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1.	Beal, Jacob, et al. (författare) Robust estimation of bacterial cell count from optical density 2020 Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1 Tidskriftsartikel (refereegranskat)abstract Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
2.	Gustavsson, Anders, et al. (författare) Corrigendum to “Cost of disorders of the brain in Europe 2010” [Eur. Neuropsychopharmacol. 21 (2011) 718–779] 2012 Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 22:3, s. 237-238 Tidskriftsartikel (refereegranskat)abstract The spectrum of disorders of the brain is large, covering hundreds of disorders that are listed in either the mental or neurological disorder chapters of the established international diagnostic classification systems. These disorders have a high prevalence as well as short- and long-term impairments and disabilities. Therefore they are an emotional, financial and social burden to the patients, their families and their social network. In a 2005 landmark study, we estimated for the first time the annual cost of 12 major groups of disorders of the brain in Europe and gave a conservative estimate of €386 billion for the year 2004. This estimate was limited in scope and conservative due to the lack of sufficiently comprehensive epidemiological and/or economic data on several important diagnostic groups. We are now in a position to substantially improve and revise the 2004 estimates. In the present report we cover 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items. We therefore present much improved cost estimates. Our revised estimates also now include the new EU member states, and hence a population of 514 million people.
3.	Lindgren, Moa, et al. (författare) Type IV Collagen in Human Colorectal Liver Metastases—Cellular Origin and a Circulating Biomarker 2022 Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:14 Tidskriftsartikel (refereegranskat)abstract Circulating type IV collagen (cCOL IV) is a potential biomarker for patients with colorectal liver metastases (CLM) who present with elevated levels of COL IV in both CLM tissue and circulation. This study aimed to establish the cellular origin of elevated levels of COL IV and analyze circulating COL IV in CLM patients. The cellular source was established through in situ hybridization, immunohistochemical staining, and morphological evaluation. Cellular expression in vitro was assessed by immunofluorescence. Tissue expression of COL IV-degrading matrix metalloproteinases (MMPs)-2, -7, -9, and -13 was studied with immunohistochemical staining. Plasma levels of COL IV in CLM patients and healthy controls were analyzed with ELISA. This study shows that cancer-associated fibroblasts (CAFs) express COL IV in the stroma of CLM and that COL IV is expressed in vitro by fibroblasts but not by tumor cells. MMP-2, -7, -9, and -13 are expressed in CLM tissue, mainly by hepatocytes and immune cells, and circulating COL IV is significantly elevated in CLM patients compared with healthy controls. Our study shows that stromal cells, not tumor cells, produce COL IV in CLM, and that circulating COL IV is elevated in patients with CLM.
4.	Moberg, Christina, et al. (författare) De unga gör helt rätt när de stämmer staten 2022 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)abstract 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
5.	Stage, Christina, et al. (författare) Viktning av delproven i högskoleprovet 2006 Rapport (övrigt vetenskapligt/konstnärligt)abstract The Swedish Scholastic Assessment Test (SweSAT) presently consists of five subtests with a total of 122 items. Each correct answer gives one point, and these points are summed to a total score. After the test, the total score is transformed to a standardized score on a scale from 0.0 to 2.0. Three of the subtests measure verbal ability (vocabulary with 40 items, Swedish reading comprehension with 20 items, and English reading comprehension with 20 items) and two subtests measure quantitative ability (data sufficiency with 22 items and interpretation of diagrams, tables and maps with 20 items). Hence the verbal part of the test amounts to 66 percent of the total test. It has been suggested that the predictive power of the test might be improved if the test was composed of two separately scored parts, one measuring verbal and the other measuring logical ability. These parts could be weighted differently for application to different educational programs. In order to examine the effect of a changed weighting of the parts of SweSAT for different subgroups of examinees a simulation study was performed. Two different weighting models were used. In one weighting model the verbal part constituted 59 percent, and the logical part constituted 41 percent of the total test. In the other model the verbal part constituted 49 percent and the logical part 51 percent. These models were used on the results of the 62 700 examinees, who took part in the test, administered in spring 2000. The results regarding gender were, as expected, that the weighting models favoured males. Regarding age groups, the younger examinees (below 25 years) were favoured. Regarding different educational groups those with low education and those with higher education were disfavoured, while the big group of examinees who had finished upper secondary school and nothing else, were favoured. And finally regarding social groups the weighting of the two parts hardly changed the results at all. The conclusion was that a changed weighting of different parts of the test would not have any unduly unfavourable consequences.
6.	Abdallah, J, et al. (författare) Rapidity-alignment and p(T) compensation of particle pairs in hadronic Z(0) decays 2002 Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 533:3-4, s. 243-252 Tidskriftsartikel (refereegranskat)abstract Observation is made of rapidity-alignment of K+K- and (p) over barp pairs which results from their asymmetric orientation in rapidity, with respect to the direction from primary quark to antiquark. The K+K- and (p) over barp data are consistent with predictions from the fragmentation string model. However, the (p) over barp data strongly disagree with the conventional implementation of the cluster model. The non-perturbative process of 'gluon splitting to diquarks' has to be incorporated into the cluster model for it to agree with the data. Local conservation of PT between particles nearby in rapidity (i.e., p(T) compensation) is analysed with respect to the thrust direction for pi(+)pi(-), K+K-, and (p) over barp pairs. In this case, the string model provides fair agreement with the data. The cluster model is incompatible with the data for all three particle pairs. The model with its central premiss of isotropically-decaying clusters predicts a p(T) correlation not seen in the data. (C) 2002 Elsevier Science B.V. All rights reserved.
7.	Abdallah, J, et al. (författare) Search for charged Higgs bosons in e(+)e(-) collisions root s=189-202 GeV 2002 Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 525:1-2, s. 17-28 Tidskriftsartikel (refereegranskat)abstract A search for pair-produced charged Higgs bosons was performed in the high energy data collected by the DELPHI detector at LEP II at centre-of-mass energies from 189 GeV to 202 GeV. The three different final states, taunutaunu, c (s) over bar(c) over bars and c (s) over bar taunu were considered. New methods were applied to reject wrong hadronic jet pairings and for the tau identification, where a discriminator based on tau polarisation and polar angles was used. No excess of data compared to the expected Standard Model processes was observed and the existence of a charged Higgs boson with mass lower than 71.5 GeV/c(2) is excluded at the 95% confidence level. (C) 2002 Published by Elsevier Science B.V.
8.	Abdallah, J, et al. (författare) Searches for neutral Higgs bosons in e(+)e(-), collisions from root s=191.6 to 201.7 GeV 2002 Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 23:3, s. 409-435 Tidskriftsartikel (refereegranskat)abstract Neutral Higgs bosons of the Standard Model (SM) and the Minimal Supersymmetric Standard Model (MSSM) were searched for in the data collected in 1999 by the DELPHI experiment at centre-of-mass energies between 191.6 and 201.7 GeV with a total integrated luminosity of 228 pb(-1). These analyses, in combination with our results at lower energies, set 95% confidence level lower mass bounds on the Standard Model Higgs boson (107.3 GeV/c(2)) and on the lightest neutral scalar (85.9 GeV/c(2)) and neutral pseudoscalar (86.5 GeV/c(2)) Higgs bosons in representative scans of the MSSM parameter space. An extended scan of the MSSM parameter space was also performed to test the robustness of these limits.
