, KTH.. ; , s. 45-74
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Bokkapitel (refereegranskat)
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| 45. |
- Blomkvist, Pär, 1961-, et al.
(författare)
-
This is Industrial Dynamics
- 2016
-
Ingår i: A Dynamic Mind. Perspectives on Industrial Dynamics in Honour of Staffan Laestadius. - : Division of Sustainability and Industrial Dynamics, Department of Industrial Economics and Management, KTH..
-
Bokkapitel (refereegranskat)
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| 46. |
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| 47. |
- Brolen, Gabriella, et al.
(författare)
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Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage
- 2010
-
Ingår i: Journal of Biotechnology. - : Elsevier BV. - 1873-4863 .- 0168-1656. ; 145:3, s. 284-294
-
Tidskriftsartikel (refereegranskat)abstract
- Human embryonic stem cells offer a potential unlimited supply for functional hepatocytes, since they can differentiate into hepatocyte-like cells displaying a characteristic hepatic morphology and expressing various hepatic markers. These cells could be used in various applications such as studies of drug metabolism and hepatotoxicity, which however, would require a significant expression of drug metabolizing enzymes. To derive these cells we use a stepwise differentiation protocol where growth- and maturation factors are added. The first phase involves the formation of definitive endoderm. Next, these cells are treated with factors known to promote the induction and proliferation towards hepatic progenitor cell types. In the last phase the cells are terminally differentiated and maturated into functional hepatocyte-like cells. The cultures were characterized by analysis of endodermal or hepatic markers and compared to cultures derived without induction via definitive endoderm. Hepatic functions such as urea secretion, glycogen storage, indocyanine green uptake and secretion, and cytochrome P450-expression and activity were evaluated. The DE-Hep showed a hepatocyte morphology with sub-organized cells and exhibited many liver-functions including transporter activity and capacity to metabolize drugs specific for important cytochrome P450 sub-families. This represents an importantstep in differentiation of hESC into functional hepatocytes. (C) 2009 Elsevier B.V. All rights reserved.
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| 48. |
- Bull, Peter, et al.
(författare)
-
Förstudie obemannade farkoster
- 2012
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Rapport (populärvet., debatt m.m.)abstract
- Obemannade farkoster används allt oftare, och i allt fler roller, i dagens kon- flikter. Denna rapport ger en bred överblick över området militära obemannade farkoster, samt rekommendationer för inriktningen av framtida FoU-satsningar inom området.Överblicken över området har fokus på både system, förmågor och verksam- heter som är relevanta för Försvarsmakten. Genom att låta de insatsförmågor som definieras i FMUP (Försvarsmaktens utvecklingsplan) gå som en röd tråd genom rapporten, både när specifika system diskuteras och när möjliga scena- rier där obemannade farkoster kan vara till nytta beskrivs, har vi försökt hålla både bredd och relevans i dokumentet.Rekommendationerna vilar på en genomgång av de inriktningsdokument som producerats i Försvarsmakten, t.ex. Perspektivplanneringen och FMUP, besök vid de enheter som dagligen använder obemannade farkoster, UAV-enheten i Karlsborg och Swedec i Eksjö, samt den områdesöverblick som nämns ovan. Slutsatserna är att den effektivaste kompetensuppbyggnaden och kunskapsöver- föringen fås om man skapar breda tvärvetenskapliga projekt inom respektive systemkategori (UAV, UGV, etc) med nära kontakter till materielförsörjnings- processen och perspektivplaneringen. Dessa kan samla kompetensen inom FHS och FOI, övervaka forskningsfronten genom att bevaka tävlingar, konferenser samt delta i internationella samarbeten, samt överföra det samlade resultaten till Försvarsmakten genom demonstrationer av verkliga eller simulerade delsy- stem och interaktiva simuleringar av hela system. Just systemsimuleringar kan göras särskilt realistiska, eftersom interaktionen med de riktiga obemannade systemen till stor del sker igenom kontrollstationernas datorer. På så sätt ska- pas en känsla för både hot och möjligheter med de nya systemen, vilket gagnar både taktikutveckling och materielprocesser.
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| 49. |
- Bygdéus, Pia, 1963-
(författare)
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Uttryck genom handling : Medierande verktyg i körledararbete med barn och unga
- 2012
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The role of the choir leader is a complex one. When working with a choir, choir leaders often use several aspects of their professional role. The aim of this qualitative study is to describe, verbalise and make visible the mediating tools that choir directors working with children and youth choirs use. In a longitude study, four choir leaders were observed closely while working with their choirs. They also took part in semi-structured interviews. The empirical data material consists of observation notes, reflective writing, individualinterviews, focus conversations and videotapes. Analysed from a sociocultural perspective, the result points to eight groups of mediating tools: a) a listening attitude towards the choir, with the music in focus; b) a variation in ways of working with the choir, where a variety of physical tools are used; c) the use of musical routines; d) the choir director acting as a role model in shaping musicalexpression with the group; e) a concentrated cooperation with the choir through short and expressive instructions; f) reflection in practice by planning and self-evaluation; g) storytelling, which results in memory training, stimulation of the imagination and the sharing of common experience, and h) the use of target images expressed as visions, small/big goals or jointly stated, communicated targets. The choir directors who participated in the study use a variety of approaches and ways of working as a strategy for communicating and working with child and youth choirs.
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| 50. |
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