9.	Abdallah, J, et al. (författare) Study of inclusive J/psi production in two-photon collisions at LEP II with the DELPHI detector 2003 Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 565:1-4, s. 76-86 Tidskriftsartikel (refereegranskat)abstract Inclusive J/psi production in photon-photon collisions has been observed at LEP II beam energies. A clear signal from the reaction gammagamma --> J/psi + X is seen. The number of observed N(J/psi --> mu(+)mu(-)) events is 36+/-7 for an integrated luminosity of 617 pb(-1), yielding a cross-section of sigma(J/psi + X) = 45+/-9(stat) +/- 17(syst) pb. Based on a study of the event shapes of different types of gammagamma processes in the PYTHIA program, we conclude that (74+/-22) % of the observed J/psi events are due to 'resolved' photons, the dominant contribution of which is most probably due to the gluon content of the photon. (C) 2003 Published by Elsevier B.V.
10.	Ahl Jonsson, Christina, et al. (författare) The lived experience of the early postoperative period after colorectal cancer surgery 2011 Ingår i: European Journal of Cancer Care. - : Wiley. - 0961-5423 .- 1365-2354. ; 20:2, s. 248-256 Tidskriftsartikel (refereegranskat)abstract Colorectal cancer is one of the most common cancer diagnoses and undergoing colorectal cancer surgery is reported to be associated with physical symptoms and psychological reactions. Social support is described as important during the postoperative period. The purpose of this paper was to describe how patients experience the early postoperative period after colorectal cancer surgery. Interviews according a phenomenological approach were performed with 13 adult participants, within 1 week after discharge from hospital. Data were collected from August 2006 to February 2007. Analysis of the interview transcripts was conducted according to Giorgi. The essence of the phenomenon was to regain control over ones body in the early postoperative period after colorectal cancer surgery. Lack of control, fear of wound and anastomosis rupture, insecurity according to complications was prominent findings. When caring for these patients it is a challenge to be sensitive, encourage and promote patients to express their feelings and needs. One possibility to empower the patients and give support could be a follow up phone call within a week after discharge.
11.	Ahlén, Ingemar, et al. (författare) Nya järnvägen hotar unikt naturområde 2002 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)
12.	Ahlén, Ingemar, et al. (författare) Nya järnvägen hotar unikt naturområde 2002 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
13.	Ahlstrand, Christina, 1957, et al. (författare) Reliabilitetstestning av Purdue Pegboard® (finmotoriktest). 2009 Rapport (övrigt vetenskapligt/konstnärligt)abstract I MQ-FAS studien, vars syfte var att ändra muskelspänningsmönstret hos kvinnor med kroniska nackbesvär, ingick ett besticktorkningsmoment som en standardiserad arbetsuppgift i hemmet. För validering av denna besticktorkning har en pilotstudie genomförts, 12 personer torkade bestick vid två tillfällen. I studien, som utfördes av 2 testledare, ingick även ett finmotorikstest (Purdue Pegboard), ansträngningsskattning (Borg RPE-skalan) samt ett frågeformulär. Detta test kan med vissa justeringar troligen vara användbart som ett mått på arbetsförmåga av övre extremiteter vid utförande av arbetssyssla i hemmet, och jämföra individ med sig själv, för att mäta om funktionsnedsättning eller ökning har skett. Dock skall poängteras att detta var en pilotstudie och ytterligare studie av reliabilitet och validitet rekommenderas innan testet används i stor utsträckning för att mäta om funktionsnedsättning eller ökning har skett.
14.	Aldman, Lili-Annè, 1955- (författare) En merkantilistisk början : Stockholms textila import 1720–1738 2008 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The purpose of this thesis is to, from an institutional approach, study how the Stockholm importers within the textile sector adapted their foreign trade to the change in economic policy 1720 through 1738. The focus is to investigate to what extent the introduction of new laws, regulations etc. can be an explanation for what happened to Stockholm’s foreign trade, mainly imports, particularly textile imports during the period. It is mainly the economic policies that had been enacted during the Hornian government and their effects that have been studied. This is a period that has seldom been studied in other research. This thesis begins when the Russian raids were over. This was a year when the foreign trade still was relatively free and was untouched by the 17th century’s regulations. After 1721 the policies that would be introduced to increase Sweden's level of self-sufficiency and strengthen ties with the North Sea area had several components. Besides the economic policy, the main sources for the thesis are the city toll records. The trade policies in the shape of tolls and fees, import and consumption bans etc. and the commercial policies together became different kinds of political tools used for several purposes. The conclusion of this thesis is that the economic policies made the Stockholm importers adapt their trade to the change. The import bans and sumptuary laws had an effect. The economic policies gave rise to an increase in the import of textile raw materials. The rise in toll costs and import fees contributed to displacing the foreign trade towards other areas. The change in the economic policies was successful in the sense that it gave rise to new conditions for domestic production within the textile sector and forced Stockholm's importers to adapt their foreign trade.
15.	Alkmark, Mårten, 1973, et al. (författare) God vetenskaplig grund för att erbjuda kvinnor igångsättning i vecka 41 2021 Ingår i: Dagens Nyheter (DN Debatt). - 1101-2447. ; :2021-08-06 Tidskriftsartikel (populärvet., debatt m.m.)
16.	Andersson, Helene, et al. (författare) Consecutive microcontact printing - ligands for asymmetric catalysis in silicon channels 2001 Ingår i: Sensors and actuators. B, Chemical. - 0925-4005 .- 1873-3077. ; 79:1, s. 78-84 Tidskriftsartikel (refereegranskat)abstract Consecutive microcontact printing ( mu CP) has been developed to enable multiple functionalization of silicon surfaces, such as the immobilization of chiral ligands. The technique involves two subsequent printing steps using unstructured poly(methylsiloxane) stamps. The pattern is already defined on the substrate, consisting of etched channels. Hence, no precise alignment is needed between the two printing steps. A carboxylic acid group containing reagent was initially printed onto the silicon oxide surface and transformed to an anhydride. hi the second printing step an ester bond was formed with the hydroxy-functionalized ligand. The formed molecular layers were evaluated by contact angle measurements, scanning electron microscopy (SEM) and electron spectroscopy for chemical analysis (ESCA), indicating that the consecutive mu CP was successful. Initially, printing was performed on planar silicon surfaces but to realize a flow-through microfluidic device for high throughput screening a mu CP technique was developed for etched channels. To verify the technique, hydrophobic valves consisting of octadecyltrichlorosilane were formed using mu CP in deep reactive ion etched channels (50 mum wide and 50 mum deep). The printed hydrophobic patches were visualized by SEM and functioned well. Finally, the consecutive mu CP technique was applied to immobilize the ligand in the channels. The channels were then sealed with a low-temperature bonding technique using an adhesive PDMS film, which does not destroy the printed ligand. In this study mu CP is used in a novel manner. It enables a convenient method for performing complex surface modification of etched structures, which is a frequently appearing problem in biochemical microfluidic systems.
17.	Andersson, Helene, et al. (författare) Patterned self-assembled beads in silicon channels 2001 Ingår i: Electrophoresis. - 0173-0835 .- 1522-2683. ; 22:18, s. 3876-3882 Tidskriftsartikel (refereegranskat)abstract A novel technique enabling selective bead trapping in microfluidic devices without the use of physical barriers is presented in this paper. It is a fast, convenient and simple method, involving microcontact printing and self-assembly, that can be applied to silicon, quartz or plastic substrates. In the first step, channels are etched in the substrate. The surface chemistry of the internal walls of the channels is then modified by microcontact printing. The chip is submerged in a bead slurry where beads self-assemble based on surface chemistry and immobilize on the internal walls of the channels. Silicon channels (100 mum wide and 50 mum deep) have been covered with monolayers of streptavidin-, amino- and hydroxy-functionalized microspheres and resulted in good surface coverage of beads on the channel walls. A high-resolution pattern of lines of self-assembled streptavidin beads, as narrow as 5 mum, has also been generated on the bottom of a 500 mum wide and 50 mum deep channel. Flow tests were performed in sealed channels with the different immobilized beads to confirm that the immobilized beads could withstand the forces generated by water flowing in the channels. The presented results indicate that single beads can be precisely positioned within microfluidic devices based on self-assembly which is useful as screening and analysis tools within the field of biochemistry and organic chemistry.
18.	Andersson, Helene, et al. (författare) Self-assembled and self-sorted array of chemically active beads for analytical and biochemical screening 2002 Ingår i: Talanta. - 0039-9140 .- 1873-3573. ; 56:2, s. 301-308 Tidskriftsartikel (refereegranskat)abstract A technique for generating a general screening platform consisting of dots of immobilized beads on silicon has been developed via self-sorting and -assembly of different kinds of beads. The dots are defined by a teflon-like film, which due to its hydrophobic characteristics also prevents cross-contamination of liquid from different dots. To enable functionalization of individual dots with different target molecules simultaneously a new way of microcontact printing has been explored where different target solutions are printed in parallel using one stamp. In order to show that this platform can be designed for both biochemical assays and organic chemistry, streptavidin-, amino- and hydroxy-functionalized beads have been self-sorted and -assembled both on separate and common platforms. The self-sorting and -arrangement are based on surface chemistry only, which has not previously been reported. Beads of different sizes and material have successfully been immobilized in line patterns as narrow as 5 mum. Besides silicon, quartz and polyethylene have also been used as substrates.
19.	Berg, Christina, 1963, et al. (författare) Matkonsumtionen och hälsan 2008 Ingår i: Konsumtionsrapporten 2008. - Göteborg : University of Gothenburg. ; , s. 30-33 Bokkapitel (övrigt vetenskapligt/konstnärligt)
20.	Berg, Christina, 1963, et al. (författare) Perceptions and reasons for choice of fat- and fibre-containing foods by Swedish schoolchildren 2003 Ingår i: Appetite. ; 40, s. 61-67 Tidskriftsartikel (refereegranskat)abstract Department of Home Economics, Göteborg University, Box 122 04, SE 402 42, Göteborg, Sweden. christina.berg@ped.gu.se This study investigated schoolchildren's breakfast choices focusing on their reported usual intake and perceptions of fat-reduced or fibre-enriched alternatives. A total of 184 eleven- to fifteen-year-old were asked to participate, and 181 completed the study. Using pictures of food items, the children were instructed to reproduce their usual breakfast, and then breakfasts that would be: healthy, tasty, consumed by their parents, or approved by their parents. Participants' usual breakfast included breads and breakfast cereals containing a higher fibre content than that of the breakfast reported as most palatable. Their usual breakfast also contained products with less fibre than was the case for their healthy or perceived parental norm breakfasts. This may be interpreted as evidence that high-fibre bread and breakfast cereals are perceived as healthy but that consumption of these products is limited by palatability. In contrast to the ambivalence towards cereal products, corresponding disagreements between breakfasts were not observed for milk, and only a small systematic disagreement was observed for spread. Thus, the majority consumed the kind of milk and spread perceived as being healthy, tasty and parentally sanctioned despite the fact that full-fat products were frequently consumed. In conclusion, the results suggest that taste may be a barrier to consumption of high-fibre products, while consumption of low-fat products appears to be impeded by health beliefs. PMID: 12631506 [PubMed - indexed for MEDLINE]
21.	Berg, Christina, 1963, et al. (författare) Relation between breakfast food choices and knowledge of dietary fat and fiber among Swedish schoolchildren. 2002 Ingår i: The Journal of adolescent health : official publication of the Society for Adolescent Medicine. - 1054-139X. ; 31:2, s. 199-207 Tidskriftsartikel (refereegranskat)abstract PURPOSE: To investigate dietary knowledge and beliefs of schoolchildren, in relationship to breakfast choices, with specific attention to fat and fiber content. METHODS: Food choice and perceptions were studied by interviews using the "stacking box methodology". Youth (n = 181) aged 11-15 years were instructed to select food items among photographs of breakfast foods. In addition to choosing their own typical breakfasts, they were asked to exchange foods in hypothetical breakfasts to create meals with less fat and more fiber. The interview also dealt with recent changes in breakfast habits, and perceptions of healthy breakfasts, dietary fat, and foods rich in fiber. Data were analyzed by logistic regression. RESULTS: Knowledge concerning sources and health attributes of dietary fiber was associated with usual consumption of bread and breakfast cereals rich in fiber. In a similar way, a positive attitude toward limited fat intake predicted consumption of reduced-fat milk products. However, no association was observed between food choices and knowledge of a food-packaging symbol indicating low-fat and fiber-enriched foods. CONCLUSION: Lack of awareness of, and knowledge about, healthy eating may be important barriers to the development of health promoting food habits by schoolchildren.
22.	Berg, Christina, 1963, et al. (författare) Sources of bias in a dietary survey of children. 1998 Ingår i: European journal of clinical nutrition. - 0954-3007. ; 52:9, s. 663-7 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: To compare non-responders and responders to a dietary survey with respect to demographic variables and intention to choose selected breakfast foods, and to examine if there was any systematic change in number of food items reported during a 7 d recording period. DESIGN: Cross-sectional survey. SETTING: Mölndal, Sweden. SUBJECTS: All pupils in 5th, 7th and 9th grades in the municipality were asked to complete a questionnaire during school hours. All those present (n = 1584, 92% of total) answered questions about lifestyle factors and about intentions, attitudes and beliefs concerning high-fibre bread and milk with varying fat content. All subjects in the initial sample were asked to fill in a 7 d record of food consumed. Acceptable food records were completed by 69% of the initial participants. RESULTS: Subjects not completing the food record differed significantly from participants with respect to demographic, lifestyle and dietary factors. Dropout was more common among those who reported not usually eating breakfast and among those intending to drink whole milk for breakfast. A decline in reported food items during the recording period was also observed. CONCLUSIONS: Two sources of bias were observed here, one indicating significant differences between non-participants and participants, the other suggesting the presence of a time-dependent trend in number of recorded foods. It is likely such biases are present in other dietary surveys involving schoolchildren, and should be taken into consideration in the design, analysis and interpretation of such studies.
23.	Berg, Christina, 1963, et al. (författare) Understanding choice of milk and bread for breakfast among Swedish children aged 11-15 years: an application of the Theory of Planned Behaviour. 2000 Ingår i: Appetite. - : Elsevier BV. - 0195-6663. ; 34:1, s. 5-19 Tidskriftsartikel (refereegranskat)abstract The present study examined the influences of attitudes, social norms, perceived control and underlying beliefs on 11 to 15-year-olds' breakfast choices of milk with different fat content and high-fibre bread. All pupils in the 5th, 7th and 9th grades in Mölndal community (N=1730), Sweden, were asked to complete a questionnaire based on the Theory of Planned Behaviour. Two weeks later, they were asked to fill in a 7-day record of food consumed for breakfast. Consumption of milk and high-fibre bread was predicted from intentions, and for milk also by perceived behavioural control. Intentions were influenced by attitudes, perceptions of significant others' preferences, and perceived control. In addition, perception of the parents' consumption (descriptive norm) of the specific food played an important role. Attitudes, norms and perceived control predicted intentions to a similar extent in each age group. Attitudes to the consumption of milk and high fibre bread were influenced by beliefs about their sensory and health aspects. Females and the oldest children had greater knowledge about the healthier alternatives and the oldest children had a tendency to choose healthier options.
24.	Borgmästars, Emmy, et al. (författare) Circulating tissue polypeptide-specific antigen in pre-diagnostic pancreatic cancer samples 2021 Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:21 Tidskriftsartikel (refereegranskat)abstract Early detection of pancreatic ductal adenocarcinoma (PDAC) is challenging, and late diagnosis partly explains the low 5-year survival. Novel and sensitive biomarkers are needed to enable early PDAC detection and improve patient outcomes. Tissue polypeptide specific antigen (TPS) has been studied as a biomarker in PDAC diagnostics, and it has previously been shown to reflect clinical status better than the ‘golden standard’ biomarker carbohydrate antigen 19-9 (CA 19-9) that is most widely used in the clinical setting. In this cross-sectional case-control study using pre-diagnostic plasma samples, we aim to evaluate the potential of TPS as a biomarker for early PDAC detection. Furthermore, in a subset of individuals with multiple samples available at different time points before diagnosis, a longitudinal analysis was used. We assessed plasma TPS levels using enzyme-linked immunosorbent assay (ELISA) in 267 pre-diagnostic PDAC plasma samples taken up to 18.8 years before clinical PDAC diagnosis and in 320 matched healthy controls. TPS levels were also assessed in 25 samples at PDAC diagnosis. Circulating TPS levels were low both in pre-diagnostic samples of future PDAC patients and in healthy controls, whereas TPS levels at PDAC diagnosis were significantly increased (odds ratio 1.03; 95% confidence interval: 1.01–1.05) in a logistic regression model adjusted for age. In conclusion, TPS levels increase late in PDAC progression and hold no potential as a biomarker for early detection.
25.	Borgmästars, Emmy, et al. (författare) Metabolomics for early pancreatic cancer detection in plasma samples from a Swedish prospective population-based biobank Annan publikation (övrigt vetenskapligt/konstnärligt)
26.	Borgmästars, Emmy, et al. (författare) Metabolomics for early pancreatic cancer detection in plasma samples from a Swedish prospective population-based biobank 2024 Ingår i: Journal of Gastrointestinal Oncology. - : AME Publishing Company. - 2078-6891 .- 2219-679X. ; 15:2, s. 755-767 Tidskriftsartikel (refereegranskat)abstract Background: Pancreatic ductal adenocarcinoma (pancreatic cancer) is often detected at late stages resulting in poor overall survival. To improve survival, more patients need to be diagnosed early when curative surgery is feasible. We aimed to identify circulating metabolites that could be used as early pancreatic cancer biomarkers.Methods: We performed metabolomics by liquid and gas chromatography-mass spectrometry in plasma samples from 82 future pancreatic cancer patients and 82 matched healthy controls within the Northern Sweden Health and Disease Study (NSHDS). Logistic regression was used to assess univariate associations between metabolites and pancreatic cancer risk. Least absolute shrinkage and selection operator (LASSO) logistic regression was used to design a metabolite-based risk score. We used receiver operating characteristic (ROC) analyses to assess the discriminative performance of the metabolite-based risk score.Results: Among twelve risk-associated metabolites with a nominal P value <0.05, we defined a risk score of three metabolites [indoleacetate, 3-hydroxydecanoate (10:0-OH), and retention index (RI): 2,745.4] using LASSO. A logistic regression model containing these three metabolites, age, sex, body mass index (BMI), smoking status, sample date, fasting status, and carbohydrate antigen 19-9 (CA 19-9) yielded an internal area under curve (AUC) of 0.784 [95% confidence interval (CI): 0.714–0.854] compared to 0.681 (95% CI: 0.597–0.764) for a model without these metabolites (P value =0.007). Seventeen metabolites were significantly associated with pancreatic cancer survival [false discovery rate (FDR) <0.1].Conclusions: Indoleacetate, 3-hydroxydecanoate (10:0-OH), and RI: 2,745.4 were identified as the top candidate biomarkers for early detection. However, continued efforts are warranted to determine the usefulness of these metabolites as early pancreatic cancer biomarkers.
27.	Borgmästars, Emmy, et al. (författare) Metabolomics for early pancreatic cancer detection in plasma samples from a Swedish prospective population-based biobank 2024 Ingår i: Journal of Gastrointestinal Oncology. - : AME Publishing Company. - 2078-6891 .- 2219-679X. ; 15:2, s. 755-767 Tidskriftsartikel (refereegranskat)abstract Background: Pancreatic ductal adenocarcinoma (pancreatic cancer) is often detected at late stages resulting in poor overall survival. To improve survival, more patients need to be diagnosed early when curative surgery is feasible. We aimed to identify circulating metabolites that could be used as early pancreatic cancer biomarkers.Methods: We performed metabolomics by liquid and gas chromatography-mass spectrometry in plasma samples from 82 future pancreatic cancer patients and 82 matched healthy controls within the Northern Sweden Health and Disease Study (NSHDS). Logistic regression was used to assess univariate associations between metabolites and pancreatic cancer risk. Least absolute shrinkage and selection operator (LASSO) logistic regression was used to design a metabolite-based risk score. We used receiver operating characteristic (ROC) analyses to assess the discriminative performance of the metabolite-based risk score.Results: Among twelve risk-associated metabolites with a nominal P value <0.05, we defined a risk score of three metabolites [indoleacetate, 3-hydroxydecanoate (10:0-OH), and retention index (RI): 2,745.4] using LASSO. A logistic regression model containing these three metabolites, age, sex, body mass index (BMI), smoking status, sample date, fasting status, and carbohydrate antigen 19-9 (CA 19-9) yielded an internal area under curve (AUC) of 0.784 [95% confidence interval (CI): 0.714–0.854] compared to 0.681 (95% CI: 0.597–0.764) for a model without these metabolites (P value =0.007). Seventeen metabolites were significantly associated with pancreatic cancer survival [false discovery rate (FDR) <0.1].Conclusions: Indoleacetate, 3-hydroxydecanoate (10:0-OH), and RI: 2,745.4 were identified as the top candidate biomarkers for early detection. However, continued efforts are warranted to determine the usefulness of these metabolites as early pancreatic cancer biomarkers.
28.	Bosch-Sijtsema, Petra, 1971, et al. (författare) Hur vi använder digitala tekniker. En framtidsspaning i byggbranschen 2019 Rapport (övrigt vetenskapligt/konstnärligt)abstract Detta forskningsprojekt har finansierats av CMB (Centrum för Management i Byggsektorn). Forskningsprojektet syftar till att identifiera digitala trender i den svenska byggbranschen. Det globala samhället är just nu inne i ett paradigmskifte, på samma sätt som samhället förändrades från ett jordbrukssamhälle till ett industrialiserat samhälle, ser vi nu en övergång från manuellt hanterad information till uppkopplad och digital; och i vissa fall ett samhälle som får se att den mänskliga intelligensen inte alltid är överlägsen. Denna omställning presenterar ett antal nya möjligheter för företag och organisationer men ställer också nya krav och efterfrågar ny kompetens. Detta utmanar byggbranschen och dess aktörer men öppnar upp möjligheten till ökad effektivitet, hållbarhet och konkurrenskraft. Under de senaste tio åren har få prognosstudier utförts för byggbranschen och med tanke på den snabba teknikutvecklingen är det relevant att studera dess nuvarande användning och potentiella möjligheter inom byggbranschen. Genom detta projekt vill vi försöka ge en ögonblicksbild av förståelsen för och användandet av ett antal utvalda digitala tekniker inom byggbranschen. Samtidigt vill vi också skapa en ökad medvetenhet om teknikerna för att på så sätt stötta branschen i dess strävan mot att digitaliseras. Projektet har följande delmål: 1. Kartlägga och analysera ett urval digitala tekniker som kommer att påverka byggbranschen. 2. Att för byggbranschen diskutera och analysera de digitala teknikerna och deras konsekvenser med hjälp av representanter verksamma inom branschen.
29.	Bosch-Sijtsema, Petra, 1971, et al. (författare) The hype factor of digital technologies in AEC 2021 Ingår i: Construction Innovation. - 1477-0857 .- 1471-4175. ; 21:4, s. 899-916 Tidskriftsartikel (refereegranskat)abstract Purpose – This paper aims to focus on 11 digital technologies (i.e. building information modeling, artificial intelligence and machine learning, 3D scanning, sensors, robots/automation, digital twin, virtual reality, 3D printing, drones, cloud computing and self-driving vehicles) that are portrayed in future trend reports and hype curves. The study concentrates on the current usage and knowledge of digital technologies in the Swedish architecture, engineering and construction (AEC) industry to gain an insight in the possible expectations and future trajectory of these digital technologies. Design/methodology/approach – The study applies an abductive approach which is based on three different types of methods. These methods are a literature and document study which focused on 11 digital technologies, two workshops with industry (13 participants) and an online survey (N = 84). Findings – The paper contributes to a current state analysis of the Swedish AEC industry concerning digital technologies and discusses the trajectory of these technologies for the AEC industry. The paper identifies hype factors, in which the knowledge of a digital technology is related to its usage. From the hype factors, four zones that show different stages of digital technology usage and maturity in the industry are induced. Originality/value – The contribution of the paper is twofold. The paper shows insight into opportunities, the current barriers, use and knowledge of digital technologies for the different actors in the AEC industry. Furthermore, the study shows that the AEC industry is behind the traditional Gartner hype curves and contributes with defining four zones for digital technologies for the Swedish AEC industry: confusion, excitement, experimentation and integration.
30.	Brauner, Susanna, et al. (författare) H1N1 vaccination in Sjogren's syndrome triggers polyclonal B cell activation and promotes autoantibody production 2017 Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:10, s. 1755-1763 Tidskriftsartikel (refereegranskat)abstract ObjectivesVaccination of patients with rheumatic disease has been reported to result in lower antibody titres than in healthy individuals. However, studies primarily include patients on immunosuppressive therapy. Here, we investigated the immune response of treatment-naive patients diagnosed with primary Sjogren's syndrome (pSS) to an H1N1 influenza vaccine.Methods Patients with Sjogren's syndrome without immunomodulatory treatment and age-matched and gender-matched healthy controls were immunised with an H1N1 influenza vaccine and monitored for serological and cellular immune responses. Clinical symptoms were monitored with a standardised form. IgG class switch and plasma cell differentiation were induced in vitro in purified naive B cells of untreated and hydroxychloroquine-treated patients and healthy controls. Gene expression was assessed by NanoString technology.ResultsSurprisingly, treatment-naive patients with Sjogren's syndrome developed higher H1N1 IgG titres of greater avidity than healthy controls on vaccination. Notably, off-target B cells were also triggered resulting in increased anti-EBV and autoantibody titres. Endosomal toll-like receptor activation of naive B cells in vitro revealed a greater propensity of patient-derived cells to differentiate into plasmablasts and higher production of class switched IgG. The amplified plasma cell differentiation and class switch could be induced in cells from healthy donors by preincubation with type 1 interferon, but was abolished in hydroxychloroquine-treated patients and after in vitro exposure of naive B cells to chloroquine.ConclusionsThis comprehensive analysis of the immune response in autoimmune patients to exogenous stimulation identifies a mechanistic basis for the B cell hyperactivity in Sjogren's syndrome, and suggests that caution is warranted when considering vaccination in non-treated autoimmune patients.
31.	Brauner, Susanna, et al. (författare) Hyperreactive B Cells Upon Endosomal TLR Triggering Underlying Primary Sjogren's Syndrome 2012 Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 76:2, s. 199-200 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
32.	Burström, Lage, et al. (författare) Daily text messages used as a method for assessing low back pain among workers 2016 Ingår i: Journal of Clinical Epidemiology. - : Elsevier BV. - 0895-4356 .- 1878-5921. ; :70, s. 45-51 Tidskriftsartikel (refereegranskat)abstract OBJECTIVES: To evaluate a method for collecting data concerning low back pain (LBP) using daily text messages and to characterize the reported LBP in terms of intensity, variability, and episodes.STUDY DESIGN AND SETTING: We conducted a cohort study of LBP among workers used by a mining company. The participants were asked to answer the question "How much pain have you had in your lower back in the last 24 hours on a scale from 0 to 10, where 0 = no pain and 10 = the worst pain imaginable" once a day for 5 weeks, with this process being repeated 6 months later.RESULTS: A total of 121 workers participated in the first period of data collection, and 108 participated in the second period. The daily response rate was 93% for both periods, and cluster analysis was shown to be a feasible statistical method for clustering LBP into subgroups of low, medium, and high pain. The daily text messages method also worked well for assessing the episodic nature of LBP.CONCLUSION: We have demonstrated a method for repeatedly measuring of LBP using daily text messages. The data permitted clustering into subgroups and could be used to define episodes of LBP.
33.	Carlsson, Christina, 1968, et al. (författare) Dancing DNA in Capillary Solution Electrophoresis 1995 Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 117:13, s. 3871-3872 Tidskriftsartikel (refereegranskat)
34.	Carlsson, Christina, 1968, et al. (författare) Influence of optical probing with YOYO on the electrophoretic behavior of the DNA molecule 1996 Ingår i: Electrophoresis. - 0173-0835 .- 1522-2683. ; 17, s. 642-651 Tidskriftsartikel (refereegranskat)
35.	Carlsson, Christina, 1968, et al. (författare) OPTICAL AND PHOTOPHYSICAL PROPERTIES OF THE OXAZOLE YELLOW DNA PROBES YO AND YOYO 1994 Ingår i: Journal of Physical Chemistry. - : American Chemical Society (ACS). - 0022-3654 .- 1541-5740. ; 98:40, s. 10313-10321 Tidskriftsartikel (refereegranskat)abstract The photophysical properties of the optical DNA probe YOYO (homodimeric derivative of oxazole yellow) have been characterized in terms of the monomeric part, the YO chromophore. In aqueous solutions YO is virtually nonfluorescent but upon binding to DNA its fluorescence quantum yield is strongly increased. A similar enhancement of the fluorescence is observed for YO in the viscous solvent glycerol. The high fluorescence quantum yield of YO, when bound to DNA or in a viscous solution, is proposed to be a result of decreased rotational mobility around the internuclear bridge between the two aromatic ring systems. This hypothesis is based on similar values of the activation energies for the temperature-dependent nonradiative decay processes (E(A) = 53 kJ/mol) and viscous flow (E(A) = 63 kJ/mol), suggesting related rate-limiting mechanisms. A single electronic transition is found to be responsible for the intense visible absorption band. This conclusion is based on the observation of an essentially wavelength-independent reduced linear dichroism and similarly wavelength independent fluorescence anisotropy, and the fact that the emission spectrum is very nearly a mirror image of the absorption spectrum. The conclusion is further supported by quantum mechanical calculations (CNDO/S). By combination of measurements of fluorescence anisotropy of YO in glycerol and linear dichroism of YO in a stretched poly(vinyl alcohol) film, the transition moment of the strong visible absorption band was found to be nearly long axis polarized, in agreement with the CNDO/S calculations. The low-energy electronic transition and its polarization direction in the YO chromophore remain essentially unperturbed in the YOYO dye, suggesting that the results obtained for the excited state of the YO chromophore are applicable also to YOYO. One difference, though, is that in aqueous solutions the two YO chromophores of YOYO interact with each other, forming an internal dimer, resulting in a distorted absorption spectrum.
36.	Carlsson, Christina, 1968, et al. (författare) Screening for genetic mutations 1996 Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 380:6571, s. 207- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
37.	Carlsson, Hanna, et al. (författare) Subclinical Lyme borreliosis is common in south-eastern Sweden and may be distinguished from Lyme neuroborreliosis by sex, age and specific immune marker patterns 2018 Ingår i: Ticks and Tick-borne Diseases. - : ELSEVIER GMBH, URBAN & FISCHER VERLAG. - 1877-959X .- 1877-9603. ; 9:3, s. 742-748 Tidskriftsartikel (refereegranskat)abstract Background: Determinants of a subclinical course of Lyme borreliosis (LB) remain largely unknown. The aim of this study was to assess the extent, sex and age profiles of subclinical Borrelia seroconversion in a LB endemic area in Sweden and to map blood cellular Borrelia-specific immune marker patterns in individuals with a previous subclinical LB course compared with patients previously diagnosed with Lyme neuroborreliosis (LNB). Methods: A large group of 1113 healthy blood donors was screened for multiple IgG anti-Borrelia antibodies and asked to complete a health inquiry regarding previous LB. A group of subjects with anti-Borrelia-specific IgG antibodies but no previous history of LB (subclinical LB, n = 60) was identified together with 22 cases of previous LNB. Whole Borrelia spirochetes, strains B. afzelii ACA1 and B. garinii Ip90, were used for ex vivo whole blood stimulations, whereas outer surface protein enriched fractions of the same strains were used for stimulation of peripheral blood mononuclear cells (PBMCs). An extensive panel of immune markers was analysed in the supernatants after stimulation using multiplex bead arrays, and Borrelia-specific secretion was determined by subtracting the spontaneous secretion. Results: A total of 125/1113 blood donors reported previous clinical LB. In contrast, 66 donors denied previous LB but showed multiple IgG anti-Borrelia antibodies; these were defined as subclinical subjects, of whom 60 were available for further studies. The subclinical subjects consisted of significantly more men and had a younger age compared with the LNB patients (p amp;lt;= 0.01). Discriminant analysis revealed a distinct pattern of sex, age and PBMC B. garinii-specific levels of IL-10, IL-17A and CCL20 discriminating subclinical subjects from LNB patients. Conclusions: This study confirms that subclinical Borrelia seroconversion is common in south-eastern Sweden. The findings further suggest that male sex, younger age together with B. gariniii induced levels of IL-10, IL-17A and CCL20 may be associated with a subclinical course.
38.	Choque Olsson, Nora, et al. (författare) Social Skills Training for Children and Adolescents With Autism Spectrum Disorder : A Randomized Controlled Trial 2017 Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry. - : Elsevier BV. - 0890-8567 .- 1527-5418. ; 56:7, s. 585-592 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: Social skills group training (SSGT) for children and adolescents with autism spectrum disorder (ASD) is widely applied, but effectiveness in real-world practice has not yet been properly evaluated. This study sought to bridge this gap.METHOD: This 12-week pragmatic randomized controlled trial of SSGT compared to standard care alone was conducted at 13 child and adolescent psychiatry outpatient units in Sweden. Twelve sessions of manualized SSGT ("KONTAKT") were delivered by regular clinical staff. Participants (N = 296; 88 females and 208 males) were children (n = 172) and adolescents (n = 124) aged 8 to 17 years with ASD without intellectual disability. The primary outcome was the Social Responsiveness Scale rating by parents and blinded teachers. Secondary outcomes included parent- and teacher-rated adaptive behaviors, trainer-rated global functioning and clinical severity, and self-reported child and caregiver stress. Assessments were made at baseline, posttreatment, and 3-month follow-up. Moderator analyses were conducted for age and gender.RESULTS: Significant treatment effects on the primary outcome were limited to parent ratings for the adolescent subgroup (posttreatment: -8.3; 95% CI = -14.2 to -1.9; p = .012, effect size [ES] = 0.32; follow-up: -8.6; 95% CI = -15.4 to -1.8; p = .015, ES = 0.33) and females (posttreatment: -8.9; 95% CI = -16.2 to -1.6; p = .019, ES = 0.40). Secondary outcomes indicated moderate effects on adaptive functioning and clinical severity.CONCLUSION: SSGT for children and adolescents with ASD in regular mental health services is feasible and safe. However, the modest and inconsistent effects underscore the importance of continued efforts to improve SSGT beyond current standards.CLINICAL TRIAL REGISTRATION INFORMATION: Social Skills Group Training ("KONTAKT") for Children and Adolescent With High-functioning Autism Spectrum Disorders; https://clinicaltrials.gov/; NCT01854346.
39.	Claeson-Jonsson, Christina, 1967 (författare) Behavior of reinforced high strength concrete columns 1995 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)
40.	Claeson-Jonsson, Christina, 1967, et al. (författare) Slender concrete columns subjected to sustained and short-term eccentric loading 2000 Ingår i: ACI Structural Journal. - 0889-3241. ; 97:1, s. 45-52 Tidskriftsartikel (refereegranskat)abstract A test series examining the structural behavior of six slender reinforced concrete columns subjected to short-term and sustained loading is presented. The columns had cross sections 200 x 200 mm and were 4 m long. Concrete strengths used were 35 and 92 MPa with a load eccentricity of 20 mm. Key parameters such as concrete strength, concrete and steel strains, cracking, midheight deflection, and loading rate were studied. The high-strength (HSC) columns subjected to short-term loading displayed less ductility and more sudden failures than the normal strength concrete (NSC) columns. Furthermore, the tests conducted indicated that the structural behaviour of the HSC is favorable under sustained loading, i.e., the HSC column exhibited less tendency to creep and could sustain the axial load without much increase in deformation for a longer period of time. An analysis based on a simplified stability analysis, using a stress-strain relation for concrete that includes creep, aging, and the confining effect of the stirrups was carried out. The model was shown to simulate the load-deflection curves satisfactorily for all of the concrete columns.
41.	Claeson-Jonsson, Christina, 1967, et al. (författare) Specialist sprider kunskap och erfarenheter i projekt 2012 Ingår i: Husbyggaren. - 0018-7968. ; 12:7, s. 12-14 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
42.	Cunningham, Laura, et al. (författare) Preliminary Sampling Report from Stuor Guossásjavri, Northern Sweden 2008 Ingår i: European Climate of the Last Millennium, Millennium Milestone meeting 2, Cala Millor, Mallorca, 13th-15th March 2008. ; , s. 80-81 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
43.	Dellve, Lotta, 1965, et al. (författare) Myofeedback training and intensive muscular strength training to decrease pain and improve work ability among female workers on long-term sick leave with neck pain: a randomized controlled trial 2011 Ingår i: International archives of occupational and environmental health. - : Springer Science and Business Media LLC. - 1432-1246 .- 0340-0131. ; 84:3, s. 335-46 Tidskriftsartikel (refereegranskat)abstract Abstract The theoretical framework is that muscle tension in the neck is related to insufficient muscular rest and is a risk factor for chronic pain and reduced work ability. Promoting muscle strength and muscle rest may increase work ability and reduce neck pain. Objectives To test whether myofeedback training or intensive strength training leads to decreased pain and increased work ability in women on long-term sick leave. Methods This is a randomized controlled trial of two 1-month interventions with myofeedback or muscular strength training in the home environment. Female human service organization workers (n = 60) on long-term (>60 days) sick leave and with chronic neck pain were followed with self-reported and laboratory-observed data of health, pain, muscular activation, and work ability, at baseline, immediately after the intervention and 3 months after baseline. Results For both intervention groups, pain was lowered over time compared with the control group. Decreased pain and muscular activity was associated with increased self-rated work ability and with laboratory-observed work ability at 3-month follow-up. Decreased pain was also associated with increased self-rated work ability at 1-month follow-up. Muscular strength training was associated with increased self-rated work ability and mental health. Myofeedback was associated with increased observed work ability and self- rated vitality. Conclusions The two interventions showed positive results, suggesting that they could be developed for use in health care practice to address pain and work ability. The intensive muscular strength training program, which is both easy to conduct at home and easy to coach, was associated with increased work ability.
44.	Dierschke, Katrin, et al. (författare) Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates 2017 Ingår i: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 0340-0131 .- 1432-1246. ; 90:5, s. 451-463 Tidskriftsartikel (refereegranskat)abstract Welders are exposed to airborne particles from the welding environment and often develop symptoms work-related from the airways. A large fraction of the particles from welding are in the nano-size range. In this study we investigate if the welders' airways are affected by exposure to particles derived from gas metal arc welding in mild steel in levels corresponding to a normal welding day. In an exposure chamber, 11 welders with and 10 welders without work-related symptoms from the lower airways and 11 non-welders without symptoms, were exposed to welding fumes (1 mg/m(3)) and to filtered air, respectively, in a double-blind manner. Symptoms from eyes and upper and lower airways and lung function were registered. Blood and nasal lavage (NL) were sampled before, immediately after and the morning after exposure for analysis of markers of oxidative stress. Exhaled breath condensate (EBC) for analysis of leukotriene B4 (LT-B4) was sampled before, during and immediately after exposure. No adverse effects of welding exposure were found regarding symptoms and lung function. However, EBC LT-B4 decreased significantly in all participants after welding exposure compared to filtered air. NL IL-6 increased immediately after exposure in the two non-symptomatic groups and blood neutrophils tended to increase in the symptomatic welder group. The morning after, neutrophils and serum IL-8 had decreased in all three groups after welding exposure. Remarkably, the symptomatic welder group had a tenfold higher level of EBC LT-B4 compared to the two groups without symptoms. Despite no clinical adverse effects at welding, changes in inflammatory markers may indicate subclinical effects even at exposure below the present Swedish threshold limit (8 h TWA respirable dust).
45.	Disney, Oliver, 1985, et al. (författare) Total BIM As a Digital Disruption 2022 Ingår i: Association of Researchers in Construction Management, ARCOM 2022 - Proceedings of the 38th Annual Conference. - 9780995546363 ; 38, s. 32-41 Konferensbidrag (refereegranskat)abstract Digital technologies and information systems are challenging the construction industry. Existing literature focuses on different digital technologies in construction projects and the intricacies around technology improvement itself. However, there are limited discussions about how construction management (CM) organisations respond to disruptive change and pursue business model innovation. Drawing from emerging literature on digital disruption, we argue how the ‘Total BIM’ approach can disrupt the way value is created in a construction project. ‘Total BIM’ could be described as an approach where the design process and BIM are focused on production orientated design and BIM is used as the legally binding construction document. A construction management company in Sweden implemented the ‘Total BIM’ concept that embraced it to the fullest in the Celsius project This paper is based on data from in-depth interviews with construction management company practitioners from the Celsius project. It frames such improvement as a digital disruption which transforms the current traditional business models heavily based on the parallel processes of producing and maintaining 2D drawings for the construction site. Findings illustrate how the ‘Total BIM’ approach disturbs the existing roles, relations, and processes, creating cross organisational and systematic shifts.
46.	Egnell, Christina, et al. (författare) Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols 2020 Ingår i: European Journal of Haematology. - : WILEY. - 0902-4441 .- 1600-0609. ; 105:6, s. 797-807 Tidskriftsartikel (refereegranskat)abstract Objectives High body mass index (BMI) is associated with poorer survival in childhood acute lymphoblastic leukemia (ALL), but the actual impact on the risk of relapse still needs to be clarified. We evaluated the impact of BMI at diagnosis on the risk of relapse in children with ALL treated according to Nordic Society of Paediatric Haematology and Oncology (NOPHO) protocols. Method In a multicenter study, we collected data on BMI at diagnosis and outcome of 2558 children aged 2.0-17.9 years diagnosed between 1992 and 2016. Patients were divided into four groups according to International Obesity Task Force (IOTF) childhood BMI cut-offs: underweight, <17; healthy weight, 17-25; overweight, 25-30; and obese, >= 30 kg/m(2). Results In Cox multivariate regression analyses, an increased risk of relapse was observed in children aged 10-17.9 years with unhealthy BMI at diagnosis (underweight hazard ratio HR: 2.90 [95% confidence interval: 1.24-6.78],P = .01; overweight, HR: 1.95 [1.11-3.43],P = .02, and obese HR: 4.32 [95% 2.08-8.97],P < .001), compared to children with healthy weight. BMI had no impact on relapse in children under 10 years of age. Conclusion High BMI, and especially obesity at diagnosis, is an independent adverse prognostic factor for relapse in older children with ALL.
47.	Egnell, Christina, et al. (författare) Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia 2022 Ingår i: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 196:5, s. 1239-1247 Tidskriftsartikel (refereegranskat)abstract Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2 center dot 0-17 center dot 9 years with ALL treated with the Nordic Society of Pediatric Haematology and Oncology (NOPHO) ALL2008 non-high-risk protocol. Prospective treatment-related toxicities registered every three-month interval were used. Patients were classified according to sex- and age-adjusted international childhood cut-off values, corresponding to adult body mass index: underweight, <17 kg/m(2); healthy weight, 17 to <25 kg/m(2); overweight, 25 to <30 kg/m(2); and obese, >= 30 kg/m(2). Obese children had a higher incidence rate ratio (IRR) for severe toxic events {IRR: 1 center dot 55 [95% confidence interval (CI) 1 center dot 07-2 center dot 50]}, liver and kidney failures, bleeding, abdominal complication, suspected unexpected severe adverse reactions and hyperlipidaemia compared with healthy-weight children. Obese children aged >= 10 years had increased IRRs for asparaginase-related toxicities compared with healthy-weight older children: thromboses [IRR 2 center dot 87 (95% CI 1 center dot 00-8 center dot 21)] and anaphylactic reactions [IRR 7 center dot 95 (95% CI 2 center dot 15-29 center dot 37)] as well as higher risk for truncation of asparaginase [IRR 3 center dot 54 (95% CI 1 center dot 67-7 center dot 50)]. The high prevalence of toxicity and a higher risk of truncation of asparaginase may play a role in the poor prognosis of obese children aged >= 10 years with ALL.
48.	Ek, Kristine, 1975, et al. (författare) Multi-criteria decision analysis methods to support sustainable infrastructure construction 2019 Ingår i: IABSE Symposium, Guimaraes 2019: Towards a Resilient Built Environment Risk and Asset Management - Report. ; , s. 1084-1091 Konferensbidrag (refereegranskat)abstract The construction of infrastructure projects represents a large sustainability impact, both positive and negative. Increased positive and reduced negative impacts can be achieved through better design and planning of the construction. To make more sustainable choices, well‐defined predictive sustainability assessment methods are required. Multi‐criteria decision analysis (MCDA) is a well-suited method for predictive sustainability assessment. This paper evaluates two MCDA methods for sustainability assessment of infrastructure construction and exemplifies their application with two case studies. The aim of this paper is to discuss if the methods are suitable for identifying the most sustainable alternative during the procurement process of an infrastructure project. It is recommended that MCDA methods are further developed to comply with the recently published EN standard on sustainability assessment of civil engineering works.
49.	Ekström, Daniel P T, 1976, et al. (författare) Predicting project performance using pre-construction performance indicators - A case study evaluation 2019 Ingår i: 20th Congress of IABSE, New York City 2019: The Evolving Metropolis - Report. - 9783857481659 ; , s. 1438-1443 Konferensbidrag (refereegranskat)abstract Predicting the outcome of a construction project largely relies on estimated targets of time and cost. Still, hitting the targets does not mean that the project is a success on all performance levels. Here, a retrospective case study was undertaken on a construction project identified as a successful project by the partners involved. The purpose of the study was to validate conceptual design indicators of a high-performance construction project as reported in the literature, by answering the following research questions: "What characterizes the dialogue between the different disciplines; (2) What is the dialogue about; and (3) When in the process do questions arise?" Findings indicate that the interprofessional dialogue within the project team was well established. The paper introduces a discussion that the dialogue benefited from the collaborative project environment as well as the early design intent. Further, the study also suggests that the interprofessional dialogue supported a sound project team development.
50.	Evangelou, Evangelos, et al. (författare) Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 2011 Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 70:2, s. 349-355 Tidskriftsartikel (refereegranskat)abstract Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. Methods A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations. Replication of the top hits was attempted with data from 10 additional replication datasets. Results With a cumulative sample size of 6709 cases and 44 439 controls, one genome-wide significant locus was identified on chromosome 7q22 for knee OA (rs4730250, p = 9.2 x 10(-9)), thereby confirming its role as a susceptibility locus for OA. Conclusion The associated signal is located within a large (500 kb) linkage disequilibrium block that contains six genes: PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta), HPB1 (HMG-box transcription factor 1), COG5 (component of oligomeric golgi complex 5), GPR22 (G protein-coupled receptor 22), DUS4L (dihydrouridine synthase 4-like) and BCAP29 (B cell receptor-associated protein 29). Gene expression analyses of the (six) genes in primary cells derived from different joint tissues confirmed expression of all the genes in the joint environment.

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